@TOME V2.3
(Mar 2018)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : spr1128: (2018-01-05 )
MLNEFPIFDYEDIQLIPNKCVIKSRAEADTSVTLGNHTFKLPVVPANMQTILDENVAEQLAKGGYFYIMHRFDEAGRIPFIKRMHDQGLIASISVGVKDYEYDFVSQLKADAPEYITIDIAHGHADSVISMIQHIKKELPDTFVIAGNVGTPEAVRELENAGADATKVGIGPGKVCITKVKTGFGTGGWQLAALRWCAKAARKPIIADGGIRTHGDIAKSIRFGASMIMIGSLFAGHIESPGKTIEVDGEQFKEYYGSASQYQKGAYKNVEGKRILLPAKGHLQDTLTEMEQDLQSAISYAGGRQVADLKHVDYVIVKNSIWNGDASH
Atome Classification :
(24 SA)
.........10........20........30....-..-..40........50........60........70.----..-.---------..---..80..--------------.-------..----------...90........100.......110-........120.......130.......140.....--..150.......160.......170.......180--.......190.......200-.---..---......210.......220.......230.......240.......250.......260-------....-.....270........280.......290.......300.......310........320......
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MLNEFPIFDY
E
D
IQLIPN
K
C
V
IKSRAEAD
T
S
V
T
LG-N
H
-
T
F
K
L
PVVP
A
N
M
Q
T
I
L
D
E
N
V
A
E
Q
L
AKG
G
Y
F
Y
I
M
H
RF----DE-A---------GR---
I
P
F
I
K
R
--------------M-------HD----------QG
L
I
A
S
I
SVGVKD
Y
E
Y
D
F
V
S
Q
L
KAD--AP
E
Y
I
T
I
D
IAHGH
A
D
S
V
I
S
M
I
Q
H
I
K
K
ELPD
T
F
V
I
AG--NVG
T
P
E
A
V
R
E
L
E
NAGADATKVGIGPG
K
V
C
I
T
K
VKT--GFGTGG
W
Q
L
A
A
L
R
W
C
A
K
A
---A---RK---
P
I
IADGGIR
T
H
G
D
I
A
K
S
I
RFG
A
S
M
I
M
I
G
S
L
F
A
GHIESPG
K
T
I
EV
D
G
E
Q
F
K
E
YYG
S
A
S
---------
Q
Y
QK-GAYKNV-EG
K
R
I
L
LPAKG
H
L
Q
D
T
L
T
E
M
E
Q
D
L
Q
S
A
I
S
YAGGR
Q
V
A
DLKH-
V
D
Y
V
I
V
KNSIWNGDASH
119
HHSearch
87.89
74%
-41
- C1 -
-
2A1Y
1
GUAC_BACAN
A:
[12-330]
-----
N
V
F
D
Y
E
D
I
Q
L
I
P
A
K
C
I
V
N
S
R
S
E
C
D
T
T
V
T
L
G
-
K
H
-
K
F
K
L
P
V
V
P
A
N
M
Q
T
I
I
D
E
R
I
A
T
Y
L
A
E
N
N
Y
F
Y
I
M
H
R
F
----
Q
P
-
E
---------
K
R
---
I
S
F
I
R
D
--------------
M
-------
Q
S
----------
R
G
L
I
A
S
I
S
V
G
V
K
E
D
E
Y
E
F
V
Q
Q
L
A
A
E
HL
T
P
E
Y
I
T
I
D
I
A
H
G
H
S
N
A
V
I
N
M
I
Q
H
I
K
K
H
L
P
E
S
F
V
I
A
G
--
N
V
G
T
P
E
A
V
R
E
L
E
N
A
G
A
D
A
T
K
V
G
I
G
P
G
K
V
C
I
T
K
I
K
T
GF
G
T
G
G
W
--
Q
L
A
A
L
R
W
C
A
K
A
---
A
---
S
K
---
P
I
I
A
D
G
G
I
R
T
N
G
D
V
A
K
S
I
R
F
G
A
T
M
V
M
I
G
S
L
F
A
G
H
E
E
S
P
G
E
T
I
E
K
---
L
Y
K
E
Y
F
G
S
----------------------------
F
V
E
H
K
G
S
L
E
D
T
L
I
E
M
E
Q
D
L
Q
S
S
I
S
Y
A
G
G
T
K
L
D
S
I
R
T
-
V
D
Y
V
V
V
K
N
S
I
F
------
1
PsiBlast_PDB
87.16
74%
-37
- C1 -
-
2A1Y
1
GUAC_BACAN
A:
[13-330]
------
V
F
D
Y
E
D
I
Q
L
I
P
A
K
C
I
V
N
S
R
S
E
C
D
T
T
V
T
L
G
-
K
H
-
K
F
K
L
P
V
V
P
A
N
M
Q
T
I
I
D
E
R
I
A
T
Y
L
A
E
N
N
Y
F
Y
I
M
H
R
F
----
Q
P
-
E
---------
K
R
---
I
S
F
I
R
D
--------------
M
-------
Q
S
----------
R
G
L
I
A
S
I
S
V
G
V
K
E
D
E
Y
E
F
V
Q
Q
L
A
A
E
HL
T
P
E
Y
I
T
I
D
I
A
H
G
H
S
N
A
V
I
N
M
I
Q
H
I
K
K
H
L
P
E
S
F
V
I
A
G
--
N
V
G
T
P
E
A
V
R
E
L
E
N
A
G
A
D
A
T
K
V
G
I
G
P
G
K
V
C
I
T
K
I
K
T
--
G
F
G
T
G
G
W
Q
L
A
A
L
R
W
C
A
K
A
---
A
---
S
K
---
P
I
I
A
D
G
G
I
R
T
N
G
D
V
A
K
S
I
R
F
G
A
T
M
V
M
I
G
S
L
F
A
G
H
E
E
S
P
G
E
T
I
E
K
---
L
Y
K
E
Y
F
G
S
----------------------------
F
V
E
H
K
G
S
L
E
D
T
L
I
E
M
E
Q
D
L
Q
S
S
I
S
Y
A
G
G
T
K
L
D
S
I
R
T
-
V
D
Y
V
V
V
K
N
S
I
F
------
52
PsiBlast_CBE
69.12
34%
-31
- C1 -
-
4QM1
3
?
