@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : spr1106: (2018-01-05 )
MLDLLKQTIFTRDFIFILILLGFILVVTLLLLENRRDNIQLKQINQKVKDLIAGDYSKVLDMQGGSEITNITNNLNDLSEVIRLTQENLEQESKRLNSILFYMTDGVLATNRRGQIIMINDTAKKQLGLVKEDVLNRSILELLKIEENYELRDLITQSPELLLDSQDINGEYLNLRVRFALIRRESGFISGLVAVLHDTTEQEKEERERRLFVSNVSHELRTPLTSVKSYLEALDEGALCETVAPDFIKVSLDETNRMMRMVTDLLHLSRIDNATSHLDVELINFTAFITFILNRFDKMKGQEKEKKYELVRDYPINSIWMEIDTDKMTQVVDNILNNAIKYSPDGGKITVRMKTTEDQMILSISDHGLGIPKQDLPRIFDRFYRVDRARSRAQGGTGLGLSIAKEIIKQHKGFIWAKSEYGKGSTFTIVLPYDKDAVKEEVWEDEVED
Atome Classification :
(28 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210-----........220.......230....--...240..-.......250.......260.......270.......280.......290.......--300-....-----.-----..310....-...320.......330.......340.----....---..350.......360...--....370.......380.......390.......400.......410.......420.......430.......440.......
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
M
L
D
L
L
K
Q
T
I
F
T
R
D
F
I
F
I
L
I
L
L
G
F
I
L
V
V
T
L
L
L
L
ENRRDNI
Q
L
K
Q
I
N
Q
K
V
K
D
L
I
AG
D
Y
S
K
V
LDMQGGS
E
I
T
N
I
TN
N
L
N
D
L
S
E
V
I
R
L
T
Q
E
N
L
E
Q
E
S
K
R
L
N
S
I
L
F
Y
MTD
G
V
LATNRRG
Q
I
I
M
IND
T
A
K
K
Q
LG
L
V
K
E
D
V
L
N
R
S
I
L
E
L
L
KIEENY
E
L
R
D
L
I
TQSPE
L
L
L
DSQDING
E
Y
L
N
L
R
V
R
F
A
L
I
RRES
G
F
I
S
G
L
V
A
V
LHDT
T
E
Q
E
K
E
E
R
E
R
R
L
------
F
V
S
NV
S
H
E
LRT
P
L
T
S
V
K
S
Y
L
E
ALDE--GAL
C
--
E
T-VAP
D
F
I
K
V
S
L
D
E
T
N
R
M
M
R
M
V
T
D
L
L
H
L
S
R
IDNATS
H
L
D
V
E
L
I
N
F
T
A
F
I
T
F
I
L
N
R
F
D
K
M--KG
Q
-
E
K
E
K
-----
K
-----
Y
E
L
V
R
DYPI-
N
S
I
W
M
E
I
D
T
D
K
M
T
Q
V
V
D
N
I
L
N
N
A
I
K
YS----PDG
G
---
K
I
T
V
R
M
KTTE
D
Q
M
I
L
S
IS--DHGLGI
P
K
Q
D
L
P
R
I
F
D
R
F
Y
R
V
D
R
A
R
SRAQGGTGL
G
L
S
I
A
K
E
I
I
K
QHK
G
F
I
W
A
KSEYGKG
S
T
F
T
I
V
L
PYD
K
D
A
V
K
E
E
V
W
E
D
EVED
47
HHSearch
87.83
66%
-
- C2 -
-
4I5S
-
?
B:
[28-434]
---------------------------
I
F
L
N
Y
R
E
Y
K
N
N
N
Q
V
K
Q
L
N
A
K
V
R
S
L
I
T
G
H
Y
T
D
K
L
K
V
E
D
N
S
D
L
S
E
L
V
N
N
V
N
D
L
S
E
V
F
R
L
T
H
E
N
L
A
Q
E
K
N
R
L
T
S
I
L
S
Y
M
T
D
G
V
L
A
T
D
R
S
G
K
I
T
V
I
N
D
M
A
Q
K
Q
L
N
V
T
R
E
Q
A
L
E
C
N
I
L
D
I
L
D
D
D
S
Y
T
Y
-
N
D
L
I
T
K
T
P
E
I
V
L
T
R
R
D
E
Y
D
E
F
I
T
L
R
I
R
F
A
L
N
R
R
E
S
G
F
I
S
G
L
I
A
V
L
H
D
A
T
E
Q
E
K
E
E
R
E
R
R
L
------
F
V
S
N
V
S
H
E
L
R
T
P
L
T
S
V
K
S
Y
L
E
A
L
D
D
--
G
A
L
T
--
E
S
-
V
A
P
S
F
I
K
V
S
L
D
E
T
N
R
M
M
R
M
I
T
D
L
L
S
L
S
R
I
D
N
Q
T
S
H
L
D
V
E
L
T
N
F
T
A
F
M
N
Y
I
L
D
R
F
D
Q
I
--
Q
S
Q
Q----------------
E
I
I
R
D
Y
P
D
-
K
S
V
W
I
E
I
D
T
D
K
M
T
Q
V
I
D
N
I
L
N
N
A
I
K
Y
S
----
P
D
G
G
---
K
V
T
I
T
M
Q
T
T
D
T
Q
L
I
L
S
I
S
--
D
Q
G
L
G
I
P
K
K
D
L
P
L
I
F
D
R
F
Y
R
V
D
K
A
R
------
T
G
L
G
L
A
I
A
K
E
I
V
K
Q
H
K
G
F
I
W
A
N
S
E
E
G
E
G
S
T
F
T
I
V
L
P
Y
E
---------------
1
PsiBlast_PDB
84.83
69%
-
- C2 -
-
4I5S
-
?
