@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : spr1108: (2018-01-05 )
MLDLKEYGIVMWPEEKVISFREKLLAWYDENKRDLPWRRSKNPYHIWVSEIMLQQTRVDTVIPYYERFLDWFPTVESLATAPEESLLKAWEGLGYYSRVRNMQAAAQQIMTDFGGQFPNTYEGISSLKGIGPYTAGAISSIAFNLPEPAVDGNVMRVLARLFEVNHDIGIPSNRKIFQAMMEILINPDRPGDFNQALMDLGSDIESPVNPRPEESPVKDFSAAYQNGTMDRYPIKSPKKKPVPIYLKALVVKNSQGQFLLEKNESEKLLAGFWHFPFIEVDNFSQEEQFDLFHQVAEESVNFGPSPEESFQQDYDLDVDWLDVCFDTVQHVFSHRKWHVQIVAGQVSDFHDFSDREVRWLSPEEFKNYPLAKPQQKIWQAYAQANLDSSQD
Atome Classification :
(27 SA)
.........10........20........30...-......40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170....---...180.------......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.-......370.......380.......390
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MLD
L
K
EY
G
I
V
MW
P
E
E
K
V
I
S
F
R
E
K
L
L
A
W
Y
DE-NKR-DLPWRRSKNP
Y
H
I
W
V
S
E
I
M
L
Q
QTRV
D
T
V
I
P
Y
Y
E
R
F
L
D
W
F
P
T
V
E
S
L
ATA
P
E
E
S
L
L
K
A
W
EGL
G
Y
Y
S
R
V
R
N
M
Q
A
A
A
Q
Q
I
M
T
D
FGGQFP
N
T
Y
E
G
I
S
SLKGIGPYTA
G
A
I
S
S
I
AFNLPEPAVD
G
N
V
M
R
V
L
A
R
L
F
EVNHDIGIPSN
R
K
I
---
F
Q
A
M
M
E
I
------LINPDRPG
D
F
N
Q
A
L
M
D
LG
S
D
IESPVNPRPEESP
V
K
D
F
S
A
A
YQNGTMDRYPIKSPKKKPV
P
I
Y
L
K
A
L
V
V
KNSQG
Q
F
L
L
EKNES
E
K
L
L
A
G
FWHF
P
F
I
EVDNFS
Q
E
E
Q
F
D
L
F
H
Q
V
A
E
E
SVNFGPS
P
E
E
S
F
Q
QDYDL
D
V
D
W
L
D
V
C
F
D
T
V
Q
H
V
F
SHR
K
W
H
V
Q
I
V
AGQVSDFHDFSDR
E
V
R
WL
S
P
E
-
E
FKNYPLA
K
P
Q
Q
K
I
W
Q
A
Y
A
Q
ANLDSSQD
31
HHSearch
86.92
41%
-97
* C3 *
-
3G0Q
3
MUTY_GEOSE
A:
[3-350]
-----------------
R
E
F
Q
R
D
L
L
D
W
F
A
R
-
E
R
R
-
D
L
P
W
R
K
D
R
D
P
Y
K
V
W
V
S
E
V
M
L
Q
Q
T
R
V
E
T
V
I
P
Y
F
E
Q
F
I
D
R
F
P
T
L
E
A
L
A
D
A
D
E
D
E
V
L
K
A
W
E
G
L
G
Y
Y
S
R
V
R
N
L
H
A
A
V
K
E
V
K
T
R
Y
G
G
K
V
P
D
D
P
D
E
F
S
R
L
K
G
V
G
P
Y
T
V
G
A
V
L
S
L
A
Y
G
V
P
E
P
A
V
D
G
N
V
M
R
V
L
S
R
L
F
L
V
T
D
D
I
A
K
C
S
T
R
K
R
---
F
E
Q
I
V
R
E
------
I
M
A
Y
E
N
P
G
A
F
N
E
A
L
I
E
L
G
A
L
V
C
T
P
R
R
P
S
C
L
L
C
P
V
Q
A
Y
C
Q
A
F
A
E
G
V
A
E
E
L
P
V
K
M
----
V
K
Q
V
P
L
A
V
A
V
L
A
D
D
E
G
R
V
L
I
R
K
R
D
S
T
G
L
L
A
N
L
W
E
F
P
S
C
E
T
D
-
G
A
D
G
K
E
K
L
E
Q
----------------
M
V
----
G
L
Q
V
E
L
-
T
E
P
I
V
S
F
E
H
A
F
S
H
L
V
W
Q
L
T
V
F
P
G
R
L
V
H
G
-
G
P
V
E
E
P
Y
R
L
A
P
E
D
-
E
L
K
A
Y
A
F
P
V
S
H
Q
R
V
W
R
E
Y
K
E
W
-------
9
PsiBlast_PDB
86.05
40%
-91
- C3 -
-
4YPR
5
MUTY_GEOSE
A:
[16-360]
-------------------
F
Q
R
D
L
L
D
W
F
A
R
-
E
R
R
-
D
L
P
W
R
K
D
R
D
P
Y
K
V
W
V
S
E
V
M
L
Q
Q
T
R
V
E
T
V
I
P
Y
F
E
Q
F
I
D
R
F
P
T
L
E
A
L
A
D
A
D
E
D
E
V
L
K
A
W
E
G
L
G
Y
Y
S
R
V
R
N
L
H
A
A
V
K
E
V
K
T
R
Y
G
G
K
V
P
D
D
P
D
E
F
S
R
L
K
G
V
G
P
Y
T
V
