@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : spr0989: (2018-01-02 )
MRKIVINGGLPLQGEITISGAKNSVVALIPAIILADDVVTLDCVPDISDVASLVEIMELMGATVKRYDDVLEIDPRGVQNIPMPYGKINSLRASYYFYGSLLGRFGEATVGLPGGCDLGPRPIDLHLKAFEAMGATASYEGDNMKLSAKDTGLHGASIYMDTVSVGATINTMIAAVKANGRTIIENAAREPEIIDVATLLNNMGAHIRGAGTNIIIIDGVERLHGTRHQVIPDRIEAGTYISLAAAVGKGIRINNVLYEHLEGFVAKLEEMGVRMTVSEDSIFVEEQSNLKAINIKTAPYPGFATDLQQPLTPLLLRANGRGTIVDTIYEKRVNHVFELAKMDADISTTNGHILYTGGRDLRGASVKATDLRAGAALVIAGLMAEGKTEITNIEFILRGYSDIIEKLRNLGADIRLVED
Atome Classification :
(22 SA)
.........10........20........30.-.....-..40........50........60.....-...70........80........90.....-...100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.-..-......230.......240.......250........260........270.......280.....-.-.290........300.......310.......320--.......330.......340.......350.-......360.......-.370.......380.......390.......400.......410.......
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
M
R
K
I
V
INGGL
P
L
Q
G
E
I
T
I
SGAKN
S
V
V
A
L
I
P
A
I
-
I
LAD
D
-
V
V
T
L
DCVP
D
I
S
D
V
A
S
L
V
E
I
M
E
L
M
G
A
T
V
K
R
-YD
D
V
L
EIDPRGVQNIPMPYG
K
I
N
S
L
R
A
S
Y
Y
-
F
Y
G
S
L
L
GRFGEATVGLPGGCDLGPR
P
I
D
L
H
L
K
A
F
E
AMGATASYEGD
N
M
K
L
SAKDTGLHG
A
S
I
Y
M
D
T
V
SVGA
T
I
N
T
M
I
A
A
VKAN
G
R
T
I
I
E
NAAREP
E
I
I
D
V
A
T
L
L
N
NMGA
H
I
RGAG
T
N
I
I
I
ID
G
V
--
E
-
R
L-HGTRHQVI
P
D
RIEAG
T
Y
I
S
L
A
A
A
VGKG-I
R
I
N
N
V
L
Y
E
H
-
L
E
G
F
V
A
K
L
E
EMG
V
R
M
T
VSED
S
I
F
V
EEQ-S-N
L
-
K
A
I
N
I
KTAPYPG
F
A
T
D
L
QQP
L
T
P
L
L
L
RANGRG--
T
I
V
D
T
I
Y
E
K
R
V
N
H
V
F
E
L
A
KMDADISTTN
G
H
I
-
L
Y
TGGRD-LRG
A
S
V
K
A-
T
D
LRA
G
A
A
L
V
I
A
G
L
MAEGKTEIT
N
I
E
F
I
L
R
G
Y
S
D
I
I
E
K
L
R
NLGA
D
I
R
LVED
2
PsiBlast_PDB
97.64
99%
-121
- C8 -
-
3ZH4
1
MURA1_STRPI
A:
[1-418]
M
R
K
I
V
I
N
G
G
L
P
L
Q
G
E
I
T
I
S
G
A
K
N
S
V
V
A
L
I
P
A
I
-
I
L
A
D
D
-
V
V
T
L
D
C
V
P
D
I
S
D
V
A
S
L
V
E
I
M
E
L
M
G
A
T
V
K
R
-
Y
D
D
V
L
E
I
D
P
R
G
V
Q
N
I
P
M
P
---
I
N
S
L
R
A
S
Y
Y
-
F
Y
G
S
L
L
G
R
F
G
E
A
T
V
G
L
----
D
L
G
P
R
P
I
D
L
H
L
K
A
F
E
A
M
G
A
T
A
S
Y
E
G
D
N
M
K
L
S
A
K
D
T
G
L
H
G
A
S
I
Y
M
D
T
V
S
V
G
A
T
I
N
T
M
I
A
A
V
K
A
N
G
R
T
I
I
E
N
A
A
R
E
P
E
I
I
D
V
A
T
L
L
N
N
M
G
A
H
I
R
G
A
G
T
N
I
I
I
I
D
G
V
--
E
-
R
L
-
H
G
T
R
H
Q
V
I
P
D
R
I
E
A
G
T
Y
I
S
L
A
A
A
V
G
K
G
-
I
R
I
N
N
V
L
Y
E
H
-
L
E
G
F
I
A
K
L
E
E
M
G
V
R
M
T
V
S
E
D
S
I
F
V
E
E
Q
-
S
-
N
L
-
K
A
I
N
I
K
T
A
P
Y
P
G
F
A
T
D
L
Q
Q
P
L
T
P
L
L
L
R
A
N
G
R
G
--
T
I
V
D
T
I
Y
E
K
R
V
N
H
V
F
E
L
A
K
M
D
A
D
I
S
T
T
N
G
H
I
-
L
Y
T
G
G
R
D
-
L
R
G
T
S
V
K
A
-
T
D
L
R
A
G
A
A
L
V
I
A
G
L
M
A
E
G
K
T
E
I
T
N
I
E
F
I
L
R
G
Y
S
D
I
I
E
K
L
R
N
L
G
A
D
I
R
L
V
E
-
46
HHSearch
86.18
97%
-35
- C8 -
-
3ZH4
1
MURA1_STRPI
A:
[1-418]
M
R
K
I
V
I
N
G
G
L
P
L
Q
G
E
I
T
I
S
G
A
K
N
S
V
V
A
L
I
P
A
I
-
I
L
A
D
D
-
V
V
T
L
D
C
