@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : spr1147: (2018-01-06 )
MEKIIKEKISSLLSQEEEVLSVEQLGGMTNQNYLAKTTNKQYIVKFFGKGTEKLINRQDEKYNLELLKDLGLDVKNYLFDIEAGIKVNEYIESAITLDSTSIKTKFDKIAPILQTIHTSAKELRGEFAPFEEIKKYESLIEEQIPYANYESVRNAVFSLEKRLADLGVDRKSCHIDLVPENFIESPQGRLYLIDWEYSSMNDPMWDLAALFLESEFTSQEEETFLSHYESDQTPVSHEKIAIYKILQDTIWSLWTVYKEEQGEDFGDYGVNRYQRAVKGLASYGGSDEK
Atome Classification :
(20 SA)
-----------------------------------------.........10...-..----...20........30.....--..---------.----------40........50...--.....60...-.....70........80--........90.....-...-100-.---.....---..110....---.------..120...--------------.---.----.----.--------130------------.......140.---.-------------.--------.------------..---.---------150.......160----------------..------..---...170.......180-..--....------.-.190.......200.......210.-----------------.---------..------------------.------------------.-.220.-......-----230.--------------.-----------....-----------.240.......250......---.260-.-----.---...--...270.......280.......---
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
-----------------------------------------
M
E
K
I
I
K
E
K
I
S
S
L
L
S-Q
E
----
E
E
V
L
S
V
E
Q
LGGMTNQ
N
Y
L
AK--TT---------N----------
K
Q
Y
I
V
K
F
F
GK
G
T
E
K
L
--
I
NRQDEK
Y
N
L
-
E
L
L
K
D
LGL
D
V
K
N
Y
L
F
DI--EAGI
K
V
N
E
Y
I
E
S
A
I
T-LDS-TS--I---
K
T
K
F
D
---
K
I
A
P
I
L
Q
T
I
---
H
------
T
S
A
K
E
LRG--------------E---F----A----
P
--------
F
E
E
------------
I
K
K
Y
E
S
L
I
E
E
Q---I-------------P--------Y------------A
N
---
Y
---------
E
S
V
R
N
A
V
F
S
L
E
K
R
----------------
L
A
------
D
L---GVDRKS
C
H
I
D
LV
P
E
N
--FI--ESPQ------G-
R
L
Y
L
I
D
W
EYSSMND
P
M
W
D
L
A
A
L
F
L
E
-----------------S---------EF------------------T------------------
S
-
Q
E
E
E
T
-
F
L
S
H
YE-----SDQT--------------P-----------VS
H
E
-----------
K
I
A
I
Y
K
I
L
Q
D
T
I
W
S
L
W
T
V
Y
K
---
E
EQ--G-----E---D
F
G
--
D
Y
G
V
N
R
Y
Q
R
A
V
K
G
L
A
SYGGSDEK---
1
PsiBlast_PDB
95.07
100%
-84
- C1 -
-
4R77
-
?
B:
[1-283]
-----------------------------------------
M
E
K
I
I
K
E
K
I
S
S
L
L
----------
V
L
S
V
E
Q
L
G
G
M
T
N
Q
N
Y
L
A
K
--
T
T
---------
N
----------
K
Q
Y
I
V
K
F
F
G
K
G
T
E
K
L
--
I
N
R
Q
D
E
K
Y
N
L
-
E
L
L
K
D
L
G
L
D
V
K
N
Y
L
F
D
I
--
E
A
G
I
K
V
N
E
Y
I
E
S
A
I
T
-
L
D
S
-
T
S
--
I
---
K
T
K
F
D
---
K
I
A
P
I
L
Q
T
I
---
H
------
T
S
A
K
E
L
R
G
--------------
E
---
F
----
A
----
P
--------
F
E
E
------------
I
K
K
Y
E
S
L
I
E
E
Q
---
I
-------------
P
--------
Y
------------
A
N
---
Y
---------
E
S
V
R
N
A
V
F
S
L
E
K
R
----------------
L
A
------
D
L
---
G
V
D
R
K
S
C
H
I
D
L
V
P
E
N
--
F
I
--
E
S
P
Q
------
G
-
R
L
Y
L
I
D
W
E
Y
S
S
M
N
D
P
M
W
D
L
A
A
L
F
L
E
-----------------
S
---------
E
F
------------------
T
------------------
S
-
Q
E
E
E
T
-
F
L
S
H
Y
E
-----
S
D
Q
T
--------------
P
-----------
V
S
H
E
-----------
K
I
A
I
Y
K
I
L
Q
D
T
I
W
S
L
W
T
V
Y
K
---
E
E
Q
--
G
-----
E
---
D
F
G
--
D
Y
G
V
N
R
Y
Q
R
A
V
K
G
L
A
S
Y
---------
3
PsiBlast_PDB
93.59
100%
-71
- C1 -
-
4R7B
-
?
