@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : spr1155: (2018-01-06 )
MSENQQALNHVVSMEDLTVDQVMKLIKRGIEFKNGAQIPYEDHPIVSNLFFEDSTRTHKSFEVAEIKLGLERLDFDVKTSSVNKGETLYDTILTLSALGVDVCVIRHPEVDYYRELIASPTITTSIINGGDGSGQHPSQSLLDLMTIYEEFGHFEGLKVAIAGDLDHSRVAKSNMQILKRLGSELFFAGPEEWRSQEFADYGKFVTIDEIIDQVDVMMFLRVQHERHDSGAVFSKEDYHAQHGLTQERYDRLKETAILMHPAPINRDVEIADHLVEAPKSRIVQQMTNGVFVRMAILESVLASRNAN
Atome Classification :
(69 SA)
.........10........20........30........40........50........60........70....-.--...--80........90........100.......110.-.......120........130.......140.......150.......160.......170.......180........190.--..-----...---------.--200------.....----....210.......220.......230.--......240.......250.......260.......270.......280.......290.......300.....
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MS
E
N
Q
Q
A
L
N
H
V
V
S
M
E
DL
T
V
D
Q
V
M
K
L
I
K
RGIEFKNGAQIPYEDHP
I
V
S
N
L
F
FEDSTRTHKS
F
E
V
A
E
I
K
L
G
L
E
RL
D
F
-
D
--
V
KT--SSVNKG
E
T
L
Y
D
T
I
L
T
L
S
AL
G
V
D
V
C
V
I
RHP
E
V
-
D
Y
-
Y
R
E
L
IASP
T
-
I
T
T
S
I
INGGDGSGQH
P
S
Q
S
L
L
D
L
M
T
I
Y
E
E
FGHFE
G
L
K
V
A
I
AGDL
D
H
S
R
V
A
K
S
N
M
Q
I
L
K
R
L-G
S
E
L
F
FA
G
P
E
E
W
--
R
S
-----
Q
E
F
---------
A
--D--------YG
K
F
V
----
T
I
D
E
I
I
D
Q
V
D
V
M
M
F
L
R
V
Q
H
ERHDSGAVF--SKED
Y
H
A
QHGL
T
Q
E
R
Y
D
R
L
K
E
T
A
I
L
MHPAPINR
D
V
E
I
A
D
H
L
V
EA
P
K
S
R
I
V
Q
Q
M
TN
G
V
F
V
R
M
A
I
L
E
S
V
L
A
SRNAN
27
PsiBlast_CBE
99.13
52%
-101
- C7 -
-
3R7F
3
PYRB_BACSU
B:
[1-291]
-------
M
K
H
L
T
T
M
S
E
L
S
T
E
E
I
K
D
L
L
Q
T
A
Q
E
L
K
S
G
K
T
D
N
Q
L
T
G
K
F
A
A
N
L
F
F
E
P
S
T
R
T
R
F
S
F
E
V
A
E
K
K
L
G
M
N
V
L
N
L
-
D
--
G
T
S
--
T
S
V
Q
K
G
E
T
L
Y
D
T
I
R
T
L
E
S
I
G
V
D
V
C
V
I
R
H
S
E
D
-
E
Y
-
Y
E
E
L
V
S
Q
V
N
-
I
--
P
I
L
N
A
G
D
G
C
G
Q
H
P
T
Q
S
L
L
D
L
M
T
I
Y
E
E
F
N
T
F
K
G
L
T
V
S
I
H
G
D
I
K
H
S
R
V
A
R
S
N
A
E
V
L
T
R
L
-
G
A
R
V
L
F
S
G
P
S
E
W
--
Q
D
-----
E
E
----------
N
--
T
--------
F
G
T
Y
V
----
S
M
D
E
A
V
E
S
S
D
V
V
M
L
L
R
I
Q
N
E
R
H
Q
S
A
V
----
S
Q
E
G
Y
L
N
K
Y
G
L
T
V
E
R
A
E
R
M
K
R
H
A
I
I
M
H
P
A
P
V
N
R
G
V
E
I
D
D
S
L
V
E
S
E
K
S
R
I
F
K
Q
M
K
N
G
V
F
I
R
M
A
V
I
Q
R
A
L
Q
T
----
3
PsiBlast_PDB
98.07
52%
-95
- C7 -
-
3R7F
1
PYRB_BACSU
A:
[1-291]
-------
M
K
H
L
T
T
M
S
E
L
S
T
E
E
I
K
D
L
L
Q
