@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : spr0975: (2018-01-02 )
MLKEIKRRNRMKNKRLIGIIAALAVLVAGSLIYSSMNKSEAQNNKDEKKITKIGVLQFVSHPSLDLIYKGIQDGLAEEGYKDDQVKIDFMNSEGDQSKVATMSKQLVANGNDLVVGIATPAAQGLASATKDLPVIMAAITDPIGANLVKDLKKPGGNVTGVSDHNPAQQQVELIKALTPNVKTIGALYSSSEDNSKTQVEEFKAYAEKAGLTVETFAVPSTNEIASTVTVMTSKVDAIWVPIDNTIASGFPTVVSSNQSSKKPIYPSATAMVEVGGLASVVIDQHDLGVATGKMIVQVLKGAKPADTPVNVFSIGKSVINKKIAQELGITIPESVLKEAGQVIE
Atome Classification :
(20 SA)
.........10........20........30........40........50........-60.........70.......-.80...-.....90..-......100.......110.......--120-.--.--....-.--.130.......140.......150.......160.......170......-----.-----180.--.......-190.-.--.--......200.......---210-.-.---...----------.---.--.--.--------220.......230-------..--.....240.......250.......--.--260.......270---.-----.---.---..--..----..280.......290.......300.......310.......320.......330.......340..
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
M
L
K
E
I
K
R
R
N
RMKN
K
R
L
I
G
I
I
A
A
L
A
V
L
V
A
G
S
L
I
Y
S
SMNKSEAQNN
K
D
E
K
K
I
T
K
I
G
V
L
Q
FV-S-HP
S
L
D
L
I
Y
K
G
I
Q
D
G
L
A
EE-GYKDD
Q
-
V
K
I
D
F
MNSE-G
D
Q
S
K
V
A
T
M
S
K
Q
L
VANG
N
D
L
V
V
G
IA
T
--
P
A
--
A
--
Q
--
G
L
A
S
-
A
--TKDL
P
V
I
M
A
A
ITDP
I
G
A
N
L
V
K
D
L
KKPGGNVTGVSDHN
P
A
Q
Q
Q
V
E
L
I
K
A
LT-----P-----N-
V
K
--
T
I
G
A
L
YS-S--S-E--D--NS
K
T
Q
V
E
E
F
K
A
Y
A
E
KA---G---
L
-
T
---
V
E
T
----------
F
---A--V--P--------S
T
N
E
I
A
S
T
V
T
V
M
T-------SK--V
D
A
I
W
V
PIDNTIASGFP-TVVSSNQ--S--SKKPIYPSA
T
A
-----
M
-----
V
---
E
---VG--
G
L
----
A
S
V
V
IDQHDL
G
V
A
T
G
K
M
I
V
Q
V
L
KGAKPADTP
V
N
V
F
S
I
G
K
S
V
I
N
K
K
I
A
Q
E
LGITI
P
E
S
V
L
K
EAGQVIE
3
HHSearch
99.32
99%
-92
- C3 -
-
3LFT
1
?
A:
[2-295]
-------------------------------------------------
N
A
K
I
G
V
L
Q
F
V
-
S
-
H
P
S
L
D
L
I
Y
K
G
I
Q
D
G
L
A
E
E
-
G
Y
K
D
D
Q
-
V
K
I
D
F
M
N
S
E
-
G
D
Q
S
K
V
A
T
M
S
K
Q
L
V
A
N
G
N
D
L
V
V
G
I
A
T
--
P
A
--
A
--
Q
--
G
L
A
S
-
A
--
T
K
D
L
P
V
I
M
A
A
I
T
D
P
I
G
A
N
L
V
K
D
L
K
K
P
G
G
N
V
T
G
V
S
D
H
N
P
A
Q
Q
Q
V
E
L
I
K
A
L
T
-----
P
-----
N
-
V
K
--
T
I
G
A
L
Y
S
-
S
--
S
-
E
--
D
--
N
S
K
T
Q
V
E
E
F
K
A
Y
A
E
K
A
---
G
---
L
-
T
---
V
E
T
----------
F
---
A
--
V
--
P
--------
S
T
N
E
I
A
S
T
V
T
V
M
T
-------
S
K
--
V
D
A
I
W
V
P
I
D
N
T
I
A
S
G
F
P
-
T
V
V
S
S
N
Q
--
S
--
S
K
K
P
I
Y
P
S
A
T
A
-----
M
-----
V
---
E
---
V
G
--
G
L
----
A
S
V
V
I
D
Q
H
D
L
G
V
A
T
G
K
M
I
V
Q
V
L
K
G
A
K
P
A
D
T
P
V
N
V
F
S
T
G
K
S
V
I
N
K
K
I
A
Q
E
L
G
I
T
I
P
E
S
V
L
K
E
A
G
Q
V
I
-
1
PsiBlast_PDB
98.50
97%
-93
- C3 -
-
3LFT
1
?
