@TOME V2.3
(Mar 2018)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : spr0995: (2018-01-02 )
MNALLNGMNDRQAEAVQTTEGPLLIMAGAGSGKTRVLTHRIAYLIDEKLVNPWNILAITFTNKAAREMKERAYSLNPATQDCLIATFHSMCVRILRRDADHIGYNRNFTIVDPGEQRTLMKRILKQLNLDPKKWNERTILGTISNAKNDLIDDVAYAAQAGDMYTQIVAQCYTAYQKELRQSESVDFDDLIMLTLRLFDQNPDVLTYYQQKFQYIHVDEYQDTNHAQYQLVKLLASRFKNICVVGDADQSIYGWRGADMQNILDFEKDYPKAKVVLLEENYRSTKTILQAANEVIKNNKNRRPKNLWTQNADGEQIVYYRADDELDEAVFVARTIDELSRSQNFLHKDFAVLYRTNAQSRTIEEALLKSNIPYTMVGGTKFYSRKEIRDIIAYLNLIANLSDNISFERIINEPKRGIGLGTVEKIRDFANLQNMSMLDASANIMLSGIKGKAAQSIWDFANMMLDLREQLDHLSITELVESVLEKTGYVDILNAQATLESKARVENIEEFLSVTKNFDDTTDVTEEETGLDKLSRFLNDLALIADTDSGSQETSEVTLMTLHAAKGLEFPVVFLIGMEENVFPLSRATEDPDELEEERRLAYVGITRAEKILYLTNANSRLLFGRTNYNRPTRFINEISSDLLEYQGLARPANTSFKASYSSGSISFGQGMSLAQALQDRKRGAAPKSIQSSGLPFGQFTAGAKPASSEANWSIGDIALHKKWGEGTVLEVSGSGARQELKINFPEVGLKKLLASVAPIEKKI
Atome Classification :
(22 SA)
.........10........20........30........40.......--.50........60........70....--..--.----------------.80..-......90........100...--....110.......120.......130----------------------------------------........140-----------------------.....-------------------------------.----------------------------...150......------...--------160-------------.------........170.......180.......190.......200-------........210.......220.......230.....---..240.......250.......260.......270---.........280.......290.......300...--------..--..--310...-------....320.......330.......340-----------....----....350.......360.......370.......380.......390.......400.......410.......420.......430.......440..-.-.-...450.......460.......470.......480.......490--....--...500.......510.......520.......530.-....-...540.....--------.---.550...---....560.......570.......580.....-.-----------------------------------.-590.......600.......610.......620.......630.......640..-----.....650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750.......760.
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
M
N
A
L
LNGMNDRQA
E
A
V
QTTEG
P
L
L
I
M
A
GAGSG
K
T
R
V
L
T
H
R
I
A
Y
L
I
D
E
K--LVNP
W
N
I
L
A
I
T
FT
N
K
A
A
R
E
M
K
E
RAYSL--NP--A----------------
T
Q
D
C
L
-
I
A
T
F
H
S
M
C
V
R
I
L
RRD
A
D
HIGYN--R
N
F
T
I
VDPG
E
Q
R
T
L
M
K
R
I
L
K
QLNLDP-----------------------------------------KKWNE
R
T
I
L
-------------------------
G
TISN-------------------------------A----------------------------KN
D
L
--
I
D
D
V
A
Y
------
A
AQ--------A---------------
G
------
D
M
Y
T
Q
I
V
A
Q
C
Y
T
A
Y
Q
K
E
L
R
QSESV
D
F
D
D
L
I
M
L
T
L
R
L
FDQN--------P
D
V
L
T
Y
Y
Q
Q
K
F
Q
Y
I
H
VDEYQDT
N
H
A
Q
Y
Q
L
V
K
L
L
A
S
R
---FK
N
I
C
V
VGDADQSIYGWRGA
D
M
Q
N
I
L
D
F
E
KDYP-----K
A
K
V
V
L
L
EENY
R
S
T
K
T
I
L
Q
A
A
N
E
V
I
KNNKNRRPKN--------LW--TQ--NADG
E
Q
-------
I
V
Y
Y
RADDE
L
D
E
A
V
F
V
A
R
T
I
D
E
L
S
R
S
------------
Q
N
F
L
----
H
K
D
F
A
V
L
YRTNAQS
R
T
I
E
E
A
L
L
KSNI
P
Y
T
MVGGTKFY
S
R
K
E
I
R
D
I
I
A
Y
L
N
L
I
A
NLSDNI
S
F
E
R
I
INEPKRGIGL
G
T
V
E
K
I
R
D
F
A
NLQN
M
S
MLDASA
N
I
M
-
L
-S-GIKG
K
A
A
Q
S
I
W
D
F
A
N
M
M
L
D
L
R
E
QLDH
L
S
I
T
E
L
V
E
S
V
L
E
KTG
Y
V
D
I
L--NAQA--T
L
E
S
K
A
R
V
E
N
I
E
E
F
L
S
V
TKNFDDTTDV
T
E
E
E
T
G
L
-
D
K
-
L
S
R
F
-
L
N
D
L
A
L
I
ADTD--------S---GSQET
S
E
---
V
T
L
M
T
L
HAAKGLEF
P
V
V
F
L
I
GMEENVFPLSRA-T-----------------------------------E-
D
P
D
E
L
E
E
ER
R
L
A
Y
V
GITR
A
E
K
I
L
Y
L
TNAN
S
R
L
L
F
GRTNYN
R
P
T
R
F
I
N
E
I
S
S
D
L
L
E
-----
Y
QGLARPANT
S
F
K
A
SYSSGSISFGQG
M
S
L
A
Q
A
L
Q
D
R
KRGAAPKSIQSSGLPFGQFTAGAKPASSEANWSIG
D
I
A
L
H
KKWGEG
T
V
L
E
VSGSGA
R
Q
E
L
K
INF
P
E
V
G
L
K
K
L
L
A
S
VAPIEKKI
1
PsiBlast_PDB
85.68
55%
-3
- C4 -
-
3PJR
2
?
A:
[8-652]
---
L
L
A
H
L
N
K
E
Q
Q
E
A
V
R
T
T
E
G
P
L
L
I
M
A
G
A
G
S
G
K
T
R
V
L
T
H
R
I
A
Y
L
M
A
E
K
--
H
V
A
P
W
N
I
L
A
I
T
F
T
N
K
A
A
R
E
M
R
E
R
V
Q
S
L
L
-
G
G
--
A
----------------
A
E
D
V
W
-
I
S
T
F
H
S
M
C
V
R
I
L
R
R
D
I
D
R
I
G
I
N
--
R
N
F
S
I
L
D
P
T
D
Q
L
S
V
M
K
T
I
L
K
E
K
N
I
D
P
-----------------------------------------
K
K
F
E
P
R
T
I
L
-------------------------
G
T
I
S
A
-------------------------------
A
----------------------------
K
N
E
L
--
L
P
P
E
Q
F
------
A
K
R
--------
A
---------------
S
------
T
Y
Y
E
K
V
V
S
D
V
Y
Q
E
Y
Q
Q
R
L
L
R
N
H
S
L
D
F
D
D
L
I
M
T
T
I
Q
L
F
D
R
V
--------
P
D
V
L
H
Y
Y
Q
Y
K
F
Q
Y
I
H
I
D
E
Y
Q
D
T
N
R
A
Q
Y
T
L
V
K
K
L
A
E
R
---
F
Q
N
I
C
A
V
G
D
A
D
Q
S
I
Y
R
W
R
G
A
D
I
Q
N
I
L
S
F
E
R
D
Y
P
-----
N
A
K
V
I
L
L
E
Q
N
Y
R
S
T
K
R
I
L
Q
A
A
N
E
V
I
E
H
N
V
N
R
K
P
K
R
--------
I
W
--
T
E
--
N
P
E
G
K
P
-------
I
L
Y
Y
E
A
M
N
E
A
D
E
A
Q
F
V
A
G
R
I
R
E
A
V
E
R
------------
G
E
R
R
----
Y
R
D
F
A
V
L
Y
R
T
N
A
Q
S
R
V
M
E
E
M
L
L
K
A
N
I
P
Y
Q
I
V
G
G
L
K
F
Y
D
R
K
E
I
K
D
I
L
A
Y
L
R
V
I
A
N
P
D
D
D
L
S
L
L
R
I
I
N
V
P
K
R
G
I
G
A
S
T
I
D
K
L
V
R
Y
A
A
D
H
E
L
S
L
F
E
A
L
G
E
L
E
-
M
-
I
-
G
L
G
A
K
A
A
G
A
L
A
A
F
R
S
Q
L
E
Q
W
T
Q
L
Q
E
Y
V
S
V
T
E
L
V
E
E
V
L
D
K
S
G
Y
R
E
M
L
--
K
A
E
R
--
T
I
E
A
Q
S
R
L
E
N
L
D
E
F
L
S
V
T
K
H
F
E
N
V
S
D
---------
D
K
S
L
I
A
F
-
L
T
D
L
A
L
I
S
D
L
D
--------
E
----
T
E
Q
A
A
E
G
D
A
V
M
L
M
T
L
H
A
A
K
G
L
E
F
P
V
V
F
L
I
G
M
E
E
G
I
F
P
H
N
R
S
-
L
-----------------------------------
E
-
D
D
D
E
M
E
E
E
R
R
L
A
Y
V
G
I
T
R
A
E
E
E
L
V
L
T
S
A
Q
M
R
T
L
F
G
N
I
Q
M
D
P
P
S
R
F
L
N
E
I
P
A
H
L
L
E
T
A
S
R
R-----------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
83.28
55%
-2
- C4 -
