@TOME V2.3
(Mar 2018)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : spr1120: (2018-01-05 )
MKKKFLAFLLILFPIFSLGIAKAETIKIVSDTAYAPFEFKDSDQTYKGIDVDIINKVAEIKGWNIQMSYPGFDAAVNAVQAGQADAIMAGMTKTKEREKVFTMSDTYYDTKVVIATTKSHKISKYDQLTGKTVGVKNGTAAQRFLETIKDKYGFTIKTFDTGDLMNNSLSAGAIDAMMDDKPVIEYAINQGQDLHIEMDGEAVGSFAFGVKKGSKYEHLVTEFNQALSEMKKDGSLDKIIKKWTASSSSAVPTTTTLAGLKAIPVKAKYIIASDSSFAPFVFQNSSNQYTGIDMELIKAIAKDQGFEIEITNPGFDAAISAVQAGQADGIIAGMSVTDARKATFDFSESYYTANTILGVKESSNIASYEDLKGKTVGVKNGTASQTFLTENQSKYGYKIKTFADGSSMDDSLNTGAIDAVMDDEPVLKYSISQGQKLKTPISGTPIGETAFAVKKGANPELIEMFNNGLANLKANGEFQKILDKYLASESSTASTSTVDETTLWGLLQNNYKQLLSGLGITLALALISFAIAIVIGIIFGMFSVSPYKSLRVISEIFVDVIRGIPLMILAAFIFWGIPNFIESITGQQSPINDFVAGTIALSLNAAAYIAEIVRGGIQAVPVGQMEASRSLGISYGKTMRKIILPQVTKLMLPNFVNQFVIALKDTTIVSAIGLVELFQTGKIIIARNYQSFKMYAILAIFYLVIITLLTRLAKRLEKRIR
Atome Classification :
(20 SA)
-------.........10........20.......-.30........40........50........60.......-.70........80........90........100.......110.......-120.......130.......140.......150-.......160.......170.......180.......190......-.200---.......210.......220.......230.......240.......250.......260.-......---270.......280.......290.......300.......310-.......320.......330.......340.......350..-.....360-..-.-....370.......380.......390.......400.......410.......420.......430.......440..---.....450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
-------M
K
K
K
F
L
A
F
L
L
I
L
F
P
I
F
S
LGIAK
A
E
T
I
K
I
-VSDTAYAPFEFKDSDQTYKGI
D
V
D
I
I
N
K
V
A
EIKG
W
N
I
Q
M
S-YPG
F
D
A
A
V
N
A
V
QAGQ
A
D
A
I
M
AGMTKTKER
E
K
V
F
T
MSDTYYD
T
K
V
V
I
A
TTKS-HKI
S
K
Y
D
QLTG
K
T
VGVKN
G
T
A
A
Q
R
F
L
E
T
I
K
D
KY-
G
F
T
I
K
T
FDT
G
D
LMNNSLSAG
A
I
D
AMMDDK
P
V
I
E
Y
AINQG
Q
D
L
H
I
E
M-DGEA---V
G
S
F
A
FGVKKGS
K
Y
E
H
L
V
T
E
F
N
Q
A
L
S
E
M
KKDG
S
L
D
K
I
I
K
K
WTASSSSAVPT
T
T
T
LAG
L
K
AI-P
V
K
A
K
Y
---
I
I
ASDSSF
A
P
F
V
F
QNSSNQYTGI
D
M
E
L
I
K
A
I
A
KDQG
F
E
I
E
ITN-P
G
F
D
A
A
I
S
A
V
QAGQAD
G
I