T
A
Q
E
L
K
S
G
K
T
D
N
Q
L
T
G
K
F
A
A
N
L
F
F
E
P
S
T
R
T
R
F
S
F
E
V
A
E
K
K
L
G
M
N
V
L
N
L
-
D
--
G
T
S
--
T
S
V
Q
K
G
E
T
L
Y
D
T
I
R
T
L
E
S
I
G
V
D
V
C
V
I
R
H
S
E
D
-
E
Y
-
Y
E
E
L
V
S
Q
V
N
-
I
--
P
I
L
N
A
G
D
G
C
G
Q
H
P
T
Q
S
L
L
D
L
M
T
I
Y
E
E
F
N
T
F
K
G
L
T
V
S
I
H
G
D
I
K
H
S
R
V
A
R
S
N
A
E
V
L
T
R
L
-
G
A
R
V
L
F
S
G
P
S
E
W
--
Q
D
-----
E
E
----------
N
--
T
--------
F
G
T
Y
V
----
S
M
D
E
A
V
E
S
S
D
V
V
M
L
L
R
I
Q
N
E
R
H
Q
S
A
V
----
S
Q
E
G
Y
L
N
K
Y
G
L
T
V
E
R
A
E
R
M
K
R
H
A
I
I
M
H
P
A
P
V
N
R
G
V
E
I
D
D
S
L
V
E
S
E
K
S
R
I
F
K
Q
M
K
N
G
V
F
I
R
M
A
V
I
Q
R
A
L
Q
T
----
26
PsiBlast_CBE
96.78
52%
-98
- C7 -
-
3R7F
1
PYRB_BACSU
C:
[1-291]
-------
M
K
H
L
T
T
M
S
E
L
S
T
E
E
I
K
D
L
L
Q
T
A
Q
E
L
K
S
G
K
T
D
N
Q
L
T
G
K
F
A
A
N
L
F
F
E
P
S
T
R
T
R
F
S
F
E
V
A
E
K
K
L
G
M
N
V
L
N
L
-
D
--
G
T
S
--
T
S
V
Q
K
G
E
T
L
Y
D
T
I
R
T
L
E
S
I
G
V
D
V
C
V
I
R
H
S
E
D
-
E
Y
-
Y
E
E
L
V
S
Q
V
N
-
I
--
P
I
L
N
A
G
D
G
C
G
Q
H
P
T
Q
S
L
L
D
L
M
T
I
Y
E
E
F
N
T
F
K
G
L
T
V
S
I
H
G
D
I
K
H
S
R
V
A
R
S
N
A
E
V
L
T
R
L
-
G
A
R
V
L
F
S
G
P
S
E
W
--
Q
D
-----
E
E
----------
N
--
T
--------
F
G
T
Y
V
----
S
M
D
E
A
V
E
S
S
D
V
V
M
L
L
R
I
Q
N
E
R
H
Q
S
A
V
----
S
Q
E
G
Y
L
N
K
Y
G
L
T
V
E
R
A
E
R
M
K
R
H
A
I
I
M
H
P
A
P
V
N
R
G
V
E
I
D
D
S
L
V
E
S
E
K
S
R
I
F
K
Q
M
K
N
G
V
F
I
R
M
A
V
I
Q
R
A
L
Q
T
----
2
PsiBlast_PDB
96.54
52%
-98
- C7 -
-
3R7D
-
PYRB_BACSU
A:
[1-291]
-------
M
K
H
L
T
T
M
S
E
L
S
T
E
E
I
K
D
L
L
Q
T
A
Q
E
L
K
S
G
K
T
D
N
Q
L
T
G
K
F
A
A
N
L
F
F
E
P
S
T
R
T
R
F
S
F
E
V
A
E
K
K
L
G
M
N
V
L
N
L
-
D
--
G
T
S
--
T
S
V
Q
K
G
E
T
L
Y
D
T
I
R
T
L
E
S
I
G
V
D
V
C
V
I
R
H
S
E
D
-
E
Y
-
Y
E
E
L
V
S
Q
V
N
-
I
--
P
I
L
N
A
G
D
G
C
G
Q
H
P
T
Q
S
L
L
D
L
M
T
I
Y
E
E
F
N
T
F
K
G
L
T
V
S
I
H
G
D
I
K
H
S
R
V
A
R
S
N
A
E
V
L
T
R
L
-
G
A
R
V
L
F
S
G
P
S
E
W
--
Q
D
-----
E
E
----------
N
--
T
--------
F
G
T
Y
V
----
S
M
D
E
A
V
E
S
S
D
V
V
M
L
L
R
I
Q
N
E
R
H
Q
S
A
V
----
S
Q
E
G
Y
L
N
K
Y
G
L
T
V
E
R
A
E
R
M
K
R
H
A
I
I
M
H
P
A
P
V
N
R
G
V
E
I
D
D
S
L
V
E
S
E
K
S
R
I
F
K
Q
M
K
N
G
V
F
I
R
M
A
V
I
Q
R
A
L
Q
T
----
126
HHSearch
96.00
51%
-91
- C7 -
-
3R7F
1
PYRB_BACSU
A:
[1-291]
-------
M
K
H
L
T
T
M
S
E
L
S
T
E
E
I
K
D
L
L
Q
T
A
Q
E
L
K
S
G
K
T
D
N
Q
L
T
G
K
F
A
A
N
L
F
F
E
P
S
T
R
T
R
F
S
F