V
P
D
I
S
D
V
A
S
L
V
E
I
M
E
L
M
G
A
T
V
K
R
-
Y
D
D
V
L
E
I
D
P
R
G
V
Q
N
I
P
M
P
----
I
N
S
L
R
A
S
Y
Y
F
Y
G
S
L
L
G
R
F
G
E
A
T
V
G
L
----
D
L
G
P
R
P
I
D
L
H
L
K
A
F
E
A
M
G
A
T
A
S
Y
E
G
D
N
M
K
L
S
A
K
D
T
G
L
H
G
A
S
I
Y
M
D
T
V
S
V
G
A
T
I
N
T
M
I
A
A
V
K
A
N
G
R
T
I
I
E
N
A
A
R
E
P
E
I
I
D
V
A
T
L
L
N
N
M
G
A
H
I
R
G
A
G
T
N
I
I
I
I
D
G
V
--
E
-
R
L
-
H
G
T
R
H
Q
V
I
P
D
R
I
E
A
G
T
Y
I
S
L
A
A
A
V
G
K
G
-
I
R
I
N
N
V
L
Y
E
H
-
L
E
G
F
I
A
K
L
E
E
M
G
V
R
M
T
V
S
E
D
S
I
F
V
E
E
Q
-
S
-
N
L
-
K
A
I
N
I
K
T
A
P
Y
P
G
F
A
T
D
L
Q
Q
P
L
T
P
L
L
L
R
A
N
G
R
G
--
T
I
V
D
T
I
Y
E
K
R
V
N
H
V
F
E
L
A
K
M
D
A
D
I
S
T
T
N
G
H
I
-
L
Y
T
G
G
R
D
-
L
R
G
T
S
V
-
K
A
T
D
L
R
A
G
A
A
L
V
I
A
G
L
M
A
E
G
K
T
E
I
T
N
I
E
F
I
L
R
G
Y
S
D
I
I
E
K
L
R
N
L
G
A
D
I
R
L
V
E
-
10
PsiBlast_PDB
75.80
44%
-84
- C8 -
-
1NAW
-
MURA_ENTCC
A:
[1-417]
M
D
K
F
R
V
Q
G
P
T
R
L
Q
G
E
V
T
I
S
G
A
K
N
A
A
L
P
I
L
F
A
A
-
L
L
A
E
E
-
P
V
E
I
Q
N
V
P
K
L
K
D
I
D
T
T
M
K
L
L
T
Q
L
G
T
K
V
E
R
-
N
G
S
V
W
-
I
D
A
S
N
V
N
N
F
S
A
P
Y
D
L
V
K
T
M
R
A
S
I
W
-
A
L
G
P
L
V
A
R
F
G
Q
G
Q
V
S
L
P
G
G
C
A
I
G
A
R
P
V
D
L
H
I
F
G
L
E
K
L
G
A
E
I
K
L
E
E
G
Y
V
K
A
S
V
N
G
R
-
L
K
G
A
H
I
V
M
D
K
V
S
V
G
A
T
V
T
I
M
S
A
A
T
L
A
E
G
T
T
I
I
E
N
A
A
R
E
P
E
I
V
D
T
A
N
F
L
V
A
L
G
A
K
I
S
G
Q
G
T
D
R
I
T
I
E
G
V
--
E
-
R
L
-
G
G
G
V
Y
R
V
L
P
D
R
I
E
T
G
T
F
L
V
A
A
A
I
S
G
G
K
-
I
V
C
R
N
A
Q
P
D
T
-
L
D
A
V
L
A
K
L
R
E
A
G
A
D
I
E
T
G
E
D
W
I
S
L
D
M
H
-
G
-
K
R
P
K
A
V
T
V
R
T
A
P
H
P
A
F
P
T
D
M
Q
A
Q
F
T
L
L
N
L
V
A
E
G
T
G
--
V
I
T
E
T
I
F
E
N
R
F
M
H
V
P
E
L
I
R
M
G
A
H
A
E
I
E
S
N
T
V
-
I
C
H
G
V
E
K
-
L
S
G
A
Q
V
M
A
-
T
D
L
R
A
S
A
S
L
V
L
A
G
C
I
A
E
G
T
T
V
V
D
R
I
Y
H
I
D
R
G
Y
E
R
I
E
D
K
L
R
A
L
G
A
N
I
E
R
V
K
-
9
PsiBlast_PDB
75.33
44%
-81
- C8 -
-
3SPB
-
MURA_ENTCC
A:
[1-417]
M
D
K
F
R
V
Q
G
P
T
R
L
Q
G
E
V
T
I
S
G
A
K
N
A
A
L
P
I
L
F
A
A
-
L
L
A
E
E
-
P
V
E
I
Q
N
V
P
K
L
K
D
I
D
T
T
M
K
L
L
T
Q
L
G
T
K
V
E
R
--
G
S
V
W
-
I
D
A
S
N
V
N
N
F
S
A
P
Y
D
L
V
K
T
M
R
A
S
I
W
-
A
L
G
P
L
V
A
R
F
G
Q
G
Q
V
S
L
P
G
G
C
A
I
G
A
R
P
V
D
L
H
I
F
G
L
E
K
L
G
A
E
I
K
L
E
E
G
Y
V
K
A
S
V
N
G
R
-
L
K
G
A
H
I
V
M
D
K
V
S
V
G
A
T
V
T
I
M
S
A
A
T
L
A
E
G
T
T
I
I
E
N
A
A
R
E
P
E
I
V
D
T
A
N
F
L
V
A
L
G
A
K
I
S
G
Q
G
T
D
R
I
T
I
E
G
V
--
E
-
R
L
-
G
G
G
V
Y
R
V
L
P
D
R
I
E
T
G
T
F
L
V
A
A
A
I
S
G
G
K
-
I
V
C
R
N
A
Q
P
D
T
-
L
D
A
V
L
A
K
L
R
E
A
G
A
D
I
E
T
G
E
D
W
I
S
L
D
M
H
-
G
-
K
R
P
K
A
V
T
V
R
T
A
P
H
P
A
F
P
T
D
M
Q
A
Q
F
T
L
L
N
L
V
A
E
G
T
G
--
V
I
T
E
T
I
F
E
N
R
F
M
H
V
P
E
L
I
R
M
G
A
H
A
E
I
E
S
N
T
V
-
I
C
H
G
V
E
K
-
L
S
G
A
Q
V
M
A
-
T
D
L
R
A
S
A
S
L
V
L
A
G
C
I
A
E
G
T
T
V
V
D
R
I
Y
H
I
D
R
G
Y
E
R
I
E
D
K
L
R
A
L
G
A
N
I
E
R
V
K
-
16
PsiBlast_PDB
74.60
37%
-94
- C8 -
-
2YVW
1
MURA_AQUAE
A:
[13-424]
---
F
V
I
R
G
G
K
P
L
T
G
K
V
K
I