G
A
V
L
S
L
A
Y
G
V
P
E
P
A
V
N
G
N
V
M
R
V
L
S
R
L
F
L
V
T
D
D
I
A
K
C
S
T
R
K
R
---
F
E
Q
I
V
R
E
------
I
M
A
Y
E
N
P
G
A
F
N
E
A
L
I
E
L
G
A
L
V
C
T
P
R
R
P
S
C
L
L
C
P
V
Q
A
Y
C
Q
A
F
A
E
G
V
A
E
E
L
P
V
K
M
K
K
T
A
V
K
Q
V
P
L
A
V
A
V
L
A
D
D
E
G
R
V
L
I
R
K
R
D
S
T
G
L
L
A
N
L
W
E
F
P
S
C
E
T
D
G
A
D
G
K
E
K
L
-----------------
E
Q
M
V
G
E
Q
Y
G
L
Q
V
E
-
L
T
E
P
I
V
S
F
E
H
A
F
S
H
L
V
W
Q
L
T
V
F
P
G
R
L
--
V
H
G
G
P
V
E
E
P
Y
R
L
A
P
E
D
E
L
K
A
Y
A
F
P
V
S
H
Q
R
V
W
R
E
Y
K
E
--------
55
Fugue
86.03
40%
-92
- C3 -
-
1RRQ
3
MUTY_GEOSE
A:
[12-362]
---------------
P
A
R
E
F
Q
R
D
L
L
D
W
F
A
R
-
E
R
R
-
D
L
P
W
R
K
D
R
D
P
Y
K
V
W
V
S
E
V
M
L
Q
Q
T
R
V
E
T
V
I
P
Y
F
E
Q
F
I
D
R
F
P
T
L
E
A
L
A
D
A
D
E
D
E
V
L
K
A
W
E
G
L
G
Y
Y
S
R
V
R
N
L
H
A
A
V
K
E
V
K
T
R
Y
G
G
K
V
P
D
D
P
D
E
F
S
R
L
K
G
V
G
P
Y
T
V
G
A
V
L
S
L
A
Y
G
V
P
E
P
A
V
N
G
N
V
M
R
V
L
S
R
L
F
L
V
T
D
D
I
A
K
C
S
T
R
K
R
---
F
E
Q
I
V
R
E
------
I
M
A
Y
E
N
P
G
A
F
N
E
A
L
I
E
L
G
A
L
V
C
T
P
R
R
P
S
C
L
L
C
P
V
Q
A
Y
C
Q
A
F
A
E
G
V
A
E
E
L
P
V
K
M
V
K
Q
V
P
L
A
V
A
V
L
A
D
----
D
E
G
R
V
L
I
R
K
R
D
S
T
G
L
L
A
N
L
W
E
F
P
S
C
E
T
D
G
A
D
G
K
E
K
L
E
Q
M
V
G
L
Q
V
E
L
T
E
P
----------------------
I
V
S
F
E
H
A
F
S
H
L
V
W
Q
L
T
V
F
P
G
R
L
V
H
G
G
P
-
V
E
E
P
Y
R
L
A
P
E
D
-
E
L
K
A
Y
A
F
P
V
S
H
Q
R
V
W
R
E
Y
K
E
W
A
------
2
PsiBlast_PDB
85.21
41%
-93
- C3 -
-
3FSP
3
MUTY_GEOSE
A:
[16-360]
-------------------
F
Q
R
D
L
L
D
W
F
A
R
-
E
R
R
-
D
L
P
W
R
K
D
R
D
P
Y
K
V
W
V
S
E
V
M
L
Q
Q
T
R
V
E
T
V
I
P
Y
F
E
Q
F
I
D
R
F
P
T
L
E
A
L
A
D
A
D
E
D
E
V
L
K
A
W
E
G
L
G
Y
Y
S
R
V
R
N
L
H
A
A
V
K
E
V
K
T
R
Y
G
G
K
V
P
D
D
P
D
E
F
S
R
L
K
G
V
G
P
Y
T
V
G
A
V
L
S
L
A
Y
G
V
P
E
P
A
V
D
G
N
V
M
R
V
L
S
R
L
F
L
V
T
D
D
I
A
K
P
S
T
R
K
R
---
F
E
Q
I
V
R
E
------
I
M
A
Y
E
N
P
G
A
F
N
E
A
L
I
E
L
G
A
L
V
C
T
P
R
R
P
S
C
L
L
C
P
V
Q
A
Y
C
Q
A
F
A
E
G
V
A
E
E
L
P
V
K
M
K
K
T
A
V
K
Q
V
P
L
A
V
A
V
L
A
D
D
E
G
R
V
L
I
R
K
R
D
S
T
G
L
L
A
N
L
W
E
F
P
S
C
E
T
D
G
A
D
G
K
E
K
L
-----------------
E
Q
M
V
G
E
Q
Y
G
L
Q
V
E
-
L
T
E
P
I
V
S
F
E
H
A
F
S
H
L
V
W
Q
L
T
V
F
P
G
R
L
--
V
H
G
G
P
V
E
E
P
Y
R
L
A
P
E
D
E
L
K
A
Y
A
F
P
V
S
H
Q
R
V
W
R
E
Y
K
E
--------
8
PsiBlast_PDB
85.12
40%
-91
- C3 -
-
1RRQ
3
MUTY_GEOSE
A:
[16-360]
-------------------
F
Q
R
D
L
L
D
W
F
A
R
-
E
R
R
-
D
L
P
W
R
K
D
R
D
P
Y
K
V
W
V
S
E
V
M
L
Q
Q
T
R
V
E
T
V
I
P
Y
F
E
Q
F
I
D
R
F
P
T
L
E
A
L
A
D
A
D
E
D
E
V
L
K
A
W
E
G
L
G
Y
Y
S
R
V
R
N
L
H
A
A
V
K
E
V
K
T
R
Y
G
G
K
V
P
D
D
P
D
E
F
S
R
L
K
G
V
G
P
Y
T
V
G
A
V
L
S
L
A
Y
G
V
P
E
P
A
V
N
G
N
V
M
R
V
L
S
R
L
F
L
V
T
D
D
I
A
K
C
S
T
R
K
R
---