-
1QHG
1
PCRA_GEOSE
A:
[8-651]
---
L
L
A
H
L
N
K
E
Q
Q
E
A
V
R
T
T
E
G
P
L
L
I
M
A
G
A
G
S
G
K
T
R
V
L
T
H
R
I
A
Y
L
M
A
E
K
--
H
V
A
P
-
N
I
L
A
I
T
F
T
N
K
A
A
R
E
M
R
E
R
V
Q
S
L
L-
G
G
--
A
----------------
A
E
D
V
W
-
I
S
T
F
H
S
M
C
V
R
I
L
R
R
D
I
D
R
I
G
I
N
--
R
N
F
S
I
L
D
P
T
D
Q
L
S
V
M
K
T
I
L
K
E
K
N
I
D
P
-----------------------------------------
K
K
F
E
P
R
T
I
L
-------------------------
G
T
I
S
A
-------------------------------
A
----------------------------
K
N
E
L
--
L
P
P
E
Q
F
------
A
K
R
--------------------------------
Y
Y
E
K
V
V
S
D
V
Y
Q
E
Y
Q
Q
R
L
L
R
N
H
S
L
D
F
D
D
L
I
M
T
T
I
Q
L
F
D
R
V
--------
P
D
V
L
H
Y
Y
Q
Y
K
F
Q
Y
I
H
I
D
E
Y
Q
D
T
N
R
A
Q
Y
T
L
V
K
K
L
A
E
R
---
F
Q
N
I
C
A
V
G
D
A
D
Q
S
I
Y
R
W
R
G
A
D
I
Q
N
I
L
S
F
E
R
D
Y
P
-----
N
A
K
V
I
L
L
E
Q
N
Y
R
S
T
K
R
I
L
Q
A
A
N
E
V
I
E
H
N
V
N
R
K
P
K
R
--------
I
W
--
T
E
--
N
P
E
G
K
P
-------
I
L
Y
Y
E
A
M
N
E
A
D
E
A
Q
F
V
A
G
R
I
R
E
A
V
E
R
------------
G
E
R
R
----
Y
R
D
F
A
V
L
Y
R
T
N
A
Q
S
R
V
M
E
E
M
L
L
K
A
N
I
P
Y
Q
I
V
G
G
L
K
F
Y
D
R
K
E
I
K
D
I
L
A
Y
L
R
V
I
A
N
P
D
D
D
L
S
L
L
R
I
I
N
V
P
K
R
G
I
G
A
S
T
I
D
------------
L
F
E
A
L
G
E
L
E
-
M
-
I
-
G
L
G
A
K
A
A
G
A
L
A
A
F
R
S
Q
L
E
Q
W
T
Q
L
Q
E
Y
V
S
V
T
E
L
V
E
E
V
L
D
K
S
G
Y
R
E
M
L
--
K
A
E
R
--
T
I
E
A
Q
S
R
L
E
N
L
D
E
F
L
S
V
T
K
H
F
E
N
V
S
D
---------
D
K
S
L
I
A
F
-
L
T
D
L
A
L
I
S
----------------------GD
A
V
M
L
M
T
L
H
A
A
K
G
L
E
F
P
V
V
F
L
I
G
M
E
E
G
I
F
P
H
N
R
S
-
L
-----------------------------------
E
-
D
D
D
E
M
E
E
E
R
R
L
A
Y
V
G
I
T
R
A
E
E
E
L
V
L
T
S
A
Q
M
R
T
L
F
G
N
I
Q
M
D
P
P
S
R
F
L
N
E
I
P
A
H
L
L
E
TASR------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
82.90
55%
-1
- C4 -
-
1PJR
-
PCRA_GEOSE
A:
[8-651]
---
L
L
A
H
L
N
K
E
Q
Q
E
A
V
R
T
T
E
G
P
L
L
I
M
A
G
A
G
S
G
K
T
R
V
L
T
H
R
I
A
Y
L
M
A
E
K
--
H
V
A
P
W
N
I
L
A
I
T
F
T
N
K
A
A
R
E
M
R
E
R
V
Q
S
L
L-
G
G
--
A
----------------
A
E
D
V
W
-
I
S
T
F
H
S
M
C
V
R
I
L
R
R
D
I
D
R
I
G
I
N
--
R
N
F
S
I
L
D
P
T
D
Q
L
S
V
M
K
T
I
L
K
E
K
N
I
D
P
-----------------------------------------
K
K
F
E
P
R
T
I
L
-------------------------
G
T
I
S
A
-------------------------------
A
----------------------------
K
N
E
L
--
L
P
P
E
Q
F
------
A
K
R
--------------------------------
Y
Y
E
K
V
V
S
D
V
Y
Q
E
Y
Q
Q
R
L
L
R
N
H
S
L
D
F
D
D
L
I
M
T
T
I
Q
L
F
D
R
V
--------
P
D
V
L
H
Y
Y
Q
Y
K
F
Q
Y
I
H
I
D
E
Y
Q
D
T
N
R
A
Q
Y
T
L
V
K
K
L
A
E
R
---
F
Q
N
I
C
A
V
G
D
A
D
Q
S
I
Y
R
W
R
G
A
D
I
Q
N
I
L
S
F
E
R
D
Y
P
-----
N
A
K
V
I
L
L
E
Q
N
Y
R
S
T
K
R
I
L
Q
A
A
N
E
V
I
E
H
N
V
N
R
K
P
K
R
--------
I
W
--
T
E
--
N
P
E
G
K
P
-------
I
L
Y
Y
E
A
M
N
E
A
D
E
A
Q
F
V
A
G
R
I
R
E
A
V
E
R
------------
G
E
R
R
----
Y
R
D
F
A
V
L
Y
R
T
N
A
Q
S
R
V
M
E
E
M
L
L
K
A
N
I
P
Y
Q
I
V
G
G
L
K
F
Y
D
R
K
E
I
K
D
I
L
A
Y
L
R
V
I
A
N
P
D
D
D
L
S
L
L
R
I
I
N
V
P
K
R
G
I
G
A
S
T
I
D
------------
L
F
E
A
L
G
E
L
E
-
M
-
I
-
G
L
G
A
K
A
A
G
A
L
A
A
F
R
S
Q
L
E
Q
W
T
Q
L
Q
E
Y
V
S
V
T
E
L
V
E
E
V
L
D
K
S
G
Y
R
E
M
L
--
K
A
E
R
--
T
I
E
A
Q
S
R
L
E
N
L
D
E
F
L
S
V
T
K
H
F
E
N
V
S
D
---------
D
K
S
L
I
A
F
-
L
T
D
L
A
L
I
S
----------------------GD
A
V
M
L
M
T
L
H
A
A
K
G
L
E
F
P
V
V
F
L
I
G
M
E
E
G
I
F
P
H
N
R
S
-
L
-----------------------------------
E
-
D
D
D
E
M
E
E
E
R
R
L
A
Y
V
G
I
T
R
A
E
E
E
L
V
L
T
S
A
Q
M
R
T
L
F
G
N
I
Q
M
D
P
P
S
R
F
L
N
E
I
P
A
H
L
L
E
TASR------------------------------------------------------------------------------------------------------------------------
22
PsiBlast_CBE
80.31
40%
-1
- C4 -
-
4C2T
1
?
C:
[9-662]
---
L
L
Q
A
L
N
P
T
Q
A
Q
A
A
D
H
F
T
G
P
A
L
V
I
A
G
A
G
S
G
K
T
R
T
L
I
Y
R
I
A
H
L
I
G
H
Y
--
G
V
H
P
G
E
I
L
A
V
T
F
T
N
K
A
A
A
E
M
R
E
R
A
G
H
L
--
V
P
--
G
----------------
A
G
D
L
W
-
M
S
T
F
H
S
A
G
V
R
I
L
R
T
Y
G
E
H
I
G
L
R
--
R
G
F
V
I
Y
D
D
D
D
Q
L
D
I
I
K
E
V
M
G
S
I
P
G
I
G
-----------------------------------------
A
E
T
Q
P
R
V
I
R
-------------------------
G
I
I
D
R
-------------------------------
A
----------------------------
K
S
N
L
WT
P
D
D
L
D
R
------
S
R
E
--------
P
FI-------------
S
------
G
L
P
R
D
A
A
A
E
A
Y
R
R
Y
E
V
R
K
K
G
Q
N
A
I
D
F
G
D
L
I
T
E
T
V
R
L
F
K
E
V
--------
P
G
V
L
D
K
V
Q
N
K
A
K
F
I
H
V
D
E
Y
Q
D
T
N
R
A
Q
Y
E
L
T
R
L
L
A
S
R
---
D
R
N
L
L
V
V
G
D
P
D
Q
S
I
Y
K
F
R
G
A
D
I
Q
N
I
L
D
F
Q
K
D
Y
P
-----
D
A
K
V
Y
M
L
E
H
N
Y
R
S
S
A
R
V
L
E
A
A
N
K
L
I
E
N
N
T
E
R
L
D
K
T
--------
L
K
--
P
V
--
K
E
A
G
Q
P
-------
V
T
F
H
R
A
T
D
H
R
A
E
G
D
Y
V
A
D
W
L
T
R
L
-
H
G
------------
E
G
R
A
----
W
S
E
M
A
I
L
Y
R
T
N
A
Q
S
R
V
I
E
E
S
L
R
R
V
Q
I
P
-
R
I
V
G
G
V
G
F
Y
D
R
R
E
I
R
D
I
L
A
Y
A
R
L
A
L
N
P
A
D
D
V
A
L
R
R
I
I
G
R
P
R
R
G
I
G
D
T
A
L
Q
K
L
M
E
W
A
R
T
H
H
T
S
V
L
T
A
C
A
N
A
A
-
E
-
Q
-
N
I
L
D
R
G
A
H
K
A
T
E
F
A
G
L
M
E
A
M
S
E
A
A
D
N
Y
E
P
A
A
F
L
R
F
V
M
E
T
S
G
Y
L
D
L
L
--
R
-
Q
E
----
E
G
Q
V
R
L
E
N
L
E
E
L
V
S
A
A
E
E
W
S
Q
-----
D
E
A
N
----
S
-
I
A
D
F
-
L
D
D
A
A
L
L
S
S
V
D
D
M
R
T
K
A
E-------
P
E
D
A
----
V
T
L
M
T
L
H
N
A
K
G
L
E
F
P
V
V
F
I
V
G
V
E
Q
G
L
L
P
S
K
G
A
I
A
-----------------------------------
E
-
G
P
S
G
I
E
E
E
R
R
L
F
Y
V
G
I
T
R
A
M
E
R
L
L
M
T
A
A
Q
N
R
M
Q
F
G
K
T
N
A
A
E
D
S
A
F
L
E
D
I
------------
E
G
L
F
D
T
V
D
------------
P
Y
G
Q
P
I
--------------------------------------------------------------------------------------------
27
PsiBlast_CBE
79.89
43%
-8
- C4 -
-
4C2U
2
?
