@TOME V2.3
(Mar 2018)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : spr1025: (2018-01-03 )
MYNYPMRIHYHRKNGEYDTCSFVKSQDQRIDLLTYKEDYFGALFSFEHPSSHVIESLNFVVHTGQTSKEYSIRFNHYPLLTEVWILEGDDRIYYSENPAIASPFYKNQNPFAFDKAINSASFDHHWGYQGELGCRVEDNQAHFSLWSPTATEVQVVVYESAANDAPVWKTFEMKRGNSYSYNHKDNTIGVWSLDVEEDLVGKTYQYQVQFPHHQTLTRDPYTIATSPDGKRSAILSHVEKQVENFEVKHGSEATWRLENPCKAVICEMHIRDLTKSPTSGVDEHLRGTFLGAAQAGTVNQYGQSTAFDYIKKLGYNYVQLQPIADRHKEYDEDGNVTYNWGYDPQNYNAPETSFSTNPDDPAQVIRDLKVMVQAYHDAGIGVIMDVVYNHTFSVVDAPFQTTVPDYYYRMNPDGTFQNGTGVGNETASEHEMFRKYMIDSLLYWVQEYNIDGFRFDLMGIHDVKTMQMIRQSLDEIDSNIILYGEGWDMGTGLAPYDKAKKDNAYQMPNIGFFNDNQRDAVKGGEVYGAIKSGFVSGAATEPILAKAILGSRELGSYTHPNQVLNYVEAHDNYNLHDLLATLHPDQSSEQIMRKVETATAMNLLMQGMAFMEIGQEFGRTKLVATGENGELTHDDRERAMNSYNAPDSVNQVNWNLINERQDSIEFIRQVIRLKTKTGAFSYSSYDEIYHHVFVHSAIEHSGCLIYEVHGKEHLLVVVNAKSEPYQFENAGNLAMLVTNSRSKEDNVLNDISLAVLSVL
Atome Classification :
(20 SA)
.........10-------........20........-------------30........40........50........60........-70......--..80........90.......----.100---------------..-----.-----------------------.--.----------------.--------------------------------..-.110.......120......---.130.......--.--140.......150.......160....-...170.......180.......190.....-------.-----.200.....--..210-------------.------......220..----------.....----------230----------.------------......------------.--.240.....-.--.---250.......260.......270.......280-.......290.......300.......310.......320...---------....330..--------------------------------------------------------------.....340.......350......-----.360.......370.....-..380.......390...----...-----.400.......410-.......420.......430.......440.......450.......460..--------.....470....--------------------------------------.--------..480.......490--..--..--...500.......510.......520......-.-----530-.......-.-.----------------540-------------..----.----......550--------..-----------------------.----..----..----.560.......570.......580---..--------------------------.-----.---...590.......600.......610.......620....-...630---------.-------------------.......---------------.640.......650.....------.----------------------------------.------660.......670.......680.......690..------..-------.------.--.700.....-----..710-----------.-----------........720......------.-----730---.....---..------..740--------.-----------------------------.....--------------..--.750.......------
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MYNY
P
M
R
I
H
Y
H
-------RKNGEYD
T
C
S
F
V
KSQDQ
R
-------------
I
D
L
L
T
Y
K
E
D
Y
F
G
A
L
FSFEHP
S
S
H
V
I
E
S
L
N
F
V
V
HTGQTS
K
E
-
Y
S
I
R
FNHY--
P
L
L
T
E
V
W
I
L
EGD
D
R
I
Y
YSENP----AI-----------------AS-----P-----------------------F--Y----------------K--------------------------------NQ-NPF
A
F
D
K
AINSASFDHHWGY---QG-ELG
C
R
VED--N--Q
A
H
F
S
LWSPTA
T
E
V
Q
V
V
V
Y
ESAANDAP-V
W
K
T
F
E
MKRGNSYSYNHKDN
T
I
G
V
W
S
LDV
E
E
-------
D
-----LVG
K
T
Y
Q
Y
Q
--
V
QFPH-------------H------QTLTRDP
Y
T
I
A----------TSPD
G
----------
K
------------
R
------------
S
A
I
L
S
H
------------
V
--
E
K
Q
V
E
N
F
E
V-K--H---GSE
A
T
W
RLEN
P
C
K
A
V
I
C
E
M
H
I
R
D
LTKSPTS
G
V
D
-
E
H
L
R
G
TFLGAAQAG
T
V
N
QYG
Q
S
T
A
F
D
Y
I
K
K
LGY
N
Y
V
Q
L
Q
P
I
A
D
---------
R
H
K
E
YDEDG--------------------------------------------------------------
N
V
T
Y
NWGYDPQNYNAPETSFSTNP-----D
D
P
A
Q
V
I
R
D
L
K
V
M
V
Q
A
Y
HD-A
G
I
G
V
I
M
D
V
V
Y
NHTFSVV----DAP-----FQTTVPD
Y
Y
Y
R
MNP-DGTFQNGTGVGNET
A
S
E
H
E
M
F
R
K
Y
M
I
D
S
L
L
Y
W
V
Q
EYNID
G
F
R
F
D
LMGIH
D
V
K
--------
T
M
Q
M
I
R
Q
S
L
D
EI--------------------------------------D--------S
N
I
I
L
Y
GEGWDMGTG--LA--PY--DKAKKDNAYQMPNIGFFNDNQRDAVKGG
E
V
Y
G
-
A
-----
I
---
K
S
GFVSG-A-A----------------T---------------
E
P
----
I
----
L
A
K
A
I
LGS---------RE-----------------------L----GS----YT----
H
P
N
Q
V
L
N
Y
V
E
AHDNY
N
L
H
D
L
L
A
TL---HP--------------------------D-----Q---
S
S
E
Q
I
M
R
K
V
E
T
A
T
A
M
N
L
L
M
Q
G
M
A
F
M
E
I
G
Q
E
FGR
T
K
L
V
A
TG-ENGE-----------L-------------------T
H
D
D
R
E
R
---------------
A
M
NSYNAPDSVNQV
N
W
N
LI------N----------------------------------E------R
Q
D
S
I
E
F
I
R
Q
V
I
R
LKTKTGAFSYS
S
Y
D
E
I
Y
H
H
V
F
V
------
H
S
-------A------I--EHS
G
C
L
I
Y
E
-----VHG-------------K-----------
E
H
L
L
V
V
V
NAKSE
P
Y
Q
FE------N-----A-----G
N
L
A
M
---
L
V
------TNS----------R-----------------------------SKED
N
--------------
V
L
--
N
D
I
S
L
A
V
L
SVL------
47
Fugue
77.92
30%
-29
- C1 -
-
2E8Y
1
PULA_BACSU
A:
[1-712]
-----------------------------
M
V
S
I
R
R
S
-------------
F
E
A
Y
V
D
D
M
N
I
I
T
V
L
I
P
A
E
Q
K
E
I
---
M
T
P
P
F
R
L
E
T
E
I
T
D
F
P
-
L
A
V
R
E
E
Y
S
--
L
E
A
K
Y
K
Y
V
C
V
S
D
H
P
V
T
F
G
K
I
H
----
C
V
-----------------
R
A
-----
S
-----------------------
S
--
G
----------------
H
--------------------------------
K
T
-
D
-
L
Q
I
G
A
V
I
R
T
A
A
F
D
D
E
F
Y
Y
---
D
G
-
E
L
G
A
V
Y
T
A
--
D
--
H
T
V
F
K
V
W
A
P
A
A
T
S
A
A
V
K
L
S
H
P
N
K
S
G
-----
R
T
F
Q
M
T
R
L
E
K
----------
G
V
Y
A
V
T
V
T
G
-------
D
-----
L
H
G
Y
E
Y
L
F
C
--
I
C
N
N
S
-------------
E
------
W
M
E
T
V
D
Q
Y
A
K
A
----------
V
T
V
N
G
----------
E
------------
K
------------
G
V
V
L
----------------------
R
P
D
Q
-
M
--
K
---
W
T
A
P
L
K
P
F
S
H
P
V
D
A
V
I
Y
E
T
H
L
R
D
F
S
I
H
E
N
S
G
M
I
-
N
--
K
G
K
Y
L
A
L
T
E
T
D
T
Q
T
A
N
G
S
S
S
G
L
A
Y
V
K
E
L
G
V
T
H
V
E
L
L
P
V
N
D
---------
F
A
G
V
D
E
E
K
P
--------------------------------------------------------------
L
D
A
Y
N
W
G
Y
N
P
L
H
F
F
A
P
E
G
S
Y
A
S
N
P
-----
H
D
P
Q
T
R
K
T
E
L
K
Q
M
I
N
T
L
H
Q
-
H
G
L
R
V
I
L
D
V
V
F
N
H
V
Y
K
R
E
----
N
S
P
-----
F
E
K
T
V
P
G
Y
F
F
R
H
D
E
-
C
G
K
P
S
N
G
T
G
V
G
N
D
I
A
S
E
R
R
M
A
R
K
F
I
A
D
C
V
V
Y
W
L
E
E
Y
N
V
D
G
F
R
F
D
L
L
G
I
L
D
I
D
--------
T
V
L
Y
M
K
E
K
A
T
K
A
--------------------------------------
K
--------
P
G
I
L
L
F
G
E
G
W
D
L
A
T
P
--
L
P
--
H
E
--
Q
K
A
A
L
A
N
A
P
R
M
P
G
I
G
F
F
N
D
M
F
R
D
A
V
K
G
-
N
T
F
H
-
L
-----
K
---
A
T
G
F
A
L
G
N
G
-
E
----------------
S
---------------
A
Q
----
A
----
V
M
H
G
I
A
G
S
---------
S
G
-----------------------
W
----
K
A
LAPI
V
P
----
E
P
S
Q
S
I
N
Y
V
E
S
H
D
N
H
T
F
W
D
K
M
S
F
A
---
L
P
--------------------------
Q
-----
E
---
N
D
S
R
K
R
S
R
Q
R
L
A
V
A
I
I
L
L
A
Q
G
V
P
F
I
H
S
G
Q
E
F
F
R
T
K
----------------------------------------------
Q
G
---------------
V
E
N
S
Y
Q
S
S
D
S
I
N
Q
L
D
W
D
R
R
------
E
----------------------------------
T
------
F
K
E
D
V
H
Y
I
R
R
L
I
S
L
R
K
A
H
P
A
F
R
L
R
S
A
A
D
I
Q
R
H
L
E
C
------
L
T
-------
L
----------
K
E
H
L
I
A
Y
R
-----
L
Y
D
LDEVDE-------
W
-----------
K
D
I
I
V
I
H
H
A
S
P
D
S
V
E
W
R
L
P----
N
-----
D
-----
I
P
Y
R
L
---
L
C
------
D
P
S
----------
G
-----------------------------
F
Q
E
D
P
--------------
T
E
I
K
K
T
V
A
V
N
G
I
G
T
V
I
L
Y
L
A
S
29
HHSearch
75.77
36%
10
* C1 *
-
3WDH
-
?