S
G
A
K
N
A
A
L
P
I
M
F
A
T
-
I
L
T
E
E
-
P
C
T
I
T
N
V
P
D
L
L
D
V
R
N
T
L
L
L
L
R
E
L
G
A
E
L
E
F
-
L
N
N
T
V
F
I
N
P
-
S
I
N
S
F
I
T
N
Q
E
I
I
R
R
M
R
A
S
V
L
-
S
L
G
P
L
L
G
R
F
G
R
A
V
V
G
L
P
G
G
C
S
I
G
A
R
P
I
D
Q
H
L
K
F
F
K
E
A
G
A
D
V
E
V
R
E
G
Y
V
Y
V
N
L
K
E
K
--
R
R
V
H
F
K
F
D
L
V
T
V
T
G
T
E
N
A
L
L
Y
L
A
S
V
P
E
E
S
I
L
E
N
I
A
L
E
P
E
V
M
D
L
I
E
V
L
K
K
M
G
A
H
V
K
V
E
G
R
S
A
Y
V
-
K
G
S
--
E
-
N
L
-
K
G
F
T
H
S
V
I
P
D
R
I
E
A
G
T
F
M
V
G
A
V
L
T
D
G
E
-
I
L
L
E
N
A
R
I
N
H
-
L
R
A
V
V
E
K
L
K
L
I
G
G
E
V
V
E
E
N
G
N
L
R
V
F
R
K
-
E
-
S
L
-
R
A
C
D
I
E
T
Q
V
Y
P
G
F
P
T
D
M
Q
A
Q
F
M
A
L
L
S
V
A
K
G
K
S
--
R
I
K
E
N
I
F
E
H
R
F
H
H
A
Q
E
L
N
R
L
G
A
N
I
-
T
V
R
G
N
T
-
A
Y
V
E
G
V
E
R
L
Y
G
S
E
V
Y
S
-
T
D
L
R
A
S
A
S
L
V
L
A
G
L
V
A
Q
G
E
T
V
V
R
D
V
Y
H
L
D
R
G
Y
E
K
L
E
E
K
L
K
K
L
G
A
D
I
E
R
V
S
E
24
PsiBlast_CBE
73.25
46%
-75
- C8 -
-
4R7U
2
MURA_VIBCH
D:
[9-421]
----
V
I
G
S
T
Q
P
L
Q
G
E
V
T
I
S
G
A
K
N
A
A
L
P
I
L
F
A
S
-
I
L
A
E
E
-
P
V
E
V
A
N
V
P
H
L
R
D
I
D
T
T
M
E
L
L
E
R
L
G
A
K
V
E
R
-
N
G
S
V
-
H
V
D
A
G
P
I
N
Q
Y
C
A
P
Y
D
L
V
K
T
M
R
A
S
I
W
-
A
L
G
P
L
V
A
R
F
G
Q
G
Q
V
S
L
P
G
G
C
A
I
G
A
R
P
V
D
L
H
I
H
G
L
E
Q
L
G
A
T
I
T
L
E
D
G
Y
V
K
A
H
V
-
D
G
R
L
Q
G
A
H
I
V
M
D
K
V
S
V
G
A
T
I
T
I
M
C
A
A
T
L
A
E
G
T
T
V
L
D
N
A
A
R
E
P
E
I
V
D
T
A
M
F
L
N
K
L
G
A
K
I
S
G
A
G
T
D
S
I
T
I
E
G
V
--
E
-
R
L
-
G
G
G
K
H
A
V
V
P
D
R
I
E
T
G
T
F
L
-
V
A
A
A
V
S
R
G
-
K
I
V
C
R
N
T
H
A
H
L
L
E
A
V
L
A
K
L
E
E
A
G
A
E
I
E
C
G
E
D
W
I
S
L
D
M
T
-
G
R
E
L
-
K
A
V
T
V
R
T
A
P
H
P
G
F
P
T
D
M
Q
A
Q
F
T
L
L
N
M
M
A
K
G
G
G
--
V
I
T
E
T
I
F
E
N
R
F
M
H
V
P
E
L
K
R
M
G
A
K
-
A
E
I
E
G
N
T
-
V
I
C
G
D
V
D
R
L
S
G
A
Q
V
M
A
-
T
D
L
R
A
S
A
S
L
V
I
A
G
C
I
A
K
G
E
T
I
V
D
R
I
Y
H
I
D
R
G
Y
E
R
I
E
D
K
L
S
A
L
G
A
N
I
E
R
F
R
-
5
PsiBlast_PDB
73.10
45%
-64
- C8 -
-
1UAE
2
MURA_ECOLI
A:
[1-417]
M
D
K
F
R
V
Q
G
P
T
K
L
Q
G
E
V
T
I
S
G
A
K
N
A
A
L
P
I
L
F
A
A
-
L
L
A
E
E
-
P
V
E
I
Q
N
V
P
K
L
K
D
V
D
T
S
M
K
L
L
S
Q
L
G
A
K
V
E
R
-
N
G
S
V
-
H
I
D
A
R
D
V
N
V
F
C
A
P
Y
D
L
V
K
T
M
R
A
S
I
W
-
A
L
G
P
L
V
A
R
F
G
Q
G
Q
V
S
L
P
G
G
C
T
I
G
A
R
P
V
D
L
H
I
S
G
L
E
Q
L
G
A
T
I
K
L
E
E
G
Y
V
K
A
S
V
-
D
G
R
L
K
G
A
H
I
V
M
D
K
V
S
V
G
A
T
V
T
I
M
C
A
A
T
L
A
E
G
T
T
I
I
E
N
A
A
R
E
P
E
I
V
D
T
A
N
F
L
I
T
L
G
A
K
I
S
G
Q
G
T
D
R
I
V
I
E
G
V
--
E
-
R
L
-
G
G
G
V
Y
R
V
L
P
D
R
I
E
T
G
T
F
L
-
V
A
A
A
I
S
R
G
K
I
I
C
R
N
A
Q
P
D
T
-
L
D
A
V
L
A
K
L
R
D
A
G
A
D
I
E
V
G
E
D
W
I
S
L
D
M
H
-
G
-
K
R
P
K
A
V
N
V
R
T
A
P
H
P
A
F
P
T
D
M
Q
A
Q
F
T
L
L
N
L
V
A
E
G
T
G
--
F
I
T
E
T
V
F
E
N
R
F
M
H
V
P
E
L
S
R
M
G
A
H
A
E
I
E
S
N
T
V
-
I
C
H
G
V
E
K
-
L
S
G
A
Q
V
M
A
-
T
D
L
R
A
S
A
S
L
V
L
A
G
C
I
A
E
G
T
T
V
V
D
R
I
Y
H
I
D
R
G
Y
E
R
I
E
D
K
L
R
A
L
G
A
N
I
E
R
V
K
-
12
PsiBlast_PDB
73.01
42%
-85
- C8 -
-
5U4H
3
?