E
V
A
E
K
K
L
G
M
N
V
L
N
L
-
D
--
G
T
S
--
T
S
V
Q
K
G
E
T
L
Y
D
T
I
R
T
L
E
S
I
G
V
D
V
C
V
I
R
H
S
E
D
-
E
---
Y
Y
E
E
L
V
S
Q
-
V
N
I
P
I
L
N
A
G
D
G
C
G
Q
H
P
T
Q
S
L
L
D
L
M
T
I
Y
E
E
F
N
T
F
K
G
L
T
V
S
I
H
G
D
I
K
H
S
R
V
A
R
S
N
A
E
V
L
T
R
L
-
G
A
R
V
L
F
S
G
P
S
E
W
--
Q
D
-----
E
E
N
------------
T
--------
F
G
T
Y
V
----
S
M
D
E
A
V
E
S
S
D
V
V
M
L
L
R
I
Q
N
E
R
H
Q
S
A
--
V
--
S
Q
E
G
Y
L
N
K
Y
G
L
T
V
E
R
A
E
R
M
K
R
H
A
I
I
M
H
P
A
P
V
N
R
G
V
E
I
D
D
S
L
V
E
S
E
K
S
R
I
F
K
Q
M
K
N
G
V
F
I
R
M
A
V
I
Q
R
A
L
Q
T
----
24
PsiBlast_CBE
95.94
52%
-89
- C7 -
-
3R7L
2
PYRB_BACSU
C:
[1-290]
-------
M
K
H
L
T
T
M
S
E
L
S
T
E
E
I
K
D
L
L
Q
T
A
Q
E
L
K
S
G
K
T
D
N
Q
L
T
G
K
F
A
A
N
L
F
F
E
P
S
T
R
T
R
F
S
F
E
V
A
E
K
K
L
G
M
N
V
L
N
L
-
D
--
G
T
S
--
T
S
V
Q
K
G
E
T
L
Y
D
T
I
R
T
L
E
S
I
G
V
D
V
C
V
I
R
H
S
E
D
-
E
Y
-
Y
E
E
L
V
S
Q
V
N
-
I
--
P
I
L
N
A
G
D
G
C
G
Q
H
P
T
Q
S
L
L
D
L
M
T
I
Y
E
E
F
N
T
F
K
G
L
T
V
S
I
H
G
D
I
K
H
S
R
V
A
R
S
N
A
E
V
L
T
R
L
-
G
A
R
V
L
F
S
G
P
S
E
W
--
Q
D
-----
E
E
----------
N
--
T
--------
F
G
T
Y
V
----
S
M
D
E
A
V
E
S
S
D
V
V
M
L
L
R
I
Q
N
E
R
H
Q
S
A
V
----
S
Q
E
G
Y
L
N
K
Y
G
L
T
V
E
R
A
E
R
M
K
R
H
A
I
I
M
H
P
A
P
V
N
R
G
V
E
I
D
D
S
L
V
E
S
E
K
S
R
I
F
K
Q
M
K
N
G
V
F
I
R
M
A
V
I
Q
R
A
L
Q
-----
25
PsiBlast_CBE
95.14
52%
-91
- C7 -
-
3R7L
2
PYRB_BACSU
B:
[1-290]
-------
M
K
H
L
T
T
M
S
E
L
S
T
E
E
I
K
D
L
L
Q
T
A
Q
E
L
K
S
G
K
T
D
N
Q
L
T
G
K
F
A
A
N
L
F
F
E
P
S
T
R
T
R
F
S
F
E
V
A
E
K
K
L
G
M
N
V
L
N
L
-
D
--
G
T
S
--
T
S
V
Q
K
G
E
T
L
Y
D
T
I
R
T
L
E
S
I
G
V
D
V
C
V
I
R
H
S
E
D
-
E
Y
-
Y
E
E
L
V
S
Q
V
N
-
I
--
P
I
L
N
A
G
D
G
C
G
Q
H
P
T
Q
S
L
L
D
L
M
T
I
Y
E
E
F
N
T
F
K
G
L
T
V
S
I
H
G
D
I
K
H
S
R
V
A
R
S
N
A
E
V
L
T
R
L
-
G
A
R
V
L
F
S
G
P
S
E
W
--
Q
D
-----
E
E
----------
N
--
T
--------
F
G
T
Y
V
----
S
M
D
E
A
V
E
S
S
D
V
V
M
L
L
R
I
Q
N
E
R
H
Q
S
A
V
----
S
Q
E
G
Y
L
N
K
Y
G
L
T
V
E
R
A
E
R
M
K
R
H
A
I
I
M
H
P
A
P
V
N
R
G
V
E
I
D
D
S
L
V
E
S
E
K
S
R
I
F
K
Q
M
K
N
G
V
F
I
R
M
A
V
I
Q
R
A
L
Q
-----
4
PsiBlast_PDB
94.98
52%
-90
- C7 -
-
3R7L
2
PYRB_BACSU
A:
[1-290]
-------
M
K
H
L
T
T
M
S
E
L
S
T
E
E
I
K
D
L
L
Q
T
A
Q
E
L
K
S
G
K
T
D
N
Q
L
T
G
K
F
A
A
N
L
F
F
E
P
S
T
R
T
R
F
S
F
E
V
A
E
K
K
L
G
M
N
V
L
N
L
-
D
--
G
T
S
--
T
S
V
Q
K
G
E
T
L
Y
D
T