A:
[86-709]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
-
V
P
L
Q
V
G
A
V
M
R
T
K
A
F
D
D
L
Y
A
Y
---
D
G
N
D
L
G
A
T
Y
D
P
--
E
--
K
T
T
F
K
V
W
A
P
T
A
T
D
V
L
L
K
L
I
H
P
T
T
K
----
E
E
T
T
Y
V
M
T
R
E
----------
K
K
G
L
W
T
Y
T
V
Y
D
-------
D
-----
V
E
R
F
L
Y
T
Y
M
--
T
Y
V
N
F
-------------
I
------
W
R
E
A
V
D
P
Y
A
K
S
----------
V
S
V
N
G
----------
T
------------
Y
------------
G
V
V
V
D
L
------------
A
--
K
T
N
---
I
P
K
P
S
--
M
---
S
L
-----
F
I
S
M
T
D
A
I
I
Y
E
M
H
I
R
D
F
T
I
H
H
E
S
G
V
---
R
Q
K
G
K
Y
V
G
L
T
E
R
G
T
T
G
P
N
G
T
L
T
G
L
S
Y
I
K
Q
L
G
V
T
H
V
Q
L
M
P
V
Q
D
---------
F
-
E
G
V
D
E
L
Q
P-------------------------------------------------------------
L
K
M
Y
N
W
G
Y
N
T
V
H
Y
N
A
P
E
G
S
Y
A
T
D
P
-----
D
D
P
Y
A
R
I
I
E
L
K
R
A
I
R
A
F
Q
Q
-
E
G
I
R
V
I
L
D
V
V
Y
N
H
V
Y
V
R
E
----
T
S
S
-----
F
E
H
L
V
P
G
Y
Y
F
R
Y
E
R
-
N
G
Y
P
S
N
G
T
G
V
G
N
D
L
A
S
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K
M
V
K
K
F
I
I
D
S
V
T
Y
W
L
K
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Y
G
V
D
G
F
R
F
D
L
M
G
I
L
D
I
D
--------
T
M
N
D
V
R
R
A
I
D
E
I
--------------------------------------
D
--------
P
T
V
I
I
L
G
E
G
W
D
L
A
T
P
--
L
P
--
S
E
--
K
K
T
T
I
A
N
A
K
H
T
P
R
I
A
Y
F
N
D
R
F
R
D
Y
V
K
G
S
-
T
F
D
-
I
-----
H
---
E
R
G
F
A
L
G
-
D
-
C
----------------
S
---------------
Y
K
E
---
A
----
V
I
G
A
I
R
G
S
---------
I
-----------------------------
H
L
----
F
F
----
S
P
R
Q
S
V
N
Y
V
E
C
H
D
N
H
T
L
W
D
K
M
A
V
A
---
N
A
--------------------------
H
-----
E
---
S
E
Y
I
R
R
K
R
Q
K
L
A
T
A
I
V
L
L
S
Q
G
I
P
F
L
H
S
G
Q
E
F
Y
R
T
K
K
G
-------------------------------------------------------------
V
E
N
S
Y
N
S
P
D
E
V
N
Q
V
D
W
N
E
K
------
S
----------------------------------
R
------
W
E
E
D
V
R
E
I
M
K
L
I
E
L
R
K
K
H
G
A
F
R
F
L
T
A
D
Q
V
R
R
H
M
K
F
------
Y
D
-------
T
----------
H
P
S
V
I
A
Y
Q
-----
L
V
D
-------------
V
GVYGPW-----
K
Q
I
V
V
V
Y
H
N
E
E
K
K
A
M
L
P
L
-----
A
-----
D
-----
G
K
W
K
V
---
M
F
------
S
S
E
LG
N
-------
V
-----------------------------
C
E
Q
F
I
--------------
E
I
--
N
G
I
G
A
W
V
L
I
Q
-------
35
HHSearch
75.18
30%
35
- C1 -
-
2YA2
2
?
A:
[3-705]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
R
L
K
D
E
T
Y
S
Y
---
D
G
-
K
L
G
A
D
L
K
E
EG
K
--
Q
V
D
L
T
L
W
S
P
S
A
D
K
V
S
V
V
V
Y
D
K
N
D
P
D
-
K
-
V
V
G
T
V
A
L
E
K
G
----------
E
R
G
T
W
K
Q
T
L
D
S
TNKLGIT
D
-----
F
T
G
Y
Y
Y
Q
Y
Q
--
I
E
R
Q
G
-------------
K
------
T
V
L
A
L
D
P
Y
A
K
S
----------
L
A
A
W
N
----------
S
D-----------
D
SKIDDAHK
V
A
K
-
A
A
F
V
D
P
------------
A
--
K
L
G
P
Q
D
L
T
Y
G
K
--
I
---
H
N
-----
F
K
T
R
E
D
A
V
I
Y
E
A
H
V
R
D
F
T
S
D
P
A
I
A
K
D
L
T
K
P
F
G
T
F
E
A
F
I
-----------
E
K
L
D
Y
L
K
D
L
G
V
T
H
I
Q
L
L
P
V
L
S
---------
Y
-
Y
F
V
N
E
L
K
NHERLSDYASS---------------------------------------------------
N
S
N
Y
N
W
G
Y
D
P
Q
N
Y
F
S
L
T
G
M
Y
S
S
D
P
-----
K
N
P
E
K
R
I
A
E
F
K
N
L
I
N
E
I
H
K
-
R
G
M
G
A
I
L
D
V
V
Y
N
H
T
A
K
------
V
D
L
-----
F
E
D
L
E
P
N
Y
Y
H
F
M
D
A
-
D
G
T
P
R
T
S
-
F
G
G
G
R
L
G
T
T
H
H
M
T
K
R
L
L
I
D
S
I
K
Y
L
V
D
T
Y
K
V
D
G
F
R
F
D
M
M
G
D
H
D
A
A
--------
S
I
E
E
A
Y
K
A
A
R
A
L
--------------------------------------
N
--------
P
N
L
I
M
L
G
E
G
W
R
T
Y
A
G
--
D
E
--
N
M
PT
K
A
A
D
Q
D
W
M
K
H
T
D
T
V
A
V
F
S
D
D
I
R
N
N
L
K
S
G
-
Y
P
N
-
E
-----
G
---
Q
P
A
F
I
T
G
-
G
-
K
R---------------
D
---------------
V
N
----
T
----
I
F
K
N
L
I
A
Q
---------
P
T
-----------------------
N
----
F
E
----
A
D
----
S
P
G
D
V
I
Q
Y
I
A
A
H
D
D
L
T
L
F
D
I
I
A
Q
S
---
I
K
KDPSK---------------------
A
-----
E
---
N
Y
A
E
I
H
R
R
L
R
L
G
N
L
M
V
L
T
A
Q
G
T
P
F
I
H
S
G
Q
E
Y
G
R
T
K
Q
F
R
N
P
-
A
Y
R
T
-----------
P
VAEDKVPNK
S
H
L
L
R
D
KDGN
P
F
D
Y
P
Y
F
---------------
I
H
D
S
Y
D
S
S
D
A
V
N
K
F
D
W
T
K
A
------
T
DGKAY
P
----------------------------
E
------
N
V
K
S
R
D
Y
M
K
G
L
I
A
L
R
Q
S
T
D
A
F
R
L
K
S
L
Q
D
I
K
D
R
V
H
L
------
I
T
-------
V
PGQNGV
E
--
K
E
D
V
V
I
G
Y
Q
-----
I
T
A
-------------
P
NG---------
D
I
Y
A
V
F
V
N
A
D
E
K
A
R
E
F
N
L
-----
G
TAFAH
L
-----
R
N
A
E
V
---
L
A
------
D
E
N
----------
Q
AGPVGIANPKG
L
E
W
---------------
T
E
K
G
L
--------------
K
L
--
N
A
L
T
A
T
V
L
R
V
-------
30
HHSearch
75.17
34%
-2
- C1 -
-
2E8Y
1
PULA_BACSU
A:
[82-710]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
-
T
D
L
Q
I
G
A
V
I
R
T
A
A
F
D
D
E
F
Y
Y
---
D
G
-
E
L
G
A
V
Y
T
A
--
D
--
H
T
V
F
K
V
W
A
P
A
A
T
S
A
A
V
K
L
S
H
P
N
K
S
-----
G
R
T
F
Q
M
T
R
L
----------
E
K
G
V
Y
A
V
T
V
T
G
-------
D
-----
L
H
G
Y
E
Y
L
F
C
--
I
C
N
N
S
-------------
E
------
W
M
E
T
V
D
Q
Y
A
K
A
----------
V
T
V
N
G
----------
E
------------
K
------------
G
V
V
L
R
P
------------
D
--
Q
---
M
K
W
T
A
P
L
--
K
---
P
------
F
S
H
P
V
D
A
V
I
Y
E
T
H
L
R
D
F
S
I
H
E
N
S
G
M
---
I
N
K
G
K
Y
L
A
L
T
E
T
D
T
Q
T
A
N
G
S
S
S
G
L
A
Y
V
K
E
L
G
V
T
H
V
E
L
L
P
V
N
D
---------
F
-
A
G
V
D
E
E
K
P-------------------------------------------------------------
L
D
A
Y
N
W
G
Y
N
P
L
H
F
F
A
P
E
G
S
Y
A
S
N
P
-----
H
D
P
Q
T
R
K
T
E
L
K
Q
M
I
N
T
L
H
Q
-
H
G
L
R
V
I
L
D
V
V
F
N
H
V
Y
K
R
E
----
N
S
P
-----
F
E
K
T
V
P
G
Y
F
F
R
H
D
E
-
C
G
K
P
S
N
G
T
G
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G
N
D
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A
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R
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A
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Y
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L
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Y
N
V
D
G
F
R
F
D
L
L
G
I
L
D
I
D
--------
T
V
L
Y
M
K
E
K
A
T
K
A
--------------------------------------
K
--------
P
G
I
L
L
F
G
E
G
W
D
L
A
T
P
--
L
P
--
H
E
--
Q
K
A
A
L
A
N
A
P
R
M
P
G
I
G
F
F
N
D
M
F
R
D
A
V
K
G
N
-
T
F
H
-
L
-----
K
---
A
T
G
F
A
L
G
-
N
-
G
----------------
E
S--------------
A
Q
----
A
----
V
M
H
G
I
A
G
S
---------
S
G
-----------------------
W
KALA
P
I
----
V
P
----
E
P
S
Q
S
I
N
Y
V
E
S
H
D
N
H
T
F
W
D
K
M
S
F
A
---
L
P
--------------------------
Q
-----
E
---
N
D
S
R
K
R
S
R
Q
R
L
A
V
A
I
I
L
L
A
Q
G
V
P
F
I
H
S
G
Q
E
F
F
R
T
K
Q
G
-------------------------------------------------------------
V
E
N
S
Y
Q
S
S
D
S
I
N
Q
L
D
W
D
R
R
------
E
----------------------------------
T
------
F
K
E
D
V
H
Y
I
R
R
L
I
S
L
R
K
A
H
P
A
F
R
L
R
S
A
A
D
I
Q
R
H
L
E
C
------
L
T
-------
L
----------
K
E
H
L
I
A
Y
R
-----
L
Y
D
-------------
L
DEVDEW-----
K
D
I
I
V
I
H
H
A
S
P
D
S
V
E
W
R
L
-----
P
N----
D
-----
I
P
Y
R
L
---
L
C
------
D
P
S
----------
G
FQE
D
P
T
E
----------------------
I
K
K
T
V
--------------
A
V
--
N
G
I
G
T
V
I
L
Y
L
-------
32
HHSearch
74.65
28%
9
- C1 -
-
4AIO
4
?
