@TOME V2.3
(Mar 2018)
Ref.
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : spr1126: (2018-01-05 )
MYLKEIEIQGFKSFADKTKVVFDQGVTAVVGPNGSGKSNITESLRWALGESSVKSLRGGKMPDVIFAGTESRKPLNYASVVVTLDNHDGFIKDAGQEIRVERHIYRSGDSEYKIDGKKVRLRDIHDLFLDTGLGRDSFSIISQGKVEEIFNSKPEERRAIFEEAAGVLKYKTRRKETESKLQQTQDNLDRLEDIIYELDNQIKPLEKQAENARKFLDLEGQRKVIYLDVLVAQIKENKAELESTEEELAQVQELLMSYYQKREKLEEENQTLKKQRQDLQAEMAKDQGSLMDLTSLISDLERKLALSKLESEQVALNQQEAQARLAALEDKRNSLSKEKYDKESSLALLEGNLVQNNQKLNRLEAELLAFSDDPDQMIELLRERFVALLQEEADVSNQLTRIENELENSRQLSQKQADQLEKLKEQLATAKEKASQQKDELETAKVQVQKLLADYQAIAKEQEEQKTSYQAQQSQLFDRLDSLKNKQARAQSLENILRNHSNFYAGVKSVLQEKDRLGGIIGAVSEHLTFDVYYQTALEIALGASSQHIIVEDEESATKAIDFLKRNRVGRATFLPLTTIKARTISSQNQDAIAVSPGFLGMADELVTFDTRLEAIFKNLLATTAIFDTVEHAREAARQVRYQVRMVTLDGTELRTGGSYAGGANRQNNSIFIKPELEQLQKEIAADEASLGSEEAALKTLQDQMAALTERLEAIKSQGEQARIQEQGLSLAYQQTSQQVEELETLWKLQEEEIDRLSEGDWQADKEKCQESLATIASEKQNLEAEIEEIKSNKNAIQERYQNLQEEVAQARLLKTELQGQKRYEVADIERLGKELDNLNIEQEEIQRMLQEKVDNLEKVDTELLSQQAEESKTQKTNLQQGLIRKQFELDDIEGQLDDIASHLDQARQQNEEWIRKQTRAEAKKEKVSERLRHLQNQLTDQYQISYTEALEKAHELENLNLAEQEVQDLEKAIRSLGPVNLEAIDQYEEVHNRLDFLNSQRDDILSAKNLLLETITEMNDEVKERFKSTFEAIRESFKVTFKQMFGGGQADLILTEGDLLTAGVEISVQPPGKKIQSLNLMSGGEKALSALALLFSIIRVKTIPFVILDEVEAALDEANVKRFGDYLNRFDKDSQFIVVTHRKGTMAAADSIYGVTMQESGVSKIVSVKLKDLESIEG
Atome Classification :
(21 SA)
.........10......-..20-........30........40........50........60........70........80.......-.90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530........540.......550.......560.......-570.......580.......590........600.......610.......620.......630.......640.......650.......660......---.670-....-...680.......690.......700.......710.......720.......730.......740.......750.......760.......770.......780.......790.......800.......810.......820.......830-------.......840.......850----.......860.......870.......880--........890.......900.......910----.........920.......930.......940.......950.......960.......970.......980.......990.......1000......1010......1020......1030......1040......1050....-.-.1060......1070......1080......1090......1100......1110......1120......1130......1140......1150......1160......1170......