I
R
T
L
E
S
I
G
V
D
V
C
V
I
R
H
S
E
D
-
E
Y
-
Y
E
E
L
V
S
Q
V
N
-
I
--
P
I
L
N
A
G
D
G
C
G
Q
H
P
T
Q
S
L
L
D
L
M
T
I
Y
E
E
F
N
T
F
K
G
L
T
V
S
I
H
G
D
I
K
H
S
R
V
A
R
S
N
A
E
V
L
T
R
L
-
G
A
R
V
L
F
S
G
P
S
E
W
--
Q
D
-----
E
E
----------
N
--
T
--------
F
G
T
Y
V
----
S
M
D
E
A
V
E
S
S
D
V
V
M
L
L
R
I
Q
N
E
R
H
Q
S
A
V
----
S
Q
E
G
Y
L
N
K
Y
G
L
T
V
E
R
A
E
R
M
K
R
H
A
I
I
M
H
P
A
P
V
N
R
G
V
E
I
D
D
S
L
V
E
S
E
K
S
R
I
F
K
Q
M
K
N
G
V
F
I
R
M
A
V
I
Q
R
A
L
Q
-----
21
PsiBlast_CBE
94.88
52%
-89
- C7 -
-
3R7L
2
PYRB_BACSU
F:
[1-290]
-------
M
K
H
L
T
T
M
S
E
L
S
T
E
E
I
K
D
L
L
Q
T
A
Q
E
L
K
S
G
K
T
D
N
Q
L
T
G
K
F
A
A
N
L
F
F
E
P
S
T
R
T
R
F
S
F
E
V
A
E
K
K
L
G
M
N
V
L
N
L
-
D
--
G
T
S
--
T
S
V
Q
K
G
E
T
L
Y
D
T
I
R
T
L
E
S
I
G
V
D
V
C
V
I
R
H
S
E
D
-
E
Y
-
Y
E
E
L
V
S
Q
V
N
-
I
--
P
I
L
N
A
G
D
G
C
G
Q
H
P
T
Q
S
L
L
D
L
M
T
I
Y
E
E
F
N
T
F
K
G
L
T
V
S
I
H
G
D
I
K
H
S
R
V
A
R
S
N
A
E
V
L
T
R
L
-
G
A
R
V
L
F
S
G
P
S
E
W
--
Q
D
-----
E
E
----------
N
--
T
--------
F
G
T
Y
V
----
S
M
D
E
A
V
E
S
S
D
V
V
M
L
L
R
I
Q
N
E
R
H
Q
S
A
V
----
S
Q
E
G
Y
L
N
K
Y
G
L
T
V
E
R
A
E
R
M
K
R
H
A
I
I
M
H
P
A
P
V
N
R
G
V
E
I
D
D
S
L
V
E
S
E
K
S
R
I
F
K
Q
M
K
N
G
V
F
I
R
M
A
V
I
Q
R
A
L
Q
-----
22
PsiBlast_CBE
94.87
52%
-89
- C7 -
-
3R7L
2
PYRB_BACSU
E:
[1-290]
-------
M
K
H
L
T
T
M
S
E
L
S
T
E
E
I
K
D
L
L
Q
T
A
Q
E
L
K
S
G
K
T
D
N
Q
L
T
G
K
F
A
A
N
L
F
F
E
P
S
T
R
T
R
F
S
F
E
V
A
E
K
K
L
G
M
N
V
L
N
L
-
D
--
G
T
S
--
T
S
V
Q
K
G
E
T
L
Y
D
T
I
R
T
L
E
S
I
G
V
D
V
C
V
I
R
H
S
E
D
-
E
Y
-
Y
E
E
L
V
S
Q
V
N
-
I
--
P
I
L
N
A
G
D
G
C
G
Q
H
P
T
Q
S
L
L
D
L
M
T
I
Y
E
E
F
N
T
F
K
G
L
T
V
S
I
H
G
D
I
K
H
S
R
V
A
R
S
N
A
E
V
L
T
R
L
-
G
A
R
V
L
F
S
G
P
S
E
W
--
Q
D
-----
E
E
----------
N
--
T
--------
F
G
T
Y
V
----
S
M
D
E
A
V
E
S
S
D
V
V
M
L
L
R
I
Q
N
E
R
H
Q
S
A
V
----
S
Q
E
G
Y
L
N
K
Y
G
L
T
V
E
R
A
E
R
M
K
R
H
A
I
I
M
H
P
A
P
V
N
R
G
V
E
I
D
D
S
L
V
E
S
E
K
S
R
I
F
K
Q
M
K
N
G
V
F
I
R
M
A
V
I
Q
R
A
L
Q
-----
23
PsiBlast_CBE
94.64
52%
-90
- C7 -
-
3R7L
2
PYRB_BACSU
D:
[1-290]
-------
M
K
H
L
T
T
M
S
E
L
S
T
E
E
I
K
D
L
L
Q
T
A
Q
E
L
K
S
G
K
T
D
N
Q
L
T
G
K
F
A
A
N
L
F
F
E
P
S
T
R
T
R
F
S
F
E
V
A
E
K
K
L
G
M
N
V
L
N
L
-
D
--
G
T
S
--
T
S
V
Q
K
G
E
T
L
Y
D
T
I
R
T
L
E
S
I
G
V
D
V
C
V
I
R
H
S
E
D
-
E
Y
-
Y
E
E
L
V
S
Q
V
N
-
I