A:
[21-304]
-----------------------------------------
M
E
K
I
I
K
E
K
I
S
S
L
L
S
-
Q
E
----
E
E
V
L
S
V
E
Q
L
G
G
M
T
N
Q
N
Y
L
A
K
--
T
T
---------
N
----------
K
Q
Y
I
V
K
F
F
G
K
G
T
E
K
L
--
I
N
R
Q
D
E
K
Y
N
L
-
E
L
L
K
D
L
G
L
D
V
K
N
Y
L
F
D
I
--
E
A
G
I
K
V
N
E
Y
I
E
S
A
I
T
-
L
D
S
-
T
S
--
I
---
K
T
K
F
D
---
K
I
A
P
I
L
Q
T
I
---
H
------
T
S
A
K
E
L
R
G
--------------
E
---
F
----
A
----
P
--------
F
E
E
------------
I
K
K
Y
E
S
L
I
E
E
Q
---
I
-------------
P
--------
Y
------------
A
N
---
Y
---------
E
S
V
R
N
A
V
F
S
L
E
K
R
----------------
L
A
------
D
L
---
G
V
D
R
K
S
C
H
I
D
L
V
P
E
N
--
F
I
--
E
S
P
Q
------
G
-
R
L
Y
L
I
D
W
E
Y
S
S
M
N
D
P
M
W
D
L
A
A
L
F
L
E
-----------------
S
---------
E
F
------------------
T
------------------
S
-
Q
E
E
E
T
-
F
L
S
H
Y
E
-----
S
D
Q
T
--------------
P
-----------
V
S
H
E
-----------
K
I
A
I
Y
K
I
L
Q
D
T
I
W
S
L
W
T
V
Y
K
---
E
E
Q
--
G
-----
E
---
D
F
G
--
D
Y
G
V
N
R
Y
Q
R
A
V
K
G
L
A
S
Y
G
--------
2
PsiBlast_PDB
92.55
100%
-70
- C1 -
-
4R78
2
?
A:
[21-304]
-----------------------------------------
M
E
K
I
I
K
E
K
I
S
S
L
L
S
-
Q
E
----
E
E
V
L
S
V
E
Q
L
G
G
M
T
N
Q
N
Y
L
A
K
--
T
T
---------
N
----------
K
Q
Y
I
V
K
F
F
G
K
G
T
E
K
L
--
I
N
R
Q
D
E
K
Y
N
L
-
E
L
L
K
D
L
G
L
D
V
K
N
Y
L
F
D
I
--
E
A
G
I
K
V
N
E
Y
I
E
S
A
I
T
-
L
D
S
-
T
S
--
I
---
K
T
K
F
D
---
K
I
A
P
I
L
Q
T
I
---
H
------
T
S
A
K
E
L
R
G
--------------
E
---
F
----
A
----
P
--------
F
E
E
------------
I
K
K
Y
E
S
L
I
E
E
Q
---
I
-------------
P
--------
Y
------------
A
N
---
Y
---------
E
S
V
R
N
A
V
F
S
L
E
K
R
----------------
L
A
------
D
L
---
G
V
D
R
K
S
C
H
I
D
L
V
P
E
N
--
F
I
--
E
S
P
Q
------
G
-
R
L
Y
L
I
D
W
E
Y
S
S
M
N
D
P
M
W
D
L
A
A
L
F
L
E
-----------------
S
---------
E
F
------------------
T
------------------
S
-
Q
E
E
E
T
-
F
L
S
H
Y
E
-----
S
D
Q
T
--------------
P
-----------
V
S
H
E
-----------
K
I
A
I
Y
K
I
L
Q
D
T
I
W
S
L
W
T
V
Y
K
---
E
E
Q
--
G
-----
E
---
D
F
G
--
D
Y
G
V
N
R
Y
Q
R
A
V
K
G
L
A
S
Y
G
--------
21
HHSearch
80.85
97%
25
- C1 -
-
4R78
2
?
A:
[21-304]
-----------------------------------------
M
E
K
I
I
K
E
K
I
S
S
L
L
S
Q
E
E
----
E
V
L
S
V
E
Q
L
-
G
G
M
T
N
Q
N
Y
L
A
K
--
T
T
---------
N
----------
K
Q
Y
I
V
K
F
F
G
K
G
T
E
K
L
--
I
N
R
Q
D
E
K
Y
N
L
-
E
L
L
K
D
L
G
L
D
V
K
N
Y
L
F
D
I
--
E
A
G
I
K
V
N
E
Y
I
E
S
A
I
T
-
L
D
S
-
T
S
--
I
---
K
T
K
F
D
---
K
I
A
P
I
L
Q
T
I
---
H
------
T
S
A
K
E
L
R
G
--------------
E
---
F
----
A
----
P
--------
F
E
E
------------
I
K
K
Y
E
S
L
I
E
E
Q
---
I
-------------
P
--------
Y
------------
A
N
---
Y
---------
E
S
V
R
N
A
V
F
S
L
E
K
R
----------------
L
A
------
D
L
---
G
V
D
R
K
S
C
H
I
D
L
V
P
E
N
--
F
I
--
E
S
P
Q
------
G
-
R
L
Y
L
I
D
W
E
Y
S
S
M
N
D
P
M
W
D
L
A
A
L
F
L
E
-----------------
S
---------
E
F
------------------
T
------------------
S
-
Q
E
E
E
T
-
F
L
S
H
Y
E
-----
S
D
Q
T
--------------
P
-----------
V
S
H
E
-----------
K
I
A
I
Y
K
I
L
Q
D
T
I
W
S
L
W
T
V
Y
K
---
E
E
Q
--
G
-----
E
---
D
F
G
--
D
Y
G
V
N
R
Y
Q
R
A
V
K
G
L
A
S
Y
G
--------
27
HHSearch
54.52
25%
-4
- C1 -
-
3DXQ
-
?