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MY
L
K
E
I
E
I
Q
G
F
K
S
F
ADK-
T
K
V
V
-FDQG
V
T
A
V
VGPNGSG
K
S
N
I
T
E
S
L
R
W
A
L
G
E
S
S
V
K
S
LRGGKMP
D
V
I
F
AGTESRKPL
N
Y
A
S
V
V
V
T
LDNHD-
G
F
I
K
DAG
Q
E
I
R
V
E
R
H
I
YRSGDS
E
Y
K
IDG
K
K
V
R
L
R
D
I
H
D
L
F
L
DTGLGRD
S
F
S
I
ISQG
K
V
E
E
I
F
NSK
P
E
E
R
R
A
I
F
E
E
A
A
G
V
L
K
Y
K
T
R
R
K
E
T
E
S
K
L
Q
Q
T
Q
D
N
L
D
R
L
E
D
I
I
Y
E
LDNQIK
P
L
E
K
Q
A
E
N
A
R
K
F
LDLEGQ
R
K
V
I
Y
L
D
V
L
V
A
Q
I
K
E
N
K
A
E
L
E
S
T
E
E
E
L
A
Q
V
Q
E
L
L
M
S
Y
Y
Q
K
R
E
K
L
E
E
E
N
Q
T
L
K
K
Q
R
Q
D
L
Q
A
E
M
A
KDQG
S
L
M
D
L
T
S
L
I
S
D
L
E
R
K
L
A
L
S
K
LE
S
E
Q
V
A
L
N
Q
Q
E
A
Q
A
R
L
A
A
L
E
D
K
R
N
SL
S
K
E
KYDKES
S
L
A
L
LEGNLVQN
N
Q
K
L
N
R
L
E
A
E
L
LAFSD
D
P
D
Q
M
I
E
L
L
R
E
R
F
V
A
L
L
Q
E
E
A
D
V
S
N
Q
L
T
R
I
E
N
E
L
E
N
S
R
Q
L
S
Q
K
Q
A
D
Q
L
E
K
L
K
E
Q
L
A
T
A
K
E
K
A
S
Q
Q
K
D
E
L
E
T
A
K
V
Q
V
Q
K
L
L
A
D
Y
Q
A
I
A
K
E
Q
E
E
Q
K
T
S
Y
Q
A
Q
Q
S
Q
L
F
D
R
L
D
S
L
K
N
K
Q
A
R
A
Q
S
L
E
N
I
L
R
NHS
N
F
Y
A
G
V
K
S
V
L
Q
E
K
D
RL
G
G
I
I
G
A
V
S
EH
L
T
F
-
D
V
Y
Y
Q
T
A
L
E
IALGASS
Q
H
I
I
V
EDEE
S
A
T
K
A
I
D
F
L
K
RNRV-GR
A
T
F
L
P
L
T
T
I
K
A
R
TISSQNQ
D
-
A
I
A
VSPGFLG
M
A
D
E
L
V
T
F
D
T
R
L
E
A
I
F
K
N
L
L
A
T
T
A
I
F
D
T
V
E
H
A
R
E
A
A
R
Q
V
R
Y
Q
V
R
M
V
T
LDGTELRTGGSYAGGANRQN---
N
S
I
F
-IKP
E
-
L
E
Q
L
Q
K
E
IAADEASLG
S
E
E
A
A
L
K
T
L
Q
D
Q
M
A
A
L
T
E
R
L
E
A
I
K
SQ
G
E
Q
A
R
I
Q
E
QG
L
S
L
A
Y
Q
Q
T
S
Q
Q
V
E
E
L
E
T
L
W
K
L
Q
E
E
E
I
D
R
LSEGDW
Q
A
D
K
E
K
C
Q
E
S
L
A
T
I
A
S
E
K
Q
N
L
E
A
E
I
E
E
I
KS
N
K
N
A
I
Q
E
R
Y
Q
N
L
Q
E
E
V
A
Q
A
R
L
L
K
T
E
LQGQKRY
E
V
A
D
I
E
R
L
-------
G
K
E
L
DNLNI
E
Q
E
E
I
Q
R
M
L
Q
E
----
K
V
D
N
L
E
K
V
D
T
E
L
L
S
Q
Q
A
E
E
SKTQK
T
N
L
Q
Q
---
G
L
I
R
K
QFEL
D
D
IE
G
Q
L
D
D
I
A
S
H
L
D
Q
A
R
Q
Q
------
N
E
E
W
I
R
K
Q
T
R
A
E
A
K
K
E
K
V
S
E
R
L
R
H
L
Q
N
QL
T
D
Q
Y
Q
I
S
Y
T
E
A
L
E
K
A
H
E
LENLN
L
A
E
Q
E
V
Q
D
L
E
K
A
I
R
SLGPV
N
L
E
A
I
D
Q
Y
E
E
V
H
N
R
L
D
F
L
NSQ
R
D
D
I
L
S
A
K
N
L
L
L
E
T
I
T
EM
N
D
E
V
K
E
R
F
K
S
T
F
E
A
I
R
E
S
F
K
V
T
F
K
Q
M
FGGGQ
A
D
L
I
L
TE-G-
D
L
L
T
AG
V
E
I
S
VQPPGK
K
I
Q
S
L
NLMSG
G
E
K
A
L
S
A
L
A
L
L
F
S
I
I
RVKTI
P
F
V
I
L
D
E
V
E
A
A
L
D
E
A
N
V
K
R
F
G
D
Y
L
N
R
FDKDS
Q
F
I
V
V
THRKGTMAAAD
S
I
Y
G
V
T
MQESGVS
K
I
V
S
V
K
L
K
D
L
E
SIEG
1
PsiBlast_PDB
78.33
63%
-90
* C2 *
-
5H66
-
?