A:
[4-295]
---------------------------------------------------
K
I
G
V
L
Q
F
V
-
S
-
H
P
S
L
D
L
I
Y
K
G
I
Q
D
G
L
A
E
E
-
G
Y
K
D
D
Q
-
V
K
I
D
F
M
N
S
E
-
G
D
Q
S
K
V
A
T
M
S
K
Q
L
V
A
N
G
N
D
L
V
V
G
I
A
T
--
P
A
--
A
--
Q
--
G
L
A
S
-
A
--
T
K
D
L
P
V
I
M
A
A
I
T
D
P
I
G
A
N
L
V
K
D
L
K
K
P
G
G
N
V
T
G
V
S
D
H
N
P
A
Q
Q
Q
V
E
L
I
K
A
L
T
-----
P
-----
N
-
V
K
--
T
I
G
A
L
Y
S
-
S
--
S
-
E
--
D
--
N
S
K
T
Q
V
E
E
F
K
A
Y
A
E
K
A
---
G
---
L
-
T
---
V
E
T
----------
F
---
A
--
V
--
P
--------
S
T
N
E
I
A
S
T
V
T
V
M
T
-------
S
K
--
V
D
A
I
W
V
P
I
D
N
T
I
A
S
G
F
P
-
T
V
V
S
S
N
Q
--
S
--
S
K
K
P
I
Y
P
S
A
T
A
-----
M
-----
V
---
E
---
V
G
--
G
L
----
A
S
V
V
I
D
Q
H
D
L
G
V
A
T
G
K
M
I
V
Q
V
L
K
G
A
K
P
A
D
T
P
V
N
V
F
S
T
G
K
S
V
I
N
K
K
I
A
Q
E
L
G
I
T
I
P
E
S
V
L
K
E
A
G
Q
V
I
-
2
PsiBlast_PDB
66.80
41%
-16
- C3 -
-
3LKV
2
?
A:
[7-298]
------------------------------------------------
K
T
A
K
V
A
V
S
Q
I
V
-
E
-
H
P
A
L
D
A
T
R
Q
G
L
L
D
G
L
K
A
K
-
G
Y
E
E
G
K
N
L
E
F
D
Y
K
T
A
Q
-
G
N
P
A
I
A
V
Q
I
A
R
Q
F
V
G
E
N
P
D
V
L
V
G
I
A
T
--
P
T
--
A
--
Q
--
A
L
V
S
-
A
--
T
K
T
I
P
I
V
F
T
A
V
T
D
P
V
G
A
K
L
V
K
Q
L
E
Q
P
G
K
N
V
T
G
L
S
D
L
S
P
V
E
Q
H
V
E
L
I
K
E
I
L
-----
P
-----
N
-
V
K
--
S
I
G
V
V
Y
N
-
P
--
G
-
E
--
A
--
N
A
V
S
L
M
E
L
L
K
L
S
A
A
K
H
---
G
---
I
K
L
---
V
E
A
----------
T
---
A
--
L
--
K
--------
S
A
D
-
V
Q
S
A
T
Q
A
I
A
-------
E
K
--
S
D
V
I
Y
A
L
I
D
N
T
V
A
S
A
I
E
G
M
I
V
A
A
N
Q
-----
A
K
T
P
V
F
G
A
A
T
S
-----
Y
-----
V
---
E
---
R
G
--
A
I
----
A
S
L
G
F
D
Y
Y
Q
I
G
V
Q
T
A
D
Y
V
A
A
I
L
E
G
K
E
P
G
S
L
D
V
Q
V
A
K
G
S
D
L
V
I
N
K
T
A
A
E
Q
L
G
I
T
I
P
E
A
V
L
A
R
A
-----
23
HHSearch
45.97
12%
-45
- C3 -
-
3K9C
1
?