B:
[4-288]
-------------------------------------------
D
E
A
R
A
K
L
A
A
I
P
M
-
L
A
----
G
Y
T
G
P
L
E
R
L
G
G
L
T
N
L
V
F
R
A
-------------------------
G
D
L
C
L
R
I
P
----------
N
R
A
N
E
A
V
A
A
-
R
E
A
A
K
A
G
V
S
P
E
V
L
H
V
D
P
--
A
T
G
V
M
V
T
R
Y
I
A
G
A
Q
T
-
M
S
P
-
E
K
--
F
K
T
R
P
G
S
P
A
---
R
A
G
E
A
F
R
K
L
---
H
------
G
S
G
A
V
F
P
F
--------------
R
---
F
----
E
----
L
--------
F
A
M
------------
I
D
D
Y
L
K
V
L
S
T
K
---
N
-------------
V
--------
T
------------
L
P
---
A
G
Y
-------
H
D
V
V
R
E
A
G
G
V
R
S
A
----------------
L
A
------
A
H
---
P
L
P
L
A
A
C
H
C
D
P
L
C
E
N
--
F
L
--
D
T
G
-------
E
-
R
M
W
I
V
D
W
E
Y
S
G
M
N
D
P
L
W
D
L
G
D
L
S
V
E
-----------------
G
---------
K
F
------------------
N
------------------
A
-
N
Q
D
E
E
-
L
M
R
A
Y
F
-----
G
G
E
A
--------------
R
P
----------
A
E
R
G
-----------
R
V
V
I
Y
K
A
M
C
D
L
L
W
T
L
W
G
L
I
Q
---
L
A
N
--
D
NPV--
D
---
D
F
R
--
A
Y
A
D
G
R
F
A
R
C
K
A
L
M
E
T
P
---------
26
HHSearch
49.86
25%
-6
- C- -
-
3DXQ
-
?
A:
[4-288]
-------------------------------------------
D
E
A
R
A
K
L
A
A
I
P
M
-
L
A
----
G
Y
T
G
P
L
E
R
L
G
G
L
T
N
L
V
F
R
A
-------------------------
G
D
L
C
L
R
I
P
G
K
----
Y
--
I
N
R
A
N
E
A
V
A
A
-
R
E
A
A
K
A
G
V
S
P
E
V
L
H
V
D
P
--
A
T
G
V
M
V
T
R
Y
I
A
G
A
Q
T
-
M
S
P
-
E
K
--
F
K
T
R
P
G
S
P
A
---
R
A
G
E
A
F
R
K
L
---
H
------
G
S
G
A
V
F
P
F
--------------
R
---
F
----
E
----
L
--------
F
A
M
------------
I
D
D
Y
L
K
V
L
S
-----
N
-------------
V
--------
T
------------
L
P
---
A
G
Y
-------
H
D
V
V
R
E
A
G
G
V
R
S
A
----------------
L
A
------
A
H
---
P
L
P
L
A
A
C
H
C
D
P
L
C
E
N
--
F
L
--
D
T
G
-------
E
-
R
M
W
I
V
D
W
E
Y
S
G
M
N
D
P
L
W
D
L
G
D
L
S
V
E
-----------------
G
---------
K
F
------------------
N
------------------
A
-
N
Q
D
E
E
-
L
M
R
A
Y
F
-----
G
G
E
A
--------------
R
P
----------
A
E
R
G
-----------
R
V
V
I
Y
K
A
M
C
D
L
L
W
T
L
W
G
L
I
Q
---
L
A
N
--
D
NPV--
D
---
D
F
R
--
A
Y
A
D
G
R
F
A
R
C
K
A
L
M
E
T
P
---------
25
HHSearch
48.00
23%
26
- C1 -
-
2QG7
-
?