I
AGMSVTDA
R
K
A
T
F
DFSESYYTA
N
-
T
I
L
GVKES-SN-I-ASYEDLKG
K
T
V
GVKNGTAS
Q
T
F
LTENQSKY
G
Y
K
I
K
T
FADGSSMDDSLNTGA
I
D
AVMDDEP
V
L
K
Y
SISQGQKLKTPISGT---PIGET
A
F
A
VKKGA
N
P
E
L
I
E
M
F
NNGLANLKANG
E
F
Q
K
I
L
D
K
Y
LASESSTASTSTV
D
E
T
T
L
W
G
L
L
Q
N
N
Y
K
Q
L
L
SGL
G
I
T
L
A
L
A
L
I
S
F
A
I
A
I
V
I
G
I
I
F
G
M
FSV
S
P
Y
K
S
L
R
V
I
S
E
I
F
V
D
V
IRG
I
P
L
M
I
L
A
A
F
I
F
WG
I
P
N
F
I
E
S
ITGQQSP
I
N
D
FV
A
G
T
I
A
L
SL
N
A
A
A
Y
I
A
E
I
V
RGGIQAVPVG
Q
M
E
A
S
R
SLG
I
S
Y
G
K
T
M
R
K
I
I
L
P
Q
V
T
K
L
M
L
P
N
F
V
N
Q
F
V
I
ALKD
T
T
I
V
S
A
I
G
L
V
E
L
F
QT
G
K
I
I
I
A
RN
Y
Q
S
F
K
M
Y
A
I
L
A
I
F
Y
L
V
I
I
T
L
L
T
R
L
A
K
R
L
E
K
RIR
1
PsiBlast_PDB
80.57
99%
-88
- C1 -
-
4OEN
-
?
A:
[4-223]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
Y
---
I
I
A
S
D
S
S
F
A
P
F
V
F
Q
N
S
S
N
Q
Y
T
G
I
D
M
E
L
I
K
A
I
A
K
D
Q
G
F
E
I
E
I
T
N
-
P
G
F
D
A
A
I
S
A
V
Q
A
G
Q
A
D
G
I
I
A
G
M
S
V
T
D
A
R
K
A
T
F
D
F
S
E
S
Y
Y
T
A
N
-
T
I
L
G
V
K
E
S
-
S
N
-
I
-
A
S
Y
E
D
L
K
G
K
T
V
G
V
K
N
G
T
A
S
Q
T
F
L
T
E
N
Q
S
K
Y
G
Y
K
I
K
T
F
A
D
G
S
S
M
Y
D
S
L
N
T
G
A
I
D
A
V
M
D
D
E
P
V
L
K
Y
S
I
S
Q
G
Q
K
L
K
T
P
I
S
G
T
---
P
I
G
E
T
A
F
A
V
K
K
G
A
N
P
E
L
I
E
M
F
N
N
G
L
A
N
L
K
A
N
G
E
F
Q
K
I
L
D
K
Y
L
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
67.44
58%
-7
- C1 -
-
4KQP
1
?
A:
[3-232]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
T
-
P
K
K
D
V
Y
---
T
I
A
S
D
N
S
F
A
P
F
E
F
Q
N
D
D
K
Q
F
T
G
I
D
V
D
L
L
N
A
I
A
K
N
Q
G
F
K
L
K
W
N
F
-
I
G
F
Q
A
A
V
D
S
V
Q
S
G
H
A
D
G
M
M
S
G
M
S
I
T
D
A
R
K
Q
V
F
D
Y
G
S
P
Y
Y
S
S
N
L
T
I
A
T
S
S
T
D
-
D
S
-
I
-
K
S
W
K
D
L
K
G
K
T
L
G
A
K
N
G
T
A
S
F
D
Y
L
N
A
H
A
K
E
Y
G
Y
T
V
K
T
F
T
D
A
T
T
M
Y
S
S
L
N
N
G
S
I
N
A
L
M
D
D
E
P
V
I
K
Y
A
I
K
Q
G
Q
K
F
A
T
P
I
K
P
I
---
P
D
G
Q
Y
G
F
A
V
K
K
G
S
N
P
E
L
I
E
M
F
N
N
G
L
A
N
L
R
A
N
G
E
Y
D
K
I
I
D
K
Y
L
E
S
D
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
PsiBlast_CBE
66.05
58%
-2
- C1 -
-
4KR5
3
?