B:
[9-261]
----------------------------------------------
Q
A
S
S
R
L
L
G
V
V
F
E
L
-
Q
-
Q
P
F
H
G
D
L
V
E
Q
I
Y
A
A
A
T
R
R
-
G
Y
---
D
---
V
M
L
S
A
V
A
-
P
S
-
R
A
E
K
V
A
V
Q
A
L
M
R
E
R
C
E
A
A
I
L
L
G
T
--
R
F
--
D
--
T
--
D
E
L
G
-
A
L
-
A
D
R
V
P
A
L
V
V
A
R
A
S
G
L
P
----------
G
V
G
A
V
R
G
D
D
V
A
G
I
T
L
A
V
D
H
L
T
E
L
------------
G
-
H
R
--
N
I
A
H
I
D
G
-
A
--
D
-
A
--
P
--
G
G
A
D
R
R
A
G
F
L
A
A
M
D
R
H
---
G
---
L
-
S
---
A
S
A
----------
T
V
--
V
--
T
G
G
T
--------
T
E
T
E
G
A
E
G
M
H
T
L
L
E
MP----
T
P
--
P
T
A
V
V
A
F
N
D
R
C
A
T
G
V
L
D
-
L
L
V
R
S
G
R
--
D
VP
A
D
I
S
V
V
G
Y
D
D
S
-----
R
-----
L
ARI
P
---
H
V
--
Q
M
----
T
T
I
S
Q
D
A
T
H
M
A
E
A
A
V
D
G
A
L
A
Q
I
S
G
D
K
A
V
---------------------------------------
22
HHSearch
45.93
12%
-50
- C3 -
-
3K9C
1
?
A:
[13-261]
--------------------------------------------------
R
L
L
G
V
V
F
E
L
-
Q
-
Q
P
F
H
G
D
L
V
E
Q
I
Y
A
A
A
T
R
R
-
G
Y
---
D
---
V
M
L
S
A
V
A
-
P
S
-
R
A
E
K
V
A
V
Q
A
L
M
R
E
R
C
E
A
A
I
L
L
G
T
--
R
F
--
D
--
T
--
D
E
L
G
-
A
L
-
A
D
R
V
P
A
L
V
V
A
R
A
S
G
L
P
----------
G
V
G
A
V
R
G
D
D
V
A
G
I
T
L
A
V
D
H
L
T
E
L
------------
G
-
H
R
--
N
I
A
H
I
D
G
-
A
--
D
-
A
--
P
--
G
G
A
D
R
R
A
G
F
L
A
A
M
D
R
H
---
G
---
L
-
S
---
A
S
A
----------
T
V
--
V
--
T
G
G
T
--------
T
E
T
E
G
A
E
G
M
H
T
L
L
E
MP----
T
P
--
P
T
A
V
V
A
F
N
D
R
C
A
T
G
V
L
D
-
L
L
V
R
S
G
R
--
D
VP
A
D
I
S
V
V
G
Y
D
D
S
-----
R
-----
L
ARI
P
---
H
V
--
Q
M
----
T
T
I
S
Q
D
A
T
H
M
A
E
A
A
V
D
G
A
L
A
Q
I
S
G
D
K
A
V
---------------------------------------
13
HHSearch
45.32
17%
5
- C3 -
-
3H5O
-
?
B:
[63-318]
--------------------------------------------------
R
T
V
L
V
L
I
P
S
L
A
-
N
T
V
F
L
E
T
L
T
G
I
E
T
V
L
D
A
A
-
G
Y
------
Q
M
L
I
G
N
S
H
-
Y
D
A
G
Q
E
L
Q
L
L
R
A
Y
L
Q
H
R
P
D
G
V
L
I
T
G
L
--
S
H
--
A
--
E
--
P
F
E
R
-
I
LS
Q
H
A
L
P
V
V
Y
M
M
D
L
A
D
D
G
-----------
R
C
C
V
G
F
S
Q
E
D
A
G
A
A
I
T
R
H
L
L
S
R
------------
G
-
K
R
--
R
I
G
F
L
G
A
-
Q
--
L
-
D
--
E
--
R
V
M
K
R
L
D
G
Y
R
A
A
L
D
A
A
---
D
---
C
-
R
---
D
A
G
----------
L
EWL
D
PQ
P
--
S
--------
S
M
Q
M
G
A
D
M
L
D
R
A
L
AER----
P
D
--
C
D
A
L
F
C
C
N
D
D
L
A
I
G
A
L
A
-
R
S
Q
Q
L
G
I
--
A
VP
E
R
L
A
I
A
G
F
N
D
L
-----
Q
-----
P
---
A
AWC
T
P
--
P
L
----
T
T
V
A
T
P
R
R
D
I
G
V
H
A
A
K
A
L
L
Q
L
I
D
G
E
E
P
A
S
R
R
------------------------------------
14
HHSearch
43.72
10%
-46
- C3 -
-
2QU7
-
?