--
P
I
L
N
A
G
D
G
C
G
Q
H
P
T
Q
S
L
L
D
L
M
T
I
Y
E
E
F
N
T
F
K
G
L
T
V
S
I
H
G
D
I
K
H
S
R
V
A
R
S
N
A
E
V
L
T
R
L
-
G
A
R
V
L
F
S
G
P
S
E
W
--
Q
D
-----
E
E
----------
N
--
T
--------
F
G
T
Y
V
----
S
M
D
E
A
V
E
S
S
D
V
V
M
L
L
R
I
Q
N
E
R
H
Q
S
A
V
----
S
Q
E
G
Y
L
N
K
Y
G
L
T
V
E
R
A
E
R
M
K
R
H
A
I
I
M
H
P
A
P
V
N
R
G
V
E
I
D
D
S
L
V
E
S
E
K
S
R
I
F
K
Q
M
K
N
G
V
F
I
R
M
A
V
I
Q
R
A
L
Q
-----
1
PsiBlast_PDB
84.14
52%
-
- C7 -
-
2AT2
-
PYRB_BACSU
A:
[1-291]
-------
M
K
H
L
T
T
M
S
E
L
S
T
E
E
I
K
D
L
L
Q
T
A
Q
E
L
K
S
G
K
T
D
N
Q
L
T
G
K
F
A
A
N
L
F
F
E
P
S
T
R
T
R
F
S
F
E
V
A
E
K
K
L
G
M
N
V
L
N
L
-
D
--
G
T
S
--
T
S
V
Q
K
G
E
T
L
Y
D
T
I
R
T
L
E
S
I
G
V
D
V
C
V
I
R
H
S
E
D
-
E
Y
-
Y
E
E
L
V
S
Q
V
N
-
I
--
P
I
L
N
A
G
D
G
C
G
Q
H
P
T
Q
S
L
L
D
L
M
T
I
Y
E
E
F
N
T
F
K
G
L
T
V
S
I
H
G
D
I
K
H
S
R
V
A
R
S
N
A
E
V
L
T
R
L
-
G
A
R
V
L
F
S
G
P
S
E
W
--
Q
D
-----
E
E
----------
N
--
T
--------
F
G
T
Y
V
----
S
M
D
E
A
V
E
S
S
D
V
V
M
L
L
R
I
Q
N
E
R
H
Q
S
A
V
----
S
Q
E
G
Y
L
N
K
Y
G
L
T
V
E
R
A
E
R
M
K
R
H
A
I
I
M
H
P
A
P
V
N
R
G
V
E
I
D
D
S
L
V
E
S
E
K
S
R
I
F
K
Q
M
K
N
G
V
F
I
R
M
A
V
I
Q
C
A
L
Q
T
----
125
HHSearch
83.41
51%
-
- C7 -
-
2AT2
-
PYRB_BACSU
C:
[1-293]
-------
M
K
H
L
T
T
M
S
E
L
S
T
E
E
I
K
D
L
L
Q
T
A
Q
E
L
K
S
G
K
T
D
N
Q
L
T
G
K
F
A
A
N
L
F
F
E
P
S
T
R
T
R
F
S
F
E
V
A
E
K
K
L
G
M
N
V
L
N
L
-
D
--
G
T
S
--
T
S
V
Q
K
G
E
T
L
Y
D
T
I
R
T
L
E
S
I
G
V
D
V
C
V
I
R
H
S
E
D
-
E
---
Y
Y
E
E
L
V
S
Q
-
V
N
I
P
I
L
N
A
G
D
G
C
G
Q
H
P
T
Q
S
L
L
D
L
M
T
I
Y
E
E
F
N
T
F
K
G
L
T
V
S
I
H
G
D
I
K
H
S
R
V
A
R
S
N
A
E
V
L
T
R
L
-
G
A
R
V
L
F
S
G
P
S
E
W
--
Q
D
-----
E
E
N
------------
T
--------
F
G
T
Y
V
----
S
M
D
E
A
V
E
S
S
D
V
V
M
L
L
R
I
Q
N
E
R
H
Q
S
A
--
V
--
S
Q
E
G
Y
L
N
K
Y
G
L
T
V
E
R
A
E
R
M
K
R
H
A
I
I
M
H
P
A
P
V
N
R
G
V
E
I
D
D
S
L
V
E
S
E
K
S
R
I
F
K
Q
M
K
N
G
V
F
I
R
M
A
V
I
Q
C
A
L
Q
T
N
V
--
133
HHSearch
71.90
37%
-21
- C7 -
-
3D6N
-
PYRB_AQUAE
B:
[1-290]
-------
M
R
S
L
I
S
S
L
D
L
T
R
E
E
V
E
E
I
L
K
Y
A
K
E
F
K
E
G
K
-
E
E
T
I
-
K
A
S
A
V
L
F
F
S
E
P
S
T
R
T
R
L
S
F
E
K
A
A
R
E
L
G
I
E
T
Y
L
V
-
S
--
G
S
E
--
S
S
T
V
K
G
E
S
F
F
D
T
L
K
T
F
E
G
L
G
F
D
Y
V
V
F
R
V
P
F
V
F
F
---
P
Y
K
E
I
V
K
S
-
L
N
L
R
L
V
N
A
G
D
G
T
H
Q
H
P
S
Q
G
L
I
D
F
F
T
I
K
E
H
F
G
E
V
K
D
L
R
V
L