D:
[9-648]
---
L
L
Q
A
L
N
P
T
Q
A
Q
A
A
D
H
F
T
G
P
A
L
V
I
A
G
A
G
S
G
K
T
R
T
L
I
Y
R
I
A
H
L
I
G
H
Y
--
G
V
H
P
G
E
I
L
A
V
T
F
T
N
K
A
A
A
E
M
R
E
R
A
G
H
L
--
V
P
--
G
----------------
A
G
D
L
W
-
M
S
T
F
H
S
A
G
V
R
I
L
R
T
Y
G
E
H
I
G
L
R
--
R
G
F
V
I
Y
D
D
D
D
Q
L
D
I
I
K
E
V
M
G
S
I
P
G
--------------------------------------------
E
T
Q
P
R
V
I
R
-------------------------
G
I
I
D
R
-------------------------------
A
----------------------------
K
S
N
L
WT
P
D
D
L
D
R
------
S
R
E
--------
P
FI-------------
S
------
G
L
P
R
D
A
A
A
E
A
Y
R
R
Y
E
V
R
K
K
G
Q
N
A
I
D
F
G
D
L
I
T
E
T
V
R
L
F
K
E
V
--------
P
G
V
L
D
K
V
Q
N
K
A
K
F
I
H
V
D
E
Y
Q
D
T
N
R
A
Q
Y
E
L
T
R
L
L
A
S
R
---
D
R
N
L
L
V
V
G
D
P
D
Q
S
I
Y
K
F
R
G
A
D
I
Q
N
I
L
D
F
Q
K
D
Y
P
-----
D
A
K
V
Y
M
L
E
H
N
Y
R
S
S
A
R
V
L
E
A
A
N
K
L
I
E
N
N
T
E
R
L
D
K
T
--------
L
K
--
P
V
--
K
E
A
G
Q
P
-------
V
T
F
H
R
A
T
D
H
R
A
E
G
D
Y
V
A
D
W
L
T
R
L
-
H
G
------------
E
G
R
A
----
W
S
E
M
A
I
L
Y
R
T
N
A
Q
S
R
V
I
E
E
S
L
R
R
V
Q
I
P
A
R
I
V
G
G
V
G
F
Y
D
R
R
E
I
R
D
I
L
A
Y
A
R
L
A
L
N
P
A
D
D
V
A
L
R
R
I
I
G
R
P
R
R
G
I
G
D
T
A
L
Q
K
L
M
E
W
A
R
T
H
H
T
S
V
L
T
A
C
A
N
A
A
-
E
-
Q
-
N
I
L
D
R
G
A
H
K
A
T
E
F
A
G
L
M
E
A
M
S
E
A
A
D
N
Y
E
P
A
A
F
L
R
F
V
M
E
T
S
G
Y
L
D
L
L
--
R
-
Q
E
--
G
Q
E
G
Q
V
R
L
E
N
L
E
E
L
V
S
A
A
E
E
W
------
S
Q
D
E
A
N
V
G
G
S
-
I
A
D
F
-
L
D
D
A
A
L
L
S
S
V
D
DMRTKAEN
K
---
G
A
P
E
D
A
----
V
T
L
M
T
L
H
N
A
K
G
L
E
F
P
V
V
F
I
V
G
V
E
Q
G
L
L
P
S
K
G
A
I
A
-----------------------------------
E
-
G
P
S
G
I
E
E
E
R
R
L
F
Y
V
G
I
T
R
A
M
E
R
L
L
M
T
A
A
Q
N
R
M
Q
F
G
K
T
N
A
A
E
D
S
A
F
L
E
D
I
----------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
79.77
43%
-6
- C4 -
-
4C2U
2
?
A:
[9-648]
---
L
L
Q
A
L
N
P
T
Q
A
Q
A
A
D
H
F
T
G
P
A
L
V
I
A
G
A
G
S
G
K
T
R
T
L
I
Y
R
I
A
H
L
I
G
H
Y
--
G
V
H
P
G
E
I
L
A
V
T
F
T
N
K
A
A
A
E
M
R
E
R
A
G
H
L
--
V
P
--
G
----------------
A
G
D
L
W
-
M
S
T
F
H
S
A
G
V
R
I
L
R
T
Y
G
E
H
I
G
L
R
--
R
G
F
V
I
Y
D
D
D
D
Q
L
D
I
I
K
E
V
M
G
S
I
P
G
--------------------------------------------
E
T
Q
P
R
V
I
R
-------------------------
G
I
I
D
R
-------------------------------
A
----------------------------
K
S
N
L
WT
P
D
D
L
D
R
------
S
R
E
--------
P
FI-------------
S
------
G
L
P
R
D
A
A
A
E
A
Y
R
R
Y
E
V
R
K
K
G
Q
N
A
I
D
F
G
D
L
I
T
E
T
V
R
L
F
K
E
V
--------
P
G
V
L
D
K
V
Q
N
K
A
K
F
I
H
V
D
E
Y
Q
D
T
N
R
A
Q
Y
E
L
T
R
L
L
A
S
R
---
D
R
N
L
L
V
V
G
D
P
D
Q
S
I
Y
K
F
R
G
A
D
I
Q
N
I
L
D
F
Q
K
D
Y
P
-----
D
A
K
V
Y
M
L
E
H
N
Y
R
S
S
A
R
V
L
E
A
A
N
K
L
I
E
N
N
T
E
R
L
D
K
T
--------
L
K
--
P
V
--
K
E
A
G
Q
P
-------
V
T
F
H
R
A
T
D
H
R
A
E
G
D
Y
V
A
D
W
L
T
R
L
-
H
G
------------
E
G
R
A
----
W
S
E
M
A
I
L
Y
R
T
N
A
Q
S
R
V
I
E
E
S
L
R
R
V
Q
I
P
A
R
I
V
G
G
V
G
F
Y
D
R
R
E
I
R
D
I
L
A
Y
A
R
L
A
L
N
P
A
D
D
V
A
L
R
R
I
I
G
R
P
R
R
G
I
G
D
T
A
L
Q
K
L
M
E
W
A
R
T
H
H
T
S
V
L
T
A
C
A
N
A
A
-
E
-
Q
-
N
I
L
D
R
G
A
H
K
A
T
E
F
A
G
L
M
E
A
M
S
E
A
A
D
N
Y
E
P
A
A
F
L
R
F
V
M
E
T
S
G
Y
L
D
L
L
--
R
-
Q
E
--
G
Q
E
G
Q
V
R
L
E
N
L
E
E
L
V
S
A
A
E
E
W
------
S
Q
D
E
A
N
V
G
G
S
-
I
A
D
F
-
L
D
D
A
A
L
L
S
S
V
D
D
M
R
T
K
A
E
N
K
---
G
A
P
E
D
A
----
V
T
L
M
T
L
H
N
A
K
G
L
E
F
P
V
V
F
I
V
G
V
E
Q
G
L
L
P
S
K
G
A
I
A
-----------------------------------
E
-
G
P
S
G
I
E
E
E
R
R
L
F
Y
V
G
I
T
R
A
M
E
R
L
L
M
T
A
A
Q
N
R
M
Q
F
G
K
T
N
A
A
E
D
S
A
F
L
E
D
I
----------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
79.76
40%
-7
- C4 -
-
4C2T
1
?
A:
[9-662]
---
L
L
Q
A
L
N
P
T
Q
A
Q
A
A
D
H
F
T
G
P
A
L
V
I
A
G
A
G
S
G
K
T
R
T
L
I
Y
R
I
A
H
L
I
G
H
Y
--
G
V
H
P
G
E
I
L
A
V
T
F
T
N
K
A
A
A
E
M
R
E
R
A
G
H
L
--
V
P
--
G
----------------
A
G
D
L
W
-
M
S
T
F
H
S
A
G
V
R
I
L
R
T
Y
G
E
H
I
G
L
R
--
R
G
F
V
I
Y
D
D
D
D
Q
L
D
I
I
K
E
V
M
G
S
I
P
G
I
G
-----------------------------------------
A
E
T
Q
P
R
V
I
R
-------------------------
G
I
I
D
R
-------------------------------
A
----------------------------
K
S
N
L
WT
P
D
D
L
D
R
------
S
R
E
--------
P
FI-------------
S
------
G
L
P
R
D
A
A
A
E
A
Y
R
R
Y
E
V
R
K
K
G
Q
N
A
I
D
F
G
D
L
I
T
E
T
V
R
L
F
K
E
V
--------
P
G
V
L
D
K
V
Q
N
K
A
K
F
I
H
V
D
E
Y
Q
D
T
N
R
A
Q
Y
E
L
T
R
L
L
A
S
R
---
D
R
N
L
L
V
V
G
D
P
D
Q
S
I
Y
K
F
R
G
A
D
I
Q
N
I
L
D
F
Q
K
D
Y
P
-----
D
A
K
V
Y
M
L
E
H
N
Y
R
S
S
A
R
V
L
E
A
A
N
K
L
I
E
N
N
T
E
R
L
D
K
T
--------
L
K
--
P
V
--
K
E
A
G
Q
P
-------
V
T
F
H
R
A
T
D
H
R
A
E
G
D
Y
V
A
D
W
L
T
R
L
-
H
G
------------
E
G
R
A
----
W
S
E
M
A
I
L
Y
R
T
N
A
Q
S
R
V
I
E
E
S
L
R
R
V
Q
I
P
A
R
I
V
G
G
V
G
F
Y
D
R
R
E
I
R
D
I
L
A
Y
A
R
L
A
L
N
P
A
D
D
V
A
L
R
R
I
I
G
R
P
R
R
G
I
G
D
T
A
L
Q
K
L
M
E
W
A
R
T
H
H
T
S
V
L
T
A
C
A
N
A
A
-
E
-
Q
-
N
I
L
D
R
G
A
H
K
A
T
E
F
A
G
L
M
E
A
M
S
E
A
A
D
N
Y
E
P
A
A
F
L
R
F
V
M
E
T
S
G
Y
L
D
L
L
--
R
-
Q
E
--
G
Q
E
G
Q
V
R
L
E
N
L
E
E
L
V
S
A
A
E
E
W
S
Q
-----
D
E
A
N
V
G
-
G
S
-
I
A
D
F
-
L
D
D
A
A
L
L
S
S
--DMRTKA---------
E
D
A
----
V
T
L
M
T
L
H
N
A
K
G
L
E
F
P
V
V
F
I
V
G
V
E
Q
G
L
L
P
S
K
G
A
I
A
-----------------------------------
E
-
G
P
S
G
I
E
E
E
R
R
L
F
Y
V
G
I
T
R
A
M
E
R
L
L
M
T
A
A
Q
N
R
M
Q
F
G
K
T
N
A
A
E
D
S
A
F
L
E
D
I
------------
E
G
L
F
D
T
V
D
------------
P
Y
G
Q
P
I
--------------------------------------------------------------------------------------------
46
HHSearch
79.45
43%
-6
- C4 -
-
4C2U
2
?