A:
[110-881]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
-
T
G
L
Q
L
P
G
V
L
-----
D
D
M
F
A
Y
---
T
G
-
P
L
G
A
V
F
S
E
--
D
--
S
V
S
L
H
L
W
A
P
T
A
Q
G
V
S
V
C
F
F
D
G
P
A
G
-----
P
A
L
E
T
V
Q
L
K
E
---------
S
N
G
V
W
S
V
T
G
P
R
-------
E
-----
W
E
N
R
Y
Y
L
Y
E
--
V
D
V
Y
H
-------------
P
TKAQV
L
K
C
L
A
G
D
P
Y
A
R
S
----------
L
S
A
N
G
----------
A
------------
R
------------
T
W
L
V
D
I
------------
N
NE
T
L
K
P
A
S
W
D
E
L
A
DE
K
---
P
K
-----
L
D
S
F
S
D
I
T
I
Y
E
L
H
I
R
D
F
S
A
H
D
G
T
V
-
D
-
S
D
S
R
G
G
F
R
A
F
A
Y
Q
----
A
S
A
G
M
E
H
L
R
K
L
S
D
A
G
L
T
H
V
H
L
L
P
S
F
H
---------
F
-
A
G
V
D
D
I
K
SN
W
K
F
V
D
E
C
E
L
A
T
FPPGSD
M
Q
Q
A
A
V
V
A
I
Q
E--------------------------------
E
D
P
Y
N
W
G
Y
N
P
V
L
W
G
V
P
K
G
S
Y
A
S
D
P
-----
D
G
P
-
S
R
I
I
E
Y
R
Q
M
V
Q
A
L
N
R
-
I
G
L
R
V
V
M
D
V
V
Y
N
H
L
D
S
S
G
PCGI
S
S
V
-----
L
D
K
I
V
P
G
Y
Y
V
R
R
D
T
-
N
G
Q
I
E
N
S
-
A
A
M
N
N
T
A
S
E
H
F
M
V
D
R
L
I
V
D
D
L
L
N
W
A
V
N
Y
K
V
D
G
F
R
F
D
L
M
G
H
I
M
K
R
--------
T
M
M
R
A
K
S
A
L
Q
S
L
--------------------------------------
T
TDAHGVDG
S
K
I
Y
L
Y
G
E
G
W
D
F
A
E
V
--
A
R
NQ
R
G
--
I
N
G
S
Q
L
N
M
S
G
-
T
G
I
G
S
F
N
D
R
I
R
D
A
I
N
G
G
N
P
F
G
N
P
-----
L
---
Q
Q
G
F
N
T
G
-
L
-
F
LEPNGFYQGN
E
A
D
T
R
R
S
---------------
L
A
----
T
Y
A
D
Q
I
Q
I
G
L
A
G
N
---------
L
R
DYVLISHTG
E
A
K
K
GSEIHTFDGL
P
----
V
G
Y
---
T
A
----
S
P
I
E
T
I
N
Y
V
S
A
H
D
N
E
T
L
F
D
V
I
S
V
K
---
T
P
--------------------------
M
I----
L
---
S
V
D
E
R
C
R
I
N
H
L
A
S
S
M
M
A
L
S
Q
G
I
P
F
F
H
A
G
D
E
I
L
R
S
K
S
I
-------------------------------------------------------------
D
R
D
S
Y
N
S
G
D
W
F
N
K
L
D
F
T
Y
E
------
T
NNWGVGLPPSEKNEDNWPLM
K
P
R
L
E
NPSFKPA
K
G
H
------
I
L
A
A
L
D
S
F
V
D
I
L
K
I
R
Y
S
S
P
L
F
R
L
S
T
A
N
D
I
K
Q
R
V
R
F
------
H
N
-------
T
------
G
PS
L
V
P
G
V
I
V
M
G
-----
I
E
D
ARGESPEMAQLDT
N
F----------
S
Y
V
V
T
V
F
N
V
C
P
H
E
V
S
M
D
I
-----
P
-----
A
LAS--
M
G
F
E
L
H
P
V
Q
V
------
N
S
S
D
T
L
V
R
K
S
A
--
Y
E
A---------------------------
A
T
G
R
F
--------------
T
V
--
P
G
R
T
V
S
V
F
V
E
-------
33
HHSearch
73.53
28%
8
- C1 -
-
4J3V
2
?
A:
[131-902]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
-
T
G
L
Q
L
P
G
V
L
-----
D
D
M
F
A
Y
---
T
G
-
P
L
G
A
V
F
S
E
--
D
--
S
V
S
L
H
L
W
A
P
T
A
Q
G
V
S
V
C
F
F
D
G
P
A
G
-----
P
A
L
E
T
V
Q
L
K
E
---------
S
N
G
V
W
S
V
T
G
P
R
-------
E
-----
W
E
N
R
Y
Y
L
Y
E
--
V
D
V
Y
H
-------------
P
TKAQVL
K
C
L
A
G
D
P
Y
A
R
S
----------
L
S
A
N
G
----------
A
------------
R
------------
T
W
L
V
D
I
------------
N
NE
T
L
K
P
A
S
W
D
E
L
A
DE
K
---
P
K
-----
L
D
S
F
S
D
I
T
I
Y
E
L
H
I
R
D
F
S
A
H
D
G
T
V
-
D
-
S
D
S
R
G
G
F
R
A
F
A
Y
Q
----
A
S
A
G
M
E
H
L
R
K
L
S
D
A
G
L
T
H
V
H
L
L
P
S
F
H
---------
F
-
A
G
V
D
D
I
K
SN
W
K
F
V
D
E
C
E
L
A
T
FPPGSD
M
Q
Q
A
A
V
V
A
I
Q
E--------------------------------
E
D
P
Y
N
W
G
Y
N
P
V
L
W
G
V
P
K
G
S
Y
A
S
D
P
-----
D
G
P
-
S
R
I
I
E
Y
R
Q
M
V
Q
A
L
N
R
-
I
G
L
R
V
V
M
D
V
V
Y
N
H
L
D
S
S
G
PCGI
S
S
V
-----
L
D
K
I
V
P
G
Y
Y
V
R
R
D
T
-
N
G
Q
I
E
N
S
-
A
A
M
N
N
T
A
S
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H
F
M
V
D
R
L
I
V
D
D
L
L
N
W
A
V
N
Y
K
V
D
G
F
R
F
D
L
M
G
H
I
M
K
R
--------
T
M
M
R
A
K
S
A
L
Q
S
L
--------------------------------------
T
TDAHGVDG
S
K
I
Y
L
Y
G
E
G
W
D
F
A
E
V
--
A
R
NQ
R
G
--
I
N
G
S
Q
L
N
M
S
G
-
T
G
I
G
S
F
N
D
R
I
R
D
A
I
N
G
G
N
P
F
G
N
P
-----
L
---
Q
Q
G
F
N
T
G
-
L
-
F
LEPNGFYQGN
E
A
D
T
R
R
S
---------------
L
A
T
Y
A
D
Q
----
I
Q
I
G
L
A
G
N
---------
L
R
DYVLISHTG
E
A
K
K
GSEIHTFDGL
P
----
V
G
Y
---
T
A
----
S
P
I
E
T
I
N
Y
V
S
A
H
D
N
E
T
L
F
D
V
I
S
V
K
---
T
P
--------------------------
M
I----
L
---
S
V
D
E
R
C
R
I
N
H
L
A
S
S
M
M
A
L
S
Q
G
I
P
F
F
H
A
G
D
E
I
L
R
S
K
S
I
-------------------------------------------------------------
D
R
D
S
Y
N
S
G
D
W
F
N
K
L
D
F
T
Y
E
------
T
NNWGVGLPPSEKNEDN
W
P
L
M
K
P
R
L
E
NPSFKPA
K
G
H
------
I
L
A
A
L
D
S
F
V
D
I
L
K
I
R
Y
S
S
P
L
F
R
L
S
T
A
N
D
I
K
Q
R
V
R
F
------
H
N
-------
T
------
G
PS
L
V
P
G
V
I
V
M
G
-----
I
E
D
ARGESPEMAQLDT
N
F----------
S
Y
V
V
T
V
F
N
V
C
P
H
E
V
S
M
D
I
-----
P
-----
A
LAS--
M
G
F
E
L
H
P
V
Q
V
------
N
S
S
D
T
L
V
R
K
S
A
Y
E
A
-----------------------------
A
T
G
R
F
--------------
T
V
--
P
G
R
T
V
S
V
F
V
E
-------
34
HHSearch
73.01
30%
34
- C1 -
-
2YA0
4
?