A:
[37-432]
------------------------------------
N
N
N
Q
V
K
Q
L
N
A
K
V
R
S
L
I
T
G
H
Y
T
D
K
L
K
V
E
D
N
S
D
L
S
E
L
V
N
N
V
N
D
L
S
E
V
F
R
L
T
H
E
N
L
A
Q
E
K
N
R
L
T
S
I
L
S
Y
M
T
D
G
V
L
A
T
D
R
S
G
K
I
T
V
I
N
D
M
A
Q
K
Q
L
N
V
T
R
E
Q
A
L
E
C
N
I
L
D
I
L
D
-
D
D
S
Y
T
Y
N
D
L
I
T
K
T
P
E
I
V
L
T
R
R
D
E
Y
D
E
F
I
T
L
R
I
R
F
A
L
N
R
R
E
S
G
F
I
S
G
L
I
A
V
L
H
D
A
T
E
Q
E
K
E
E
R
E
R
R
L
------
F
V
S
N
V
S
H
E
L
R
T
P
L
T
S
V
K
S
Y
L
E
A
L
D
D
--
G
A
L
T
--
E
S
-
V
A
P
S
F
I
K
V
S
L
D
E
T
N
R
M
M
R
M
I
T
D
L
L
S
L
S
R
-----
S
H
L
D
V
E
L
T
N
F
T
A
F
M
N
Y
I
L
D
R
F
D
Q
I
--
Q
S
Q
-
Q
S
T
-------------
E
I
I
R
D
Y
P
D
-
K
S
V
W
I
E
I
D
T
D
K
M
T
Q
V
I
D
N
I
L
N
N
A
I
K
Y
S
----
P
D
G
G
---
K
V
T
I
T
M
Q
T
T
D
T
Q
L
I
L
S
I
S
--
D
Q
G
L
G
I
P
K
K
D
L
P
L
I
F
D
R
F
Y
R
V
D
K
A
R
-------
G
L
G
L
A
I
A
K
E
I
V
K
Q
H
K
G
F
I
W
A
N
S
E
E
G
E
G
S
T
F
T
I
V
L
P
-----------------
70
Fugue
84.32
69%
-
- C2 -
-
4I5S
-
?
A:
[37-432]
------------------------------------
N
N
N
Q
V
K
Q
L
N
A
K
V
R
S
L
I
T
G
H
Y
T
D
K
L
K
V
E
D
N
S
D
L
S
E
L
V
N
N
V
N
D
L
S
E
V
F
R
L
T
H
E
N
L
A
Q
E
K
N
R
L
T
S
I
L
S
Y
M
T
D
G
V
L
A
T
D
R
S
G
K
I
T
V
I
N
D
M
A
Q
K
Q
L
N
V
T
R
E
Q
A
L
E
C
N
I
L
D
I
L
D
-
D
D
S
Y
T
Y
N
D
L
I
T
K
T
P
E
I
V
L
T
R
R
D
E
Y
D
E
F
I
T
L
R
I
R
F
A
L
N
R
R
E
S
G
F
I
S
G
L
I
A
V
L
H
D
A
T
E
Q
E
K
E
E
R
E
R
R
L
------
F
V
S
N
V
S
H
E
L
R
T
P
L
T
S
V
K
S
Y
L
E
A
L
D
D
--
G
A
L
T
--
E
S
-
V
A
P
S
F
I
K
V
S
L
D
E
T
N
R
M
M
R
M
I
T
D
L
L
S
L
S
R
-----
S
H
L
D
V
E
L
T
N
F
T
A
F
M
N
Y
I
L
D
R
F
D
Q
I
--
Q
----
S
Q
Q
-----
S
-----
T
E
I
I
R
D
Y
P
D
-
K
S
V
W
I
E
I
D
T
D
K
M
T
Q
V
I
D
N
I
L
N
N
A
I
K
Y
S
----
P
D
G
G
---
K
V
T
I
T
M
Q
T
T
D
T
Q
L
I
L
S
I
S
--
D
Q
G
L
G
I
P
K
K
D
L
P
L
I
F
D
R
F
Y
R
V
D
K
A
R
-------
G
L
G
L
A
I
A
K
E
I
V
K
Q
H
K
G
F
I
W
A
N
S
E
E
G
E
G
S
T
F
T
I
V
L
P
-----------------
5
PsiBlast_PDB
59.31
54%
34
- C2 -
-
5C93
1
?