A:
[7-654]
-
P
D
L
L
Q
A
L
N
P
T
Q
A
Q
A
A
D
H
F
T
G
P
A
L
V
I
A
G
A
G
S
G
K
T
R
T
L
I
Y
R
I
A
H
L
I
G
H
Y
--
G
V
H
P
G
E
I
L
A
V
T
F
T
N
K
A
A
A
E
M
R
E
R
A
G
H
L
--
V
P
--
G
----------------
A
G
D
L
W
-
M
S
T
F
H
S
A
G
V
R
I
L
R
T
Y
G
E
H
I
G
L
R
--
R
G
F
V
I
Y
D
D
D
D
Q
L
D
I
I
K
E
V
M
G
S
I
P
G
--------------------------------------------
E
T
Q
P
R
V
I
R
-------------------------
G
I
I
D
R
-------------------------------
A
----------------------------
K
S
N
L
--
W
T
P
D
D
L
------
D
R
S
--------
R
EPFI-----------
S
------
G
L
P
R
D
A
A
A
E
A
Y
R
R
Y
E
V
R
K
K
G
Q
N
A
I
D
F
G
D
L
I
T
E
T
V
R
L
F
K
E
V
--------
P
G
V
L
D
K
V
Q
N
K
A
K
F
I
H
V
D
E
Y
Q
D
T
N
R
A
Q
Y
E
L
T
R
L
L
A
S
R
---
D
R
N
L
L
V
V
G
D
P
D
Q
S
I
Y
K
F
R
G
A
D
I
Q
N
I
L
D
F
Q
K
D
Y
P
-----
D
A
K
V
Y
M
L
E
H
N
Y
R
S
S
A
R
V
L
E
A
A
N
K
L
I
E
N
N
T
E
R
L
D
K
T
--------
L
K
--
P
V
--
K
E
A
G
Q
P
-------
V
T
F
H
R
A
T
D
H
R
A
E
G
D
Y
V
A
D
W
L
T
R
L
H
G
E
-------------
G
R
A
----
W
S
E
M
A
I
L
Y
R
T
N
A
Q
S
R
V
I
E
E
S
L
R
R
V
Q
I
P
A
R
I
V
G
G
V
G
F
Y
D
R
R
E
I
R
D
I
L
A
Y
A
R
L
A
L
N
P
A
D
D
V
A
L
R
R
I
I
G
R
P
R
R
G
I
G
D
T
A
L
Q
K
L
M
E
W
A
R
T
H
H
T
S
V
L
T
A
C
A
N
A
A
-
E
-
Q
-
N
I
L
D
R
G
A
H
K
A
T
E
F
A
G
L
M
E
A
M
S
E
A
A
D
N
Y
E
P
A
A
F
L
R
F
V
M
E
T
S
G
Y
L
D
L
L
--
R
Q
E
G
---
Q
E
G
Q
V
R
L
E
N
L
E
E
L
V
S
A
A
E
E
W
S
Q
D
E
A
-----
N
V
G
-
G
S
-
I
A
D
F
-
L
D
D
A
A
L
L
S
S
V
D
D
M
R
T
K
A
E
-
N
---
K
G
A
P
E
D
A
---
V
T
L
M
T
L
H
N
A
K
G
L
E
F
P
V
V
F
I
V
G
V
E
Q
G
L
L
P
S
K
G
A
-
I
-----------------------------------
A
E
G
P
S
G
I
E
E
E
R
R
L
F
Y
V
G
I
T
R
A
M
E
R
L
L
M
T
A
A
Q
N
R
M
Q
F
G
K
T
N
A
A
E
D
S
A
F
L
E
D
I
E
G
L
F
D
T
----------------------------------------------------------------------------------------------------------------------------
21
PsiBlast_CBE
77.33
59%
-3
- C4 -
-
2PJR
2
?
F:
[8-545]
---
L
L
A
H
L
N
K
E
Q
Q
E
A
V
R
T
T
E
G
P
L
L
I
M
A
G
A
G
S
G
K
T
R
V
L
T
H
R
I
A
Y
L
M
A
E
K
--
H
V
A
P
W
N
I
L
A
I
T
F
T
N
K
A
A
R
E
M
R
E
R
V
Q
S
L
L-
G
G
--
A
----------------
A
E
D
V
W
-
I
S
T
F
H
S
M
C
V
R
I
L
R
R
D
I
D
R
I
G
I
N
--
R
N
F
S
I
L
D
P
T
D
Q
L
S
V
M
K
T
I
L
K
E
K
N
I
D
P
-----------------------------------------
K
K
F
E
P
R
T
I
L
-------------------------
G
T
I
S
A
-------------------------------
A
----------------------------
K
N
E
L
--
L
P
P
E
Q
F
------
A
K
R
--------
A
---------------
S
------
T
Y
Y
E
K
V
V
S
D
V
Y
Q
E
Y
Q
Q
R
L
L
R
N
H
S
L
D
F
D
D
L
I
M
T
T
I
Q
L
F
D
R
V
--------
P
D
V
L
H
Y
Y
Q
Y
K
F
Q
Y
I
H
I
D
E
Y
Q
D
T
N
R
A
Q
Y
T
L
V
K
K
L
A
E
R
---
F
Q
N
I
C
A
V
G
D
A
D
Q
S
I
Y
R
W
R
G
A
D
I
Q
N
I
L
S
F
E
R
D
Y
P
-----
N
A
K
V
I
L
L
E
Q
N
Y
R
S
T
K
R
I
L
Q
A
A
N
E
V
I
E
H
N
V
N
R
K
P
K
R
--------
I
W
--
T
E
--
N
P
E
G
K
P
-------
I
L
Y
Y
E
A
M
N
E
A
D
E
A
Q
F
V
A
G
R
I
R
E
A
V
E
R
------------
G
E
R
R
----
Y
R
D
F
A
V
L
Y
R
T
N
A
Q
S
R
V
M
E
E
M
L
L
K
A
N
I
P
Y
Q
I
V
G
G
L
K
F
Y
D
R
K
E
I
K
D
I
L
A
Y
L
R
V
I
A
N
P
D
D
D
L
S
L
L
R
I
I
N
V
P
K
R
G
I
G
A
S
T
I
D
K
L
V
R
Y
A
A
D
H
E
L
S
L
F
E
A
L
G
E
L
E
-
M
-
I
-
G
L
G
A
K
A
A
G
A
L
A
A
F
R
S
Q
L
E
Q
W
T
Q
L
Q
E
Y
V
S
V
T
E
L
V
E
E
V
L
D
K
S
G
Y
R
E
M
L
--
K
A
E
R
--
T
I
E
A
Q
S
R
L
E
N
L
D
E
F
L
S
V
T
K
H
F
E
N
V
S
D
---------
D
K
S
L
I
A
F
-
L
T
D
L
A
L
I
S
D
L
D
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
77.29
59%
-4
- C4 -
-
2PJR
1
?