A:
[2-704]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
R
L
K
D
E
T
Y
S
Y
---
D
G
-
K
L
G
A
D
L
K
E
EG
K
--
Q
V
D
L
T
L
W
S
P
S
A
D
K
V
S
V
V
V
Y
D
K
N
D
P
D
-
K
-
V
V
G
T
V
A
L
E
K
G
----------
E
R
G
T
W
K
Q
T
L
D
S
TNKLGIT
D
-----
F
T
G
Y
Y
Y
Q
Y
Q
--
I
E
R
Q
G
-------------
K
------
T
V
L
A
L
D
P
Y
A
K
S
----------
L
A
A
W
N
----------
S
DDSKIDDAHK
V
A
K
------------
A
A
F
V
D
P
------------
A
--
K
L
---
G
P
Q
D
L
T
--
Y
G
KI
H
N
-----
F
K
T
R
E
D
A
V
I
Y
E
A
H
V
R
D
F
T
S
D
P
A
I
A
K
D
L
T
K
P
F
G
T
F
E
A
F
I
-----------
E
K
L
D
Y
L
K
D
L
G
V
T
H
I
Q
L
L
P
V
L
S
---------
Y
-
Y
F
V
N
E
L
K
NHERLSDYASS---------------------------------------------------
N
S
N
Y
N
W
G
Y
D
P
Q
N
Y
F
S
L
T
G
M
Y
S
S
D
P
-----
K
N
P
E
K
R
I
A
E
F
K
N
L
I
N
E
I
H
K
-
R
G
M
G
A
I
L
D
V
V
Y
N
H
T
A
K
------
V
D
L
-----
F
E
D
L
E
P
N
Y
Y
H
F
M
D
A
-
D
G
T
P
R
T
S
-
F
G
G
G
R
L
G
T
T
H
H
M
T
K
R
L
L
I
D
S
I
K
Y
L
V
D
T
Y
K
V
D
G
F
R
F
D
M
M
G
D
H
D
A
A
--------
S
I
E
E
A
Y
K
A
A
R
A
L
--------------------------------------
N
--------
P
N
L
I
M
L
G
E
G
W
R
T
Y
A
G
--
D
E
--
N
M
P
T
K
A
A
D
Q
D
W
M
K
H
T
D
T
V
A
V
F
S
D
D
I
R
N
N
L
K
S
G
-
Y
P
N
-
E
-----
G
---
Q
P
A
F
I
T
G
-
G
-
K
R---------------
D
---------------
V
N
----
T
----
I
F
K
N
L
I
A
Q
---------
P
T
-----------------------
N
----
F
E
----
A
D
----
S
P
G
D
V
I
Q
Y
I
A
A
H
D
N
L
T
L
F
D
I
I
A
Q
S
---
I
K
--------------------------
K
DPSK
A
E
---
N
Y
A
E
I
H
R
R
L
R
L
G
N
L
M
V
L
T
A
Q
G
T
P
F
I
H
S
G
Q
E
Y
G
R
T
K
Q
F
R
N
P
-
A
Y
R
T
-----------
P
VAEDKVPNK
S
H
L
L
R
D
KDGN
P
F
D
Y
P
Y
F
---------------
I
H
D
S
Y
D
S
S
D
A
V
N
K
F
D
W
T
K
A
------
T
----------------------------------
D
GKAY
P
E
N
V
K
S
R
D
Y
M
K
G
L
I
A
L
R
Q
S
T
D
A
F
R
L
K
S
L
Q
D
I
K
D
R
V
H
L
------
I
T
-------
V
PGQNGV
E
--
K
E
D
V
V
I
G
Y
Q
-----
I
T
A
-------------
P
NG---------
D
I
Y
A
V
F
V
N
A
D
E
K
A
R
E
F
N
L-----
G
TAFAH
L
-----
R
N
A
E
V
---
L
A
------
D
E
N
----------
Q
AGPVGIANPKG
L
E
W
---------------
T
E
K
G
L
--------------
K
L
--
N
A
L
T
A
T
V
L
R
V
-------
31
HHSearch
70.96
29%
35
- C1 -
-
3FAW
-
?
A:
[126-813]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Q
L
Y
A
Y
---
S
G
-
N
L
G
A
V
L
N
Q
DG
S
--
K
V
E
A
S
L
W
S
P
S
A
D
S
V
T
M
I
I
Y
D
K
D
N
Q
-
N
R
-
V
V
A
T
T
P
L
V
K
N
----------
N
K
G
V
W
Q
T
I
L
D
T
-------
K
LGIKN
Y
T
G
Y
Y
Y
L
Y
E
--
I
K
R
G
K
-------------
D
------
K
V
K
I
L
D
P
Y
A
K
S
----------
L
A
E
W
D
SNTVNDDIK
T
A
------------
K
------------
A
A
F
V
N
P
------------
S
--
Q
L
G
P
Q
N
L
S
F
A
K
--
I
---
A
N
-----
F
K
G
R
Q
D
A
V
I
Y
E
A
H
V
R
D
F
T
S
D
Q
S
L
D
G
K
L
K
N
Q
L
G
T
F
A
A
F
S
-----------
E
K
L
D
Y
L
Q
K
L
G
V
T
H
I
Q
L
L
P
V
L
S
---------
Y
-
F
Y
V
N
E
M
D
KSRSTAYTSS----------------------------------------------------
D
N
N
Y
N
W
G
Y
D
P
Q
S
Y
F
A
L
S
G
M
Y
S
E
K
P
-----
K
D
P
S
A
R
I
A
E
L
K
Q
L
I
H
D
I
H
K
-
R
G
M
G
V
I
L
D
V
V
Y
N
H
T
A
K
------
T
Y
L
-----
F
E
D
I
E
P
N
Y
Y
H
F
M
N
E
-
D
G
S
P
R
E
S
F
-
G
G
G
R
L
G
T
T
H
A
M
S
R
R
V
L
V
D
S
I
K
Y
L
T
S
E
F
K
V
D
G
F
R
F
D
M
M
G
D
H
D
A
A
--------
A
I
E
L
A
Y
K
E
A
K
A
I
--------------------------------------
N
--------
P
N
M
I
M
I
G
E
G
W
R
T
F
Q
G
--
D
Q
GK
P
V
--
K
P
A
D
Q
D
W
M
K
S
T
D
T
V
G
V
F
S
D
D
I
R
N
S
L
K
S
G
-
F
P
N
-
E
-----
G
---
T
P
A
F
I
T
G
-
G
-
P
Q---------------
S
---------------
L
Q
----
G
----
I
F
K
N
I
K
A
Q
---------
P
G
-----------------------
N
----
F
E
----
A
D
----
S
P
G
D
V
V
Q
Y
I
A
A
H
D
N
L
T
L
H
D
V
I
A
K
S
---
I
N
KDP-----------------------
K
-----
V
---
A
E
E
D
I
H
R
R
L
R
L
G
N
V
M
I
L
T
S
Q
G
T
A
F
I
H
S
G
Q
E
Y
G
R
T
K
R
L
L
N
P
D
Y
M
T
K
VSDDKLPNKAT
L
IEA----------------
V
K
E
Y
P
Y
F
---------------
I
H
D
S
Y
D
S
S
D
A
I
N
H
F
D
W
A
A
A
------
T
----------------------------------
D
NNKH
P
I
S
T
K
T
Q
A
Y
T
A
G
L
I
T
L
R
R
S
T
D
A
F
R
K
L
S
K
A
E
I
D
R
E
V
S
L
------
I
T
-------
E
VGQGDI
K
--
E
K
D
L
V
I
A
Y
Q
-----
T
I
D
-------------
S
KG---------
D
I
Y
A
V
F
V
N
A
D
S
K
A
R
N
V
L
L-----
G
-----
E
KY
K
H
L
L
K
G
Q
V
---
I
V
------
D
A
D
----------
Q
AGIKPISTPRG
V
H
F
---------------
E
K
D
S
L
--------------
L
I
--
D
P
L
T
A
I
V
I
K
V
-------
2
PsiBlast_PDB
70.23
35%
10
- C1 -
-
3WDI
4
?
