@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : spr1036: (2018-01-03 )
MSIITDVYAREVLDSRGNPTLEVEVYTESGAFGRGMVPSGASTGEHEAVELRDGDKSRYGGLGTQKAVDNVNNIIAEAIIGYDVRDQQAIDRAMIALDGTPNKGKLGANAILGVSIAVARAAADYLEIPLYSYLGGFNTKVLPTPMMNIINGGSHSDAPIAFQEFMILPVGAPTFKEALRYGAEIFHALKKILKSRGLETAVGDEGGFAPRFEGTEDGVETILAAIEAAGYVPGKDVFLGFDCASSEFYDKERKVYDYTKFEGEGAAVRTSAEQIDYLEELVNKYPIITIEDGMDENDWDGWKALTERLGKKVQLVGDDFFVTNTDYLARGIQEGAANSILIKVNQIGTLTETFEAIEMAKEAGYTAVVSHRSGETEDSTIADIAVATNAGQIKTGSLSRTDRIAKYNQLLRIEDQLGEVAEYRGLKSFYNLKK
Atome Classification :
(74 SA)
.........10........20........30---------.........40........50........60........70........80-.--...--.....90........100.......110.......120.......130.---..---..-----.---.-----140---.........150.......160.......170.......180.......190....--.--..--200-.--.......210.......220.......230....-...240.......250...-....-260---.----.-......270---....-...-.280.......290.......300.......310.....---..320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430..-
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
M
S
I
I
T
D
V
Y
A
R
E
V
L
DSRGN
P
T
L
E
V
E
V
Y
TESG----------AFGRGMVPSGASTGEH
E
A
V
E
LRDGDKSRYGGLG
T
Q
K
A
V
D
N
V
N
N
I
I
A
E
A
I
I--G--YDV--
R
D
Q
Q
A
I
D
R
A
M
I
A
LDGTPNKGKLGA
N
A
I
L
G
V
S
I
A
V
A
R
A
A
A
D
Y
L
E
I
P
L
Y
S
Y
---LG---GF-----N---T-----K-----VLP
T
P
M
M
N
I
INGGSHSDAP
I
A
F
Q
E
F
M
I
LPVG
A
P
T
F
K
E
A
L
R
Y
G
A
E
I
F
H
A
L
K
K
I
L
K
SR--G--LE--TA--V--GDEGGFAPRFEGT
E
D
G
V
E
T
I
L
A
A
I
E
A
AGYVPGK
D
-
V
F
L
G
F
DCASSE
F
Y
D
K
ER
K
V
-
Y
D
YT-KF----E----G-EG
A
A
VRT
S
----
A
E
Q
I
-
D
Y
L
-
E
E
L
V
NKY
P
I
I
T
IEDGMDENDW
D
G
W
K
A
L
T
E
R
LG
K
K
V
Q
LVG---D
D
F
F
V
T
N
T
D
Y
L
A
R
G
I
Q
EGAA
N
S
I
L
I
K
VNQIG
T
L
T
E
T
F
E
A
I
E
M
A
K
EAG
Y
T
A
V
V
SHRSGETEDS
T
I
A
D
I
A
V
ATNAG
Q
I
KTGSLS
R
T
D
R
I
A
K
Y
N
Q
L
L
R
I
E
D
Q
L
G
E
V
A
E
Y
R
G
L
K
S
F
YNLKK-
21
PsiBlast_CBE
98.03
100%
-70
- C1 -
-
1W6T
1
ENO_STRPN
B:
[11-442]
M
S
I
I
T
D
V
Y
A
R
E
V
L
D
S
R
G
N
P
T
L
E
V
E
V
Y
T
E
S
G
----------
A
F
G
R
G
M
V
P
S
G
---
G
E
H
E
A
V
E
L
R
D
G
D
K
S
R
Y
G
G
L
G
T
Q
K
A
V
D
N
V
N
N
I
I
A
E
A
I
I
--
G
--
Y
D
V
--
R
D
Q
Q
A
I
D
R
A
M
I
A
L
D
G
T
P
N
K
G
K
L
G
A
N
A
I
L
G
V
S
I
A
V
A
R
A
A
A
D
Y
L
E
I
P
L
Y
S
Y
---
L
G
---
G
F
-----
N
---
T
-----
K
-----
V
L
P
T
P
M
M
N
I
I
N
G
G
S
H
S
D
A
P
I
A
F
Q
E
F
M
I
L
P
V
G
A
P
T
F
K
E
A
L
R
Y
G
A
E
I
F
H
A
L
K
K
I
L
K
S
R
--
G
--
L
E
--
T
A
--
V
--
G
D
E
G
G
F
A
P
R
F
E
G
T
E
D
G
V
E
T
I
L
A
A
I
E
A
A
G
Y
V
P
G
K
D
-
V
F
L
G
F
D
C
A
S
S
E
F
Y
D
K
E
R
K
V
-
Y
D
Y
T
-
K
F
----
E
----
G
-
E
G
A
A
V
R
T
S
----
A
E
Q
I
-
D
Y
L
-
E
E
L
V
N
K
Y
P
I
I
T
I
E
D
G
M
D
E
N
D
W
D
G
W
K
A
L
T
E
R
L
G
K
K
V
Q
L
V
G
---
D
D
F
F
V
T
N
T
D
Y
L
A
R
G
I
Q
E
G
A
A
N
S
I
L
I
K
V
N
Q
I
G
T
L
T
E
T
F
E
A
I
E
M
A
K
E
A
G
Y
T
A
V
V
S
H
R
S
G
E
T
E
D
S
T
I
A
D
I
A
V
A
T
N
A
G
Q
I
K
T
G
S
L
S
R
T
D
R
I
A
K
Y
N
Q
L
L
R
I
E
D
Q
L
G
E
V
A
E
Y
R
G
L
K
S
F
Y
N
L
---
1
PsiBlast_PDB
96.96
100%
-69
- C1 -
-
1W6T
1
ENO_STRPN
A:
[11-442]
M
S
I
I
T
D
V
Y
A
R
E
V
L
D
S
R
G
N
P
T
L
E
V
E
V
Y
T
E
S
G
----------
A
F
G
R
G
M
V
P
S
G
---
G
E
H
E
A
V
E
L
R
D
G
D
K
S
R
Y
G
G
L
G
T
Q
K
A
V
D
N
V
N
N
I
I
A
E
A
I
I
--
G
--
Y
D
V
--
R
D
Q
Q
A
I
D
R
A
M
I
A
L
D
G
T
P
N
K
G
K
L
G
A
N
A
I
L
G
V
S
I
A
V
A
R
A
A
A
D
Y
L
E
I
P
L
Y
S
Y
---
L
G
---
G
F
-----
N
---
T
-----
K
-----
V
L
P
T
P
M
M
N
I
I
N
G
G
S
H
S
D
A
P
I
A
F
Q
E
F
M
I
L
P
V
G
A
P
T
F
K
E
A
L
R
Y
G
A
E
I
F
H
A
L
K
K
I
L
K
S
R
--
G
--
L
E
--
T
A
--
V
--
G
D
E
G
G
F
A
P
R
F
E
G
T
E
D
G
V
E
T
I
L
A
A
I
E
A
A
G
Y
V
P
G
K
D
-
V
F
L
G
F
D
C
A
S
S
E
F
Y
D
--
R
K
V
-
Y
D
Y
T
-
K
F
----
E
----
G
-
E
G
A
A
V
R
T
S
----
A
E
Q
I
-
D
Y
L
-
E
E
L
V
N
K
Y
P
I
I
T
I
E
D
G
M
D
E
N
D
W
D
G
W
K
A
L
T
E
R
L
G
K
K
V
Q
L
V
G
---
D
D
F
F
V
T
N
T
D
Y
L
A
R
G
I
Q
E
G
A
A
N
S
I
L
I
K
V
N
Q
I
G
T
L
T
E
T
F
E
A
I
E
M
A
K
E
A
G
Y
T
A
V
V
S
H
R
S
G
E
T
E
D
S
T
I
A
D
I
A
V
A
T
N
A
G
Q
I
K
T
G
S
L
S
R
T
D
R
I
A
K
Y
N
Q
L
L
R
I
E
D
Q
L
G
E
V
A
E
Y
R
G
L
K
S
F
Y
N
L
---
5
PsiBlast_PDB
91.29
93%
-43
- C1 -
-
3ZLG
-
ENO_STRP6
A:
[21-453]
M
S
I
I
T
D
V
Y
A
R
E
V
L
D
S
R
G
N
P
T
L
E
V
E
V
Y
T
E
S
G
----------
A
F
G
R
G
M
V
P
S
G
A
S
T
G
E
H
E
A
V
E
L
R
D
G
D
K
S
R
Y
L
G
L
G
T
Q
K
A
V
D
N
V
N
N
I
I
A
K
A
I
I
--
G
--
Y
D
V
--
R
D
Q
Q
A
I
D
R
A
M
I
A
L
D
G
T
P
N
K
G
K
L
G
A
N
A
I
L
G
V
S
I
A
V
A
R
A
A
A
D
Y
L
E
V
P
L
Y
T
Y
---
L
G
---
G
F
-----
N
---
T
-----
K
-----
V
L
P
T
P
M
M
N
I
I
N
G
G
S
H
S
D
A
P
I
A
F
Q
E
F
M
I
M
P
V
G
A
P
T
F
K
E
G
L
R
W
G
A
E
V
F
H
A
L
K
K
I
L
K
E
R
--
G
--
L
V
--
T
A
--
V
--
G
D
E
G
G
F
A
P
K
F
E
G
T
E
D
G
V
E
T
I
L
K
A
I
E
A
A
G
Y
E
A
G
E
N
G
I
M
I
G
F
D
C
A
S
S
E
F
Y
D
K
E
R
K
V
-
Y
D
Y
T
-
K
F
----
E
----
G
-
E
G
A
A
V
R
T
S
----
A
E
Q
V
-
D
Y
L
-
E
E
L
V
N
K
Y
P
I
I
T
I
E
D
G
M
D
E
N
D
W
D
G
W
K
V
L
T
E
R
L
G
K
R
V
Q
L
V
G
---
D
D
F
F
V
T
N
T
E
Y
L
A
R
G
I
K
E
N
A
A
N
S
I
L
I
K
V
N
Q
I
G
T
L
T
E
T
F
E
A
I
E
M
A
A
E
A
G
Y
T
A
V
V
S
H
R
S
G
E
T
E
D
S
T
I
A
D
I
A
V
A
T
N
A
G
Q
I
K
T
G
S
L
S
R
T
D
R
I
A
K
Y
N
Q
L
L
R
I
E
D
Q
L
G
E
V
A
Q
Y
K
G
I
K
S
F
Y
N
L
---
6
PsiBlast_PDB
91.14
83%
-65
- C1 -
-
1IYX
4
ENO_ENTHR
A:
[2-430]
-
S
I
I
T
D
V
Y
A
R
E
I
L
D
S
R
G
N
P
T
I
E
V
E
V
Y
T
E
S
G
----------
A
F
G
R
G
M
V
P
S
G
A
S
T
G
E
Y
E
A
V
E
L
R
D
G
D
K
A
R
Y
G
G
K
G
V
T
K
A
V
D
N
V
N
N
I
I
A
E
A
I
I
--
G
--
Y
D
V
--
R
D
Q
M
A
I
D
K
A
M
I
A
L
D
G
T
P
N
K
G
K
L
G
A
N
A
I
L
G
V
S
I
A
V
A
R
A
A
A
D
Y
L
E
V
P
L
Y
H
Y
---
L
G
---
G
F
-----
N
---
T
-----
K
-----
V
L
P
T
P
M
M
N
I
I
N
G
G
S
H
A
D
N
S
I
D
F
Q
E
F
M
I
M
P
V
G
A
P
T
F
K
E
A
L
R
M
G
A
E
V
F
H
A
L
A
A
I
L
K
S
R
--
G
--
L
A
--
T
S
--
V
--
G
D
E
G
G
F
A
P
N
L
G
S
N
E
E
G
F
E
V
I
I
E
A
I
E
K
A
G
Y
V
P
G
K
D
-
V
V
L
A
M
D
A
A
S
S
E
F
Y
D
K
E
K
G
V
-
Y
V
L
A
-
D
-----
S
----
G
-
E
G
E
--
K
T
T
----
D
E
M
I
-
K
F
Y
-
E
E
L
V
S
K
Y
P
I
I
S
I
E
D
G
L
D
E
N
D
W
D
G
F
K
K
L
T
D
V
L
G
D
K
V
Q
L
V
G
---
D
D
L
F
V
T
N
T
Q
K
L
S
E
G
I
E
K
G
I
A
N
S
I
L
I
K
V
N
Q
I
G
T
L
T
E
T
F
E
A
I
E
M
A
K
E
A
G
Y
T
A
V
V
S
H
R
S
G
E
T
E
D
S
T
I
S
D
I
A
V
A
T
N
A
G
Q
I
K
T
G
S
L
S
R
T
D
R
I
A
K
Y
N
Q
L
L
R
I
E
D
Q
L
G
E
V
A
E
Y
K
G
L
K
S
F
Y
N
L
K
--
28
PsiBlast_CBE
90.51
83%
-63
- C1 -
-
1IYX
3
ENO_ENTHR
B:
[2-430]
-
S
I
I
T
D
V
Y
A
R
E
I
L
D
S
R
G
N
P
T
I
E
V
E
V
Y
T
E
S
G
----------
A
F
G
R
G
M
V
P
S
G
A
S
T
G
E
Y
E
A
V
E
L
R
D
G
D
K
A
R
Y
G
G
K
G
V
T
K
A
V
D
N
V
N
N
I
I
A
E
A
I
I
--
G
--
Y
D
V
--
R
D
Q
M
A
I
D
K
A
M
I
A
L
D
G
T
P
N
K
G
K
L
G
A
N
A
I
L
G
V
S
I
A
V
A
R
A
A
A
D
Y
L
E
V
P
L
Y
H
Y
---
L
G
---
G
F
-----
N
---
T
-----
K
-----
V
L
P
T
P
M
M
N
I
I
N
G
G
S
H
A
D
N
S
I
D
F
Q
E
F
M
I
M
P
V
G
A
P
T
F
K
E
A
L
R
M
G
A
E
V
F
H
A
L
A
A
I
L
K
S
R
--
G
--
L
A
--
T
S
--
V
--
G
D
E
G
G
F
A
P
N
L
G
S
N
E
E
G
F
E
V
I
I
E
A
I
E
K
A
G
Y
V
P
G
K
D
-
V
V
L
A
M
D
A
A
S
S
E
F
Y
D
K
E
K
G
V
-
Y
V
L
A
-
D
-----
S
----
G
-
E
G
E
--
K
T
T
----
D
E
M
I
-
K
F
Y
-
E
E
L
V
S
K
Y
P
I
I
S
I
E
D
G
L
D
E
N
D
W
D
G
F
K
K
L
T
D
V
L
G
D
K
V
Q
L
V
G
---
D
D
L
F
V
T
N
T
Q
K
L
S
E
G
I
E
K
G
I
A
N
S
I
L
I
K
V
N
Q
I
G
T
L
T
E
T
F
E
A
I
E
M
A
K
E
A
G
Y
T
A
V
V
S
H
R
S
G
E
T
E
D
S
T
I
S
D
I
A
V
A
T
N
A
G
Q
I
K
T
G
S
L
S
R
T
D
R
I
A
K
Y
N
Q
L
L
R
I
E
D
Q
L
G
E
V
A
E
Y
K
G
L
K
S
F
Y
N
L
K
--
158
HHSearch
90.39
83%
-65
- C1 -
-
1IYX
3
ENO_ENTHR
B:
[2-430]
-
S
I
I
T
D
V
Y
A
R
E
I
L
D
S
R
G
N
P
T
I
E
V
E
V
Y
T
E
S
G
----------
A
F
G
R
G
M
V
P
S
G
A
S
T
G
E
Y
E
A
V
E
L
R
D
G
D
K
A
R
Y
G
G
K
G
V
T
K
A
V
D
N
V
N
N
I
I
A
E
A
I
I
--
G
--
Y
D
V
--
R
D
Q
M
A
I
D
K
A
M
I
A
L
D
G
T
P
N
K
G
K
L
G
A
N
A
I
L
G
V
S
I
A
V
A
R
A
A
A
D
Y
L
E
V
P
L
Y
H
Y
---
L
G
---
G
F
-----
N
---
T
-----
K
-----
V
L
P
T
P
M
M
N
I
I
N
G
G
S
H
A
D
N
S
I
D
F
Q
E
F
M
I
M
P
V
G
A
P
T
F
K
E
A
L
R
M
G
A
E
V
F
H
A
L
A
A
I
L
K
S
R
--
G
--
L
A
--
T
S
--
V
--
G
D
E
G
G
F
A
P
N
L
G
S
N
E
E
G
F
E
V
I
I
E
A
I
E
K
A
G
Y
V
P
G
K
D
-
V
V
L
A
M
D
A
A
S
S
E
F
Y
D
K
E
K
G
V
-
Y
V
L
A
-
D
S
------------
G
E
G
E
K
T
T
----
D
E
M
I
-
K
F
Y
-
E
E
L
V
S
K
Y
P
I
I
S
I
E
D
G
L
D
E
N
D
W
D
G
F
K
K
L
T
D
V
L
G
D
K
V
Q
L
V
G
---
D
D
L
F
V
T
N
T
Q
K
L
S
E
G
I
E
K
G
I
A
N
S
I
L
I
K
V
N
Q
I
G
T
L
T
E
T
F
E
A
I
E
M
A
K
E
A
G
Y
T
A
V
V
S
H
R
S
G
E
T
E
D
S
T
I
S
D
I
A
V
A
T
N
A
G
Q
I
K
T
G
S
L
S
R
T
D
R
I
A
K
Y
N
Q
L
L
R
I
E
D
Q
L
G
E
V
A
E
Y
K
G
L
K
S
F
Y
N
L
K
--
4
PsiBlast_PDB
89.95
93%
-38
- C1 -
-
3ZLF
-
ENO_STRP6
A:
[21-455]
M
S
I
I
T
D
V
Y
A
R
E
V
L
D
S
R
G
N
P
T
L
E
V
E
V
Y
T
E
S
G
----------
A
F
G
R
G
M
V
P
S
G
A
S
T
G
E
H
E
A
V
E
L
R
D
G
D
K
S
R
Y
L
G
L
G
T
Q
K
A
V
D
N
V
N
N
I
I
A
K
A
I
I
--
G
--
Y
D
V
--
R
D
Q
Q
A
I
D
R
A
M
I
A
L
D
G
T
P
N
K
G
K
L
G
A
N
A
I
L
G
V
S
I
A
V
A
R
A
A
A
D
Y
L
E
V
P
L
Y
T
Y
---
L
G
---
G
F
-----
N
---
T
-----
K
-----
V
L
P
T
P
M
M
N
I
I
N
G
G
S
H
S
D
A
P
I
A
F
Q
E
F
M
I
M
P
V
G
A
P
T
F
K
E
G
L
R
W
G
A
E
V
F
H
A
L
K
K
I
L
K
E
R
--
G
--
L
V
--
T
A
--
V
--
G
D
E
G
G
F
A
P
K
F
E
G
T
E
D
G
V
E
T
I
L
K
A
I
E
A
A
G
Y
E
A
G
E
N
G
I
M
I
G
F
D
C
A
S
S
E
F
Y
D
K
E
R
K
V
-
Y
D
Y
T
-
K
F
----
E
----
G
-
E
G
A
A
V
R
T
S
----
A
E
Q
V
-
D
Y
L
-
E
E
L
V
N
K
Y
P
I
I
T
I
E
D
G
M
D
E
N
D
W
D
G
W
K
V
L
T
E
R
L
G
A
R
V
Q
L
V
G
---
D
D
F
F
V
T
N
T
E
Y
L
A
R
G
I
K
E
N
A
A
N
S
I
L
I
K
V
N
Q
I
G
T
L
T
E
T
F
E
A
I
E
M
A
K
E
A
G
Y
T
A
V
V
S
H
R
S
G
E
T
E
D
S
T
I
A
D
I
A
V
A
T
N
A
G
Q
I
K
T
G
S
L
S
R
T
D
R
I
A
K
Y
N
Q
L
L
R
I
E
D
Q
L
G
E
V
A
Q
Y
K
G
I
K
S
F
Y
N
L
K
K
-
3
PsiBlast_PDB
89.86
93%
-40
- C1 -
-
3ZLH
-
ENO_STRP6
A:
[1-433]
M
S
I
I
T
D
V
Y
A
R
E
V
L
D
S
R
G
N
P
T
L
E
V
E
V
Y
T
E
S
G
----------
A
F
G
R
G
M
V
P
S
----
G
E
H
E
A
V
E
L
R
D
G
D
K
S
R
Y
L
G
L
G
T
Q
K
A
V
D
N
V
N
N
I
I
A
K
A
I
I
--
G
--
Y
D
V
--
R
D
Q
Q
A
I
D
R
A
M
I
A
L
D
G
T
P
N
K
G
K
L
G
A
N
A
I
L
G
V
S
I
A
V
A
R
A
A
A
D
Y
L
E
V
P
L
Y
T
Y
---
L
G
---
G
F
-----
N
---
T
-----
K
-----
V
L
P
T
P
M
M
N
I
I
N
G
G
S
H
S
D
A
P
I
A
F
Q
E
F
M
I
M
P
V
G
A
P
T
F
K
E
G
L
R
W
G
A
E
V
F
H
A
L
K
K
I
L
K
E
R
--
G
--
L
V
--
T
A
--
V
--
G
D
E
G
G
F
A
P
K
F
E
G
T
E
D
G
V
E
T
I
L
K
A
I
E
A
A
G
Y
E
A
G
E
N
G
I
M
I
G
F
D
C
A
S
S
E
F
Y
D
K
E
R
K
V
-
Y
D
Y
T
-
K
F
----
E
----
G
-
E
G
A
A
V
R
T
S
----
A
E
Q
V
-
D
Y
L
-
E
E
L
V
N
K
Y
P
I
I
T
I
E
D
G
M
D
E
N
D
W
D
G
W
K
V
L
T
E
R
L
G
K
R
V
Q
L
V
G
---
D
D
F
F
V
T
N
T
E
Y
L
A
R
G
I
K
E
N
A
A
N
S
I
L
I
K
V
N
Q
I
G
T
L
T
E
T
F
E
A
I
E
M
A
K
E
A
G
Y
T
A
V
V
S
H
R
S
G
E
T
E
D
S
T
I
A
D
I
A
V
A
T
N
A
G
Q
I
K
T
G
S
L
S
R
T
D
R
I
A
K
Y
N
Q
L
L
R
I
E
D
Q
L
G
E
V
A
Q
Y
K
G
I
K
S
F
Y
N
L
---
2
PsiBlast_PDB
89.78
93%
-41
- C1 -
-
4EWJ
-
?