B:
[3-232]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
T
-
P
K
K
D
V
Y
---
T
I
A
S
D
N
S
F
A
P
F
E
F
Q
N
D
D
K
Q
F
T
G
I
D
V
D
L
L
N
A
I
A
K
N
Q
G
F
K
L
K
W
N
F
-
I
G
F
Q
A
A
V
D
S
V
Q
S
G
H
A
D
G
M
M
S
G
M
S
I
T
D
A
R
K
Q
V
F
D
Y
G
S
P
Y
Y
S
S
N
L
T
I
A
T
S
S
T
D
-
D
S
-
I
-
K
S
W
K
D
L
K
G
K
T
L
G
A
K
N
G
T
A
S
F
D
Y
L
N
A
H
A
K
E
Y
G
Y
T
V
K
T
F
T
D
A
T
T
M
Y
S
S
L
N
N
G
S
I
N
A
L
M
D
D
E
P
V
I
K
Y
A
I
K
Q
G
Q
K
F
A
T
P
I
K
P
I
---
P
D
G
Q
Y
G
F
A
V
K
K
G
S
N
P
E
L
I
E
M
F
N
N
G
L
A
N
L
R
A
N
G
E
Y
D
K
I
I
D
K
Y
L
E
S
D
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
63.91
58%
-10
- C1 -
-
4KR5
3
?
A:
[3-229]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
T
-
P
K
K
D
V
Y
---
T
I
A
S
D
N
S
F
A
P
F
E
F
Q
N
D
D
K
Q
F
T
G
I
D
V
D
L
L
N
A
I
A
K
N
Q
G
F
K
L
K
W
N
F
-
I
G
F
Q
A
A
V
D
S
V
Q
S
G
H
A
D
G
M
M
S
G
M
S
I
T
D
A
R
K
Q
V
F
D
Y
G
S
P
Y
Y
S
S
N
L
T
I
A
T
S
S
T
D
-
D
S
-
I
-
K
S
W
K
D
L
K
G
K
T
L
G
A
K
N
G
T
A
S
F
D
Y
L
N
A
H
A
K
E
Y
G
Y
T
V
K
T
F
T
D
A
T
T
M
Y
S
S
L
N
N
G
S
I
N
A
L
M
D
D
E
P
V
I
K
Y
A
I
K
Q
G
Q
K
F
A
T
P
I
K
P
I
---
P
D
G
Q
Y
G
F
A
V
K
K
G
S
N
P
E
L
I
E
M
F
N
N
G
L
A
N
L
R
A
N
G
E
Y
D
K
I
I
D
K
Y
L
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
42
HHSearch
58.25
45%
-12
- C1 -
-
4ZEF
1
?
A:
[24-250]
--------------------------
T
P
K
K
E
K
Y
V
I
-
A
S
D
S
T
F
A
P
F
E
F
Q
N
A
Q
G
D
Y
V
G
I
D
V
D
L
V
K
R
A
A
E
L
Q
G
F
T
V
E
F
K
-
F
I
G
F
S
S
A
V
Q
A
V
E
S
G
Q
A
D
G
M
V
A
G
M
T
I
T
D
D
R
K
K
A
F
D
F
S
V
P
Y
F
D
S
G
I
Q
I
A
V
K
K
G
N
D
K
I
K
S
Y
D
D
L
K
G
K
K
V
G
V
K
I
G
T
E
S
A
D
F
L
E
K
N
K
K
K
Y
-
D
Y
S
I
K
Y
L
D
T
T
D
A
L
Y
S
A
L
E
I
G
E
V
D
A
M
M
D
D
Y
P
V
I
G
Y
G
V
A
Q
N
Q
P
L
A
T
P
I
-
P
R
E
K
---
G
G
S
Y
G
F
A
V
K
K
G
Q
N
P
-
E
L
L
E
M
F
N
E
G
L
K
E
M
K
R
T
G
E
Y
D
K
I
I
G
T
Y
V
K
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
38
HHSearch
57.15
49%
-13
- C1 -
-
4ZEF
1
?