A:
[1-199]
M
F
L
K
R
L
D
V
I
G
F
K
S
F
A
E
R
-
I
S
V
D
-
F
V
K
G
V
T
A
V
V
G
P
N
G
S
G
K
S
N
I
T
D
A
I
R
W
V
L
G
------------
E
D
I
I
F
A
G
S
D
S
R
K
R
L
N
L
A
E
V
T
L
T
L
D
N
D
D
-
H
F
L
P
I
D
F
H
E
V
S
V
T
R
R
V
Y
R
S
G
E
S
E
F
L
I
N
N
Q
P
C
R
L
K
D
I
I
D
L
F
M
D
S
G
L
G
K
E
A
F
S
I
I
S
Q
G
K
V
E
E
I
L
S
S
K
A
E
D
R
R
S
I
F
E
E
A
A
G
V
L
K
Y
K
T
R
K
K
K
A
E
N
K
L
F
E
T
Q
D
N
L
N
R
V
E
D
I
L
H
E
L
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
77.35
63%
-76
- C2 -
-
5H67
1
SMC_BACSU
A:
[1-199]
M
F
L
K
R
L
D
V
I
G
F
K
S
F
A
E
R
-
I
S
V
D
-
F
V
K
G
V
T
A
V
V
G
P
N
G
S
G
K
S
N
I
T
D
A
I
R
W
V
L
G
E
Q
S
A
R
S
L
R
G
G
K
M
E
D
I
I
F
A
G
S
D
S
R
K
R
L
N
L
A
E
V
T
L
T
L
D
N
D
D
-
H
F
L
P
I
D
F
H
E
V
S
V
T
R
R
V
Y
R
S
G
E
S
E
F
L
I
N
N
Q
P
C
R
L
K
D
I
I
D
L
F
M
D
S
G
L
G
K
E
A
F
S
I
I
S
Q
G
K
V
E
E
I
L
S
S
K
A
E
D
R
R
S
I
F
E
E
A
A
G
V
L
K
Y
K
T
R
K
K
K
A
E
N
K
L
F
E
T
Q
D
N
L
N
R
V
E
D
I
L
H
E
L
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
78
HHSearch
75.93
63%
-90
- C2 -
-
5H66
-
?