A:
[7-262]
------------------------------------------------
R
S
N
I
I
A
F
I
V
P
D
-
Q
-
N
P
F
F
T
E
V
L
T
E
I
S
H
E
C
Q
K
H
-
H
L
------
H
V
A
V
A
S
S
E
-
E
N
E
D
K
Q
Q
D
L
I
E
T
F
V
S
Q
N
V
S
A
I
I
L
V
P
V
--
K
S
--
K
--
F
--
Q
M
K
R
-
E
--
W
L
K
I
P
I
M
T
L
D
R
E
L
E
S
T
----------
S
L
P
S
I
T
V
D
N
E
E
A
A
Y
I
A
T
K
R
V
L
E
S
------------
T
-
C
K
--
E
V
G
L
L
L
A
-
N
--
P
-
N
I-
S
--
T
T
I
G
R
K
N
G
Y
N
K
A
I
S
E
F
---
D
---
L
-
N
---
V
N
P
----------
S
LI-
H
--
Y
--
S
DQQLG
T
N
A
Q
I
Y
S
G
Y
E
A
T
K
T
L
L
S
------
K
G
--
I
K
G
I
V
A
T
N
H
L
L
L
L
G
A
L
Q
-
A
I
K
E
S
E
K
EI
K
--
K
D
V
I
I
V
G
F
D
D
S
-----
Y
-----
W
N
E
I
Y
---
T
P
--
K
L
----
T
V
I
S
Q
P
V
K
E
M
G
Q
V
A
A
K
M
I
Y
K
L
I
K
G
K
D
V
----------------------------------------
29
HHSearch
42.61
18%
1
* C3 *
-
1RZR
2
CCPA_BACME
C:
[57-314]
----------------------------------------------
S
K
K
T
T
T
V
G
V
I
I
P
D
I
S
-
N
I
F
Y
A
E
L
A
R
G
I
E
D
I
A
T
M
Y
-
K
Y
------
N
I
I
L
S
N
S
D
-
Q
N
Q
D
K
E
L
H
L
L
N
N
M
L
G
K
Q
V
D
G
I
I
F
M
S
G
--
N
V
--
T
--
E
--
E
H
V
E
-
E
LK
K
S
P
V
P
V
V
L
A
A
S
I
E
S
T
N
----------
Q
I
P
S
V
T
I
D
Y
E
Q
A
A
F
D
A
V
Q
S
L
I
D
S
------------
G
-
H
K
--
N
I
A
F
V
S
G
-
T
--
L
-
E
EP
I
--
N
H
A
K
K
V
K
G
Y
K
R
A
L
T
E
S
---
G
---
L
-
P
---
V
R
D
----------
S
---
Y
IV
E
--
G
DY------
T
Y
D
S
G
I
E
A
V
E
K
L
L
EED----
E
K
--
P
T
A
I
F
V
G
T
D
E
M
A
L
G
V
I
H
-
G
A
Q
D
R
G
L
NV
P
--
N
D
L
E
I
I
G
F
D
N
T
-----
R
-----
L
---
S
TMV
R
P
--
Q
L
----
T
S
V
V
Q
P
M
Y
D
I
G
A
V
A
M
R
L
L
T
K
Y
M
N
K
E
T
V
----------------------------------------
25
HHSearch
40.76
12%
-11
- C3 -
-
4XXH
1
TRER_ECOLI
A:
[2-243]
-------------------------------------------------
D
K
V
V
A
I
I
V
T
R
L
D
-
S
L
S
E
N
L
A
V
Q
T
M
L
P
A
F
Y
E
Q
-
G
Y
---
D
---
P
I
M
M
E
S
Q
-
F
S
P
Q
L
V
A
E
H
L
G
V
L
K
R
R
N
I
D
G
V
V
L
F
G
F
--
T
G
--
I
--
T
E-
E
M
L
A
----
H
W
Q
S
S
L
V
L
L
A
R
D
A
K
G
------------
F
A
S
V
C
Y
D
D
E
G
A
I
K
I
L
M
Q
R
L
Y
D
Q
------------
G
-
H
R
--
N
I
S
Y
L
G
V
-
P
--
H
-
S
--
D
VT
T
G
K
R
R
H
E
A
Y
L
A
F
C
K
A
H
---
K
---
L
-
H
---
P
V
A
----------
A
---
L
--
P
G-
L
--------
A
M
K
Q
G
Y
E
N
V
A
K
V
I
T------
P
E
--
T
T
A
L
L
C
A
T
D
T
L
A
L
G
A
S
K
-
Y
L
Q
E
Q
R
I
-----
D
T
L
Q
L
A
S
V
G
N
T
-----
P
-----
L
---
M
K
F
L
H
P
--
E
I
----
V
T
V
D
P
G
Y
A
E
A
G
R
Q
A
A
C
Q
L
I
A
Q
V
T
G
R
S
-----------------------------------------
27
HHSearch
40.74
15%
14
- C3 -
-
2O20
-
?