A:
[3-241]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
T
E
Q
Q
K
I
D
N
D
R
K
Q
------
F
V
S
N
V
S
H
E
L
R
T
P
L
T
S
L
R
S
Y
I
E
A
L
S
D
--
G
A
W
K
--
D
P
E
V
A
P
G
F
L
K
V
T
Q
E
E
T
D
R
M
I
R
M
I
N
E
L
L
S
L
S
R
M
D
S
G
T
T
R
V
D
M
E
L
V
N
I
N
E
M
F
N
Y
V
L
D
R
F
D
M
I
L
K
K
D
D
-
N
P
A
K
-----
Y
-----
Y
T
I
K
R
E
F
T
K
-
R
D
L
W
V
E
I
D
T
D
K
F
T
Q
V
L
D
N
I
M
N
N
A
I
K
Y
S
----
P
D
G
G
---
V
V
T
C
R
L
L
E
T
H
N
Q
V
I
I
S
I
S
--
D
Q
G
L
G
I
P
R
A
D
L
G
H
V
F
D
R
F
F
R
V
D
K
A
----
Q
G
G
T
G
L
G
L
A
I
S
K
E
V
V
Q
M
L
G
G
R
I
W
V
D
S
V
E
G
K
G
S
T
F
Y
I
S
L
P
Y
E
---------------
52
HHSearch
59.13
56%
38
- C2 -
-
5C93
1
?
A:
[3-241]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
T
E
Q
Q
K
I
D
N
D
R
K
Q
------
F
V
S
N
V
S
H
E
L
R
T
P
L
T
S
L
R
S
Y
I
E
A
L
S
D
--
G
A
W
K
D-
P
E
-
V
A
P
G
F
L
K
V
T
Q
E
E
T
D
R
M
I
R
M
I
N
E
L
L
S
L
S
R
M
D
S
G
T
T
R
V
D
M
E
L
V
N
I
N
E
M
F
N
Y
V
L
D
R
F
-----
D
M
I
-
L
K
K
D
DNPA
K
Y
-----
Y
T
I
K
R
E
F
T
K
-
R
D
L
W
V
E
I
D
T
D
K
F
T
Q
V
L
D
N
I
M
N
N
A
I
K
Y
S
----
P
D
G
G
---
V
V
T
C
R
L
L
E
T
H
N
Q
V
I
I
S
I
S
--
D
Q
G
L
G
I
P
R
A
D
L
G
H
V
F
D
R
F
F
R
V
D
K
A
----
Q
G
G
T
G
L
G
L
A
I
S
K
E
V
V
Q
M
L
G
G
R
I
W
V
D
S
V
E
G
K
G
S
T
F
Y
I
S
L
P
Y
E
---------------
51
HHSearch
58.45
54%
38
- C2 -
-
4U7O
1
?
A:
[25-263]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
T
E
Q
Q
K
I
D
N
D
R
K
Q
------
F
V
S
N
V
S
H
E
L
R
T
P
L
T
S
L
R
S
Y
I
E
A
L
S
D
--
G
A
W
K
D-
P
E
-
V
A
P
G
F
L
K
V
T
Q
E
E
T
D
R
M
I
R
M
I
N
E
L
L
S
L
S
R
M
D
S
G
T
T
R
V
D
M
E
L
V
N
I
N
E
M
F
N
Y
V
L
D
R
F
-----
D
M
I
-
L
K
K
D
-----
D
NPA
K
Y
Y
T
I
K
R
E
F
T
K
-
R
D
L
W
V
E
I
D
T
D
K
F
T
Q
V
L
D
N
I
M
N
N
A
I
K
Y
S
----
P
D
G
G
---
V
V
T
C
R
L
L
E
T
H
N
Q
V
I
I
S
I
S
--
D
Q
G
L
G
I
P
R
A
D
L
G
H
V
F
D
R
F
F
R
V
D
K
-----
Q
G
G
T
G
L
G
L
A
I
S
K
E
V
V
Q
M
L
G
G
R
I
W
V
D
S
V
E
G
K
G
S
T
F
Y
I
S
L
P
Y
E
---------------
3
PsiBlast_PDB
57.82
53%
39
- C2 -
-
4U7O
1
?
A:
[25-263]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
T
E
Q
Q
K
I
D
N
D
R
K
Q
------
F
V
S
N
V
S
H
E
L
R
T
P
L
T
S
L
R
S
Y
I
E
A
L
S
D
--
G
A
W
K
--
D
P
E
V
A
P
G
F
L
K
V
T
Q
E
E
T
D
R
M
I
R
M
I
N
E
L
L
S
L
S
R
M
D
S
G
T
T
R
V
D
M
E
L
V
N
I
N
E
M
F
N
Y
V
L
D
R
F
D
M
I
L
K
K
D
D
-
N
P
A
K
-----
Y
-----
Y
T
I
K
R
E
F
T
K
-
R
D
L
W
V
E
I
D
T
D
K
F
T
Q
V
L
D
N
I
M
N
N
A
I
K
Y
S
----
P
D
G
G
---
V
V
T
C
R
L
L
E
T
H
N
Q
V
I
I
S
I
S
--
D
Q
G
L
G
I
P
R
A
D
L
G
H
V
F
D
R
F
F
R
V
D
K
-----
Q
G
G
T
G
L
G
L
A
I
S
K
E
V
V
Q
M
L
G
G
R
I
W
V
D
S
V
E
G
K
G
S
T
F
Y
I
S
L
P
Y
E
---------------
4
PsiBlast_PDB
57.37
53%
39
- C2 -
-
4ZKI
-
?