A:
[4-420]
M
D
K
F
L
I
T
G
G
V
K
L
E
G
E
V
R
I
S
G
A
K
N
A
A
L
P
L
L
A
A
M
-
I
L
A
D
S
-
P
I
T
L
T
N
V
P
N
L
K
D
V
N
T
L
V
K
L
I
G
G
L
G
V
T
I
S
Y
-
E
N
D
T
V
K
A
D
T
S
T
L
D
N
Q
F
A
P
Y
E
L
V
K
T
M
R
A
S
I
L
-
V
L
G
P
L
L
A
R
Y
G
N
A
K
V
S
L
P
G
G
C
A
I
G
S
R
P
V
D
Q
H
L
K
A
L
E
A
L
G
A
H
I
E
V
E
N
G
Y
V
H
A
T
V
-
D
G
R
L
K
G
G
E
V
V
F
D
M
V
T
V
G
G
T
E
N
I
L
M
A
A
A
L
A
D
G
V
T
T
I
R
N
A
A
R
E
P
E
I
T
D
L
A
Q
M
L
I
K
M
G
A
K
I
E
G
L
D
T
D
T
L
V
V
T
G
V
--
E
-
S
L
-
H
G
C
E
Y
A
V
V
A
D
R
I
E
T
G
S
Y
L
A
A
A
A
I
T
G
G
R
-
V
K
T
T
H
T
D
P
S
L
-
L
E
A
V
L
D
K
F
E
E
M
G
A
E
V
T
R
G
D
D
W
I
E
L
D
M
L
-
G
-
K
R
P
K
A
V
S
F
R
T
L
P
H
P
E
F
P
T
D
M
Q
A
Q
I
--
M
A
V
N
A
I
G
R
G
F
A
T
I
S
E
T
I
F
E
N
R
F
M
H
V
P
E
L
S
R
M
G
A
N
I
Q
V
E
G
H
D
A
-
V
V
T
G
V
E
K
-
L
Q
A
A
P
V
M
A
-
T
D
L
R
A
S
F
S
L
V
L
A
A
L
V
A
E
G
D
T
L
I
D
R
I
Y
H
I
D
R
G
Y
E
H
V
E
E
K
L
Q
G
L
G
A
K
I
K
R
V
--
26
PsiBlast_CBE
72.87
46%
-74
- C8 -
-
4R7U
2
MURA_VIBCH
B:
[9-421]
----
V
I
G
S
T
Q
P
L
Q
G
E
V
T
I
S
G
A
K
N
A
A
L
P
I
L
F
A
S
-
I
L
A
E
E
-
P
V
E
V
A
N
V
P
H
L
R
D
I
D
T
T
M
E
L
L
E
R
L
G
A
K
V
E
R
-
N
G
S
V
-
H
V
D
A
G
P
I
N
Q
Y
C
A
P
Y
D
L
V
K
T
M
R
A
S
I
W
-
A
L
G
P
L
V
A
R
F
G
Q
G
Q
V
S
L
P
G
G
C
A
I
G
A
R
P
V
D
L
H
I
H
G
L
E
Q
L
G
A
T
I
T
L
E
D
G
Y
V
K
A
H
V
-
D
G
R
L
Q
G
A
H
I
V
M
D
K
V
S
V
G
A
T
I
T
I
M
C
A
A
T
L
A
E
G
T
T
V
L
D
N
A
A
R
E
P
E
I
V
D
T
A
M
F
L
N
K
L
G
A
K
I
S
G
A
G
T
D
S
I
T
I
E
G
V
--
E
-
R
L
-
G
G
G
K
H
A
V
V
P
D
R
I
E
T
G
T
F
L
-
V
A
A
A
V
S
R
G
-
K
I
V
C
R
N
T
H
A
H
L
L
E
A
V
L
A
K
L
E
E
A
G
A
E
I
E
C
G
E
D
W
I
S
L
D
M
T
-
G
R
E
L
-
K
A
V
T
V
R
T
A
P
H
P
G
F
P
T
D
M
Q
A
Q
F
T
L
L
N
M
M
A
K
G
G
G
--
V
I
T
E
T
I
F
E
N
R
F
M
H
V
P
E
L
K
R
M
G
A
K
-
A
E
I
E
G
N
T
-
V
I
C
G
D
V
D
R
L
S
G
A
Q
V
M
A
-
T
D
L
R
A
S
A
S
L
V
I
A
G
C
I
A
K
G
E
T
I
V
D
R
I
Y
H
I
D
R
G
Y
E
R
I
E
D
K
L
S
A
L
G
A
N
I
E
R
F
R
-
4
PsiBlast_PDB
72.84
46%
-73
- C8 -
-
4R7U
3
MURA_VIBCH
A:
[9-421]
----
V
I
G
S
T
Q
P
L
Q
G
E
V
T
I
S
G
A
K
N
A
A
L
P
I
L
F
A
S
-
I
L
A
E
E
-
P
V
E
V
A
N
V
P
H
L
R
D
I
D
T
T
M
E
L
L
E
R
L
G
A
K
V
E
R
-
N
G
S
V
-
H
V
D
A
G
P
I
N
Q
Y
C
A
P
Y
D
L
V
K
T
M
R
A
S
I
W
-
A
L
G
P
L
V
A
R
F
G
Q
G
Q
V
S
L
P
G
G
C
A
I
G
A
R
P
V
D
L
H
I
H
G
L
E
Q
L
G
A
T
I
T
L
E
D
G
Y
V
K
A
H
V
-
D
G
R
L
Q
G
A
H
I
V
M
D
K
V
S
V
G
A
T
I
T
I
M
C
A
A
T
L
A
E
G
T
T
V
L
D
N
A
A
R
E
P
E
I
V
D
T
A
M
F
L
N
K
L
G
A
K
I
S
G
A
G
T
D
S
I
T
I
E
G
V
--
E
-
R
L
-
G
G
G
K
H
A
V
V
P
D
R
I
E
T
G
T
F
L
-
V
A
A
A
V
S
R
G
-
K
I
V
C
R
N
T
H
A
H
L
L
E
A
V
L
A
K
L
E
E
A
G
A
E
I
E
C
G
E
D
W
I
S
L
D
M
T
-
G
R
E
L
-
K
A
V
T
V
R
T
A
P
H
P
G
F
P
T
D
M
Q
A
Q
F
T
L
L
N
M
M
A
K
G
G
G
--
V
I
T
E
T
I
F
E
N
R
F
M
H
V
P
E
L
K
R
M
G
A
K
-
A
E
I
E
G
N
T
-
V
I
C
G
D
V
D
R
L
S
G
A
Q
V
M
A
-
T
D
L
R
A
S
A
S
L
V
I
A
G
C
I
A
K
G
E
T
I
V
D
R
I
Y
H
I
D
R
G
Y
E
R
I
E
D
K
L
S
A
L
G
A
N
I
E
R
F
R
-
32
PsiBlast_CBE
72.64
42%
-85
- C8 -
-
5U4H
3
?