A:
[86-666]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
-
V
P
L
Q
V
G
A
V
M
R
T
K
A
F
D
D
L
Y
A
Y
---
D
G
N
D
L
G
A
T
Y
D
P
--
E
--
K
T
T
F
K
V
W
A
P
T
A
T
D
V
L
L
K
L
I
H
P
T
T
K
E
E
----
T
T
Y
V
M
T
R
E
K
K
----------
G
L
W
T
Y
T
V
Y
D
-------
D
-----
V
E
R
F
L
Y
T
Y
M
T
Y
V
N
F
I
W
-------------
R
------
E
A
V
--
D
P
Y
A
K
S
----------
V
S
V
N
G
----------
T
------------
Y
------------
G
V
V
V
D
L
------------
A
--
K
T
N
I
P
K
P
S
M
-
S
--
L
---
F
I
S
M
T
-------
D
A
I
I
Y
E
M
H
I
R
D
F
T
I
H
H
E
S
G
V
R
-
Q
--
K
G
K
Y
V
G
L
T
E
R
G
T
T
G
P
N
G
T
L
T
G
L
S
Y
I
K
Q
L
G
V
T
H
V
Q
L
M
P
V
Q
D
---------
F
E
G
V
D
E
L
Q
P
--------------------------------------------------------------
L
K
M
Y
N
W
G
Y
N
T
V
H
Y
N
A
P
E
G
S
Y
A
T
D
P
-----
D
D
P
Y
A
R
I
I
E
L
K
R
A
I
R
A
F
Q
Q
-
E
G
I
R
V
I
L
D
V
V
Y
N
H
V
Y
V
R
E
----
T
S
S
-----
F
E
H
L
V
P
G
Y
Y
F
R
Y
E
R
-
N
G
Y
P
S
N
G
T
G
V
G
N
D
L
A
S
E
R
K
M
V
K
K
F
I
I
D
S
V
T
Y
W
L
K
E
Y
G
V
D
G
F
R
F
D
L
M
G
I
L
D
I
D
--------
T
M
N
D
V
R
R
A
I
D
E
I
--------------------------------------
D
--------
P
T
V
I
I
L
G
E
G
W
D
L
A
T
P
--
L
P
--
S
E
--
K
K
T
T
I
A
N
A
K
H
T
P
R
I
A
Y
F
N
D
R
F
R
D
Y
V
K
G
S
-
T
F
D
-
I
-----
H
---
E
R
G
F
A
L
G
-
D
-
C
----------------
S
Y--------------
K
E
----
A
----
V
I
G
A
I
R
G
S
---------
I
H
-----------------------
L
----------
F
F
----
S
P
R
Q
S
V
N
Y
V
E
C
H
D
N
H
T
L
W
D
K
M
A
V
A
---
N
A
--------------------------
H
-----
E
---
S
E
Y
I
R
R
K
R
Q
K
L
A
T
A
I
V
L
L
S
Q
G
I
P
F
L
H
S
G
Q
E
F
Y
R
T
K
----------------------------------------------
K
G
---------------
V
E
N
S
Y
N
S
P
D
E
V
N
Q
V
D
W
N
E
K
------
S
----------------------------------
R
------
W
E
E
D
V
R
E
I
M
K
L
I
E
L
R
K
K
H
G
A
F
R
F
L
T
A
D
Q
V
R
R
H
M
K
F
------
Y
D
-------
T
----------
H
P
S
V
I
A
Y
Q
LVDVG
V
Y
G
-------------
P
-----------
W
K
Q
I
V
V
V
-------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
70.06
33%
-26
- C1 -
-
2E8Y
1
PULA_BACSU
A:
[91-639]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
R
T
A
A
F
D
D
E
F
Y
Y
---
D
G
-
E
L
G
A
V
Y
T
A
--
D
--
H
T
V
F
K
V
W
A
P
A
A
T
S
A
A
V
K
L
--
S
H
P
N
K
S
G
---
R
T
F
Q
M
T
R
L
E
K
----------
G
V
Y
A
V
T
V
T
G
-------
D
-----
L
H
G
Y
E
Y
L
F
C
--
I
C
N
N
S
-------------
E
------
W
M
E
T
V
D
Q
Y
A
K
A
----------
V
T
V
N
G
----------
E
------------
K
------------
G
V
V
L
R
P
------------
D
--
Q
M
K
--------------
W
T
A
P
L
K
P
F
S
H
P
V
D
A
V
I
Y
E
T
H
L
R
D
F
S
I
H
E
N
S
G
M
I
-
N
--
K
G
K
Y
L
A
L
T
E
T
D
T
Q
T
A
N
G
S
S
S
G
L
A
Y
V
K
E
L
G
V
T
H
V
E
L
L
P
V
N
D
---------
F
A
G
V
D
E
E
K
P
--------------------------------------------------------------
L
D
A
Y
N
W
G
Y
N
P
L
H
F
F
A
P
E
G
S
Y
A
S
N
P
-----
H
D
P
Q
T
R
K
T
E
L
K
Q
M
I
N
T
L
H
Q
-
H
G
L
R
V
I
L
D
V
V
F
N
H
V
Y
K
R
E
----
N
S
P
-----
F
E
K
T
V
P
G
Y
F
F
R
H
D
E
-
C
G
K
P
S
N
G
T
G
V
G
N
D
I
A
S
E
R
R
M
A
R
K
F
I
A
D
C
V
V
Y
W
L
E
E
Y
N
V
D
G
F
R
F
D
L
L
G
I
L
D
I
D
--------
T
V
L
Y
M
K
E
K
A
T
K
A
--------------------------------------
K
--------
P
G
I
L
L
F
G
E
G
W
D
L
A
T
P
--
L
P
--
H
E
--
Q
K
A
A
L
A
N
A
P
R
M
P
G
I
G
F
F
N
D
M
F
R
D
A
V
K
G
N
-
T
F
H
-
L
-----
K
---
A
T
G
F
A
L
G
N
G
-
E
----------------
S
---------------
A
Q
----
A
----
V
M
H
G
I
A
G
S
---------
S
G
-----------------------
W
----
K
A
----
L
A
PIVP
E
P
S
Q
S
I
N
Y
V
E
S
H
D
N
H
T
F
W
D
K
M
S
F
A
---
L
P
--------------------------
Q
-----
E
---
N
D
S
R
K
R
S
R
Q
R
L
A
V
A
I
I
L
L
A
Q
G
V
P
F
I
H
S
G
Q
E
F
F
R
T
K
----------------------------------------------
Q
G
---------------
V
E
N
S
Y
Q
S
S
D
S
I
N
Q
L
D
W
D
R
R
------
E
----------------------------------
T
------
F
K
E
D
V
H
Y
I
R
R
L
I
S
L
R
K
A
H
P
A
F
R
L
R
S
A
A
D
I
Q
R
H
L
E
C
------
L
T
-------
L
------
K
--
E
H
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
PsiBlast_CBE
69.92
33%
-25
- C1 -
-
2E8Z
2
PULA_BACSU
B:
[91-639]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
R
T
A
A
F
D
D
E
F
Y
Y
---
D
G
-
E
L
G
A
V
Y
T
A
--
D
--
H
T
V
F
K
V
W
A
P
A
A
T
S
A
A
V
K
L
--
S
H
P
N
K
S
G
---
R
T
F
Q
M
T
R
L
E
K
----------
G
V
Y
A
V
T
V
T
G
-------
D
-----
L
H
G
Y
E
Y
L
F
C
--
I
C
N
N
S
-------------
E
------
W
M
E
T
V
D
Q
Y
A
K
A
----------
V
T
V
N
G
----------
E
------------
K
------------
G
V
V
L
R
P
------------
D
--
Q
M
K
--------------
W
T
A
P
L
K
P
F
S
H
P
V
D
A
V
I
Y
E
T
H
L
R
D
F
S
I
H
E
N
S
G
M
I
-
N
--
K
G
K
Y
L
A
L
T
E
T
D
T
Q
T
A
N
G
S
S
S
G
L
A
Y
V
K
E
L
G
V
T
H
V
E
L
L
P
V
N
D
---------
F
A
G
V
D
E
E
K
P
--------------------------------------------------------------
L
D
A
Y
N
W
G
Y
N
P
L
H
F
F
A
P
E
G
S
Y
A
S
N
P
-----
H
D
P
Q
T
R
K
T
E
L
K
Q
M
I
N
T
L
H
Q
-
H
G
L
R
V
I
L
D
V
V
F
N
H
V
Y
K
R
E
----
N
S
P
-----
F
E
K
T
V
P
G
Y
F
F
R
H
D
E
-
C
G
K
P
S
N
G
T
G
V
G
N
D
I
A
S
E
R
R
M
A
R
K
F
I
A
D
C
V
V
Y
W
L
E
E
Y
N
V
D
G
F
R
F
D
L
L
G
I
L
D
I
D
--------
T
V
L
Y
M
K
E
K
A
T
K
A
--------------------------------------
K
--------
P
G
I
L
L
F
G
E
G
W
D
L
A
T
P
--
L
P
--
H
E
--
Q
K
A
A
L
A
N
A
P
R
M
P
G
I
G
F
F
N
D
M
F
R
D
A
V
K
G
N
-
T
F
H
-
L
-----
K
---
A
T
G
F
A
L
G
N
G
-
E
----------------
S
---------------
A
Q
----
A
----
V
M
H
G
I
A
G
S
---------
S
G
-----------------------
W
----
K
A
----
L
A
PIVP
E
P
S
Q
S
I
N
Y
V
E
S
H
D
N
H
T
F
W
D
K
M
S
F
A
---
L
P
--------------------------
Q
-----
E
---
N
D
S
R
K
R
S
R
Q
R
L
A
V
A
I
I
L
L
A
Q
G
V
P
F
I
H
S
G
Q
E
F
F
R
T
K
----------------------------------------------
Q
G
---------------
V
E
N
S
Y
Q
S
S
D
S
I
N
Q
L
D
W
D
R
R
------
E
----------------------------------
T
------
F
K
E
D
V
H
Y
I
R
R
L
I
S
L
R
K
A
H
P
A
F
R
L
R
S
A
A
D
I
Q
R
H
L
E
C
------
L
T
-------
L
------
K
--
E
H
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
28
HHSearch
69.72
27%
26
- C1 -
-
2FHF
3
PULA_KLEAE
A:
[51-1068]
--
A
R
Q
A
V
I
H
L
V
D
I
A
G
ITS
S
T
P
A
D
Y
A
T
K
N
L
Y
L
W
N
N
E
T
CDALSAPVADWND
V
S
T
T
P
T
G
S
D
K
Y
G
P
Y
W
V
I
P
L
T
K
E
--
S
G
C
I
N
V
I
V
R
D
G
T
N
-
K
L
I
D
S
D
L
R
V
S
F
SD
F
T
D
R
T
V
S
V
I
A
G
N
S
A
V
Y
D
S
R
A
D
A
F
R
A
A
F
GVALADAHWVDKT
T
L
L
W
P
G
GENKP
I
V
R
L
Y
Y
S
HS
S
K
V
A
A
D
SNGEFS
D
K
Y
V
K
L
T
P
T
T
V
N
Q
Q
V
S
M
R
FPHLA
S
Y
P
A
F
K
L
P
DDVN
V
D
E
L
L
Q
G
E
T
V
A
I
A
A
E
SDGILS
S
A
-
T
Q
V
Q
T
A
G
V
L
D
-----
D
T
Y
A
A
A
A
E
A
L
-
S
Y
G
A
Q
L
T
D
--
S
--
G
V
T
F
R
V
W
A
P
T
A
Q
Q
V
E
L
V
I
Y
S
A
D
K
K
----
V
I
A
S
H
P
M
T
R
D
S
---------
A
S
G
A
W
S
W
Q
G
G
S
-------
D
-----
L
K
G
A
F
Y
R
Y
A
--
M
T
V
Y
H
PQSRKV-------
E
------
Q
Y
E
V
T
D
P
Y
A
H
S
----------
L
S
T
N
S
----------
E
------------
Y
------------
S
Q
V
V
D
L
------------
N
DS
A
L
K
P
E
G
W
D
G
L
T
--
M
---
P
H
-
A
Q
K
T
K
A
D