D:
[35-357]
-------
L
T
F
D
D
V
L
L
V
P
A
K
S
D
V
L
P
R
E
V
S
V
K
T
V
L
S
E
-
S
L
-
Q
L
N
I
P
L
I
S
A
G
M
D
T
V
T
E
A
D
M
A
I
A
M
A
R
Q
G
G
L
G
I
I
H
K
N
MSIE
Q
Q
-
A
---------
E
Q
---
V
D
K
V
K
R
-----------------------
S
----------
G
G
L
L
V
G
A
A
V
G
V
T
A
D
A
M
T
R
I
D
A
L
V
K
A
--
S
V
D
A
I
V
L
D
T
A
H
G
H
S
Q
G
V
I
D
K
V
K
E
V
R
A
K
Y
P
S
L
N
I
I
A
G
--
N
V
A
T
A
E
A
T
K
A
L
I
E
A
G
A
N
V
V
K
V
G
I
G
P
G
S
I
C
T
T
R
V
V
A
--
G
V
G
V
--
P
Q
L
T
A
V
Y
D
C
A
T
E
---
A
---
R
K
HGI
P
V
I
A
D
G
G
I
K
Y
S
G
D
M
V
K
A
L
A
A
G
A
H
V
V
M
L
G
S
M
F
A
G
V
A
E
S
P
G
E
T
E
I
Y
Q
G
R
Q
F
K
V
Y
R
G
M
G
S
VGAME-------------
L
V
P
E
G
I
E
G
R
V
P
Y
K
G
P
L
A
D
T
V
H
Q
L
V
G
G
L
R
A
G
M
G
Y
C
G
A
Q
D
L
E
F
L
R
E
------------------
54
PsiBlast_CBE
68.76
34%
-25
- C1 -
-
4QM1
3
?
B:
[35-358]
-------
L
T
F
D
D
V
L
L
V
P
A
K
S
D
V
L
P
R
E
V
S
V
K
T
V
L
S
E
-
S
L
-
Q
L
N
I
P
L
I
S
A
G
M
D
T
V
T
E
A
D
M
A
I
A
M
A
R
Q
G
G
L
G
I
I
H
K
N
MS
I
E
Q
Q
-
A
---------
E
Q
---
V
D
K
V
K
R
-----------------------
S
----------
G
G
L
L
V
G
A
A
V
G
V
T
A
D
A
M
T
R
I
D
A
L
V
K
A
--
S
V
D
A
I
V
L
D
T
A
H
G
H
S
Q
G
V
I
D
K
V
K
E
V
R
A
K
Y
P
S
L
N
I
I
A
G
--
N
V
A
T
A
E
A
T
K
A
L
I
E
A
G
A
N
V
V
K
V
G
I
G
P
G
S
I
C
T
T
R
V
V
A
--
G
V
G
V
--
P
Q
L
T
A
V
Y
D
C
A
T
E
---
A
---
R
K
H
G
I
P
V
I
A
D
G
G
I
K
Y
S
G
D
M
V
K
A
L
A
A
G
A
H
V
V
M
L
G
S
M
F
A
G
V
A
E
S
P
G
E
T
E
I
Y
Q
G
R
Q
F
K
V
Y
R
G
M
G
S
V
G
A
M
E
K-----------
K
L
V
P
E
G
I
E
G
R
V
P
Y
K
G
P
L
A
D
T
V
H
Q
L
V
G
G
L
R
A
G
M
G
Y
C
G
A
Q
D
L
E
F
L
R
E
------------------
47
PsiBlast_CBE
68.18
34%
-27
- C1 -
-
5URR
2
?
F:
[35-353]
-------
L
T
F
D
D
V
L
L
V
P
A
K
S
D
V
L
P
R
E
V
S
V
K
T
V
L
S
E
-
S
L
-
Q
L
N
I
P
L
I
S
A
G
M
D
T
V
T
E
A
D
M
A
I
A
M
A
R
Q
G
G
L
G
I
I
H
K
N
MS
I
E
Q
Q
-
A
---------
E
Q
---
V
D
K
V
K
R
-----------------------
S
----------
G
G
L
L
V
G
A
A
V
G
V
T
A
D
A
M
T
R
I
D
A
L
V
K
A
--
S
V
D
A
I
V
L
D
T
A
H
G
H
S
Q
G
V
I
D
K
V
K
E
V
R
A
K
Y
P
S
L
N
I
I
A
G
--
N
V
A
T
A
E
A
T
K
A
L
I
E
A
G
A
N
V
V
K
V
G
I
G
P
G
S
I
C
T
T
R
V
V
A
--
G
V
G
V
--
P
Q
L
T
A
V
Y
D
C
A
T
E
---
A
---
R
K
H
G
I
P
V
I
A
D
G
G
I
K
Y
S
G
D
M
V
K
A
L
A
A
G
A
H
V
V
M
L
G
S
M
F
A
G
V
A
E
S
P
G
E
T
E
I
Y
Q
G
R
Q
F
K
V
Y
R
G
M
G
S
V
G
A
M
E
KGSK--------
K
L
V
P
E
G
I
E
G
R
V
P
Y
K
G
P
L
A
D
T
V
H
Q
L
V
G
G
L
R
A
G
M
G
Y
C
G
A
Q
D
L
E
F
L
R
E
------------------
44
PsiBlast_CBE
66.95
34%
-28
- C1 -
-
5URS
3
?