A:
[25-263]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
T
E
Q
Q
K
I
D
N
D
R
K
Q
------
F
V
S
N
V
S
H
E
L
R
T
P
L
T
S
L
R
S
Y
I
E
A
L
S
D
--
G
A
W
K
--
D
P
E
V
A
P
G
F
L
K
V
T
Q
E
E
T
D
R
M
I
R
M
I
N
E
L
L
S
L
S
R
M
D
S
G
T
T
R
V
D
M
E
L
V
N
I
N
E
M
F
N
Y
V
L
D
R
F
D
M
I
L
K
K
D
--
N
P
A
K
-----
Y
-----
Y
T
I
K
R
E
F
T
K
-
R
D
L
W
V
E
I
D
T
D
K
F
T
Q
V
L
D
N
I
M
N
N
A
I
K
Y
S
----
P
D
G
G
---
V
V
T
C
R
L
L
E
T
H
N
Q
V
I
I
S
I
S
--
D
Q
G
L
G
I
P
R
A
D
L
G
H
V
F
D
R
F
F
R
V
D
K
-----
Q
G
G
T
G
L
G
L
A
I
S
K
E
V
V
Q
M
L
G
G
R
I
W
V
D
S
V
E
G
K
G
S
T
F
Y
I
S
L
P
Y
E
---------------
23
PsiBlast_CBE
51.62
54%
37
- C2 -
-
5C93
1
?
B:
[14-241]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
Q
------
F
V
S
N
V
S
H
E
L
R
T
P
L
T
S
L
R
S
Y
I
E
A
L
S
D
--
G
A
W
K
--
D
P
E
V
A
P
G
F
L
K
V
T
Q
E
E
T
D
R
M
I
R
M
I
N
E
L
L
S
L
S
R
-----
T
R
V
D
M
E
L
V
N
I
N
E
M
F
N
Y
V
L
D
R
F
D
M
I
L
K
K
D
D
-
N
P
A
K
-----
Y
-----
Y
T
I
K
R
E
F
T
K
-
R
D
L
W
V
E
I
D
T
D
K
F
T
Q
V
L
D
N
I
M
N
N
A
I
K
Y
S
----
P
D
G
G
---
V
V
T
C
R
L
L
E
T
H
N
Q
V
I
I
S
I
S
--
D
Q
G
L
G
I
P
R
A
D
L
G
H
V
F
D
R
F
F
R
V
D
K
A
R
S
--
Q
G
G
T
G
L
G
L
A
I
S
K
E
V
V
Q
M
L
G
G
R
I
W
V
D
S
V
E
G
K
G
S
T
F
Y
I
S
L
P
Y
E
---------------
13
PsiBlast_PDB
50.27
41%
-171
- C1 -
-
4MN5
-
WALK_STAAU
A:
[15-121]
---------------------------------------------------------------------------------------------
R
R
L
D
S
V
I
T
H
M
S
D
G
I
I
A
T
D
R
R
G
R
I
R
I
V
N
D
M
A
L
K
M
L
G
M
A
K
E
D
I
I
G
Y
Y
M
L
S
V
L
S
L
E
D
E
F
K
L
E
E
I
Q
E
N
N
D
S
F
L
L
D
L
----
G
--
L
I
A
R
V
N
F
S
T
I
V
Q
E
T
G
F
V
T
G
Y
I
A
V
L
H
D
V
T
E
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
PsiBlast_CBE
50.25
53%
34
- C2 -
-
4U7O
1
?
B:
[37-263]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
------
F
V
S
N
V
S
H
E
L
R
T
P
L
T
S
L
R
S
Y
I
E
A
L
S
D
--
G
A
W
K
--
D
P
E
V
A
P
G
F
L
K
V
T
Q
E
E
T
D
R
M
I
R
M
I
N
E
L
L
S
L
S
------
T
R
V
D
M
E
L
V
N
I
N
E
M
F
N
Y
V
L
D
R
F
D
M
I
L
K
K
D
D
-
N
P
A
K
-----
Y
-----
Y
T
I
K
R
E
F
T
K
-
R
D
L
W
V
E
I
D
T
D
K
F
T
Q
V
L
D
N
I
M
N
N
A
I
K
Y
S
----
P
D
G
G
---
V
V
T
C
R
L
L
E
T
H
N
Q
V
I
I
S
I
S
--
D
Q
G
L
G
I
P
R
A
D
L
G
H
V
F
D
R
F
F
R
V
D
K
A
R
---
Q
G
G
T
G
L
G
L
A
I
S
K
E
V
V
Q
M
L
G
G
R
I
W
V
D
S
V
E
G
K
G
S
T
F
Y
I
S
L
P
Y
E
---------------
53
HHSearch
50.20
31%
-112
- C2 -
-
4BIX
-
CPXA_ECOLI
B:
[82-296]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
------
L
L
S
D
I
S
H
E
L
R
T
P
L
T
R
L
Q
L
G
T
A
L
L
R
R
--
R
S
G
E
-------
S
K
E
L
E
R
I
E
T
E
A
Q
R
L
D
S
M
I
N
D
L
L
V
M
S
R
N
Q
Q
K
N
-
A
L
V
S
E
T
I
K
A
N
Q
L
W
S
E
V
L
D
N
A
-----
A
F
E
-
A
E
Q
M
-----
G
-----
K
S
L
T
V
N
F
P
P
-
G
P
W
P
L
Y
G
N
P
N
A
L
E
S
A
L
E
N
I
V
R
N
A
L
R
Y
S
----
H
T
-----
K
I
E
V
G
F
A
V
D
K
D
G
I
T
I
T
V
D
--
D
D
G
P
G
V
S
P
E
D
R
E
Q
I
F
R
P
F
Y
R
T
D
--------
G
T
G
L
G
L
A
I
V
E
T
A
I
Q
Q
H
R
G
W
V
K
A
E
D
S
P
L
G
G
L
R
L
V
I
W
L
P
L
Y
K
--------------
72
Fugue
49.96
25%
-118
* C2 *
-
1ID0
1
A:
[1-146]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
E
L
H
P
V
A
P
L
L
D
N
L
T
S
A
L
--
N
K
V
-
Y
Q
R
K
-----
G
-----
V
N
I
S
L
D
I
S
--
P
E
I
S
F
V
G
E
Q
N
D
F
V
E
V
M
G
N
V
L
D
N
A
C
K
Y
C
----
L
E
-----
F
V
E
I
S
A
R
Q
T
D
E
H
L
Y
I
V
V
E
--
D
D
G
P
G
I
P
L
S
K
R
E
V
I
F
D
R
G
Q
R
V
D
T
L
R
P
----
G
Q
G
V
G
L
A
V
A
R
E
I
T
E
Q
Y
E
G
K
I
V
A
G
E
S
M
L
G
G
A
R
M
E
V
I
F
G
R
Q
H
--------------
21
PsiBlast_CBE
49.43
53%
34
- C2 -
-
4ZKI
1
?