F
E
Q
I
V
R
E
------
I
M
A
Y
E
N
P
G
A
F
N
E
A
L
I
E
L
G
A
L
V
C
T
P
R
R
P
S
C
L
L
C
P
V
Q
A
Y
C
Q
A
F
A
E
G
V
A
E
E
L
P
V
K
M
----
V
K
Q
V
P
L
A
V
A
V
L
A
D
D
E
G
R
V
L
I
R
K
R
D
S
T
G
L
L
A
N
L
W
E
F
P
S
C
E
T
D
G
A
D
G
K
E
K
L
-----------------
E
Q
M
V
----
G
L
Q
V
E
-
L
T
E
P
I
V
S
F
E
H
A
F
S
H
L
V
W
Q
L
T
V
F
P
G
R
L
--
V
H
G
G
P
V
E
E
P
Y
R
L
A
P
E
D
E
L
K
A
Y
A
F
P
V
S
H
Q
R
V
W
R
E
Y
K
E
--------
7
PsiBlast_PDB
85.05
40%
-94
- C3 -
-
4YPH
3
MUTY_GEOSE
A:
[16-360]
-------------------
F
Q
R
D
L
L
D
W
F
A
R
-
E
R
R
-
D
L
P
W
R
K
D
R
D
P
Y
K
V
W
V
S
E
V
M
L
Q
Q
T
R
V
E
T
V
I
P
Y
F
E
Q
F
I
D
R
F
P
T
L
E
A
L
A
D
A
D
E
D
E
V
L
K
A
W
E
G
L
G
Y
Y
S
R
V
R
N
L
H
A
A
V
K
E
V
K
T
R
Y
G
G
K
V
P
D
D
P
D
E
F
S
R
L
K
G
V
G
P
Y
T
V
G
A
V
L
S
L
A
Y
G
V
P
E
P
A
V
D
G
N
V
M
R
V
L
S
R
L
F
L
V
T
D
D
I
A
K
C
S
T
R
K
R
---
F
E
Q
I
V
R
E
------
I
M
A
Y
E
N
P
G
A
F
N
E
A
L
I
E
L
G
A
L
V
C
T
P
R
R
P
S
C
L
L
C
P
V
Q
A
Y
C
Q
A
F
A
E
G
V
A
E
E
L
P
V
K
M
----
V
K
Q
V
P
L
A
V
A
V
L
A
D
D
E
G
R
V
L
I
R
K
R
D
S
T
G
L
L
A
N
L
W
E
F
P
S
C
E
T
D
G
A
D
G
K
E
K
L
-----------------
E
Q
M
V
----
G
L
Q
V
E
-
L
T
E
P
I
V
S
F
E
H
A
F
S
H
L
V
W
Q
L
T
V
F
P
G
R
L
--
V
H
G
G
P
V
E
E
P
Y
R
L
A
P
E
D
E
L
K
A
Y
A
F
P
V
S
H
Q
R
V
W
R
E
Y
K
E
--------
1
PsiBlast_PDB
84.76
41%
-91
- C3 -
-
5DPK
3
MUTY_GEOSE
A:
[13-357]
-------------------
F
Q
R
D
L
L
D
W
F
A
R
-
E
R
R
-
D
L
P
W
R
K
D
R
D
P
Y
K
V
W
V
S
E
V
M
L
Q
Q
T
R
V
E
T
V
I
P
Y
F
E
Q
F
I
D
R
F
P
T
L
E
A
L
A
D
A
D
E
D
E
V
L
K
A
W
E
G
L
G
Y
Y
S
R
V
R
N
L
H
A
A
V
K
E
V
K
T
R
Y
G
G
K
V
P
D
D
P
D
E
F
S
R
L
K
G
V
G
P
Y
T
V
G
A
V
L
S
L
A
Y
G
V
P
E
P
A
V
D
G
N
V
M
R
V
L
S
R
L
F
L
V
T
D
D
I
A
K
P
S
T
R
K
R
---
F
E
Q
I
V
R
E
------
I
M
A
Y
E
N
P
G
A
F
N
E
A
L
I
E
L
G
A
L
V
C
T
P
R
R
P
S
C
L
L
C
P
V
Q
A
Y
C
Q
A
F
A
E
G
V
A
E
E
L
P
V
K
M
K
K
T
A
V
K
Q
V
P
L
A
V
A
V
L
A
D
D
E
G
R
V
L
I
R
K
R
D
S
T
G
L
L
A
N
L
W
E
F
P
S
C
E
T
D
G
A
D
G
K
E
K
L
-----------------
E
Q
M
V
G
E
Q
-----
E
-
L
T
E
P
I
V
S
F
E
H
A
F
S
H
L
V
W
Q
L
T
V
F
P
G
R
L
--
V
H
G
G
P
V
E
E
P
Y
R
L
A
P
E
D
E
L
K
A
Y
A
F
P
V
S
H
Q
R
V
W
R
E
Y
K
E
--------
6
PsiBlast_PDB
84.62
40%
-90
- C3 -
-
4YOQ
4
MUTY_GEOSE
A:
[16-360]
-------------------
F
Q
R
D
L
L
D
W
F
A
R
-
E
R
R
-
D
L
P
W
R
K
D
R
D
P
Y
K
V
W
V
S
E
V
M
L
Q
Q
T
R
V
E
T
V
I
P
Y
F
E
Q
F
I
D
R
F
P
T
L
E
A
L
A
D
A
D
E
D
E
V
L
K
A
W
E
G
L
G
Y
Y
S
R
V
R
N
L
H
A
A
V
K
E
V
K
T
R
Y
G
G
K
V
P
D
D
P
D
E
F
S
R
L
K
G
V
G
P
Y
T
V
G
A
V
L
S
L
A
Y
G
V
P
E
P
A
V
D
G
N
V
M
R
V
L
S
R
L
F
L
V
T
D
D
I
A
K
C
S
T
R
K
R
---
F
E
Q
I
V
R
E
------
I
M
A
Y
E
N
P
G
A
F
N
E
A
L
I
E
L
G
A
L
V
C
T
P
R
R
P
S
C
L
L
C
P
V
Q
A
Y
C