A:
[1-433]
M
S
I
I
T
D
V
Y
A
R
E
V
L
D
S
R
G
N
P
T
L
E
V
E
V
Y
T
E
S
G
----------
A
F
G
R
G
M
V
P
S
G
---
G
E
H
E
A
V
E
L
R
D
G
D
K
S
R
Y
L
G
L
G
T
Q
K
A
V
D
N
V
N
N
V
I
A
D
A
I
I
--
G
--
F
D
V
--
R
D
Q
Q
A
I
D
R
A
M
I
A
L
D
G
T
P
N
K
G
K
L
G
A
N
A
I
L
G
V
S
I
A
V
A
R
A
A
A
D
Y
L
E
V
P
L
Y
T
Y
---
L
G
---
G
F
-----
N
---
T
-----
K
-----
V
L
P
T
P
M
M
N
I
I
N
G
G
S
H
S
D
A
P
I
A
F
Q
E
F
M
I
L
P
V
G
A
P
S
F
K
E
G
L
R
W
G
A
E
V
F
H
A
L
K
K
I
L
K
A
R
--
G
--
L
V
--
T
A
--
V
--
G
D
E
G
G
F
A
P
K
F
E
G
T
E
D
G
V
E
T
I
I
E
A
I
E
A
A
G
Y
E
A
G
E
N
G
I
M
I
G
F
D
C
A
S
S
E
F
Y
D
--
R
K
V
-
Y
D
Y
T
-
K
F
----
E
----
G
-
E
G
A
A
V
R
T
S
----
A
E
Q
I
-
D
Y
L
-
E
E
L
V
N
K
Y
P
I
I
T
I
E
D
G
M
D
E
N
D
W
D
G
W
K
A
L
T
E
R
L
G
K
R
V
Q
L
V
G
---
D
D
F
F
V
T
N
T
D
Y
L
A
R
G
I
K
E
G
A
A
N
S
I
L
I
K
V
N
Q
I
G
T
L
T
E
T
F
E
A
I
E
M
A
K
E
A
G
Y
T
A
V
V
S
H
R
S
G
E
T
E
D
S
T
I
A
D
I
A
V
A
T
N
A
G
Q
I
K
T
G
S
L
S
R
T
D
R
I
A
K
Y
N
Q
L
L
R
I
E
D
Q
L
G
E
V
A
V
Y
K
G
L
N
S
F
Y
N
L
---
31
PsiBlast_CBE
89.69
71%
-62
- C1 -
-
4A3R
1
ENO_BACSU
D:
[1-428]
M
P
Y
I
V
D
V
Y
A
R
E
V
L
D
S
R
G
N
P
T
V
E
V
E
V
Y
T
E
T
G
----------
A
F
G
R
A
L
V
P
S
G
A
S
T
G
E
Y
E
A
V
E
L
R
D
G
D
K
D
R
Y
L
G
K
G
V
L
T
A
V
N
N
V
N
E
I
I
A
P
E
L
L
--
G
--
F
D
V
--
T
E
Q
N
A
I
D
Q
L
L
I
E
L
D
G
T
E
N
K
G
K
L
G
A
N
A
I
L
G
V
S
M
A
C
A
R
A
A
A
D
F
L
Q
I
P
L
Y
Q
Y
---
L
G
---
G
F
-----
N
---
S
-----
K
-----
T
L
P
V
P
M
M
N
I
V
N
G
G
E
H
A
D
N
N
V
D
I
Q
E
F
M
I
M
P
V
G
A
P
N
F
R
E
A
L
R
M
G
A
Q
I
F
H
S
L
K
S
V
L
S
A
K
--
G
--
L
N
--
T
A
--
V
--
G
D
E
G
G
F
A
P
N
L
G
S
N
E
E
A
L
Q
T
I
V
E
A
I
E
K
A
G
F
K
P
G
E
E
-
V
K
L
A
M
D
A
A
S
S
E
F
Y
N
K
E
D
G
K
-
Y
----
H
L
----
S
----
G
-
E
G
-
V
V
K
T
S
----
A
E
M
V
-
D
W
Y
-
E
E
L
V
S
K
Y
P
I
I
S
I
E
D
G
L
D
E
N
D
W
E
G
H
K
L
L
T
E
R
L
G
K
K
V
Q
L
V
G
---
D
D
L
F
V
T
N
T
K
K
L
S
E
G
I
K
N
G
V
G
N
S
I
L
I
K
V
N
Q
I
G
T
L
T
E
T
F
D
A
I
E
M
A
K
R
A
G
Y
T
A
V
I
S
H
R
S
G
E
T
E
D
S
T
I
A
D
I
A
V
A
T
N
A
G
Q
I
K
T
G
A
P
S
R
T
D
R
V
A
K
Y
N
Q
L
L
R
I
E
D
Q
L
A
E
T
A
Q
Y
H
G
I
N
S
F
Y
N
L
---
9
PsiBlast_PDB
88.18
71%
-63
- C1 -
-
4A3R
-
ENO_BACSU
A:
[1-428]
M
P
Y
I
V
D
V
Y
A
R
E
V
L
D
S
R
G
N
P
T
V
E
V
E
V
Y
T
E
T
G
----------
A
F
G
R
A
L
V
P
S
G
A
S
T
G
E
Y
E
A
V
E
L
R
D
G
D
K
D
R
Y
L
G
K
G
V
L
T
A
V
N
N
V
N
E
I
I
A
P
E
L
L
--
G
--
F
D
V
--
T
E
Q
N
A
I
D
Q
L
L
I
E
L
D
G
T
E
N
K
G
K
L
G
A
N
A
I
L
G
V
S
M
A
C
A
R
A
A
A
D
F
L
Q
I
P
L
Y
Q
Y
---
L
G
---
G
F
-----
N
---
S
-----
K
-----
T
L
P
V
P
M
M
N
I
V
N
G
G
E
H
A
D
N
N
V
D
I
Q
E
F
M
I
M
P
V
G
A
P
N
F
R
E
A
L
R
M
G
A
Q
I
F
H
S
L
K
S
V
L
S
A
K
--
G
--
L
N
--
T
A
--
V
--
G
D
E
G
G
F
A
P
N
L
G
S
N
E
E
A
L
Q
T
I
V
E
A
I
E
K
A
G
F
K
P
G
E
E
-
V
K
L
A
M
D
A
A
S
S
E
F
Y
N
K
E
D
G
K
-
Y
----
H
L
----
S
----
G
-
E
G
-
V
V
K
T
S
----
A
E
M
V
-
D
W
Y
-
E
E
L
V
S
K
Y
P
I
I
S
I
E
D
G
L
D
E
N
D
W
E
G
H
K
L
L
T
E
R
L
G
K
K
V
Q
L
V
G
---
D
D
L
F
V
T
N
T
K
K
L
S
E
G
I
K
N
G
V
G
N
S
I
L
I
K
V
N
Q
I
G
T
L
T
E
T
F
D
A
I
E
M
A
K
R
A
G
Y
T
A
V
I
S
H
R
S
G
E
T
E
D
S
T
I
A
D
I
A
V
A
T
N
A
G
Q
I
K
T
G
A
P
S
R
T
D
R
V
A
K
Y
N
Q
L
L
R
I
E
D
Q
L
A
E
T
A
Q
Y
H
G
I
N
S
F
Y
N
L
---
14
PsiBlast_PDB
83.97
58%
-68
- C1 -
-
3UJ2
-
?
A:
[28-449]
---
I
E
K
V
I
G
R
E
I
I
D
S
R
G
N
P
T
V
E
A
E
V
Y
L
A
G
G
----------
V
T
G
R
G
T
A
P
S
G
---
G
E
F
E
A
L
E
L
R
D
G
D
K
G
R
F
G
G
K
G
V
T
K
A
V
Q
N
I
N
T
E
I
S
E
I
L
S
--
G
--
M
D
A
--
S
D
I
Y
A
V
D
R
A
M
I
D
A
D
G
T
K
D
K
S
K
F
G
A
N
A
V
L
A
V
S
I
A
C
A
K
A
A
A
A
A
L
G
V
P
L
Y
R
F
---
L
G
---
G
L
-----
N
---
A
-----
N
-----
R
L
P
V
P
M
M
N
I
L
N
G
G
A
H
A
A
N
T
V
D
V
Q
E
F
M
I
M
P
V
G
A
E
S
F
R
E
A
L
R
Q
C
T
E
V
F
H
A
L
A
G
L
L
K
S
K
--
G
--
L
A
--
T
S
--
V
--
G
D
E
G
G
F
A
P
D
L
A
S
D
E
E
A
I
E
Y
I
L
E
A
V
K
L
A
G
Y
E
P
G
R
D
-
F
V
L
A
M
D
A
A
S
S
E
W
K
G
E
K
K
G
E
-
Y
I
L
P
-
K
C
----
K
----
R
-
K
F
A
----
S
----
E
E
L
V
-
A
H
W
-
K
S
L
C
E
R
Y
P
I
V
S
I
E
D
G
L
D
E
E
D
W
E
G
W
Q
Y
M
T
R
E
L
G
D
K
I
Q
L
V
G
---
D
D
L
F
V
T
N
T
E
R
L
N
K
G
I
K
E
R
C
G
N
S
I
L
I
K
L
N
Q
I
G
T
V
S
E
T
L
E
A
I
K
M
A
H
K
A
G
Y
T
A
V
V
S
H
R
S
G
E
T
E
D
T
T
I
A
D
L
A
V
A
L
N
T
G
Q
I
K
T
G
A
P
S
R
S
E
R
V
A
K
Y
N
Q
L
L
R
I
E
E
E
L
G
D
S
A
V
Y
P
G
F
T
T
F
------
160
HHSearch
83.52
61%
-72
- C1 -
-
4Z17
1
ENO_CHLAA
A:
[2-424]
S
T
L
I
E
A
I
V
A
R
E
V
L
D
S
R
G
N
P
T
I
E
V
D
V
R
L
E
S
G
----------
D
V
G
R
A
I
V
P
S
G
A
S
T
G
A
H
E
A
L
E
L
R
D
G
D
K
S
R
Y
N
G
K
G
V
L
K
A
V
Q
A
V
N
E
D
I
A
E
A
L
I
--
G
--
F
D
A
--
A
D
Q
I
A
L
D
Q
E
L
I
A
L
D
G
T
P
N
K
S
K
L
G
A
N
A
I
L
G
V
S
L
A
A
A
K
A
A
A
A
A
F
G
L
P
L
Y
R
Y
---
L
G
---
G
V
-----
Y
---
A
-----
H
-----
V
L
P
V
P
M
M
N
I
M
N
G
G
Q
H
--
N
S
T
D
F
Q
E
F
M
I
M
P
V
G
A
E
S
F
R
E
G
L
R
W
G
A
E
I
Y
H
M
L
K
K
V
I
H
D
R
--
G
--
F
S
--
T
T
--
V
--
G
D
E
G
G
F
A
P
S
L
P
T
N
D
A
P
L
Q
L
I
M
E
A
I
E
K
A
G
Y
R
P
G
E
Q
-
I
V
I
A
L
D
P
A
T
T
E
I
F
E
--
D
G
K
-
Y
H
L
K
-
R
-------------
E
G
R
S
L
S
S
----
A
E
M
V
-
D
Y
W
-
V
D
L
V
N
R
Y
P
I
I
S
L
E
D
G
L
A
E
D
D
W
E
G
W
A
L
L
R
A
K
L
G
D
R
V
Q
L
V
G
---
D
D
F
L
V
T
N
V
Q
R
L
Q
R
A
I
E
A
K
A
A
N
S
I
L
I
K
L
N
Q
I
G
S
L
T
E
T
L
S
A
I
Q
L
A
Q
R
S
G
W
T
A
V
V
S
H
R
S
G
E
S
E
D
V
T
I
A
D
L
V
V
A
T
N
A
G
Q
I
K
T
G
A
P
A
R
T
D
R
I
A
K
Y
N
Q
L
L
R
I
E
E
E
L
G
S
A
A
R
Y
A
G
R
S
A
F
------
11
PsiBlast_PDB
83.50
61%
-67
- C1 -
-
4ROP
-
ENO_SYNP6
A:
[9-421]
---
I
A
E
I
T
A
R
E
I
L
D
S
R
G
R
P
T
V
E
A
E
V
H
L
E
D
G
----------
S
V
G
L
A
Q
V
P
S
G
A
S
T
G
T
F
E
A
H
E
L
R
D
D
D
P
S
R
Y
G
G
K
G
V
Q
K
A
V
E
N
V
S
-
A
I
E
D
A
L
I
--
G
--
L
S
A
--
L
D
Q
E
G
L
D
K
A
M
I
A
L
D
G
T
P
N
K
K
N
L
G
A
N
A
I
L
A
V
S
L
A
T
A
H
A
A
A
T
S
L
N
L
P
L
Y
R
Y
---
L
G
---
G
P
-----
L
---
A
-----
N
-----
V
L
P
V
P
M
M
N
V
I
N
G
G
A
H
A
D
N
N
V
D
F
Q
E
F
M
I
M
P
V
G
A
P
S
F
K
E
A
L
R
W
G
A
E
V
F
H
A
L
A
K
V
L
K
D
K
--
G
--
L
A
--
T
G
--
V
--
G
D
E
G
G
F
A
P
N
L
G
S
N
K
E
A
L
E
L
L
L
T
A
I
E
A
A
G
Y
K
P
G
E
Q
-
V
A
L
A
M
D
V
A
S
S
E
F
Y
K
N
G
L
Y
T
-
C
D
G
V
-
S
H
----
E
----
P
-
A
G
------------
M
I
-
G
I
L
-
A
D
L
V
S
Q
Y
P
I
V
S
I
E
D
G
L
Q
E
D
D
W
S
N
W
K
T
L
T
Q
Q
L
G
S
T
V
Q
L
V
G
---
D
D
L
F
V
T
N
P
D
R
L
Q
S
G
I
E
Q
G
V
G
N
A
V
L
I
K
L
N
Q
I
G
T
L
T
E
T
L
R
T
I
D
L
A
T
R
S
G
Y
R
S
V
I
S
H
R
S
G
E
T
E
D
T
T
I
A
D
L
A
V
A
T
R
A
G
Q
I
K
T
G
S
L
S
R
S
E
R
I
A
K
Y
N
R
L
L
R
I
E
A
A
L
G
E
N
A
L
Y
A
G
----------
13
PsiBlast_PDB
82.91
60%
-69
- C1 -
-
4Z1Y
-
ENO_CHLAA
A:
[3-424]
-
T
L
I
E
A
I
V
A
R
E
V
L
D
S
R
G
N
P
T
I
E
V
D
V
R
L
E
S
G
----------
D
V
G
R
A
I
V
P
S
G
A
S
T
G
A
H
E
A
L
E
L
R
D
G
D
K
S
R
Y
N
G
K
G
V
L
K
A
V
Q
A
V
N
E
D
I
A
E
A
L
I
--
G
--
F
D
A
--
A
D
Q
I
A
L
D
Q
E
L
I
A
L
D
G
T
P
N
K
S
K
L
G
A
N
A
I
L
G
V
S
L
A
A
A
K
A
A
A
A
A
F
G
L
P
L
Y
R
Y
---
L
G
---
G
V
-----
Y
---
A
-----
H
-----
V
L
P
V
P
M
M
N
I
M
N
G
G
Q
H
A
T
N
S
T
D
F
Q
E
F
M
I
M
P
V
G
A
E
S
F
R
E
G
L
R
W
G
A
E
I
Y
H
M
L
K
K
V
I
H
D
R
--
G
--
F
S
--
T
T
--
V
--
G
D
E
G
G
F
A
P
S
L
P
T
N
D
A
P
L
Q
L
I
M
E
A
I
E
K
A
G
Y
R
P
G
E
Q
-
I
V
I
A
L
D
P
A
T
T
E
I
F
-
D
G
K
Y
----
H
L
-
K
R
----
E
----
G
-
R
S
L
---
S
S
----
A
E
M
V
-
D
Y
W
-
V
D
L
V
N
R
Y
P
I
I
S
L
E
D
G
L
A
E
D
D
W
E
G
W
A
L
L
R
A
K
L
G
D
R
V
Q
L
V
G
---
D
D
F
L
V
T
N
V
Q
R
L
Q
R
A
I
E
A
K
A
A
N
S
I
L
I
K
L
N
Q
I
G
S
L
T
E
T
L
S
A
I
Q
L
A
Q
R
S
G
W
T
A
V
V
S
H
R
S
G
E
S
E
D
V
T
I
A
D
L
V
V
A
T
N
A
G
Q
I
K
T
G
A
P
A
R
T
D
R
I
A
K
Y
N
Q
L
L
R
I
E
E
E
L
G
S
A
A
R
Y
A
G
R
S
A
F
------
12
PsiBlast_PDB
82.72
60%
-69
- C1 -
-
4Z17
1
ENO_CHLAA
A:
[3-424]
-
T
L
I
E
A
I
V
A
R
E
V
L
D
S
R
G
N
P
T
I
E
V
D
V
R
L
E
S
G
----------
D
V
G
R
A
I
V
P
S
G
A
S
T
G
A
H
E
A
L
E
L
R
D
G
D
K
S
R
Y
N
G
K
G
V
L
K
A
V
Q
A
V
N
E
D
I
A
E
A
L
I
--
G
--
F
D
A
--
A
D
Q
I
A
L
D
Q
E
L
I
A
L
D
G
T
P
N
K
S
K
L
G
A
N
A
I
L
G
V
S
L
A
A
A
K
A
A
A
A
A
F
G
L
P
L
Y
R
Y
---
L
G
---
G
V
-----
Y
---
A
-----
H
-----
V
L
P
V
P
M
M
N
I
M
N
G
G
Q
H
--
N
S
T
D
F
Q
E
F
M
I
M
P
V
G
A
E
S
F
R
E
G
L
R
W
G
A
E
I
Y
H
M
L
K
K
V
I
H
D
R
--
G
--
F
S
--
T
T
--
V
--
G
D
E
G
G
F
A
P
S
L
P
T
N
D
A
P
L
Q
L
I
M
E
A
I
E
K
A
G
Y
R
P
G
E
Q
-
I
V
I
A
L
D
P
A
T
T
E
I
F
E
D
G
K
Y
----
H
L
-
K
R
----
E
----
G
-
R
S
L
---
S
S
----
A
E
M
V
-
D
Y
W
-
V
D
L
V
N
R
Y
P
I
I
S
L
E
D
G
L
A
E
D
D
W
E
G
W
A
L
L
R
A
K
L
G
D
R
V
Q
L
V
G
---
D
D
F
L
V
T
N
V
Q
R
L
Q
R
A
I
E
A
K
A
A
N
S
I
L
I
K
L
N
Q
I
G
S
L
T
E
T
L
S
A
I
Q
L
A
Q
R
S
G
W
T
A
V
V
S
H
R
S
G
E
S
E
D
V
T
I
A
D
L
V
V
A
T
N
A
G
Q
I
K
T
G
A
P
A
R
T
D
R
I
A
K
Y
N
Q
L
L
R
I
E
E
E
L
G
S
A
A
R
Y
A
G
R
S
A
F
------
161
HHSearch
82.02
58%
-66
- C1 -
-
3UJ2
-
?