B:
[37-263]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
------
F
V
S
N
V
S
H
E
L
R
T
P
L
T
S
L
R
S
Y
I
E
A
L
S
D
--
G
A
W
K
--
D
P
E
V
A
P
G
F
L
K
V
T
Q
E
E
T
D
R
M
I
R
M
I
N
E
L
L
S
---------
R
V
D
M
E
L
V
N
I
N
E
M
F
N
Y
V
L
D
R
F
D
M
I
L
K
K
D
-----
K
-----
Y
-----
Y
T
I
K
R
E
F
T
K
-
R
D
L
W
V
E
I
D
T
D
K
F
T
Q
V
L
D
N
I
M
N
N
A
I
K
Y
S
----
P
D
G
G
---
V
V
T
C
R
L
L
E
T
H
N
Q
V
I
I
S
I
S
--
D
Q
G
L
G
I
P
R
A
D
L
G
H
V
F
D
R
F
F
R
V
D
K
-----
Q
G
G
T
G
L
G
L
A
I
S
K
E
V
V
Q
M
L
G
G
R
I
W
V
D
S
V
E
G
K
G
S
T
F
Y
I
S
L
P
Y
E
---------------
50
HHSearch
49.16
31%
-99
- C2 -
-
4BIV
2
CPXA_ECOLI
A:
[82-296]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
------
L
L
S
D
I
S
H
E
L
R
T
P
L
T
R
L
Q
L
G
T
A
L
L
R
R
--
R
S
G
E
-------
S
K
E
L
E
R
I
E
T
E
A
Q
R
L
D
S
M
I
N
D
L
L
V
M
S
R
N
Q
Q
K
N
-
A
L
V
S
E
T
I
K
A
N
Q
L
W
S
E
V
L
D
N
A
-----
A
F
E
-
A
E
Q
M
-----
G
-----
K
S
L
T
V
N
F
P
P
-
G
P
W
P
L
Y
G
N
P
N
A
L
E
S
A
L
E
N
I
V
R
N
A
L
R
Y
S
----
H
T
-----
K
I
E
V
G
F
A
V
D
K
D
G
I
T
I
T
V
D
--
D
D
G
P
G
V
S
P
E
D
R
E
Q
I
F
R
P
F
Y
R
T
D
E
A
R
D
R
E
S
G
G
T
G
L
G
L
A
I
V
E
T
A
I
Q
Q
H
R
G
W
V
K
A
E
D
S
P
L
G
G
L
R
L
V
I
W
L
P
L
Y
K
--------------
17
PsiBlast_PDB
49.09
29%
-79
- C2 -
-
5LFK
2
?