A:
[8-545]
---
L
L
A
H
L
N
K
E
Q
Q
E
A
V
R
T
T
E
G
P
L
L
I
M
A
G
A
G
S
G
K
T
R
V
L
T
H
R
I
A
Y
L
M
A
E
K
--
H
V
A
P
W
N
I
L
A
I
T
F
T
N
K
A
A
R
E
M
R
E
R
V
Q
S
L
L-
G
G
--
A
----------------
A
E
D
V
W
-
I
S
T
F
H
S
M
C
V
R
I
L
R
R
D
I
D
R
I
G
I
N
--
R
N
F
S
I
L
D
P
T
D
Q
L
S
V
M
K
T
I
L
K
E
K
N
I
D
P
-----------------------------------------
K
K
F
E
P
R
T
I
L
-------------------------
G
T
I
S
A
-------------------------------
A
----------------------------
K
N
E
L
--
L
P
P
E
Q
F
------
A
K
R
--------
A
---------------
S
------
T
Y
Y
E
K
V
V
S
D
V
Y
Q
E
Y
Q
Q
R
L
L
R
N
H
S
L
D
F
D
D
L
I
M
T
T
I
Q
L
F
D
R
V
--------
P
D
V
L
H
Y
Y
Q
Y
K
F
Q
Y
I
H
I
D
E
Y
Q
D
T
N
R
A
Q
Y
T
L
V
K
K
L
A
E
R
---
F
Q
N
I
C
A
V
G
D
A
D
Q
S
I
Y
R
W
R
G
A
D
I
Q
N
I
L
S
F
E
R
D
Y
P
-----
N
A
K
V
I
L
L
E
Q
N
Y
R
S
T
K
R
I
L
Q
A
A
N
E
V
I
E
H
N
V
N
R
K
P
K
R
--------
I
W
--
T
E
--
N
P
E
G
K
P
-------
I
L
Y
Y
E
A
M
N
E
A
D
E
A
Q
F
V
A
G
R
I
R
E
A
V
E
R
------------
G
E
R
R
----
Y
R
D
F
A
V
L
Y
R
T
N
A
Q
S
R
V
M
E
E
M
L
L
K
A
N
I
P
Y
Q
I
V
G
G
L
K
F
Y
D
R
K
E
I
K
D
I
L
A
Y
L
R
V
I
A
N
P
D
D
D
L
S
L
L
R
I
I
N
V
P
K
R
G
I
G
A
S
T
I
D
K
L
V
R
Y
A
A
D
H
E
L
S
L
F
E
A
L
G
E
L
E
-
M
-
I
-
G
L
G
A
K
A
A
G
A
L
A
A
F
R
S
Q
L
E
Q
W
T
Q
L
Q
E
Y
V
S
V
T
E
L
V
E
E
V
L
D
K
S
G
Y
R
E
M
L
--
K
A
E
R
--
T
I
E
A
Q
S
R
L
E
N
L
D
E
F
L
S
V
T
K
H
F
E
N
V
S
D
---------
D
K
S
L
I
A
F
-
L
T
D
L
A
L
I
S
D
L
D
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
77.03
40%
-5
- C4 -
-
2IS2
2
UVRD_ECOLI
A:
[6-642]
---
L
L
D
S
L
N
D
K
Q
R
E
A
V
A
A
P
R
S
N
L
L
V
L
A
G
A
G
S
G
K
T
R
V
L
V
H
R
I
A
W
L
M
S
V
E
--
N
C
S
P
Y
S
I
M
A
V
T
F
T
N
K
A
A
A
E
M
R
H
R
I
G
Q
L
--
M
G
--
T
----------------
S
Q
G
G
M
W
V
G
T
F
H
G
L
A
H
R
L
L
R
--
A
H
H
M
D
A
N
LP
Q
D
F
Q
I
L
D
S
E
D
Q
L
R
L
L
K
R
L
I
K
A
M
N
L
D
E
-----------------------------------------
K
Q
W
P
P
R
Q
A
M
-------------------------
W
Y
I
N
S
-------------------------------
Q
----------------------------
K
D
E
G
--
L
R
P
-
H
H
------
I
Q
S
--------
Y
---------------
G
------
N
P
V
E
Q
T
W
Q
K
V
Y
Q
A
Y
Q
E
A
C
D
R
A
G
L
V
D
F
A
E
L
L
L
R
A
H
E
L
W
L
N
K
--------
P
H
I
L
Q
H
Y
R
E
R
F
T
N
I
L
V
D
E
F
Q
D
T
N
N
I
Q
Y
A
W
I
R
L
L
A
G
D
---
T
G
K
V
M
I
V
G
D
D
D
Q
S
I
Y
G
W
R
G
A
Q
V
E
N
I
Q
R
F
L
N
D
F
P
-----
G
A
E
T
I
R
L
E
Q
N
Y
R
S
T
S
N
I
L
S
A
A
N
A
L
I
E
N
N
N
G
R
L
G
K
K
--------
L
W
--
T
D
--
G
A
D
G
E
P
-------
I
S
L
Y
C
A
F
N
E
L
D
E
A
R
F
V
V
N
R
I
K
T
W
Q
D
N
------------
G
G
A
L
-----
A
E
C
A
I
L
Y
R
S
N
A
Q
S
R
V
L
E
E
A
L
L
Q
A
S
M
P
Y
R
I
Y
G
G
M
R
F
F
E
R
Q
E
I
K
D
A
L
S
Y
L
R
L
I
V
N
R
N
D
D
A
A
F
E
R
V
V
N
T
P
T
R
G
I
G
D
R
T
L
D
V
V
R
Q
T
S
R
D
R
Q
L
T
L
W
Q
A
C
R
E
L
L
-
Q
E
K
-
A
L
A
G
R
A
A
S
A
L
Q
R
F
M
E
L
I
D
A
L
A
Q
E
T
A
D
M
P
L
H
V
Q
T
D
R
V
I
K
D
S
G
L
R
T
M
Y
--
E
Q
E
K
--
G
E
K
G
Q
T
R
I
E
N
L
E
E
L
V
T
A
T
R
Q
F
----
S
Y
---
D
E
D
L
-
M
P
-
L
Q
A
F
-
L
S
H
A
A
L
E
A
G
E
G
--------
Q
---
A
D
T
W
Q
D
A
---
V
Q
L
M
T
L
H
S
A
K
G
L
E
F
P
Q
V
F
I
V
G
M
E
E
G
M
F
P
S
Q
M
S
-
L
-----------------------------------
D
-
E
G
G
R
L
E
E
E
R
R
L
A
Y
V
G
V
T
R
A
M
Q
K
L
T
L
T
Y
A
E
T
R
R
L
Y
G
K
E
V
Y
H
R
P
S
R
F
I
G
E
L
P
E
E
C
V
E
----------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
76.16
40%
1
- C4 -
-
2IS1
4
UVRD_ECOLI
A:
[6-642]
---
L
L
D
S
L
N
D
K
Q
R
E
A
V
A
A
P
R
S
N
L
L
V
L
A
G
A
G
S
G
K
T
R
V
L
V
H
R
I
A
W
L
M
S
V
E
--
N
C
S
P
Y
S
I
M
A
V
T
F
T
N
K
A
A
A
E
M
R
H
R
I
G
Q
L
--
M
G
--
T
----------------
S
Q
G
G
M
W
V
G
T
F
H
G
L
A
H
R
L
L
R
--
A
H
H
M
D
A
N
LP
Q
D
F
Q
I
L
D
S
E
D
Q
L
R
L
L
K
R
L
I
K
A
M
N
L
D
E
-----------------------------------------
K
Q
W
P
P
R
Q
A
M
-------------------------
W
Y
I
N
S
-------------------------------
Q
----------------------------
K
D
E
G
--
L
R
P
-
H
H
------
I
Q
S
--------
Y
---------------
G
------
N
P
V
E
Q
T
W
Q
K
V
Y
Q
A
Y
Q
E
A
C
D
R
A
G
L
V
D
F
A
E
L
L
L
R
A
H
E
L
W
L
N
K
--------
P
H
I
L
Q
H
Y
R
E
R
F
T
N
I
L
V
D
E
F
Q
D
T
N
N
I
Q
Y
A
W
I
R
L
L
A
G
D
---
T
G
K
V
M
I
V
G
D
D
D
Q
S
I
Y
G
W
R
G
A
Q
V
E
N
I
Q
R
F
L
N
D
F
P
-----
G
A
E
T
I
R
L
E
Q
N
Y
R
S
T
S
N
I
L
S
A
A
N
A
L
I
E
N
N
N
G
R
L
G
K
K
--------
L
W
--
T
D
--
G
A
D
G
E
P
-------
I
S
L
Y
C
A
F
N
E
L
D
E
A
R
F
V
V
N
R
I
K
T
W
Q
D
N
------------
G
G
A
L
-----
A
E
C
A
I
L
Y
R
S
N
A
Q
S
R
V
L
E
E
A
L
L
Q
A
S
M
P
Y
R
I
Y
G
G
M
R
F
F
E
R
Q
E
I
K
D
A
L
S
Y
L
R
L
I
V
N
R
N
D
D
A
A
F
E
R
V
V
N
T
P
T
R
G
I
G
D
R
T
L
D
V
V
R
Q
T
S
R
D
R
Q
L
T
L
W
Q
A
C
R
E
L
L
-
Q
E
K
-
A
L
A
G
R
A
A
S
A
L
Q
R
F
M
E
L
I
D
A
L
A
Q
E
T
A
D
M
P
L
H
V
Q
T
D
R
V
I
K
D
S
G
L
R
T
M
Y
--
E
Q
E
K
--
G
E
K
G
Q
T
R
I
E
N
L
E
E
L
V
T
A
T
R
Q
F
----
S
Y
N
---
E
D
L
-
M
P
-
L
Q
A
F
-
L
S
H
A
A
L
E
A
G
E
G
--------
Q
---
A
D
T
W
Q
D
A
---
V
Q
L
M
T
L
H
S
A
K
G
L
E
F
P
Q
V
F
I
V
G
M
E
E
G
M
F
P
S
Q
M
S
-
L
-----------------------------------
D
-
E
G
G
R
L
E
E
E
R
R
L
A
Y
V
G
V
T
R
A
M
Q
K
L
T
L
T
Y
A
E
T
R
R
L
Y
G
K
E
V
Y
H
R
P
S
R
F
I
G
E
L
P
E
E
C
V
E
----------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
76.13
43%
21
- C4 -
-
4C30
1
?
A:
[9-648]
---
L
L
Q
A
L
N
P
T
Q
A
Q
A
A
D
H
F
T
G
P
A
L
V
I
A
G
A
G
S
G
K
T
R
T
L
I
Y
R
I
A
H
L
I
G
H
Y
--
G
V
H
P
G
E
I
L
A
V
T
F
T
N
K
A
A
A
E
M
R
E
R
A
G
H
L
--
V
P
--
G
----------------
A
G
D
L
W
-
M
S
T
F
H
S
A
G
V
R
I
L
R
T
Y
G
E
H
I
G
L
R
--
R
G
F
V
I
Y
D
D
D
D
Q
L
D
I
I
K
E
V
M
G
S
I
P
G
I
G
-----------------------------------------
A
E
T
Q
P
R
V
I
R
-------------------------
G
I
I
D
R
-------------------------------
A
----------------------------
K
S
N
L
WT
P
D
D
L
D
R
------
S
R
E
--------
P
------------------------
P
R
D
A
A
A
E
A
Y
R
R
Y
E
V
R
K
K
G
Q
N
A
I
D
F
G
D
L
I
T
E
T
V
R
L
F
K
E
V
--------
P
G
V
L
D
K
V
Q
N
K
A
K
F
I
H
V
D
E
Y
Q
D
T
N
R
A
Q
Y
E
L
T
R
L
L
A
S
R
---
D
R
N
L
L
V
V
G
D
P
D
Q
S
I
Y
K
F
R
G
A
D
I
Q
N
I
L
D
F
Q
K
D
Y
P
-----
D
A
K
V
Y
M
L
E
H
N
Y
R
S
S
A
R
V
L
E
A
A
N
K
L
I
E
N
N
T
E
R
L
D
K
T
--------
L
K
--
P
V
--
K
E
A
G
Q
P
-------
V
T
F
H
R
A
T
D
H
R
A
E
G
D
Y
V
A
D
W
L
T
R
L
-
H
G
------------
E
G
R
A
----
W
S
E
M
A
I
L
Y
R
T
N
A
Q
S
R
V
I
E
E
S
L
R
R
V
Q
I
P
A
R
I
V
G
G
V
G
F
Y
D
R
R
E
I
R
D
I
L
A
Y
A
R
L
A
L
N
P
A
D
D
V
A
L
R
R
I
I
G
R
P
R
R
G
I
G
D
T
A
L
Q
K
L
M
E
W
A
R
T
H
H
T
S
V
L
T
A
C
A
N
-------------
A
H
K
A
T
E
F
A
G
L
M
E
A
M
S
E
A
A
D
N
Y
E
P
A
A
F
L
R
F
V
M
E
T
S
G
Y
L
D
L
L
--
R
-
Q
E
--
G
Q
E
G
Q
V
R
L
E
N
L
E
E
L
V
S
A
A
E
E
W
------
S
Q
D
E
A
------
I
A
D
F
-
L
D
D
A
A
L
L
S
S
V
D
DMRTKAE-------
P
E
D
A
----
V
T
L
M
T
L
H
N
A
K
G
L
E
F
P
V
V
F
I
V
G
V
E
Q
G
L
L
P
S
K
G
A
I
A
-----------------------------------
E
-
G
P
S
G
I
E
E
E
R
R
L
F
Y
V
G
I
T
R
A
M
E
R
L
L
M
T
A
A
Q
N
R
M
Q
F
G
K
T
N
A
A
E
D
S
A
F
L
E
D
I
----------------------------------------------------------------------------------------------------------------------------------
25
PsiBlast_CBE
75.73
43%
22
- C4 -
-
4C30
1
?