A:
[15-250]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
Y
F
Q
G
M
K
K
I
T
-
P
K
K
E
K
Y
---
V
I
A
S
D
S
T
F
A
P
F
E
F
Q
N
A
Q
G
D
Y
V
G
I
D
V
D
L
V
K
R
A
A
E
L
Q
G
F
T
V
E
F
K
F
-
I
G
F
S
S
A
V
Q
A
V
E
S
G
Q
A
D
G
M
V
A
G
M
T
I
T
D
D
R
K
K
A
F
D
F
S
V
P
Y
F
D
S
G
-
I
Q
I
A
V
K
K
G
N
D
K
-
I
-
K
S
Y
D
D
L
K
G
K
K
V
G
V
K
I
G
T
E
S
A
D
F
L
E
K
N
K
K
K
Y
D
Y
S
I
K
Y
L
D
T
T
D
A
L
Y
S
A
L
E
I
G
E
V
D
A
M
M
D
D
Y
P
V
I
G
Y
G
V
A
Q
N
Q
P
L
A
T
P
I
P
R
E
---
K
G
G
S
Y
G
F
A
V
K
K
G
Q
N
P
E
L
L
E
M
F
N
E
G
L
K
E
M
K
R
T
G
E
Y
D
K
I
I
G
T
Y
V
K
D
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
60
Fugue
56.26
20%
32
- C1 -
-
4Q0C
-
BVGS_BORPE
A:
[33-545]
S
Q
E
L
T
LV
G
K
A
A
V
P
D
V
E
V
A
L
D
G
D
D
W
R
W
L
A
R
K
R
V
L
T
L
G
V
Y
A
P
D
I
P
P
F
D
V
T
Y
G
E
-
R
Y
E
G
L
T
A
D
Y
M
A
I
I
A
H
N
L
G
M
Q
A
K
V
L
R
Y
P
T
R
E
Q
A
L
S
A
L
E
S
G
Q
I
D
-
L
I
G
T
V
N
G
T
D
G
R
Q
Q
S
L
R
L
S
V
P
Y
A
A
D
H
P
V
I
V
M
P
I
G
-
A
R
H
V
P
A
S
N
L
A
G
Q
R
L
A
V
D
I
N
Y
L
P
---
K
E
T
L
A
R
A
Y
P
Q
A
T
L
H
Y
F
P
S
S
E
Q
A
L
A
A
V
A
Y
G
Q
A
D
V
F
I
G
D
A
L
T
T
S
H
L
V
S
Q
S
Y
F
N
D
V
R
V
-
V
A
P
A
H
I
A
T
G
G
E
S
F
G
V
R
A
D
N
--
T
R
L
L
R
V
V
N
A
V
L
E
A
I
P
P
S
E
H
R
S
L
I
Y
R
-
W
G
L
G
S
S
I
S
L
D
F
A
H
P
A
Y
S
A
R
E
Q
-
Q
W
M
A
D
H
P
V
V
K
V
A
V
L
N
L
F
A
P
F
T
L
F
R
T
D
E
Q
F
G
G
I
S
A
A
V
L
Q
L
L
Q
L
R
T
G
L
D
F
E
I
I
G
V
D
T
V
E
E
L
I
A
K
L
R
S
G
E
A
D
-
M
A
G
A
L
F
V
N
S
A
R
E
S
F
L
S
F
S
R
P
Y
V
R
N
G
-
M
V
I
V
T
R
Q
D
-
P
D
-
A
P
V
D
A
D
H
L
D
G
R
T
V
A
L
V
R
N
S
A
A
I
P
L
L
Q
R
R
Y
P
Q
A
--
K
V
V
T
A
D
N
P
S
E
A
M
L
M
V
A
N
G
Q
A
D
A
V
V
Q
T
Q
I
S
A
S
Y
Y
V
N
R
Y
F
A
G
K
L
R
I
A
S
A
LDL
P
P
A
E
I
A
L
A
T
T
R
G
-
Q
T
E
L
M
S
I
L
N
K
A
L
Y
S
I
S
-
N
D
E
L
A
S
I
I
S
R
W
R
G
S
D
G
--------
D
P
R
T
W
Y
A
Y
R
N
E
I
Y
L
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
52
HHSearch
55.11
49%
-77
- C1 -
-
4LA9
-
?