B:
[26-449]
-
L
E
I
E
K
V
I
G
R
E
I
I
D
S
R
G
N
P
T
V
E
A
E
V
Y
L
A
G
G
----------
V
T
G
R
G
T
A
P
S
G
---
G
E
F
E
A
L
E
L
R
D
G
D
K
G
R
F
G
G
K
G
V
T
K
A
V
Q
N
I
N
T
E
I
S
E
I
L
S
--
G
--
M
D
A
--
S
D
I
Y
A
V
D
R
A
M
I
D
A
D
G
T
K
D
K
S
K
F
G
A
N
A
V
L
A
V
S
I
A
C
A
K
A
A
A
A
A
L
G
V
P
L
Y
R
F
---
L
G
---
G
L
-----
N
---
A
-----
N
-----
R
L
P
V
P
M
M
N
I
L
N
G
G
A
H
A
A
N
T
V
D
V
Q
E
F
M
I
M
P
V
G
A
E
S
F
R
E
A
L
R
Q
C
T
E
V
F
H
A
L
A
G
L
L
K
S
K
--
G
--
L
A
--
T
S
--
V
--
G
D
E
G
G
F
A
P
D
L
A
S
D
E
E
A
I
E
Y
I
L
E
A
V
K
L
A
G
Y
E
P
G
R
D
-
F
V
L
A
M
D
A
A
S
S
E
W
K
G
E
K
K
G
E
-
Y
I
L
P
-
K
-------------
C
K
R
K
F
A
S
----
E
E
L
V
-
A
H
W
-
K
S
L
C
E
R
Y
P
I
V
S
I
E
D
G
L
D
E
E
D
W
E
G
W
Q
Y
M
T
R
E
L
G
D
K
I
Q
L
V
G
---
D
D
L
F
V
T
N
T
E
R
L
N
K
G
I
K
E
R
C
G
N
S
I
L
I
K
L
N
Q
I
G
T
V
S
E
T
L
E
A
I
K
M
A
H
K
A
G
Y
T
A
V
V
S
H
R
S
G
E
T
E
D
T
T
I
A
D
L
A
V
A
L
N
T
G
Q
I
K
T
G
A
P
S
R
S
E
R
V
A
K
Y
N
Q
L
L
R
I
E
E
E
L
G
D
S
A
V
Y
P
G
F
T
T
F
------
34
PsiBlast_CBE
81.90
61%
-68
- C1 -
-
5J04
1
ENO_SYNP6
A:
[5-417]
---
I
A
E
I
T
A
R
E
I
L
D
S
R
G
R
P
T
V
E
A
E
V
H
L
E
D
G
----------
S
V
G
L
A
Q
V
P
S
G
A
S
T
G
T
F
E
A
H
E
L
R
D
D
D
P
S
R
Y
G
G
K
G
V
Q
K
A
V
E
N
V
S
-
A
I
E
D
A
L
I
--
G
--
L
S
A
--
L
D
Q
E
G
L
D
K
A
M
I
A
L
D
G
T
P
N
K
K
N
L
G
A
N
A
I
L
A
V
S
L
A
T
A
H
A
A
A
T
S
L
N
L
P
L
Y
R
Y
---
L
G
---
G
P
-----
L
---
A
-----
N
-----
V
L
P
V
P
M
M
N
V
I
N
G
G
A
H
A
D
N
N
V
D
F
Q
E
F
M
I
M
P
V
G
A
P
S
F
K
E
A
L
R
W
G
A
E
V
F
H
A
L
A
K
V
L
K
D
K
--
G
--
L
A
--
T
G
--
V
--
G
D
E
G
G
F
A
P
N
L
G
S
N
K
E
A
L
E
L
L
L
T
A
I
E
A
A
G
Y
K
P
G
E
Q
-
V
A
L
A
M
D
V
A
S
S
E
F
Y
K
N
G
L
Y
T
-
C
D
G
V
-
S
H
----
E
----
P
-
A
G
------------
M
I
-
G
I
L
-
A
D
L
V
S
Q
Y
P
I
V
S
I
E
D
G
L
Q
E
D
D
W
S
N
W
K
T
L
T
Q
Q
L
G
S
T
V
Q
L
V
G
---
D
D
L
F
V
T
N
P
D
R
L
Q
S
G
I
E
Q
G
V
G
N
A
V
L
I
K
L
N
Q
I
G
T
L
T
E
T
L
R
T
I
D
L
A
T
R
S
G
Y
R
S
V
I
S
H
R
S
G
E
T
E
D
T
T
I
A
D
L
A
V
A
T
R
A
G
Q
I
K
T
G
S
L
S
R
S
E
R
I
A
K
Y
N
R
L
L
R
I
E
A
A
L
G
E
N
A
L
Y
A
G
----------
33
PsiBlast_CBE
81.83
61%
-66
- C1 -
-
5J04
1
ENO_SYNP6
B:
[5-417]
---
I
A
E
I
T
A
R
E
I
L
D
S
R
G
R
P
T
V
E
A
E
V
H
L
E
D
G
----------
S
V
G
L
A
Q
V
P
S
G
A
S
T
G
T
F
E
A
H
E
L
R
D
D
D
P
S
R
Y
G
G
K
G
V
Q
K
A
V
E
N
V
S
-
A
I
E
D
A
L
I
--
G
--
L
S
A
--
L
D
Q
E
G
L
D
K
A
M
I
A
L
D
G
T
P
N
K
K
N
L
G
A
N
A
I
L
A
V
S
L
A
T
A
H
A
A
A
T
S
L
N
L
P
L
Y
R
Y
---
L
G
---
G
P
-----
L
---
A
-----
N
-----
V
L
P
V
P
M
M
N
V
I
N
G
G
A
H
A
D
N
N
V
D
F
Q
E
F
M
I
M
P
V
G
A
P
S
F
K
E
A
L
R
W
G
A
E
V
F
H
A
L
A
K
V
L
K
D
K
--
G
--
L
A
--
T
G
--
V
--
G
D
E
G
G
F
A
P
N
L
G
S
N
K
E
A
L
E
L
L
L
T
A
I
E
A
A
G
Y
K
P
G
E
Q
-
V
A
L
A
M
D
V
A
S
S
E
F
Y
K
N
G
L
Y
T
-
C
D
G
V
-
S
H
----
E
----
P
-
A
G
------------
M
I
-
G
I
L
-
A
D
L
V
S
Q
Y
P
I
V
S
I
E
D
G
L
Q
E
D
D
W
S
N
W
K
T
L
T
Q
Q
L
G
S
T
V
Q
L
V
G
---
D
D
L
F
V
T
N
P
D
R
L
Q
S
G
I
E
Q
G
V
G
N
A
V
L
I
K
L
N
Q
I
G
T
L
T
E
T
L
R
T
I
D
L
A
T
R
S
G
Y
R
S
V
I
S
H
R
S
G
E
T
E
D
T
T
I
A
D
L
A
V
A
T
R
A
G
Q
I
K
T
G
S
L
S
R
S
E
R
I
A
K
Y
N
R
L
L
R
I
E
A
A
L
G
E
N
A
L
Y
A
G
----------
156
HHSearch
80.61
69%
-69
- C1 -
-
4MKS
-
ENO2_LACGA
B:
[3-428]
--
V
I
T
D
I
H
A
R
E
V
L
D
S
R
G
N
P
T
A
E
A
E
V
Y
T
E
L
G
----------
G
F
G
R
A
I
V
P
S
G
A
S
T
G
E
H
E
A
V
E
L
R
D
G
D
K
S
R
F
G
G
Q
G
V
L
T
A
V
E
N
V
N
G
E
I
A
K
A
V
I
--
G
--
L
D
V
--
T
D
Q
R
L
I
D
Q
T
M
I
D
L
D
G
T
P
N
K
G
R
L
G
A
N
A
I
L
S
V
S
L
A
S
A
R
A
A
A
D
E
L
G
L
P
L
Y
E
Y
---
L
G
---
G
P
-----
N
---
A
-----
H
-----
V
L
P
T
P
M
M
N
V
I
N
G
------
N
V
D
I
Q
E
F
M
I
M
P
V
G
A
K
S
L
H
E
A
V
R
M
G
A
E
T
F
H
T
L
K
G
L
L
Q
E
R
--
G
--
E
S
--
T
A
--
V
--
G
D
E
G
G
F
A
P
---
N
N
E
E
P
F
E
I
L
V
E
A
I
Q
R
A
G
Y
K
P
G
Q
D
-
I
A
I
A
F
D
C
A
A
S
E
F
Y
---------------------------------------
W
T
-
S
L
I
-
E
D
L
V
D
K
Y
P
V
I
S
V
E
D
P
L
D
E
N
D
W
E
G
W
K
T
F
T
E
R
L
G
D
K
V
Q
I
V
G
---
D
D
L
F
V
T
N
T
S
Y
L
E
K
G
I
K
M
G
V
A
N
S
I
L
I
K
L
N
Q
I
G
T
L
T
E
T
F
E
A
I
E
M
A
K
E
A
G
Y
T
A
V
V
S
H
R
S
G
E
T
E
D
T
T
I
A
D
L
V
V
A
T
N
A
G
Q
I
K
T
G
S
M
S
R
T
D
R
I
A
K
Y
N
Q
L
M
R
I
E
E
A
L
G
S
T
A
Q
Y
K
G
I
H
S
F
Y
N
L
---
36
PsiBlast_CBE
79.63
60%
-70
- C1 -
-
4Z17
1
ENO_CHLAA
B:
[3-424]
-
T
L
I
E
A
I
V
A
R
E
V
L
D
S
R
G
N
P
T
I
E
V
D
V
R
L
E
S
G
----------
D
V
G
R
A
I
V
P
S
G
A
S
T
G
A
H
E
A
L
E
L
R
D
G
D
K
S
R
Y
N
G
K
G
V
L
K
A
V
Q
A
V
N
E
D
I
A
E
A
L
I
--
G
--
F
D
A
--
A
D
Q
I
A
L
D
Q
E
L
I
A
L
D
G
T
P
N
K
S
K
L
G
A
N
A
I
L
G
V
S
L
A
A
A
K
A
A
A
A
A
F
G
L
P
L
Y
R
Y
---
L
G
---
G
V
-----
Y
---
A
-----
H
-----
V
L
P
V
P
M
M
N
I
M
N
G
G
Q
H
A
-----
F
Q
E
F
M
I
M
P
V
G
A
E
S
F
R
E
G
L
R
W
G
A
E
I
Y
H
M
L
K
K
V
I
H
D
R
--
G
--
F
S
--
T
T
--
V
--
G
D
E
G
G
F
A
P
S
L
P
T
N
D
A
P
L
Q
L
I
M
E
A
I
E
K
A
G
Y
R
P
G
E
Q
-
I
V
I
A
L
D
P
A
T
T
E
I
F
E
D
G
K
Y
----
H
L
-
K
R
----
E
----
G
-
R
S
L
---
S
S
----
A
E
M
V
-
D
Y
W
-
V
D
L
V
N
R
Y
P
I
I
S
L
E
D
G
L
A
E
D
D
W
E
G
W
A
L
L
R
A
K
L
G
D
R
V
Q
L
V
G
---
D
D
F
L
V
T
N
V
Q
R
L
Q
R
A
I
E
A
K
A
A
N
S
I
L
I
K
L
N
Q
I
G
S
L
T
E
T
L
S
A
I
Q
L
A
Q
R
S
G
W
T
A
V
V
S
H
R
S
G
E
S
E
D
V
T
I
A
D
L
V
V
A
T
N
A
G
Q
I
K
T
G
A
P
A
R
T
D
R
I
A
K
Y
N
Q
L
L
R
I
E
E
E
L
G
S
A
A
R
Y
A
G
R
S
A
F
------
157
HHSearch
77.49
82%
12
- C1 -
-
5BOE
4
ENO_STAAU
B:
[1-433]
M
P
I
I
T
D
V
Y
A
R
E
V
L
D
S
R
G
N
P
T
V
E
V
E
V
L
T
E
S
G
----------
A
F
G
R
A
L
V
P
S
G
A
S
T
G
E
H
E
A
V
E
L
R
D
G
D
K
S
R
Y
L
G
K
G
V
T
K
A
V
E
N
V
N
E
I
I
A
P
E
I
I
--
E
--
G
E
F
SV
L
D
Q
V
S
I
D
K
M
M
I
A
L
D
G
T
P
N
K
G
K
L
G
A
N
A
I
L
G
V
S
I
A
V
A
R
A
A
A
D
L
L
G
Q
P
L
Y
K
Y
---
L
G
---
G
F
-----
N
---
G
-----
K
-----
Q
L
P
V
P
M
M
N
I
V
N
G
G
S
H
S
D
A
P
I
A
F
Q
E
F
M
I
L
P
V
G
A
T
T
F
K
E
S
L
R
W
G
T
E
I
F
H
N
L
K
S
I
L
S
K
R
--
G
--
L
E
--
T
A
--
V
--
G
D
E
G
G
F
A
P
K
F
E
G
T
E
D
A
V
E
T
I
I
Q
A
I
E
A
A
G
Y
K
P
G
E
E
-
V
F
L
G
F
D
C
A
S
S
E
F
Y
E
--
N
G
V
-
Y
D
Y
S
-
K
F
----
E
G---
E
-
H
G
-
A
K
R
T
A
----
A
E
Q
V
-
D
Y
L
-
E
Q
L
V
D
K
Y
P
I
I
T
I
E
D
G
M
D
E
N
D
W
D
G
W
K
Q
L
T
E
R
I
G
D
R
V
Q
L
V
G
D--
D
L
F
-
V
T
N
T
E
I
L
A
K
G
I
E
N
G
I
G
N
S
I
L
I
K
V
N
Q
I
G
T
L
T
E
T
F
D
A
I
E
M
A
Q
K
A
G
Y
T
A
V
V
S
H
R
S
G
E
T
E
D
T
T
I
A
D
I
A
V
A
T
N
A
G
Q
I
K
T
G
S
L
S
R
T
D
R
I
A
K
Y
N
Q
L
L
R
I
E
D
E
L
F
E
T
A
K
Y
D
G
I
K
S
F
Y
N
L
D
--
173
HHSearch
77.40
61%
-44
- C1 -
-
5J04
1
ENO_SYNP6
A:
[3-418]
-
T
Q
I
A
E
I
T
A
R
E
I
L
D
S
R
G
R
P
T
V
E
A
E
V
H
L
E
D
G
----------
S
V
G
L
A
Q
V
P
S
G
A
S
T
G
T
F
E
A
H
E
L
R
D
D
D
P
S
R
Y
G
G
K
G
V
Q
K
A
V
E
N
V
S
-
A
I
E
D
A
L
I
--
G
--
L
S
A
--
L
D
Q
E
G
L
D
K
A
M
I
A
L
D
G
T
P
N
K
K
N
L
G
A
N
A
I
L
A
V
S
L
A
T
A
H
A
A
A
T
S
L
N
L
P
L
Y
R
Y
---
L
G
---
G
P
-----
L
---
A
-----
N
-----
V
L
P
V
P
M
M
N
V
I
N
G
G
A
H
A
D
N
N
V
D
F
Q
E
F
M
I
M
P
V
G
A
P
S
F
K
E
A
L
R
W
G
A
E
V
F
H
A
L
A
K
V
L
K
D
K
--
G
--
L
A
--
T
G
--
V
--
G
D
E
G
G
F
A
P
N
L
G
S
N
K
E
A
L
E
L
L
L
T
A
I
E
A
A
G
Y
K
P
G
E
Q
-
V
A
L
A
M
D
V
A
S
S
E
F
Y
K
--
N
G
L
-
Y
T
C
D
-
G
---------------
V
S
H
E
P
----
A
G
M
I
-
G
I
L
-
A
D
L
V
S
Q
Y
P
I
V
S
I
E
D
G
L
Q
E
D
D
W
S
N
W
K
T
L
T
Q
Q
L
--
G
S
T
V
Q
L
V
G
D
D
L
F
-
V
T
N
P
D
R
L
Q
S
G
I
E
Q
G
V
G
N
A
V
L
I
K
L
N
Q
I
G
T
L
T
E
T
L
R
T
I
D
L
A
T
R
S
G
Y
R
S
V
I
S
H
R
S
G
E
T
E
D
T
T
I
A
D
L
A
V
A
T
R
A
G
Q
I
K
T
G
S
L
S
R
S
E
R
I
A
K
Y
N
R
L
L
R
I
E
A
A
L
G
E
N
A
L
Y
A
G
A
---------
30
PsiBlast_CBE
75.24
81%
30
- C1 -
-
5BOE
4
ENO_STAAU
B:
[1-433]
M
P
I
I
T
D
V
Y
A
R
E
V
L
D
S
R
G
N
P
T
V
E
V
E
V
L
T
E
S
G
----------
A
F
G
R
A
L
V
P
S
G
A
S
T
G
E
H
E
A
V
E
L
R
D
G
D
K
S
R
Y
L
G
K
G
V
T
K
A
V
E
N
V
N
E
I
I
A
P
E
I
I
--
E
GE
F
S
V
--
L
D
Q
V
S
I
D
K
M
M
I
A
L
D
G
T
P
N
K
G
K
L
G
A
N
A
I
L
G
V
S
I
A
V
A
R
A
A
A
D
L
L
G
Q
P
L
Y
K
Y
---
L
G
---
G
F
-----
N
---
G
-----
K
-----
Q
L
P
V
P
M
M
N
I
V
N
G
G
S
H
S
D
A
P
I
A
F
Q
E
F
M
I
L
P
V
G
A
T
T
F
K
E
S
L
R
W
G
T
E
I
F
H
N
L
K
S
I
L
S
K
R
--
G
--
L
E
--
T
A
--
V
--
G
D
E
G
G
F
A
P
K
F
E
G
T
E
D
A
V
E
T
I
I
Q
A
I
E
A
A
G
Y
K
P
G
E
E
-
V
F
L
G
F
D
C
A
S
S
E
F
Y
--
E
N
G
V
-
Y
D
Y
S
-
K
F
----
E
----
G
-
E
H
G
A
K
R
T
A
----
A
E
Q
V
-
D
Y
L
-
E
Q
L
V
D
K
Y
P
I
I
T
I
E
D
G
M
D
E
N
D
W
D
G
W
K
Q
L
T
E
R
I
G
D
R
V
Q
L
V
G
---
D
D
L
F
V
T
N
T
E
I
L
A
K
G
I
E
N
G
I
G
N
S
I
L
I
K
V
N
Q
I
G
T
L
T
E
T
F
D
A
I
E
M
A
Q
K
A
G
Y
T
A
V
V
S
H
R
S
G
E
T
E
D
T
T
I
A
D
I
A
V
A
T
N
A
G
Q
I
K
T
G
S
L
S
R
T
D
R
I
A
K
Y
N
Q
L
L
R
I
E
D
E
L
F
E
T
A
K
Y
D
G
I
K
S
F
Y
N
L
D
--
7
PsiBlast_PDB
72.76
81%
30
- C1 -
-
5BOE
3
ENO_STAAU
A:
[1-433]
M
P
I
I
T
D
V
Y
A
R
E
V
L
D
S
R
G
N
P
T
V
E
V
E
V
L
T
E
S
G
----------
A
F
G
R
A
L
V
P
S
G
A
S
T
G
E
H
E
A
V
E
L
R
D
G
D
K
S
R
Y
L
G
K
G
V
T
K
A
V
E
N
V
N
E
I
I
A
P
E
I
I
--
E
G
E
F
S
V
--
L
D
Q
V
S
I
D
K
M
M
I
A
L
D
G
T
P
N
K
G
K
L
G
A
N
A
I
L
G
V
S
I
A
V
A
R
A
A
A
D
L
L
G
Q
P
L
Y
K
Y
---
L
G
---
G
F
-----
N
---
G
-----
K
-----
Q
L
P
V
P
M
M
N
I
V
N
G
G
S
H
S
D
A
P
I
A
F
Q
E
F
M
I
L
P
V
G
A
T
T
F
K
E
S
L
R
W
G
T
E
I
F
H
N
L
K
S
I
L
S
K
R
--
G
--
L
E
--
T
A
--
V
--
G
D
E
G
G
F
A
P
K
F
E
G
T
E
D
A
V
E
T
I
I
Q
A
I
E
A
A
G
Y
K
P
G
E
E
-
V
F
L
G
F
D
C
A
S
S
E
F
Y
--
E
N
G
V
-
Y
D
Y
S
-
K
F
----
E
----
G
-
E
H
G
A
K
R
T
A
----
A
E
Q
V
-
D
Y
L
-
E
Q
L
V
D
K
Y
P
I
I
T
I
E
D
G
M
D
E
N
D
W
D
G
W
K
Q
L
T
E
R
I
G
D
R
V
Q
L
V
G
---
D
D
L
F
V
T
N
T
E
I
L
A
K
G
I
E
N
G
I
G
N
S
I
L
I
K
V
N
Q
I
G
T
L
T
E
T
F
D
A
I
E
M
A
Q
K
A
G
Y
T
A
V
V
S
H
R
S
G
E
T
E
D
T
T
I
A
D
I
A
V
A
T
N
A
G
Q
I
K
T
G
S
L
S
R
T
D
R
I
A
K
Y
N
Q
L
L
R
I
E
D
E
L
F
E
T
A
K
Y
D
G
I
K
S
F
Y
N
L
D
--
19
PsiBlast_PDB
65.95
51%
-0
- C1 -
-
3QTP
1
ENO1_ENTHI
A:
[8-429]
---
I
Q
K
V
H
A
R
E
I
L
D
S
R
G
N
P
T
I
E
V
E
I
T
T
G
K
G
----------
M
F
-
R
S
C
V
P
S
G
A
S
T
G
V
H
E
A
V
E
L
R
D
G
D
K
K
R
Y
G
G
K
G
V
L
K
A
V
E
N
V
N
T
I
I
G
P
A
L
L
--
G
--
K
N
V
--
L
N
Q
A
E
L
D
E
M
M
I
K
L
D
G
T
N
N
K
G
K
L
G
A
N
A
I
L
G
C
S
M
S
I
C
R
A
A
A
A
E
K
G
L
P
L
Y
K
Y
---
L
A
E
L
T
G
H
-----
K
---
E
-----
M
-----
T
M
P
V
P
C
F
N
V
I
N
G
G
A
H
A
G
N
A
L
A
M
Q
E
F
M
I
C
P
T
G
A
T
N
F
H
E
A
L
R
M
A
A
E
T
Y
Q
C
L
K
V
V
I
K
A
K
--
Y
--
G
Q
DA
T
N
--
V
--
G
D
E
G
G
F
A
P
N
V
S
G
A
R
E
A
L
D
L
L
V
E
A
I
A
K
A
G
Y
T
-
G
K
--
I
E
I
A
M
D
C
A
A
S
E
F
Y
N
E
E
T
K
K
-
Y
D
L
G
-
K
K
IPAD
K
----
K
-
D
P
S
L
V
K
D
V
D
G
L
I
A
E
Y
V
-
D
Y
G
-
K
H
----
Y
P
I
A
S
I
E
D
P
F
A
E
D
D
W
A
A
W
N