B:
[35-353]
-------
L
T
F
D
D
V
L
L
V
P
A
K
S
D
V
L
P
R
E
V
S
V
K
T
V
L
S
E
-
S
L
-
Q
L
N
I
P
L
I
S
A
G
M
D
T
V
T
E
A
D
M
A
I
A
M
A
R
Q
G
G
L
G
I
I
H
K
N
MS
I
E
Q
Q
-
A
---------
E
Q
---
V
D
K
V
K
R
-----------------------
S
----------
G
G
L
L
V
G
A
A
V
G
V
T
A
D
A
M
T
R
I
D
A
L
V
K
A
--
S
V
D
A
I
V
L
D
T
A
H
G
H
S
Q
G
V
I
D
K
V
K
E
V
R
A
K
Y
P
S
L
N
I
I
A
G
--
N
V
A
T
A
E
A
T
K
A
L
I
E
A
G
A
N
V
V
K
V
G
I
G
P
G
S
I
C
T
T
R
V
V
A
--
G
V
G
V
--
P
Q
L
T
A
V
Y
D
C
A
T
E
---
A
---
R
K
H
G
I
P
V
I
A
D
G
G
I
K
Y
S
G
D
M
V
K
A
L
A
A
G
A
H
V
V
M
L
G
S
M
F
A
G
V
A
E
S
P
G
E
T
E
I
Y
Q
G
R
Q
F
K
V
Y
R
G
M
G
S
V
G
A
M
E
K-----------
K
L
V
P
E
G
I
E
G
R
V
P
Y
K
G
P
L
A
D
T
V
H
Q
L
V
G
G
L
R
A
G
M
G
Y
C
G
A
Q
D
L
E
F
L
R
E
------------------
42
PsiBlast_CBE
66.83
34%
-24
- C1 -
-
5URS
4
?
D:
[35-353]
-------
L
T
F
D
D
V
L
L
V
P
A
K
S
D
V
L
P
R
E
V
S
V
K
T
V
L
S
E
-
S
L
-
Q
L
N
I
P
L
I
S
A
G
M
D
T
V
T
E
A
D
M
A
I
A
M
A
R
Q
G
G
L
G
I
I
H
K
N
MS
I
E
Q
Q
-
A
---------
E
Q
---
V
D
K
V
K
R
-----------------------
S
----------
G
G
L
L
V
G
A
A
V
G
V
T
A
D
A
M
T
R
I
D
A
L
V
K
A
--
S
V
D
A
I
V
L
D
T
A
H
G
H
S
Q
G
V
I
D
K
V
K
E
V
R
A
K
Y
P
S
L
N
I
I
A
G
--
N
V
A
T
A
E
A
T
K
A
L
I
E
A
G
A
N
V
V
K
V
G
I
G
P
G
S
I
C
T
T
R
V
V
A
--
G
V
G
V
--
P
Q
L
T
A
V
Y
D
C
A
T
E
---
A
---
R
K
H
G
I
P
V
I
A
D
G
G
I
K
Y
S
G
D
M
V
K
A
L
A
A
G
A
H
V
V
M
L
G
S
M
F
A
G
V
A
E
S
P
G
E
T
E
I
Y
Q
G
R
Q
F
K
V
Y
R
G
M
G
S
VGAME-------------
L
V
P
E
G
I
E
G
R
V
P
Y
K
G
P
L
A
D
T
V
H
Q
L
V
G
G
L
R
A
G
M
G
Y
C
G
A
Q
D
L
E
F
L
R
E
------------------
41
PsiBlast_CBE
66.47
34%
-27
- C1 -
-
5URS
2
?
E:
[35-353]
-------
L
T
F
D
D
V
L
L
V
P
A
K
S
D
V
L
P
R
E
V
S
V
K
T
V
L
S
E
-
S
L
-
Q
L
N
I
P
L
I
S
A
G
M
D
T
V
T
E
A
D
M
A
I
A
M
A
R
Q
G
G
L
G
I
I
H
K
N
MSIE
Q
Q
-
A
---------
E
Q
---
V
D
K
V
K
R
-----------------------
S
----------
G
G
L
L
V
G
A
A
V
G
V
T
A
D
A
M
T
R
I
D
A
L
V
K
A
--
S
V
D
A
I
V
L
D
T
A
H
G
H
S
Q
G
V
I
D
K
V
K
E
V
R
A
K
Y
P
S
L
N
I
I
A
G
--
N
V
A
T
A
E
A
T
K
A
L
I
E
A
G
A
N
V
V
K
V
G
I
G
P
G
S
I
C
T
T
R
V
V
A
--
G
V
G
V
--
P
Q
L
T
A
V
Y
D
C
A
T
E
---
A
---
R
K
HGI
P
V
I
A
D
G
G
I
K
Y
S
G
D
M
V
K
A
L
A
A
G
A
H
V
V
M
L
G
S
M
F
A
G
V
A
E
S
P
G
E
T
E
I
Y
Q
G
R
Q
F
K
V
Y
R
G
M
G
S
VGAMEK-------------
V
P
E
G
I
E
G
R
V
P
Y
K
G
P
L
A
D
T
V
H
Q
L
V
G
G
L
R
A
G
M
G
Y
C
G
A
Q
D
L
E
F
L
R
E
------------------
50
PsiBlast_CBE
66.45
34%
-29
- C1 -
-
5URR
3
?
