@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : spr1095: (2018-01-04 )
MRKPGNIYTRITNPTTAALEGGVEALATASGMTAVTYTILALAHAGEHVVAASTIYGGTFNLLKEPLPRYGITTTFVDVDNLEEVEAAIKDNTKLVLIETLGNPLINIPDLEKLAEIAHKHQIPLVSDNTFATPYLINVFSHGVDIAIHSATKFIGGHGTTIGGIIVDSGRFDWTASGKFPQFVDESPSCHNLSYTHDVGAAAFIIAVRVQLLRDTGAALSPFNAFLLLQRLETLSLRVERHVQNAETIVDFLVNHPKVEKVNYPKLADSPYYALAEKYLPKGVGSIFTFHVKGDEEEARKVIDNLEIFSDLANAADAKSLVVHPATITHGQLSEKDLEAAGVTPNQIHLSIGLENVEDLIEDLRLALEKI
Atome Classification :
(24 SA)
-----------------------------------------------------.........10....-------.-------...20------......-------...30........40........50........60........70.........80..-.......90.........100.......110.......120-.......130..-...-..140.......150.......160.......170.--......180.......190.......200.......210...-....220.......230.......240.......250.......260.......270.......--280....-...290.......300.......310.......320.......330.......340.......350.......360.......370
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
-----------------------------------------------------MRKPG
N
I
Y
T
R
ITNP
T
-------
T
-------
A
A
L
E-------G
G
V
E
A
L
-------
A
TASG
M
T
A
V
T
Y
T
I
L
A
L
A
HAGE
H
V
V
A
A
S
T
IYG
G
T
F
N
L
L
KEPLPRY-G
I
T
T
T
F
V
DVD-
N
L
-
E
E
V
E
A
A
IK-DN
T
K
L
V
L
I
ETLGNPLINIP
D
L
E
K
L
A
E
I
A
H
K
HQ-IPLVSDNTFA
T
P
-
Y
L
I
-
N
V
FSHGV
D
I
A
I
H
S
A
T
K
FIGGHG
T
T
I
G
G
I
I
VDSG
R
F
D
--WTASGKF
P
Q
F
VDESPSCHN
L
S
YTHDV
G
A
A
A
F
I
I
A
V
R
V
Q
L
L
R
D-TGAAL
S
P
F
N
A
F
L
L
L
Q
R
L
E
T
L
S
L
R
V
E
R
H
VQ
N
A
E
T
I
V
D
F
L
VNHPKVEKVNYPKLADS
P
Y
Y
A
L
A
E
K
Y
--
L
PKGVG
S
-
I
F
T
F
H
VKG
D
E
E
E
A
R
K
V
I
D
N
L
E
I
F
S
D
L
A
NAADA
K
S
L
V
V
H
P
A
TITHGQLS
E
K
D
L
E
AAGVTP
N
Q
I
H
L
S
IG
L
E
N
V
E
D
L
I
E
D
L
R
L
A
L
EKI
1
PsiBlast_PDB
85.24
43%
-5
- C1 -
-
2CTZ
1
?
A:
[45-420]
-----------------------------------------------------
L
K
E
F
G
N
I
Y
S
R
I
M
N
P
T
-------
V
D
V
L
E
K
R
L
A
A
L
E
-------
G
G
K
A
A
L
-------
A
T
A
S
G
H
A
A
Q
F
L
A
L
T
T
L
A
Q
A
G
D
N
I
V
S
T
P
N
L
Y
G
G
T
F
N
Q
F
K
V
T
L
K
R
L
-
G
I
E
V
R
F
T
S
R
E
-
E
R
P
E
E
F
L
A
L
T
D
-
E
K
T
R
A
W
W
V
E
S
I
G
N
P
A
L
N
I
P
D
L
E
A
L
A
Q
A
A
R
E
K
G
-
V
A
L
I
V
D
N
T
F
G
M
G
G
Y
L
L
-
R
P
L
A
W
G
A
A
L
V
T
H
S
L
T
K
W
V
G
G
H
G
A
V
I
A
G
A
I
V
D
G
G
N
F
P
--
W
E
G
-
G
R
Y
P
L
L
T
E
P
Q
P
G
Y
H
G
L
R
L
T
E
A
F
G
E
L
A
F
I
V
K
A
R
V
D
G
L
R
D
-
Q
G
Q
A
L
G
P
F
E
A
W
V
V
L
L
G
M
E
T
L
S
L
R
A
E
R
H
V
E
N
T
L
H
L
A
H
W
L
L
E
Q
P
Q
V
A
W
V
N
Y
P
G
L
P
H
H
P
H
H
D
R
A
Q
K
Y
--
F
K
G
K
P
G
A
-
V
L
T
F
G
L
K
G
G
Y
E
A
A
K
R
F
I
S
R
L
K
L
I
S
H
L
A
N
V
G
D
T
R
T
L
A
I
H
P
A
S
T
T
H
S
Q
L
S
P
E
E
Q
A
Q
A
G
V
S
P
E
M
V
R
L
S
V
G
L
E
H
V
E
D
L
K
A
E
L
K
E
A
L
---
21
PsiBlast_CBE
84.98
43%
-7
- C1 -
-
2CTZ
1
?
B:
[45-420]
-----------------------------------------------------
L
K
E
F
G
N
I
Y
S
R
I
M
N
P
T
-------
V
DVLEKRL
A
A
L
E
-------
G
G
K
A
A
L
-------
A
T
A
S
G
H
A
A
Q
F
L
A
L
T
T
L
A
Q
A
G
D
N
I
V
S
T
P
N
L
Y
G
G
T
F
N
Q
F
K
V
T
L
K
R
L
-
G
I
E
V
R
F
T
S
R
E
-
E
R
P
E
E
F
L
A
L
T
D
-
E
K
T
R
A
W
W
V
E
S
I
G
N
P
A
L
N
I
P
D
L
E
A
L
A
Q
A
A
R
E
K
G
-
V
A
L
I
V
D
N
T
F
G
M
G
G
Y
L
L
-
R
P
L
A
W
G
A
A
L
V
T
H
S
L
T
K
W
V
G
G
H
G
A
V
I
A
G
A
I
V
D
G
G
N
F
P
--
W
E
G
-
G
R
Y
P
L
L
T
E
P
Q
P
G
Y
H
G
L
R
L
T
E
A
F
G
E
L
A
F
I
V
K
A
R
V
D
G
L
R
D
-
Q
G
Q
A
L
G
P
F
E
A
W
V
V
L
L
G
M
E
T
L
S
L
R
A
E
R
H
V
E
N
T
L
H
L
A
H
W
L
L
E
Q
P
Q
V
A
W
V
N
Y
P
G
L
P
H
H
P
H
H
D
R
A
Q
K
Y
--
F
K
G
K
P
G
A
-
V
L
T
F
G
L
K
G
G
Y
E
A
A
K
R
F
I
S
R
L
K
L
I
S
H
L
A
N
V
G
D
T
R
T
L
A
I
H
P
A
S
T
T
H
S
Q
L
S
P
E
E
Q
A
Q
A
G
V
S
P
E
M
V
R
L
S
V
G
L
E
H
V
E
D
L
K
A
E
L
K
E
A
L
---
137
HHSearch
83.58
44%
-3
- C1 -
-
2CTZ
1
?