K
F
T
V
E
H
G
-
N
F
Q
I
V
G
---
D
D
L
L
V
T
N
P
A
R
V
Q
M
A
M
D
K
N
A
C
N
S
V
L
I
K
V
N
Q
I
G
T
L
T
E
T
F
K
T
I
K
M
A
Q
E
K
G
W
G
V
M
A
S
H
R
S
G
E
T
E
D
T
F
I
A
D
L
V
V
G
L
N
C
K
Q
I
K
T
G
A
P
C
R
S
E
R
L
C
K
Y
N
Q
L
M
R
I
E
E
E
L
G
N
I
---------------
52
PsiBlast_CBE
64.56
51%
-3
- C1 -
-
3QTP
1
ENO1_ENTHI
B:
[8-429]
---
I
Q
K
V
H
A
R
E
I
L
D
S
R
G
N
P
T
I
E
V
E
I
T
T
G
K
G
----------
M
F
-
R
S
C
V
P
S
G
A
S
T
G
V
H
E
A
V
E
L
R
D
G
D
K
K
R
Y
G
G
K
G
V
L
K
A
V
E
N
V
N
T
I
I
G
P
A
L
L
--
G
--
K
N
V
--
L
N
Q
A
E
L
D
E
M
M
I
K
L
D
G
T
N
N
K
G
K
L
G
A
N
A
I
L
G
C
S
M
S
I
C
R
A
A
A
A
E
K
G
L
P
L
Y
K
Y
---
L
A
E
L
T
G
H
-----
K
---
E
-----
M
-----
T
M
P
V
P
C
F
N
V
I
N
G
G
A
H
A
G
N
A
L
A
M
Q
E
F
M
I
C
P
T
G
A
T
N
F
H
E
A
L
R
M
A
A
E
T
Y
Q
C
L
K
V
V
I
K
A
K
--
Y
--
G
Q
DA
T
N
--
V
--
G
D
E
G
G
F
A
P
N
V
S
G
A
R
E
A
L
D
L
L
V
E
A
I
A
K
A
G
Y
T
-
G
K
--
I
E
I
A
M
D
C
A
A
S
E
F
Y
N
E
E
T
K
K
-
Y
D
L
G
-
K
K
IPAD
K
----
K
-
D
P
S
L
V
K
D
V
D
G
L
I
A
E
Y
V
-
D
Y
G
-
K
H
----
Y
P
I
A
S
I
E
D
P
F
A
E
D
D
W
A
A
W
N
K
F
T
V
E
H
G
-
N
F
Q
I
V
G
---
D
D
L
L
V
T
N
P
A
R
V
Q
M
A
M
D
K
N
A
C
N
S
V
L
I
K
V
N
Q
I
G
T
L
T
E
T
F
K
T
I
K
M
A
Q
E
K
G
W
G
V
M
A
S
H
R
S
G
E
T
E
D
T
F
I
A
D
L
V
V
G
L
N
C
K
Q
I
K
T
G
A
P
C
R
S
E
R
L
C
K
Y
N
Q
L
M
R
I
E
E
E
L
G
N
I
---------------
77
PsiBlast_CBE
63.71
48%
20
- C1 -
-
3UJR
1
ENOG_HUMAN
B:
[2-429]
---
I
E
K
I
W
A
R
E
I
L
D
S
R
G
N
P
T
V
E
V
D
L
Y
T
A
K
G
----------
L
F
-
R
A
A
V
P
S
G
A
S
T
G
I
Y
E
A
L
E
L
R
D
G
D
K
Q
R
Y
L
G
K
G
V
L
K
A
V
D
H
I
N
S
T
I
A
P
A
L
I
SS
G
--
L
S
V
--
V
E
Q
E
K
L
D
N
L
M
L
E
L
D
G
T
E
N
K
S
K
F
G
A
N
A
I
L
G
V
S
L
A
V
C
K
A
G
A
A
E
R
E
L
P
L
Y
R
H
IAQ
L
A
---
G
N
-----
S
---
D
-----
L
-----
I
L
P
V
P
A
F
N
V
I
N
G
G
S
H
A
G
N
K
L
A
M
Q
E
F
M
I
L
P
V
G
A
E
S
F
R
D
A
M
R
L
G
A
E
V
Y
H
T
L
K
G
V
I
K
D
K
Y-
G
--
K
D
A-
T
N
--
V
--
G
D
E
G
G
F
A
P
N
I
L
E
N
S
E
A
L
E
L
V
K
E
A
I
D
K
A
G
Y
T
--
E
K
-
I
V
I
G
M
D
V
A
A
S
E
F
Y
R
D
G
K
---
Y
D
L
D
-
F
K
----
S
----
P
-
T
D
P
S
R
Y
I
T
----
G
D
Q
L
-
G
A
L
Y
Q
D
F
V
R
D
Y
P
V
V
S
I
E
D
P
F
D
Q
D
D
W
A
A
W
S
K
F
T
A
N
V
G
--
I
Q
I
V
G
---
D
D
L
T
V
T
N
P
K
R
I
E
R
A
V
E
E
K
A
C
N
C
L
L
L
K
V
N
Q
I
G
S
V
T
E
A
I
Q
A
C
K
L
A
Q
E
N
G
W
G
V
M
V
S
H
R
S
G
E
T
E
D
T
F
I
A
D
L
V
V
G
L
C
T
G
Q
I
K
T
G
A
P
C
R
S
E
R
L
A
K
Y
N
Q
L
M
R
I
E
E
E
L
G
D
E
A
R
F
A
G
-
H
N
F
R
N
----
71
PsiBlast_CBE
63.35
48%
20
- C1 -
-
4ZCW
1
ENOG_HUMAN
B:
[3-430]
---
I
E
K
I
W
A
R
E
I
L
D
S
R
G
N
P
T
V
E
V
D
L
Y
T
A
K
G
----------
L
F
-
R
A
A
V
P
S
G
A
S
T
G
I
Y
E
A
L
E
L
R
D
G
D
K
Q
R
Y
L
G
K
G
V
L
K
A
V
D
H
I
N
S
T
I
A
P
A
L
I
SS
G
--
L
S
V
--
V
E
Q
E
K
L
D
N
L
M
L
E
L
D
G
T
E
N
K
S
K
F
G
A
N
A
I
L
G
V
S
L
A
V
C
K
A
G
A
A
E
R
E
L
P
L
Y
R
H
IAQ
L
A
---
G
N
-----
S
---
D
-----
L
-----
I
L
P
V
P
A
F
N
V
I
N
G
G
S
H
A
G
N
K
L
A
M
Q
E
F
M
I
L
P
V
G
A
E
S
F
R
D
A
M
R
L
G
A
E
V
Y
H
T
L
K
G
V
I
K
D
K
Y-
G
--
K
D
A-
T
N
--
V
--
G
D
E
G
G
F
A
P
N
I
L
E
N
S
E
A
L
E
L
V
K
E
A
I
D
K
A
G
Y
T
--
E
K
-
I
V
I
G
M
D
V
A
A
S
E
F
Y
R
D
G
K
---
Y
D
L
D
-
F
K
----
S
----
P
-
T
D
P
S
R
Y
I
T
----
G
D
Q
L
-
G
A
L
Y
Q
D
F
V
R
D
Y
P
V
V
S
I
E
D
P
F
D
Q
D
D
W
A
A
W
S
K
F
T
A
N
V
G
--
I
Q
I
V
G
---
D
D
L
T
V
T
N
P
K
R
I
E
R
A
V
E
E
K
A
C
N
C
L
L
L
K
V
N
Q
I
G
S
V
T
E
A
I
Q
A
C
K
L
A
Q
E
N
G
W
G
V
M
V
S
H
R
S
G
E
T
E
D
T
F
I
A
D
L
V
V
G
L
C
T
G
Q
I
K
T
G
A
P
C
R
S
E
R
L
A
K
Y
N
Q
L
M
R
I
E
E
E
L
G
D
E
A
R
F
A
G
-
H
N
F
R
N
----
163
HHSearch
63.03
50%
21
- C1 -
-
2AL1
1
ENO1_YEAST
A:
[1-435]
--
A
V
S
K
V
Y
A
R
S
V
Y
D
S
R
G
N
P
T
V
E
V
E
L
T
T
E
K
G
----------
V
F
-
R
S
I
V
P
S
G
A
S
T
G
V
H
E
A
L
E
M
R
D
G
D
K
S
K
W
M
G
K
G
V
L
H
A
V
K
N
V
N
D
V
I
A
P
A
F
V
K
A
N
--
I
D
V
--
K
D
Q
K
A
V
D
D
F
L
I
S
L
D
G
T
A
N
K
S
K
L
G
A
N
A
I
L
G
V
S
L
A
A
S
R
A
A
A
A
E
K
N
V
P
L
Y
K
H
---
L
A
---
D
L
-----
S
---
K
SKTSP
Y
-----
V
L
P
V
P
F
L
N
V
L
N
G
G
S
H
A
G
G
A
L
A
L
Q
E
F
M
I
A
P
T
G
A
K
T
F
A
E
A
L
R
I
G
S
E
V
Y
H
N
L
K
S
L
T
K
K
R
--
Y
GA
S
A
--
G
N
--
V
--
G
D
E
G
G
V
A
P
N
I
Q
T
A
E
E
A
L
D
L
I
V
D
A
I
K
A
A
G
H
D
--
G
K
-
V
K
I
G
L
D
C
A
S
S
E
F
F
K
--
D
G
K
-
Y
D
L
D
-
F
K
----
N
P---
N
S
D
K
S
K
W
L
T
G
----
P
Q
L
A
-
D
L
Y
-
H
S
L
M
K
R
Y
P
I
V
S
I
E
D
P
F
A
E
D
D
W
E
A
W
S
H
F
F
K
T
A
--
G
I
Q
I
V
A
---
D
D
L
T
V
T
N
P
K
R
I
A
T
A
I
E
K
K
A
A
D
A
L
L
L
K
V
N
Q
I
G
T
L
S
E
S
I
K
A
A
Q
D
S
F
A
A
G
W
G
V
M
V
S
H
R
S
G
E
T
E
D
T
F
I
A
D
L
V
V
G
L
R
T
G
Q
I
K
T
G
A
P
A
R
S
E
R
L
A
K
L
N
Q
L
L
R
I
E
E
E
L
G
D
N
A
V
F
A
G
E
-
N
F
H
H
G
D
K
-
74
PsiBlast_CBE
63.00
48%
20
- C1 -
-
4ZA0
1
ENOG_HUMAN
A:
[3-430]
---
I
E
K
I
W
A
R
E
I
L
D
S
R
G
N
P
T
V
E
V
D
L
Y
T
A
K
G
----------
L
F
-
R
A
A
V
P
S
G
A
S
T
G
I
Y
E
A
L
E
L
R
D
G
D
K
Q
R
Y
L
G
K
G
V
L
K
A
V
D
H
I
N
S
T
I
A
P
A
L
I
S
S
G
--
L
S
V
--
V
E
Q
E
K
L
D
N
L
M
L
E
L
D
G
T
E
N
K
S
K
F
G
A
N
A
I
L
G
V
S
L
A
V
C
K
A
G
A
A
E
R
E
L
P
L
Y
R
H
I
A
Q
L
A
---
G
N
-----
S
---
D
-----
L
-----
I
L
P
V
P
A
F
N
V
I
N
G
G
S
H
A
G
N
K
L
A
M
Q
E
F
M
I
L
P
V
G
A
E
S
F
R
D
A
M
R
L
G
A
E
V
Y
H
T
L
K
G
V
I
K
D
K
Y-
G
--
K
D
A-
T
N
--
V
--
G
D
E
G
G
F
A
P
N
I
L
E
N
S
E
A
L
E
L
V
K
E
A
I
D
K
A
G
Y
T
--
E
K
-
I
V
I
G
M
D
V
A
A
S
E
F
Y
R
D
G
K
---
Y
D
L
D
-
F
K
----
S
----
P
-
T
D
P
S
R
Y
I
T
----
G
D
Q
L
-
G
A
L
Y
Q
D
F
V
R
D
Y
P
V
V
S
I
E
D
P
F
D
Q
D
D
W
A
A
W
S
K
F
T
A
N
V
G
--
I
Q
I
V
G
---
D
D
L
T
V
T
N
P
K
R
I
E
R
A
V
E
E
K
A
C
N
C
L
L
L
K
V
N
Q
I
G
S
V
T
E
A
I
Q
A
C
K
L
A
Q
E
N
G
W
G
V
M
V
S
H
R
S
G
E
T
E
D
T
F
I
A
D
L
V
V
G
L
C
T
G
Q
I
K
T
G
A
P
C
R
S
E
R
L
A
K
Y
N
Q
L
M
R
I
E
E
E
L
G
D
E
A
R
F
A
G
-
H
N
F
R
N
----
59
PsiBlast_CBE
62.84
48%
20
- C1 -
-
3UCC
1
ENOG_HUMAN
B:
[2-429]
---
I
Q
K
I
W
A
R
E
I
L
D
S
R
G
N
P
T
V
E
V
D
L
Y
T
A
K
G
----------
L
F
-
R
A
A
V
P
S
G
A
S
T
G
I
Y
E
A
L
E
L
R
D
G
D
K
Q
R
Y
L
G
K
G
V
L
K
A
V
D
H
I
N
S
T
I
A
P
A
L
I
SS
G
--
L
S
V
--
V
E
Q
E
K
L
D
N
L
M
L
E
L
D
G
T
E
N
K
S
K
F
G
A
N
A
I
L
G
V
S
L
A
V
C
K
A
G
A
A
E
R
E
L
P
L
Y
R
H
IAQ
L
A
---
G
N
-----
S
---
D
-----
L
-----
I
L
P
V
P
A
F
N
V
I
N
G
G
S
H
A
G
N
K
L
A
M
Q
E
F
M
I
L
P
V
G
A
E
S
F
R
D
A
M
R
L
G
A
E
V
Y
H
T
L
K
G
V
I
K
D
K
Y-
G
--
K
D
A-
T
N
--
V
--
G
D
E
G
G
F
A
P
N
I
L
E
N
S
E
A
L
E
L
V
K
E
A
I
D
K
A
G
Y
T
--
E
K
-
I
V
I
G
M
D
V
A
A
S
E
F
Y
R
D
G
K
---
Y
D
L
D
-
F
K
----
S
----
P
-
T
D
P
S
R
Y
I
T
----
G
D
Q
L
-
G
A
L
Y
Q
D
F
V
R
D
Y
P
V
V
S
I
E
D
P
F
D
Q
D
D
W
A
A
W
S
K
F
T
A
N
V
G
--
I
Q
I
V
G
---
D
D
L
T
V
T
N
P
K
R
I
E
R
A
V
E
E
K
A
C
N
C
L
L
L
K
V
N
Q
I
G
S
V
T
E
A
I
Q
A
C
K
L
A
Q
E
N
G
W
G
V
M
V
S
H
R
S
G
E
T
E
D
T
F
I
A
D
L
V
V
G
L
C
T
G
Q
I
K
T
G
A
P
C
R
S
E
R
L
A
K
Y
N
Q
L
M
R
I
E
E
E
L
G
D
E
A
R
F
A
G
-
H
N
F
R
N
----
73
PsiBlast_CBE
62.80
48%
20
- C1 -
-
4ZA0
1
ENOG_HUMAN
B:
[3-430]
---
I
E
K
I
W
A
R
E
I
L
D
S
R
G
N
P
T
V
E
V
D
L
Y
T
A
K
G
----------
L
F
-
R
A
A
V
P
S
G
A
S
T
G
I
Y
E
A
L
E
L
R
D
G
D
K
Q
R
Y
L
G
K
G
V
L
K
A
V
D
H
I
N
S
T
I
A
P
A
L
I
SS
G
--
L
S
V
--
V
E
Q
E
K
L
D
N
L
M
L
E
L
D
G
T
E
N
K
S
K
F
G
A
N
A
I
L
G
V
S
L
A
V
C
K
A
G
A
A
E
R
E
L
P
L
Y
R
H
IAQ
L
A
---
G
N
-----
S
---
D
-----
L
-----
I
L
P
V
P
A
F
N
V
I
N
G
G
S
H
A
G
N
K
L
A
M
Q
E
F
M
I
L
P
V
G
A
E
S
F
R
D
A
M
R
L
G
A
E
V
Y
H
T
L
K
G
V
I
K
D
K
Y-
G
--
K
D
A-
T
N
--
V
--
G
D
E
G
G
F
A
P
N
I
L
E
N
S
E
A
L
E
L
V
K
E
A
I
D
K
A
G
Y
T
--
E
K
-
I
V
I
G
M
D
V
A
A
S
E
F
Y
R
D
G
K
---
Y
D
L
D
-
F
K
----
S
----
P
-
T
D
P
S
R
Y
I
T
----
G
D
Q
L
-
G
A
L
Y
Q
D
F
V
R
D
Y
P
V
V
S
I
E
D
P
F
D
Q
D
D
W
A
A
W
S
K
F
T
A
N
V
G
--
I
Q
I
V
G
---
D
D
L
T
V
T
N
P
K
R
I
E
R
A
V
E
E
K
A
C
N
C
L
L
L
K
V
N
Q
I
G
S
V
T
E
A
I
Q
A
C
K
L
A
Q
E
N
G
W
G
V
M
V
S
H
R
S
G
E
T
E
D
T
F
I
A
D
L
V
V
G
L
C
T
G
Q
I
K
T
G
A
P
C
R
S
E
R
L
A
K
Y
N
Q
L
M
R
I
E
E
E
L
G
D
E
A
R
F
A
G
-
H
N
F
R
N
----
72
PsiBlast_CBE
62.79
48%
19
- C1 -
-
4ZCW
1
ENOG_HUMAN
A:
[3-430]
---
I
E
K
I
W
A
R
E
I
L
D
S
R
G
N
P
T
V
E
V
D
L
Y
T
A
K
G
----------
L
F
-
R
A
A
V
P
S
G
A
S
T
G
I
Y
E
A
L
E
L
R
D
G
D
K
Q
R
Y
L
G
K
G
V
L
K
A
V
D
H
I
N
S
T
I
A
P
A
L
I
S
S
G
--
L
S
V
--
V
E
Q
E
K
L
D
N
L
M
L
E
L
D
G
T
E
N
K
S
K
F
G
A
N
A
I
L
G
V
S
L
A
V
C
K
A
G
A
A
E
R
E
L
P
L
Y
R
H
I
A
Q
L
A
---
G
N
-----
S
---
D
-----
L
-----
I
L
P
V
P
A
F
N
V
I
N
G
G
S
H
A
G
N
K
L
A
M
Q
E
F
M
I
L
P
V
G
A
E
S
F
R
D
A
M
R
L
G
A
E
V
Y
H
T
L
K
G
V
I
K
D
K
Y-
G
--
K
D
A-
T
N
--
V
--
G
D
E
G
G
F
A
P
N
I
L
E
N
S
E
A
L
E
L
V
K
E
A
I
D
K
A
G
Y
T
--
E
K
-
I
V
I
G
M
D
V
A
A
S
E
F
Y
R
D
G
K
---
Y
D
L
D
-
F
K
----
S
----
P
-
T
D
P
S
R
Y
I
T
----
G
D
Q
L
-
G
A
L
Y
Q
D
F
V
R
D
Y
P
V
V
S
I
E
D
P
F
D
Q
D
D
W
A
A
W
S
K
F
T
A
N
V
G
--
I
Q
I
V
G
---
D
D
L
T
V
T
N
P
K
R
I
E
R
A
V
E
E
K
A
C
N
C
L
L
L
K
V
N
Q
I
G
S
V
T
E
A
I
Q
A
C
K
L
A
Q
E
N
G
W
G
V
M
V
S
H
R
S
G
E
T
E
D
T
F
I
A
D
L
V
V
G
L
C
T
G
Q
I
K
T
G
A
P
C
R
S
E
R
L
A
K
Y
N
Q
L
M
R
I
E
E
E
L
G
D
E
A
R
F
A
G
-
H
N
F
R
N
----
79
PsiBlast_CBE
62.52
48%
19
- C1 -
-
3UJF
1
ENOG_HUMAN
B:
[2-429]
---
I
E
K
I
W
A
R
E
I
L
D
S
R
G
N
P
T
V
E
V
D
L
Y
T
A
K
G
----------
L
F
-
R
A
A
V
P
S
G
A
S
T
G
I
Y
E
A
L
E
L
R
D
G
D
K
Q
R
Y
L
G
K
G
V
L
K
A
V
D
H
I
N
S
T
I
A
P
A
L
I
SS
G
--
L
S
V
--
V
E
Q
E
K
L
D
N
L
M
L
E
L
D
G
T
E
N
K
S
K
F
G
A
N
A
I
L
G
V
S
L
A
V
C
K
A
G
A
A
E
R
E
L
P
L
Y
R
H
IAQ
L
A
---
G
N
-----
S
---
D
-----
L
-----
I
L
P
V
P
A
F
N
V
I
N
G
G
S
H
A
G
N
K
L
A
M
Q
E
F
M
I
L
P
V
G
A
E
S
F
R
D
A
M
R
L
G
A
E
V
Y
H
T
L
K
G
V
I
K
D
K
Y-
G
--
K
D
A-
T
N
--
V
--
G
D
E
G
G
F
A
P
N
I
L
E
N
S
E
A
L
E
L
V
K
E
A
I
D
K
A
G
Y
T
--
E
K
-
I
V
I
G
M
D
V
A
A
S
E
F
Y
R
D
G
K
---
Y
D
L
D
-
F
K
----
S
----
P
-
T
D
P
S
R
Y
I
T
----
G
D
Q
L
-
G
A
L
Y
Q
D
F
V
R
D
Y
P
V
V
S
I
E
D
P
F
D
Q
D
D
W
A
A
W
S
K
F
T
A
N
V
G
--
I
Q
I
V
G
---
D
D
L
T
V
T
N
P
K
R
I
E
R
A
V
E
E
K
A
C
N
C
L
L
L
K
V
N
Q
I
G
S
V
T
E
A
I
Q
A
C
K
L
A
Q
E
N
G
W
G
V
M
V
S
H
R
S
G
E
T
E
D
T
F
I
A
D
L
V
V
G
L
C
T
G
Q
I
K
T
G
A
P
C
R
S
E
R
L
A
K
Y
N
Q
L
M
R
I
E
E
E
L
G
D
E
A
R
F
A
G
-
H
N
F
R
N
----
89
PsiBlast_CBE
62.51
49%
20
- C1 -
-
1PDZ
1
ENO_HOMGA
A:
[3-430]
---
I
T
K
V
F
A
R
T
I
F
D
S
R
G
N
P
T
V
E
V
D
L
Y
T
S
K
G
----------
L
F
-
R
A
A
V
P
S
G
A
S
T
G
V
H
E
A
L
E
M
R
D
G
D
K
S
K
Y
H
G
K
S
V
F
N
A
V
K
N
V
N
D
V
I
V
P
E
I
I
K
S
G
--
L
K
V
--
T
Q
Q
K
E
C
D
E
F
M
C
K
L
D
G
T
E
N
K
S
S
L
G
A
N
A
I
L
G
V
S
L
A
I
C
K
A
G
A
A
E
L
G
I
P
L
Y
R
H
I
A
N
L
A
---
N
Y
-----
D
---
E
-----
V
-----