C:
[35-353]
-------
L
T
F
D
D
V
L
L
V
P
A
K
S
D
V
L
P
R
E
V
S
V
K
T
V
L
S
E
-
S
L
-
Q
L
N
I
P
L
I
S
A
G
M
D
T
V
T
E
A
D
M
A
I
A
M
A
R
Q
G
G
L
G
I
I
H
K
N
MS
I
E
Q
Q
-
A
---------
E
Q
---
V
D
K
V
K
R
-----------------------
S
----------
G
G
L
L
V
G
A
A
V
G
V
T
A
D
A
M
T
R
I
D
A
L
V
K
A
--
S
V
D
A
I
V
L
D
T
A
H
G
H
S
Q
G
V
I
D
K
V
K
E
V
R
A
K
Y
P
S
L
N
I
I
A
G
--
N
V
A
T
A
E
A
T
K
A
L
I
E
A
G
A
N
V
V
K
V
G
I
G
P
G
S
I
C
T
T
R
V
V
A
--
G
V
G
V
--
P
Q
L
T
A
V
Y
D
C
A
T
E
---
A
---
R
K
H
G
I
P
V
I
A
D
G
G
I
K
Y
S
G
D
M
V
K
A
L
A
A
G
A
H
V
V
M
L
G
S
M
F
A
G
V
A
E
S
P
G
E
T
E
I
Y
Q
G
R
Q
F
K
V
Y
R
G
M
G
S
V
G
A
M
E
KGS----------
L
V
P
E
G
I
E
G
R
V
P
Y
K
G
P
L
A
D
T
V
H
Q
L
V
G
G
L
R
A
G
M
G
Y
C
G
A
Q
D
L
E
F
L
R
E
------------------
32
PsiBlast_CBE
66.33
34%
-25
- C1 -
-
5UUW
3
?
D:
[35-353]
-------
L
T
F
D
D
V
L
L
V
P
A
K
S
D
V
L
P
R
E
V
S
V
K
T
V
L
S
E
-
S
L
-
Q
L
N
I
P
L
I
S
A
G
M
D
T
V
T
E
A
D
M
A
I
A
M
A
R
Q
G
G
L
G
I
I
H
K
N
MS
I
E
Q
Q
-
A
---------
E
Q
---
V
D
K
V
K
R
-----------------------
S
----------
G
G
L
L
V
G
A
A
V
G
V
T
A
D
A
M
T
R
I
D
A
L
V
K
A
--
S
V
D
A
I
V
L
D
T
A
H
G
H
S
Q
G
V
I
D
K
V
K
E
V
R
A
K
Y
P
S
L
N
I
I
A
G
--
N
V
A
T
A
E
A
T
K
A
L
I
E
A
G
A
N
V
V
K
V
G
I
G
P
G
S
I
C
T
T
R
V
V
A
--
G
V
G
V
--
P
Q
L
T
A
V
Y
D
C
A
T
E
---
A
---
R
K
H
G
I
P
V
I
A
D
G
G
I
K
Y
S
G
D
M
V
K
A
L
A
A
G
A
H
V
V
M
L
G
S
M
F
A
G
V
A
E
S
P
G
E
T
E
I
Y
Q
G
R
Q
F
K
V
Y
R
G
M
G
S
V
G
A
M
E
K-----------
K
L
V
P
E
G
I
E
G
R
V
P
Y
K
G
P
L
A
D
T
V
H
Q
L
V
G
G
L
R
A
G
M
G
Y
C
G
A
Q
D
L
E
F
L
R
E
------------------
66
PsiBlast_CBE
66.20
34%
-27
- C1 -
-
4MY9
2
?
E:
[35-353]
-------
L
T
F
D
D
V
L
L
V
P
A
K
S
D
V
L
P
R
E
V
S
V
K
T
V
L
S
E
-
S
L
-
Q
L
N
I
P
L
I
S
A
G
M
D
T
V
T
E
A
D
M
A
I
A
M
A
R
Q
G
G
L
G
I
I
H
K
N
MS
I
E
Q
Q
-
A
---------
E
Q
---
V
D
K
V
K
R
-----------------------
S
----------
G
G
L
L
V
G
A
A
V
G
V
T
A
D
A
M
T
R
I
D
A
L
V
K
A
--
S
V
D
A
I
V
L
D
T
A
H
G
H
S
Q
G
V
I
D
K
V
K
E
V
R
A
K
Y
P
S
L
N
I
I
A
G
--
N
V
A
T
A
E
A
T
K
A
L
I
E
A
G
A
N
V
V
K
V
G
I
G
P
G
S
I
C
T
T
R
V
V
A
--
G
V
G
V
--
P
Q
L
T
A
V
Y
D
C
A
T
E
---
A
---
R
K
H
G
I
P
V
I
A
D
G
G
I
K
Y
S
G
D
M
V
K
A
L
A
A
G
A
H
V
V
M
L
G
S
M
F
A
G
V
A
E
S
P
G
E
T
E
I
Y
Q
G
R
Q
F
K
V
Y
R
G
M
G
S
V
G
A
M
E
K------------
L
V
P
E
G
I
E
G
R
V
P
Y
K
G
P
L
A
D
T
V
H
Q
L
V
G
G
L
R
A
G
M
G
Y
C
G
A
Q
D
L
E
F
L
R
E
------------------
70
PsiBlast_CBE
66.17
34%
-29
- C1 -
-
4MY8
7
?