B:
[47-421]
-------------------------------------------------------
E
F
G
N
I
Y
S
R
I
M
N
P
T
-------
V
-------
D
V
L
E
KRLAALE
G
G
K
A
A
L
-------
A
T
A
S
G
H
A
A
Q
F
L
A
L
T
T
L
A
Q
A
G
D
N
I
V
S
T
P
N
L
Y
G
G
T
F
N
Q
F
K
V
T
L
K
R
L
-
G
I
E
V
R
F
T
S
R
E
E
R
P
-
E
E
F
L
A
L
T
D
-
E
K
T
R
A
W
W
V
E
S
I
G
N
P
A
L
N
I
P
D
L
E
A
L
A
Q
A
A
R
E
K
G
-
V
A
L
I
V
D
N
T
F
G
M
G
-
G
Y
L
L
R
P
L
A
W
G
A
A
L
V
T
H
S
L
T
K
W
V
G
G
H
G
A
V
I
A
G
A
I
V
D
G
G
N
F
P
--
W
E
G
G
-
R
Y
P
L
L
T
E
P
Q
P
G
Y
H
G
L
R
L
T
E
A
F
G
E
L
A
F
I
V
K
A
R
V
D
G
L
R
D
-
Q
G
Q
A
L
G
P
F
E
A
W
V
V
L
L
G
M
E
T
L
S
L
R
A
E
R
H
V
E
N
T
L
H
L
A
H
W
L
L
E
Q
P
Q
V
A
W
V
N
Y
P
G
L
P
H
H
P
H
H
D
R
A
Q
K
Y
--
F
K
G
K
P
G
A
-
V
L
T
F
G
L
K
G
G
Y
E
A
A
K
R
F
I
S
R
L
K
L
I
S
H
L
A
N
V
G
D
T
R
T
L
A
I
H
P
A
S
T
T
H
S
Q
L
S
P
E
E
Q
A
Q
A
G
V
S
P
E
M
V
R
L
S
V
G
L
E
H
V
E
D
L
K
A
E
L
K
E
A
L
A
--
29
PsiBlast_CBE
82.28
35%
-25
- C1 -
-
5X2X
3
MEGL_PSEPU
C:
[54-395]
-------------------------------------------------------
Q
A
G
H
F
Y
S
R
I
S
N
P
T
LNLLEAR
M
-------
A
S
L
E
-------
G
G
E
A
G
L
-------
A
L
A
S
G
M
G
A
I
T
S
T
L
W
T
L
L
R
P
G
D
E
V
L
L
G
N
T
L
Y
G
C
T
F
A
F
L
H
H
G
I
G
E
F
-
G
V
K
L
R
H
V
D
M
A
-
D
L
-
Q
A
L
E
A
A
M
T
-
P
A
T
R
V
I
Y
F
E
S
P
A
N
P
N
M
H
M
A
D
I
A
G
V
A
K
I
A
R
K
H
G
-
A
T
V
V
V
D
N
T
Y
C
T
P
-
Y
L
Q
-
R
P
L
E
L
G
A
D
L
V
V
H
S
A
T
K
Y
L
S
G
H
G
D
I
T
A
G
I
V
----------------------------------
V
G
S
Q
A
L
V
D
R
I
R
L
Q
G
L
K
D
M
T
G
A
V
L
S
P
H
D
A
A
L
L
M
R
G
I
K
T
L
N
L
R
M
D
R
H
C
A
N
A
Q
V
L
A
E
F
L
A
R
Q
P
Q
V
E
L
I
H
Y
P
G
L
A
S
F
P
Q
Y
T
L
A
R
Q
Q
--
M
S
Q
-
P
G
G
-
M
I
A
F
E
L
K
G
G
I
G
A
G
R
R
F
M
N
A
L
Q
L
F
S
R
A
V
S
L
G
D
A
E
S
L
A
Q
H
P
A
S
M
T
H
S
S
Y
T
P
E
E
R
A
H
Y
G
I
S
E
G
L
V
R
L
S
V
G
L
E
D
I
D
D
L
L
A
D
V
Q
Q
A
L
K
--
39
PsiBlast_CBE
82.12
35%
-26
- C1 -
-
5X2Z
1
MEGL_PSEPU
C:
[54-395]
-------------------------------------------------------
Q
A
G
H
F
Y
S
R
I
S
N
P
T
LNLLEAR
M
-------
A
S
L
E
-------
G
G
E
A
G
L
-------
A
L
A
S
G
M
G
A
I
T
S
T
L
W
T
L
L
R
P
G
D
E
V
L
L
G
N
T
L
Y
G
H
T
F
A
F
L
H
H
G
I
G
E
F
-
G
V
K
L
R
H
V
D
M
A
-
D
L
-
Q
A
L
E
A
A
M
T
-
P
A
T
R
V
I
Y
F
E
S
P
A
N
P
N
M
H
M
A
D
I
A
G
V
A
K
I
A
R
K
H
G
-
A
T
V
V
V
D
N
T
Y
C
T
P
-
Y
L
Q
-
R
P
L
E
L
G
A
D
L
V
V
H
S
A
T
K
Y
L
S
G
H
G
D
I
T
A
G
I
V
----------------------------------
V
G
S
Q
A
L
V
D
R
I
R
L
Q
G
L
K
D
M
T
G
A
V
L
S
P
H
D
A
A
L
L
M
R
G
I
K
T
L
N
L
R
M
D
R
H
C
A
N
A
Q
V
L
A
E
F
L
A
R
Q
P
Q
V
E
L
I
H
Y
P
G
L
A
S
F
P
Q
Y
T
L
A
R
Q
Q
--
M
S
Q
-
P
G
G
-
M
I
A
F
E
L
K
G
G
I
G
A
G
R
R
F
M
N
A
L
Q
L
F
S
R
A
V
S
L
G
D
A
E
S
L
A
Q
H
P
A
S
M
T
H
S
S
Y
T
P
E
E
R
A
H
Y
G
I
S
E
G
L
V
R
L
S
V
G
L
E
D
I
D
D
L
L
A
D
V
Q
Q
A
L
K
--
133
HHSearch
82.08
43%
-22
- C1 -
-
4P7Y
2
?