Q
A
F
A
E
G
V
A
E
E
L
P
V
K
M
----
V
K
Q
V
P
L
A
V
A
V
L
A
D
D
E
G
R
V
L
I
R
K
R
D
S
T
G
L
L
A
N
L
W
E
F
P
S
C
E
T
D
G
A
D
G
K
E
K
L
-----------------
E
Q
M
V
----
G
L
Q
V
E
-
L
T
E
P
I
V
S
F
E
H
A
F
S
H
L
V
W
Q
L
T
V
F
P
G
R
L
--
V
H
G
G
P
V
E
E
P
Y
R
L
A
P
E
D
E
L
K
A
Y
A
F
P
V
S
H
Q
R
V
W
R
E
Y
K
E
--------
21
PsiBlast_CBE
84.18
40%
-87
- C3 -
-
4YPR
3
MUTY_GEOSE
B:
[16-360]
-------------------
F
Q
R
D
L
L
D
W
F
A
R
-
E
R
R
-
D
L
P
W
R
K
D
R
D
P
Y
K
V
W
V
S
E
V
M
L
Q
Q
T
R
V
E
T
V
I
P
Y
F
E
Q
F
I
D
R
F
P
T
L
E
A
L
A
D
A
D
E
D
E
V
L
K
A
W
E
G
L
G
Y
Y
S
R
V
R
N
L
H
A
A
V
K
E
V
K
T
R
Y
G
G
K
V
P
D
D
P
D
E
F
S
R
L
K
G
V
G
P
Y
T
V
G
A
V
L
S
L
A
Y
G
V
P
E
P
A
V
N
G
N
V
M
R
V
L
S
R
L
F
L
V
T
D
D
I
A
K
C
S
T
R
K
R
---
F
E
Q
I
V
R
E
------
I
M
A
Y
E
N
P
G
A
F
N
E
A
L
I
E
L
G
A
L
V
C
T
P
R
R
P
S
C
L
L
C
P
V
Q
A
Y
C
Q
A
F
A
E
G
V
A
E
E
L
P
V
K
M
K
K
T
A
V
K
Q
V
P
L
A
V
A
V
L
A
D
D
E
G
R
V
L
I
R
K
R
D
S
T
G
L
L
A
N
L
W
E
F
P
S
C
E
T
D
G
A
D
G
K
E
K
L
-----------------
E
Q
M
V
G
-----
Q
V
E
-
L
T
E
P
I
V
S
F
E
H
A
F
S
H
L
V
W
Q
L
T
V
F
P
G
R
L
--
V
H
G
G
P
V
E
E
P
Y
R
L
A
P
E
D
E
L
K
A
Y
A
F
P
V
S
H
Q
R
V
W
R
E
Y
K
E
--------
5
PsiBlast_PDB
83.95
40%
-89
- C3 -
-
3G0Q
3
MUTY_GEOSE
A:
[5-349]
-------------------
F
Q
R
D
L
L
D
W
F
A
R
-
E
R
R
-
D
L
P
W
R
K
D
R
D
P
Y
K
V
W
V
S
E
V
M
L
Q
Q
T
R
V
E
T
V
I
P
Y
F
E
Q
F
I
D
R
F
P
T
L
E
A
L
A
D
A
D
E
D
E
V
L
K
A
W
E
G
L
G
Y
Y
S
R
V
R
N
L
H
A
A
V
K
E
V
K
T
R
Y
G
G
K
V
P
D
D
P
D
E
F
S
R
L
K
G
V
G
P
Y
T
V
G
A
V
L
S
L
A
Y
G
V
P
E
P
A
V
D
G
N
V
M
R
V
L
S
R
L
F
L
V
T
D
D
I
A
K
C
S
T
R
K
R
---
F
E
Q
I
V
R
E
------
I
M
A
Y
E
N
P
G
A
F
N
E
A
L
I
E
L
G
A
L
V
C
T
P
R
R
P
S
C
L
L
C
P
V
Q
A
Y
C
Q
A
F
A
E
G
V
A
E
E
L
P
V
K
M
----
V
K
Q
V
P
L
A
V
A
V
L
A
D
D
E
G
R
V
L
I
R
K
R
D
S
T
G
L
L
A
N
L
W
E
F
P
S
C
E
T
D
G
A
D
G
K
E
K
L
-----------------
E
Q
M
V
----
G
L
Q
V
E
-
L
T
E
P
I
V
S
F
E
H
A
F
S
H
L
V
W
Q
L
T
V
F
P
G
R
L
--
V
H
G
G
P
V
E
E
P
Y
R
L
A
P
E
D
E
L
K
A
Y
A
F
P
V
S
H
Q
R
V
W
R
E
Y
K
E
--------
3
PsiBlast_PDB
83.77
40%
-90
- C3 -
-
1RRS
3
MUTY_GEOSE
A:
[16-360]
-------------------
F
Q
R
D
L
L
D
W
F
A
R
-
E
R
R
-
D
L
P
W
R
K
D
R
D
P
Y
K
V
W
V
S
E
V
M
L
Q
Q
T
R
V
E
T
V
I
P
Y
F
E
Q
F
I
D
R
F
P
T
L
E
A
L
A
D
A
D
E
D
E
V
L
K
A
W
E
G
L
G
Y
Y
S
R
V
R
N
L
H
A
A
V
K
E
V
K
T
R
Y
G
G
K
V
P
D
D
P
D
E
F
S
R
L
K
G
V
G
P
Y
T
V
G
A
V
L
S
L
A
Y
G
V
P
E
P
A
V
N
G
N
V
M
R
V
L
S
R
L
F
L
V
T
D
D
I
A
K
P
S
T
R
K
R
---
F
E
Q
I
V
R
E
------
I
M
A
Y
E
N
P
G
A
F
N
E
A
L
I
E
L
G
A
L
V
C
T
P
R
R
P
S
C
L
L
C
P
V
Q
A
Y
C
Q
A
F
A
E
G
V
A
E
E
L
P
V
K
M
K
---
V
K
Q
V
P
L
A
V
A
V
L
A
D
D
E
G
R
V
L
I
R
K
R
D
S
T
G
L
L
A