A:
[110-455]
---------------------------------------------------------------
S
L
E
F
Q
I
I
N
G
--
T
N
I
L
I
K
V
K
--
D
M
SK-------
Q
----------
A
K
Y
L
I
R
L
Y
G
P
-
T
D
E
I
--
I
N
R
E
R
E
K
K
I
S
-
C
I
L
Y
N
K
N
I
A
K
K
I
Y
V
F
F
T
----
N
G
R
I
E
E
F
M
D
G
-
Y
A
-
L
S
R
-
E
D
--
I
K
N-
P
K
F
Q
K
---
L
I
A
K
N
L
K
L
L
---
H
------
D
I
K
L
N
E
N
L
Y
K
E
L
Q
V
T
QKVPGTR
P
---
S
----
F
----
L
--------
W
N
T
------------
I
W
K
Y
F
H
L
L
N
E
E
---
R
-------------
K
--------
K
ICSFDAKA
N
I
L
K
L
I
---
D
F
--------
D
V
L
R
D
S
I
V
E
V
E
S
L
----------------
C
K
------
R
E
---
N
S
P
I
V
L
C
H
C
D
L
L
S
S
N
--
I
I
--
N
T
V
G
E
G
----
D
-
S
I
S
F
I
D
F
E
Y
S
C
P
M
E
R
A
Y
D
I
A
N
H
F
N
E
-----------------
Y
AGFNCDWDL
T
P
------------------
S
------------------
K
-
E
E
E
Y
H
-
F
I
M
H
Y
L
-----
G
T
D
D
--------------
E
E
L
I
N
-------
Q
L
I
R
-----------
E
I
Q
P
F
Y
I
C
S
H
I
N
W
G
L
W
S
L
L
Q
---
G
M
H
--
S
-----
F
---
D
F
I
--
N
Y
G
M
T
R
L
T
A
S
C
L
P
I
F
R
----------
24
HHSearch
47.03
23%
19
- C1 -
-
2QG7
-
?
E:
[110-455]
---------------------------------------------------------------
S
L
E
F
Q
I
I
N
G
-
I
T
N
I
L
I
K
V
K
--
D
M
SK-------
Q
----------
A
K
Y
L
I
R
L
Y
G
P
K
T
D
E
I
--
I
N
R
E
R
E
K
K
I
S
-
C
I
L
Y
N
K
N
I
A
K
K
I
Y
V
F
F
T
----
N
G
R
I
E
E
F
M
D
G
-
Y
A
-
L
S
R
-
E
D
--
I
KN-
P
K
F
Q
K
---
L
I
A
K
N
L
K
L
L
---
H
------
D
I
K
L
N
E
N
L
YKELQVTQKVPGTR
P
---
S
----
F
----
L
--------
W
N
T
------------
I
W
K
Y
F
H
L
L
N
E
E
---
R
-------------
K
--------
K
ICSFDAKANILK
L
I
---
D
F--------
D
V
L
R
D
S
I
V
E
V
E
S
L
----------------
C
K
------
R
E
---
N
S
P
I
V
L
C
H
C
D
L
L
S
S
N
--
I
I
--
N
T
V
G
G-----
D
-
S
I
S
F
I
D
F
E
Y
S
C
P
M
E
R
A
Y
D
I
A
N
H
F
N
E
-----------------
Y
AGFNCDWDL
T
P
------------------
S
------------------
K
-
E
E
E
Y
H
-
F
I
M
H
Y
L
-----
G
T
D
D
--------------
E
ELIN-------
Q
L
I
R
-----------
E
I
Q
P
F
Y
I
C
S
H
I
N
W
G
L
W
S
L
L
Q
---
G
M
H
--
S
SD---
F
---
D
F
I
--
N
Y
G
M
T
R
L
T
A
S
C
L
P
I
F
R
----------
45
Fugue
46.84
21%
15
- C1 -
-
2QG7
-
?
A:
[50-458]
YPITESNLRILEGED
R
S
E
K
A
K
E
L
L
K
K
Y
VSNVFEN
E
K
T
L
Y
I
Y
C
K
Y
V
M
L
H
Y
G
K
D
L
V
N
-
P
N
----
E
V
D
S
L
E
F
Q
I
I
N
G
T
N
I
L
I
K
V
K
DM
S
K
---------
Q
----------
A
K
Y
L
I
R
L
Y
G
P
-
T
D
E
I
--
I
N
R
E
R
E
K
K
I
S
-
C
I
L
Y
N
K
N
I
A
K
K
-
I
Y
V
F
F
--
T
N
G
R
I
E
E
F
M
D
G
Y
A
L
S
-
R
E
D
-
I
K
--
N
---
P
K
F
Q
K
---
L
I
A
K
N
L
K
L
L
---
H
D
IKLN
E
N
L
Y
K
E
L
Q
V
--------------
T
---
Q
----
K
----
V
PGTRPSF
L
W
N
T
------------
I
W
K
Y
F
H
L
L
N
E
E
---
R
K
KICSFDAKA
N
I
L
K
--------
L
------------
I
D
---
F
---------
D
V
L
R
D
S
I
V
E
V
E
S
L
----------------
C
K
------
R
E
---
N
S
P
I
V
L
C
H
C
D
L
L
S
S
N
--
I
I
N
T
V
G
E
G
------
D
-
S
I
S
F
I
D
F
E
Y
S
C
P
M
E
R
A
Y
D
I
A
N
H
F
N
E
-----------------
Y
AGFNCDWDL
T
P
------------------
S
------------------
K
-
E
E
E
Y
H
-
F
I
M
H
Y
L
GTDD-
E
E
L
I
--------------
N
-----------
Q
L
I
R
-----------
E
I
Q
P
F
Y
I
C
S
H
I
N
W
G
L
W
S
L
L
Q
---
G
M
H
--
S
-----
F
---
D
F
I
--
N
Y
G
M
T
R
L
T
A
S
C
L
P
I
F
R
S
K
V
-------
4
PsiBlast_PDB
44.44
27%
1
- C- -
-
3DXQ
-
?