A:
[53-395]
--------------------------------------------------------
S
G
Y
I
F
T
R
L
G
N
P
T
-------
T
-------
D
A
L
E
K
K
L
A
V
L
E
R
G
E
A
G
L
-------
A
T
A
S
G
I
S
A
I
T
T
T
L
L
T
L
C
Q
Q
G
D
H
I
V
S
A
S
A
I
Y
G
C
T
H
A
F
L
S
H
S
M
P
K
F
-
G
I
N
V
S
F
V
D
A
A
-
K
P
-
E
E
I
R
A
A
M
R
-
P
E
T
K
V
V
Y
I
E
T
P
A
N
P
T
L
S
L
V
D
I
E
T
V
A
G
I
A
H
Q
Q
G
-
A
L
L
V
V
D
N
T
F
M
S
P
-
Y
C
Q
-
Q
P
L
Q
L
G
A
D
I
V
V
H
S
V
T
K
Y
I
N
G
H
G
D
V
I
G
G
I
I
V
G
K
-
Q
E
F
--
I
D
Q
A
------------------------------
R
F
V
G
L
K
D
I
-
T
G
G
C
M
S
P
F
N
A
W
L
T
L
R
G
V
K
T
L
G
I
R
M
E
R
H
C
E
N
A
L
K
I
A
R
F
L
E
G
H
P
S
I
T
R
V
Y
Y
P
G
L
S
S
H
P
Q
Y
E
L
G
Q
R
Q
--
M
S
-
L
P
G
G
-
I
I
S
F
E
I
A
G
G
L
E
A
G
R
R
M
I
N
S
V
E
L
C
L
L
A
V
S
L
G
D
T
E
T
L
I
Q
H
P
A
S
M
T
H
S
P
V
A
P
E
E
R
L
K
A
G
I
T
D
G
L
I
R
L
S
V
G
L
E
D
P
E
D
I
I
N
D
L
E
H
A
I
R
K
A
99
PsiBlast_CBE
81.89
36%
-23
- C1 -
-
4IY7
7
?
A:
[58-393]
------------------------------------------------------------
Y
S
R
T
H
N
P
T
R
F
A
Y
E
R
C
V
-------
A
A
L
E
-------
G
G
T
R
A
F
-------
A
F
A
S
G
M
-
A
A
T
S
T
V
M
E
L
L
D
A
G
S
H
V
V
A
M
D
D
L
Y
G
G
T
F
R
L
F
E
R
V
R
R
R
T
A
G
L
D
F
S
F
V
D
L
T
-
D
P
-
A
A
F
K
A
A
I
R
-
A
D
T
K
M
V
W
I
E
T
P
T
N
P
M
L
K
L
V
D
I
A
A
I
A
V
I
A
R
K
H
G
-
L
L
T
V
V
D
N
T
F
A
S
P
-
M
L
Q
-
R
P
L
S
L
G
A
D
L
V
V
H
S
A
T
K
Y
L
N
G
H
S
D
M
V
G
G
I
A
V
---------------------------------
V
G
D
N
A
E
L
A
E
Q
M
A
F
L
Q
N
S
-
I
G
G
V
Q
G
P
F
D
S
F
L
A
L
R
G
L
K
T
L
P
L
R
M
R
A
H
C
E
N
A
L
A
L
A
Q
W
L
E
T
H
P
A
I
E
K
V
I
Y
P
G
L
A
S
H
P
Q
H
V
L
A
K
R
Q
--
M
-
S
G
F
G
G
-
I
V
S
I
V
L
K
G
G
F
D
A
A
K
R
F
C
E
K
T
E
L
F
T
L
A
E
S
L
G
G
V
E
S
L
V
N
H
P
A
V
M
T
H
A
S
I
P
V
A
R
R
E
Q
L
G
I
S
D
A
L
V
R
L
S
V
G
I
E
D
L
G
D
L
R
G
D
L
E
R
A
L
---
32
PsiBlast_CBE
81.85
35%
-25
- C1 -
-
5X2W
2
MEGL_PSEPU
C:
[54-395]
-------------------------------------------------------
Q
A
G
H
F
Y
S
R
I
S
N
P
T
LNLLEAR
M
-------
A
S
L
E
-------
G
G
E
A
G
L
-------
A
L
A
S
G
M
G
A
I
T
S
T
L
W
T
L
L
R
P
G
D
E
V
L
L
G
N
T
L
Y
G
C
T
F
A
F
L
H
H
G
I
G
E
F
-
G
V
K
L
R
H
V
D
M
A
-
D
L
-
Q
A
L
E
A
A
M
T
-
P
A
T
R
V
I
Y
F
E
S
P
A
N
P
N
M
H
M
A
D
I
A
G
V
A
K
I
A
R
K
H
G
-
A
T
V
V
V
D
N
T
Y
C
T
P
-
Y
L
Q
-
R
P
L
E
L
G
A
D
L
V
V
H
S
A
T
K
Y
L
S
G
H
G
D
I
T
A
G
I
V
----------------------------------
V
G
S
Q
A
L
V
D
R
I
R
L
Q
G
L
K
D
M
T
G
A
V
L
S
P
H
D
A
A
L
L
M
R
G
I
K
T
L
N
L
R
M
D
R
H
C
A
N
A
Q
V
L
A
E
F
L
A
R
Q
P
Q
V
E
L
I
H
Y
P
G
L
A
S
F
P
Q
Y
T
L
A
R
Q
Q
--
M
S
Q
-
P
G
G
-
M
I
A
F
E
L
K
G
G
I
G
A
G
R
R
F
M
N
A
L
Q
L
F
S
R
A
V
S
L
G
D
A
E
S
L
A
Q
H
P
A
S
M
T
H
S
S
Y
T
P
E
E
R
A
H
Y
G
I
S
E
G
L
V
R
L
S
V
G
L
E
D
I
D
D
L
L
A
D
V
Q
Q
A
L
K
--
98
PsiBlast_CBE
81.50
36%
-21
- C1 -
-
4IY7
5
?