F:
[9-648]
---
L
L
Q
A
L
N
P
T
Q
A
Q
A
A
D
H
F
T
G
P
A
L
V
I
A
G
A
G
S
G
K
T
R
T
L
I
Y
R
I
A
H
L
I
G
H
Y
--
G
V
H
P
G
E
I
L
A
V
T
F
T
N
K
A
A
A
E
M
R
E
R
A
G
H
L
--
V
P
--
G
----------------
A
G
D
L
W
-
M
S
T
F
H
S
A
G
V
R
I
L
R
T
Y
G
E
H
I
G
L
R
--
R
G
F
V
I
Y
D
D
D
D
Q
L
D
I
I
K
E
V
M
G
S
I
P
G
I
G
-----------------------------------------
A
E
T
Q
P
R
V
I
R
-------------------------
G
I
I
D
R
-------------------------------
A
----------------------------
K
S
N
L
WT
P
D
D
L
D
R
------
S
R
E
--------
P
------------------------
P
R
D
A
A
A
E
A
Y
R
R
Y
E
V
R
K
K
G
Q
N
A
I
D
F
G
D
L
I
T
E
T
V
R
L
F
K
E
V
--------
P
G
V
L
D
K
V
Q
N
K
A
K
F
I
H
V
D
E
Y
Q
D
T
N
R
A
Q
Y
E
L
T
R
L
L
A
S
R
---
D
R
N
L
L
V
V
G
D
P
D
Q
S
I
Y
K
F
R
G
A
D
I
Q
N
I
L
D
F
Q
K
D
Y
P
-----
D
A
K
V
Y
M
L
E
H
N
Y
R
S
S
A
R
V
L
E
A
A
N
K
L
I
E
N
N
T
E
R
L
D
K
T
--------
L
K
--
P
V
--
K
E
A
G
Q
P
-------
V
T
F
H
R
A
T
D
H
R
A
E
G
D
Y
V
A
D
W
L
T
R
L
-
H
G
------------
E
G
R
A
----
W
S
E
M
A
I
L
Y
R
T
N
A
Q
S
R
V
I
E
E
S
L
R
R
V
Q
I
P
A
R
I
V
G
G
V
G
F
Y
D
R
R
E
I
R
D
I
L
A
Y
A
R
L
A
L
N
P
A
D
D
V
A
L
R
R
I
I
G
R
P
R
R
G
I
G
D
T
A
L
Q
K
L
M
E
W
A
R
T
H
H
T
S
V
L
T
A
C
A
N
-------------
A
H
K
A
T
E
F
A
G
L
M
E
A
M
S
E
A
A
D
N
Y
E
P
A
A
F
L
R
F
V
M
E
T
S
G
Y
L
D
L
L
--
R
-
Q
E
--
G
Q
E
G
Q
V
R
L
E
N
L
E
E
L
V
S
A
A
E
E
W
------
S
Q
D
E
A
------
I
A
D
F
-
L
D
D
A
A
L
L
S
S
V
D
DMRTKAE-------
P
E
D
A
----
V
T
L
M
T
L
H
N
A
K
G
L
E
F
P
V
V
F
I
V
G
V
E
Q
G
L
L
P
S
K
G
A
I
A
-----------------------------------
E
-
G
P
S
G
I
E
E
E
R
R
L
F
Y
V
G
I
T
R
A
M
E
R
L
L
M
T
A
A
Q
N
R
M
Q
F
G
K
T
N
A
A
E
D
S
A
F
L
E
D
I
----------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
75.25
40%
6
- C4 -
-
2IS6
5
UVRD_ECOLI
A:
[6-642]
---
L
L
D
S
L
N
D
K
Q
R
E
A
V
A
A
P
R
S
N
L
L
V
L
A
G
A
G
S
G
K
T
R
V
L
V
H
R
I
A
W
L
M
S
V
E
--
N
C
S
P
Y
S
I
M
A
V
T
F
T
N
K
A
A
A
E
M
R
H
R
I
G
Q
L
--
M
G
--
T
----------------
S
Q
G
G
M
W
V
G
T
F
H
G
L
A
H
R
L
L
R
--
A
H
H
M
D
A
N
LP
Q
D
F
Q
I
L
D
S
E
D
Q
L
R
L
L
K
R
L
I
K
A
M
N
L
D
E
-----------------------------------------
K
Q
W
P
P
R
Q
A
M
-------------------------
W
Y
I
N
S
-------------------------------
Q
----------------------------
K
D
E
G
--
L
R
P
-
H
H
------
I
Q
S
--------
Y
---------------
G
------
N
P
V
E
Q
T
W
Q
K
V
Y
Q
A
Y
Q
E
A
C
D
R
A
G
L
V
D
F
A
E
L
L
L
R
A
H
E
L
W
L
N
K
--------
P
H
I
L
Q
H
Y
R
E
R
F
T
N
I
L
V
D
E
F
Q
D
T
N
N
I
Q
Y
A
W
I
R
L
L
A
G
D
---
T
G
K
V
M
I
V
G
D
D
D
Q
S
I
Y
G
W
R
G
A
Q
V
E
N
I
Q
R
F
L
N
D
F
P
-----
G
A
E
T
I
R
L
E
Q
N
Y
R
S
T
S
N
I
L
S
A
A
N
A
L
I
E
N
N
N
G
R
L
G
K
K
--------
L
W
--
T
D
--
G
A
D
G
E
P
-------
I
S
L
Y
C
A
F
N
E
L
D
E
A
R
F
V
V
N
R
I
K
T
W
Q
D
N
------------
G
G
A
L
-----
A
E
C
A
I
L
Y
R
S
N
A
Q
S
R
V
L
E
E
A
L
L
Q
A
S
M
P
Y
R
I
Y
G
G
M
R
F
F
E
R
Q
E
I
K
D
A
L
S
Y
L
R
L
I
V
N
R
N
D
D
A
A
F
E
R
V
V
N
T
P
T
R
G
I
G
D
R
T
L
D
V
V
R
Q
T
S
R
D
R
Q
L
T
L
W
Q
A
C
R
E
L
L
-
Q
E
K
-
A
L
A
G
R
A
A
S
A
L
Q
R
F
M
E
L
I
D
A
L
A
Q
E
T
A
D
M
P
L
H
V
Q
T
D
R
V
I
K
D
S
G
L
R
T
M
Y
--
E
Q
E
K
--
G
E
K
G
Q
T
R
I
E
N
L
E
E
L
V
T
A
T
R
Q
F
----
S
Y
N
E
E
D
--
L
-
M
P
-
L
Q
A
F
-
L
S
H
A
A
L
E
A
G
E
G
--------
Q
---
A
D
T
W
Q
D
A
---
V
Q
L
M
T
L
H
S
A
K
G
L
E
F
P
Q
V
F
I
V
G
M
E
E
G
M
F
P
S
Q
M
S
-
L
-----------------------------------
D
-
E
G
G
R
L
E
E
E
R
R
L
A
Y
V
G
V
T
R
A
M
Q
K
L
T
L
T
Y
A
E
T
R
R
L
Y
G
K
E
V
Y
H
R
P
S
R
F
I
G
E
L
P
E
E
C
V
E
----------------------------------------------------------------------------------------------------------------------------
23
PsiBlast_CBE
74.92
40%
0
- C4 -
-
2IS1
4
UVRD_ECOLI
B:
[6-642]
---
L
L
D
S
L
N
D
K
Q
R
E
A
V
A
A
P
R
S
N
L
L
V
L
A
G
A
G
S
G
K
T
R
V
L
V
H
R
I
A
W
L
M
S
V
E
--
N
C
S
P
Y
S
I
M
A
V
T
F
T
N
K
A
A
A
E
M
R
H
R
I
G
Q
L
--
M
G
--
T
----------------
S
Q
G
G
M
W
V
G
T
F
H
G
L
A
H
R
L
L
R
--
A
H
H
M
D
A
N
LP
Q
D
F
Q
I
L
D
S
E
D
Q
L
R
L
L
K
R
L
I
K
A
M
N
L
D
E
-----------------------------------------
K
Q
W
P
P
R
Q
A
M
-------------------------
W
Y
I
N
S
-------------------------------
Q
----------------------------
K
D
E
G
--
L
R
P
-
H
H
------
I
Q
S
---------------------------------
V
E
Q
T
W
Q
K
V
Y
Q
A
Y
Q
E
A
C
D
R
A
G
L
V
D
F
A
E
L
L
L
R
A
H
E
L
W
L
N
K
--------
P
H
I
L
Q
H
Y
R
E
R
F
T
N
I
L
V
D
E
F
Q
D
T
N
N
I
Q
Y
A
W
I
R
L
L
A
G
D
---
T
G
K
V
M
I
V
G
D
D
D
Q
S
I
Y
G
W
R
G
A
Q
V
E
N
I
Q
R
F
L
N
D
F
P
-----
G
A
E
T
I
R
L
E
Q
N
Y
R
S
T
S
N
I
L
S
A
A
N
A
L
I
E
N
N
N
G
R
L
G
K
K
--------
L
W
--
T
D
--
G
A
D
G
E
P
-------
I
S
L
Y
C
A
F
N
E
L
D
E
A
R
F
V
V
N
R
I
K
T
W
Q
D
N
------------
G
G
A
L
-----
A
E
C
A
I
L
Y
R
S
N
A
Q
S
R
V
L
E
E
A
L
L
Q
A
S
M
P
Y
R
I
Y
G
G
M
R
F
F
E
R
Q
E
I
K
D
A