B:
[60-314]
----------------------------------------------
S
K
R
T
T
T
V
G
V
I
L
P
T
I
T
-
S
T
Y
F
A
A
I
T
R
G
V
D
D
I
A
S
M
Y
-
K
Y
------
N
M
I
L
A
N
S
D
-
N
D
V
E
K
E
E
K
V
L
E
T
F
L
S
K
Q
V
D
G
I
V
Y
M
G
S
--
S
L
--
D
--
E
--
K
I
R
T
-
S
L
K
N
S
R
T
P
V
V
L
V
G
T
I
D
G
D
K
----------
E
I
P
S
V
N
I
D
Y
H
L
A
A
Y
Q
S
T
K
K
L
I
D
S
------------
G
-
N
K
--
K
I
A
Y
I
M
G
-
S
--
L
K
D
--
V
--
E
N
T
E
R
M
V
G
Y
Q
E
A
L
L
E
A
---
N
---
I
-
E
---
F
D
E
----------
N
LV-
F
EG
N
--
Y
--------
S
Y
E
Q
G
K
A
L
A
E
R
L
L
E
------
R
G
--
A
T
S
A
V
V
S
H
D
T
V
A
V
G
L
L
S
-
A
M
M
D
K
G
V
--
K
VP
E
D
F
E
I
I
S
G
A
N
S
-----
P
-----
I
---
T
Q
Y
T
Y
P
--
T
L
----
T
S
V
N
Q
P
L
Y
D
L
G
A
V
A
M
R
L
L
T
K
L
M
L
K
E
D
V
----------------------------------------
28
HHSearch
40.72
15%
10
- C3 -
-
2O20
-
?
C:
[63-314]
-------------------------------------------------
T
T
T
V
G
V
I
L
P
T
I
T
-
S
T
Y
F
A
A
I
T
R
G
V
D
D
I
A
S
M
Y
-
K
Y
------
N
M
I
L
A
N
S
D
-
N
D
V
E
K
E
E
K
V
L
E
T
F
L
S
K
Q
V
D
G
I
V
Y
M
G
S
--
S
L
--
D
--
E
--
K
I
R
T
-
S
L
K
N
S
R
T
P
V
V
L
V
G
T
I
D
G
D
K
----------
E
I
P
S
V
N
I
D
Y
H
L
A
A
Y
Q
S
T
K
K
L
I
D
S
------------
G
-
N
K
--
K
I
A
Y
I
M
G
-
S
--
L
K
D
--
V
--
E
N
T
E
R
M
V
G
Y
Q
E
A
L
L
E
A
---
N
---
I
-
E
---
F
D
E
----------
N
LV-
F
EG
N
--
Y
--------
S
Y
E
Q
G
K
A
L
A
E
R
L
L
E
------
R
G
--
A
T
S
A
V
V
S
H
D
T
V
A
V
G
L
L
S
-
A
M
M
D
K
G
V
--
K
VP
E
D
F
E
I
I
S
G
A
N
S
-----
P
-----
I
---
T
Q
Y
T
Y
P
--
T
L
----
T
S
V
N
Q
P
L
Y
D
L
G
A
V
A
M
R
L
L
T
K
L
M
L
K
E
D
V
----------------------------------------
5
HHSearch
40.57
15%
29
- C3 -
-
4YO7
1
?
A:
[40-304]
--------------------------------------------
T
G
D
S
G
Q
K
V
I
G
V
S
I
S
N
-
L
-
D
E
F
L
T
Y
M
Q
D
A
M
K
E
E
A
A
N
Y
P
D
F
------
E
F
I
F
S
D
A
Q
-
N
D
S
T
Q
Q
M
A
Q
V
E
N
F
I
S
R
N
V
D
A
I
I
V
N
P
V
--
D
T
--
T
S
A
V
--
D
I
V
N
-
M
V
N
D
A
G
I
P
I
I
I
A
N
R
T
F
D
G
V
D
--------
Q
A
T
A
F
V
G
S
E
S
I
Q
S
G
L
L
Q
M
E
E
V
A
K
L
L
-----
N
-----
N
-
E
G
--
N
I
A
I
M
D
G
-
E
--
L
-
G
H-
E
--
A
Q
I
M
R
T
E
G
N
K
Q
I
I
E
E
H
D--
G
---
L
-
E
---
V
V
L
----------
Q
---
G
--
T
AK
F
--------
D
R
S
E
G
M
R
L
M
E
N
W
L
N
S
G----
T
E
--
I
D
A
V
V
A
N
N
D
E
M
A
L
G
A
I
L
-
A
L
E
A
V
G
K
--
L
--
D
D
V
I
V
A
G
I
D
A
T
-----
P
A
A
L
E
A
M
---
K
---
E
G
--
K
L
D---
V
T
V
F
Q
D
A
K
G
Q
G
A
T
S
V
K
V
A
V
Q
A
A
N
G
E
D
V
----------------------------------------
11
HHSearch
40.12
13%
2
- C3 -
-
3JY6
2
?