B:
[58-393]
------------------------------------------------------------
Y
S
R
T
H
N
P
T
RFAYERC
V
-------
A
A
L
E
-------
G
G
T
R
A
F
-------
A
F
A
S
G
M
-
A
A
T
S
T
V
M
E
L
L
D
A
G
S
H
V
V
A
M
D
D
L
Y
G
G
T
F
R
L
F
E
R
V
R
R
R
T
A
G
L
D
F
S
F
V
D
L
T
-
D
P
-
A
A
F
K
A
A
I
R
-
A
D
T
K
M
V
W
I
E
T
P
T
N
P
M
L
K
L
V
D
I
A
A
I
A
V
I
A
R
K
H
G
-
L
L
T
V
V
D
N
T
F
A
S
P
-
M
L
Q
-
R
P
L
S
L
G
A
D
L
V
V
H
S
A
T
K
Y
L
N
G
H
S
D
M
V
G
G
I
A
V
---------------------------------
V
G
D
N
A
E
L
A
E
Q
M
A
F
L
Q
N
S
-
I
G
G
V
Q
G
P
F
D
S
F
L
A
L
R
G
L
K
T
L
P
L
R
M
R
A
H
C
E
N
A
L
A
L
A
Q
W
L
E
T
H
P
A
I
E
K
V
I
Y
P
G
L
A
S
H
P
Q
H
V
L
A
K
R
Q
--
M
-
S
G
F
G
G
-
I
V
S
I
V
L
K
G
G
F
D
A
A
K
R
F
C
E
K
T
E
L
F
T
L
A
E
S
L
G
G
V
E
S
L
V
N
H
P
A
V
M
T
H
A
S
I
P
V
A
R
R
E
Q
L
G
I
S
D
A
L
V
R
L
S
V
G
I
E
D
L
G
D
L
R
G
D
L
E
R
A
L
---
18
PsiBlast_PDB
81.17
34%
-25
- C1 -
-
1UKJ
-
MEGL_PSEPU
A:
[54-395]
-------------------------------------------------------
Q
A
G
H
F
Y
S
R
I
S
N
P
T
L
N
L
L
E
A
R
M
-------
A
S
L
E
-------
G
G
E
A
G
L
-------
A
L
A
S
G
M
G
A
I
T
S
T
L
W
T
L
L
R
P
G
D
E
V
L
L
G
N
T
L
Y
G
C
T
F
A
F
L
H
H
G
I
G
E
F
-
G
V
K
L
R
H
V
D
M
A
-
D
L
-
Q
A
L
E
A
A
M
T
-
P
A
T
R
V
I
Y
F
E
S
P
A
N
P
N
M
H
M
A
D
I
A
G
V
A
K
I
A
R
K
H
G
-
A
T
V
V
V
D
N
T
Y
C
T
P
-
Y
L
Q
-
R
P
L
E
L
G
A
D
L
V
V
H
S
A
T
K
Y
L
S
G
H
G
D
I
T
A
G
I
V
----------------------------------
V
G
S
Q
A
L
V
D
R
I
R
L
Q
G
L
K
D
M
T
G
A
V
L
S
P
H
D
A
A
L
L
M
R
G
I
K
T
L
N
L
R
M
D
R
H
C
A
N
A
Q
V
L
A
E
F
L
A
R
Q
P
Q
V
E
L
I
H
Y
P
G
L
A
S
F
P
Q
Y
T
L
A
R
Q
Q
--
M
S
Q
-
P
G
G
-
M
I
A
F
E
L
K
G
G
I
G
A
G
R
R
F
M
N
A
L
Q
L
F
S
R
A
V
S
L
G
D
A
E
S
L
A
Q
H
P
A
S
M
T
H
S
S
Y
T
P
E
E
R
A
H
Y
G
I
S
E
G
L
V
R
L
S
V
G
L
E
D
I
D
D
L
L
A
D
V
Q
Q
A
L
K
--
16
PsiBlast_PDB
81.01
35%
-23
- C1 -
-
5X2Z
1
MEGL_PSEPU
A:
[54-395]
-------------------------------------------------------
Q
A
G
H
F
Y
S
R
I
S
N
P
T
L
N
L
L
E
A
R
M
-------
A
S
L
E
-------
G
G
E
A
G
L
-------
A
L
A
S
G
M
G
A
I
T
S
T
L
W
T
L
L
R
P
G
D
E
V
L
L
G
N
T
L
Y
G
H
T
F
A
F
L
H
H
G
I
G
E
F
-
G
V
K
L
R
H
V
D
M
A
-
D
L
-
Q
A
L
E
A
A
M
T
-
P
A
T
R
V
I
Y
F
E
S
P
A
N
P
N
M
H
M
A
D
I
A
G
V
A
K
I
A
R
K
H
G
-
A
T
V
V
V
D
N
T
Y
C
T
P
-
Y
L
Q
-
R
P
L
E
L
G
A
D
L
V
V
H
S
A
T
K
Y
L
S
G
H
G
D
I
T
A
G
I
V
----------------------------------
V
G
S
Q
A
L
V
D
R
I
R
L
Q
G
L
K
D
M
T
G
A
V
L
S
P
H
D
A
A
L
L
M
R
G
I
K
T
L
N
L
R
M
D
R
H
C
A
N
A
Q
V
L
A
E
F
L
A
R
Q
P
Q
V
E
L
I
H
Y
P
G
L
A
S
F
P
Q
Y
T
L
A
R
Q
Q
--
M
S
Q
-
P
G
G
-
M
I
A
F
E
L
K
G
G
I
G
A
G
R
R
F
M
N
A
L
Q
L
F
S
R
A
V
S
L
G
D
A
E
S
L
A
Q
H
P
A
S
M
T
H
S
S
Y
T
P
E
E
R
A
H
Y
G
I
S
E
G
L
V
R
L
S
V
G
L
E
D
I
D
D
L
L
A
D
V
Q
Q
A
L
K
--
121
Fugue
80.86
34%
-26
- C1 -
-
1QGN
2
?