A:
[7-281]
----------------------------------------------
R
A
K
L
A
A
I
P
M
-
L
A
----
G
Y
T
G
P
L
E
R
L
G
G
L
T
N
L
V
F
R
A
G
-------------------------
D
L
C
L
R
I
P
G
K
----
Y
--
I
N
R
A
N
E
A
V
A
A
-
R
E
A
A
K
A
G
V
S
P
E
V
L
H
V
D
P
--
A
T
G
V
M
V
T
R
Y
I
A
G
A
Q
T
-
M
S
P
-
E
K
--
F
---
K
T
R
P
G
S
P
A
R
A
G
E
A
F
R
K
L
---
H
------
G
S
G
A
V
F
P
F
--------------
R
---
F
----
E
----
L
--------
F
A
M
------------
I
D
D
Y
L
K
V
L
S
--NVT
L
-------------
P
--------
A
------------
G
Y
---
H
---------
D
V
V
R
E
A
G
-
G
V
R
S
A
----------------
L
A
------
A
H
---
P
L
P
L
A
A
C
H
C
D
P
L
C
E
N
--
F
L
--
D
T
G
E
--------
R
M
W
I
V
D
W
E
Y
S
G
M
N
D
P
L
W
D
L
G
D
L
S
V
E
-----------------
G
---------
K
F
------------------
N
------------------
A
N
Q
D
E
E
L
-
M
R
A
Y
F
G
-----
G
E
A
R
--------------
P
-----------
A
E
R
G
-----------
R
V
V
I
Y
K
A
M
C
D
L
L
W
T
L
W
G
L
I
Q
L
A
N
D
N
P
--
V
-----
D
---
D
F
R
--
A
Y
A
D
G
R
F
A
R
C
----------------
29
HHSearch
43.82
18%
-8
- C1 -
-
3MES
2
?
B:
[74-410]
-----------------------------------------------------------------
E
V
K
Q
I
F
S
G
L
T
N
Q
L
F
V
V
S
--
I
V
---------
N
ELKH------
P
R
I
L
F
R
I
Y
G
K
H
V
--
F
--
Y
D
S
K
V
E
L
D
V
F
-
R
Y
L
S
N
I
N
I
A
P
N
I
I
A
D
F
----
P
E
G
R
I
E
E
F
I
D
G
E
-
P
-
L
T
T
-
K
Q
--
L
Q
L-
T
H
I
C
V
---
E
V
A
K
N
M
G
S
L
---
H
------
I
I
N
S
K
R
A
D
--------------
F
PSR
F
----
D
KEPI
L
--------
F
K
R
------------
I
Y
L
W
R
E
E
A
K
I
Q
---
V
S
K
NN---------
Q
--------
I
------------
D
K
E
L
-
Y
---------
S
K
I
L
E
E
I
D
Q
L
E
E
L
I
M
GGEKFS
M
E
R
A
L
E
L
K
L
Y
------
S
P
---
A
F
S
L
V
F
A
H
N
D
L
Q
E
N
N
--
L
L
--
Q
T
Q
-------
N
-
N
I
R
M
I
D
Y
E
Y
S
A
I
N
F
A
G
A
D
I
A
N
Y
F
C
E
-----------------
Y
---------
I
Y
------------------
D
YCSEKQPY
F
K
F
K
YEDYPC
E
-
E
L
R
K
L
-
F
I
S
V
Y
L
-----
S
Q
T
L
QEQVMPS-------
Q
Q
I
V
H
-------
I
M
T
K
-----------
A
V
E
V
F
T
L
I
S
H
I
T
W
G
L
W
S
I
A
-------SV
E
-----
F
---
D
F
T
--
E
Y
A
N
T
R
F
T
H
Y
L
Q
K
K
K
E
L
I
--------
30
HHSearch
42.17
18%
-5
- C1 -
-
3MES
3
?