B:
[30-252]
-----------------------------
E
T
T
V
K
I
-
A
S
D
S
S
Y
A
P
F
E
F
Q
N
G
Q
K
K
W
V
G
I
D
V
D
I
M
Q
E
V
A
K
I
N
D
W
K
L
E
M
S
-
Y
P
G
F
D
A
A
L
Q
N
L
K
A
G
Q
V
D
G
I
I
A
G
M
T
I
T
D
E
R
K
E
T
F
D
F
S
N
P
Y
Y
T
S
A
L
T
I
A
T
T
K
D
-
S
K
L
S
D
Y
S
D
L
K
G
K
A
V
G
A
K
N
G
T
A
A
Q
T
W
L
Q
E
N
Q
K
K
Y
-
G
Y
T
I
K
T
Y
-
D
G
V
H
M
F
A
A
L
S
S
G
N
I
A
G
A
M
D
E
V
P
V
I
S
Y
A
M
K
Q
G
Q
D
L
A
M
N
F
P
S
I
S
L
---
P
G
G
Y
G
F
A
V
M
K
G
K
N
S
-
T
L
V
D
G
F
N
K
A
L
A
E
M
K
S
N
G
D
Y
D
K
I
L
K
K
Y
G
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
53.55
51%
-1
- C1 -
-
4G4P
2
?
A:
[24-244]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
Y
---
T
I
G
T
D
L
T
F
A
P
F
E
F
Q
D
S
K
G
K
Y
I
G
I
D
V
D
L
L
D
A
I
A
K
D
Q
D
F
E
V
D
L
K
P
-
L
G
F
D
S
A
V
Q
A
I
Q
S
K
Q
I
D
G
M
I
A
G
M
S
I
T
D
E
R
K
K
S
F
D
F
S
D
P
Y
F
D
S
G
-
L
Q
L
A
V
K
K
G
-
N
D
K
I
-
K
S
Y
D
D
L
K
G
K
T
V
A
A
K
V
G
T
E
S
A
N
F
L
E
K
N
K
E
K
Y
D
Y
T
I
K
N
F
D
D
A
T
G
L
Y
K
A
L
E
N
G
E
A
D
A
I
V
D
D
Y
P
V
L
G
Y
A
V
K
N
G
Q
K
L
Q
L
V
G
D
K
E
---
T
G
S
S
Y
G
F
A
V
K
K
G
Q
N
P
E
L
I
K
K
F
N
A
G
L
K
N
L
K
D
N
G
T
Y
D
K
I
L
N
N
Y
L
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
53
HHSearch
52.86
49%
-79
- C1 -
-
4LA9
7
?
A:
[29-252]
----------------------------
A
E
T
T
V
K
I
-
A
S
D
S
S
Y
A
P
F
E
F
Q
N
G
Q
K
K
W
V
G
I
D
V
D
I
M
Q
E
V
A
K
I
N
D
W
K
L
E
M
S
-
Y
P
G
F
D
A
A
L
Q
N
L
K
A
G
Q
V
D
G
I
I
A
G
M
T
I
T
D
E
R
K
E
T
F
D
F
S
N
P
Y
Y
T
S
A
L
T
I
A
T
T
K
D
-
S
K
L
S
D
Y
S
D
L
K
G
K
A
V
G
A
K
N
G
T
A
A
Q
T
W
L
Q
E
N
Q
K
K
Y
-
G
Y
T
I
K
T
Y
S
D
G
V
H
M
F
A
A
L
S
S
G
N
I
A
G
A
M
D
E
V
P
V
I
S
Y
A
M
K
Q
G
Q
D
L
A
M
N
F
P
S
I
S
L
---
P
G
G
Y
G
F
A
V
M
K
G
K
N
S
-
T
L
V
D
G
F
N
K
A
L
A
E
M
K
S
N
G
D
Y
D
K
I
L
K
K
Y
G
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
52.81
50%
53
- C1 -
-
4ZEF
1
?