I
L
P
V
P
A
F
N
V
I
N
G
G
S
H
A
G
N
K
L
A
M
Q
E
F
M
I
L
P
T
G
A
T
S
F
T
E
A
M
R
M
G
T
E
V
Y
H
H
L
K
A
V
I
K
A
R
F-
G
--
L
D
A-
T
A
--
V
--
G
D
E
G
G
F
A
P
N
I
L
N
N
K
D
A
L
D
L
I
Q
E
A
I
K
K
A
G
Y
T
-
G
K
--
I
E
I
G
M
D
V
A
A
S
E
F
Y
-
K
Q
N
N
I
-
Y
D
L
D
F
K
T
----
A
----
N
-
N
D
G
S
Q
K
I
S
----
G
D
Q
L
R
D
M
Y
-
M
E
F
C
K
D
F
P
I
V
S
I
E
D
P
F
D
Q
D
D
W
E
T
W
S
K
M
T
S
--
G
T
T
I
Q
I
V
G
---
D
D
L
T
V
T
N
P
K
R
I
T
T
A
V
E
K
K
A
C
K
C
L
L
L
K
V
N
Q
I
G
S
V
T
E
S
I
D
A
H
L
L
A
K
K
N
G
W
G
T
M
V
S
H
R
S
G
E
T
E
D
C
F
I
A
D
L
V
V
G
L
C
T
G
Q
I
K
T
G
A
P
C
R
S
E
R
L
A
K
Y
N
Q
I
L
R
I
E
E
E
L
G
S
G
A
K
F
A
G
-
K
N
F
------
110
PsiBlast_CBE
62.46
49%
24
- C1 -
-
2AL2
1
ENO1_YEAST
B:
[2-427]
---
V
S
K
V
Y
A
R
S
V
Y
D
S
R
G
N
P
T
V
E
V
E
L
T
T
E
K
G
----------
V
F
-
R
S
I
V
P
S
G
A
-
T
G
V
H
E
A
L
E
M
R
D
G
D
K
S
K
W
M
G
K
G
V
L
H
A
V
K
N
V
N
D
V
I
A
P
A
F
V
--
K
A
D
I
D
V
--
K
D
Q
K
A
V
D
D
F
L
I
S
L
D
G
T
A
N
K
S
K
L
G
A
N
A
I
L
G
V
S
L
A
A
S
R
A
A
A
A
E
K
D
V
P
L
Y
K
H
---
L
A
---
D
L
-----
S
---
K
-----
S
KTSP
Y
V
L
P
V
P
F
L
N
V
L
N
G
G
-----
A
L
A
L
Q
E
F
M
I
A
P
T
G
A
K
T
F
A
E
A
L
R
I
G
S
E
V
Y
H
N
L
K
S
L
T
K
K
R
--
Y
--
G
A
--
S
A
GN
V
--
G
D
E
G
G
V
A
P
N
I
Q
T
A
E
E
A
L
D
L
I
V
D
A
I
K
A
A
G
H
-
D
G
K
--
V
K
I
G
L
D
C
A
S
S
E
F
F
K
D
G
K
Y
D
-
L
D
F
K
-
N
P
----
N
----
S
-
D
K
S
K
W
L
T
G
----
P
Q
L
A
-
D
L
Y
-
H
S
L
M
K
R
Y
P
I
V
S
I
E
D
P
F
A
E
D
D
W
E
A
W
S
H
F
F
K
T
A
G
--
I
Q
I
V
A
---
D
D
L
T
V
T
N
P
K
R
I
A
T
A
I
E
K
K
A
A
D
A
L
L
L
K
V
N
Q
I
G
T
L
S
E
S
I
K
A
A
Q
D
S
F
A
A
G
W
G
V
M
V
S
H
R
S
G
E
T
E
D
T
F
I
A
D
L
V
V
G
L
R
T
G
Q
I
K
T
G
A
P
A
R
S
E
R
L
A
K
L
N
Q
L
L
R
I
E
E
E
L
G
D
N
A
V
F
A
G
----------
75
PsiBlast_CBE
62.40
48%
19
- C1 -
-
3UJS
1
ENOG_HUMAN
B:
[2-429]
---
I
E
K
I
W
A
R
E
I
L
D
S
R
G
N
P
T
V
E
V
D
L
Y
T
A
K
G
----------
L
F
-
R
A
A
V
P
S
G
A
S
T
G
I
Y
E
A
L
E
L
R
D
G
D
K
Q
R
Y
L
G
K
G
V
L
K
A
V
D
H
I
N
S
T
I
A
P
A
L
I
SS
G
--
L
S
V
--
V
E
Q
E
K
L
D
N
L
M
L
E
L
D
G
T
E
N
K
S
K
F
G
A
N
A
I
L
G
V
S
L
A
V
C
K
A
G
A
A
E
R
E
L
P
L
Y
R
H
IAQ
L
A
---
G
N
-----
S
---
D
-----
L
-----
I
L
P
V
P
A
F
N
V
I
N
G
G
S
H
A
G
N
K
L
A
M
Q
E
F
M
I
L
P
V
G
A
E
S
F
R
D
A
M
R
L
G
A
E
V
Y
H
T
L
K
G
V
I
K
D
K
Y-
G
--
K
D
A-
T
N
--
V
--
G
D
E
G
G
F
A
P
N
I
L
E
N
S
E
A
L
E
L
V
K
E
A
I
D
K
A
G
Y
T
--
E
K
-
I
V
I
G
M
D
V
A
A
S
E
F
Y
R
D
G
K
---
Y
D
L
D
-
F
K
----
S
----
P
-
T
D
P
S
R
Y
I
T
----
G
D
Q
L
-
G
A
L
Y
Q
D
F
V
R
D
Y
P
V
V
S
I
E
D
P
F
D
Q
D
D
W
A
A
W
S
K
F
T
A
N
V
G
--
I
Q
I
V
G
---
D
D
L
T
V
T
N
P
K
R
I
E
R
A
V
E
E
K
A
C
N
C
L
L
L
K
V
N
Q
I
G
S
V
T
E
A
I
Q
A
C
K
L
A
Q
E
N
G
W
G
V
M
V
S
H
R
S
G
E
T
E
D
T
F
I
A
D
L
V
V
G
L
C
T
G
Q
I
K
T
G
A
P
C
R
S
E
R
L
A
K
Y
N
Q
L
M
R
I
E
E
E
L
G
D
E
A
R
F
A
G
-
H
N
F
R
N
----
139
PsiBlast_CBE
62.39
49%
28
- C1 -
-
2XH7
1
ENO1_YEAST
A:
[2-427]
---
V
S
K
V
Y
A
R
S
V
Y
D
S
R
G
N
P
T
V
E
V
E
L
T
T
E
K
G
----------
V
F
-
R
S
I
V
P
S
G
A
S
T
G
V
H
E
A
L
E
M
R
D
G
D
K
S
K
W
M
G
K
G
V
L
H
A
V
K
N
V
N
D
V
I
A
P
A
F
V
K
A
N
--
I
D
V
--
K
D
Q
K
A
V
D
D
F
L
I
S
L
D
G
T
A
N
K
S
K
L
G
A
N
A
I
L
G
V
S
L
A
A
S
R
A
A
A
A
E
K
N
V
P
L
Y
K
H
---
L
A
---
D
L
-----
S
---
K
-----
S
KTSP
Y
V
L
P
V
P
F
L
N
V
L
N
G
G
S
H
A
G
G
A
L
A
L
Q
E
F
M
I
A
P
T
G
A
K
T
F
A
E
A
L
R
I
G
S
E
V
Y
H
N
L
K
S
L
T
K
K
R
--
Y
--
G
A
--
S
A
GN
V
--
G
D
E
G
G
V
A
P
N
I
Q
T
A
E
E
A
L
D
L
I
V
D
A
I
K
A
A
G
H
-
D
G
K
--
I
K
I
G
L
D
C
A
S
S
E
F
F
K
D
G
K
Y
D
-
L
D
F
K
-
N
-----
N
----
S
-
D
K
S
K
W
L
T
G
----
P
Q
L
A
-
D
L
Y
-
H
S
L
M
K
R
Y
P
I
V
S
I
E
D
P
F
A
E
D
D
W
E
A
W
S
H
F
F
K
T
A
G
--
I
Q
I
V
A
---
D
A
L
T
V
T
N
P
K
R
I
A
T
A
I
E
K
K
A
A
D
A
L
L
L
K
V
N
Q
I
G
T
L
S
E
S
I
K
A
A
Q
D
S
F
A
A
G
W
G
V
M
V
S
H
R
S
G
E
T
E
D
T
F
I
A
D
L
V
V
G
L
R
T
G
Q
I
K
T
G
A
P
A
R
S
E
R
L
A
K
L
N
Q
L
L
R
I
E
E
E
L
G
D
N
A
V
F
A
G
----------
101
PsiBlast_CBE
62.00
49%
25
- C1 -
-
2ONE
1
ENO1_YEAST
A:
[2-427]
---
V
S
K
V
Y
A
R
S
V
Y
D
S
R
G
N
P
T
V
E
V
E
L
T
T
E
K
G
----------
V
F
-
R
S
I
V
P
S
G
A
S
T
G
V
H
E
A
L
E
M
R
D
G
D
K
S
K
W
M
G
K
G
V
L
H
A
V
K
N
V
N
D
V
I
A
P
A
F
V
K
A
N
--
I
D
V
--
K
D
Q
K
A
V
D
D
F
L
I
S
L
D
G
T
A
N
K
S
K
L
G
A
N
A
I
L
G
V
S
L
A
A
S
R
A
A
A
A
E
K
N
V
P
L
Y
K
H
---
L
A
---
D
L
-----
S
---
K
-----
S
KTSP
Y
V
L
P
V
P
F
L
N
V
L
N
G
G
S
H
A
G
G
A
L
A
L
Q
E
F
M
I
A
P
T
G
A
K
T
F
A
E
A
L
R
I
G
S
E
V
Y
H
N
L
K
S
L
T
K
K
R
--
Y
--
G
A
--
S
A
GN
V
--
G
D
E
G
G
V
A
P
N
I
Q
T
A
E
E
A
L
D
L
I
V
D
A
I
K
A
A
G
H
-
D
G
K
--
V
K
I
G
L
D
C
A
S
S
E
F
F
K
D
G
K
Y
D
-
L
D
F
K
-
N
P
----
N
----
S
-
D
K
S
K
W
L
T
G
----
P
Q
L
A
-
D
L
Y
-
H
S
L
M
K
R
Y
P
I
V
S
I
E
D
P
F
A
E
D
D
W
E
A
W
S
H
F
F
K
T
A
G
--
I
Q
I
V
A
---
D
D
L
T
V
T
N
P
K
R
I
A
T
A
I
E
K
K
A
A
D
A
L
L
L
K
V
N
Q
I
G
T
L
S
E
S
I
K
A
A
Q
D
S
F
A
A
G
W
G
V
M
V
S
H
R
S
G
E
T
E
D
T
F
I
A
D
L
V
V
G
L
R
T
G
Q
I
K
T
G
A
P
A
R
S
E
R
L
A
K
L
N
Q
L
L
R
I
E
E
E
L
G
D
N
A
V
F
A
G
----------
62
PsiBlast_CBE
61.89
48%
18
- C1 -
-
5IDZ
2
ENOG_HUMAN
A:
[3-430]
---
I
E
K
I
W
A
R
E
I
L
D
S
R
G
N
P
T
V
E
V
D
L
Y
T
A
K
G
----------
L
F
-
R
A
A
V
P
S
G
A
S
T
G
I
Y
E
A
L
E
L
R
D
G
D
K
Q
R
Y
L
G
K
G
V
L
K
A
V
D
H
I
N
S
T
I
A
P
A
L
I
S
S
G
--
L
S
V
--
V
E
Q
E
K
L
D
N
L
M
L
E
L
D
G
T
E
N
K
S
K
F
G
A
N
A
I
L
G
V
S
L
A
V
C
K
A
G
A
A
E
R
E
L
P
L
Y
R
H
I
A
Q
L
A
---
G
N
-----
S
---
D
-----
L
-----
I
L
P
V
P
A
F
N
V
I
N
G
G
S
H
A
G
N
K
L
A
M
Q
E
F
M
I
L
P
V
G
A
E
S
F
R
D
A
M
R
L
G
A
E
V
Y
H
T
L
K
G
V
I
K
D
K
Y-
G
--
K
D
A-
T
N
--
V
--
G
D
E
G
G
F
A
P
N
I
L
E
N
S
E
A
L
E
L
V
K
E
A
I
D
K
A
G
Y
T
--
E
K
-
I
V
I
G
M
D
V
A
A
S
E
F
Y
R
D
G
K
---
Y
D
L
D
-
F
K
----
S
----
P
-
T
D
P
S
R
Y
I
T
----
G
D
Q
L
-
G
A
L
Y
Q
D
F
V
R
D
Y
P
V
V
S
I
E
D
P
F
D
Q
D
D
W
A
A
W
S
K
F
T
A
N
V
G
--
I
Q
I
V
G
---
D
D
L
T
V
T
N
P
K
R
I
E
R
A
V
E
E
K
A
C
N
C
L
L
L
K
V
N
Q
I
G
S
V
T
E
A
I
Q
A
C
K
L
A
Q
E
N
G
W
G
V
M
V
S
H
R
S
G
E
T
E
D
T
F
I
A
D
L
V
V
G
L
C
T
G
Q
I
K
T
G
A
P
C
R
S
E
R
L
A
K
Y
N
Q
L
M
R
I
E
E
E
L
G
D
E
A
R
F
A
G
-
H
N
F
R
N
----
57
PsiBlast_CBE
61.82
48%
18
- C1 -
-
3UCD
1
ENOG_HUMAN
B:
[2-429]
---
I
Q
K
I
W
A
R
E
I
L
D
S
R
G
N
P
T
V
E
V
D
L
Y
T
A
K
G
----------
L
F
-
R
A
A
V
P
S
G
A
S
T
G
I
Y
E
A
L
E
L
R
D
G
D
K
Q
R
Y
L
G
K
G
V
L
K
A
V
D
H
I
N
S
T
I
A
P
A
L
I
SS
G
--
L
S
V
--
V
E
Q
E
K
L
D
N
L
M
L
E
L
D
G
T
E
N
K
S
K
F
G
A
N
A
I
L
G
V
S
L
A
V
C
K
A
G
A
A
E
R
E
L
P
L
Y
R
H
IAQ
L
A
---
G
N
-----
S
---
D
-----
L
-----
I
L
P
V
P
A
F
N
V
I
N
G
G
S
H
A
G
N
K
L
A
M
Q
E
F
M
I
L
P
V
G
A
E
S
F
R
D
A
M
R
L
G
A
E
V
Y
H
T
L
K
G
V
I
K
D
K
Y-
G
--
K
D
A-
T
N
--
V
--
G
D
E
G
G
F
A
P
N
I
L
E
N
S
E
A
L
E
L
V
K
E
A
I
D
K
A
G
Y
T
--
E
K
-
I
V
I
G
M
D
V
A
A
S
E
F
Y
R
D
G
K
---
Y
D
L
D
-
F
K
----
S
----
P
-
T
D
P
S
R
Y
I
T
----
G
D
Q
L
-
G
A
L
Y
Q
D
F
V
R
D
Y
P
V
V
S
I
E
D
P
F
D
Q
D
D
W
A
A
W
S
K
F
T
A
N
V
G
--
I
Q
I
V
G
---
D
D
L
T
V
T
N
P
K
R
I
E
R
A
V
E
E
K
A
C
N
C
L
L
L
K
V
N
Q
I
G
S
V
T
E
A
I
Q
A
C
K
L
A
Q
E
N
G
W
G
V
M
V
S
H
R
S
G
E
T
E
D
T
F
I
A
D
L
V
V
G
L
C
T
G
Q
I
K
T
G
A
P
C
R
S
E
R
L
A
K
Y
N
Q
L
M
R
I
E
E
E
L
G
D
E
A
R
F
A
G
-
H
N
F
R
N
----
76
PsiBlast_CBE
61.70
48%
18
- C1 -
-
3UJS
2
ENOG_HUMAN
A:
[2-429]
---
I
E
K
I
W
A
R
E
I
L
D
S
R
G
N
P
T
V
E
V
D
L
Y
T
A
K
G
----------
L
F
-
R
A
A
V
P
S
G
A
S
T
G
I
Y
E
A
L
E
L
R
D
G
D
K
Q
R
Y
L
G
K
G
V
L
K
A
V
D
H
I
N
S
T
I
A
P
A
L
I
S
S
G
--
L
S
V
--
V
E
Q
E
K
L
D
N
L
M
L
E
L
D
G
T
E
N
K
S
K
F
G
A
N
A
I
L
G
V
S
L
A
V
C
K
A
G
A
A
E
R
E
L
P
L
Y
R
H
I
A
Q
L
A
---
G
N
-----
S
---
D
-----
L
-----
I
L
P
V
P
A
F
N
V
I
N
G
G
S
H
A
G
N
K
L
A
M
Q
E
F
M
I
L
P
V
G
A
E
S
F
R
D
A
M
R
L
G
A
E
V
Y
H
T
L
K
G
V
I
K
D
K
Y-
G
--
K
D
A-
T
N
--
V
--
G
D
E
G
G
F
A
P
N
I
L
E
N
S
E
A
L
E
L
V
K
E
A
I
D
K
A
G
Y
T
--
E
K
-
I
V
I
G
M
D
V
A
A
S
E
F
Y
R
D
G
K
---
Y
D
L
D
-
F
K
----
S
----
P
-
T
D
P
S
R
Y
I
T
----
G
D
Q
L
-
G
A
L
Y
Q
D
F
V
R
D
Y
P
V
V
S
I
E
D
P
F
D
Q
D
D
W
A
A
W
S
K
F
T
A
N
V
G
--
I
Q
I
V
G
---
D
D
L
T
V
T
N
P
K
R
I
E
R
A
V
E
E
K
A
C
N
C
L
L
L
K
V
N
Q
I
G
S
V
T
E
A
I
Q
A
C
K
L
A
Q
E
N
G
W
G
V
M
V
S
H
R
S
G
E
T
E
D
T
F
I
A
D
L
V
V
G
L
C
T
G
Q
I
K
T
G
A
P
C
R
S
E
R
L
A
K
Y
N
Q
L
M
R
I
E
E
E
L
G
D
E
A
R
F
A
G
-
H
N
F
R
N
----
82
PsiBlast_CBE
61.62
48%
19
- C1 -
-
3UJE
2
ENOG_HUMAN
A:
[2-429]
---
I
E
K
I
W
A
R
E
I
L
D
S
R
G
N
P
T
V
E
V
D
L
Y
T
A
K
G
----------
L
F
-
R
A
A
V
P
S
G
A
S
T
G
I
Y
E
A
L
E
L
R
D
G
D
K
Q
R
Y
L
G
K
G
V
L
K
A
V
D
H
I
N
S
T
I
A
P
A
L
I
S
S
G
--
L
S
V
--
V
E
Q
E
K
L
D
N
L
M
L
E
L
D
G
T
E
N
K
S
K
F
G
A
N
A
I
L
G
V
S
L
A
V
C
K
A
G
A
A
E
R
E
L
P
L
Y
R
H
I
A
Q
L
A
---
G
N
-----
S
---
D
-----
L
-----
I
L
P
V
P
A
F
N
V
I
N
G
G
S
H
A
G
N
K
L
A
M
Q
E
F
M
I
L
P
V
G
A
E
S
F
R
D
A
M
R
L
G
A
E
V
Y
H
T
L
K
G
V
I
K
D
K
Y-
G
--
K
D
A-
T
N
--
V
--
G
D
E
G
G
F
A
P
N
I
L
E
N
S
E
A
L
E
L
V
K
E
A
I
D
K
A
G
Y
T
--
E
K
-
I
V
I
G
M
D
V
A
A
S
E
F
Y
R
D
G
K
---
Y
D
L
D
-
F
K
----
S
----
P
-
T
D
P
S
R
Y
I
T
----
G
D
Q
L
-
G
A
L
Y
Q
D
F
V
R
D
Y
P
V
V
S
I
E
D
P
F
D
Q
D
D
W
A
A
W
S
K
F
T
A
N
V
G
--
I
Q
I
V
G
---
D
D
L
T
V
T
N
P
K
R
I
E
R
A
V
E
E
K
A
C
N
C
L
L
L
K
V
N
Q
I
G
S
V
T
E
A
I
Q
A
C
K
L
A
Q
E
N
G
W
G
V
M
V
S
H
R
S
G
E
T
E
D
T
F
I
A
D
L
V
V
G
L
C
T
G
Q
I
K
T
G
A
P
C
R
S
E
R
L
A
K
Y
N
Q
L
M
R
I
E
E
E
L
G
D
E
A
R
F
A
G
-
H
N
F
R
N
----
80
PsiBlast_CBE
61.61
48%
22
- C1 -
-
3UJF
1
ENOG_HUMAN
A:
[2-429]
---
I
E
K
I
W
A
R
E
I
L
D
S
R
G
N
P
T
V
E
V
D
L
Y
T
A
K
G
----------
L
F
-
R
A
A
V
P
S
G
A
S
T
G
I
Y
E
A
L
E
L
R
D
G
D
K
Q
R
Y
L
G
K
G
V
L
K
A
V
D
H
I
N
S
T
I
A
P
A
L
I
S
S
G
--
L
S
V
--
V
E
Q
E
K
L
D
N
L
M
L
E
L
D
G
T
E
N
K
S
K
F
G
A
N
A
I
L
G
V
S
L
A
V
C
K
A
G
A
A
E
R
E
L
P
L
Y
R
H
I
A
Q
L
A
---
G
N
-----
S
---
D
-----
L
-----
I
L
P
V
P
A
F
N
V
I
N
G
G
S
H
A
G
N
K
L
A
M
Q
E
F
M
I
L
P
V
G
A
E
S
F
R
D
A
M
R
L
G
A
E
V
Y
H
T
L
K
G
V
I
K
D
K
Y-
G
--
K
D
A-
T
N
--
V
--
G
D
E
G
G
F
A
P
N
I
L
E
N
S
E
A
L
E
L
V
K
E
A
I
D
K
A
G
Y
T
--
E
K
-
I
V
I
G
M
D
V
A
A
S
E
F
Y
R
D
G
K
---
Y
D
L
D
-
F
K
----
S
----
P
-
T
D
P
S
R
Y
I
T
----
G
D
Q
L
-
G
A
L
Y
Q
D
F
V
R
D
Y
P
V
V
S
I
E
D
P
F
D
Q
D
D
W
A
A
W
S
K
F
T
A
N
V
G
--
I
Q
I
V
G
---
D
D
L
T
V
T
N
P
K
R
I
E
R
A
V
E
E
K
A
C
N
C
L
L
L
K
V
N
Q
I
G
S
V
T
E
A
I
Q
A
C
K
L
A
Q
E
N
G
W
G
V
M
V
S
H
R
S
G
E
T
E
D
T
F
I
A
D
L
V
V
G
L
C
T
G
Q
I
K
T
G
A
P
C
R
S
E
R
L
A
K
Y
N
Q
L
M
R
I
E
E
E
L
G
D
E
A
R
F
A
G
-
H
N
F
R
N
----
103
PsiBlast_CBE
61.57