Y
V
G
D
I
K
H
S
R
V
F
R
S
G
A
P
L
L
N
M
F
-
G
A
K
I
G
V
C
G
P
K
T
L
--
I
P
-----
R
D
V
---------
E
VF
K
--------
V
D
V
F
D
----
D
V
D
K
G
I
D
W
A
D
V
V
I
W
L
R
L
Q
K
E
R
Q
K
E
N
Y
I
P
--
S
E
S
S
Y
F
K
Q
F
G
L
T
K
E
R
F
E
K
---
V
K
L
Y
M
H
P
G
P
V
N
R
N
V
D
I
D
H
E
L
V
Y
T
E
K
S
L
I
Q
E
Q
V
K
N
G
I
P
V
R
K
A
I
Y
K
F
L
W
------
5
PsiBlast_PDB
70.88
37%
-24
- C7 -
-
4BJH
10
PYRB_AQUAE
B:
[32-316]
-------
M
R
S
L
I
S
S
L
D
L
T
R
E
E
V
E
E
I
L
K
Y
A
K
E
F
K
E
G
K
E
E
T
I
K
A
S
A
V
L
--
F
F
S
E
P
S
T
R
T
R
L
S
F
E
K
A
A
R
E
L
G
I
E
T
Y
L
V
-
S
--
G
S
E
--
S
S
T
V
K
G
E
S
F
F
D
T
L
K
T
F
E
G
L
G
F
D
Y
V
V
F
R
V
P
F
V
-
F
F
P
Y
K
E
I
V
K
S
---
L
N
L
R
L
V
N
A
G
D
G
T
H
Q
H
P
S
Q
G
L
I
D
F
F
T
I
K
E
H
F
G
E
V
K
D
L
R
V
L
Y
V
G
D
I
K
H
S
R
V
F
R
S
G
A
P
L
L
N
M
F
-
G
A
K
I
G
V
C
G
P
K
T
L
IP
R
D
-----
V
E
V
---------
F
--
K
--------
V
D
V
F
D
----
D
V
D
K
G
I
D
W
A
D
V
V
I
W
L
R
L
Q
K
E
R
Q
K
E
N
Y
I
P
--
S
E
S
S
Y
F
K
Q
F
G
L
T
K
E
R
F
E
K
V
K
---
L
Y
M
H
P
G
P
V
N
R
N
V
D
I
D
H
E
L
V
Y
T
E
K
S
L
I
Q
E
Q
V
K
N
G
I
P
V
R
K
A
I
-----------
137
HHSearch
70.56
36%
-20
- C7 -
-
4BJH
10
PYRB_AQUAE
B:
[32-321]
-------
M
R
S
L
I
S
S
L
D
L
T
R
E
E
V
E
E
I
L
K
Y
A
K
E
F
K
E
G
K
-
E
E
T
I
-
K
A
S
A
V
L
F
F
S
E
P
S
T
R
T
R
L
S
F
E
K
A
A
R
E
L
G
I
E
T
Y
L
V
-
S
--
G
S
E
--
S
S
T
V
K
G
E
S
F
F
D
T
L
K
T
F
E
G
L
G
F
D
Y
V
V
F
R
V
P
F
V
F
F
---
P
Y
K
E
I
V
K
S
-
L
N
L
R
L
V
N
A
G
D
G
T
H
Q
H
P
S
Q
G
L
I
D
F
F
T
I
K
E
H
F
G
E
V
K
D
L
R
V
L
Y
V
G
D
I
K
H
S
R
V
F
R
S
G
A
P
L
L
N
M
F
-
G
A
K
I
G
V
C
G
P
K
T
L
--
I
P
-----
R
D
V
---------
E
VF
K
--------
V
D
V
F
D
----
D
V
D
K
G
I
D
W
A
D
V
V
I
W
L
R
L
Q
K
E
R
Q
K
E
N
Y
I
P
--
S
E
S
S
Y
F
K
Q
F
G
L
T
K
E
R
F
E
K
---
V
K
L
Y
M
H
P
G
P
V
N
R
N
V
D
I
D
H
E
L
V
Y
T
E
K
S
L
I
Q
E
Q
V
K
N
G
I
P
V
R
K
A
I
Y
K
F
L
W
------
138
HHSearch
69.69
35%
-5
- C7 -
-
4E2F
-
PYRB_ECOLI
A:
[2-307]
---
N
P
L
Y
Q
K
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
L
K
A
N
P
Q
P
E
L
L
K
H
K
V
I
A
S
C
F
F
E
A
S
T
R
T
R
L
S
F
E
T
S
M
H
R
L
G
A
S
V
V
G
F
-
S
--
D
S
A
NT
S
L
G
K
K
G
E
T
L
A
D
T
I
S
V
I
S
T
Y
-
V
D
A
I
V
M
R
H
P
Q
E
-
G
---
A
A
R
L
A
T
E
F
S
G
N
V
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
Q
E
T
Q
G
R
L
D
N
L
H
V
A
M
V
G
D
L
E
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