N
L
W
E
F
P
S
C
E
T
D
G
A
D
G
K
E
K
L
-----------------
E
Q
M
V
----
G
L
Q
V
E
-
L
T
E
P
I
V
S
F
E
H
A
F
S
H
L
V
W
Q
L
T
V
F
P
G
R
L
--
V
H
G
G
P
V
E
E
P
Y
R
L
A
P
E
D
E
L
K
A
Y
A
F
P
V
S
H
Q
R
V
W
R
E
Y
K
E
--------
4
PsiBlast_PDB
82.98
40%
-95
- C3 -
-
1VRL
4
MUTY_GEOSE
A:
[16-360]
-------------------
F
Q
R
D
L
L
D
W
F
A
R
-
E
R
R
-
D
L
P
W
R
K
D
R
D
P
Y
K
V
W
V
S
E
V
M
L
Q
Q
T
R
V
E
T
V
I
P
Y
F
E
Q
F
I
D
R
F
P
T
L
E
A
L
A
D
A
D
E
D
E
V
L
K
A
W
E
G
L
G
Y
Y
S
R
V
R
N
L
H
A
A
V
K
E
V
K
T
R
Y
G
G
K
V
P
D
D
P
D
E
F
S
R
L
K
G
V
G
P
Y
T
V
G
A
V
L
S
L
A
Y
G
V
P
E
P
A
V
N
G
N
V
M
R
V
L
S
R
L
F
L
V
T
D
D
I
A
K
P
S
T
R
K
R
---
F
E
Q
I
V
R
E
------
I
M
A
Y
E
N
P
G
A
F
N
E
A
L
I
E
L
G
A
L
V
C
T
P
R
R
P
S
C
L
L
C
P
V
Q
A
Y
C
Q
A
F
A
E
G
V
A
E
E
L
P
V
K
M
K
K
T
A
V
K
Q
V
P
L
A
V
A
V
L
A
D
D
E
G
R
V
L
I
R
K
R
D
S
T
G
L
L
A
N
L
W
E
F
P
S
C
E
T
D
--
D
G
K
E
K
L
-----------------
E
Q
M
V
----
G
L
Q
V
E
-
L
T
E
P
I
V
S
F
E
H
A
F
S
H
L
V
W
Q
L
T
V
F
P
G
R
L
--
V
H
G
G
P
V
E
E
P
Y
R
L
A
P
E
D
E
L
K
A
Y
A
F
P
V
S
H
Q
R
V
W
R
E
Y
K
E
--------
35
HHSearch
79.36
48%
-105
- C3 -
-
5KN8
3
MUTY_GEOSE
A:
[11-231]
--------------
F
P
A
R
E
F
Q
R
D
L
L
D
W
F
A
R
-
E
R
R
-
D
L
P
W
R
K
D
R
D
P
Y
K
V
W
V
S
E
V
M
L
Q
Q
T
R
V
E
T
V
I
P
Y
F
E
Q
F
I
D
R
F
P
T
L
E
A
L
A
D
A
D
E
D
E
V
L
K
A
W
E
G
L
G
Y
Y
S
R
V
R
N
L
H
A
A
V
K
E
V
K
T
R
Y
G
G
K
V
P
D
D
P
D
E
F
S
R
L
K
G
V
G
P
Y
T
V
G
A
V
L
S
L
A
Y
G
V
P
E
P
A
V
N
G
N
V
M
R
V
L
S
R
L
F
L
V
T
D
D
I
A
K
C
S
T
R
K
R
---
F
E
Q
I
V
R
E
------
I
M
A
Y
E
N
P
G
A
F
N
E
A
L
I
E
L
G
A
L
V
C
T
P
R
R
P
S
C
L
L
C
P
V
Q
A
Y
C
Q
A
F
A
E
G
V
A
E
E
L
P
V
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
77.78
50%
-105
- C3 -
-
5KN8
3
MUTY_GEOSE
A:
[16-231]
-------------------
F
Q
R
D
L
L
D
W
F
A
R
-
E
R
R
-
D
L
P
W
R
K
D
R
D
P
Y
K
V
W
V
S
E
V
M
L
Q
Q
T
R
V
E
T
V
I
P
Y
F
E
Q
F
I
D
R
F
P
T
L
E
A
L
A
D
A
D
E
D
E
V
L
K
A
W
E
G
L
G
Y
Y
S
R
V
R
N
L
H
A
A
V
K
E
V
K
T
R
Y
G
G
K
V
P
D
D
P
D
E
F
S
R
L
K
G
V
G
P
Y
T
V
G
A
V
L
S
L
A
Y
G
V
P
E
P
A
V
N
G
N
V
M
R
V
L
S
R
L
F
L
V
T
D
D
I
A
K
C
S
T
R
K
R
---
F
E
Q
I
V
R
E
------
I
M
A
Y
E
N
P
G
A
F
N
E
A
L
I
E
L
G
A
L
V
C
T
P
R
R
P
S
C
L
L
C
P
V
Q
A
Y
C
Q
A
F
A
E
G
V
A
E
E
L
P
V
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
76.34
50%
-102
- C3 -
-
5KN9
3
MUTY_GEOSE
A:
[16-231]
-------------------
F
Q
R
D
L
L
D
W
F
A
R
-
E
R
R
-
D
L
P
W
R
K
D
R
D
P
Y
K
V
W
V
S
E
V
M
L
Q
Q
T
R
Y
E
T
V
I
P
Y
F
E
Q
F
I
D
R
F
P
T
L
E
A
L
A
D
A
D
E
D
E
V
L
K
A
W
E
G
L
G
Y
Y
S
R
V
R
N
L
H
A
A
V
K
E
V
K
T
R
Y
G
G
K
V
P
D
D
P
D
E
F
S
R
L
K
G
V
G
P
Y
T
V
G
A
V
L
S
L
A
Y
G
V
P
E
P
A
V
N
G
N
V
M
R
V