A:
[1-184]
M
F
L
K
R
L
D
V
I
G
F
K
S
F
A
E
R
-
I
S
V
D
-
F
V
K
G
V
T
A
V
V
G
P
N
G
S
G
K
S
N
I
T
D
A
I
R
W
V
L
G
------------
E
D
I
I
F
A
G
S
D
S
R
K
R
L
N
L
A
E
V
T
L
T
L
D
N
D
D
-
H
F
L
P
I
D
F
H
E
V
S
V
T
R
R
V
Y
R
S
G
E
S
E
F
L
I
N
N
Q
P
C
R
L
K
D
I
I
D
L
F
M
D
S
G
L
G
K
E
A
F
S
I
I
S
Q
G
K
V
E
E
I
L
S
S
K
A
E
D
R
R
S
I
F
E
E
A
A
G
V
L
K
Y
K
T
R
K
K
K
A
E
N
K
L
F
E
T
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
79
HHSearch
75.55
63%
-76
- C2 -
-
5H67
1
SMC_BACSU
A:
[1-184]
M
F
L
K
R
L
D
V
I
G
F
K
S
F
A
E
R
-
I
S
V
D
-
F
V
K
G
V
T
A
V
V
G
P
N
G
S
G
K
S
N
I
T
D
A
I
R
W
V
L
G
E
Q
S
A
R
S
L
R
G
G
K
M
E
D
I
I
F
A
G
S
D
S
R
K
R
L
N
L
A
E
V
T
L
T
L
D
N
D
D
-
H
F
L
P
I
D
F
H
E
V
S
V
T
R
R
V
Y
R
S
G
E
S
E
F
L
I
N
N
Q
P
C
R
L
K
D
I
I
D
L
F
M
D
S
G
L
G
K
E
A
F
S
I
I
S
Q
G
K
V
E
E
I
L
S
S
K
A
E
D
R
R
S
I
F
E
E
A
A
G
V
L
K
Y
K
T
R
K
K
K
A
E
N
K
L
F
E
T
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
PsiBlast_CBE
70.48
59%
-19
- C2 -
-
5H67
1
?
B:
[2-181]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
Y
K
F
L
S
E
Q
K
E
D
L
T
E
A
K
N
T
L
F
Q
V
I
E
E
M
D
E
E
M
T
K
R
F
N
D
T
F
V
Q
I
R
S
H
F
D
Q
V
F
R
S
L
F
G
G
G
R
A
E
L
R
L
T
D
P
N
-
D
L
L
H
S
G
V
E
I
I
A
Q
P
P
G
K
K
L
Q
N
L
N
L
L
S
G
G
E
R
A
L
T
A
I
A
L
L
F
S
I
L
K
V
R
P
V
P
F
C
V
L
D
Q
V
E
A
A
L
D
E
A
N
V
F
R
F
A
Q
Y
L
K
K
Y
S
S
D
T
Q
F
I
V
I
T
H
R
K
G
T
M
E
E
A
D
V
L
Y
G
V
T
M
Q
E
S
G
V
S
K
V
I
S
V
K
L
E
-------
4
PsiBlast_PDB
67.72
41%
-179
- C3 -
-
5H69
-
?
A:
[7-193]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
K
T
E
L
E
Q
H
E
A
L
L
H
Q
A
R
Q
Y
R
Q
Q
T
K
A
R
Q
Q
W
L
E
E
M
Q
H
D
Y
S
G
F
V
Q
G
V
K
E
V
L
K
A
R
D
L
L
P
G
I
H
G
A
I
V
E
L
I
R
V
-
P
D
R
Y
E
T
A
I
E
T
A
L
G
G
A
M
Q
H
I
V
V
D
S
E
Q
A
A
R
Q
A
I
H
Y
L
K
T
N
G
Y
-
G
R
A
T
F
L
P
L
D
V
I
K
A
R
A
L
S
E
R
E
R
A
-
A
I
D
R
H
P
A
F
V
G
I
A
S
E
L
V
E
Y
D
R
A
Y
R
A
A
I
A
H
L
L
G
H
V
I
V
T
A
D
L
K
G
A
N
E
L
A
K
L
L
H
Y
R
Y
R
L
V
T
L
D
G
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
67.41
29%
-144
- C3 -
-
1GXL
-
?
A:
[479-678]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
R
E
I
Q
F
E
K
E
M
I
E
R
D
M
R
E
Y
R
G
F
S
R
A
V
R
A
V
F
E
E
K
E
R
F
P
G
L
V
D
V
V
S
N
L
I
E
V
-
D
E
K
Y
S
L
A
V
S
V
L
L
G
G
T
A
Q
N
I
V
V
R
N
V
D
T
A
K
A
I
V
E
F
L
K
Q
N
E
A
-
G
R
V
T
I
L
P
L
D
L
I
D
G
---
S
F
N
R
I
S
-
G
L
E
N
E
R
G
F
V
G
Y
A
V
D
L
V
K
F
P
S
D
L
E
V
L
G
G
F
L
F
G
N
S
V
V
V
E
T
L
D
D
A
I
R
M
K
K
K
Y
R
L
N
T
R
I
A
T
L
D
G
E
L
I
S
G
R
G
A
I
T
G
G
R
E
E
R
S
---
S
N
V
F
E
R
R
I
K
-
L
K
H
L
E
Q
E
M
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
97
Fugue
67.23
31%
-170
* C3 *
-
1GXJ
-
?