L
A
K
M
T
I
H
E
S
H
I
R
D
L
S
A
W
D
Q
T
-
V
P
-
A
E
L
R
G
K
Y
L
A
L
T
A
Q
E
----
S
N
M
V
Q
H
L
K
Q
L
S
A
S
G
V
T
H
I
E
L
L
P
V
F
D
---------
L
-
A
T
V
N
E
F
S
DKVADIQQP
F
S
R
L
C
E
V
N
SAVKSSEFAGYCDSGST
V
E
E
V
L
T
Q
L
KQNDSKDNP
Q
V
Q
A
L
N
T
L
V
A
Q
T
D
S
Y
N
W
G
Y
D
P
F
H
Y
T
V
P
E
G
S
Y
A
T
D
P
-----
E
-
G
T
A
R
I
K
E
F
R
T
M
I
Q
A
I
K
Q
D
L
G
M
N
V
I
M
D
V
V
Y
N
H
T
N
A
A
-----
G
P
T
DRTSV
L
D
K
I
V
P
W
Y
Y
Q
R
L
N
E
T
T
G
S
V
E
-
S
A
T
C
C
S
D
S
A
P
E
H
R
M
F
A
K
L
I
A
D
S
L
A
V
W
T
T
D
Y
K
I
D
G
F
R
F
D
L
M
L
Y
H
P
K
A
--------
Q
I
L
S
A
W
E
R
I
K
A
L
--------------------------------------
N
--------
P
D
I
Y
F
F
G
E
G
W
D
S
N
Q
S
--
D
R
---
F
--
E
I
A
S
Q
I
N
L
K
G
T
-
G
I
G
T
F
S
D
R
L
R
D
A
V
R
G
G
G
P
F
D
-
S
GD
A
L
R
Q
---
N
Q
G
V
G
S
G
-
A
-
G
----------------
V
LPNELTTLS
D
D
Q
A
R
H
L
A
----
D
L
---
T
R
L
G
M
A
G
N
---------
L
A
D
F
V
L
I
D
KDG
A
V
K
R
GSEIDYNGA-
P
----
G
G
Y
---
A
A
----
D
P
T
E
V
V
N
Y
V
S
K
H
D
N
Q
T
L
W
D
M
I
S
Y
K
---
A
A
Q-------------------------
E
-----
A
---
D
L
D
T
R
V
R
M
Q
A
V
S
L
A
T
V
M
L
G
Q
G
I
A
F
D
Q
Q
G
S
E
L
L
R
S
K
S
F
-------------------------------------------------------------
T
R
D
S
Y
D
S
G
D
W
F
N
R
V
D
Y
S
L
Q
------
D
NNYNVGMPRSSDDGSN
Y
D
I
I
A
R
V
KDAVATPG
E
T
-
E
------
L
K
Q
M
T
A
F
Y
Q
E
L
T
A
L
R
K
S
S
P
L
F
T
L
G
D
G
A
T
V
M
K
R
V
D
F
------
R
N
-------
T
------
G
AD
Q
Q
T
G
L
L
V
M
T
-----
I
D
D
-------------
G
MQAGASLDSRV
D
G
I
V
V
A
I
N
A
A
P
E
S
R
T
L
Q
D-----
F
-----
A
G----
T
S
L
Q
L
---
S
A
I
Q
Q
A
A
G
D
R
S
LASG
V
Q
V
---
A
-----------------------------
A
D
G
S
V
--------------
T
L
--
P
A
W
S
V
A
V
L
E
L
-------
23
PsiBlast_CBE
69.32
33%
-25
- C1 -
-
2E8Y
1
PULA_BACSU
B:
[91-639]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
R
T
A
A
F
D
D
E
F
Y
Y
---
D
G
-
E
L
G
A
V
Y
T
A
--
D
--
H
T
V
F
K
V
W
A
P
A
A
T
S
A
A
V
K
L
--
S
H
P
N
K
S
G
---
R
T
F
Q
M
T
R
L
E
K
----------
G
V
Y
A
V
T
V
T
G
-------
D
-----
L
H
G
Y
E
Y
L
F
C
--
I
C
N
N
S
-------------
E
------
W
M
E
T
V
D
Q
Y
A
K
A
----------
V
T
V
N
G
----------
E
------------
K
------------
G
V
V
L
R
P
------------
D
--
Q
M
K
--------------
W
T
A
P
L
K
P
F
S
H
P
V
D
A
V
I
Y
E
T
H
L
R
D
F
S
I
H
E
N
S
G
M
I
-
N
--
K
G
K
Y
L
A
L
T
E
T
D
T
Q
T
A
N
G
S
S
S
G
L
A
Y
V
K
E
L
G
V
T
H
V
E
L
L
P
V
N
D
---------
F
A
G
V
D
E
E
K
P
--------------------------------------------------------------
L
D
A
Y
N
W
G
Y
N
P
L
H
F
F
A
P
E
G
S
Y
A
S
N
P
-----
H
D
P
Q
T
R
K
T
E
L
K
Q
M
I
N
T
L
H
Q
-
H
G
L
R
V
I
L
D
V
V
F
N
H
V
Y
K
R
E
----
N
S
P
-----
F
E
K
T
V
P
G
Y
F
F
R
H
D
E
-
C
G
K
P
S
N
G
T
G
V
G
N
D
I
A
S
E
R
R
M
A
R
K
F
I
A
D
C
V
V
Y
W
L
E
E
Y
N
V
D
G
F
R
F
D
L
L
G
I
L
D
I
D
--------
T
V
L
Y
M
K
E
K
A
T
K
A
--------------------------------------
K
--------
P
G
I
L
L
F
G
E
G
W
D
L
A
T
P
--
L
P
--
H
E
--
Q
K
A
A
L
A
N
A
P
R
M
P
G
I
G
F
F
N
D
M
F
R
D
A
V
K
G
N
-
T
F
H
-
L
-----
K
---
A
T
G
F
A
L
G
N
G
-
E
----------------
S
---------------
A
Q
----
A
----
V
M
H
G
I
A
G
S
---------
S
G
-----------------------
W
----
K
A
----
L
A
PIVP
E
P
S
Q
S
I
N
Y
V
E
S
H
D
N
H
T
F
W
D
K
M
S
F
A
---
L
P
--------------------------
Q
-----
E
---
N
D
S
R
K
R
S
R
Q
R
L
A
V
A
I
I
L
L
A
Q
G
V
P
F
I
H
S
G
Q
E
F
F
R
T
K
----------------------------------------------
Q
G
---------------
V
E
N
S
Y
Q
S
S
D
S
I
N
Q
L
D
W
D
R
R
------
E
----------------------------------
T
------
F
K
E
D
V
H
Y
I
R
R
L
I
S
L
R
K
A
H
P
A
F
R
L
R
S
A
A
D
I
Q
R
H
L
E
C
------
L
T
-------
L
------
K
--
E
H
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
69.24
35%
8
- C1 -
-
3WDH
-
?
A:
[86-664]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
-
V
P
L
Q
V
G
A
V
M
R
T
K
A
F
D
D
L
Y
A
Y
---
D
G
N
D
L
G
A
T
Y
D
P
--
E
--
K
T
T
F
K
V
W
A
P
T
A
T
D
V
L
L
K
L
I
H
P
T
T
K
E
E
----
T
T
Y
V
M
T
R
E
K
K
----------
G
L
W
T
Y
T
V
Y
D
-------
D
-----
V
E
R
F
L
Y
T
Y
M
T
Y
V
N
F
I
W
-------------
R
------
E
A
V
--
D
P
Y
A
K
S
----------
V
S
V
N
G
----------
T
------------
Y
------------
G
V
V
V
D
L
------------
A
--
K
T
N
I
P
K
P
S
M
-
S
--
L
---
F
I
S
M
T
-------
D
A
I
I
Y
E
M
H
I
R
D
F
T
I
H
H
E
S
G
V
R
-
Q
--
K
G
K
Y
V
G
L
T
E
R
G
T
T
G
P
N
G
T
L
T
G
L
S
Y
I
K
Q
L
G
V
T
H
V
Q
L
M
P
V
Q
D
---------
F
E
G
V
D
E
L
Q
P
--------------------------------------------------------------
L
K
M
Y
N
W
G
Y
N
T
V
H
Y
N
A
P
E
G
S
Y
A
T
D
P
-----
D
D
P
Y
A
R
I
I
E
L
K
R
A
I
R
A
F
Q
Q
-
E
G
I
R
V
I
L
D
V
V
Y
N
H
V
Y
V
R
E
----
T
S
S
-----
F
E
H
L
V
P
G
Y
Y
F
R
Y
E
R
-
N
G
Y
P
S
N
G
T
G
V
G
N
D
L
A
S
E
R
K
M
V
K
K
F
I
I
D
S
V
T
Y
W
L
K
E
Y
G
V
D
G
F
R
F
D
L
M
G
I
L
D
I
D
--------
T
M
N
D
V
R
R
A
I
D
E
I
--------------------------------------
D
--------
P
T
V
I
I
L
G
E
G
W
D
L
A
T
P
--
L
P
--
S
E
--
K
K
T
T
I
A
N
A
K
H
T
P
R
I
A
Y
F
N
D
R
F
R
D
Y
V
K
G
S
-
T
F
D
-
I
-----
H
---
E
R
G
F
A
L
G
-
D
-
C
----------------
S
Y--------------
K
E
----
A
----
V
I
G
A
I
R
G
S
---------
I
H
-----------------------
L
----------
F
F
----
S
P
R
Q
S
V
N
Y
V
E
C
H
D
N
H
T
L
W
D
K
M
A
V
A
---
N
A
--------------------------
H
-----
E
---
S
E
Y
I
R
R
K
R
Q
K
L
A
T
A
I
V
L
L
S
Q
G
I
P
F
L
H
S
G
Q
E
F
Y
R
T
K
----------------------------------------------
K
G
---------------
V
E
N
S
Y
N
S
P
D
E
V
N
Q
V
D
W
N
E
K
------
S
----------------------------------
R
------
W
E
E
D
V
R
E
I
M
K
L
I
E
L
R
K
K
H
G
A
F
R
F
L
T
A
D
Q
V
R
R
H
M
K
F
------
Y
D
-------
T
----------
H
P
S
V
I
A
Y
Q
LVDVG
V
Y
G
-------------
P
-----------
W
K
Q
I
V
V
V
-------------------------------------------------------------------------------------------------------------------------------
21
PsiBlast_CBE
69.23
33%
-26
- C1 -
-
2E9B
1
PULA_BACSU
B:
[91-639]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
R
T
A
A
F
D
D
E
F
Y
Y
---
D
G
-
E
L
G
A
V
Y
T
A
--
D
--
H
T
V
F
K
V
W
A
P
A
A
T
S
A
A
V
K
L
--
S
H
P
N
K
S
G
---
R
T
F
Q
M
T
R
L
E
K
----------
G
V
Y
A
V
T
V
T
G
-------
D
-----
L
H
G
Y
E
Y
L
F
C
--
I
C
N
N
S
-------------
E
------
W
M
E
T
V
D
Q
Y
A
K
A
----------
V
T
V
N
G
----------
E
------------
K
------------
G
V
V
L
R
P
------------
D
--
Q
M
K
--------------
W
T
A
P
L
K
P
F
S
H
P
V
D
A
V
I
Y
E
T
H
L
R
D
F
S
I
H
E
N
S
G
M
I
-
N
--
K
G
K
Y
L
A
L
T
E
T
D
T
Q
T
A
N
G
S
S
S
G
L
A
Y
V
K
E
L
G
V
T
H
V
E
L
L
P
V
N
D
---------
F
A
G
V
D
E
E
K
P
--------------------------------------------------------------
L
D
A
Y
N
W
G
Y
N
P
L
H
F
F
A
P
E
G
S
Y
A
S
N
P
-----
H
D
P
Q
T
R
K
T
E
L
K
Q
M
I
N
T
L
H
Q
-
H
G
L
R
V
I
L
D
V
V
F
N
H
V
Y
K
R
E
----
N
S
P
-----
F
E
K
T
V
P
G
Y
F
F
R
H
D
E
-
C
G
K
P
S
N
G
T
G
V
G
N
D
I
A
S
E
R
R
M
A
R
K
F
I
A
D
C
V
V
Y
W
L
E
E
Y
N
V
D
G
F
R
F
D
L
L
G
I
L
D
I
D
--------
T
V