D:
[35-353]
-------
L
T
F
D
D
V
L
L
V
P
A
K
S
D
V
L
P
R
E
V
S
V
K
T
V
L
S
E
-
S
L
-
Q
L
N
I
P
L
I
S
A
G
M
D
T
V
T
E
A
D
M
A
I
A
M
A
R
Q
G
G
L
G
I
I
H
K
N
MSIE
Q
Q
-
A
---------
E
Q
---
V
D
K
V
K
R
-----------------------
S
----------
G
G
L
L
V
G
A
A
V
G
V
T
A
D
A
M
T
R
I
D
A
L
V
K
A
--
S
V
D
A
I
V
L
D
T
A
H
G
H
S
Q
G
V
I
D
K
V
K
E
V
R
A
K
Y
P
S
L
N
I
I
A
G
--
N
V
A
T
A
E
A
T
K
A
L
I
E
A
G
A
N
V
V
K
V
G
I
G
P
G
S
I
C
T
T
R
V
V
A
--
G
V
G
V
--
P
Q
L
T
A
V
Y
D
C
A
T
E
---
A
---
R
K
HGI
P
V
I
A
D
G
G
I
K
Y
S
G
D
M
V
K
A
L
A
A
G
A
H
V
V
M
L
G
S
M
F
A
G
V
A
E
S
P
G
E
T
E
I
Y
Q
G
R
Q
F
K
V
Y
R
G
M
G
S
VGAMEKGSK---------
L
V
P
E
G
I
E
G
R
V
P
Y
K
G
P
L
A
D
T
V
H
Q
L
V
G
G
L
R
A
G
M
G
Y
C
G
A
Q
D
L
E
F
L
R
E
------------------
6
PsiBlast_PDB
66.17
34%
-28
- C1 -
-
4MYX
5
?
A:
[35-353]
-------
L
T
F
D
D
V
L
L
V
P
A
K
S
D
V
L
P
R
E
V
S
V
K
T
V
L
S
E
-
S
L
-
Q
L
N
I
P
L
I
S
A
G
M
D
T
V
T
E
A
D
M
A
I
A
M
A
R
Q
G
G
L
G
I
I
H
K
N
MS
I
E
Q
Q
-
A
---------
E
Q
---
V
D
K
V
K
R
-----------------------
S
----------
G
G
L
L
V
G
A
A
V
G
V
T
A
D
A
M
T
R
I
D
A
L
V
K
A
--
S
V
D
A
I
V
L
D
T
A
H
G
H
S
Q
G
V
I
D
K
V
K
E
V
R
A
K
Y
P
S
L
N
I
I
A
G
--
N
V
A
T
A
E
A
T
K
A
L
I
E
A
G
A
N
V
V
K
V
G
I
G
P
G
S
I
C
T
T
R
V
V
A
--
G
V
G
V
--
P
Q
L
T
A
V
Y
D
C
A
T
E
---
A
---
R
K
H
G
I
P
V
I
A
D
G
G
I
K
Y
S
G
D
M
V
K
A
L
A
A
G
A
H
V
V
M
L
G
S
M
F
A
G
V
A
E
S
P
G
E
T
E
I
Y
Q
G
R
Q
F
K
V
Y
R
G
M
G
S
V
G
A
M
E
K-----------
K
L
V
P
E
G
I
E
G
R
V
P
Y
K
G
P
L
A
D
T
V
H
Q
L
V
G
G
L
R
A
G
M
G
Y
C
G
A
Q
D
L
E
F
L
R
E
------------------
59
PsiBlast_CBE
66.13
34%
-31
- C1 -
-
4MYX
2
?
D:
[35-353]
-------
L
T
F
D
D
V
L
L
V
P
A
K
S
D
V
L
P
R
E
V
S
V
K
T
V
L
S
E
-
S
L
-
Q
L
N
I
P
L
I
S
A
G
M
D
T
V
T
E
A
D
M
A
I
A
M
A
R
Q
G
G
L
G
I
I
H
K
N
MS
I
E
Q
Q
-
A
---------
E
Q
---
V
D
K
V
K
R
-----------------------
S
----------
G
G
L
L
V
G
A
A
V
G
V
T
A
D
A
M
T
R
I
D
A
L
V
K
A
--
S
V
D
A
I
V
L
D
T
A
H
G
H
S
Q
G
V
I
D
K
V
K
E
V
R
A
K
Y
P
S
L
N
I
I
A
G
--
N
V
A
T
A
E
A
T
K
A
L
I
E
A
G
A
N
V
V
K
V
G
I
G
P
G
S
I
C
T
T
R
V
V
A
--
G
V
G
V
--
P
Q
L
T
A
V
Y
D
C
A
T
E
---
A
---
R
K
H
G
I
P
V
I
A
D
G
G
I
K
Y
S
G
D
M
V
K
A
L
A
A
G
A
H
V
V
M
L
G
S
M
F
A
G
V
A
E
S
P
G
E
T
E
I
Y
Q
G
R
Q
F
K
V
Y
R
G
M
G
S
V
G
A
M
E
K
G---------
K
K
L
V
P
E
G
I
E
G
R
V
P
Y
K
G
P
L
A
D
T
V
H
Q
L
V
G
G
L
R
A
G
M
G
Y
C
G
A
Q
D
L
E
F
L
R
E
------------------
48
PsiBlast_CBE
66.04
34%
-28
- C1 -
-
5URR
3
?