49%
26
- C1 -
-
2AL1
1
ENO1_YEAST
A:
[2-427]
---
V
S
K
V
Y
A
R
S
V
Y
D
S
R
G
N
P
T
V
E
V
E
L
T
T
E
K
G
----------
V
F
-
R
S
I
V
P
S
G
A
S
T
G
V
H
E
A
L
E
M
R
D
G
D
K
S
K
W
M
G
K
G
V
L
H
A
V
K
N
V
N
D
V
I
A
P
A
F
V
K
A
N
--
I
D
V
--
K
D
Q
K
A
V
D
D
F
L
I
S
L
D
G
T
A
N
K
S
K
L
G
A
N
A
I
L
G
V
S
L
A
A
S
R
A
A
A
A
E
K
N
V
P
L
Y
K
H
---
L
A
---
D
L
-----
S
---
K
-----
S
KTSP
Y
V
L
P
V
P
F
L
N
V
L
N
G
G
S
H
A
G
G
A
L
A
L
Q
E
F
M
I
A
P
T
G
A
K
T
F
A
E
A
L
R
I
G
S
E
V
Y
H
N
L
K
S
L
T
K
K
R
--
Y
--
G
A
--
S
A
GN
V
--
G
D
E
G
G
V
A
P
N
I
Q
T
A
E
E
A
L
D
L
I
V
D
A
I
K
A
A
G
H
-
D
G
K
--
V
K
I
G
L
D
C
A
S
S
E
F
F
K
D
G
K
Y
D
-
L
D
F
K
-
N
P
----
N
----
S
-
D
K
S
K
W
L
T
G
----
P
Q
L
A
-
D
L
Y
-
H
S
L
M
K
R
Y
P
I
V
S
I
E
D
P
F
A
E
D
D
W
E
A
W
S
H
F
F
K
T
A
G
--
I
Q
I
V
A
---
D
D
L
T
V
T
N
P
K
R
I
A
T
A
I
E
K
K
A
A
D
A
L
L
L
K
V
N
Q
I
G
T
L
S
E
S
I
K
A
A
Q
D
S
F
A
A
G
W
G
V
M
V
S
H
R
S
G
E
T
E
D
T
F
I
A
D
L
V
V
G
L
R
T
G
Q
I
K
T
G
A
P
A
R
S
E
R
L
A
K
L
N
Q
L
L
R
I
E
E
E
L
G
D
N
A
V
F
A
G
----------
58
PsiBlast_CBE
61.48
48%
18
- C1 -
-
3UCD
1
ENOG_HUMAN
A:
[2-429]
---
I
Q
K
I
W
A
R
E
I
L
D
S
R
G
N
P
T
V
E
V
D
L
Y
T
A
K
G
----------
L
F
-
R
A
A
V
P
S
G
A
S
T
G
I
Y
E
A
L
E
L
R
D
G
D
K
Q
R
Y
L
G
K
G
V
L
K
A
V
D
H
I
N
S
T
I
A
P
A
L
I
S
S
G
--
L
S
V
--
V
E
Q
E
K
L
D
N
L
M
L
E
L
D
G
T
E
N
K
S
K
F
G
A
N
A
I
L
G
V
S
L
A
V
C
K
A
G
A
A
E
R
E
L
P
L
Y
R
H
I
A
Q
L
A
---
G
N
-----
S
---
D
-----
L
-----
I
L
P
V
P
A
F
N
V
I
N
G
G
S
H
A
G
N
K
L
A
M
Q
E
F
M
I
L
P
V
G
A
E
S
F
R
D
A
M
R
L
G
A
E
V
Y
H
T
L
K
G
V
I
K
D
K
Y-
G
--
K
D
A-
T
N
--
V
--
G
D
E
G
G
F
A
P
N
I
L
E
N
S
E
A
L
E
L
V
K
E
A
I
D
K
A
G
Y
T
--
E
K
-
I
V
I
G
M
D
V
A
A
S
E
F
Y
R
D
G
K
---
Y
D
L
D
-
F
K
----
S
----
P
-
T
D
P
S
R
Y
I
T
----
G
D
Q
L
-
G
A
L
Y
Q
D
F
V
R
D
Y
P
V
V
S
I
E
D
P
F
D
Q
D
D
W
A
A
W
S
K
F
T
A
N
V
G
--
I
Q
I
V
G
---
D
D
L
T
V
T
N
P
K
R
I
E
R
A
V
E
E
K
A
C
N
C
L
L
L
K
V
N
Q
I
G
S
V
T
E
A
I
Q
A
C
K
L
A
Q
E
N
G
W
G
V
M
V
S
H
R
S
G
E
T
E
D
T
F
I
A
D
L
V
V
G
L
C
T
G
Q
I
K
T
G
A
P
C
R
S
E
R
L
A
K
Y
N
Q
L
M
R
I
E
E
E
L
G
D
E
A
R
F
A
G
-
H
N
F
R
N
----
117
PsiBlast_CBE
61.41
49%
27
- C1 -
-
5ENL
1
ENO1_YEAST
A:
[2-427]
---
V
S
K
V
Y
A
R
S
V
Y
D
S
R
G
N
P
T
V
E
V
E
L
T
T
E
K
G
----------
V
F
-
R
S
I
V
P
S
G
A
S
T
G
V
H
E
A
L
E
M
R
D
G
D
K
S
K
W
M
G
K
G
V
L
H
A
V
K
N
V
N
D
V
I
A
P
A
F
V
K
A
N
--
I
D
V
--
S
D
Q
K
A
V
D
D
F
L
I
S
L
D
G
T
A
N
K
S
K
L
G
A
N
A
I
L
G
V
S
L
A
A
S
R
A
A
A
A
E
K
N
V
P
L
Y
K
H
---
L
A
---
D
L
-----
S
---
K
-----
S
KTSP
Y
V
L
P
V
P
F
L
N
V
L
N
G
G
S
H
A
G
G
A
L
A
L
Q
E
F
M
I
A
P
T
G
A
K
T
F
A
E
A
L
R
I
G
S
E
V
Y
H
N
L
K
S
L
T
K
K
R
--
Y
--
G
A
--
S
A
GN
V
--
G
D
E
G
G
V
A
P
N
I
Q
T
A
E
E
A
L
D
L
I
V
D
A
I
K
A
A
G
H
-
D
G
K
--
V
K
I
G
L
D
C
A
S
S
E
F
F
K
D
G
K
Y
D
-
L
D
F
K
-
N
P
----
N
----
S
-
D
K
S
K
W
L
T
G
----
P
Q
L
A
-
D
L
Y
-
H
S
L
M
K
R
Y
P
I
V
S
I
E
D
P
F
A
E
D
D
W
E
A
W
S
H
F
F
K
T
A
G
--
I
Q
I
V
A
---
D
D
L
T
V
T
N
P
K
R
I
A
T
A
I
E
K
K
A
A
D
A
L
L
L
K
V
N
Q
I
G
T
L
S
E
S
I
K
A
A
Q
D
S
F
A
A
G
W
G
V
M
V
S
H
R
S
G
E
T
E
D
T
F
I
A
D
L
V
V
G
L
R
T
G
Q
I
K
T
G
A
P
A
R
S
E
R
L
A
K
L
N
Q
L
L
R
I
E
E
E
L
G
D
N
A
V
F
A
G
----------
60
PsiBlast_CBE
61.39
48%
21
- C1 -
-
3UCC
2
ENOG_HUMAN
A:
[2-429]
---
I
Q
K
I
W
A
R
E
I
L
D
S
R
G
N
P
T
V
E
V
D
L
Y
T
A
K
G
----------
L
F
-
R
A
A
V
P
S
G
A
S
T
G
I
Y
E
A
L
E
L
R
D
G
D
K
Q
R
Y
L
G
K
G
V
L
K
A
V
D
H
I
N
S
T
I
A
P
A
L
I
S
S
G
--
L
S
V
--
V
E
Q
E
K
L
D
N
L
M
L
E
L
D
G
T
E
N
K
S
K
F
G
A
N
A
I
L
G
V
S
L
A
V
C
K
A
G
A
A
E
R
E
L
P
L
Y
R
H
I
A
Q
L
A
---
G
N
-----
S
---
D
-----
L
-----
I
L
P
V
P
A
F
N
V
I
N
G
G
S
H
A
G
N
K
L
A
M
Q
E
F
M
I
L
P
V
G
A
E
S
F
R
D
A
M
R
L
G
A
E
V
Y
H
T
L
K
G
V
I
K
D
K
Y-
G
--
K
D
A-
T
N
--
V
--
G
D
E
G
G
F
A
P
N
I
L
E
N
S
E
A
L
E
L
V
K
E
A
I
D
K
A
G
Y
T
--
E
K
-
I
V
I
G
M
D
V
A
A
S
E
F
Y
R
D
G
K
---
Y
D
L
D
-
F
K
----
S
----
P
-
T
D
P
S
R
Y
I
T
----
G
D
Q
L
-
G
A
L
Y
Q
D
F
V
R
D
Y
P
V
V
S
I
E
D
P
F
D
Q
D
D
W
A
A
W
S
K
F
T
A
N
V
G
--
I
Q
I
V
G
---
D
D
L
T
V
T
N
P
K
R
I
E
R
A
V
E
E
K
A
C
N
C
L
L
L
K
V
N
Q
I
G
S
V
T
E
A
I
Q
A
C
K
L
A
Q
E
N
G
W
G
V
M
V
S
H
R
S
G
E
T
E
D
T
F
I
A
D
L
V
V
G
L
C
T
G
Q
I
K
T
G
A
P
C
R
S
E
R
L
A
K
Y
N
Q
L
M
R
I
E
E
E
L
G
D
E
A
R
F
A
G
-
H
N
F
R
N
----
170
HHSearch
61.31
49%
35
- C1 -
-
3QTP
1
ENO1_ENTHI
B:
[5-440]
S
M
S
I
Q
K
V
H
A
R
E
I
L
D
S
R
G
N
P
T
I
E
V
E
I
T
T
G
K
G
M
F
R
S
C
V
P
S
G
A
S
T
G
V
H
E
A
V
E
L
-----------
R
D
G
D
K
K
R
Y
G
G
K
G
V
L
K
A
V
E
N
V
N
T
I
I
G
P
A
L
L
--
G
--
K
N
V
--
L
N
Q
A
E
L
D
E
M
M
I
K
L
D
G
T
N
N
K
G
K
L
G
A
N
A
I
L
G
C
S
M
S
I
C
R
A
A
A
A
E
K
G
L
P
L
Y
K
Y
---
L
A
---
E
L
-----
T
GHK
E
-----
M
-----
T
M
P
V
P
C
F
N
V
I
N
G
G
A
H
A
G
N
A
L
A
M
Q
E
F
M
I
C
P
T
G
A
T
N
F
H
E
A
L
R
M
A
A
E
T
Y
Q
C
L
K
V
V
I
K
A
K
Y-
G
Q-
D
A
--
T
N
--
V
--
G
D
E
G
G
F
A
P
N
V
S
G
A
R
E
A
L
D
L
L
V
E
A
I
A
K
A
G
Y
--
T
G
K
-
I
E
I
A
M
D
C
A
A
S
E
F
Y
N
E
E
T
K
K
-
Y
D
L
G
-
K
K
----
I
PADK
K
-
D
P
S
L
V
K
D
V
----
D
G
L
I
-
A
E
Y
-
V
D
Y
G
K
H
Y
P
I
A
S
I
E
D
P
F
A
E
D
D
W
A
A
W
N
K
F
T
V
E
H
G
-
N
F
Q
I
V
G
---
D
D
L
L
V
T
N
P
A
R
V
Q
M
A
M
D
K
N
A
C
N
S
V
L
I
K
V
N
Q
I
G
T
L
T
E
T
F
K
T
I
K
M
A
Q
E
K
G
W
G
V
M
A
S
H
R
S
G
E
T
E
D
T
F
I
A
D
L
V
V
G
L
N
C
K
Q
I
K
T
G
A
P
C
R
S
E
R
L
C
K
Y
N
Q
L
M
R
I
E
E
E
L
G
N
I
-
P
Y
A
G
K
-
N
W
R
N
S
T
--
61
PsiBlast_CBE
61.26
48%
21
- C1 -
-
5IDZ
2
ENOG_HUMAN
B:
[3-430]
---
I
E
K
I
W
A
R
E
I
L
D
S
R
G
N
P
T
V
E
V
D
L
Y
T
A
K
G
----------
L
F
-
R
A
A
V
P
S
G
A
S
T
G
I
Y
E
A
L
E
L
R
D
G
D
K
Q
R
Y
L
G
K
G
V
L
K
A
V
D
H
I
N
S
T
I
A
P
A
L
I
SS
G
--
L
S
V
--
V
E
Q
E
K
L
D
N
L
M
L
E
L
D
G
T
E
N
K
S
K
F
G
A
N
A
I
L
G
V
S
L
A
V
C
K
A
G
A
A
E
R
E
L
P
L
Y
R
H
IAQ
L
A
---
G
N
-----
S
---
D
-----
L
-----
I
L
P
V
P
A
F
N
V
I
N
G
G
S
H
A
G
N
K
L
A
M
Q
E
F
M
I
L
P
V
G
A
E
S
F
R
D
A
M
R
L
G
A
E
V
Y
H
T
L
K
G
V
I
K
D
K
Y-
G
--
K
D
A-
T
N
--
V
--
G
D
E
G
G
F
A
P
N
I
L
E
N
S
E
A
L
E
L
V
K
E
A
I
D
K
A
G
Y
T
--
E
K
-
I
V
I
G
M
D
V
A
A
S
E
F
Y
R
D
G
K
---
Y
D
L
D
-
F
K
----
S
----
P
-
T
D
P
S
R
Y
I
T
----
G
D
Q
L
-
G
A
L
Y
Q
D
F
V
R
D
Y
P
V
V
S
I
E
D
P
F
D
Q
D
D
W
A
A
W
S
K
F
T
A
N
V
G
--
I
Q
I
V
G
---
D
D
L
T
V
T
N
P
K
R
I
E
R
A
V
E
E
K
A
C
N
C
L
L
L
K
V
N
Q
I
G
S
V
T
E
A
I
Q
A
C
K
L
A
Q
E
N
G
W
G
V
M
V
S
H
R
S
G
E
T
E
D
T
F
I
A
D
L
V
V
G
L
C
T
G
Q
I
K
T
G
A
P
C
R
S
E
R
L
A
K
Y
N
Q
L
M
R
I
E
E
E
L
G
D
E
A
R
F
A
G
-
H
N
F
R
N
----
112
PsiBlast_CBE
61.23
49%
28
- C1 -
-
1P48
1
ENO1_YEAST
A:
[2-427]
---
V
S
K
V
Y
A
R
S
V
Y
D
S
R
G
N
P
T
V
E
V
E
L
T
T
E
K
G
----------
V
F
-
R
S
I
V
P
S
G
A
S
T
G
V
H
E
A
L
E
M
R
D
G
D
K
S
K
W
M
G
K
G
V
L
H
A
V
K
N
V
N
D
V
I
A
P
A
F
V
K
A
N
--
I
D
V
--
K
D
Q
K
A
V
D
D
F
L
I
S
L
D
G
T
A
N
K
S
K
L
G
A
N
A
I
L
G
V
S
L
A
A
S
R
A
A
A
A
E
K
N
V
P
L
Y
K
H
---
L
A
---
D
L
-----
S
---
K
-----
S
KTSP
Y
V
L
P
V
P
F
L
N
V
L
N
G
G
S
H
A
G
G
A
L
A
L
Q
E
F
M
I
A
P
T
G
A
K
T
F
A
E
A
L
R
I
G
S
E
V
Y
H
N
L
K
S
L
T
K
K
R
--
Y
--
G
A
--
S
A
GN
V
--
G
D
Q
G
G
V
A
P
N
I
Q
T
A
E
E
A
L
D
L
I
V
D
A
I
K
A
A
G
H
-
D
G
K
--
V
K
I
G
L
D
C
A
S
S
E
F
F
K
D
G
K
Y
D
-
L
D
F
K
-
N
P
----
N
----
S
-
D
K
S
K
W
L
T
G
----
P
Q
L
A
-
D
L
Y
-
H
S
L
M
K
R
Y
P
I
V
S
I
E
D
P
F
A
E
D
D
W
E
A
W
S
H
F
F
K
T
A
G
--
I
Q
I
V
A
---
D
D
L
T
V
T
N
P
K
R
I
A
T
A
I
E
K
K
A
A
D
A
L
L
L
K
V
N
Q
I
G
T
L
S
E
S
I
K
A
A
Q
D
S
F
A
A
G
W
G
V
M
V
S
H
R
S
G
E
T
E
D
T
F
I
A
D
L
V
V
G
L
R
T
G
Q
I
K
T
G
A
P
A
R
S
E
R
L
A
K
L
N
Q
L
L
R
I
E
E
E
L
G
D
N
A
V
F
A
G
----------
129
PsiBlast_CBE
61.18
49%
26
- C1 -
-
2AL2
1
ENO1_YEAST
A:
[2-427]
---
V
S
K
V
Y
A
R
S
V
Y
D
S
R
G
N
P
T
V
E
V
E
L
T
T
E
K
G
----------
V
F
-
R
S
I
V
P
S
G
A
S
T
G
V
H
E
A
L
E
M
R
D
G
D
K
S
K
W
M
G
K
G
V
L
H
A
V
K
N
V
N
D
V
I
A
P
A
F
V
K
A
N
--
I
D
V
--
K
D
Q
K
A
V
D
D
F
L
I
S
L
D
G
T
A
N
K
S
K
L
G
A
N
A
I
L
G
V
S
L
A
A
S
R
A
A
A
A
E
K
N
V
P
L
Y
K
H
---
L
A
---
D
L
-----
S
---
K
-----
S
KTSP
Y
V
L
P
V
P
F
L
N
V
L
N
G
G
S
H
A
G
G
A
L
A
L
Q
E
F
M
I
A
P
T
G
A
K
T
F
A
E
A
L
R
I
G
S
E
V
Y
H
N
L
K
S
L
T
K
K
R
--
Y
--
G
A
--
S
A
GN
V
--
G
D
E
G
G
V
A
P
N
I
Q
T
A
E
E
A
L
D
L
I
V
D
A
I
K
A
A
G
H
-
D
G
K
--
V
K
I
G
L
D
C
A
S
S
E
F
F
K
D
G
K
Y
D
-
L
D
F
K
-
N
P
----
N
----
S
-
D
K
S
K
W
L
T
G
----
P
Q
L
A
-
D
L
Y
-
H
S
L
M
K
R
Y
P
I
V
S
I
E
D
P
F
A
E
D
D
W
E
A
W
S
H
F
F
K
T
A
G
--
I
Q
I
V
A
---
D
D
L
T
V
T
N
P
K
R
I
A
T
A
I
E
K
K
A
A
D
A
L
L
L
A
V
N
Q
I
G
T
L
S
E
S
I
K
A
A
Q
D
S
F
A
A
G
W
G
V
M
V
S
H
R
S
G
E
T
E
D
T
F
I
A
D
L
V
V
G
L
R
T
G
Q
I
K
T
G
A
P
A
R
S
E
R
L
A
K
L
N
Q
L
L
R
I
E
E
E
L
G
D
N
A
V
F
A
G
----------
81
PsiBlast_CBE
61.09
48%
22
- C1 -
-
3UJE
1
ENOG_HUMAN
B:
[2-429]
---
I
E
K
I
W
A
R
E
I
L
D
S
R
G
N
P
T
V
E
V
D
L
Y
T
A
K
G
----------
L
F
-
R
A
A
V
P
S
G
A
S
T
G
I
Y
E
A
L
E
L
R
D
G
D
K
Q
R
Y
L
G
K
G
V
L
K
A
V
D
H
I
N
S
T
I
A
P
A
L
I
SS
G
--
L
S
V
--
V
E
Q
E
K
L
D
N
L
M
L
E
L
D
G
T
E
N
K
S
K
F
G
A
N
A
I
L
G
V
S
L
A
V
C
K
A
G
A
A
E
R
E
L
P
L
Y
R
H
IAQ
L
A
---
G
N
-----
S
---
D
-----
L
-----
I
L
P
V
P
A
F
N
V
I
N
G
G
S
H
A
G
N
K
L
A
M
Q
E
F
M
I
L
P
V
G
A
E
S
F
R
D
A
M
R
L
G
A
E
V
Y
H
T
L
K
G
V
I
K
D
K
Y-
G
--
K
D
A-
T
N
--
V
--
G
D
E
G
G
F
A
P
N
I
L
E
N
S
E
A
L
E
L
V
K
E
A
I
D
K
A
G
Y
T
--
E
K
-
I
V
I
G
M
D
V
A
A
S
E
F
Y
R
D
G
K
---
Y
D
L
D
-
F
K
----
S
----
P
-
T
D
P
S
R
Y
I
T
----
G
D
Q
L
-
G
A
L
Y
Q
D
F
V
R
D
Y
P
V
V
S
I
E
D
P
F
D
Q
D
D
W
A
A
W
S
K
F
T
A
N
V
G
--
I
Q
I
V
G
---
D
D
L
T
V
T
N
P
K
R
I
E
R
A
V
E
E
K
A
C
N
C
L
L
L
K
V
N
Q
I
G
S
V
T
E
A
I
Q
A
C
K
L
A
Q
E
N
G
W
G
V
M
V
S
H
R
S
G
E
T
E
D
T
F
I
A
D
L
V
V
G
L
C
T
G
Q
I
K
T
G
A
P
C
R
S
E
R
L
A
K
Y
N
Q
L
M
R
I
E
E
E
L
G
D
E
A
R
F
A
G
-
H
N
F
R
N
----
78
PsiBlast_CBE
61.03
48%
21
- C1 -
-
3UJR
2
ENOG_HUMAN
A:
[2-429]
---
I
E
K
I
W
A
R
E
I
L
D
S
R
G
N
P
T
V
E
V
D
L
Y
T
A
K
G
----------
L
F
-
R
A
A
V
P
S
G
A
S
T
G
I
Y
E
A
L
E
L
R
D
G
D
K
Q
R
Y
L
G
K
G
V
L
K
A
V
D
H
I
N
S
T
I
A
P
A
L
I
S
S
G
--
L
S
V
--
V
E
Q
E
K
L
D
N
L
M
L
E
L
D
G
T
E
N
K
S
K
F
G
A
N
A
I
L
G
V
S
L
A
V
C
K
A
G
A
A
E
R
E
L
P
L
Y
R
H
I
A
Q
L
A
---
G
N
-----
S
---
D
-----
L
-----
I
L
P
V
P
A
F
N
V
I
N
G
G
S
H
A
G
N
K
L
A
M
Q
E
F
M
I
L
P
V
G
A
E
S
F
R
D
A
M
R
L
G
A
E
V
Y
H
T
L
K
G
V
I
K
D
K
Y-
G
--
K
D
A-
T
N
--
V
--
G
D
E
G
G
F
A
P
N
I
L
E
N
S
E
A
L
E
L
V
K
E
A
I
D
K
A
G
Y
T
--
E
K
-
I
V
I
G
M
D
V
A
A
S
E
F
Y
R
D
G
K
---
Y
D
L
D
-
F
K
----
S
----