A:
[74-410]
-----------------------------------------------------------------
E
V
K
Q
I
F
S
G
L
T
N
Q
L
F
V
V
S
--
I
V
---------
N
ELKH------
P
R
I
L
F
R
I
Y
G
K
H
V
-
K
F
--
Y
D
S
K
V
E
L
D
V
F
-
R
Y
L
S
N
I
N
I
A
P
N
I
I
A
D
F
----
P
E
G
R
I
E
E
F
I
D
G
E
-
P
-
L
T
T
-
K
Q
--
L
Q
L-
T
H
I
C
V
---
E
V
A
K
N
M
G
S
L
---
H
------
I
I
N
S
K
R
A
D
--------------
F
PSR
F
----
D
KEPI
L
--------
F
K
R
------------
I
Y
L
W
R
E
E
A
K
I
Q
---
V
S
K
NN------------------
I
------------
D
K
E
L
-
Y
---------
S
K
I
L
E
E
I
D
Q
L
E
E
L
I
M
GGEKFS
M
E
R
A
L
E
L
K
L
Y
------
S
P
---
A
F
S
L
V
F
A
H
N
D
L
Q
E
N
N
--
L
L
--
Q
T
Q
-------
N
-
N
I
R
M
I
D
Y
E
Y
S
A
I
N
F
A
G
A
D
I
A
N
Y
F
C
E
-----------------
Y
---------
I
Y
------------------
D
YCSEKQPY
F
K
F
K
YEDYPC
E
-
E
L
R
K
L
-
F
I
S
V
Y
L
-----
S
Q
T
L
QEQVMPS-------
Q
Q
I
V
H
-------
I
M
T
K
-----------
A
V
E
V
F
T
L
I
S
H
I
T
W
G
L
W
S
I
A
-------V-
E
-----
F
---
D
F
T
--
E
Y
A
N
T
R
F
T
H
Y
L
Q
K
K
K
E
L
I
--------
31
HHSearch
41.70
19%
32
* C1 *
-
5FUT
9
CHKA_HUMAN
A:
[32-377]
----------------------------------------------------------------
F
H
I
S
V
I
R
G
G
L
S
N
M
L
F
Q
C
S
--
L
P
---------
D
TTATLGDEP-
R
K
V
L
L
R
L
Y
G
------G
A
E
A
M
V
L
E
S
V
M
F
-
A
I
L
A
E
R
S
L
G
P
K
L
Y
G
I
F
----
P
Q
G
R
L
E
Q
F
I
P
S
R
-
R
-
L
D
T
-
E
E
--
L
SL-
P
D
I
S
A
---
E
I
A
E
K
M
A
T
F
---
H
------
G
M
K
M
P
F
N
K
--------------
E
---
P
K---
W
----
L
--------
F
G
T
------------
M
E
K
Y
L
K
E
V
L
R
I
---
K
-------------
F
TE
E
S
R
I
K
K
L
------------
H
K
---
L
L
S-------
Y
N
L
P
L
E
L
E
N
L
R
S
L
----------------
L
E
------
S
T
---
P
S
P
V
V
F
C
H
N
D
C
Q
E
G
N
--
I
L
--
L
L
E
G
RENSEK
Q
-
K
L
M
L
I
D
F
E
Y
S
S
Y
N
Y
R
G
F
D
I
G
N
H
F
C
E
-----------------
W
---------
M
Y
DYSYEKYPF
F
R
A
N
IRKYP
T
------------------
K
-
K
Q
Q
L
H
-
F
I
S
S
Y
L
-----
P
A
F
Q
NDFENLS
T
E
E
K
S
I
I
K
E
----------
E
M
L
L
-----------
E
V
N
R
F
A
L
A
S
H
F
L
W
G
L
W
S
I
V
Q
---
A
K
I
--
S
-----
S
IEF
G
Y
M
--
D
Y
A
Q
A
R
F
D
A
Y
F
H
Q
K
R
K
L
G
--------
19
PsiBlast_PDB
40.89
21%
25
- C1 -
-
3LQ3
2
CHKB_HUMAN
A:
[154-385]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
P
S
-
R
P
--
L
---
K
T
Q
E
L
---
R
E
P
V
L
S
A
A
I
---
A
------
T
K
M
A
Q
F
H
G
--------------
M
---
E
----
M
----
P
--------
F
T
K
EPHW
L
F
G
T
M
E
R
Y
L
K
Q
I
Q
D
L
P
P
T
G
---
L
-------------
P
--------
E
------------
M
N
L
L
E
M
---------
Y
S
L
K
D
E
M
G
N
L
R
K
L
----------------
L
E
------
S
T
---
P
S
P
V
V
F
C
H
N
D
I
Q
E
G
N
IL
L
L
--
S
E
P
--------D
S
L
M
L
V
D
F
E
Y
S
S
Y
N
Y
R
G
F
D
I
G
N
H
F
C
E
W
V
YDYTHEEWPFYKARP
T
---------
D
Y
------------------
P
------------------
T
-
Q
E
Q
Q
L
H
F
I
R
H
Y
L
-----
A
E
A
K
KG
E
-----------
T
-----------
L
S
Q
E
E
Q
R
K
L
E
E
D
L
L
V
E
V
S
R
Y
A
L
A
S
H
F
F
W
G
L
W
S
I
L
Q
---
A
S
M
--
S
-----
T
I--
E
F
G
Y
L
D
Y
A
Q
S
R
F
Q
------------------
23
HHSearch
40.77
21%
29
- C1 -
-
1NW1
-
CKA2_CAEEL
B:
[74-422]
--------------------------------------------------------------
E
H
L
R
I
S
R
I
K
G
G
M