A:
[17-248]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
Q
G
M
K
K
I
T
P
K
K
E
K
Y
---
V
I
A
S
D
S
T
F
A
P
F
E
F
Q
N
A
Q
G
D
Y
V
G
I
D
V
D
L
V
K
R
A
A
E
L
Q
G
F
T
V
E
F
K
F
-
I
G
F
S
S
A
V
Q
A
V
E
S
G
Q
A
D
G
M
V
A
G
M
T
I
T
D
D
R
K
K
A
F
D
F
S
V
P
Y
F
D
S
G
-
I
Q
I
A
V
K
K
G
-
N
D
K
I
-
K
S
Y
D
D
L
K
G
K
K
V
G
V
K
I
G
T
E
S
A
D
F
L
E
K
N
K
K
K
Y
D
Y
S
I
K
Y
L
D
T
T
D
A
L
Y
S
A
L
E
I
G
E
V
D
A
M
M
D
D
Y
P
V
I
G
Y
G
V
A
Q
N
Q
P
L
A
T
P
I
P
R
E
---
K
G
G
S
Y
G
F
A
V
K
K
G
Q
N
P
E
L
L
E
M
F
N
E
G
L
K
E
M
K
R
T
G
E
Y
D
K
I
I
G
T
Y
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
45
HHSearch
52.64
41%
-1
- C1 -
-
4G4P
2
?
A:
[17-243]
------------------------
F
Q
G
M
E
G
K
K
Y
T
I
-
G
T
D
L
T
F
A
P
F
E
F
Q
D
S
K
G
K
Y
I
G
I
D
V
D
L
L
D
A
I
A
K
D
Q
D
F
E
V
D
L
K
-
P
L
G
F
D
S
A
V
Q
A
I
Q
S
K
Q
I
D
G
M
I
A
G
M
S
I
T
D
E
R
K
K
S
F
D
F
S
D
P
Y
F
D
S
G
L
Q
L
A
V
K
K
G
N
D
K
I
K
S
Y
D
D
L
K
G
K
T
V
A
A
K
V
G
T
E
S
A
N
F
L
E
K
N
K
E
K
Y
-
D
Y
T
I
K
N
F
D
D
A
T
G
L
Y
K
A
L
E
N
G
E
A
D
A
I
V
D
D
Y
P
V
L
G
Y
A
V
K
N
G
Q
K
L
Q
L
V
G
-
D
K
E
T
---
G
S
S
Y
G
F
A
V
K
K
G
Q
N
P
-
E
L
I
K
K
F
N
A
G
L
K
N
L
K
D
N
G
T
Y
D
K
I
L
N
N
Y
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
50.47
37%
-175
- C2 -
-
4YMW
2
?
D:
[16-215]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
S
G
L
I
M
T
L
K
L
T
F
L
A
V
T
I
G
V
L
M
G
L
F
I
A
L
M
K
M
S
S
I
K
P
I
K
L
V
A
S
S
Y
I
E
V
I
R
G
T
P
L
L
V
Q
L
L
L
I
Y
N
G
L
M
Q
F
-----
G
M
N
I
P
--
A
F
T
A
G
V
S
A
L
A
I
N
S
S
A
Y
V
A
E
I
I
R
A
G
I
Q
A
V
D
P
G
Q
N
E
A
A
R
S
L
G
M
T
H
A
M
A
M
R
Y
V
I
I
P
Q
A
I
K
N
I
L
P
A
L
G
N
E
F
I
V
M
L
K
E
S
A
I
V
S
V
I
G
F
A
D
L
T
R
Q
A
D
I
I
Q
S
V
T
Y
R
Y
F
E
P
Y
I
I
I
A
A
I
Y
F
V
M
T
L
T
F
S
K
L
L
S
L
F
E
R
R
L
R
27
PsiBlast_CBE
50.32
37%
-180
- C2 -
-
4YMT
2
?