D
G
N
R
F
Y
F
I
A
P
D
A
L
A-
M
P
-----
Q
Y
I
---------
L
--
D
M
L
D
E
K
G
I
A
W
S
L
H
S
----
S
I
E
E
V
M
A
E
V
D
I
L
Y
M
T
R
V
Q
K
E
R
L
D
P
---
S
--
K
Y
A
N
V
K
A
Q
F
V
L
R
A
S
D
L
H
N
A
K
A
N
M
K
V
L
H
P
L
P
R
V
D
--
E
I
A
T
D
V
D
K
T
P
H
A
W
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
A
L
V
L
N
R
D
---
119
PsiBlast_CBE
69.12
33%
-11
- C7 -
-
1TUG
1
PYRB_ECOLI
C:
[8-304]
---------
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
L
K
A
N
P
Q
P
E
L
L
K
H
K
V
I
A
S
C
F
F
A
A
S
T
R
T
R
L
S
F
E
T
S
M
H
R
L
G
A
S
V
V
G
F
-
S
DS
A
N
T
--
S
L
G
K
K
G
E
T
L
A
D
T
I
S
V
I
S
T
Y
-
V
D
A
I
V
M
R
H
P
Q
E
-
G
A
-
A
R
-
L
A
T
E
F
S
-
G
N
V
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
Q
E
T
Q
G
R
L
D
N
L
H
V
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
D
G
N
R
F
Y
F
I
A
P
D
A
L
--
A
M
-----
P
Q
Y
ILDMLDEKG
I
--
A
--------
W
S
L
H
S
----
S
I
E
E
V
M
A
E
V
D
I
L
Y
M
T
R
V
Q
K
E
R
L
D
P
S
-----
E
Y
A
N
V
K
A
Q
F
V
L
R
A
S
D
L
H
N
A
K
A
N
M
K
V
L
H
P
L
P
--
R
V
D
E
I
A
T
D
V
D
K
T
P
H
A
W
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
A
L
V
L
------
108
PsiBlast_CBE
68.85
33%
-1
- C7 -
-
3AT1
1
PYRB_ECOLI
C:
[8-304]
---------
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
L
K
A
N
P
Q
P
E
L
L
K
H
K
V
I
A
S
C
F
F
E
A
S
T
R
T
R
L
S
F
Q
T
S
M
H
R
L
G
A
S
V
V
G
F
-
S
DS
A
N
T
--
S
L
G
K
K
G
E
T
L
A
D
T
I
S
V
I
S
T
Y
-
V
D
A
I
V
M
R
H
P
Q
E
-
G
A
-
A
R
-
L
A
T
E
F
S
-
G
N
V
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
Q
Q
T
E
G
R
L
D
N
L
H
V
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
D
G
N
R
F
Y
F
I
A
P
D
A
L
--
A
M
-----
P
E
Y
ILDMLDEKG
I
--
A
--------
W
S
L
H
S
----
S
I
E
E
V
M
A
E
V
D
I
L
Y
M
T
R
V
Q
K
E
R
L
D
P
S
-----
E
Y
A
N
V
K
A
Q
F
V
L
R
A
S
D
L
H
N
A
K
A
N
M
K
V
L
H
P
L
P
--
R
V
D
E
I
A
T
D
V
D
K
T
P
H
A
W
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
A
L
V
L
------
114
PsiBlast_CBE
68.81
33%
1
- C7 -
-
1AT1
1
PYRB_ECOLI
C:
[8-304]
---------
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
L
K
A
N
P
Q
P
E
L
L
K
H
K
V
I
A
S
C
F
F
E
A
S
T
R
T
R
L
S
F
Q
T
S
M
H
R
L
G
A
S
V
V
G
F
-
S
DS
A
N
T
--
S
L
G
K
K
G
E
T
L
A
D
T
I
S
V
I
S
T
Y
-
V
D
A
I
V
M
R
H
P
Q
E
-
G
A
-
A
R
-
L
A
T
E
F
S
-
G
N
V
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