D:
[8-256]
--------------------------------------------------
K
L
I
A
V
I
V
A
N
I
D
-
D
Y
F
S
T
E
L
F
K
G
I
S
S
I
L
E
S
R
-
G
Y
---
I
---
G
V
L
F
D
A
N
-
A
D
I
E
R
E
K
T
L
L
R
A
I
G
S
R
G
F
D
G
L
I
L
Q
S
F
--
S
N
--
P
--
Q
--
T
V
Q
E
-
I
L
-
H
Q
Q
M
P
V
V
S
V
D
R
E
M
D
A
C
----------
P
W
P
Q
V
V
T
D
N
F
E
A
A
K
A
A
T
T
A
F
R
Q
Q
------------
G
-
Y
Q
--
H
V
V
V
L
T
S
-
E
--
L
-
E
LS
R
--
T
R
Q
E
R
Y
R
G
I
L
A
A
A
Q
D
V
---
D
---
V
-
L
---
E
V
S
----------
E
---
S
--
S
--
Y
---------
H
S
E
V
H
Q
R
L
T
Q
L
I
T
Q
N----
D
Q
--
K
T
V
A
F
A
L
K
E
R
W
L
L
E
F
F
P
-
N
L
I
I
S
G
L
ID
N
--
Q
T
V
T
A
T
G
F
A
D
T
-----
D
-----
F
---
I
RRM
E
P
--
K
L
----
T
L
I
T
Q
N
P
F
L
M
G
A
S
S
A
E
I
M
L
R
Q
L
A
G
E
K
V
----------------------------------------
7
HHSearch
38.66
15%
15
- C3 -
-
4YS6
1
?
A:
[37-314]
--------------------------------------------------
K
L
V
G
V
A
M
P
T
-
K
D
L
Q
R
W
N
Q
D
G
S
N
M
E
K
Q
L
K
D
A
-
G
Y
------
E
V
D
L
Q
Y
A
S
-
N
D
V
Q
T
Q
V
S
Q
I
E
N
M
I
S
N
G
C
K
L
L
V
I
A
S
I
--
E
G
--
D
SL
G
--
T
V
L
A
-
Q
A
K
K
K
G
I
S
V
I
A
Y
D
R
L
I
M
N
S
D
--------
A
V
S
Y
Y
A
T
F
D
N
Y
M
V
G
T
K
Q
G
E
Y
I
K
E
K
L
-----
N
LETAK
G
-
P
F
--
N
L
E
I
F
T
G
-
D
P-
G
-
D
--
N
--
N
A
R
F
F
Y
G
G
A
M
D
V
L
K
P
Y
---
V
D
G
G
V
-
L
---
V
V
K
SGSVAFEKVA
T
---
A
--
G
--
W
--------
S
T
E
T
A
Q
N
R
M
D
A
I
I
A
S
YYADG
T
K
--
L
D
A
V
L
C
S
N
D
S
T
A
L
G
V
T
N
-
A
L
T
A
S
Y
K
--
G
--
E
W
P
I
V
T
G
Q
D
C
D
I
A
N
V
K
N
-----
M
---
L
---
D
G
K-
Q
S
----
M
S
I
F
K
D
T
R
T
L
A
S
Q
V
V
K
M
V
D
A
I
M
K
G
G
E
A
----------------------------------------
8
HHSearch
38.56
13%
26
- C3 -
-
4YV7
1
?
A:
[39-298]
------------------------------------------------
G
A
L
K
I
G
F
S
Q
A
T
-
Q
Q
S
P
F
Y
V
A
L
T
D
A
A
K
A
E
A
Q
A
Q
-
G
D
------
E
L
F
Y
A
D
A
N
-
G
D
I
T
K
Q
N
N
D
V
Q
D
L
I
T
R
G
I
N
V
L
V
I
N
P
V
--
D
P
--
K
GV
T
--
P
S
L
A
-
A
A
E
A
A
G
I
K
V
V
T
V
D
R
P
V
E
S
G
----------
A
A
S
F
V
G
R
D
N
K
A
M
G
E
L
V
G
K
A
A
V
D
T
L
-----
G
-----
P
D
G
G
--
K
I
I
E
I
Q
G
D
A
--
G
-
G
--
A
--
V
A
R
D
R
R
D
G
F
Q
A
A
V
S
G
R
P--
N
---
I
-
T
---
I
V
E
----------
G
---
P
--
Y
CD
Y
--------
I
R
S
K
A
V
T
A
M
Q
D
L
L
Q
A
H
----
P
D
--
L
K
G
V
Y
A
Q
N
D
D
M
A
L
G
A
M
Q
-
V
L
A
E
N
N
R
-----
T
D
V
K
V
F
G
V
D
G
L
-----
M
E
A
V
R
A
I
---
A
---
D
G
DQ
Y
V
----
A
T
A
L
N
D
P
D
A
E
G
R
L
A
I
Q
T
A
A
K
V
A
R
G
E
S
V
----------------------------------------
10
HHSearch
36.88
12%
27
- C3 -
-
4KZK
1
?