L
S
Y
L
R
L
I
V
N
R
N
D
D
A
A
F
E
R
V
V
N
T
P
T
R
G
I
G
D
R
T
L
D
V
V
R
Q
T
S
R
D
R
Q
L
T
L
W
Q
A
C
R
E
L
L
-
Q
E
K
-
A
L
A
G
R
A
A
S
A
L
Q
R
F
M
E
L
I
D
A
L
A
Q
E
T
A
D
M
P
L
H
V
Q
T
D
R
V
I
K
D
S
G
L
R
T
M
Y
--
E
Q
E
K
--
G
E
K
G
Q
T
R
I
E
N
L
E
E
L
V
T
A
T
R
Q
F
----
S
Y
---
D
E
D
L
-
M
P
-
L
Q
A
F
-
L
S
H
A
A
L
E
A
G
E
G
----------------
Q
D
A
---
V
Q
L
M
T
L
H
S
A
K
G
L
E
F
P
Q
V
F
I
V
G
M
E
E
G
M
F
P
S
Q
M
-------------------------------------------
R
L
E
E
E
R
R
L
A
Y
V
G
V
T
R
A
M
Q
K
L
T
L
T
Y
A
E
T
R
R
L
Y
G
K
E
V
Y
H
R
P
S
R
F
I
G
E
L
P
E
E
C
V
E
----------------------------------------------------------------------------------------------------------------------------
44
HHSearch
69.10
38%
24
* C4 *
-
1UAA
1
REP_ECOLI
A:
[2-640]
------
R
L
N
P
G
Q
Q
Q
A
V
E
F
V
T
G
P
C
L
V
L
A
G
A
G
S
G
K
T
R
V
I
T
N
K
I
A
H
L
I
R
G
C
--
G
Y
Q
A
R
H
I
A
A
V
T
F
T
N
K
A
A
R
E
M
K
E
R
V
G
Q
T
--
L
G
RK
E
----------------
A
R
G
L
M
-
I
S
T
F
H
T
L
G
L
D
I
I
K
R
E
Y
A
A
L
G
M
K
--
A
N
F
S
L
F
D
D
T
D
Q
L
A
L
L
K
E
L
T
E
G
L
I
E
D
D
-----------------------------------------
K
V
L
-
L
Q
Q
L
I
-------------------------
S
T
I
S
N
-------------------------------
W
----------------------------
K
N
D
L
--
K
T
P
S
Q
A
------
A
A
S
--------
A
---------------
I
------
G
E
R
D
R
I
F
A
H
C
Y
G
L
Y
D
A
H
L
K
A
C
N
V
L
D
F
D
D
L
I
L
L
P
T
L
L
L
Q
A
N
--------
E
E
V
R
K
R
W
Q
N
K
I
R
Y
L
L
V
D
E
Y
Q
D
T
N
T
S
Q
Y
E
L
V
K
L
L
V
G
S
---
R
A
R
F
T
V
V
G
D
D
D
Q
S
I
Y
S
W
R
G
A
R
P
Q
N
L
V
L
L
S
Q
D
F
P
-----
A
L
K
V
I
K
L
E
Q
N
Y
R
S
S
G
R
I
L
K
A
A
N
I
L
I
A
N
N
P
H
V
F
E
K
R
--------
L
F
--
S
E
--
L
G
Y
G
A
E
-------
L
K
V
L
S
A
N
N
E
E
H
E
A
E
R
V
T
G
E
L
I
A
H
H
F
V
------------
N
K
T
Q
----
Y
K
D
Y
A
I
L
Y
R
G
N
H
Q
S
R
V
F
E
K
F
L
M
Q
N
R
I
P
Y
K
I
S
G
G
T
S
F
F
S
R
P
E
I
K
D
L
L
A
Y
L
R
V
L
T
N
P
D
D
D
S
A
F
L
R
I
V
N
T
P
K
R
E
I
G
P
A
T
L
K
K
L
G
E
W
A
M
T
R
N
K
S
M
F
T
A
S
F
D
M
G
-
L
S
Q
-
T
L
S
G
R
G
Y
E
A
L
T
R
F
T
H
W
L
A
E
I
Q
R
L
-
A
E
R
E
P
I
A
A
V
R
D
L
I
H
G
M
D
Y
E
S
W
L
--
Y
E
T
S
PS
P
K
A
A
E
M
R
M
K
N
V
N
Q
L
F
S
W
M
T
E
M
L
E
G
S
E
----
L
D
E
P
-
M
T
-
L
T
Q
V
-
V
T
R
F
T
L
R
D
M
M
E
--------
R
----
E
E
E
L
D
Q
---
V
Q
L
M
T
L
H
A
S
K
G
L
E
F
P
Y
V
Y
M
V
G
M
E
E
G
F
L
P
H
Q
S
S
-
I
-----------------------------------
D
--
E
D
N
I
D
E
E
R
R
L
A
Y
V
G
I
T
R
A
Q
K
E
L
T
F
T
L
C
K
E
R
R
Q
Y
G
E
L
V
R
P
E
P
S
R
F
L
L
E
L
P
Q
D
D
L
I
-----
W
----------------------------------------------------------------------------------------------------------------------
47
HHSearch
68.37
26%
15
- C4 -
-
3U4Q
-
ADDA_BACSU
A:
[10-951]
------
T
W
T
D
D
Q
W
N
A
I
V
S
T
G
Q
D
I
L
V
A
A
A
A
G
S
G
K
T
A
V
L
V
E
R
M
I
R
K
I
T
A
E
E
N
P
I
D
V
D
R
L
L
V
V
T
F
T
N
A
S
A
A
E
M
K
H
R
I
A
E
A
--
L
E
K
-
E
L
V
Q
R
PGS
L
H
I
R
R
Q
L
S
L
L
N
R
A
S
-
I
S
T
L
H
S
F
C
L
Q
V
L
K
K
Y
Y
Y
L
I
D
L
D
--
P
G
F
R
I
A
D
Q
T
E
G
E
L
I
G
D
E
V
L
D
E
L
F
E
D
E
Y
A
K
GE
K
A
F
F
E
L
V
D
R
YTTDRHD
L
D
L
Q
F
L
V
K
Q
V
Y
E
Y
S
R
S
HPN
P
E
A
W
-
L
E
S
F
V
HLYDVSEKSAIEELPFY
Q
Y
V
K
E
D
I
A
M
V
L
N
G
A
K
E
K
L
L
R
A
L
E
L
TD
N
F
L
D
D
L
A
Q
----------
I
D
E
L
I
Q
H
Q
DD
F
S
E
L
Y
K
R
VPAVS--------------
D
P
A
L
L
D
E
A
T
D
L
R
N
G
A
K
K
L
L
E
K
L
K
T
D
YFTRS
P
E
Q
H
L
K
S
L
A
E
M
K
P
V
I
E
T
L
V
Q
L
V
I
S
Y
G
K
R
F
E
A
A
K
Q
E
K
S
I
I
D
F
S
D
L
E
H
Y
C
L
A
I
L
T
A
E
NDREP---
S
E
A
A
R
F
Y
Q
E
Q
F
H
E
V
L
V
D
E
Y
Q
D
T
N
L
V
Q
E
S
I
L
Q
L
V
T
S
G
PEE
T
G
N
L
F
M
V
G
D
V
K
Q
S
I
Y
R
F
R
L
A
E
P
L
L
F
L
S
K
Y
K
R
F
T
ESGEG
T
G
R
K
I
D
L
N
K
N
F
R
S
R
A
D
I
L
D
S
T
N
F
L
F
K
Q
L
M
G
G
K
I
G
E
V
D
Y
D
E
QAE
L
K
LG
A
A
YP
D
N
D
E
T
E
T
E
L
L
L
I
D-----
L
E
T
V
Q
F
E
A
K
A
I
A
K
E
I
R
K
L
I
S
S
PFKVYK
K
T
H
---
R
N
I
Q
----
Y
R
D
I
V
I
L
L
R
S
M
P
W
A
P
Q
I
M
E
E
L
R
A
Q
G
I
P
V
Y
A
N
L
T
S
G
Y
F
E
A
V
E
V
A
V
A
L
S
V
L
K
V
I
D
N
P
Y
Q
D
I
P
L
A
S
V
L
R
S
P
I
V
G
A
D
E
N
E
L
S
L
I
R
L
E
N
--
K
K
A
P
Y
Y
E
A
M
K
D
Y
L
A
A
-
G
-
D
R
S
D
E
L
Y
Q
K
L
N
T
F
Y
G
H
L
Q
K
W
R
A
F
S
K
N
H
S
V
S
E
L
I
W
E
V
Y
R
D
T
K
Y
M
D
Y
V
--
G
G
M
----
P
G
G
K
Q
R
Q
A
N
L
R
V
L
Y
D
R
A
R
Q
Y
E
S
T
--------
A
F
-
R
G
-
L
F
R
F
-
L
R
F
I
E
R
M
Q
E
R
G
D--------------
Q
E
D
V
---
V
R
L
M
T
I
H
S
S
K
G
L
E
F
P
V
V
F
V
A
G
L
G
R
N
-
F
N
M
M
D
L
-
N
KS
Y
L
L
D
KEL
G
F
G
T
K
YIHPQLR
I
S
Y
P
T
L
P
L
I
A
M
K
K
K
M
-
R
R
E
L
L
S
E
E
L
R
V
L
Y
V
A
L
T
R
A
K
E
K
L
F
L
I
G
S
C
K
D
H
Q
-
K
Q
L
A
K
W
Q
A
S
A
S
Q
T
------------------------------------------------------------------------------------------------------------------------------------
48
HHSearch
68.30
26%
0
- C- -
-
4CEJ
1
ADDA_BACSU
A:
[10-935]
------
T
W
T
D
D
Q
W
N
A
I
V
S
T
G
Q
D
I
L
V
A
A
A
A
G
S