A:
[49-445]
KYASFLNS
D
G
S
V
A
I
HAGERLGRGIVTDAI
T
T
P
V
V
NTS
A
Y
F
F
NK
T
S
E
L
I
D
F
K
E
K
R
R
A
-
S
F
E
Y
G
R
Y
G
N
P
T
-------
T
V
V
L
E
E
K
I
S
A
L
E
-------
G
A
E
S
T
L
-------
L
M
A
S
G
M
C
A
S
T
V
M
L
L
A
L
V
P
A
G
G
H
I
V
T
T
T
D
C
Y
R
K
T
R
I
F
I
E
T
I
L
P
K
M
-
G
I
T
A
T
V
I
D
P
A
-
D
V
-
G
A
L
E
L
A
L
N
Q
K
K
V
N
L
F
F
T
E
S
P
T
N
P
F
L
R
C
V
D
I
E
L
V
S
K
L
C
H
E
K
-G
A
L
V
C
I
D
G
T
F
A
T
P
-
L
N
Q
-
K
A
L
A
L
G
A
D
L
V
L
H
S
A
T
K
F
L
G
G
H
N
D
V
L
A
G
C
I
S
G
-
P
----------------------------------
L
K
L
V
S
E
I
R
N
L
H
H
I
-
L
G
G
A
L
N
P
N
A
A
Y
L
I
I
R
G
M
K
T
L
H
L
R
V
Q
Q
Q
N
S
T
A
L
R
M
A
E
I
L
E
A
H
P
K
V
R
H
V
Y
Y
P
G
L
Q
S
H
P
E
H
H
I
A
K
K
Q
--
M
-
T
G
F
G
G
-
A
V
S
F
E
V
D
G
D
L
L
T
T
A
K
F
V
D
A
L
K
I
P
Y
I
A
P
S
F
G
G
C
E
S
I
V
D
Q
P
A
I
M
S
Y
W
D
L
S
Q
S
D
R
A
K
Y
G
I
M
D
N
L
V
R
F
S
F
G
V
E
D
F
D
D
L
K
A
D
I
L
Q
A
L
D
S
I
96
PsiBlast_CBE
80.68
36%
-19
- C1 -
-
4IY7
5
?
D:
[58-393]
------------------------------------------------------------
Y
S
R
T
H
N
P
T
RFAYERC
V
-------
A
A
L
E
-------
G
G
T
R
A
F
-------
A
F
A
S
G
M
-
A
A
T
S
T
V
M
E
L
L
D
A
G
S
H
V
V
A
M
D
D
L
Y
G
G
T
F
R
L
F
E
R
V
R
R
R
T
A
G
L
D
F
S
F
V
D
L
T
-
D
P
-
A
A
F
K
A
A
I
R
-
A
D
T
K
M
V
W
I
E
T
P
T
N
P
M
L
K
L
V
D
I
A
A
I
A
V
I
A
R
K
H
G
-
L
L
T
V
V
D
N
T
F
A
S
P
-
M
L
Q
-
R
P
L
S
L
G
A
D
L
V
V
H
S
A
T
K
Y
L
N
G
H
S
D
M
V
G
G
I
A
V
---------------------------------
V
G
D
N
A
E
L
A
E
Q
M
A
F
L
Q
N
S
-
I
G
G
V
Q
G
P
F
D
S
F
L
A
L
R
G
L
K
T
L
P
L
R
M
R
A
H
C
E
N
A
L
A
L
A
Q
W
L
E
T
H
P
A
I
E
K
V
I
Y
P
G
L
A
S
H
P
Q
H
V
L
A
K
R
Q
--
M
-
S
G
F
G
G
-
I
V
S
I
V
L
K
G
G
F
D
A
A
K
R
F
C
E
K
T
E
L
F
T
L
A
E
S
L
G
G
V
E
S
L
V
N
H
P
A
V
M
T
H
A
S
I
P
V
A
R
R
E
Q
L
G
I
S
D
A
L
V
R
L
S
V
G
I
E
D
L
G
D
L
R
G
D
L
E
R
A
L
---
35
PsiBlast_CBE
80.66
35%
-22
- C1 -
-
1PG8
4
MEGL_PSEPU
C:
[54-395]
-------------------------------------------------------
Q
A
G
H
F
Y
S
R
I
S
N
P
T
LNLLEAR
M
-------
A
S
L
E
-------
G
G
E
A
G
L
-------
A
L
A
S
G
M
G
A
I
T
S
T
L
W
T
L
L
R
P
G
D
E
V
L
L
G
N
T
L
Y
G
C
T
F
A
F
L
H
H
G
I
G
E
F
-
G
V
K
L
R
H
V
D
M
A
-
D
L
-
Q
A
L
E
A
A
M
T
-
P
A
T
R
V
I
Y
F
E
S
P
A
N
P
N
M
H
M
A
D
I
A
G
V
A
K
I
A
R
K
H
G
-
A
T
V
V
V
D
N
T
Y
C
T
P
-
Y
L
Q
-
R
P
L
E
L
G
A
D
L
V
V
H
S
A
T
K
Y
L
S
G
H
G
D
I
T
A
G
I
V
----------------------------------
V
G
S
Q
A
L
V
D
R
I
R
L
Q
G
L
K
D
M
T
G
A
V
L
S
P
H
D
A
A
L
L
M
R
G
I
K
T
L
N
L
R
M
D
R
H
C
A
N
A
Q
V
L
A
E
F
L
A
R
Q
P
Q
V
E
L
I
H
Y
P
G
L
A
S
F
P
Q
Y
T
L
A
R
Q
Q
--
M
S
Q
-
P
G
G
-
M
I
A
F
E
L
K
G
G
I
G
A
G
R
R
F
M
N
A
L
Q
L
F
S
R
A
V
S
L
G
D
A
E
S
L
A
Q
H
P
A
S
M
T
H
S
S
Y
T
P
E
E
R
A
H
Y
G
I
S
E
G
L
V
R
L
S
V
G
L
E
D
I
D
D
L
L
A
D
V
Q
Q
A
L
K
--
28
PsiBlast_CBE
80.47
35%
-23
- C1 -
-
5X2X
3
MEGL_PSEPU
D:
[54-395]
-------------------------------------------------------
Q
A
G
H
F
Y
S
R
I
S
N
P
T
LNLLEAR
M
-------
A
S
L
E
-------
G
G
E
A
G
L
-------
A
L
A
S
G
M
G
A
I
T
S
T
L
W
T
L
L
R
P
G
D
E
V
L
L
G
N
T
L
Y
G
C
T
F
A
F
L
H
H
G
I
G
E
F
-
G
V
K
L
R
H
V
D
M
A
-
D
L
-
Q
A
L
E
A
A
M
T
-
P
A
T
R
V
I
Y
F
E
S
P
A
N
P
N
M
H
M
A
D
I
A
G
V
A
K
I
A
R
K
H
G
-
A
T
V
V
V
D
N
T
Y
C
T
P
-
Y
L
Q
-
R
P
L
E
L
G
A
D
L
V
V
H
S
A
T
K
Y
L
S
G
H
G
D
I
T
A
G
I
V
----------------------------------
V
G
S
Q
A
L
V
D
R
I
R
L
Q
G
L
K
D
M
T
G
A
V
L
S
P
H
D
A
A
L
L
M
R
G
I
K
T
L
N
L
R
M
D
R
H
C
A
N
A
Q
V
L
A
E
F
L
A
R
Q
P
Q
V
E
L
I
H
Y
P
G
L
A
S
F
P
Q
Y
T
L
A
R
Q
Q
--
M
S
Q
-
P
G
G
-
M
I
A
F
E
L
K
G
G
I
G
A
G
R
R
F
M
N
A
L
Q
L
F
S
R
A
V
S
L
G
D
A
E
S
L
A
Q
H
P
A
S
M
T
H
S
S
Y
T
P
E
E
R
A
H
Y
G
I
S
E
G
L
V
R
L
S
V
G
L
E
D
I
D
D
L
L
A
D
V
Q
Q
A
L
K
--
95
PsiBlast_CBE
80.40
36%
-21
- C1 -
-
4IYO
7
?