L
Y
M
K
E
K
A
T
K
A
--------------------------------------
K
--------
P
G
I
L
L
F
G
E
G
W
D
L
A
T
P
--
L
P
--
H
E
--
Q
K
A
A
L
A
N
A
P
R
M
P
G
I
G
F
F
N
D
M
F
R
D
A
V
K
G
N
-
T
F
H
-
L
-----
K
---
A
T
G
F
A
L
G
N
G
-
E
----------------
S
---------------
A
Q
----
A
----
V
M
H
G
I
A
G
S
---------
S
G
-----------------------
W
----
K
A
----
L
A
PIVP
E
P
S
Q
S
I
N
Y
V
E
S
H
D
N
H
T
F
W
D
K
M
S
F
A
---
L
P
--------------------------
Q
-----
E
---
N
D
S
R
K
R
S
R
Q
R
L
A
V
A
I
I
L
L
A
Q
G
V
P
F
I
H
S
G
Q
E
F
F
R
T
K
----------------------------------------------
Q
G
---------------
V
E
N
S
Y
Q
S
S
D
S
I
N
Q
L
D
W
D
R
R
------
E
----------------------------------
T
------
F
K
E
D
V
H
Y
I
R
R
L
I
S
L
R
K
A
H
P
A
F
R
L
R
S
A
A
D
I
Q
R
H
L
E
C
------
L
T
-------
L
------
K
--
E
H
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
69.11
33%
-26
- C1 -
-
2E8Z
2
PULA_BACSU
A:
[91-639]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
R
T
A
A
F
D
D
E
F
Y
Y
---
D
G
-
E
L
G
A
V
Y
T
A
--
D
--
H
T
V
F
K
V
W
A
P
A
A
T
S
A
A
V
K
L
--
S
H
P
N
K
S
G
---
R
T
F
Q
M
T
R
L
E
K
----------
G
V
Y
A
V
T
V
T
G
-------
D
-----
L
H
G
Y
E
Y
L
F
C
--
I
C
N
N
S
-------------
E
------
W
M
E
T
V
D
Q
Y
A
K
A
----------
V
T
V
N
G
----------
E
------------
K
------------
G
V
V
L
R
P
------------
D
--
Q
M
K
--------------
W
T
A
P
L
K
P
F
S
H
P
V
D
A
V
I
Y
E
T
H
L
R
D
F
S
I
H
E
N
S
G
M
I
-
N
--
K
G
K
Y
L
A
L
T
E
T
D
T
Q
T
A
N
G
S
S
S
G
L
A
Y
V
K
E
L
G
V
T
H
V
E
L
L
P
V
N
D
---------
F
A
G
V
D
E
E
K
P
--------------------------------------------------------------
L
D
A
Y
N
W
G
Y
N
P
L
H
F
F
A
P
E
G
S
Y
A
S
N
P
-----
H
D
P
Q
T
R
K
T
E
L
K
Q
M
I
N
T
L
H
Q
-
H
G
L
R
V
I
L
D
V
V
F
N
H
V
Y
K
R
E
----
N
S
P
-----
F
E
K
T
V
P
G
Y
F
F
R
H
D
E
-
C
G
K
P
S
N
G
T
G
V
G
N
D
I
A
S
E
R
R
M
A
R
K
F
I
A
D
C
V
V
Y
W
L
E
E
Y
N
V
D
G
F
R
F
D
L
L
G
I
L
D
I
D
--------
T
V
L
Y
M
K
E
K
A
T
K
A
--------------------------------------
K
--------
P
G
I
L
L
F
G
E
G
W
D
L
A
T
P
--
L
P
--
H
E
--
Q
K
A
A
L
A
N
A
P
R
M
P
G
I
G
F
F
N
D
M
F
R
D
A
V
K
G
N
-
T
F
H
-
L
-----
K
---
A
T
G
F
A
L
G
N
G
-
E
----------------
S
---------------
A
Q
----
A
----
V
M
H
G
I
A
G
S
---------
S
G
-----------------------
W
----
K
A
----
L
A
PIVP
E
P
S
Q
S
I
N
Y
V
E
S
H
D
N
H
T
F
W
D
K
M
S
F
A
---
L
P
--------------------------
Q
-----
E
---
N
D
S
R
K
R
S
R
Q
R
L
A
V
A
I
I
L
L
A
Q
G
V
P
F
I
H
S
G
Q
E
F
F
R
T
K
----------------------------------------------
Q
G
---------------
V
E
N
S
Y
Q
S
S
D
S
I
N
Q
L
D
W
D
R
R
------
E
----------------------------------
T
------
F
K
E
D
V
H
Y
I
R
R
L
I
S
L
R
K
A
H
P
A
F
R
L
R
S
A
A
D
I
Q
R
H
L
E
C
------
L
T
-------
L
------
K
--
E
H
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
68.63
35%
9
- C1 -
-
3WDJ
4
?
A:
[86-665]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
-
V
P
L
Q
V
G
A
V
M
R
T
K
A
F
D
D
L
Y
A
Y
---
D
G
N
D
L
G
A
T
Y
D
P
--
E
--
K
T
T
F
K
V
W
A
P
T
A
T
D
V
L
L
K
L
I
H
P
T
T
K
E
E
----
T
T
Y
V
M
T
R
E
K
K
----------
G
L
W
T
Y
T
V
Y
D
-------
D
-----
V
E
R
F
L
Y
T
Y
M
T
Y
V
N
F
I
W
-------------
R
------
E
A
V
--
D
P
Y
A
K
S
----------
V
S
V
N
G
----------
T
------------
Y
------------
G
V
V
V
D
L
------------
A
--
K
T
N
I
P
K
P
S
M
-
S
--
L
---
F
I
S
M
T
-------
D
A
I
I
Y
E
M
H
I
R
D
F
T
I
H
H
E
S
G
V
R
-
Q
--
K
G
K
Y
V
G
L
T
E
R
G
T
T
G
P
N
G
T
L
T
G
L
S
Y
I
K
Q
L
G
V
T
H
V
Q
L
M
P
V
Q
D
---------
F
E
G
V
D
E
L
Q
P
--------------------------------------------------------------
L
K
M
Y
N
W
G
Y
N
T
V
H
Y
N
A
P
E
G
S
Y
A
T
D
P
-----
D
D
P
Y
A
R
I
I
E
L
K
R
A
I
R
A
F
Q
Q
-
E
G
I
R
V
I
L
D
V
V
Y
N
H
V
Y
V
R
E
----
T
S
S
-----
F
E
H
L
V
P
G
Y
Y
F
R
Y
E
R
-
N
G
Y
P
S
N
G
T
G
V
G
N
D
L
A
S
E
R
K
M
V
K
K
F
I
I
D
S
V
T
Y
W
L
K
E
Y
G
V
D
G
F
R
F
D
L
M
G
I
L
D
I
D
--------
T
M
N
D
V
R
R
A
I
D
E
I
--------------------------------------
D
--------
P
T
V
I
I
L
G
E
G
W
D
L
A
T
P
--
L
P
--
S
E
--
K
K
T
T
I
A
N
A
K
H
T
P
R
I
A
Y
F
N
D
R
F
R
D
Y
V
K
G
S
-
T
F
D
-
I
-----
H
---
E
R
G
F
A
L
G
-
D
-
C
----------------
S
Y--------------
K
E
----
A
----
V
I
G
A
I
R
G
S
---------
I
H
-----------------------
L
----------
F
F
----
S
P
R
Q
S
V
N
Y
V
E
C
H
D
N
H
T
L
W
D
K
M
A
V
A
---
N
A
--------------------------
H
-----
E
---
S
E
Y
I
R
R
K
R
Q
K
L
A
T
A
I
V
L
L
S
Q
G
I
P
F
L
H
S
G
Q
E
F
Y
R
T
K
----------------------------------------------
K
G
---------------
V
E
N
S
Y
N
S
P
D
E
V
N
Q
V
D
W
N
E
K
------
S
----------------------------------
R
------
W
E
E
D
V
R
E
I
M
K
L
I
E
L
R
K
K
H
G
A
F
R
F
L
T
A
D
Q
V
R
R
H
M
K
F
------
Y
D
-------
T
----------
H
P
S
V
I
A
Y
Q
LVDVG
V
Y
G
-------------
P
-----------
W
K
Q
I
V
V
V
-------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
68.46
33%
-25
- C1 -
-
2E9B
3
PULA_BACSU
A:
[91-639]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
R
T
A
A
F
D
D
E
F
Y
Y
---
D
G
-
E
L
G
A
V
Y
T
A
--
D
--
H
T
V
F
K
V
W
A
P
A
A
T
S
A
A
V
K
L
--
S
H
P
N
K
S
G
---
R
T
F
Q
M
T
R
L
E
K
----------
G
V
Y
A
V
T
V
T
G
-------
D
-----
L
H
G
Y
E
Y
L
F
C
--
I
C
N
N
S
-------------
E
------
W
M
E
T
V
D
Q
Y
A
K
A
----------
V
T
V
N
G
----------
E
------------
K
------------
G
V
V
L
R
P
------------
D
--
Q
M
K
--------------
W
T
A
P
L
K
P
F
S
H
P
V
D
A
V
I
Y
E
T
H
L
R
D
F
S
I
H
E
N
S
G
M
I
-
N
--
K
G
K
Y
L
A
L
T
E
T
D
T
Q
T
A
N
G
S
S
S
G
L
A
Y
V
K
E
L
G
V
T
H
V
E
L
L
P
V
N
D
---------
F
A
G
V
D
E
E
K
P
--------------------------------------------------------------
L
D
A
Y
N
W
G
Y
N
P
L
H
F
F
A
P
E
G
S
Y
A
S
N
P
-----
H
D
P
Q
T
R
K
T
E
L
K
Q
M
I
N
T
L
H
Q
-
H
G
L
R
V
I
L
D
V
V
F
N
H
V
Y
K
R
E
----
N
S
P
-----
F
E
K
T
V
P
G
Y
F
F
R
H
D
E
-
C
G
K
P
S
N
G
T
G
V
G
N
D
I
A
S
E
R
R
M
A
R
K
F
I
A
D
C
V
V
Y
W
L
E
E
Y
N
V
D
G
F
R
F
D
L
L
G
I
L
D
I
D
--------
T
V
L
Y
M
K
E
K
A
T
K
A
--------------------------------------
K
--------
P
G
I
L
L
F
G
E
G
W
D
L
A
T
P
--
L
P
--
H
E
--
Q
K
A
A
L
A
N
A
P
R
M
P
G
I
G
F
F
N
D
M
F
R
D
A
V
K
G
N
-
T
F
H
-
L
-----
K
---
A
T
G
F
A
L
G
N
G
-
E
----------------
S
---------------
A
Q
----
A
----
V
M
H
G
I
A
G
S
---------
S
G
-----------------------
W
----
K
A
----
L
A
PIVP
E
P
S
Q
S
I
N
Y
V
E
S
H
D
N
H
T
F
W
D
K
M
S
F
A
---
L
P
--------------------------
Q
-----
E
---
N
D
S
R
K
R
S
R
Q
R
L
A
V
A
I
I
L
L
A
Q
G
V
P
F
I
H
S
G
Q
E
F
F
R
T
K
----------------------------------------------
Q
G
---------------
V
E
N
S
Y
Q
S
S
D
S
I
N
Q
L
D
W
D
R
R
------
E
----------------------------------
T
------
F
K
E
D
V
H
Y
I
R
R
L
I
S
L
R
K
A
H
P
A
F
R
L
R
S
A
A
D
I
Q
R
H
L
E
C
------
L
T
-------
L
------
K
--
E
H
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
49
Fugue
67.24
26%
33
- C1 -
-
3FAW
-
?