E:
[35-353]
-------
L
T
F
D
D
V
L
L
V
P
A
K
S
D
V
L
P
R
E
V
S
V
K
T
V
L
S
E
-
S
L
-
Q
L
N
I
P
L
I
S
A
G
M
D
T
V
T
E
A
D
M
A
I
A
M
A
R
Q
G
G
L
G
I
I
H
K
N
MS
I
E
Q
Q
-
A
---------
E
Q
---
V
D
K
V
K
R
-----------------------
S
----------
G
G
L
L
V
G
A
A
V
G
V
T
A
D
A
M
T
R
I
D
A
L
V
K
A
--
S
V
D
A
I
V
L
D
T
A
H
G
H
S
Q
G
V
I
D
K
V
K
E
V
R
A
K
Y
P
S
L
N
I
I
A
G
--
N
V
A
T
A
E
A
T
K
A
L
I
E
A
G
A
N
V
V
K
V
G
I
G
P
G
S
I
C
T
T
R
V
V
A
--
G
V
G
V
--
P
Q
L
T
A
V
Y
D
C
A
T
E
---
A
---
R
K
H
G
I
P
V
I
A
D
G
G
I
K
Y
S
G
D
M
V
K
A
L
A
A
G
A
H
V
V
M
L
G
S
M
F
A
G
V
A
E
S
P
G
E
T
E
I
Y
Q
G
R
Q
F
K
V
Y
R
G
M
G
S
V
G
A
M
E
K------------
L
V
P
E
G
I
E
G
R
V
P
Y
K
G
P
L
A
D
T
V
H
Q
L
V
G
G
L
R
A
G
M
G
Y
C
G
A
Q
D
L
E
F
L
R
E
------------------
31
PsiBlast_CBE
65.98
34%
-27
- C1 -
-
5UUW
2
?
E:
[35-353]
-------
L
T
F
D
D
V
L
L
V
P
A
K
S
D
V
L
P
R
E
V
S
V
K
T
V
L
S
E
-
S
L
-
Q
L
N
I
P
L
I
S
A
G
M
D
T
V
T
E
A
D
M
A
I
A
M
A
R
Q
G
G
L
G
I
I
H
K
N
MS
I
E
Q
Q
-
A
---------
E
Q
---
V
D
K
V
K
R
-----------------------
S
----------
G
G
L
L
V
G
A
A
V
G
V
T
A
D
A
M
T
R
I
D
A
L
V
K
A
--
S
V
D
A
I
V
L
D
T
A
H
G
H
S
Q
G
V
I
D
K
V
K
E
V
R
A
K
Y
P
S
L
N
I
I
A
G
--
N
V
A
T
A
E
A
T
K
A
L
I
E
A
G
A
N
V
V
K
V
G
I
G
P
G
S
I
C
T
T
R
V
V
A
--
G
V
G
V
--
P
Q
L
T
A
V
Y
D
C
A
T
E
---
A
---
R
K
H
G
I
P
V
I
A
D
G
G
I
K
Y
S
G
D
M
V
K
A
L
A
A
G
A
H
V
V
M
L
G
S
M
F
A
G
V
A
E
S
P
G
E
T
E
I
Y
Q
G
R
Q
F
K
V
Y
R
G
M
G
S
V
G
A
M
E
K-------------
V
P
E
G
I
E
G
R
V
P
Y
K
G
P
L
A
D
T
V
H
Q
L
V
G
G
L
R
A
G
M
G
Y
C
G
A
Q
D
L
E
F
L
R
E
------------------
12
PsiBlast_PDB
65.50
34%
-25
- C1 -
-
5UUZ
3
?
A:
[35-353]
-------
L
T
F
D
D
V
L
L
V
P
A
K
S
D
V
L
P
R
E
V
S
V
K
T
V
L
S
E
-
S
L
-
Q
L
N
I
P
L
I
S
A
G
M
D
T
V
T
E
A
D
M
A
I
A
M
A
R
Q
G
G
L
G
I
I
H
K
N
MS
I
E
Q
Q
-
A
---------
E
Q
---
V
D
K
V
K
R
-----------------------
S
----------
G
G
L
L
V
G
A
A
V
G
V
T
A
D
A
M
T
R
I
D
A
L
V
K
A
--
S
V
D
A
I
V
L
D
T
A
H
G
H
S
Q
G
V
I
D
K
V
K
E
V
R
A
K
Y
P
S
L
N
I
I
A
G
--
N
V
A
T
A
E
A
T
K
A
L
I
E
A
G
A
N
V
V
K
V
G
I
G
P
G
S
I
C
T
T
R
V
V
A
--
G
V
G
V
--
P
Q
L
T
A
V
Y
D
C
A
T
E
---
A
---
R
K
H
G
I
P
V
I
A
D
G
G
I
K
Y
S
G
D
M
V
K
A
L
A
A
G
A
H
V
V
M
L
G
S
M
F
A
G
V
A
E
S
P
G
E
T
E
I
Y
Q
G
R
Q
F
K
V
Y
R
G
M
G
S
V
G
A
M
E
K-------------
V
P
E
G
I
E
G
R
V
P
Y
K
G
P
L
A
D
T
V
H
Q
L
V
G
G
L
R
A
G
M
G
Y
C
G
A
Q
D
L
E
F
L
R
E
------------------
8
PsiBlast_PDB
65.49
34%
-28
- C1 -
-
5URR
3
?
A:
[35-353]
-------
L
T
F
D
D
V
L
L
V
P
A
K
S
D
V
L
P
R
E
V
S
V
K
T
V
L
S
E
-
S
L
-
Q
L
N
I
P
L
I
S
A
G
M
D
T
V
T
E
A
D
M
A
I
A
M
A
R
Q
G
G
L
G
I
I
H
K
N
MS
I
E
Q
Q
-
A
---------
E
Q
---
V
D
K
V
K
R
-----------------------
S
----------
G
G
L
L
V
G
A
A
V
G
V
T
A
D
A
M
T
R
I
D
A
L
V
K
A
--
S
V
D
A
I
V
L
D
T
A
H
G
H
S
Q
G
V
I
D
K
V
K
E
V
R
A
K
Y
P
S
L
N
I
I
A
G
--
N
V
A
T
A
E
A
T
K
A
L
I
E
A
G
A
N
V
V
K
V
G
I
G
P
G
S
I
C
T
T
R
V
V
A
--
G
V
G
V
--
P
Q
L
T
A
V
Y
D
C
A
T
E
---
A
---
R
K
H
G
I
P
V
I
A
D
G
G
I
K
Y
S
G
D
M
V
K
A
L
A
A
G
A
H
V
V
M
L
G
S
M
F
A
G
V
A
E
S
P
G
E
T
E
I
Y
Q
G
R
Q
F
K
V
Y
R
G
M
G
S
V
G
A
M
E
K----------
K
K
L
V
P
E
G
I
E
G
R
V
P
Y
K
G
P
L
A
D
T
V
H
Q
L
V
G
G
L
R
A
G
M
G
Y
C
G
A
Q
D
L
E
F
L
R
E
------------------
62
PsiBlast_CBE
65.33
34%
-22
- C1 -
-
4MYA
3
?