B:
[16-215]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
S
G
L
I
M
T
L
K
L
T
F
L
A
V
T
I
G
V
L
M
G
L
F
I
A
L
M
K
M
S
S
I
K
P
I
K
L
V
A
S
S
Y
I
E
V
I
R
G
T
P
L
L
V
Q
L
L
L
I
Y
N
G
L
M
Q
F
-----
G
M
N
I
P
--
A
F
T
A
G
V
S
A
L
A
I
N
S
S
A
Y
V
A
E
I
I
R
A
G
I
Q
A
V
D
P
G
Q
N
E
A
A
R
S
L
G
M
T
H
A
M
A
M
R
Y
V
I
I
P
Q
A
I
K
N
I
L
P
A
L
G
N
E
F
I
V
M
L
K
E
S
A
I
V
S
V
I
G
F
A
D
L
T
R
Q
A
D
I
I
Q
S
V
T
Y
R
Y
F
E
P
Y
I
I
I
A
A
I
Y
F
V
M
T
L
T
F
S
K
L
L
S
L
F
E
R
R
L
R
26
PsiBlast_CBE
49.83
37%
-180
- C2 -
-
4YMU
2
?
C:
[16-214]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
S
G
L
I
M
T
L
K
L
T
F
L
A
V
T
I
G
V
L
M
G
L
F
I
A
L
M
K
M
S
S
I
K
P
I
K
L
V
A
S
S
Y
I
E
V
I
R
G
T
P
L
L
V
Q
L
L
L
I
Y
N
G
L
M
Q
F
-----
G
M
N
I
P
--
A
F
T
A
G
V
S
A
L
A
I
N
S
S
A
Y
V
A
E
I
I
R
A
G
I
Q
A
V
D
P
G
Q
N
E
A
A
R
S
L
G
M
T
H
A
M
A
M
R
Y
V
I
I
P
Q
A
I
K
N
I
L
P
A
L
G
N
E
F
I
V
M
L
K
E
S
A
I
V
S
V
I
G
F
A
D
L
T
R
Q
A
D
I
I
Q
S
V
T
Y
R
Y
F
E
P
Y
I
I
I
A
A
I
Y
F
V
M
T
L
T
F
S
K
L
L
S
L
F
E
R
R
L
-
10
PsiBlast_PDB
49.67
37%
-177
- C2 -
-
4YMU
2
?
D:
[16-215]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
S
G
L
I
M
T
L
K
L
T
F
L
A
V
T
I
G
V
L
M
G
L
F
I
A
L
M
K
M
S
S
I
K
P
I
K
L
V
A
S
S
Y
I
E
V
I
R
G
T
P
L
L
V
Q
L
L
L
I
Y
N
G
L
M
Q
F
-----
G
M
N
I
P
--
A
F
T
A
G
V
S
A
L
A
I
N
S
S
A
Y
V
A
E
I
I
R
A
G
I
Q
A
V
D
P
G
Q
N
E
A
A
R
S
L
G
M
T
H
A
M
A
M
R
Y
V
I
I
P
Q
A
I
K
N
I
L
P
A
L
G
N
E
F
I
V
M
L
K
E
S
A
I
V
S
V
I
G
F
A
D
L
T
R
Q
A
D
I
I
Q
S
V
T
Y
R
Y
F
E
P
Y
I
I
I
A
A
I
Y
F
V
M
T
L
T
F
S
K
L
L
S
L
F
E
R
R
L
R
25
PsiBlast_CBE
49.59
37%
-180
- C2 -
-
4YMW
2
?