S
N
M
L
F
L
C
R
--
L
S
EVYPPIRNE
P
----------
N
K
V
L
L
R
V
Y
F
N
P
E
T
-
E
--
S
H
L
V
A
E
S
V
I
F
-
T
L
L
S
E
R
H
L
G
P
K
L
Y
G
I
F
----
S
G
G
R
L
E
E
Y
I
P
S
-
R
P
-
L
S
C
-
H
E
--
I
S
L-
A
H
M
S
T
---
K
I
A
K
R
V
A
K
V
---
H
------
Q
L
E
V
P
I
W
K
--------------
E
P--
D
----
Y
----
L
--------
C
E
A
------------
L
Q
R
W
L
K
Q
L
T
G
T
---
V
-------------
D
--------
A
E
H
R
F
D
-------
L
P
---
E
ECGVSSVN
C
L
D
L
A
R
E
L
E
F
L
R
A
H
----------------
I
S
------
L
S
---
K
S
P
V
T
F
C
H
N
D
L
Q
E
G
N
--
I
L
--
L
P
K
---------
R
L
V
L
I
D
F
E
Y
A
S
Y
N
Y
R
A
F
D
F
A
N
H
F
I
E
-----------------
W
---------
T
I
DYDIDEAPF
Y
K
I
Q
TENFP
E
------------------
N
-
D
Q
M
L
E
-
F
F
L
N
Y
L
-----
R
E
Q
G
--------------
N
TRENE
L
Y
K
K
S
E
D
L
V
Q
-----------
E
T
L
P
F
V
P
V
S
H
F
F
W
G
V
W
G
L
L
Q
---
V
E
L
--
S
PVG--
F
---
G
F
A
--
D
Y
G
R
D
R
L
S
L
Y
F
K
H
K
Q
L
L
---------
52
Fugue
40.65
15%
4
- C1 -
-
2PPQ
-
KHSE_AGRFC
A:
[5-320]
------------------------------------------
T
D
I
T
E
D
E
L
R
N
F
L
T
-
Q
Y
----
D
V
G
S
L
T
S
Y
K
G
I
A
E
N
S
N
F
L
L
H
--
T
T
---------
K
----------
D
P
L
I
L
T
L
Y
E
K
K
-------
N
D
L
P
F
F
L
G
L
M
Q
H
L
A
A
K
G
L
S
C
P
L
P
L
P
R
K
DG
E
L
L
G
E
L
S
G
R
P
A
A
L
I
S
F
L
E
G
M
W
L
--
R
---
K
P
E
A
K
---
H
C
R
E
V
G
K
A
L
A
A
M
H
------
L
A
S
E
G
F
E
I
--------------
K
---
R
----
P
----
N
--------
A
L
S
------------
V
D
G
W
K
V
L
W
D
K
S
---
E
-------------
E
--------
R
------------
A
D
---
E
VE-------
K
G
L
R
E
E
I
R
P
E
I
D
Y
----------------
L
A
------
A
H
WPK
D
L
P
A
G
V
I
H
A
D
L
F
Q
D
N
--
V
F
--
F
L
G
D
------
E
-
L
S
G
L
I
D
F
Y
F
A
C
N
D
L
L
A
Y
D
V
S
I
C
L
N
A
WCFEKD-----------
G
---------
A
Y
------------------
N
------------------
V
-
T
K
G
K
A
-
L
L
E
G
Y
Q
S
V
R
P
L
S
E
A
E
--------------
L
-----------
E
A
L
P
-----------
L
L
S
R
G
S
A
L
R
F
F
L
T
R
L
Y
D
W
L
T
---
T
P
A
--
G
-----
A
---
L
V
V
--
K
K
D
P
L
E
Y
L
R
K
L
R
F
H
R
T
I
A
N
V
A
E
Y
GLA
22
HHSearch
40.45
21%
32
- C1 -
-
1NW1
-
CKA2_CAEEL
A:
[74-422]
--------------------------------------------------------------
E
H
L
R
I
S
R
I
K
G
G
M
S
N
M
L
F
L
C
R
--
L
S
EVYPPIRNE
P
----------
N
K
V
L
L
R
V
Y
F
N
P
E
T
-
E
--
S
H
L
V
A
E
S
V
I
F
-
T
L
L
S
E
R
H
L
G
P
K
L
Y
G
I
F
----
S
G
G
R
L
E
E
Y
I
P
S
-
R
P
-
L
S
C
-
H
E
--
I
S
L-
A
H
M
S
T
---
K
I
A
K
R
V
A
K
V
---
H
------
Q
L
E
V
P
I
W
K
--------------
E
P--
D
----
Y
----
L
--------
C
E
A
------------
L
Q
R
W
L
K
Q
L
T
G
T
---
V
-------------
D
--------
A
E
H
R
F
D
-------
L
P
---
E
ECGVSSVN
C
L
D
L
A
R
E
L
E
F
L
R
A
H
----------------
I
S
------
L
S
---
K
S
P
V
T
F
C
H
N
D
L
Q
E
G
N
--
I
L
--
L
P
K
---------
R
L
V
L
I
D
F
E
Y
A
S
Y
N
Y
R
A
F
D
F
A
N
H
F
I
E
-----------------
W
---------
T
I
DYDIDEAPF
Y
K
I
Q
TENFP
E
------------------
N
-
D
Q
M
L
E
-
F
F
L
N
Y
L
-----
R
E
Q
G
--------------
N
TRENE
L
Y
K
K
S
E
D
L
V
Q
-----------
E
T
L
P
F
V
P
V
S
H
F
F
W
G
V
W
G
L
L
Q
---
V
E
L
--
S
PVG--
F
---
G
F
A
--
D
Y
G
R
D
R
L
S
L
Y
F
K
H
K
Q
L
L
---------
28
HHSearch
40.16
20%
15
- C1 -
-
3C5I
3
?