A:
[498-658]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
F
S
R
A
V
R
A
V
F
E
E
K
E
R
F
P
G
L
V
D
V
V
S
N
L
I
E
V
-
D
E
K
Y
S
L
A
V
S
V
L
L
G
G
T
A
Q
N
I
V
V
R
N
V
D
T
A
K
A
I
V
E
F
L
K
Q
N
E
A
-
G
R
V
T
I
L
P
L
D
L
I
D
G
S
---
F
N
R
I
S
-
G
L
E
N
E
R
G
F
V
G
Y
A
V
D
L
V
K
F
P
S
D
L
E
V
L
G
G
F
L
F
G
N
S
V
V
V
E
T
L
D
D
A
I
R
M
K
K
K
Y
R
L
N
T
R
I
A
T
L
D
G
E
L
I
S
G
R
G
A
I
T
G
G
R
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
66.57
29%
-170
- C3 -
-
1GXJ
-
?
A:
[498-658]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
F
S
R
A
V
R
A
V
F
E
E
K
E
R
F
P
G
L
V
D
V
V
S
N
L
I
E
V
-
D
E
K
Y
S
L
A
V
S
V
L
L
G
G
T
A
Q
N
I
V
V
R
N
V
D
T
A
K
A
I
V
E
F
L
K
Q
N
E
A
-
G
R
V
T
I
L
P
L
D
L
I
D
G
---
S
F
N
R
I
S
-
G
L
E
N
E
R
G
F
V
G
Y
A
V
D
L
V
K
F
P
S
D
L
E
V
L
G
G
F
L
F
G
N
S
V
V
V
E
T
L
D
D
A
I
R
M
K
K
K
Y
R
L
N
T
R
I
A
T
L
D
G
E
L
I
S
G
R
G
A
I
T
G
G
R
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
66.17
42%
-4
- C2 -
-
5XEI
-
?
A:
[297-509]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
L
E
V
L
R
K
E
I
E
D
M
E
A
E
I
K
A
L
E
P
V
N
M
K
A
I
E
D
F
E
V
V
E
R
R
Y
L
E
L
K
S
K
R
E
K
L
E
A
E
K
E
S
I
I
E
F
I
N
E
I
E
K
E
K
K
N
V
F
M
R
T
L
E
A
I
A
K
N
F
S
E
L
F
A
K
L
S
P
G
G
S
A
R
L
I
L
E
N
-
P
E
D
P
F
S
G
G
L
E
I
E
A
K
P
A
G
K
D
V
K
R
I
E
A
M
S
G
G
E
K
A
L
T
A
L
A
F
I
F
A
I
Q
R
F
K
P
A
P
F
Y
L
F
D
E
I
D
A
H
L
D
D
A
N
V
K
R
V
A
D
L
I
K
E
S
S
R
E
S
Q
F
I
V
I
T
L
R
D
V
M
M
A
N
A
D
K
I
I
G
V
S
M
R
D
-
G
V
S
R
V
V
S
L
S
L
--------
11
PsiBlast_PDB
64.94
29%
-169
- C3 -
-
1GXK
-
?
A:
[501-658]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
A
V
R
A
V
F
E
E
K
E
R
F
P
G
L
V
D
V
V
S
N
L
I
E
V
-
D
E
K
Y
S
L
A
V
S
V
L
L
G
G
T
A
Q
N
I
V
V
R
N
V
D
T
A
K
A
I
V
E
F
L
K
Q
N
E
A
-
G
R
V
T
I
L
P
L
D
L
I
D
G
---
S
F
N
R
I
S
-
G
L
E
N
E
R
G
F
V
G
Y
A
V
D
L
V
K
F
P
S
D
L
E
V
L
G
G
F
L
F
G
N
S
V
V
V
E
T
L
D
D
A
I
R
M
K
K
K
Y
R
L
N
T
R
I
A
T
L
D
G
E
L
I
S
G
R
G
A
I
T
G
G
R
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
81
HHSearch
64.93
37%
-157
- C3 -
-
5H69
-
?