A:
[58-393]
------------------------------------------------------------
Y
S
R
T
H
N
P
T
R
F
A
Y
E
R
C
V
-------
A
A
L
E
-------
G
G
T
R
A
F
-------
A
F
A
S
G
M
-
A
A
T
S
T
V
M
E
L
L
D
A
G
S
H
V
V
A
M
D
D
L
Y
G
G
T
F
R
L
F
E
R
V
R
R
R
T
A
G
L
D
F
S
F
V
D
L
T
-
D
P
-
A
A
F
K
A
A
I
R
-
A
D
T
K
M
V
W
I
E
T
P
T
N
P
M
L
K
L
V
D
I
A
A
I
A
V
I
A
R
K
H
G
-
L
L
T
V
V
D
N
T
F
A
S
P
-
M
L
Q
-
R
P
L
S
L
G
A
D
L
V
V
H
S
A
T
K
Y
L
N
G
H
S
D
M
V
G
G
I
A
V
---------------------------------
V
G
D
N
A
E
L
A
E
Q
M
A
F
L
Q
N
S
-
I
G
G
V
Q
G
P
F
D
S
F
L
A
L
R
G
L
K
T
L
P
L
R
M
R
A
H
C
E
N
A
L
A
L
A
Q
W
L
E
T
H
P
A
I
E
K
V
I
Y
P
G
L
A
S
H
P
Q
H
V
L
A
K
R
Q
--
M
-
S
G
F
G
G
-
I
V
S
I
V
L
K
G
G
F
D
A
A
K
R
F
C
E
K
T
E
L
F
T
L
A
E
S
L
G
G
V
E
S
L
V
N
H
P
A
V
M
T
H
A
S
I
P
V
A
R
R
E
Q
L
G
I
S
D
A
L
V
R
L
S
V
G
I
E
D
L
G
D
L
R
G
D
L
E
R
A
L
---
19
PsiBlast_PDB
80.37
34%
-22
- C1 -
-
2O7C
-
MEGL_PSEPU
A:
[54-395]
-------------------------------------------------------
Q
A
G
H
F
Y
S
R
I
S
N
P
T
L
N
L
L
E
A
R
M
-------
A
S
L
E
-------
G
G
E
A
G
L
-------
A
L
A
S
G
M
G
A
I
T
S
T
L
W
T
L
L
R
P
G
D
E
V
L
L
G
N
T
L
Y
G
C
T
F
A
F
L
H
H
G
I
G
E
F
-
G
V
K
L
R
H
V
D
M
A
-
D
L
-
Q
A
L
E
A
A
M
T
-
P
A
T
R
V
I
Y
F
E
S
P
A
N
P
N
M
H
M
A
D
I
A
G
V
A
K
I
A
R
K
H
G
-
A
T
V
V
V
D
N
T
Y
C
T
P
-
Y
L
Q
-
R
P
L
E
L
G
A
D
L
V
V
H
S
A
T
K
Y
L
S
G
H
G
D
I
T
A
G
I
V
----------------------------------
V
G
S
Q
A
L
V
D
R
I
R
L
Q
G
L
K
D
M
T
G
A
V
L
S
P
H
D
A
A
L
L
M
R
G
I
K
T
L
N
L
R
M
D
R
H
C
A
N
A
Q
V
L
A
E
F
L
A
R
Q
P
Q
V
E
L
I
H
Y
P
G
L
A
S
F
P
Q
Y
T
L
A
R
Q
Q
--
M
S
Q
-
P
G
G
-
M
I
A
F
E
L
K
G
G
I
G
A
G
R
R
F
M
N
A
L
Q
L
F
S
R
A
V
S
L
G
D
A
E
S
L
A
Q
H
P
A
S
M
T
H
S
S
Y
T
P
E
E
R
A
H
Y
G
I
S
E
G
L
V
R
L
S
V
G
L
E
D
I
D
D
L
L
A
D
V
Q
Q
A
L
K
--
2
PsiBlast_PDB
80.32
42%
8
- C1 -
-
4OC9
2
?
A:
[47-423]
-----------------------------------------------------
L
Q
E
L
G
N
I
Y
S
R
L
S
N
P
T
-------
S
D
V
L
G
Q
R
L
A
N
V
E
-------
G
G
A
F
G
I
-------
P
V
A
S
G
M
A
A
C
F
Y
A
L
I
N
L
A
S
S
G
D
N
V
A
Y
S
N
K
I
Y
G
G
T
Q
T
L
I
S
H
T
L
K
N
F
-
G
I
E
A
R
E
F
D
I
D
-
D
L
-
D
S
L
E
K
V
I
D
-
Q
N
T
K
A
I
F
F
E
S
L
S
N
P
Q
I
A
I
A
D
I
E
K
I
N
Q
I
A
K
K
H
K
-
I
V
S
I
C
D
N
T
V
A
T
P
-
F
L
L
-
Q
P
F
K
H
G
V
D
V
I
V
H
S
L
S
K
Y
V
S
G
Q
G
T
A
L
G
G
A
L
I
E
R
K
D
L
N
D
L
L
K
N
N
D
R
Y
K
A
F
N
T
P
D
P
S
Y
H
G
L
N
L
-
N
T
L
D
L
P
I
F
S
I
R
V
I
I
T
W
L
R
D
-
L
G
A
S
L
A
P
Q
N
A
W
L
L
L
Q
G
L
E
T
L
A
V
R
I
E
K
H
S
Q
N
A
E
K
V
A
N
F
L
N
S
H
P
D
I
K
G
V
N
Y
P
T
L
A
S
N
A
Y
H
N
L
F
K
K
Y
--
F
D
K
N
F
A
S
G
L
L
S
F
E
A
K
-
D
Y
E
H
A
R
R
I
C
D
K
T
Q
L
F
L
L
A
A
N
L
G
D
S
K
S
L
I
I
H
P
A
S
T
T
H
S
Q
L
S
E
E
E
L
Q
K
A
G
I
T
K
A
T
I
R
L
S
I
G
L
E
N
S
D
D
L
I
A
D
L
K
Q
A
I
E
--
23
PsiBlast_CBE
80.26
42%
10
- C1 -
-
4OC9
1
?