L
S
R
L
F
L
V
T
D
D
I
A
K
C
S
T
R
K
R
---
F
E
Q
I
V
R
E
------
I
M
A
Y
E
N
P
G
A
F
N
E
A
L
I
E
L
G
A
L
V
C
T
P
R
R
P
S
C
L
L
C
P
V
Q
A
Y
C
Q
A
F
A
E
G
V
A
E
E
L
P
V
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------
33
HHSearch
66.89
44%
-8
- C3 -
-
1KQJ
4
MUTY_ECOLI
A:
[3-224]
----------------
A
S
Q
F
S
A
Q
V
L
D
W
Y
D
K
-
Y
G
R
K
T
L
P
W
Q
I
D
K
T
P
Y
K
V
W
L
S
E
V
M
L
Q
Q
T
Q
V
A
T
V
I
P
Y
F
E
R
F
M
A
R
F
P
T
V
T
D
L
A
N
A
P
L
D
E
V
L
H
L
W
T
G
L
G
Y
Y
A
R
A
R
N
L
H
K
A
A
Q
Q
V
A
T
L
H
G
G
K
F
P
E
T
F
E
E
V
A
A
L
P
G
V
G
R
S
T
A
G
A
I
L
S
L
S
L
G
K
H
F
P
I
L
D
G
N
V
K
R
V
L
A
R
C
Y
A
V
S
G
W
P
G
K
K
E
V
E
N
K
---
L
W
S
L
S
E
Q
------
V
T
P
A
V
G
V
E
R
F
N
Q
A
M
M
D
L
G
A
M
I
C
T
R
S
K
P
K
H
S
L
C
P
L
Q
N
G
C
I
A
A
A
N
N
S
W
A
L
Y
P
G
K
K
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
66.88
43%
-30
- C3 -
-
1KG7
3
MUTY_ECOLI
A:
[6-224]
-------------------
F
S
A
Q
V
L
D
W
Y
D
K
Y
G
R
K
-
T
L
P
W
Q
I
D
K
T
P
Y
K
V
W
L
S
E
V
M
L
Q
Q
T
Q
V
A
T
V
I
P
Y
F
E
R
F
M
A
R
F
P
T
V
T
D
L
A
N
A
P
L
D
E
V
L
H
L
W
T
G
L
G
Y
Y
A
R
A
R
N
L
H
K
A
A
Q
Q
V
A
T
L
H
G
G
K
F
P
E
T
F
E
E
V
A
A
L
P
G
V
G
R
S
T
A
G
A
I
L
S
L
S
L
G
K
H
F
P
I
L
D
G
N
V
K
R
V
L
A
R
C
Y
A
V
S
---
G
W
P
G
K
K
E
V
---
A
N
K
L
W
S
L
S
E
Q
V
TP
A
V
G
V
E
R
---
F
N
Q
A
M
M
D
L
G
A
M
I
C
T
R
S
K
P
K
C
S
L
C
P
L
Q
N
G
C
I
A
A
A
N
N
S
W
A
L
Y
P
G
K
K
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------
23
PsiBlast_CBE
66.75
43%
-8
- C3 -
-
1KQJ
4
MUTY_ECOLI
A:
[6-225]
-------------------
F
S
A
Q
V
L
D
W
Y
D
K
Y
G
R
K
-
T
L
P
W
Q
I
D
K
T
P
Y
K
V
W
L
S
E
V
M
L
Q
Q
T
Q
V
A
T
V
I
P
Y
F
E
R
F
M
A
R
F
P
T
V
T
D
L
A
N
A
P
L
D
E
V
L
H
L
W
T
G
L
G
Y
Y
A
R
A
R
N
L
H
K
A
A
Q
Q
V
A
T
L
H
G
G
K
F
P
E
T
F
E
E
V
A
A
L
P
G
V
G
R
S
T
A
G
A
I
L
S
L
S
L
G
K
H
F
P
I
L
D
G
N
V
K
R
V
L
A
R
C
Y
A
V
S
---
G
W
P
G
K
K
E
V
E
N
K
L
W
S
L
S
E
Q
------
V
T
P
A
V
G
V
E
R
F
N
Q
A
M
M
D
L
G
A
M
I
C
T
R
S
K
P
K
H
S
L
C
P
L
Q
N
G
C
I
A
A
A
N
N
S
W
A
L
Y
P
G
K
K
P
K
----------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
66.56
43%
-8
- C3 -
-
1KG4
3
MUTY_ECOLI
A:
[6-224]
-------------------
F
S
A
Q
V
L
D
W
Y
D
K
Y
G
R
K
-
T
L
P
W
Q
I
D
K
T
P
Y
K
V
W
L
S
E
V
M
L
Q
Q
T
Q
V
A
T
V
I
P
Y
F
E
R
F
M
A
R
F
P
T
V
T
D
L
A
N
A
P
L
D
E
V
L
H
L
W
T
G
L
G
Y
Y
A
R
A
R
N
L
H
K
A
A
Q
Q
V
A
T
L
H
G
G
K
F
P
E
T
F
E
E
V
A
A
L
P
G
V
G
R
S
T
A
G
A
I
L
S
L
S
L
G
K
H
F
P
I
L
D
G
N
V
A
R
V
L
A
R
C
Y
A
V
S
---
G
W
P
G
K
K
E
V
E
N
K
L
W
S
L
S
E
Q
------
V
T
P
A
V
G
V
E
R
F
N
Q
A
M
M
D
L
G
A
M
I
C
T
R
S
K
P
K
C
S
L
C
P
L
Q
N
G
C
I
A
A
A
N
N
S
W
A
L
Y
P
G
K
K
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------