A:
[60-251]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
G
I
H
G
A
I
V
E
L
I
R
V
-
P
D
R
Y
E
T
A
I
E
T
A
L
G
G
A
M
Q
H
I
V
V
D
S
E
Q
A
A
R
Q
A
I
H
Y
L
K
T
N
G
Y
-
G
R
A
T
F
L
P
L
D
V
I
K
A
R
A
L
S
E
R
E
R
A
-
A
I
D
R
H
P
A
F
V
G
I
A
S
E
L
V
E
Y
D
R
A
Y
R
A
A
I
A
H
L
L
G
H
V
I
V
T
A
D
L
K
G
A
N
E
L
A
K
L
L
H
Y
R
Y
R
L
V
T
L
D
G
D
V
V
S
P
G
G
A
M
T
G
G
G
A
A
K
K
T
--
A
S
L
L
S
R
N
R
E
-
L
E
M
L
S
A
K
L
Q
E
M
D
E
T
I
A
R
L
E
R
A
V
A
A
K
R
H
E
L
A
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
98
Fugue
62.44
18%
37
- C2 -
-
4UX3
1
SMC3_YEAST
A:
[3-527]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
I
K
R
V
I
I
K
G
F
K
T
Y
R
N
E
T
I
I
D
N
F
S
P
H
Q
N
V
I
I
G
S
N
G
S
--
G
K
S
N
F
F
A
A
I
R
F
V
L
S
D
D
Y
S
N
L
K
R
E
E
R
Q
G
L
I
H
Q
G
S
G
G
S
V
M
S
A
S
V
E
I
V
I
R
R
T
V
G
LKKD
D
Y
Q
L
N
D
R
N
V
T
K
G
D
I
V
R
M
L
E
T
A
GFS
M
N
N
P
Y
N
I
V
P
Q
G
K
I
V
A
L
T
N
A
K
D
K
E
R
L
Q
L
L
E
D
V
V
G
A
K
S
F
E
V
K
L
K
A
S
L
K
K
M
E
E
T
E
Q
K
K
I
Q
I
N
K
E
------
M
G
E
L
N
S
K
L
S
E
M
E
Q
E
R
K
E
L
E
K
Y
N
E
L
E
R
N
R
K
I
Y
Q
F
T
L
Y
D
R
E
L
N
E
V
I
N
Q
M
E
T
S
D
Q
L
L
Q
R
L
N
D
M
N
T
E
I
S
G
L
K
N
V
N
K
R
A
F
E
N
F
K
K
F
N
E
R
R
K
D
L
A
E
R
A
S
E
L
D
E
S
K
D
S
I
Q
D
L
I
V
K
L
K
Q
Q
K
V
N
A
V
D
S
T
F
Q
K
V
S
E
N
F
E
A
V
F
E
R
L
V
P
R
G
T
A
K
L
I
I
H
---------
S
I
S
V
S
F
N
S
K
Q
N
E
Q
L
H
V
E
Q
L
S
G
G
Q
K
T
V
C
A
I
A
L
I
L
A
I
Q
M
V
D
P
A
S
F
Y
L
F
D
E
I
D
A
A
L
D
K
Q
Y
R
T
A
V
A
T
L
L
K
E
L
S
K
N
A
Q
F
I
C
T
T
F
R
T
D
M
L
Q
V
A
D
K
F
F
R
V
K
Y
E
N
K
-
I
S
T
V
I
E
V
N
R
E
E
A
I
G
F
I
R
96
Fugue
60.32
29%
62
- C2 -
-
1E69
-
?