B:
[4-420]
M
D
K
F
L
I
T
G
G
V
K
L
E
G
E
V
R
I
S
G
A
K
N
A
A
L
P
L
L
A
A
M
-
I
L
A
D
S
-
P
I
T
L
T
N
V
P
N
L
K
D
V
N
T
L
V
K
L
I
G
G
L
G
V
T
I
S
Y
-
E
N
D
T
V
K
A
D
T
S
T
L
D
N
Q
F
A
P
Y
E
L
V
K
T
M
R
A
S
I
L
-
V
L
G
P
L
L
A
R
Y
G
N
A
K
V
S
L
P
G
G
C
A
I
G
S
R
P
V
D
Q
H
L
K
A
L
E
A
L
G
A
H
I
E
V
E
N
G
Y
V
H
A
T
V
-
D
G
R
L
K
G
G
E
V
V
F
D
M
V
T
V
G
G
T
E
N
I
L
M
A
A
A
L
A
D
G
V
T
T
I
R
N
A
A
R
E
P
E
I
T
D
L
A
Q
M
L
I
K
M
G
A
K
I
E
G
L
D
T
D
T
L
V
V
T
G
V
--
E
-
S
L
-
H
G
C
E
Y
A
V
V
A
D
R
I
E
T
G
S
Y
L
A
A
A
A
I
T
G
G
R
-
V
K
T
T
H
T
D
P
S
L
-
L
E
A
V
L
D
K
F
E
E
M
G
A
E
V
T
R
G
D
D
W
I
E
L
D
M
L
-
G
-
K
R
P
K
A
V
S
F
R
T
L
P
H
P
E
F
P
T
D
M
Q
A
Q
I
--
M
A
V
N
A
I
G
R
G
FA
T
I
S
E
T
I
F
E
N
R
F
M
H
V
P
E
L
S
R
M
G
A
N
I
Q
V
E
G
H
D
A
-
V
V
T
G
V
E
K
-
L
Q
A
A
P
V
M
A
-
T
D
L
R
A
S
F
S
L
V
L
A
A
L
V
A
E
G
D
T
L
I
D
R
I
Y
H
I
D
R
G
Y
E
H
V
E
E
K
L
Q
G
L
G
A
K
I
K
R
V
--
25
PsiBlast_CBE
72.36
46%
-73
- C8 -
-
4R7U
2
MURA_VIBCH
C:
[9-422]
----
V
I
G
S
T
Q
P
L
Q
G
E
V
T
I
S
G
A
K
N
A
A
L
P
I
L
F
A
S
-
I
L
A
E
E
-
P
V
E
V
A
N
V
P
H
L
R
D
I
D
T
T
M
E
L
L
E
R
L
G
A
K
V
E
R
-
N
G
S
V
-
H
V
D
A
G
P
I
N
Q
Y
C
A
P
Y
D
L
V
K
T
M
R
A
S
I
W
-
A
L
G
P
L
V
A
R
F
G
Q
G
Q
V
S
L
P
G
G
C
A
I
G
A
R
P
V
D
L
H
I
H
G
L
E
Q
L
G
A
T
I
T
L
E
D
G
Y
V
K
A
H
V
-
D
G
R
L
Q
G
A
H
I
V
M
D
K
V
S
V
G
A
T
I
T
I
M
C
A
A
T
L
A
E
G
T
T
V
L
D
N
A
A
R
E
P
E
I
V
D
T
A
M
F
L
N
K
L
G
A
K
I
S
G
A
G
T
D
S
I
T
I
E
G
V
--
E
-
R
L
-
G
G
G
K
H
A
V
V
P
D
R
I
E
T
G
T
F
L
-
V
A
A
A
V
S
R
G
-
K
I
V
C
R
N
T
H
A
H
L
L
E
A
V
L
A
K
L
E
E
A
G
A
E
I
E
C
G
E
D
W
I
S
L
D
M
T
-
G
R
E
L
-
K
A
V
T
V
R
T
A
P
H
P
G
F
P
T
D
M
Q
A
Q
F
T
L
L
N
M
M
A
K
G
G
G
--
V
I
T
E
T
I
F
E
N
R
F
M
H
V
P
E
L
K
R
M
G
A
K
-
A
E
I
E
G
N
T
-
V
I
C
G
D
V
D
R
L
S
G
A
Q
V
M
A
-
T
D
L
R
A
S
A
S
L
V
I
A
G
C
I
A
K
G
E
T
I
V
D
R
I
Y
H
I
D
R
G
Y
E
R
I
E
D
K
L
S
A
L
G
A
N
I
E
R
F
R
D
65
HHSearch
72.12
42%
-83
* C8 *
-
5U4H
3
?
B:
[4-420]
M
D
K
F
L
I
T
G
G
V
K
L
E
G
E
V
R
I
S
G
A
K
N
A
A
L
P
L
L
A
A
M
-
I
L
A
D
S
-
P
I
T
L
T
N
V
P
N
L
K
D
V
N
T
L
V
K
L
I
G
G
L
G
V
T
I
S
Y
-
E
N
D
T
V
K
A
D
T
S
T
L
D
N
Q
F
A
P
Y
E
L
V
K
T
M
R
A
S
I
L
-
V
L
G
P
L
L
A
R
Y
G
N
A
K
V
S
L
P
G
G
C
A
I
G
S
R
P
V
D
Q
H
L
K
A
L
E
A
L
G
A
H
I
E
V
E
N
G
Y
V
H
A
T
V
D
-
G
R
L
K
G
G
E
V
V
F
D
M
V
T
V
G
G
T
E
N
I
L
M
A
A
A
L
A
D
G
V
T
T
I
R
N
A
A
R
E
P
E
I
T
D
L
A
Q
M
L
I
K
M
G
A
K
I
E
G
L
D
T
D
T
L
V
V
T
G
V
--
E
-
S
L
-
H
G
C
E
Y
A
V
V
A
D
R
I
E
T
G
S
Y
L
A
A
A
A
I
T
G
G
R
-
V
K
T
T
H
T
D
P
S
L
-
L
E
A
V
L
D
K
F
E
E
M
G
A
E
V
T
R
G
D
D
W
I
E
L
D
M
L
G
K
-
R
P
-
K
A
V
S
F
R
T
L
P
H
P
E
F
P
T
D
M
Q
A
Q
I
M
A
V
N
A
I
G
R
G
F
A
--
T
I
S
E
T
I
F
E
N
R
F
M
H
V
P
E
L
S
R
M
G
A
N
I
Q
V
E
G
H
D
A
-
V
V
T
G
V
E
K
-
L
Q
A
A
-
P
V
M
A
T
D
L
R
A
S
F
S
L
V
L
A
A
L
V
A
E
G
D
T
L
I
D
R
I
Y
H
I
D
R
G
Y
E
H
V
E
E
K
L
Q
G
L
G
A
K
I
K
R
V
--
8
PsiBlast_PDB
71.63
45%
-62
- C8 -
-
1A2N
-