G:
[47-423]
-----------------------------------------------------
L
Q
E
L
G
N
I
Y
S
R
L
S
N
P
T
-------
S
DVLGQRL
A
N
V
E
-------
G
G
A
F
G
I
-------
P
V
A
S
G
M
A
A
C
F
Y
A
L
I
N
L
A
S
S
G
D
N
V
A
Y
S
N
K
I
Y
G
G
T
Q
T
L
I
S
H
T
L
K
N
F
-
G
I
E
A
R
E
F
D
I
D
-
D
L
-
D
S
L
E
K
V
I
D
-
Q
N
T
K
A
I
F
F
E
S
L
S
N
P
Q
I
A
I
A
D
I
E
K
I
N
Q
I
A
K
K
H
K
-
I
V
S
I
C
D
N
T
V
A
T
P
-
F
L
L
-
Q
P
F
K
H
G
V
D
V
I
V
H
S
L
S
K
Y
V
S
G
Q
G
T
A
L
G
G
A
L
I
E
R
K
D
L
N
DL
L
K
N
N
D
R
Y
K
A
F
N
T
P
D
P
S
Y
H
G
L
N
L
-
N
T
L
D
L
P
I
F
S
I
R
V
I
I
T
W
L
R
D
-
L
G
A
S
L
A
P
Q
N
A
W
L
L
L
Q
G
L
E
T
L
A
V
R
I
E
K
H
S
Q
N
A
E
K
V
A
N
F
L
N
S
H
P
D
I
K
G
V
N
Y
P
T
L
A
S
N
A
Y
H
N
L
F
K
K
Y
--
F
D
K
N
F
A
S
G
L
L
S
F
E
A
K
-
D
Y
E
H
A
R
R
I
C
D
K
T
Q
L
F
L
L
A
A
N
L
G
D
S
K
S
L
I
I
H
P
A
S
T
T
H
S
Q
L
S
E
E
E
L
Q
K
A
G
I
T
K
A
T
I
R
L
S
I
G
L
E
N
S
D
D
L
I
A
D
L
K
Q
A
I
E
--
24
PsiBlast_CBE
80.25
42%
9
- C1 -
-
4OC9
2
?
D:
[47-423]
-----------------------------------------------------
L
Q
E
L
G
N
I
Y
S
R
L
S
N
P
T
-------
S
DVLGQRL
A
N
V
E
-------
G
G
A
F
G
I
-------
P
V
A
S
G
M
A
A
C
F
Y
A
L
I
N
L
A
S
S
G
D
N
V
A
Y
S
N
K
I
Y
G
G
T
Q
T
L
I
S
H
T
L
K
N
F
-
G
I
E
A
R
E
F
D
I
D
-
D
L
-
D
S
L
E
K
V
I
D
-
Q
N
T
K
A
I
F
F
E
S
L
S
N
P
Q
I
A
I
A
D
I
E
K
I
N
Q
I
A
K
K
H
K
-
I
V
S
I
C
D
N
T
V
A
T
P
-
F
L
L
-
Q
P
F
K
H
G
V
D
V
I
V
H
S
L
S
K
Y
V
S
G
Q
G
T
A
L
G
G
A
L
I
E
R
K
D
L
N
DL
L
K
N
N
D
R
Y
K
A
F
N
T
P
D
P
S
Y
H
G
L
N
L
-
N
T
L
D
L
P
I
F
S
I
R
V
I
I
T
W
L
R
D
-
L
G
A
S
L
A
P
Q
N
A
W
L
L
L
Q
G
L
E
T
L
A
V
R
I
E
K
H
S
Q
N
A
E
K
V
A
N
F
L
N
S
H
P
D
I
K
G
V
N
Y
P
T
L
A
S
N
A
Y
H
N
L
F
K
K
Y
--
F
D
K
N
F
A
S
G
L
L
S
F
E
A
K
-
D
Y
E
H
A
R
R
I
C
D
K
T
Q
L
F
L
L
A
A
N
L
G
D
S
K
S
L
I
I
H
P
A
S
T
T
H
S
Q
L
S
E
E
E
L
Q
K
A
G
I
T
K
A
T
I
R
L
S
I
G
L
E
N
S
D
D
L
I
A
D
L
K
Q
A
I
E
--
5
PsiBlast_PDB
79.36
39%
-14
- C1 -
-
5M3Z
2
?
A:
[51-395]
-----------------------------------------------------
L
E
E
S
G
Y
I
Y
T
R
L
G
N
P
T
-------
T
D
A
L
E
K
K
L
A
V
L
E
-------
R
G
E
A
G
L
-------
A
T
A
S
G
I
S
A
I
T
T
T
L
L
T
L
C
Q
Q
G
D
H
I
V
S
A
S
A
I
Y
G
H
T
H
A
F
L
S
H
S
M
P
K
F
-
G
I
N
V
S
F
V
D
A
A
-
K
P
-
E
E
I
R
A
A
M
R
-
P
E
T
K
V
V
Y
I
E
T
P
A
N
P
T
L
S
L
V
D
I
E
T
V
A
G
I
A
H
Q
Q
G
-
A
L
L
V
V
D
N
T
F
M
S
P
-
Y
C
Q
-
Q
P
L
Q
L
G
A
D
I
V
V
H
S
V
T
K
Y
I
N
G
H
G
D
V
I
G
G
I
I
----------------------------------
V
G
K
Q
E
F
I
D
Q
A
R
F
V
G
L
K
D
I
T
G
G
C
M
S
P
F
N
A
W
L
T
L
R
G
V
K
T
L
G
I
R
M
E
R
H
C
E
N
A
L
K
I
A
R
F
L
E
G
H
P
S
I
T
R
V
Y
Y
P
G
L
S
S
H
P
Q
Y
E
L
G
Q
R
Q
M
S
L
P
---
G
G
-
I
I
S
F
E
I
A
G
G
L
E
A
G
R
R
M
I
N
S
V
E
L
C
L
L
A
V
S
L
G
D
T
E
T
L
I
Q
H
P
A
S
M
T
H
S
P
V
A
P
E
E
R
L
K
A
G
I
T
D
G
L
I
R
L
S
V
G
L
E
D
P
E
D
I
I
N
D
L
E
H
A
I
R
K
-
6
PsiBlast_PDB
78.54
39%
-17
- C1 -
-
4HF8
5
?