P
-
T
D
P
S
R
Y
I
T
----
G
D
Q
L
-
G
A
L
Y
Q
D
F
V
R
D
Y
P
V
V
S
I
E
D
P
F
D
Q
D
D
W
A
A
W
S
K
F
T
A
N
V
G
--
I
Q
I
V
G
---
D
D
L
T
V
T
N
P
K
R
I
E
R
A
V
E
E
K
A
C
N
C
L
L
L
K
V
N
Q
I
G
S
V
T
E
A
I
Q
A
C
K
L
A
Q
E
N
G
W
G
V
M
V
S
H
R
S
G
E
T
E
D
T
F
I
A
D
L
V
V
G
L
C
T
G
Q
I
K
T
G
A
P
C
R
S
E
R
L
A
K
Y
N
Q
L
M
R
I
E
E
E
L
G
D
E
A
R
F
A
G
-
H
N
F
R
N
----
108
PsiBlast_CBE
60.89
49%
27
- C1 -
-
1EBG
1
ENO1_YEAST
B:
[2-427]
---
V
S
K
V
Y
A
R
S
V
Y
D
S
R
G
N
P
T
V
E
V
E
L
T
T
E
K
G
----------
V
F
-
R
S
I
V
P
S
G
A
S
T
G
V
H
E
A
L
E
M
R
D
G
D
K
S
K
W
M
G
K
G
V
L
H
A
V
K
N
V
N
D
V
I
A
P
A
F
V
KA
N
--
I
D
V
--
K
D
Q
K
A
V
D
D
F
L
I
S
L
D
G
T
A
N
K
S
K
L
G
A
N
A
I
L
G
V
S
L
A
A
S
R
A
A
A
A
E
K
N
V
P
L
Y
K
H
---
L
A
---
D
L
-----
S
---
K
-----
S
KTSPY
V
L
P
V
P
F
L
N
V
L
N
G
G
S
H
A
G
G
A
L
A
L
Q
E
F
M
I
A
P
T
G
A
K
T
F
A
E
A
L
R
I
G
S
E
V
Y
H
N
L
K
S
L
T
K
K
R
--
Y
--
G
A
--
S
A
GN
V
--
G
D
E
G
G
V
A
P
N
I
Q
T
A
E
E
A
L
D
L
I
V
D
A
I
K
A
A
G
H
-
D
G
K
--
V
K
I
G
L
D
C
A
S
S
E
F
F
K
D
G
K
Y
D
-
L
D
F
K
-
N
P
----
N
----
S
-
D
K
S
K
W
L
T
G
----
P
Q
L
A
-
D
L
Y
-
H
S
L
M
K
R
Y
P
I
V
S
I
E
D
P
F
A
E
D
D
W
E
A
W
S
H
F
F
K
T
A
G
--
I
Q
I
V
A
---
D
D
L
T
V
T
N
P
K
R
I
A
T
A
I
E
K
K
A
A
D
A
L
L
L
K
V
N
Q
I
G
T
L
S
E
S
I
K
A
A
Q
D
S
F
A
A
G
W
G
V
M
V
S
H
R
S
G
E
T
E
D
T
F
I
A
D
L
V
V
G
L
R
T
G
Q
I
K
T
G
A
P
A
R
S
E
R
L
A
K
L
N
Q
L
L
R
I
E
E
E
L
G
D
N
A
V
F
A
G
----------
116
PsiBlast_CBE
60.88
49%
28
- C1 -
-
6ENL
1
ENO1_YEAST
A:
[2-427]
---
V
S
K
V
Y
A
R
S
V
Y
D
S
R
G
N
P
T
V
E
V
E
L
T
T
E
K
G
----------
V
F
-
R
S
I
V
P
S
G
A
S
T
G
V
H
E
A
L
E
M
R
D
G
D
K
S
K
W
M
G
K
G
V
L
H
A
V
K
N
V
N
D
V
I
A
P
A
F
V
K
A
N
--
I
D
V
--
S
D
Q
K
A
V
D
D
F
L
I
S
L
D
G
T
A
N
K
S
K
L
G
A
N
A
I
L
G
V
S
L
A
A
S
R
A
A
A
A
E
K
N
V
P
L
Y
K
H
---
L
A
---
D
L
-----
S
---
K
-----
S
KTSP
Y
V
L
P
V
P
F
L
N
V
L
N
G
G
S
H
A
G
G
A
L
A
L
Q
E
F
M
I
A
P
T
G
A
K
T
F
A
E
A
L
R
I
G
S
E
V
Y
H
N
L
K
S
L
T
K
K
R
--
Y
--
G
A
--
S
A
GN
V
--
G
D
E
G
G
V
A
P
N
I
Q
T
A
E
E
A
L
D
L
I
V
D
A
I
K
A
A
G
H
-
D
G
K
--
V
K
I
G
L
D
C
A
S
S
E
F
F
K
D
G
K
Y
D
-
L
D
F
K
-
N
P
----
N
----
S
-
D
K
S
K
W
L
T
G
----
P
Q
L
A
-
D
L
Y
-
H
S
L
M
K
R
Y
P
I
V
S
I
E
D
P
F
A
E
D
D
W
E
A
W
S
H
F
F
K
T
A
G
--
I
Q
I
V
A
---
D
D
L
T
V
T
N
P
K
R
I
A
T
A
I
E
K
K
A
A
D
A
L
L
L
K
V
N
Q
I
G
T
L
S
E
S
I
K
A
A
Q
D
S
F
A
A
G
W
G
V
M
V
S
H
R
S
G
E
T
E
D
T
F
I
A
D
L
V
V
G
L
R
T
G
Q
I
K
T
G
A
P
A
R
S
E
R
L
A
K
L
N
Q
L
L
R
I
E
E
E
L
G
D
N
A
V
F
A
G
----------
102
PsiBlast_CBE
60.86
49%
24
- C1 -
-
2AL1
1
ENO1_YEAST
B:
[2-427]
---
V
S
K
V
Y
A
R
S
V
Y
D
S
R
G
N
P
T
V
E
V
E
L
T
T
E
K
G
----------
V
F
-
R
S
I
V
P
S
G
A
S
T
G
V
H
E
A
L
E
M
R
D
G
D
K
S
K
W
M
G
K
G
V
L
H
A
V
K
N
V
N
D
V
I
A
P
A
F
V
K
A
N
--
I
D
V
--
K
D
Q
K
A
V
D
D
F
L
I
S
L
D
G
T
A
N
K
S
K
L
G
A
N
A
I
L
G
V
S
L
A
A
S
R
A
A
A
A
E
K
N
V
P
L
Y
K
H
---
L
A
---
D
L
-----
S
---
K
-----
S
KTSP
Y
V
L
P
V
P
F
L
N
V
L
N
G
G
-----
A
L
A
L
Q
E
F
M
I
A
P
T
G
A
K
T
F
A
E
A
L
R
I
G
S
E
V
Y
H
N
L
K
S
L
T
K
K
R
--
Y
--
G
A
--
S
A
GN
V
--
G
D
E
G
G
V
A
P
N
I
Q
T
A
E
E
A
L
D
L
I
V
D
A
I
K
A
A
G
H
-
D
G
K
--
V
K
I
G
L
D
C
A
S
S
E
F
F
K
D
G
K
Y
D
-
L
D
F
K
-
N
P
----
N
----
S
-
D
K
S
K
W
L
T
G
----
P
Q
L
A
-
D
L
Y
-
H
S
L
M
K
R
Y
P
I
V
S
I
E
D
P
F
A
E
D
D
W
E
A
W
S
H
F
F
K
T
A
G
--
I
Q
I
V
A
---
D
D
L
T
V
T
N
P
K
R
I
A
T
A
I
E
K
K
A
A
D
A
L
L
L
K
V
N
Q
I
G
T
L
S
E
S
I
K
A
A
Q
D
S
F
A
A
G
W
G
V
M
V
S
H
R
S
G
E
T
E
D
T
F
I
A
D
L
V
V
G
L
R
T
G
Q
I
K
T
G
A
P
A
R
S
E
R
L
A
K
L
N
Q
L
L
R
I
E
E
E
L
G
D
N
A
V
F
A
G
----------
111
PsiBlast_CBE
60.85
49%
28
- C1 -
-
1P48
1
ENO1_YEAST
B:
[2-427]
---
V
S
K
V
Y
A
R
S
V
Y
D
S
R
G
N
P
T
V
E
V
E
L
T
T
E
K
G
----------
V
F
-
R
S
I
V
P
S
G
A
S
T
G
V
H
E
A
L
E
M
R
D
G
D
K
S
K
W
M
G
K
G
V
L
H
A
V
K
N
V
N
D
V
I
A
P
A
F
V
KA
N
--
I
D
V
--
K
D
Q
K
A
V
D
D
F
L
I
S
L
D
G
T
A
N
K
S
K
L
G
A
N
A
I
L
G
V
S
L
A
A
S
R
A
A
A
A
E
K
N
V
P
L
Y
K
H
---
L
A
---
D
L
-----
S
---
K
-----
S
KTSPY
V
L
P
V
P
F
L
N
V
L
N
G
G
S
H
A
G
G
A
L
A
L
Q
E
F
M
I
A
P
T
G
A
K
T
F
A
E
A
L
R
I
G
S
E
V
Y
H
N
L
K
S
L
T
K
K
R
--
Y
--
G
A
--
S
A
GN
V
--
G
D
Q
G
G
V
A
P
N
I
Q
T
A
E
E
A
L
D
L
I
V
D
A
I
K
A
A
G
H
-
D
G
K
--
V
K
I
G
L
D
C
A
S
S
E
F
F
K
D
G
K
Y
D
-
L
D
F
K
-
N
P
----
N
----
S
-
D
K
S
K
W
L
T
G
----
P
Q
L
A
-
D
L
Y
-
H
S
L
M
K
R
Y
P
I
V
S
I
E
D
P
F
A
E
D
D
W
E
A
W
S
H
F
F
K
T
A
G
--
I
Q
I
V
A
---
D
D
L
T
V
T
N
P
K
R
I
A
T
A
I
E
K
K
A
A
D
A
L
L
L
K
V
N
Q
I
G
T
L
S
E
S
I
K
A
A
Q
D
S
F
A
A
G
W
G
V
M
V
S
H
R
S
G
E
T
E
D
T
F
I
A
D
L
V
V
G
L
R
T
G
Q
I
K
T
G
A
P
A
R
S
E
R
L
A
K
L
N
Q
L
L
R
I
E
E
E
L
G
D
N
A
V
F
A
G
----------
138
PsiBlast_CBE
60.76
49%
29
- C1 -
-
2XH7
1
ENO1_YEAST
B:
[2-427]
---
V
S
K
V
Y
A
R
S
V
Y
D
S
R
G
N
P
T
V
E
V
E
L
T
T
E
K
G
----------
V
F
-
R
S
I
V
P
S
G
A
S
T
G
V
H
E
A
L
E
M
R
D
G
D
K
S
K
W
M
G
K
G
V
L
H
A
V
K
N
V
N
D
V
I
A
P
A
F
V
K
A
N
--
I
D
V
--
K
D
Q
K
A
V
D
D
F
L
I
S
L
D
G
T
A
N
K
S
K
L
G
A
N
A
I
L
G
V
S
L
A
A
S
R
A
A
A
A
E
K
N
V
P
L
Y
K
H
---
L
A
---
D
L
-----
S
---
K
-----
S
KTSP
Y
V
L
P
V
P
F
L
N
V
L
N
G
G
S
H
A
G
G
A
L
A
L
Q
E
F
M
I
A
P
T
G
A
K
T
F
A
E
A
L
R
I
G
S
E
V
Y
H
N
L
K
S
L
T
K
K
R
--
Y
--
G
A
--
S
A
GN
V
--
G
D
E
G
G
V
A
P
N
I
Q
T
A
E
E
A
L
D
L
I
V
D
A
I
K
A
A
G
H
-
D
G
K
--
I
K
I
G
L
D
C
A
S
S
E
F
F
K
D
G
K
Y
D
-
L
D
F
K
-
N
P
----
N
----
S
-
D
K
S
K
W
L
T
G
----
P
Q
L
A
-
D
L
Y
-
H
S
L
M
K
R
Y
P
I
V
S
I
E
D
P
F
A
E
D
D
W
E
A
W
S
H
F
F
K
T
A
G
--
I
Q
I
V
A
---
D
A
L
T
V
T
N
P
K
R
I
A
T
A
I
E
K
K
A
A
D
A
L
L
L
K
V
N
Q
I
G
T
L
S
E
S
I
K
A
A
Q
D
S
F
A
A
G
W
G
V
M
V
S
H
R
S
G
E
T
E
D
T
F
I
A
D
L
V
V
G
L
R
T
G
Q
I
K
T
G
A
P
A
R
S
E
R
L
A
K
L
N
Q
L
L
R
I
E
E
E
L
G
D
N
A
V
F
A
G
----------
115
PsiBlast_CBE
60.57
49%
31
- C1 -
-
7ENL
1
ENO1_YEAST
A:
[2-427]
---
V
S
K
V
Y
A
R
S
V
Y
D
S
R
G
N
P
T
V
E
V
E
L
T
T
E
K
G
----------
V
F
-
R
S
I
V
P
S
G
A
S
T
G
V
H
E
A
L
E
M
R
D
G
D
K
S
K
W
M
G
K
G
V
L
H
A
V
K
N
V
N
D
V
I
A
P
A
F
V
K
A
N
--
I
D
V
--
S
D
Q
K
A
V
D
D
F
L
I
S
L
D
G
T
A
N
K
S
K
L
G
A
N
A
I
L
G
V
S
L
A
A
S
R
A
A
A
A
E
K
N
V
P
L
Y
K
H
---
L
A
---
D
L
-----
S
---
K
-----
S
KTSP
Y
V
L
P
V
P
F
L
N
V
L
N
G
G
S
H
A
G
G
A
L
A
L
Q
E
F
M
I
A
P
T
G
A
K
T
F
A
E
A
L
R
I
G
S
E
V
Y
H
N
L
K
S
L
T
K
K
R
--
Y
--
G
A
--
S
A
GN
V
--
G
D
E
G
G
V
A
P
N
I
Q
T
A
E
E
A
L
D
L
I
V
D
A
I
K
A
A
G
H
-
D
G
K
--
V
K
I
G
L
D
C
A
S
S
E
F
F
K
D
G
K
Y
D
-
L
D
F
K
-
N
P
----
N
----
S
-
D
K
S
K
W
L
T
G
----
P
Q
L
A
-
D
L
Y
-
H
S
L
M
K
R
Y
P
I
V
S
I
E
D
P
F
A
E
D
D
W
E
A
W
S
H
F
F
K
T
A
G
--
I
Q
I
V
A
---
D
D
L
T
V
T
N
P
K
R
I
A
T
A
I
E
K
K
A
A
D
A
L
L
L
K
V
N
Q
I
G
T
L
S
E
S
I
K
A
A
Q
D
S
F
A
A
G
W
G
V
M
V
S
H
R
S
G
E
T
E
D
T
F
I
A
D
L
V
V
G
L
R
T
G
Q
I
K
T
G
A
P
A
R
S
E
R
L
A
K
L
N
Q
L
L
R
I
E
E
E
L
G
D
N
A
V
F
A
G
----------
171
HHSearch
60.18
49%
34
- C1 -
-
3QTP
1
ENO1_ENTHI
A:
[5-440]
S
M
S
I
Q
K
V
H
A
R
E
I
L
D
S
R
G
N
P
T
I
E
V
E
I
T
T
G
K
G
M
F
R
S
C
V
P
S
GA
S
T
G
V
H
E
A
V
E
L
-----------
R
D
G
D
K
K
R
Y
G
G
K
G
V
L
K
A
V
E
N
V
N
T
I
I
G
P
A
L
L
--
G
--
K
N
V
--
L
N
Q
A
E
L
D
E
M
M
I
K
L
D
G
T
N
N
K
G
K
L
G
A
N
A
I
L
G
C
S
M
S
I
C
R
A
A
A
A
E
K
G
L
P
L
Y
K
Y
---
L
A
---
E
L
-----
T
GHK
E
-----
M
-----
T
M
P
V
P
C
F
N
V
I
N
G
G
A
H
A
G
N
A
L
A
M
Q
E
F
M
I
C
P
T
G
A
T
N
F
H
E
A
L
R
M
A
A
E
T
Y
Q
C
L
K
V
V
I
K
A
K
Y-
G
Q-
D
A
--
T
N
--
V
--
G
D
E
G
G
F
A
P
N
V
S
G
A
R
E
A
L
D
L
L
V
E
A
I
A
K
A
G
Y
--
T
G
K
-
I
E
I
A
M
D
C
A
A
S
E
F
Y
N
E
E
T
K
K
-
Y
D
L
G
-
K
K
----
I
PADK
K
-
D
P
S
L
V
K
D
V
----
D
G
L
I
-
A
E
Y
-
V
D
Y
G
K
H
Y
P
I
A
S
I
E
D
P
F
A
E
D
D
W
A
A
W
N
K
F
T
V
E
H
G
-
N
F
Q
I
V
G
---
D
D
L
L
V
T
N
P
A
R
V
Q
M
A
M
D
K
N
A
C
N
S
V
L
I
K
V
N
Q
I
G
T
L
T
E
T
F
K
T
I
K
M
A
Q
E
K
G
W
G
V
M
A
S
H
R
S
G
E
T
E
D
T
F
I
A
D
L
V
V
G
L
N
C
K
Q
I
K
T
G
A
P
C
R
S
E
R
L
C
K
Y
N
Q
L
M
R
I
E
E
E
L
G
N
I
-
P
Y
A
G
K
-
N
W
R
N
S
T
--
104
PsiBlast_CBE
60.18
49%
28
- C1 -
-
1ONE
1
ENO1_YEAST
B:
[2-427]
---
V
S
K
V
Y
A
R
S
V
Y
D
S
R
G
N
P
T
V
E
V
E
L
T
T
E
K
G
----------
V
F
-
R
S
I
V
P
S
G
A
S
T
G
V
H
E
A
L
E
M
R
D
G
D
K
S
K
W
M
G
K
G
V
L
H
A
V
K
N
V
N
D
V
I
A
P
A
F
V
KA
N
--
I
D
V
--
K
D
Q
K
A
V
D
D
F
L
I
S
L
D
G
T
A
N
K
S
K
L
G
A
N
A
I
L
G
V
S
L
A
A
S
R
A
A
A
A
E
K
N
V
P
L
Y
K
H
---
L
A
---
D
L
-----
S
---
K
-----
S
KTSPY
V
L
P
V
P
F
L
N
V
L
N
G
G
S
H
A
G
G
A
L
A
L
Q
E
F
M
I
A
P
T
G
A
K
T
F
A
E
A
L
R
I
G
S
E
V
Y
H
N
L
K
S
L
T
K
K
R
--
Y
--
G
A
--
S
A
GN
V
--
G
D
E
G
G
V
A
P
N
I
Q
T
A
E
E
A
L
D
L
I
V
D
A
I
K
A
A
G
H
-
D
G
K
--
V
K
I
G
L
D
C
A
S
S
E
F
F
K
D
G
K
Y
D
-
L
D
F
K
-
N
P
----
N
----
S
-
D
K
S
K
W
L
T
G
----
P
Q
L
A
-
D
L
Y
-
H
S
L
M
K
R
Y
P
I
V
S
I
E
D
P
F
A
E
D
D
W
E
A
W
S
H
F
F
K
T
A
G
--
I
Q
I
V
A
---
D
D
L
T
V
T
N
P
K
R
I
A
T
A
I
E
K
K
A
A
D
A
L
L
L
K
V
N
Q
I
G
T
L
S
E
S
I
K
A
A
Q
D
S
F
A
A
G
W
G
V
M
V
S
H
R
S
G
E
T
E
D
T
F
I
A
D
L
V
V
G
L
R
T
G
Q
I
K
T
G
A
P
A
R
S
E
R
L
A
K
L
N
Q
L
L
R
I
E
E
E
L
G
D
N
A
V
F
A
G
----------
114
PsiBlast_CBE
60.09
49%
27
- C1 -
-
1P43
1
ENO1_YEAST
A:
[2-427]
---
V
S
K
V
Y
A
R
S
V
Y
D
S
R
G
N
P
T
V
E
V
E
L
T
T
E
K
G
----------
V
F
-
R
S
I
V
P
S
G
A
S
T
G
V
H
E
A
L
E
M
R
D
G
D
K
S
K
W
M
G
K
G
V
L
H
A
V
K
N
V
N
D
V
I
A
P
A
F
V
K
A
N
--
I
D
V
--
K
D
Q
K
A
V
D
D
F
L
I
S
L
D
G
T
A
N
K
S
K
L
G
A
N
A
I
L
G
V
S
L
A
A
S
R
A
A
A
A
E
K
N
V
P
L
Y
K
H
---
L
A
---
D
L
-----
S
---
K
-----
S
KTSP
Y
V
L
P
V
P
F
L
N
V
L
N
G
G
S
H
A
G
G
A
L
A
L
Q
Q
F
M
I
A
P
T
G
A
K
T
F
A
E
A
L
R
I
G
S
E
V
Y
H
N
L
K
S
L
T
K
K
R
--
Y
--
G
A
--
S
A
GN
V
--
G
D
E
G
G
V
A
P
N
I
Q
T
A
E
E
A
L
D
L
I
V
D
A
I
K
A
A
G
H
-
D
G
K
--
V
K
I
G
L
D
C
A
S
S
E
F
F
K
D
G
K
Y
D
-
L
D
F
K
-
N
P
----
N
----
S
-
D
K
S
K
W
L
T
G
----
P
Q
L
A
-
D
L
Y
-
H
S
L
M
K
R
Y
P
I
V
S
I
E
D
P
F
A
E
D
D
W
E
A
W
S
H
F
F
K
T
A
G
--
I
Q
I
V
A
---
D
D
L
T
V
T
N
P
K
R
I
A
T
A
I
E
K
K
A
A
D
A
L
L
L
K
V
N
Q
I
G
T
L
S
E
S
I
K
A
A
Q
D
S
F
A
A
G
W
G
V
M
V
S
H
R
S
G
E
T
E
D
T
F
I
A
D
L
V
V
G
L
R
T
G
Q
I
K
T
G
A
P
A
R
S
E
R
L
A
K
L
N
Q
L
L
R
I
E
E
E
L
G
D
N
A
V
F
A
G
----------
121
PsiBlast_CBE
60.05
49%
29
- C1 -
-
1ELS
1
ENO1_YEAST
A:
[2-427]
---
V
S
K
V
Y
A
R
S
V
Y
D
S
R
G
N
P
T
V
E
V
E
L
T
T
E
K
G
----------
V
F
-
R
S
I
V
P
S
G
A
S
T
G
V
H
E
A
L
E
M
R
D
G
D
K
S
K
W
M
G
K
G
V
L
H
A
V
K
N
V
N
D
V
I
A
P
A
F
V
K
A
N
--
I
D
V
--
S
D
Q
K
A
V
D
D
F
L
I
S
L
D
G
T
A
N
K
S
K
L
G
A
N
A
I
L
G