B:
[35-353]
-------
L
T
F
D
D
V
L
L
V
P
A
K
S
D
V
L
P
R
E
V
S
V
K
T
V
L
S
E
-
S
L
-
Q
L
N
I
P
L
I
S
A
G
M
D
T
V
T
E
A
D
M
A
I
A
M
A
R
Q
G
G
L
G
I
I
H
K
N
MS
I
E
Q
Q
-
A
---------
E
Q
---
V
D
K
V
K
R
-----------------------
S
----------
G
G
L
L
V
G
A
A
V
G
V
T
A
D
A
M
T
R
I
D
A
L
V
K
A
--
S
V
D
A
I
V
L
D
T
A
H
G
H
S
Q
G
V
I
D
K
V
K
E
V
R
A
K
Y
P
S
L
N
I
I
A
G
--
N
V
A
T
A
E
A
T
K
A
L
I
E
A
G
A
N
V
V
K
V
G
I
G
P
G
S
I
C
T
T
R
V
V
A
--
G
V
G
V
--
P
Q
L
T
A
V
Y
D
C
A
T
E
---
A
---
R
K
H
G
I
P
V
I
A
D
G
G
I
K
Y
S
G
D
M
V
K
A
L
A
A
G
A
H
V
V
M
L
G
S
M
F
A
G
V
A
E
S
P
G
E
T
E
I
Y
Q
G
R
Q
F
K
V
Y
R
G
M
G
S
V
G
A
M
E
K-----------
K
L
V
P
E
G
I
E
G
R
V
P
Y
K
G
P
L
A
D
T
V
H
Q
L
V
G
G
L
R
A
G
M
G
Y
C
G
A
Q
D
L
E
F
L
R
E
------------------
73
PsiBlast_CBE
65.19
34%
-27
- C1 -
-
4MY1
3
?
H:
[35-353]
-------
L
T
F
D
D
V
L
L
V
P
A
K
S
D
V
L
P
R
E
V
S
V
K
T
V
L
S
E
-
S
L
-
Q
L
N
I
P
L
I
S
A
G
M
D
T
V
T
E
A
D
M
A
I
A
M
A
R
Q
G
G
L
G
I
I
H
K
N
MSIE
Q
Q
-
A
---------
E
Q
---
V
D
K
V
K
R
-----------------------
S
----------
G
G
L
L
V
G
A
A
V
G
V
T
A
D
A
M
T
R
I
D
A
L
V
K
A
--
S
V
D
A
I
V
L
D
T
A
H
G
H
S
Q
G
V
I
D
K
V
K
E
V
R
A
K
Y
P
S
L
N
I
I
A
G
--
N
V
A
T
A
E
A
T
K
A
L
I
E
A
G
A
N
V
V
K
V
G
I
G
P
G
S
I
C
T
T
R
V
V
A
--
G
V
G
V
--
P
Q
L
T
A
V
Y
D
C
A
T
E
---
A
---
R
K
HGI
P
V
I
A
D
G
G
I
K
Y
S
G
D
M
V
K
A
L
A
A
G
A
H
V
V
M
L
G
S
M
F
A
G
V
A
E
S
P
G
E
T
E
I
Y
Q
G
R
Q
F
K
V
Y
R
G
M
G
S
VGAMEK------------
L
V
P
E
G
I
E
G
R
V
P
Y
K
G
P
L
A
D
T
V
H
Q
L
V
G
G
L
R
A
G
M
G
Y
C
G
A
Q
D
L
E
F
L
R
E
------------------
126
HHSearch
60.10
32%
-14
- C1 -
-
4FEZ
5
?
B:
[9-366]
--
I
A
K
E
A
L
T
F
D
D
V
L
L
V
P
A
H
S
T
V
-
L
P
N
T
A
D
L
R
T
R
L
T
K
N
I
-
A
L
N
I
P
M
V
S
A
S
M
D
T
V
T
E
A
R
L
A
I
A
L
A
Q
E
G
G
I
G
F
I
H
K
N
----
M
S
I
E
---------
Q
Q
A
A
Q
V
H
Q
V
K
I
FES------------KPN
A
C
K
D
E
Q
----------
G
R
L
R
V
G
A
A
V
G
A
A
P
G
N
E
E
R
V
K
A
L
V
E
A
--
G
V
D
V
L
L
I
D
S
S
H
G
H
S
E
G
V
L
Q
R
I
R
E
T
R
A
A
Y
P
H
L
E
I
I
G
G
--
N
V
A
T
A
E
G
A
R
A
L
I
E
A
G
V
S
A
V
K
V
G
I
G
P
G
S
I
C
T
T
R
I
V
T
--
G
V
G
V
P
--
Q
I
T
A
I
A
D
A
A
G
V
A
N
E
Y
---
G
I
---
P
V
I
A
D
G
G
I
R
F
S
G
D
I
S
K
A
I
A
A
G
A
S
C
V
M
V
G
S
M
F
A
G
T
E
E
A
P
G
E
V
I
L
Y
Q
G
R
S
Y
K
A
Y
------------------------------
G
R
I
A
Y
K
G
H
L
K
E
I
I
H
Q
Q
M
G
G
L
R
S
C
M
G
L
T
G
S
A
T
V
E
D
L
R
T
K
A
Q
F
V
R
I
S
G
A
--------
136
HHSearch
59.95
31%
-20
- C1 -
-
5AHN
1
?