A:
[54-296]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
G
P
Q
E
F
L
A
A
G
A
S
F
N
Q
V
V
T
A
L
E
R
M
M
T
S
Q
Q
R
------
L
L
S
D
I
S
H
E
L
R
T
P
L
T
R
L
Q
-
L
G
T
A
L
L
R
--
R
R
S
G
--
E
S
-
K
E
L
E
R
I
E
T
---
E
A
Q
R
L
D
S
M
I
N
D
L
L
V
M
S
R
-
N
Q
Q
K
N
A
L
V
S
E
T
I
K
A
N
Q
L
W
S
E
V
L
---
D
N
A
--
A
F
E
-
A
E
Q
M
-----
G
-----
K
S
L
T
V
N
F
P
P
-
G
P
W
P
L
Y
G
N
P
N
A
L
E
S
A
L
E
N
I
V
R
N
A
L
R
Y
S
----
H
T
-----
K
I
E
V
G
F
A
V
D
K
D
G
I
T
I
T
V
D
--
D
D
G
P
G
V
S
P
E
D
R
E
Q
I
F
R
P
F
Y
R
T
D
E
A
R
D
R
E
S
G
G
T
G
L
G
L
A
I
V
E
T
A
I
Q
Q
H
R
G
W
V
K
A
E
D
S
P
L
G
G
L
R
L
V
I
W
L
P
L
Y
K
--------------
20
PsiBlast_PDB
49.01
29%
-86
- C2 -
-
4BIZ
1
CPXA_ECOLI
A:
[62-296]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
G
A
S
F
N
Q
M
V
T
A
L
E
R
M
M
T
S
Q
Q
R
------
L
L
S
D
I
S
E
E
L
R
T
P
L
T
R
L
Q
-
L
G
T
A
L
L
R
--
R
R
S
G
--
E
S
-
K
E
L
E
R
I
E
T
---
E
A
Q
R
L
D
S
M
I
N
D
L
L
V
M
S
R
-
N
Q
Q
K
N
A
L
V
S
E
T
I
K
A
N
Q
L
W
S
E
V
L
---
D
N
A
--
A
F
E
-
A
E
Q
M
-----
G
-----
K
S
L
T
V
N
F
P
P
-
G
P
W
P
L
Y
G
N
P
N
A
L
E
S
A
L
E
N
I
V
R
N
A
L
R
Y
S
----
H
T
-----
K
I
E
V
G
F
A
V
D
K
D
G
I
T
I
T
V
D
--
D
D
G
P
G
V
S
P
E
D
R
E
Q
I
F
R
P
F
Y
R
T
D
E
A
R
D
R
E
--
G
T
G
L
G
L
A
I
V
E
T
A
I
Q
Q
H
R
G
W
V
K
A
E
D
S
P
L
G
G
L
R
L
V
I
W
L
P
L
Y
K
--------------
6
PsiBlast_PDB
48.83
48%
-67
- C2 -
-
3SL2
1
A:
[3-153]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
Q
I
V
R
F
M
S
L
I
I
D
R
F
E
M
T
--
K
-----
E
Q
------------
E
F
I
R
N
L
P
D
-
R
D
L
Y
V
E
I
D
Q
D
K
I
T
Q
V
L
D
N
I
I
S
N
A
L
K
Y
S
----
P
E
G
G
---
H
V
T
F
S
I
D
V
N
E
E
E
E
L
L
Y
I
S
V
K
D
E
G
I
G
I
P
K
K
D
V
E
K
V
F
D
R
F
Y
R
V
D
------
L
G
G
T
G
L
G
L
A
I
A
K
E
M
V
Q
A
H
G
G
D
I
W
A
D
S
I
E
G
K
G
T
T
I
T
F
T
L
P
Y
K
E
--------------
15
PsiBlast_PDB
48.57
29%
-100
- C2 -
-
4BIX
1
CPXA_ECOLI
A:
[61-296]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
A
G
A
S
F
N
Q
V
V
T
A
L
E
R
M
M
T
S
Q
Q
R
------
L
L
S
D
I
S
H
E
L
R
T
P
L
T
R
L
Q
-
L
G
T
A
L
L
R
--
R
R
S
G
--
E
S
-
K
E
L
E
R
I
E
T
---
E
A
Q
R
L
D
S
M
I
N
D
L
L
V
M
S
R
-
N
Q
Q
K
N
A
L
V
S
E
T
I
K
A
N
Q
L
W
S
E
V
L
---
D
N
A
--
A
F
E
-
A
E
Q
M
-----
G
-----
K
S
L
T
V
N
F
P
P
-
G
P
W
P
L
Y
G
N
P
N
A
L
E
S
A
L
E
N
I
V
R
N
A
L
R
Y
S
----
H
T
-----
K
I
E
V
G
F
A
V
D
K
D
G
I
T
I
T
V
D
--
D
D
G
P
G
V
S
P
E
D
R
E
Q
I
F
R
P
F
Y
R
T
D
--------
G
T
G
L
G
L
A
I
V
E
T
A
I
Q
Q
H
R
G
W
V
K
A
E
D
S
P
L
G
G
L
R
L
V
I
W
L
P
L
Y
K
--------------
2
PsiBlast_PDB
47.80
53%
-
- C2 -
-
4U7N
-
?
A:
[386-610]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
S
N
V
S
H
E
L
R
T
P
L
T
S
L
R
S
Y
I
E
A
L
S
D
--
G
A
W
K
--
D
P
E
V
A
P
G
F
L
K
V
T
Q
E
E
T
D
R
M
I
R
M
I
N
E
L
L
S
L
S
R
M
D
S
G
T
T
R
V
D
M
E
L
V
N
I
N
E
M
F
N
Y
V
L
D
R
F
D
M
I
L
K
K
D
D
-
N
--------
Y
-----
Y
T
I
K
R
E
F
T
K
-
R
D
L
W
V
E
I
D
T
D
K
F
T
Q
V
L
D
N
I
M
N
N
A
I
K
Y
S
----
P
D
G
G
---
V
V
T
C
R
L
L
E
T
H
N
Q
V
I
I
S
I
S
--
D
Q
G
L
G
I
P
R
A
D
L
G
H
V
F
D
R
F
F
R
-----------
T
G
L
G
L
A
I
S
K
E
V
V
Q
M
L
G
G
R
I
W
V
D
S
V
E
G
K
G
S
T
F
Y
I
S
L
P
Y
E
---------------
7
PsiBlast_PDB
47.71
32%
27
- C2 -
-
2C2A
1
?