MURA_ECOLI
A:
[1-417]
M
D
K
F
R
V
Q
G
P
T
K
L
Q
G
E
V
T
I
S
G
A
K
N
A
A
L
P
I
L
F
A
A
-
L
L
A
E
E
-
P
V
E
I
Q
N
V
P
K
L
K
D
V
D
T
S
M
K
L
L
S
Q
L
G
A
K
V
E
R
-
N
G
S
V
-
H
I
D
A
R
D
V
N
V
F
C
A
P
Y
D
L
V
K
T
M
R
A
S
I
W
-
A
L
G
P
L
V
A
R
F
G
Q
G
Q
V
S
L
P
G
G
A
T
I
G
A
R
P
V
D
L
H
I
S
G
L
E
Q
L
G
A
T
I
K
L
E
E
G
Y
V
K
A
S
V
-
D
G
R
L
K
G
A
H
I
V
M
D
K
V
S
V
G
A
T
V
T
I
M
C
A
A
T
L
A
E
G
T
T
I
I
E
N
A
A
R
E
P
E
I
V
D
T
A
N
F
L
I
T
L
G
A
K
I
S
G
Q
G
T
D
R
I
V
I
E
G
V
--
E
-
R
L
-
G
G
G
V
Y
R
V
L
P
D
R
I
E
T
G
T
F
L
-
V
A
A
A
I
S
R
G
K
I
I
C
R
N
A
Q
P
D
T
-
L
D
A
V
L
A
K
L
R
D
A
G
A
D
I
E
V
G
E
D
W
I
S
L
D
M
H
-
G
-
K
R
P
K
A
V
N
V
R
T
A
P
H
P
A
F
P
T
D
M
Q
A
Q
F
T
L
L
N
L
V
A
E
G
T
G
--
F
I
T
E
T
V
F
E
N
R
F
M
H
V
P
E
L
S
R
M
G
A
H
A
E
I
E
S
N
T
V
-
I
C
H
G
V
E
K
-
L
S
G
A
Q
V
M
A
-
T
D
L
R
A
S
A
S
L
V
L
A
G
C
I
A
E
G
T
T
V
V
D
R
I
Y
H
I
D
R
G
Y
E
R
I
E
D
K
L
R
A
L
G
A
N
I
E
R
V
K
-
1
PsiBlast_PDB
71.45
99%
-
- C8 -
-
3ZH3
-
MURA1_STRP2
A:
[1-419]
M
R
K
I
V
I
N
G
G
L
P
L
Q
G
E
I
T
I
S
G
A
K
N
S
V
V
A
L
I
P
A
I
-
I
L
A
D
D
-
V
V
T
L
D
C
V
P
D
I
S
D
V
A
S
L
V
E
I
M
E
L
M
G
A
T
V
K
R
-
Y
D
D
V
L
E
I
D
P
R
G
V
Q
N
I
P
M
P
Y
G
K
I
N
S
L
R
A
S
Y
Y
-
F
Y
G
S
L
L
G
R
F
G
E
A
T
V
G
L
P
-------
R
P
I
D
L
H
L
K
A
F
E
A
M
G
A
T
A
S
Y
E
G
D
N
M
K
L
S
A
K
D
T
G
L
H
G
A
S
I
Y
M
D
T
V
S
V
G
A
T
I
N
T
M
I
A
A
V
K
A
N
G
R
T
I
I
E
N
A
A
R
E
P
E
I
I
D
V
A
T
L
L
N
N
M
G
A
H
I
R
G
A
G
T
N
I
I
I
I
D
G
V
--
E
-
R
L
-
H
G
T
R
H
Q
V
I
P
D
R
I
E
A
G
T
Y
I
S
L
A
A
A
V
G
K
G
-
I
R
I
N
N
V
L
Y
E
H
-
L
E
G
F
I
A
K
L
E
E
M
G
V
R
M
T
V
S
E
D
S
I
F
V
E
E
Q
-
S
-
N
L
-
K
A
I
N
I
K
T
A
P
Y
P
G
F
A
T
D
L
Q
Q
P
L
T
P
L
L
L
R
A
N
G
R
G
--
T
I
V
D
T
I
Y
E
K
R
V
N
H
V
F
E
L
A
K
M
D
A
D
I
S
T
T
N
G
H
I
-
L
Y
T
G
G
R
D
-
L
R
G
A
S
V
K
A
-
T
D
L
R
A
G
A
A
L
V
I
A
G
L
M
A
E
G
K
T
E
I
T
N
I
E
F
I
L
R
G
Y
S
D
I
I
E
K
L
R
N
L
G
A
D
I
R
L
V
E
D
15
PsiBlast_PDB
71.28
39%
-59
- C8 -
-
5UJS
-
MURA_CAMJE
A:
[25-442]
M
T
Y
L
E
I
E
G
T
N
H
L
S
G
N
V
T
I
S
G
A
K
N
A
A
L
P
L
I
V
S
S
-
I
L
A
K
N
-
E
V
K
I
N
N
V
P
N
V
A
D
I
K
T
L
I
S
L
L
E
N
L
G
A
K
V
N
F
-
Q
N
N
S
A
L
L
N
T
N
T
L
N
Q
T
I
A
K
Y
D
I
V
R
K
M
R
A
S
I
L
-
T
L
G
P
L
L
A
R
F
G
H
C
E
V
S
L
P
G
G
C
A
I
G
Q
R
-
I
D
L
H
L
L
A
L
E
K
M
G
A
N
I
Q
I
K
Q
G
Y
V
V
A
S
G
---
N
L
K
G
N
E
I
L
F
D
K
I
T
V
T
G
S
E
N
I
I
M
A
A
A
L
A
K
G
K
T
K
L
L
N
V
A
K
E
P
E
V
V
Q
L
C
E
V
L
K
D
A
G
L
E
I
K
G
I
G
T
D
E
L
E
I
Y
G
S
DG
E
-
L
L
-
E
F
K
E
F
S
V
I
P
D
R
I
E
A
G
T
Y
L
C
A
G
A
I
T
N
S
K
-
I
T
L
D
K
V
N
A
T
H
-
L
S
A
V
L
A
K
L
H
Q
M
G
F
E
T
L
I
T
E
D
S
I
T
L
L
P
A
-
K
-
E
I
-
K
P
V
E
I
M
T
S
E
Y
P
G
F
P
T
D
M
Q
A
Q
F
M
A
L
A
L
K
A
N
G
T
S
--
I
I
D
E
R
L
--
N
R
F
M
H
V
S
E
L
L
R
M
G
A
D
I
K
-
L
N
G
H
I
A
T
I
V
G
G
K
E
-
L
N
A
A
D
V
M
A
-
T
D
L
R
A
S
S
A
L
I
L
A
A
L
A
A
K
G
T
S
K
V
H
R
I
Y
H
L
D
R
G
Y
E
N
L
E
E
K
F
K
D
L
G
A
K
I
T
R
L
E
E
47
HHSearch
69.76
38%
-55
- C8 -