A:
[3-467]
-
R
I
S
Q
E
A
L
T
F
D
D
V
L
L
I
P
G
Y
S
E
V
L
-
P
K
D
V
S
L
K
T
R
L
T
R
G
I
-
E
L
N
I
P
L
V
S
A
A
M
D
T
V
T
E
A
R
L
A
I
A
M
A
Q
E
G
G
I
G
I
I
H
K
N
----
M
G
I
E
Q
Q
A
A
E
V
R
K
V
K
K
H--------------------------------TYPL
A
S
K
D
EQ
G
R
L
R
V
G
A
A
V
G
T
G
A
D
T
G
E
R
V
A
A
L
V
A
A
--
G
V
D
V
V
V
V
D
T
A
H
G
H
S
K
G
V
I
E
R
V
R
W
V
K
Q
T
F
P
D
V
Q
V
I
G
G
--
N
I
A
T
A
E
A
A
K
A
L
A
E
A
G
A
D
A
V
K
V
G
I
G
P
G
S
I
C
T
T
R
I
V
A
--
G
V
G
V
P
--
Q
I
S
A
I
A
N
V
A
A
A
---
L
EGT
G
V
---
P
L
I
A
D
G
G
I
R
F
S
G
D
L
A
K
A
M
V
A
G
A
Y
C
V
M
M
G
S
M
F
A
G
T
E
E
A
P
G
-------------------------------------------------
G
A
L
S
A
I
V
H
Q
L
M
G
G
L
R
A
A
M
G
Y
T
G
S
A
D
I
Q
Q
M
R
T
Q
P
Q
F
V
R
I
T
G
A
--------
129
HHSearch
58.00
31%
5
- C1 -
-
5AHM
1
?
A:
[26-386]
----
Q
E
A
L
T
F
D
D
V
L
L
I
P
-
G
Y
S
E
V
L
P
K
D
V
S
L
K
T
R
L
T
R
G
I
-
E
L
N
I
P
L
V
S
A
A
M
D
T
V
T
E
A
R
L
A
I
A
M
A
Q
E
G
G
I
G
I
I
H
K
N
----
M
G
I
E
---------
Q
Q
A
A
E
V
R
K
V
K
K
H
E
T
A
KAKTYPLASK
D
-------
E
Q
----------
G
R
L
R
V
G
A
A
V
G
T
G
A
D
T
G
E
R
V
A
A
L
V
A
A
--
G
V
D
V
V
V
V
D
T
A
H
G
H
S
K
G
V
I
E
R
V
R
W
V
K
Q
T
F
P
D
V
Q
V
I
G
G
--
N
I
A
T
A
E
A
A
K
A
L
A
E
A
G
A
D
A
V
K
V
G
I
G
P
G
S
I
C
T
T
R
I
V
A
--
G
V
G
V
P
--
Q
I
S
A
I
A
N
V
A
A
A
---
L
EGT
G
V
---
P
L
I
A
D
G
G
I
R
F
S
G
D
L
A
K
A
M
V
A
G
A
Y
C
V
M
M
G
S
M
F
A
G
T
E
E
A
P
G
E
I
E
L
F
Q
G
R
S
Y
K
S
Y
R
G
M
G
S
L-----------------
V
P
-
E
G
I
E
G
R
V
P
Y
K
G
A
L
S
A
I
V
H
Q
L
M
G
G
L
R
A
A
M
G
Y
T
G
S
A
D
I
Q
Q
M
R
T
Q
P
Q
F
V
R
I
T
G
A
G
M
A
E
S
H
V
H
130
HHSearch
57.76
32%
-3
- C1 -
-
5K4X
2
?
A:
[26-368]
---
A
M
L
G
L
T
F
D
D
V
L
L
L
P
A
A
S
D
V
-
L
P
A
N
A
D
T
S
S
Q
L
T
-
K
K
I
R
L
K
V
P
L
V
S
S
A
M
D
T
V
T
E
A
R
M
A
I
A
M
A
R
A
G
G
M
G
V
L
H
R
N
----
L
P
V
A
---------
E
Q
---
A
A
Q
V
E
T
--------------
V
-------
K
R
S
---------
G
G
L
L
V
G
A
A
V
G
V
G
D
D
A
W
E
R
A
M
A
L
R
D
A
--
G
V
D
V
L
V
V
D
T
A
H
A
H
N
R
K
V
L
D
M
V
H
R
L
K
T
T
V
G
-
D
E
I
E
V
V
G
G
N
V
A
T
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A
A
A
A
A
L
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E
A
G
A
D
A
V
K
V
G
V
G
P
G
S
I
C
T
T
R
V
V
A
--
G
V
G
A
P
--
Q
I
T
A
I
L
E
A
V
A
A
C
A
P
H
---
G
V
---
P
V
I
A
D
G
G
L
Q
Y
S
G
D
I
A
K
A
L
A
A
G
A
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T
A
M
L
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S
L
L
A
G
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A
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S
P
G
E
L
I
L
V
N
G
K
Q
F
K
S
Y
R
G
M
G
S
---------
L
G
A
M
Q----
V
P
-
E
G
I
E
G
R
V
P
F
R
G
P
L
S
T
V
I
H
Q
L
V
G
G
L
R
A
A
M
G
Y
T
G
S
A
T
I
E
E
L
Q
Q
-
A
Q
F
V
Q
I
T
A
A
G
-------