A:
[1-249]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
V
T
E
S
K
E
L
E
R
L
K
R
I
D
R
M
K
T
E
F
I
A
N
I
S
H
E
L
R
T
P
L
T
A
I
K
A
Y
A
E
T
I
Y
N
S
L
G
E
L
D
--
L
S
-
T
L
K
E
F
L
E
V
I
I
D
Q
S
N
H
L
E
N
L
L
N
E
L
L
D
F
S
R
L
E
R
K
S
L
Q
I
N
R
E
K
V
D
L
C
D
L
V
E
S
A
V
N
A
I
K
E
F
--
A
S
S
-
H
N
V
N
-----
V
L
----
F
E
S
N
V
P
C
P
V
-
E
A
Y
---
I
D
P
T
R
I
R
Q
V
L
L
N
L
L
N
N
G
V
K
Y
S
KKDA
P
D
K
----
Y
V
K
V
I
L
D
E
K
D
G
G
V
L
I
I
V
E
--
D
N
G
I
G
I
P
D
H
A
K
D
R
I
F
E
Q
F
Y
R
V
D
---------
T
G
L
G
L
A
I
T
K
E
I
V
E
L
H
G
G
R
I
W
V
E
S
E
V
G
K
G
S
R
F
F
V
W
I
P
K
D
R
--------------
9
PsiBlast_PDB
47.33
32%
25
- C2 -
-
4JAV
1
?
A:
[3-248]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
V
T
E
S
K
E
L
E
R
L
K
R
I
D
R
M
K
T
E
F
I
A
N
I
S
H
E
L
R
T
P
L
T
A
I
K
A
Y
A
E
T
I
Y
N
S
L
G
E
L
D
--
L
S
-
T
L
K
E
F
L
E
V
I
I
D
Q
S
N
H
L
E
N
L
L
N
E
L
L
D
F
S
R
L
E
R
K
S
L
Q
I
N
R
E
K
V
D
L
C
D
L
V
E
S
A
V
N
A
I
K
E
F
--
A
S
S
-
H
N
V
N
-----
V
L
----
F
E
S
N
V
P
C
P
V
-
E
A
Y
---
I
D
P
T
R
I
R
Q
V
L
L
N
L
L
N
N
G
V
K
Y
S
KKDA
P
D
K
----
Y
V
K
V
I
L
D
E
K
D
G
G
V
L
I
I
V
E
--
D
N
G
I
G
I
P
D
H
A
K
D
R
I
F
E
Q
F
Y
R
V
D
S
S
L
T
Y
E
V
P
G
T
G
L
G
L
A
I
T
K
E
I
V
E
L
H
G
G
R
I
W
V
E
S
E
V
G
K
G
S
R
F
F
V
W
I
P
K
D
---------------
11
PsiBlast_PDB
45.48
32%
21
- C2 -
-
4JAU
1
?
A:
[7-247]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
K
E
L
E
R
L
K
R
I
D
R
M
K
T
E
F
I
A
N
I
S
H
E
L
R
T
P
L
T
V
I
K
G
Y
A
E
M
I
Y
N
S
L
G
E
L
D
--
L
S
-
T
L
K
E
F
L
E
T
I
I
E
Q
S
N
H
L
E
N
L
L
N
E
L
L
D
F
S
R
L
E
R
K
S
L
Q
I
N
R
E
K
V
D
L
C
D
L
V
E
S
A
V
N
A
I
K
E
F
--
A
S
S
-
H
N
V
N
-----
V
L
----
F
E
S
N
V
P
C
P
V
-
E
A
Y
---
I
D
P
T
R
I
R
Q
V
L
L
N
L
L
N
N
G
V
K
Y
S
KKDA
P
D
K
----
Y
V
K
V
I
L
D
E
K
D
G
G
V
L
I
I
V
E
--
D
N
G
I
G
I
P
D
H
A
K
D
R
I
F
E
Q
F
Y
R
V
D
S
---------
G
L
G
L
A
I
T
K
E
I
V
E
L
H
G
G
R
I
W
V
E
S
E
V
G
K
G
S
R
F
F
V
W
I
P
K
----------------
8
PsiBlast_PDB
44.85
32%
27
- C2 -
-
3DGE
2
?
A:
[14-249]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
R
I
D
R
M
K
T
E
F
I
A
N
I
S
H
E
L
R
T
P
L
T
A
I
K
A
Y
A
E
T
I
Y
N
S
L
G
E
L
D
--
L
S
-
T
L
K
E
F
L
E
V
I
I
D
Q
S
N
H
L
E
N
L
L
N
E
L
L
D
F
S
R
L
E
R
K
S
L
Q
I
N
R
E
K
V
D
L
C
D
L
V
E
S
A
V
N
A
I
K
E
F
--
A
S
S
-
H
N
V
N
-----
V
L
----
F
E
S
N
V
P
C
P
V
-
E
A
Y
---
I
D
P
T
R
I
R
Q
V
L
L
N
L
L
N
N
G
V
K
Y
S
KKDA
P
D
K
----
Y
V
K
V
I
L
D
E
K
D
G
G
V
L
I
I
V
E
--
D
N
G
I
G
I
P
D
H
A
K
D
R
I
F
E
Q
F
Y
R
V
D
S
S
L
T
Y
E
V
P
G
T
G
L
G
L
A
I
T
K
E
I
V
E
L
H
G
G
R
I
W
V
E
S
E
V
G
K
G
S
R
F
F
V
W
I
P
K
D
R
--------------
10
PsiBlast_PDB
43.82
32%
17
- C2 -
-
4JAS
1
?