V
S
L
A
A
S
R
A
A
A
A
E
K
N
V
P
L
Y
K
H
---
L
A
---
D
L
-----
S
---
K
-----
S
KTSP
Y
V
L
P
V
P
F
L
N
V
L
N
G
G
S
H
A
G
G
A
L
A
L
Q
E
F
M
I
A
P
T
G
A
K
T
F
A
E
A
L
R
I
G
S
E
V
Y
H
N
L
K
S
L
T
K
K
R
--
Y
--
G
A
--
S
A
GN
V
--
G
D
E
G
G
V
A
P
N
I
Q
T
A
E
E
A
L
D
L
I
V
D
A
I
K
A
A
G
H
-
D
G
K
--
V
K
I
G
L
D
C
A
S
S
E
F
F
K
D
G
K
Y
D
-
L
D
F
K
-
N
P
----
N
----
S
-
D
K
S
K
W
L
T
G
----
P
Q
L
A
-
D
L
Y
-
H
S
L
M
K
R
Y
P
I
V
S
I
E
D
P
F
A
E
D
D
W
E
A
W
S
H
F
F
K
T
A
G
--
I
Q
I
V
A
---
D
D
L
T
V
T
N
P
K
R
I
A
T
A
I
E
K
K
A
A
D
A
L
L
L
K
V
N
Q
I
G
T
L
S
E
S
I
K
A
A
Q
D
S
F
A
A
G
W
G
V
M
V
S
H
R
S
G
E
T
E
D
T
F
I
A
D
L
V
V
G
L
R
T
G
Q
I
K
T
G
A
P
A
R
S
E
R
L
A
K
L
N
Q
L
L
R
I
E
E
E
L
G
D
N
A
V
F
A
G
----------
109
PsiBlast_CBE
59.78
49%
29
- C1 -
-
1EBG
1
ENO1_YEAST
A:
[2-427]
---
V
S
K
V
Y
A
R
S
V
Y
D
S
R
G
N
P
T
V
E
V
E
L
T
T
E
K
G
----------
V
F
-
R
S
I
V
P
S
G
A
S
T
G
V
H
E
A
L
E
M
R
D
G
D
K
S
K
W
M
G
K
G
V
L
H
A
V
K
N
V
N
D
V
I
A
P
A
F
V
K
A
N
--
I
D
V
--
K
D
Q
K
A
V
D
D
F
L
I
S
L
D
G
T
A
N
K
S
K
L
G
A
N
A
I
L
G
V
S
L
A
A
S
R
A
A
A
A
E
K
N
V
P
L
Y
K
H
---
L
A
---
D
L
-----
S
---
K
-----
S
KTSP
Y
V
L
P
V
P
F
L
N
V
L
N
G
G
S
H
A
G
G
A
L
A
L
Q
E
F
M
I
A
P
T
G
A
K
T
F
A
E
A
L
R
I
G
S
E
V
Y
H
N
L
K
S
L
T
K
K
R
--
Y
--
G
A
--
S
A
GN
V
--
G
D
E
G
G
V
A
P
N
I
Q
T
A
E
E
A
L
D
L
I
V
D
A
I
K
A
A
G
H
-
D
G
K
--
V
K
I
G
L
D
C
A
S
S
E
F
F
K
D
G
K
Y
D
-
L
D
F
K
-
N
P
----
N
----
S
-
D
K
S
K
W
L
T
G
----
P
Q
L
A
-
D
L
Y
-
H
S
L
M
K
R
Y
P
I
V
S
I
E
D
P
F
A
E
D
D
W
E
A
W
S
H
F
F
K
T
A
G
--
I
Q
I
V
A
---
D
D
L
T
V
T
N
P
K
R
I
A
T
A
I
E
K
K
A
A
D
A
L
L
L
K
V
N
Q
I
G
T
L
S
E
S
I
K
A
A
Q
D
S
F
A
A
G
W
G
V
M
V
S
H
R
S
G
E
T
E
D
T
F
I
A
D
L
V
V
G
L
R
T
G
Q
I
K
T
G
A
P
A
R
S
E
R
L
A
K
L
N
Q
L
L
R
I
E
E
E
L
G
D
N
A
V
F
A
G
----------
105
PsiBlast_CBE
59.66
49%
27
- C1 -
-
1ONE
1
ENO1_YEAST
A:
[2-427]
---
V
S
K
V
Y
A
R
S
V
Y
D
S
R
G
N
P
T
V
E
V
E
L
T
T
E
K
G
----------
V
F
-
R
S
I
V
P
S
G
A
S
T
G
V
H
E
A
L
E
M
R
D
G
D
K
S
K
W
M
G
K
G
V
L
H
A
V
K
N
V
N
D
V
I
A
P
A
F
V
K
A
N
--
I
D
V
--
K
D
Q
K
A
V
D
D
F
L
I
S
L
D
G
T
A
N
K
S
K
L
G
A
N
A
I
L
G
V
S
L
A
A
S
R
A
A
A
A
E
K
N
V
P
L
Y
K
H
---
L
A
---
D
L
-----
S
---
K
-----
S
KTSP
Y
V
L
P
V
P
F
L
N
V
L
N
G
G
S
H
A
G
G
A
L
A
L
Q
E
F
M
I
A
P
T
G
A
K
T
F
A
E
A
L
R
I
G
S
E
V
Y
H
N
L
K
S
L
T
K
K
R
--
Y
--
G
A
--
S
A
GN
V
--
G
D
E
G
G
V
A
P
N
I
Q
T
A
E
E
A
L
D
L
I
V
D
A
I
K
A
A
G
H
-
D
G
K
--
V
K
I
G
L
D
C
A
S
S
E
F
F
K
D
G
K
Y
D
-
L
D
F
K
-
N
P
----
N
----
S
-
D
K
S
K
W
L
T
G
----
P
Q
L
A
-
D
L
Y
-
H
S
L
M
K
R
Y
P
I
V
S
I
E
D
P
F
A
E
D
D
W
E
A
W
S
H
F
F
K
T
A
G
--
I
Q
I
V
A
---
D
D
L
T
V
T
N
P
K
R
I
A
T
A
I
E
K
K
A
A
D
A
L
L
L
K
V
N
Q
I
G
T
L
S
E
S
I
K
A
A
Q
D
S
F
A
A
G
W
G
V
M
V
S
H
R
S
G
E
T
E
D
T
F
I
A
D
L
V
V
G
L
R
T
G
Q
I
K
T
G
A
P
A
R
S
E
R
L
A
K
L
N
Q
L
L
R
I
E
E
E
L
G
D
N
A
V
F
A
G
----------
113
PsiBlast_CBE
59.41
49%
27
- C1 -
-
1P43
1
ENO1_YEAST
B:
[2-427]
---
V
S
K
V
Y
A
R
S
V
Y
D
S
R
G
N
P
T
V
E
V
E
L
T
T
E
K
G
----------
V
F
-
R
S
I
V
P
S
G
A
S
T
G
V
H
E
A
L
E
M
R
D
G
D
K
S
K
W
M
G
K
G
V
L
H
A
V
K
N
V
N
D
V
I
A
P
A
F
V
KA
N
--
I
D
V
--
K
D
Q
K
A
V
D
D
F
L
I
S
L
D
G
T
A
N
K
S
K
L
G
A
N
A
I
L
G
V
S
L
A
A
S
R
A
A
A
A
E
K
N
V
P
L
Y
K
H
---
L
A
---
D
L
-----
S
---
K
-----
S
KTSPY
V
L
P
V
P
F
L
N
V
L
N
G
G
S
H
A
G
G
A
L
A
L
Q
Q
F
M
I
A
P
T
G
A
K
T
F
A
E
A
L
R
I
G
S
E
V
Y
H
N
L
K
S
L
T
K
K
R
--
Y
--
G
A
--
S
A
GN
V
--
G
D
E
G
G
V
A
P
N
I
Q
T
A
E
E
A
L
D
L
I
V
D
A
I
K
A
A
G
H
-
D
G
K
--
V
K
I
G
L
D
C
A
S
S
E
F
F
K
D
G
K
Y
D
-
L
D
F
K
-
N
P
----
N
----
S
-
D
K
S
K
W
L
T
G
----
P
Q
L
A
-
D
L
Y
-
H
S
L
M
K
R
Y
P
I
V
S
I
E
D
P
F
A
E
D
D
W
E
A
W
S
H
F
F
K
T
A
G
--
I
Q
I
V
A
---
D
D
L
T
V
T
N
P
K
R
I
A
T
A
I
E
K
K
A
A
D
A
L
L
L
K
V
N
Q
I
G
T
L
S
E
S
I
K
A
A
Q
D
S
F
A
A
G
W
G
V
M
V
S
H
R
S
G
E
T
E
D
T
F
I
A
D
L
V
V
G
L
R
T
G
Q
I
K
T
G
A
P
A
R
S
E
R
L
A
K
L
N
Q
L
L
R
I
E
E
E
L
G
D
N
A
V
F
A
G
----------
145
Fugue
59.30
49%
28
- C1 -
-
1ONE
1
ENO1_YEAST
A:
[1-436]
--
A
V
S
K
V
Y
A
R
S
V
Y
D
S
R
G
N
P
T
V
E
V
E
L
T
T
E
K
G
-----------
V
F
R
S
I
V
P
S
G
A
S
T
G
V
H
E
A
L
E
M
R
D
G
D
K
S
K
W
M
G
K
G
V
L
H
A
V
K
N
V
N
D
V
I
A
P
A
F
V
--
K
A
N
I
D
V
--
K
D
Q
K
A
V
D
D
F
L
I
S
L
D
G
T
A
N
K
S
K
L
G
A
N
A
I
L
G
V
S
L
A
A
S
R
A
A
A
A
E
K
N
V
P
L
Y
K
H
---
L
A
---
D
L
S
KSKT
S
---
P
-----
Y
-----
V
L
P
V
P
F
L
N
V
L
N
G
G
S
H
A
G
G
A
L
A
L
Q
E
F
M
I
A
P
T
G
A
K
T
F
A
E
A
L
R
I
G
S
E
V
Y
H
N
L
K
S
L
T
K
K
R
YG
A
--
S
A
--
G
N
--
V
--
G
D
E
G
G
V
A
P
N
I
Q
T
A
E
E
A
L
D
L
I
V
D
A
I
K
A
A
G
H
--
D
G
K
-
V
K
I
G
L
D
C
A
S
S
E
F
F
K
D
-
G
K
Y
D
L
D
F
K
-
N
P
----
N
----
S
-
D
K
S
K
W
L
T
G
----
P
Q
L
A
-
D
L
Y
-
H
S
L
M
K
R
Y
P
I
V
S
I
E
D
P
F
A
E
D
D
W
E
A
W
S
H
F
F
K
T
--
A
G
I
Q
I
V
A
---
D
D
L
T
V
T
N
P
K
R
I
A
T
A
I
E
K
K
A
A
D
A
L
L
L
K
V
N
Q
I
G
T
L
S
E
S
I
K
A
A
Q
D
S
F
A
A
G
W
G
V
M
V
S
H
R
S
G
E
T
E
D
T
F
I
A
D
L
V
V
G
L
R
T
G
Q
I
K
T
G
A
P
A
R
S
E
R
L
A
K
L
N
Q
L
L
R
I
E
E
E
L
G
D
N
A
V
F
A
G
-
E
N
F
H
H
G
D
K
L
132
PsiBlast_CBE
59.29
50%
21
- C1 -
-
2PTZ
2
?
A:
[6-426]
---
I
Q
K
V
H
G
R
E
V
L
D
S
R
G
N
P
T
V
E
V
E
V
T
T
E
K
G
----------
V
F
-
R
S
A
V
P
S
G
A
S
T
G
V
Y
E
A
C
E
L
R
D
G
D
K
K
R
Y
V
G
K
G
C
L
Q
A
V
K
N
V
N
E
V
I
G
P
A
L
I
--
G
--
R
D
E
--
L
K
Q
E
E
L
D
T
L
M
L
R
L
D
G
T
P
N
K
G
K
L
G
A
N
A
I
L
G
C
S
M
A
I
S
K
A
A
A
A
A
K
G
V
P
L
Y
R
Y
---
L
A
S
L
A
G
T
-----
K
---
E
-----
L
-----
R
L
P
V
P
C
F
N
V
I
N
G
G
K
H
A
G
N
A
L
P
F
Q
E
F
M
I
A
P
V
K
A
T
S
F
S
E
A
L
R
M
G
S
E
V
Y
H
S
L
R
G
I
I
K
K
K
--
Y
--
G
Q
--
D
A
--
V
NV
G
D
E
G
G
F
A
P
P
I
K
D
I
N
E
P
L
P
I
L
M
E
A
I
E
E
A
G
H
R
-
G
K
--
F
A
I
C
M
D
C
A
A
S
E
T
Y
D
E
K
K
Q
Q
-
Y
N
L
T
-
F
K
----
S
----
P
-
E
P
T
W
V
--
T
----
A
E
Q
L
R
E
T
Y
-
C
K
W
A
H
D
Y
P
I
V
S
I
E
D
P
Y
D
Q
D
D
F
A
G
F
A
G
I
T
E
A
L
K
G
K
T
Q
I
V
G
---
D
D
L
T
V
T
N
T
E
R
I
K
M
A
I
E
K
K
A
C
N
S
L
L
L
K
I
N
Q
I
G
T
I
S
E
A
I
A
S
S
K
L
C
M
E
N
G
W
S
V
M
V
S
H
R
S
G
E
T
E
D
T
Y
I
A
D
L
V
V
A
L
G
S
G
Q
I
K
T
G
A
P
C
R
G
E
R
T
A
K
L
N
Q
L
L
R
I
E
E
E
L
G
A
H
A
K
F
------------
131
PsiBlast_CBE
58.68
50%
20
- C1 -
-
2PU0
4
?
A:
[6-426]
---
I
Q
K
V
H
G
R
E
V
L
D
S
R
G
N
P
T
V
E
V
E
V
T
T
E
K
G
----------
V
F
-
R
S
A
V
P
S
G
A
S
T
G
V
Y
E
A
C
E
L
R
D
G
D
K
K
R
Y
V
G
K
G
C
L
Q
A
V
K
N
V
N
E
V
I
G
P
A
L
I
--
G
--
R
D
E
--
L
K
Q
E
E
L
D
T
L
M
L
R
L
D
G
T
P
N
K
G
K
L
G
A
N
A
I
L
G
C
S
M
A
I
S
K
A
A
A
A
A
K
G
V
P
L
Y
R
Y
---
L
A
S
L
A
G
T
-----
K
---
E
-----
L
-----
R
L
P
V
P
C
F
N
V
I
N
G
G
K
H
A
G
N
A
L
P
F
Q
E
F
M
I
A
P
V
K
A
T
S
F
S
E
A
L
R
M
G
S
E
V
Y
H
S
L
R
G
I
I
K
K
K
--
Y
--
G
Q
--
D
A
--
V
NV
G
D
E
G
G
F
A
P
P
I
K
D
I
N
E
P
L
P
I
L
M
E
A
I
E
E
A
G
H
R
-
G
K
--
F
A
I
C
M
D
C
A
A
S
E
T
Y
D
E
K
K
Q
Q
-
Y
N
L
T
-
F
K
----
S
----
P
-
E
P
T
W
V
--
T
----
A
E
Q
L
R
E
T
Y
-
C
K
W
A
H
D
Y
P
I
V
S
I
E
D
P
Y
D
Q
D
D
F
A
G
F
A
G
I
T
E
A
L
K
G
K
T
Q
I
V
G
---
D
D
L
T
V
T
N
T
E
R
I
K
M
A
I
E
K
K
A
C
N
S
L
L
L
K
I
N
Q
I
G
T
I
S
E
A
I
A
S
S
K
L
C
M
E
N
G
W
S
V
M
V
S
H
R
S
G
E
T
E
D
T
Y
I
A
D
L
V
V
A
L
G
S
G
Q
I
K
T
G
A
P
C
R
G
E
R
T
A
K
L
N
Q
L
L
R
I
E
E
E
L
G
A
H
A
K
F
------------
133
PsiBlast_CBE
58.53
50%
22
- C1 -
-
2PTY
2
?
A:
[6-426]
---
I
Q
K
V
H
G
R
E
V
L
D
S
R
G
N
P
T
V
E
V
E
V
T
T
E
K
G
----------
V
F
-
R
S
A
V
P
S
G
A
S
T
G
V
Y
E
A
C
E
L
R
D
G
D
K
K
R
Y
V
G
K
G
C
L
Q
A
V
K
N
V
N
E
V
I
G
P
A
L
I
--
G
--
R
D
E
--
L
K
Q
E
E
L
D
T
L
M
L
R
L
D
G
T
P
N
K
G
K
L
G
A
N
A
I
L
G
C
S
M
A
I
S
K
A
A
A
A
A
K
G
V
P
L
Y
R
Y
---
L
A
S
L
A
G
T
-----
K
---
E
-----
L
-----
R
L
P
V
P
C
F
N
V
I
N
G
G
K
H
A
G
N
A
L
P
F
Q
E
F
M
I
A
P
V
K
A
T
S
F
S
E
A
L
R
M
G
S
E
V
Y
H
S
L
R
G
I
I
K
K
K
--
Y
--
G
Q
--
D
A
--
V
NV
G
D
E
G
G
F
A
P
P
I
K
D
I
N
E
P
L
P
I
L
M
E
A
I
E
E
A
G
H
R
-
G
K
--
F
A
I
C
M
D
C
A
A
S
E
T
Y
D
E
K
K
Q
Q
-
Y
N
L
T
-
F
K
----
S
----
P
-
E
P
T
W
V
--
T
----
A
E
Q
L
R
E
T
Y
-
C
K
W
A
H
D
Y
P
I
V
S
I
E
D
P
Y
D
Q
D
D
F
A
G
F
A
G
I
T
E
A
L
K
G
K
T
Q
I
V
G
---
D
D
L
T
V
T
N
T
E
R
I
K
M
A
I
E
K
K
A
C
N
S
L
L
L
K
I
N
Q
I
G
T
I
S
E
A
I
A
S
S
K
L
C
M
E
N
G
W
S
V
M
V
S
H
R
S
G
E
T
E
D
T
Y
I
A
D
L
V
V
A
L
G
S
G
Q
I
K
T
G
A
P
C
R
G
E
R
T
A
K
L
N
Q
L
L
R
I
E
E
E
L
G
A
H
A
K
F
------------
130
PsiBlast_CBE
58.53
50%
20
- C1 -
-
2PU1
2
?
A:
[6-426]
---
I
Q
K
V
H
G
R
E
V
L
D
S
R
G
N
P
T
V
E
V
E
V
T
T
E
K
G
----------
V
F
-
R
S
A
V
P
S
G
A
S
T
G
V
Y
E
A
C
E
L
R
D
G
D
K
K
R
Y
V
G
K
G
C
L
Q
A
V
K
N
V
N
E
V
I
G
P
A
L
I
--
G
--
R
D
E
--
L
K
Q
E
E
L
D
T
L
M
L
R
L
D
G
T
P
N
K
G
K
L
G
A
N
A
I
L
G
C
S
M
A
I
S
K
A
A
A
A
A
K
G
V
P
L
Y
R
Y
---
L
A
S
L
A
G
T
-----
K
---
E
-----
L
-----
R
L
P
V
P
C
F
N
V
I
N
G
G
K
H
A
G
N
A
L
P
F
Q
E
F
M
I
A
P
V
K
A
T
S
F
S
E
A
L
R
M
G
S
E
V
Y
H
S
L
R
G
I
I
K
K
K
--
Y
--
G
Q
--
D
A
--
V
NV
G
D
E
G
G
F
A
P
P
I
K
D
I
N
E
P
L
P
I
L
M
E
A
I
E
E
A
G
H
R
-
G
K
--
F
A
I
C
M
D
C
A
A
S
E
T
Y
D
E
K
K
Q
Q
-
Y
N
L
T
-
F
K
----
S
----
P
-
E
P
T
W
V
--
T
----
A
E
Q
L
R
E
T
Y
-
C
K
W
A
H
D
Y
P
I
V
S
I
E
D
P
Y
D
Q
D
D
F
A
G
F
A
G
I
T
E
A
L
K
G
K
T
Q
I
V
G
---
D
D
L
T
V
T
N
T
E
R
I
K
M
A
I
E
K
K
A
C
N
S
L
L
L
K
I
N
Q
I
G
T
I
S
E
A
I
A
S
S
K
L
C
M
E
N
G
W
S
V
M
V
S
H
R
S
G
E
T
E
D
T
Y
I
A
D
L
V
V
A
L
G
S
G
Q
I
K
T
G
A
P
C
R
G
E
R
T
A
K
L
N
Q
L
L
R
I
E
E
E
L
G
A
H
A
K
F
------------
100
PsiBlast_CBE
58.03
49%
30
- C1 -
-
2ONE
1
ENO1_YEAST
B:
[2-427]
---
V
S
K
V
Y
A
R
S
V
Y
D
S
R
G
N
P
T
V
E
V
E
L
T
T
E
K
G
----------
V
F
-
R
S
I
V
P
S
G
A
S
T
G
V
H
E
A
L
E
M
R
D
G
D
K
S
K
W
M
G
K
G
V
L
H
A
V
K
N
V
N
D
V
I
A
P
A
F
V
KA
N
--
I
D
V
--
K
D
Q
K
A
V
D
D
F
L
I
S
L
D
G
T
A
N
K
S
K
L
G
A
N
A
I
L
G
V
S
L
A
A
S
R
A
A
A
A
E
K
N
V
P
L
Y
K
H
---
L
A
---
D
L
-----
S
---
K
-----
S
KTSPY
V
L
P
V
P
F
L
N
V
L
N
G
G
S
H
A
G
G
A
L
A
L
Q
E
F
M
I
A
P
T
G
A
K
T
F
A
E
A
L
R
I
G
S
E
V
Y
H
N
L
K
S
L
T
K
K
R
--
Y
--
G
A
--
S
A
GN
V
--
G
D
E
G
G
V
A
P
N
I
Q
T
A
E
E
A
L
D
L
I
V
D
A
I
K
A
A
G
H
-
D
G
K
--
V
K
I
G
L
D
C
A
S
S
E
F
F
K
D
G
K
Y
D
-
L
D
F
K
-
N
P
----
N
----
S
-
D
K
S
K
W
L
T
G
----
P
Q
L
A
-
D
L
Y
-
H
S
L
M
K
R
Y
P
I
V
S
I
E
D
P
F
A
E
D
D
W
E
A
W
S
H
F
F
K
T
A
G
--
I
Q
I
V
A
---
D
D
L
T
V
T
N
P
K
R
I
A
T
A
I
E
K
K
A
A
D
A
L
L
L
K
V
N
Q
I
G
T
L
S
E
S
I
K
A
A
Q
D
S
F
A
A
G
W
G
V
M
V
S
H
R
S
G
E
T
E
D
T
F
I
A
D
L
V
V
G
L
R
T
G
Q
I
K
T
G
A
P
A
R
S
E
R
L
A
K
L
N
Q
L
L
R
I
E
E
E
L
G
D
N
A
V
F
A
G
----------