24
PsiBlast_CBE
66.48
44%
-7
- C3 -
-
1WEF
1
MUTY_ECOLI
A:
[6-225]
-------------------
F
S
A
Q
V
L
D
W
Y
D
K
-
Y
G
R
A
T
L
P
W
Q
I
D
K
T
P
Y
K
V
W
L
S
E
V
M
L
Q
Q
T
Q
V
A
T
V
I
P
Y
F
E
R
F
M
A
R
F
P
T
V
T
D
L
A
N
A
P
L
D
E
V
L
H
L
W
T
G
L
G
Y
Y
A
R
A
R
N
L
H
K
A
A
Q
Q
V
A
T
L
H
G
G
K
F
P
E
T
F
E
E
V
A
A
L
P
G
V
G
R
S
T
A
G
A
I
L
S
L
S
L
G
K
H
F
P
I
L
D
G
N
V
K
R
V
L
A
R
C
Y
A
V
S
---
G
W
P
G
K
K
E
V
E
N
K
L
W
S
L
S
E
Q
------
V
T
P
A
V
G
V
E
R
F
N
Q
A
M
M
D
L
G
A
M
I
C
T
R
S
K
P
K
C
S
L
C
P
L
Q
N
G
C
I
A
A
A
N
N
S
W
A
L
Y
P
G
K
K
P
K
----------------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
65.76
43%
-5
- C3 -
-
1KG5
5
MUTY_ECOLI
A:
[6-225]
-------------------
F
S
A
Q
V
L
D
W
Y
D
K
Y
G
R
K
-
T
L
P
W
Q
I
D
K
T
P
Y
K
V
W
L
S
E
V
M
L
Q
Q
T
Q
V
A
T
V
I
P
Y
F
E
R
F
M
A
R
F
P
T
V
T
D
L
A
N
A
P
L
D
E
V
L
H
L
W
T
G
L
G
Y
Y
A
R
A
R
N
L
H
K
A
A
Q
Q
V
A
T
L
H
G
G
K
F
P
E
T
F
E
E
V
A
A
L
P
G
V
G
R
S
T
A
G
A
I
L
S
L
S
L
G
K
H
F
P
I
L
D
G
N
V
Q
R
V
L
A
R
C
Y
A
V
S
---
G
W
P
G
K
K
E
V
E
N
K
L
W
S
L
S
E
Q
------
V
T
P
A
V
G
V
E
R
F
N
Q
A
M
M
D
L
G
A
M
I
C
T
R
S
K
P
K
C
S
L
C
P
L
Q
N
G
C
I
A
A
A
N
N
S
W
A
L
Y
P
G
K
K
P
K
----------------------------------------------------------------------------------------------------------------------------------------------------------
26
PsiBlast_CBE
65.47
43%
-5
- C3 -
-
1MUD
4
MUTY_ECOLI
A:
[6-225]
-------------------
F
S
A
Q
V
L
D
W
Y
D
K
Y
G
R
K
-
T
L
P
W
Q
I
D
K
T
P
Y
K
V
W
L
S
E
V
M
L
Q
Q
T
Q
V
A
T
V
I
P
Y
F
E
R
F
M
A
R
F
P
T
V
T
D
L
A
N
A
P
L
D
E
V
L
H
L
W
T
G
L
G
Y
Y
A
R
A
R
N
L
H
K
A
A
Q
Q
V
A
T
L
H
G
G
K
F
P
E
T
F
E
E
V
A
A
L
P
G
V
G
R
S
T
A
G
A
I
L
S
L
S
L
G
K
H
F
P
I
L
N
G
N
V
K
R
V
L
A
R
C
Y
A
V
S
---
G
W
P
G
K
K
E
V
E
N
K
L
W
S
L
S
E
Q
------
V
T
P
A
V
G
V
E
R
F
N
Q
A
M
M
D
L
G
A
M
I
C
T
R
S
K
P
K
C
S
L
C
P
L
Q
N
G
C
I
A
A
A
N
N
S
W
A
L
Y
P
G
K
K
P
K
----------------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
64.63
43%
-6
- C3 -
-
1WEG
4
MUTY_ECOLI
A:
[6-225]
-------------------
F
S
A
Q
V
L
D
W
Y
D
K
Y
G
R
K
-
T
L
P
W
Q
I
D
K
T
P
Y
K
V
W
L
S
E
V
M
L
Q
Q
T
Q
V
A
T
V
I
P
Y
F
E
R
F
M
A
R
F
P
T
V
T
D
L
A
N
A
P
L
D
E
V
L
H
L
W
T
G
L
G
Y
Y
A
R
A
R
N
L
H
K
A
A
Q
Q
V
A
T
L
H
G
G
K
F
P
E
T
F
E
E
V
A
A
L
P
G
V
G
R
S
T
A
G
A
I
L
S
L
S
L
G
K
H
F
P
I
L
D
G
N
V
A
R
V
L
A
R
C
Y
A
V
S
---
G
W
P
G
K
K
E
V
E
N
K
L
W
S
L
S
E
Q
------
V
T
P
A
V
G
V
E
R
F
N
Q
A
M
M
D
L
G
A
M
I
C
T
R
S
K
P
K
C
S
L
C
P
L
Q
N
G
C
I
A
A
A
N
N
S
W
A
L
Y
P
G
K
K
P
K
----------------------------------------------------------------------------------------------------------------------------------------------------------