A:
[13-249]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
R
I
D
R
M
K
T
E
F
I
A
N
I
S
H
E
L
R
T
P
L
T
V
I
K
G
Y
A
E
M
I
Y
N
S
L
G
E
L
D
--
L
S
-
T
L
K
E
F
L
E
T
I
I
E
Q
S
N
H
L
E
N
L
L
N
E
L
L
D
F
S
R
L
E
R
K
S
L
Q
I
N
R
E
K
V
D
L
C
D
L
V
E
S
A
V
N
A
I
K
E
F
--
A
S
S
-
H
N
V
N
-----
V
L
----
F
E
S
N
V
P
C
P
V
-
E
A
Y
---
I
D
P
T
R
I
R
Q
V
L
L
N
L
L
N
N
G
V
K
Y
S
KKDA
P
D
K
----
Y
V
K
V
I
L
D
E
K
D
G
G
V
L
I
I
V
E
--
D
N
G
I
G
I
P
D
H
A
K
D
R
I
F
E
Q
F
Y
R
V
D
S
S
L
T
Y
E
V
P
G
T
G
L
G
L
A
I
T
K
E
I
V
E
L
H
G
G
R
I
W
V
E
S
E
V
G
K
G
S
R
F
F
V
W
I
P
K
D
R
--------------
25
PsiBlast_CBE
43.53
32%
29
- C2 -
-
3DGE
1
?
B:
[14-249]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
R
I
DRMKTE
F
I
A
N
I
S
H
E
L
R
T
P
L
T
A
I
K
A
Y
A
E
T
I
Y
N
SL
G
E
L
D
--
L
S
-
T
L
K
E
F
L
E
V
I
I
D
Q
S
N
H
L
E
N
L
L
N
E
L
L
D
F
S
R
L
E
R
K
S
L
Q
I
N
R
E
K
V
D
L
C
D
L
V
E
S
A
V
N
A
I
K
E
F
--
A
S
S
-
H
N
V
N
-----
V
L----
F
E
S
N
V
P
C
P
V
-
E
A
Y
---
I
D
P
T
R
I
R
Q
V
L
L
N
L
L
N
N
G
V
K
Y
S
KKDA
P
D
K
----
Y
V
K
V
I
L
D
E
K
D
G
G
V
L
I
I
V
E
--
D
N
G
I
G
I
P
D
H
A
K
D
R
I
F
E
Q
F
Y
R
V
D
S
S
L
T
Y
E
V
P
G
T
G
L
G
L
A
I
T
K
E
I
V
E
L
H
G
G
R
I
W
V
E
S
E
V
G
K
G
S
R
F
F
V
W
I
P
K
D
R
--------------
58
HHSearch
40.43
32%
82
- C2 -
-
2C2A
1
?
A:
[17-249]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
R
M
K
T
E
------
F
I
A
N
I
S
H
E
L
R
T
P
L
T
A
I
K
A
Y
A
E
T
I
Y
N
--
S
L
G
E
LD
L
S
-
T
L
K
E
F
L
E
V
I
I
D
Q
S
N
H
L
E
N
L
L
N
E
L
L
D
F
S
R
L
E
R
K
S
L
Q
I
N
R
E
K
V
D
L
C
D
L
V
E
S
A
V
N
A
I
-----
K
E
F
-
A
S
S
H
-----
N
-----
V
N
V
L
F
E
S
N
V
P
C
P
V
E
A
Y
I
D
P
T
R
I
R
Q
V
L
L
N
L
L
N
N
G
V
K
Y
S
----
K
K
D
A
P
D
K
Y
V
K
V
I
L
D
E
K
D
G
G
V
L
I
I
V
E
--
D
N
G
I
G
I
P
D
H
A
K
D
R
I
F
E
Q
F
Y
R
V
D
---------
T
G
L
G
L
A
I
T
K
E
I
V
E
L
H
G
G
R
I
W
V
E
S
E
V
G
K
G
S
R
F
F
V
W
I
P
K
D
R
--------------
57
HHSearch
39.46
32%
78
- C2 -
-
4JAV
1
?
A:
[18-248]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
M
K
T
E
------
F
I
A
N
I
S
H
E
L
R
T
P
L
T
A
I
K
A
Y
A
E
T
I
Y
N
--
S
L
G
E
LD
L
S
-
T
L
K
E
F
L
E
V
I
I
D
Q
S
N
H
L
E
N
L
L
N
E
L
L
D
F
S
R
L
E
R
K
S
L
Q
I
N
R
E
K
V
D
L
C
D
L
V
E
S
A
V
N
A
I
-----
K
E
F
-
A
S
S
H
-----
N
-----
V
N
V
L
F
E
S
N
V
P
C
P
V
E
A
Y
I
D
P
T
R
I
R
Q
V
L
L
N
L
L
N
N
G
V
K
Y
S
----
K
K
D
A
P
D
K
Y
V
K
V
I
L
D
E
K
D
G
G
V
L
I
I
V
E
--
D
N
G
I
G
I
P
D
H
A
K
D
R
I
F
E
Q
F
Y
R
V
D
S
S
L
T
Y
E
V
P
G
T
G
L
G
L
A
I
T
K
E
I
V
E
L
H
G
G
R
I
W
V
E
S
E
V
G
K
G
S
R
F
F
V
W
I
P
K
D
---------------