-
5UJS
-
MURA_CAMJE
B:
[25-441]
M
T
Y
L
E
I
E
G
T
N
H
L
S
G
N
V
T
I
S
G
A
K
N
A
A
L
P
L
I
V
S
S
-
I
L
A
K
N
-
E
V
K
I
N
N
V
P
N
V
A
D
I
K
T
L
I
S
L
L
E
N
L
G
A
K
V
N
F
-
Q
N
N
S
A
L
L
N
T
N
T
L
N
Q
T
I
A
K
Y
D
I
V
R
K
M
R
A
S
I
L
-
T
L
G
P
L
L
A
R
F
G
H
C
E
V
S
L
P
G
G
C
A
I
G
Q
R
P
I
D
L
H
L
L
A
L
E
K
M
G
A
N
I
Q
I
K
-
Q
G
Y
V
-
V
A
S
-
G
N
L
K
G
N
E
I
L
F
D
K
I
T
V
T
G
S
E
N
I
I
M
A
A
A
L
A
K
G
K
T
K
L
L
N
V
A
K
E
P
E
V
V
Q
L
C
E
V
L
K
D
A
G
L
E
I
K
G
I
G
T
D
E
L
E
I
Y
G
S
--
D
G
E
L
L
E
F
K
E
F
S
V
I
P
D
R
I
E
A
G
T
Y
L
C
A
G
A
I
T
N
S
K
-
I
T
L
D
K
V
N
A
T
H
-
L
S
A
V
L
A
K
L
H
Q
M
G
F
E
T
L
I
T
E
D
S
I
T
L
L
P
A
-
K
-
E
I
-
K
P
V
E
I
M
T
S
E
Y
P
G
F
P
T
D
M
Q
A
Q
F
M
A
L
A
L
K
A
N
G
T
S
--
I
I
D
E
R
L
F
E
N
R
F
M
H
V
S
E
L
L
R
M
G
A
D
I
K
L
N
G
H
I
A
-
T
I
V
G
G
K
E
-
L
N
A
A
D
V
-
M
A
T
D
L
R
A
S
S
A
L
I
L
A
A
L
A
A
K
G
T
S
K
V
H
R
I
Y
H
L
D
R
G
Y
E
N
L
E
E
K
F
K
D
L
G
A
K
I
T
R
L
E
-
48
HHSearch
69.61
38%
-57
- C8 -
-
5UJS
-
MURA_CAMJE
A:
[25-441]
M
T
Y
L
E
I
E
G
T
N
H
L
S
G
N
V
T
I
S
G
A
K
N
A
A
L
P
L
I
V
S
S
-
I
L
A
K
N
-
E
V
K
I
N
N
V
P
N
V
A
D
I
K
T
L
I
S
L
L
E
N
L
G
A
K
V
N
F
-
Q
N
N
S
A
L
L
N
T
N
T
L
N
Q
T
I
A
K
Y
D
I
V
R
K
M
R
A
S
I
L
-
T
L
G
P
L
L
A
R
F
G
H
C
E
V
S
L
P
G
G
C
A
I
G
Q
R
-
I
D
L
H
L
L
A
L
E
K
M
G
A
N
I
Q
I
K
-
Q
G
Y
V
-
V
A
S
-
G
N
L
K
G
N
E
I
L
F
D
K
I
T
V
T
G
S
E
N
I
I
M
A
A
A
L
A
K
G
K
T
K
L
L
N
V
A
K
E
P
E
V
V
Q
L
C
E
V
L
K
D
A
G
L
E
I
K
G
I
G
T
D
E
L
E
I
Y
G
S
--
D
G
E
L
L
E
F
K
E
F
S
V
I
P
D
R
I
E
A
G
T
Y
L
C
A
G
A
I
T
N
S
K
-
I
T
L
D
K
V
N
A
T
H
-
L
S
A
V
L
A
K
L
H
Q
M
G
F
E
T
L
I
T
E
D
S
I
T
L
L
P
A
-
K
-
E
I
-
K
P
V
E
I
M
T
S
E
Y
P
G
F
P
T
D
M
Q
A
Q
F
M
A
L
A
L
K
A
N
G
T
S
--
I
I
D
E
R
L
--
N
R
F
M
H
V
S
E
L
L
R
M
G
A
D
I
K
L
N
G
H
I
A
-
T
I
V
G
G
K
E
-
L
N
A
A
D
V
-
M
A
T
D
L
R
A
S
S
A
L
I
L
A
A
L
A
A
K
G
T
S
K
V
H
R
I
Y
H
L
D
R
G
Y
E
N
L
E
E
K
F
K
D
L
G
A
K
I
T
R
L
E
-
11
PsiBlast_PDB
68.70
43%
-15
- C8 -
-
3R38
-
MURA1_LISMO
A:
[25-442]
M
E
K
I
I
V
R
G
G
K
Q
L
N
G
S
V
K
M
E
G
A
K
N
A
V
L
P
V
I
A
A
T
-
L
L
A
S
K
G
T
S
V
L
K
N
V
P
N
L
S
D
V
F
T
I
N
E
V
L
K
Y
L
N
A
D
V
S
F
-
V
N
D
E
V
T
V
D
A
T
G
E
I
T
S
D
A
P
F
E
Y
V
R
K
M
R
A
S
I
V
-
V
M
G
P
L
L
A
R
T
G
S
A
R
V
A
L
P
G
G
C
A
I
G
S
R
P
V
D
L
H
L
K
G
F
E
A
M
G
A
V
V
K
I
E
N
G
Y
I
E
A
T
A
E
K
--
L
V
G
A
K
V
Y
L
D
F
P
S
V
G
A
T
Q
N
I
M
M
A
A
T
L
A
E
G
T
T
V
I
E
N
V
A
R
E
P
E
I
V
D
L
A
N
F
L
N
Q
M
G
A
R
V
I
G
A
G
T
E
V
I
R
I
E
G
V
--
K
-
E
L
-
T
A
T
E
H
S
I
I
P
D
R
I
E
A
G
T
F
M
I
A
A
A
I
T
G
G
N
-
V
L
I
E
D
A
V
P
E
H
-
I
S
S
L
I
A
K
L
E
E
M
G
V
Q
I
I
E
E
--
G
I
R
V
I
G
P
-
D
-
K
L
-
K
A
V
D
V
K
T
M
P
H
P
G
F
P
T
D
M
Q
S
Q
M
M
V
I
Q
M
L
S
E
G
T
S
--
I
M
T
E
T
V
F
E
N
R
F
M
H
V
E
E
M
R
R
M
N
A
D
M
K
I
E
G
H
S
V
-
I
I
S
G
P
A
K
-
L
Q
G
A
E
V
A
A
-
T
D
L
R
A
A
A
A
L
I
L
A
G
L
V
A
D
G
Y
T
Q
V
T
E
L
K
Y
L
D
R
G
Y
N
N
F
H
G
K
L
Q
A
L
G
A
D
V
E
R
V
D
D
58
HHSearch