A:
[37-310]
--------------------------------------------------
V
K
I
G
F
V
V
K
Q
P
D
-
D
P
W
F
Q
D
E
W
R
F
A
E
Q
A
A
K
D
K
-
H
F
------
T
L
V
K
I
A
A
--
P
S
G
E
K
V
S
T
A
L
D
S
L
A
A
Q
K
A
Q
G
V
I
I
C
A
P
--
D
V
KL
G
--
P
--
G
I
A
A
-
K
A
K
R
Y
G
M
K
L
M
S
V
D
D
Q
L
V
D
G
R
G
A
--
P
--
L
A
D
V
P
H
M
G
I
S
A
Y
R
I
G
R
Q
V
G
D
A
I
A
A
E
A
-----
K
R
R
---
G
-
W
N
PA
E
V
G
V
L
R
L
-
A
YD
Q
-
L
--
P
--
T
A
R
E
R
T
T
G
A
V
D
A
L
K
A
A
---
G
---
F
-
A
AAN
V
V
D
----------
A
---
P
--
E
MT
A
--------
D
T
E
G
A
F
N
A
A
N
I
A
F
T
K
H
----
R
N
FR
H
W
V
A
F
G
S
N
D
D
T
T
V
G
A
V
R
-
A
G
E
G
R
G
I
--
G
T-
D
D
M
I
A
V
G
I
N
G
S
-----
Q
V
A
L
N
E
F
---
A
---
K
P
--
K
P
TGFF
G
S
I
L
L
N
P
R
L
H
G
Y
D
T
S
V
N
M
Y
D
W
I
T
Q
N
R
-----------------------------------------
9
HHSearch
36.83
10%
41
- C3 -
-
4YLE
1
?
A:
[30-301]
-----------------------------------------------
A
G
K
P
K
V
A
L
V
M
K
S
L
A
-
N
E
F
F
L
T
M
E
N
G
A
K
E
Y
Q
K
H
N
-
A
S
Q
F
-
D
-
L
I
T
N
G
I
K
D
E
-
T
D
T
A
N
Q
I
R
I
V
E
Q
M
I
V
S
K
V
D
A
I
V
L
A
P
A
--
D
S
--
K
AL
V
--
P
V
V
K
-
K
A
V
D
A
G
I
I
V
V
N
I
D
N
R
L
D
P
D
V
L
---
K
S
K
N
L
N
V
P
F
V
G
P
D
N
R
K
G
A
R
K
V
G
D
Y
L
A
K
K
L
-----
K
-----
A
-
G
D
--
Q
V
G
I
V
E
G
-
V
S-
T
-
T
--
T
--
N
A
Q
Q
R
T
A
G
F
Q
D
A
M
K
A
G
---
G
---
M
-
K
---
V
V
S
----------
V
---
Q
--
S
GE
W
--------
E
I
D
K
G
N
A
V
A
S
A
M
L
N
E
Y
----
P
N
--
L
K
A
L
L
C
G
N
D
N
M
A
I
G
A
V
S
-
A
V
R
A
A
G
K
--
Q
--
G
K
V
Y
V
V
G
Y
D
N
I
-----
N
AI
K
P
M
L
---
K
---
D
G
R-
V
L
----
A
T
A
D
Q
Y
A
A
K
Q
A
V
F
G
I
D
T
A
L
K
A
I
A
E
H
R
-----------------------------------------
6
HHSearch
33.77
11%
34
- C3 -
-
4WZZ
3
?