D:
[18-359]
----------------------------------------------
K
K
I
C
L
E
K
V
P
E
W
N
HFTE
D
N
L
R
V
K
Q
I
L
--
L
T
N
Q
L
F
E
V
G
--
L
K
---------
E
E
T
A
N
N
Y
NSIR
T
R
V
L
F
R
I
Y
G
K
H
V
D
E
L
--
Y
N
T
I
S
E
F
E
V
Y
-
K
T
M
S
K
Y
K
I
A
P
Q
L
L
N
T
F
----
N
G
G
R
I
E
E
W
L
Y
G
D
-
P
-
L
R
I
-
D
D
L
K
N
---
P
T
I
L
I
---
G
I
A
N
V
L
G
K
F
---
H
------
T
L
S
R
K
R
H
L
--------------
P
EH-
W
DRTP
C
----
I
--------
F
K
M
------------
M
E
K
W
K
N
Q
L
F
K
Y
---
K
-------------
N
--------
I
EK----------
Y
N
C--
D
I
--------
H
K
Y
I
K
E
S
D
K
F
I
K
F
----------------
M
K
V
Y
S
KSD
N
L
---
A
N
T
I
V
F
C
H
N
D
L
Q
E
N
N
--
I
I
--
N
T
N
-------
K
-
C
L
R
L
I
D
F
E
Y
S
G
F
N
F
L
A
T
D
I
A
N
F
F
I
E
-----------------
T
---------
S
I
DYSVSSYPF
F
E
I
D
KKKYI
S
------------------
Y
-
E
N
R
K
L
-
F
I
T
A
Y
L
-----
S
N
Y
L
DKVV----------
P
T
P
K
L
I
D
-----
E
I
L
E
-----------
A
V
E
V
Q
A
L
G
A
H
L
L
W
G
F
W
S
I
I
R
---
G
Y
Q
--
T
KSYNE
F
---
D
F
F
--
L
Y
A
E
Q
R
L
K
M
Y
D
D
Q
K
E
Y
L
---------
32
HHSearch
40.06
19%
48
- C1 -
-
5FTG
10
CHKA_HUMAN
A:
[32-377]
----------------------------------------------------------------
F
H
I
S
V
I
R
G
G
L
S
N
M
L
F
Q
C
S
--
L
P
---------
D
TTATLGDEP-
R
K
V
L
L
R
L
Y
G
--------
E
A
M
V
L
E
S
V
M
F
-
A
I
L
A
E
R
S
L
G
P
K
L
Y
G
I
F
----
P
Q
G
R
L
E
Q
F
I
P
S
R
-
R
-
L
D
T
-
E
E
--
L
SL-
P
D
I
S
A
---
E
I
A
E
K
M
A
T
F
---
H
------
G
M
K
M
P
F
N
K
--------------
E
---
P
K---
W
----
L
--------
F
G
T
------------
M
E
K
Y
L
K
E
V
L
R
I
---
K
-------------
F
TE
E
S
R
I
K
K
L
------------
H
K
---
L
L
S-------
Y
N
L
P
L
E
L
E
N
L
R
S
L
----------------
L
E
------
S
T
---
P
S
P
V
V
F
C
H
N
D
C
Q
E
G
N
--
I
L
--
L
L
E
G
RENSEK
Q
-
K
L
M
L
I
D
F
E
Y
S
S
Y
N
Y
R
G
F
D
I
G
N
H
F
C
E
-----------------
W
---------
M
Y
DYSYEKYPF
F
R
A
N
IRKYP
T
------------------
K
-
K
Q
Q
L
H
-
F
I
S
S
Y
L
-----
P
A
F
Q
NDFENLS
T
E
E
K
S
I
I
K
E
----------
E
M
L
L
-----------
E
V
N
R
F
A
L
A
S
H
F
L
W
G
L
W
S
I
V
Q
---
A
K
I
--
S
-----
S
IEF
G
Y
M
--
D
Y
A
Q
A
R
F
D
A
Y
F
H
Q
K
R
K
L
G
--------
7
PsiBlast_PDB
38.77
26%
-116
- C2 -
-
3WUB
-
XYNA_STRSQ
A:
[176-236]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
P
K
S
D
A
V
---
Y
------
E
M
V
K
S
F
K
A
--------------
Q
---
G
----
I
----
P
--------
I
D
G
------------
V
G
M
Q
A
H
L
I
A
G
Q
---
V
-------------
P
--------
A
------------
S
L
---
Q
---------
E
N
I
R
--------
R
----------------
F
A
------
D
L
---
G
V
D
V
A
L
T
E
L
D
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------