G
K
T
A
V
L
V
E
R
M
I
R
K
I
T
A
E
E
N
P
I
D
V
D
R
L
L
V
V
T
F
T
N
A
S
A
A
E
M
K
H
R
I
A
E
A
--
L
E
K
-
E
L
V
Q
R
PGS
L
H
I
R
R
Q
L
S
L
L
N
R
A
S
-
I
S
T
L
H
S
F
C
L
Q
V
L
K
K
Y
Y
Y
L
I
D
L
D
--
P
G
F
R
I
A
D
Q
T
E
G
E
L
I
G
D
E
V
L
D
E
L
F
E
D
E
Y
A
K
GE
K
A
F
F
E
L
V
D
R
YTTDRHD
L
D
L
Q
F
L
V
K
Q
V
Y
E
Y
S
R
S
HPN
P
E
A
W
-
L
E
S
F
V
HLYDVSEKSAIEELPFY
Q
Y
V
K
E
D
I
A
M
V
L
N
G
A
K
E
K
L
L
R
A
L
E
L
T
K
APGGPAPR
A
D
N
F
L
D
D
L
A
Q
I
D
E
L
I
Q
H
Q
DD
F
S
E
L
Y
K
R
V
PA
V
S
F
K
R
AK
A
V
K
G
D
E
--
F
D
P
A
L
L
D
E
A
T
D
L
R
N
G
A
K
K
L
L
E
K
L
K
T
D
YFTRS
P
E
Q
H
L
K
S
L
A
E
M
K
P
V
I
E
T
L
V
Q
L
V
I
S
Y
G
K
R
F
E
A
A
K
Q
E
K
S
I
I
D
F
S
D
L
E
H
Y
C
L
A
I
L
T
A
E
NDKG
E
R
E
P
S
E
A
A
R
F
Y
Q
E
Q
F
H
E
V
L
V
D
E
Y
Q
D
T
N
L
V
Q
E
S
I
L
Q
L
V
T
S
G
PEE
T
G
N
L
F
M
V
G
D
V
K
Q
S
I
Y
R
F
R
L
A
E
P
L
L
F
L
S
K
Y
K
R
F
T
ESGEG
T
G
R
K
I
D
L
N
K
N
F
R
S
R
A
D
I
L
D
S
T
N
F
L
F
K
Q
L
M
G
G
K
I
G
E
VDYDEQAE
L
K
LG
A
A
Y
P
D
N
D
E
T
E
T
E
L
L
L
I
D----
E
L
E
T
V
Q
F
E
A
K
A
I
A
K
E
I
R
K
L
I
S
S
P
F
K
V
Y
DGKKK
T
H
R
N
I
Q
----
Y
R
D
I
V
I
L
L
R
S
M
P
W
A
P
Q
I
M
E
E
L
R
A
Q
G
I
P
V
Y
A
N
L
T
S
G
Y
F
E
A
V
E
V
A
V
A
L
S
V
L
K
V
I
D
N
P
Y
Q
D
I
P
L
A
S
V
L
R
S
P
I
V
G
A
D
E
N
E
L
S
L
I
R
L
E
N
--
K
K
A
P
Y
Y
E
A
M
K
D
Y
L
A
A
-
G
-
D
R
S
D
E
L
Y
Q
K
L
N
T
F
Y
G
H
L
Q
K
W
R
A
F
S
K
N
H
S
V
S
E
L
I
W
E
V
Y
R
D
T
K
Y
M
D
Y
V
--
G
G
M
----
P
G
G
K
Q
R
Q
A
N
L
R
V
L
Y
D
R
A
R
Q
Y
E
S
T
--------
A
F
-
R
G
-
L
F
R
F
-
L
R
F
I
E
R
M
Q
E
R
G
D
D
L
G
----
T
A
RG
L
S
E
Q
E
D
V
---
V
R
L
M
T
I
H
S
S
K
G
L
E
F
P
V
V
F
V
A
G
L
G
R
N
-
F
N
M
M
D
L
-
N
KS
Y
L
L
D
KEL
G
F
G
T
K
YIHPQLR
I
S
Y
P
T
L
P
L
I
A
M
K
K
K
M
-
R
R
E
L
L
S
E
E
L
R
V
L
Y
V
A
L
T
R
A
K
E
K
L
F
L
I
G
S
C
K
D
H
Q
-
K
Q
L
A
K
W
Q
A
S
A
S
Q
T
------------------------------------------------------------------------------------------------------------------------------------
28
PsiBlast_CBE
67.74
38%
39
- C4 -
-
1UAA
1
REP_ECOLI
B:
[3-641]
-------
L
N
P
G
Q
Q
Q
A
V
E
F
V
T
G
P
C
L
V
L
A
G
A
G
S
G
K
T
R
V
I
T
N
K
I
A
H
L
I
R
G
C
--
G
Y
Q
A
R
H
I
A
A
V
T
F
T
N
K
A
A
R
E
M
K
E
R
V
G
Q
T
LG
R
K
--
E
----------------
A
R
G
L
M
-
I
S
T
F
H
T
L
G
L
D
I
I
K
R
E
Y
A
A
L
G
M
K
--
A
N
F
S
L
F
D
D
T
D
Q
L
A
L
L
K
E
L
T
E
G
L
I
E
D
D
-----------------------------------------
K
V
L
L
Q
Q
-
L
I
-------------------------
S
T
I
S
N
-------------------------------
W
----------------------------
K
N
D
L
--
K
T
P
S
Q
A
------
A
A
S
--------
A
---------------
I
------
G
E
R
D
R
I
F
A
H
C
Y
G
L
Y
D
A
H
L
K
A
C
N
V
L
D
F
D
D
L
I
L
L
P
T
L
L
L
Q
A
N
--------
E
E
V
R
K
R
W
Q
N
K
I
R
Y
L
L
V
D
E
Y
Q
D
T
N
T
S
Q
Y
E
L
V
K
L
L
V
G
S
---
R
A
R
F
T
V
V
G
D
D
D
Q
S
I
Y
S
W
R
G
A
R
P
Q
N
L
V
L
L
S
Q
D
F
P
-----
A
L
K
V
I
K
L
E
Q
N
Y
R
S
S
G
R
I
L
K
A
A
N
I
L
I
A
N
N
P
H
V
F
E
K
R
--------
L
F
--
S
E
--
L
G
Y
G
A
E
-------
L
K
V
L
S
A
N
N
E
E
H
E
A
---
E
R
V
T
G
E
L
I
-
A
------------
H
H
F
V
NKTQ
Y
K
D
Y
A
I
L
Y
R
G
N
H
Q
S
R
V
F
E
K
F
L
M
Q
N
R
I
P
Y
K
I
S
G
G
T
S
F
F
S
R
P
E
I
K
D
L
L
A
Y
L
R
V
L
T
N
P
D
D
D
S
A
F
L
R
I
V
N
T
P
K
R
E
I
G
P
A
T
L
K
K
L
G
E
W
A
M
T
R
N
K
S
M
F
T
A
S
F
D
M
G
-
L
-
S
Q
T
L
S
G
R
G
Y
E
A
L
T
R
F
T
H
W
L
A
E
I
Q
R
L
A
E
R
E
P
I
A
A
-
V
R
D
L
I
H
G
M
D
Y
E
S
W
L
YE
T
S
P
S
--
P
K
A
A
E
M
R
M
K
N
V
N
Q
L
F
S
W
M
T
E
M
L
E
G
S
E
L
D
E
P
M
T
L
T
-
Q
V
-
V
T
R
F
T
L
R
D
----------------------
E
E
L
D
Q
---
V
Q
L
M
T
L
H
A
S
K
G
L
E
F
P
Y
V
Y
M
V
G
M
E
E
G
F
L
P
-
H
Q
S
-
S
-----------------------------------
I
-
D
E
D
N
I
D
E
E
R
R
L
A
Y
V
G
I
T
R
A
Q
K
E
L
T
F
T
L
C
K
E
R
R
Q
Y
G
E
L
V
R
P
E
P
S
R
F
L
L
E
L
P
Q
D
D
L
I
-----
W
E
---------------------------------------------------------------------------------------------------------------------
32
PsiBlast_CBE
37.07
69%
-99
- C4 -
-
2PJR
1
?
B:
[4-92]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
M
L
M
T
L
H
A
A
K
G
L
E
F
P
V
V
F
L
I
G
M
E
E
G
I
F
P
H
N
R
S
-
L
-----------------------------------
E
-
D
D
D
E
M
E
E
E
R
R
L
A
Y
V
G
I
T
R
A
E
E
E
L
V
L
T
S
A
Q
M
R
T
L
F
G
N
I
Q
M
D
P
P
S
R
F
L
N
E
I
P
A
H
L
L
E
----------------------------------------------------------------------------------------------------------------------------
31
PsiBlast_CBE
36.95
69%
-97
- C4 -
-
2PJR
1
?
G:
[4-92]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
M
L
M
T
L
H
A
A
K
G
L
E
F
P
V
V
F
L
I
G
M
E
E
G
I
F
P
H
N
R
S
-
L
-----------------------------------
E
-
D
D
D
E
M
E
E
E
R
R
L
A
Y
V
G
I
T
R
A
E
E
E
L
V
L
T
S
A
Q
M
R
T
L
F
G
N
I
Q
M
D
P
P
S
R
F
L
N
E
I
P
A
H
L
L
E
----------------------------------------------------------------------------------------------------------------------------