A:
[1-1164]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
R
L
K
K
L
Y
L
K
GFKSFG
R
P
S
L
I
G
F
S
D
R
V
T
A
I
V
G
P
N
G
S
G
K
S
N
I
I
D
A
I
K
W
V
F
G
E
K
F
D
M
I
F
A
G
S
E
N
L
P
P
A
G
S
A
Y
V
E
L
V
F
E
E
N
G
E
E
I
T
V
A
R
E
L
K
R
T
G
E
N
T
Y
Y
L
N
G
S
P
V
R
L
K
D
I
R
D
R
F
A
G
T
G
L
G
V
D
F
Y
S
I
V
G
Q
G
Q
I
D
R
I
V
N
A
Y
Q
R
V
N
E
S
F
N
R
F
I
S
L
L
F
F
G
G
E
G
R
L
--------------
E
I
S
I
R
K
P
G
R
R
D
Q
K
L
S
L
L
S
G
G
E
K
A
L
V
G
L
A
L
L
F
A
L
M
E
I
K
P
S
P
F
Y
V
L
D
E
V
D
S
P
L
D
D
Y
N
A
E
R
F
K
R
L
L
K
E
N
S
K
H
T
Q
F
I
V
I
T
H
N
K
I
V
M
E
A
A
D
L
L
H
G
V
T
M
V
N
-
G
V
S
A
I
V
P
V
E
V
--------
6
PsiBlast_PDB
60.31
47%
-120
- C2 -
-
1XEX
1
?
B:
[4-152]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
K
N
V
F
M
R
T
F
E
A
I
S
R
N
F
S
E
I
F
A
K
L
S
P
G
G
S
A
R
L
I
L
E
N
----
P
F
S
G
G
L
E
I
E
A
K
P
A
G
K
D
V
K
R
I
E
A
M
S
G
G
E
K
A
L
T
A
L
A
F
V
F
A
I
Q
K
F
K
P
A
P
F
Y
L
F
D
Q
I
D
A
H
L
D
D
A
N
V
K
R
V
A
D
L
I
K
E
S
S
K
E
S
Q
F
I
V
I
T
L
R
D
V
M
M
A
N
A
D
K
I
I
G
V
S
M
R
D
-
G
V
S
K
V
V
S
L
S
L
--------
84
HHSearch
60.22
30%
-174
- C3 -
-
1GXJ
-
?
A:
[514-658]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
G
L
V
D
V
V
S
N
L
I
E
V
-
D
E
K
Y
S
L
A
V
S
V
L
L
G
G
T
A
Q
N
I
V
V
R
N
V
D
T
A
K
A
I
V
E
F
L
K
Q
N
E
A
-
G
R
V
T
I
L
P
L
D
L
I
D
G
S
F
N
R
I
S
----
G
L
E
N
E
R
G
F
V
G
Y
A
V
D
L
V
K
F
P
S
D
L
E
V
L
G
G
F
L
F
G
N
S
V
V
V
E
T
L
D
D
A
I
R
M
K
K
K
Y
R
L
N
T
R
I
A
T
L
D
G
E
L
I
S
G
R
G
A
I
T
G
G
R
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
88
HHSearch
58.96
32%
-5
- C2 -
-
5XEI
-
?
A:
[2-178]
P
Y
I
E
K
L
E
L
K
G
F
K
S
Y
G
N
R
K
V
V
I
P
-
F
S
K
G
F
T
A
I
V
G
A
N
G
S
G
K
S
N
I
G
D
A
I
L
F
V
L
G
G
L
S
A
K
A
M
R
A
T
R
I
S
D
L
I
F
A
G
S
K
G
E
P
P
A
K
Y
A
E
V
A
I
Y
F
N
N
E
D
-
R
G
F
P
I
D
E
D
E
V
V
I
K
R
R
V
Y
P
D
G
R
S
A
Y
W
L
N
G
R
R
A
T
R
S
E
I
L
D
L
L
S
A
A
M
I
S
P
E
G
Y
N
L
V
L
Q
G
D
I
T
K
F
I
K
M
S
P
L
E
R
R
Q
L
I
D
E
I
S
G
I
A
E
Y
D
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
83
HHSearch
56.72
32%
-3
- C2 -
-
3KTA
1
?