C:
[16-214]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
S
G
L
I
M
T
L
K
L
T
F
L
A
V
T
I
G
V
L
M
G
L
F
I
A
L
M
K
M
S
S
I
K
P
I
K
L
V
A
S
S
Y
I
E
V
I
R
G
T
P
L
L
V
Q
L
L
L
I
Y
N
G
L
M
Q
F
-----
G
M
N
I
P
--
A
F
T
A
G
V
S
A
L
A
I
N
S
S
A
Y
V
A
E
I
I
R
A
G
I
Q
A
V
D
P
G
Q
N
E
A
A
R
S
L
G
M
T
H
A
M
A
M
R
Y
V
I
I
P
Q
A
I
K
N
I
L
P
A
L
G
N
E
F
I
V
M
L
K
E
S
A
I
V
S
V
I
G
F
A
D
L
T
R
Q
A
D
I
I
Q
S
V
T
Y
R
Y
F
E
P
Y
I
I
I
A
A
I
Y
F
V
M
T
L
T
F
S
K
L
L
S
L
F
E
R
R
L
-
8
PsiBlast_PDB
48.89
37%
-176
- C2 -
-
4YMS
-
?
D:
[16-215]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
S
G
L
I
M
T
L
K
L
T
F
L
A
V
T
I
G
V
L
M
G
L
F
I
A
L
M
K
M
S
S
I
K
P
I
K
L
V
A
S
S
Y
I
E
V
I
R
G
T
P
L
L
V
Q
L
L
L
I
Y
N
G
L
M
Q
F
-----
G
M
N
I
P
--
A
F
T
A
G
V
S
A
L
A
I
N
S
S
A
Y
V
A
E
I
I
R
A
G
I
Q
A
V
D
P
G
Q
N
E
A
A
R
S
L
G
M
T
H
A
M
A
M
R
Y
V
I
I
P
Q
A
I
K
N
I
L
P
A
L
G
N
E
F
I
V
M
L
K
E
S
A
I
V
S
V
I
G
F
A
D
L
T
R
Q
A
D
I
I
Q
S
V
T
Y
R
Y
F
E
P
Y
I
I
I
A
A
I
Y
F
V
M
T
L
T
F
S
K
L
L
S
L
F
E
R
R
L
R
11
PsiBlast_PDB
48.76
37%
-176
- C2 -
-
4YMV
-
?
D:
[16-215]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
S
G
L
I
M
T
L
K
L
T
F
L
A
V
T
I
G
V
L
M
G
L
F
I
A
L
M
K
M
S
S
I
K
P
I
K
L
V
A
S
S
Y
I
E
V
I
R
G
T
P
L
L
V
Q
L
L
L
I
Y
N
G
L
M
Q
F
-----
G
M
N
I
P
--
A
F
T
A
G
V
S
A
L
A
I
N
S
S
A
Y
V
A
E
I
I
R
A
G
I
Q
A
V
D
P
G
Q
N
E
A
A
R
S
L
G
M
T
H
A
M
A
M
R
Y
V
I
I
P
Q
A
I
K
N
I
L
P
A
L
G
N
E
F
I
V
M
L
K
E
S
A
I
V
S
V
I
G
F
A
D
L
T
R
Q
A
D
I
I
Q
S
V
T
Y
R
Y
F
E
P
Y
I
I
I
A
A
I
Y
F
V
M
T
L
T
F
S
K
L
L
S
L
F
E
R
R
L
R
9
PsiBlast_PDB
48.58
37%
-179
- C2 -
-
4YMT
2
?
C:
[16-215]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
S
G
L
I
M
T
L
K
L
T
F
L
A
V
T
I
G
V
L
M
G
L
F
I
A
L
M
K
M
S
S
I
K
P
I
K
L
V
A
S
S
Y
I
E
V
I
R
G
T
P
L
L
V
Q
L
L
L
I
Y
N
G
L
M
Q
F
-----
G
M
N
I
P
--
A
F
T
A
G
V
S
A
L
A
I
N
S
S
A
Y
V
A
E
I
I
R
A
G
I
Q
A
V
D
P
G
Q
N
E
A
A
R
S
L
G
M
T
H
A
M
A
M
R
Y
V
I
I
P
Q
A
I
K
N
I
L
P
A
L
G
N
E
F
I
V
M
L
K
E
S
A
I
V
S
V
I
G
F
A
D
L
T
R
Q
A
D
I
I
Q
S
V
T
Y
R
Y
F
E
P
Y
I
I
I
A
A
I
Y
F
V
M
T
L
T
F
S
K
L
L
S
L
F
E
R
R
L
R