68.68
96%
-
- C8 -
-
3ZH3
-
MURA1_STRP2
A:
[1-419]
M
R
K
I
V
I
N
G
G
L
P
L
Q
G
E
I
T
I
S
G
A
K
N
S
-
V
V
A
L
I
P
A
I
I
L
A
D
D
-
V
V
T
L
D
C
V
P
D
I
S
D
V
A
S
L
V
E
I
M
E
L
M
G
A
T
V
K
R
-
Y
D
D
V
L
E
I
D
P
R
G
V
Q
N
I
P
M
P
Y
-
G
K
I
N
S
L
R
A
S
Y
Y
F
Y
G
S
L
L
G
R
F
G
E
A
T
V
G
L
P
-------
R
P
I
D
L
H
L
K
A
F
E
A
M
G
A
T
A
S
Y
E
G
D
N
M
K
L
S
A
K
D
T
G
L
H
G
A
S
I
Y
M
D
T
V
S
V
G
A
T
I
N
T
M
I
A
A
V
K
A
N
G
R
T
I
I
E
N
A
A
R
E
P
E
I
I
D
V
A
T
L
L
N
N
M
G
A
H
I
R
G
A
G
T
N
I
I
I
I
D
G
V
--
E
-
R
L
-
H
G
T
R
H
Q
V
I
P
D
R
I
E
A
G
T
Y
I
S
L
A
A
A
V
G
K
G
-
I
R
I
N
N
V
L
Y
E
H
-
L
E
G
F
I
A
K
L
E
E
M
G
V
R
M
T
V
S
E
D
S
I
F
V
E
E
Q
-
S
-
N
L
-
K
A
I
N
I
K
T
A
P
Y
P
G
F
A
T
D
L
Q
Q
P
L
T
P
L
L
L
R
A
N
G
R
G
--
T
I
V
D
T
I
Y
E
K
R
V
N
H
V
F
E
L
A
K
M
D
A
D
I
S
T
T
N
G
H
I
-
L
Y
T
G
G
R
D
-
L
R
G
A
S
V
K
A
-
T
D
L
R
A
G
A
A
L
V
I
A
G
L
M
A
E
G
K
T
E
I
T
N
I
E
F
I
L
R
G
Y
S
D
I
I
E
K
L
R
N
L
G
A
D
I
R
L
V
E
D
14
PsiBlast_PDB
68.51
41%
-24
- C8 -
-
2RL2
2
MURA_HAEIN
A:
[1-415]
M
D
K
F
R
V
Y
G
Q
S
R
L
S
G
S
V
N
I
S
G
A
K
N
A
A
L
P
I
L
F
A
A
-
I
L
A
T
E
-
P
V
K
L
T
N
V
P
E
L
K
D
I
E
T
T
L
K
I
L
R
Q
L
G
V
V
V
D
R
D
A
T
G
A
V
L
L
D
A
S
N
I
N
H
F
T
A
P
Y
E
L
V
K
T
M
R
A
S
I
W
-
A
L
A
P
L
V
A
R
F
H
Q
G
Q
V
S
L
P
G
G
C
S
I
G
A
R
P
V
D
L
H
I
S
G
L
E
K
L
G
A
D
I
V
L
E
E
G
Y
V
K
A
Q
V
S
D
R
-
L
V
G
T
R
I
V
I
E
K
V
S
V
G
A
T
L
S
I
M
M
A
A
T
L
A
K
G
T
T
V
I
E
N
A
A
R
E
P
E
I
V
D
T
A
D
F
L
N
K
M
G
A
K
I
T
G
A
G
S
A
H
I
T
I
E
G
V
--
E
-
R
L
-
T
G
C
E
H
S
V
V
P
D
R
I
E
T
G
T
F
L
I
A
A
A
I
S
G
G
C
-
V
V
C
Q
N
T
K
A
D
T
-
L
D
A
V
I
D
K
L
R
E
A
G
A
Q
V
D
V
T
E
N
S
I
T
L
D
M
L
-
G
-
N
R
P
K
A
V
N
I
R
T
A
P
H
P
G
F
P
T
D
M
Q
A
Q
F
T
L
L
N
M
V
A
E
G
T
S
--
I
I
T
E
T
I
F
E
N
R
F
M
H
I
P
E
L
I
R
M
G
G
K
A
E
I
E
G
N
T
A
-
V
C
H
G
V
E
Q
-
L
S
G
T
E
V
I
A
-
T
D
L
R
A
S
I
S
L
V
L
A
G
C
I
A
T
G
E
T
I
V
D
R
I
Y
H
I
D
R
G
Y
E
H
I
E
D
K
L
R
G
L
G
A
K
I
-----
13
PsiBlast_PDB
68.27
41%
-25
- C8 -
-
2RL1
1
MURA_HAEIN
A:
[1-415]
M
D
K
F
R
V
Y
G
Q
S
R
L
S
G
S
V
N
I
S
G
A
K
N
A
A
L
P
I
L
F
A
A
-
I
L
A
T
E
-
P
V
K
L
T
N
V
P
E
L
K
D
I
E
T
T
L
K
I
L
R
Q
L
G
V
V
V
D
R
D
A
T
G
A
V
L
L
D
A
S
N
I
N
H
F
T
A
P
Y
E
L
V
K
T
M
R
A
S
I
W
-
A
L
A
P
L
V
A
R
F
H
Q
G
Q
V
S
L
P
G
G
C
S
I
G
A
R
P
V
D
L
H
I
S
G
L
E
K
L
G
A
D
I
V
L
E
E
G
Y
V
K
A
Q
V
S
D
R
-
L
V
G
T
R
I
V
I
E
K
V
S
V
G
A
T
L
S
I
M
M
A
A
T
L
A
K
G
T
T
V
I
E
N
A
A
R
E
P
E
I
V
D
T
A
D
F
L
N
K
M
G
A
K
I
T
G
A
G
S
A
H
I
T
I
E
G
V
--
E
-
R
L
-
T
G
C
E
H
S
V
V
P
D
R
I
E
T
G
T
F
L
I
A
A
A
I
S
G
G
C
-
V
V
C
Q
N
T
K
A
D
T
-
L
D
A
V
I
D
K
L
R
E
A
G
A
Q
V
D
V
T
E
N
S
I
T
L
D
M
L
-
G
-
N
R
P
K
A
V
N
I
R
T
A
P
H
P
G
F
P
T
D
M
Q
A
Q
F
T
L
L
N
M
V
A
E
G
T
S
--
I
I
T
E
T
I
F
E
N
R
F
M
H
I
P
E
L
I
R
M
G
G
K
A
E
I
E
G
N
T
A
-
V
C
H
G
V
E
Q
-
L
S
G
T
E
V
I
A
-
T
D
L
R
A
S
I
S
L
V
L
A
G
C
I
A
T
G
E
T
I
V
D
R
I
Y
H
I
D
R
G
Y
E
H
I
E
D
K
L
R
G
L
G
A
K
I
-----