A:
[51-395]
-----------------------------------------------------
L
E
E
S
G
Y
I
Y
T
R
L
G
N
P
T
-------
T
D
A
L
E
K
K
L
A
V
L
E
-------
R
G
E
A
G
L
-------
A
T
A
S
G
I
S
A
I
T
T
T
L
L
T
L
C
Q
Q
G
D
H
I
V
S
A
S
A
I
Y
G
C
T
H
A
F
L
S
H
S
M
P
K
F
-
G
I
N
V
R
F
V
D
A
A
-
K
P
-
E
E
I
R
A
A
M
R
-
P
E
T
K
V
V
Y
I
E
T
P
A
N
P
T
L
S
L
V
D
I
E
T
V
A
G
I
A
H
Q
Q
G
-
A
L
L
V
V
D
N
T
F
M
S
P
-
Y
C
Q
-
Q
P
L
Q
L
G
A
D
I
V
V
H
S
V
T
K
Y
I
N
G
H
G
D
V
I
G
G
I
I
----------------------------------
V
G
K
Q
E
F
I
D
Q
A
R
F
V
G
L
K
D
I
T
G
G
C
M
S
P
F
N
A
W
L
T
L
R
G
V
K
T
L
G
I
R
M
E
R
H
C
E
N
A
L
K
I
A
R
F
L
E
G
H
P
S
I
T
R
V
Y
Y
P
G
L
S
S
H
P
Q
Y
E
L
G
Q
R
Q
MS
L
P
---
G
G
-
I
I
S
F
E
I
A
G
G
L
E
A
G
R
R
M
I
N
S
V
E
L
C
L
L
A
V
S
L
G
D
T
E
T
L
I
Q
H
P
A
S
M
T
H
S
P
V
A
P
E
E
R
L
K
A
G
I
T
D
G
L
I
R
L
S
V
G
L
E
D
P
E
D
I
I
N
D
L
E
H
A
I
R
K
-
3
PsiBlast_PDB
76.27
39%
-14
- C1 -
-
5E4Z
3
?
A:
[51-395]
-----------------------------------------------------
L
E
E
S
G
Y
I
Y
T
R
L
G
N
P
T
-------
T
D
A
L
E
K
K
L
A
V
L
E
-------
R
G
E
A
G
L
-------
A
T
A
S
G
I
S
A
I
T
T
T
L
L
T
L
C
Q
Q
G
D
H
I
V
S
A
S
A
I
Y
G
A
T
H
A
F
L
S
H
S
M
P
K
F
-
G
I
N
V
S
F
V
D
A
A
-
K
P
-
E
E
I
R
A
A
M
R
-
P
E
T
K
V
V
Y
I
E
T
P
A
N
P
T
L
S
L
V
D
I
E
T
V
A
G
I
A
H
Q
Q
G
-
A
L
L
V
V
D
N
T
F
M
S
P
-
Y
C
Q
-
Q
P
L
Q
L
G
A
D
I
V
V
H
S
V
T
K
Y
I
N
G
H
G
D
V
I
G
G
I
I
----------------------------------
V
G
K
Q
E
F
I
D
Q
A
R
F
V
G
L
K
D
I
T
G
G
C
M
S
P
F
N
A
W
L
T
L
R
G
V
K
T
L
G
I
R
M
E
R
H
C
E
N
A
L
K
I
A
R
F
L
E
G
H
P
S
I
T
R
V
Y
Y
P
G
L
S
S
H
P
Q
Y
E
L
G
Q
R
Q
M
S
L
P
---
G
G
-
I
I
S
F
E
I
A
G
G
L
E
A
G
R
R
M
I
N
S
V
E
L
C
L
L
A
V
S
L
G
D
T
E
T
L
I
Q
H
P
A
S
M
T
H
S
P
V
A
P
E
E
R
L
K
A
G
I
T
D
G
L
I
R
L
S
V
G
L
E
D
P
E
D
I
I
N
D
L
E
H
A
I
R
K
-
101
PsiBlast_CBE
71.22
35%
-2
- C1 -
-
1PFF
18
?
A:
[1-328]
-----------------------------------------------------------------------------------
S
A
L
E
-------
G
K
I
A
K
L
E
HAE
A
C
A
A
T
A
S
G
M
G
A
I
A
A
S
V
W
T
F
L
K
A
G
D
H
L
I
S
D
D
C
L
Y
G
C
T
H
A
L
F
E
H
Q
L
R
K
F
-
G
V
E
V
D
F
I
D
M
A
-
V
P
-
G
N
I
E
K
H
L
K
-
P
N
T
R
I
V
Y
F
E
T
P
A
N
P
T
L
K
V
I
D
I
E
D
A
V
K
Q
A
R
K
Q
K
D
I
L
V
I
V
D
N
T
F
A
S
P
-
I
L
T
-
N
P
L
D
L
G
V
D
I
V
V
H
S
A
T
K
Y
I
N
G
H
T
D
V
V
A
G
L
V
C
S
R
----------------------------------
A
D
I
I
A
K
V
K
S
Q
G
I
K
D
I
T
G
A
I
I
S
P
H
D
A
W
L
I
T
R
G
T
L
T
L
D
M
R
V
K
R
A
A
E
N
A
Q
K
V
A
E
F
L
H
E
H
K
A
V
K
K
V
Y
Y
P
G
L
P
D
H
P
G
H
E
I
A
K
K
Q
--
M
-
K
M
F
G
S
-
M
I
A
F
D
V
D
G
-
L
E
K
A
K
K
V
L
D
N
C
H
V
V
S
L
A
V
S
L
G
G
P
E
S
L
I
Q
H
P
A
S
M
T
H
A
G
V
P
K
E
E
R
E
A
A
G
L
T
D
N
L
I
R
L
S
V
G
C
E
N
V
Q
D
I
I
D
D
L
K
Q
A
L
D
--