C:
[2-169]
P
Y
I
E
K
L
E
L
K
G
F
K
S
Y
G
N
K
K
V
V
I
P
-
F
S
K
G
F
T
A
I
V
G
A
N
G
S
G
K
S
N
I
G
D
A
I
L
F
V
L
G
G
L
S
A
K
A
M
R
A
S
R
I
S
D
L
I
F
A
-----
P
P
A
K
Y
A
E
V
A
I
Y
F
N
N
E
D
-
R
G
F
P
I
D
E
D
E
V
V
I
R
R
R
V
Y
P
D
G
R
S
S
Y
W
L
N
G
R
R
A
T
R
S
E
I
L
D
I
L
T
A
A
M
I
S
P
D
G
Y
N
I
V
L
Q
G
D
I
T
K
F
I
K
M
S
P
L
E
R
R
L
L
I
D
D
I
S
G
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
56.61
32%
-34
- C3 -
-
4RSJ
-
SMC_PYRFU
A:
[519-696]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
G
I
Y
G
T
L
A
E
L
I
K
V
K
D
E
A
Y
A
L
A
I
E
V
A
L
G
N
R
A
D
N
V
V
V
E
D
E
L
V
A
E
K
A
I
K
Y
L
K
E
H
K
L
-
G
R
L
T
F
L
P
L
N
K
I
K
P
K
H
V
D
S
---------
S
V
G
L
--
P
A
V
D
V
I
E
Y
D
Q
K
I
E
N
A
V
K
F
A
L
G
D
T
V
I
V
N
S
M
E
E
A
R
P
H
I
----
G
K
V
R
M
V
T
I
E
G
E
L
Y
E
R
S
G
A
I
T
G
G
H
F
---LAV
D
T
T
K
-
L
R
E
K
-
V
E
S
L
R
R
R
K
E
A
L
E
G
E
L
N
S
L
K
I
E
L
R
S
L
E
N
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
56.26
25%
-24
- C3 -
-
4RSI
-
A:
[98-311]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
C
K
N
S
E
Y
L
K
R
R
V
T
N
L
E
F
N
Y
T
K
P
Y
P
N
F
E
A
S
F
-----
V
H
G
V
V
G
Q
L
F
Q
I
D
N
D
-
N
I
R
Y
A
T
A
L
Q
T
C
A
G
G
R
L
F
N
V
V
V
Q
D
S
Q
T
A
T
Q
---
L
L
E
R
G
R
L
R
K
R
V
T
I
I
P
L
D
K
I
Y
T
R
P
I
S
S
Q
V
L
D
L
A
K
K
I
A
P
G
K
V
E
L
A
I
N
L
I
R
F
D
E
S
I
T
K
A
M
E
F
I
F
G
N
S
L
I
C
E
D
P
E
T
A
K
K
I
T
F
H
P
K
I
R
A
R
S
I
T
L
Q
G
D
V
Y
D
P
E
G
T
L
S
G
G
S
R
------
E
S
L
L
-
V
D
I
Q
K
Y
N
Q
I
Q
K
Q
I
E
T
I
Q
A
D
L
N
H
V
T
E
E
L
Q
T
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
PsiBlast_CBE
54.33
33%
3
- C2 -
-
1XEX
1
?
A:
[3-167]
-
Y
I
E
K
L
E
L
K
G
F
K
S
Y
G
N
K
-
K
V
V
I
P
F
S
K
G
F
T
A
I
V
G
A
N
G
S
G
K
S
N
I
G
D
A
I
L
F
V
L
G
G
L
S
A
K
A
M
R
A
S
R
I
S
D
L
I
F
A
G
S
K
N
E
P
P
A
K
Y
A
E
V
A
I
Y
F
N
N
E
D
R
G
F
P
I
D
E
-
D
E
V
V
I
R
R
R
V
Y
P
D
G
R
S
S
Y
W
L
N
G
R
R
A
T
R
S
E
I
L
D
I
L
T
A
A
M
I
S
P
D
G
Y
N
I
V
L
Q
G
D
I
T
K
F
I
K
M
S
P
L
E
R
R
L
L
I
D
D
I
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------