A:
[37-814]
--------------------
Q
V
Q
L
K
D
A
Q
Q
T
D
L
T
S
I
Q
-------------
A
S
F
T
T
L
D
K
T
E
I
L
K
E
L
K
V
T
D
K
N
Q
N
A
I
Q
---------------------------
I
S
D
I
T
L
D
T
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K
S
L
L
I
I
K
G
D
F
----
N
P
-----------------
K
Q
-----
G
-----------------------
H
--
F
----------------
N
--------------------------------
I
S
Y
N
G
N
N
V
T
T
R
Q
S
W
E
F
K
D
Q
L
Y
A
Y
---
S
G
-
N
L
G
A
V
L
N
Q
--
D
GS
K
V
E
A
S
L
W
S
P
S
A
D
S
V
T
M
I
I
Y
D
K
D
-
N
Q
N
R
-
V
V
A
T
T
P
L
V
K
N
N
K
----------
G
V
W
Q
T
I
L
D
T
-------
K
LGIKN
Y
T
G
Y
Y
Y
L
Y
E
--
I
K
R
G
K
-------------
D
------
K
V
K
I
L
D
P
Y
A
K
S
LAEWDSNTVN
D
D
I
K
T
----------
A
------------
K
------------
A
A
F
V
N
P
------------
S
--
Q
L
G
P
Q
N
L
S
F
-
A
--
K
---
I
A
N
----
F
K
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L
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G
K
L
K
N
Q
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F
A
A
F
S
E
K
-----------
L
D
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L
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H
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L
L
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L
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YFYVNEMDK
S
R
S
T
A
Y
T
S
S
--------------------------------------------------------------
D
N
N
Y
N
W
G
Y
D
P
Q
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Y
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A
L
S
G
M
Y
S
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P
-----
K
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P
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A
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I
A
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L
K
Q
L
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D
I
H
K
-
R
G
M
G
V
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D
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V
Y
N
H
T
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------
T
Y
L
-----
F
E
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P
N
Y
Y
H
F
M
N
E
-
D
G
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F
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M
M
G
D
H
D
A
A
--------
A
I
E
L
A
Y
K
E
A
K
A
I
--------------------------------------
N
--------
P
N
M
I
M
I
G
E
G
W
R
T
F
Q
G
D
Q
G
K
--
P
V
--
K
P
A
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D
T
V
G
V
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D
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N
S
L
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G
-
F
P
N
-
E
-----
G
---
T
P
A
F
I
T
G
-
G
P
Q
----------------
S
---------------
L
Q
----
G
----
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F
K
N
I
K
A
Q
---------
P
G
-----------------------
N
----
F
E
----
A
D
----
S
P
G
D
V
V
Q
Y
I
A
A
H
D
N
L
T
L
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V
I
A
K
S
I
NK
D
P
--------------------------
K
-----
V
---
A
E
E
D
I
H
R
R
L
R
L
G
N
V
M
I
L
T
S
Q
G
T
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G
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Y
G
R
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K
R
L
L
N
P
-
D
Y
M
T
-----------
K
-------------------
V
S
D
D
K
L
P
NKATLIEAVKEYPYF
I
H
D
S
Y
D
S
S
D
A
I
N
H
F
D
W
A
A
A
TDNNKH
P
----------------------------------
I
------
S
T
K
T
Q
A
Y
T
A
G
L
I
T
L
R
R
S
T
D
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F
R
K
L
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D
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V
S
L
ITEVGQ
G
D
-------
I
------
K
--
E
K
D
L
V
I
A
Y
Q
-----
T
I
D
-------------
S
KG---------
D
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Y
A
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F
V
N
A
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LGEKY
K
H
-----
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-----
L
K
G
Q
V
---
I
V
------
D
A
D
----------
Q
-----------------------------
A
G
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K
P
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V
H
F
E
KD
S
L
L
I
--
D
P
L
T
A
I
V
I
K
V
G
------
39
HHSearch
66.86
25%
-
- C1 -
-
4J7R
-
?
A:
[98-863]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
-
P
L
G
A
S
I
D
A
DT
G
--
A
I
N
F
S
V
F
S
S
S
A
E
S
V
S
L
V
L
F
T
E
A
D
L
N
A
G
R
A
T
F
E
I
P
L
D
P
Y
-------
V
N
R
T
G
D
V
W
H
I
M
L
P
D
-------
L
-----
R
D
D
L
L
Y
G
Y
R
--
V
E
G
V
H
QEEDKDYPG
M
R
H
D
K
------
R
R
V
V
L
D
P
Y
A
V
A
----------
V
L
N
R
R
----------
R
------------
W
GQMGPNLPYGEE
G
V
L
G
V
M
PTW
P
Q
A
A
A
A
L
P
A
A
--
R
G
S
A
F
D
W
E
G
D
T
--
P
---
L
------
N
L
P
M
E
S
L
V
I
Y
E
A
H
V
R
G
F
T
A
H
A
S
S
G
V
---
A
A
P
G
T
Y
A
G
M
V
-----------
E
R
L
D
Y
L
K
S
L
G
V
N
A
I
E
L
L
P
V
F
E
---------
F
-
N
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L
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Y
Y
S
Q
I
PGSD
Q
-------------------------------------------------------
Y
R
F
N
F
W
G
Y
S
T
V
N
Y
F
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A
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--
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-
R
G
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V
V
F
N
H
T
A
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-----
N
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R
GPTIS
F
R
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Y
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N
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QQ
Y
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A
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S
SGGAIVTAEGIMTDGAGVPTGYPLADP
P
L
V
E
S
I
S
E
DPV
L
--------
R
N
T
K
M
I
A
E
A
W
D
C
D
G
L
---
N
--
Q
---
V
G
A
-
F
P
--
H
Y
G
G
R
W
S
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W
N
G
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F
R
D
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V
R
N
F
-
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K
G
-
T
-----
D
GP
W
A
G
D
F
A
S
A
-
I
-
C
----------------
G
---------------
S
P
----
N
I---
Y
A
N
N
T
P
H
E
TDWWANNGG
R
Q
-----------------------
W
----
K
G
----
G
R
----
G
P
H
A
S
I
N
F
V
A
A
H
D
G
F
T
L
A
D
M
V
A
Y
N
---
N
K
HNEANGENNRDGEQHNNSWNCGEEGP
T
-----
T
K
W
E
V
N
R
L
R
Q
R
Q
M
R
N
L
T
G
A
L
L
L
S
C
G
V
P
M
I
N
M
G
D
E
Y
G
H
S
K
N
G
-------------------------------------------------------------
N
N
N
T
Y
C
H
D
S
E
L
N
Y
L
R
W
D
Q
L
------
A
----------------------------------
E
D-----
P
H
G
F
N
R
F
V
R
L
L
I
H
F
R
R
A
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P
A
L
Q
R
T
T
F
V
N
D
K
-
D
I
Q
W
------
H
G
ELPNTPD
W
------
T
--
D
T
S
R
L
V
A
F
T
-----
L
H
D
-------------
G
KG---------
G
G
L
Y
V
A
F
N
T
S
H
L
P
K
L
L
Q
L-----
P
KWG--
G
-----
R
V
W
Q
P
---
L
V
------
D
T
S
----------
K
VAPYDFLAVDGVLS
A
E
D
V
A
A
A
R
R
Q
M
A
M
W
T
A
D
H
T
Y
--------------
P
V
--
L
P
W
S
C
I
V
L
Q
S
-------