A:
[51-319]
----------------------------------------------
Y
A
T
T
A
T
Y
A
I
I
V
K
S
A
G
-
N
P
Y
N
Q
K
E
S
E
G
Y
K
Q
V
I
E
A
N
-
G
G
------
K
C
V
I
Q
E
P
K
S
A
T
A
E
D
Q
I
T
C
I
N
N
A
I
S
Q
G
V
D
C
I
A
I
A
A
N
DT
D
A
--
L
--
E
--
P
A
L
T
-
E
A
K
N
Q
G
I
H
V
L
S
L
D
S
A
T
N
A
N
S
--------
R
K
V
F
V
N
Q
A
G
T
T
Q
I
A
Q
A
L
M
D
A
I
L
D
I
S
-----
G
-----
G
-
S
G
--
D
W
A
V
L
S
A
-
A
S-
T
-
A
--
T
--
N
Q
N
A
W
I
D
G
M
K
T
V
M
Q
D
S
KYS
K
---
L
-
N
---
L
I
G
----------
V
---
Y
--
Y
GD
D
--------
E
Y
Q
A
S
C
D
Q
T
E
A
I
L
A
A
D----
P
N
--
I
K
V
I
C
A
P
T
T
V
G
I
M
A
A
A
K
-
V
L
Q
D
K
G
L
--
S
--
G
K
V
K
L
T
G
L
G
L
P
-----
S
EMADY
I
---
G
---
D
D
--
D
Q
HSCP
Y
M
F
L
W
N
P
I
Q
L
G
N
L
A
A
Y
A
S
I
S
L
V
N
G
T
I
T
----------------------------------------
19
HHSearch
33.45
13%
45
- C3 -
-
4RXT
1
?
A:
[2-269]
-----------------------------------------------
M
A
E
V
T
I
P
I
I
V
K
D
-
T
T
S
F
Y
W
Q
I
V
L
A
G
A
R
K
A
G
K
D
L
-
G
V
---
K
-
V
P
E
L
G
A
Q
A
E
-
T
D
V
N
G
Q
I
S
I
L
E
N
A
V
A
G
K
P
A
A
I
V
I
S
P
T
--
E
F
--
K
--
A
L
G
K
P
V
D
-
E
A
-
A
K
S
V
P
I
I
G
I
D
S
G
A
D
S
K
A
---------
F
K
S
F
L
T
T
D
N
T
Q
G
G
R
I
A
A
D
G
L
A
A
A
I
K
A
M
TG
K
-----
E
-
E
G
--
D
V
V
I
I
T
N
-
T
--
P
G
A
--
G
--
S
L
E
Q
R
R
T
G
F
L
D
Q
V
K
T
K
YP-
G
---
L
-
K
---
V
V
A
----------
D
---
K
Y
A
D
--
G
--------
Q
A
T
T
G
L
N
I
M
T
D
L
I
T
A
N
----
P
K
--
I
V
G
V
F
A
S
N
L
I
M
A
Q
G
V
G
Q
-
A
I
A
E
N
K
L
--
S
--
D
K
V
K
V
I
G
F
D
S
D
-----
D
K
T
L
G
F
L
---
K
---
S
G
--
A
I
A---
G
L
V
V
Q
D
P
Y
R
M
G
Y
D
G
I
K
T
A
L
A
V
S
K
G
E
K
V
----------------------------------------
26
HHSearch
31.85
12%
41
- C3 -
-
4WUT
1
?
A:
[24-287]
--------------------------------------------------
G
E
I
A
V
I
V
K
T
V
N
-
S
T
F
W
Q
N
V
Q
K
G
A
D
A
A
I
G
K
Q
-
K
A
H
--
T
-
I
T
F
Q
G
P
A
A
E
-
S
A
I
A
D
Q
V
N
M
V
E
N
A
V
N
R
K
V
D
A
I
L
L
A
P
S
--
D
P
--
D
--
A
L
V
P
A
V
K
K
A
W
-
E
A
R
I
P
V
V
I
I
D
S
M
L
S
K
D
A
E
------
K
Y
Y
Q
A
F
L
A
T
D
N
K
A
A
G
E
L
A
A
K
A
M
I
Q
K
V
-----
G
-----
T
-
E
G
--
K
I
A
V
M
S
Y
-
V
--
A
G
A
--
G
--
S
E
I
G
R
V
G
G
F
T
D
Y
I
K
A
N
---
S
K--
L
-
Q
---
I
V
G
----------
P
---
Y
YS
Q
--
S
--------
Q
M
A
T
A
L
N
Q
T
T
D
V
L
A
A
N
----
A
D
--
L
K
G
I
F
G
A
N
E
P
T
A
I
G
M
G
R
-
A
I
K
Q
A
G
K
--
A
--
G
K
L
V
A
I
G
F
D
G
N
-----
Q
D
L
Q
E
F
V
---
K
---
D
G
--
T
L
E---
A
T
V
V
Q
G
S
Y
Q
M
G
E
K
G
V
D
T
L
L
K
L
L
S
K
E
K
V
----------------------------------------