25
PsiBlast_CBE
64.39
43%
-6
- C3 -
-
1MUN
7
MUTY_ECOLI
A:
[6-225]
-------------------
F
S
A
Q
V
L
D
W
Y
D
K
Y
G
R
K
-
T
L
P
W
Q
I
D
K
T
P
Y
K
V
W
L
S
E
V
M
L
Q
Q
T
Q
V
A
T
V
I
P
Y
F
E
R
F
M
A
R
F
P
T
V
T
D
L
A
N
A
P
L
D
E
V
L
H
L
W
T
G
L
G
Y
Y
A
R
A
R
N
L
H
K
A
A
Q
Q
V
A
T
L
H
G
G
K
F
P
E
T
F
E
E
V
A
A
L
P
G
V
G
R
S
T
A
G
A
I
L
S
L
S
L
G
K
H
F
P
I
L
N
G
N
V
K
R
V
L
A
R
C
Y
A
V
S
---
G
W
P
G
K
K
E
V
E
N
K
L
W
S
L
S
E
Q
------
V
T
P
A
V
G
V
E
R
F
N
Q
A
M
M
D
L
G
A
M
I
C
T
R
S
K
P
K
C
S
L
C
P
L
Q
N
G
C
I
A
A
A
N
N
S
W
A
L
Y
P
G
K
K
P
K
----------------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
63.96
43%
-5
- C3 -
-
1MUY
4
MUTY_ECOLI
A:
[6-225]
-------------------
F
S
A
Q
V
L
D
W
Y
D
K
Y
G
R
K
-
T
L
P
W
Q
I
D
K
T
P
Y
K
V
W
L
S
E
V
M
L
Q
Q
T
Q
V
A
T
V
I
P
Y
F
E
R
F
M
A
R
F
P
T
V
T
D
L
A
N
A
P
L
D
E
V
L
H
L
W
T
G
L
G
Y
Y
A
R
A
R
N
L
H
K
A
A
Q
Q
V
A
T
L
H
G
G
K
F
P
E
T
F
E
E
V
A
A
L
P
G
V
G
R
S
T
A
G
A
I
L
S
L
S
L
G
K
H
F
P
I
L
D
G
N
V
K
R
V
L
A
R
C
Y
A
V
S
---
G
W
P
G
K
K
E
V
E
N
K
L
W
S
L
S
E
Q
------
V
T
P
A
V
G
V
E
R
F
N
Q
A
M
M
D
L
G
A
M
I
C
T
R
S
K
P
K
C
S
L
C
P
L
Q
N
G
C
I
A
A
A
N
N
S
W
A
L
Y
P
G
K
K
P
K
----------------------------------------------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
63.94
43%
-10
- C3 -
-
1KG6
5
MUTY_ECOLI
A:
[6-224]
-------------------
F
S
A
Q
V
L
D
W
Y
D
K
Y
G
R
K
-
T
L
P
W
Q
I
D
K
T
P
Y
K
V
W
L
S
E
V
M
L
Q
Q
T
Q
V
A
T
V
I
P
Y
F
E
R
F
M
A
R
F
P
T
V
T
D
L
A
N
A
P
L
D
E
V
L
H
L
W
T
G
L
G
Y
Y
A
R
A
R
N
L
H
K
A
A
Q
Q
V
A
T
L
H
G
G
K
F
P
E
T
F
E
E
V
A
A
L
P
G
V
G
R
S
T
A
G
A
I
L
S
L
S
L
G
K
H
F
P
I
L
D
G
N
V
R
R
V
L
A
R
C
Y
A
V
S
---
G
W
P
G
K
K
E
V
E
N
K
L
W
S
L
S
E
Q
------
V
T
P
A
V
G
V
E
R
F
N
Q
A
M
M
D
L
G
A
M
I
C
T
R
S
K
P
K
C
S
L
C
P
L
Q
N
G
C
I
A
A
A
N
N
S
W
A
L
Y
P
G
K
K
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------
34
HHSearch
63.53
44%
-0
- C3 -
-
1MUN
7
MUTY_ECOLI
A:
[4-225]
-----------------
S
Q
F
S
A
Q
V
L
D
W
Y
D
K
-
Y
G
R
K
T
L
P
W
Q
I
D
K
T
P
Y
K
V
W
L
S
E
V
M
L
Q
Q
T
Q
V
A
T
V
I
P
Y
F
E
R
F
M
A
R
F
P
T
V
T
D
L
A
N
A
P
L
D
E
V
L
H
L
W
T
G
L
G
Y
Y
A
R
A
R
N
L
H
K
A
A
Q
Q
V
A
T
L
H
G
G
K
F
P
E
T
F
E
E
V
A
A
L
P
G
V
G
R
S
T
A
G
A
I
L
S
L
S
L
G
K
H
F
P
I
L
N
G
N
V
K
R
V
L
A
R
C
Y
A
V
S
G
W
P
G
K
K
E
V
E
N
K
---
L
W
S
L
S
E
Q
------
V
T
P
A
V
G
V
E
R
F
N
Q
A
M
M
D
L
G
A
M
I
C
T
R
S
K
P
K
C
S
L
C
P
L
Q
N
G
C
I
A
A
A
N
N
S
W
A
L
Y
P
G
K
K
P
K
----------------------------------------------------------------------------------------------------------------------------------------------------------