Q
Q
T
E
G
R
L
D
N
L
H
V
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
D
G
N
R
F
Y
F
I
A
P
D
A
L
--
A
M
-----
P
E
Y
ILDMLDEKG
I
--
A
--------
W
S
L
H
S
----
S
I
E
E
V
M
A
E
V
D
I
L
Y
M
T
R
V
Q
K
E
R
L
D
P
S
-----
E
Y
A
N
V
K
A
Q
F
V
L
R
A
S
D
L
H
N
A
K
A
N
M
K
V
L
H
P
L
P
--
R
V
D
E
I
A
T
D
V
D
K
T
P
H
A
W
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
A
L
V
L
------
71
PsiBlast_CBE
68.58
33%
-4
- C7 -
-
2FZG
1
PYRB_ECOLI
C:
[8-304]
---------
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
L
K
A
N
P
Q
P
E
L
L
K
H
K
V
I
A
S
C
F
F
E
A
S
T
R
T
R
L
S
F
E
T
S
M
H
R
L
G
A
S
V
V
G
F
-
S
DS
A
N
T
--
S
L
G
K
K
G
E
T
L
A
D
T
I
S
V
I
S
T
Y
-
V
D
A
I
V
M
R
H
P
Q
E
-
G
A
-
A
R
-
L
A
T
E
F
S
-
G
N
V
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
Q
E
T
Q
G
R
L
D
N
L
H
V
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
D
G
N
R
F
Y
F
I
A
P
D
A
L
--
A
M
-----
P
Q
Y
ILDMLDEKG
I
--
A
--------
W
S
L
H
S
----
S
I
E
E
V
M
A
E
V
D
I
L
Y
M
T
R
V
Q
K
E
R
L
D
P
S
-----
E
Y
A
N
V
K
A
Q
F
V
L
R
A
S
D
L
H
N
A
K
A
N
M
K
V
L
H
P
L
P
--
R
V
D
E
I
A
T
D
V
D
K
T
P
H
A
W
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
A
L
V
L
------
95
PsiBlast_CBE
68.48
33%
-3
- C7 -
-
1EKX
2
PYRB_ECOLI
C:
[9-305]
---------
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
L
K
A
N
P
Q
P
E
L
L
K
H
K
V
I
A
S
C
F
F
E
A
S
T
R
T
R
L
S
F
E
T
S
M
H
R
L
G
A
S
V
V
G
F
-
S
DS
A
N
T
--
S
L
G
K
K
G
E
T
L
A
D
T
I
S
V
I
S
T
Y
-
V
D
A
I
V
M
R
H
P
Q
E
-
G
A
-
A
R
-
L
A
T
E
F
S
-
G
N
V
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
Q
E
T
Q
G
R
L
D
N
L
H
V
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
D
G
N
R
F
Y
F
I
A
P
D
A
L
--
A
M
-----
P
Q
Y
ILDMLDEKG
I
--
A
--------
W
S
L
H
S
----
S
I
E
E
V
M
A
E
V
D
I
L
Y
M
T
R
V
Q
K
E
R
L
D
P
S
-----
E
Y
A
N
V
K
A
Q
F
V
L
R
A
S
D
L
H
N
A
K
A
N
M
K
V
L
H
P
L
P
--
R
V
D
E
I
A
T
D
V
D
K
T
P
H
A
W
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
A
L
V
L
------
117
PsiBlast_CBE
68.37
33%
-13
- C7 -
-
2HSE
3
PYRB_ECOLI
A:
[8-304]
---------
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
L
K
A
N
P
Q
P
E
L
L
K
H
K
V
I
A
S
C
F
F
E
A
S
T
R
T
R
L
S
F
E
T
S
M
H
R
L
G
A
S
V
V
G
F
-
S
DS
A
N
T
--
S
L
G
K
K
G
E
T
L
A
D
T
I
S
V
I
S
T
Y
-
V
D
A
I
V
M
R
H
P
Q
E
-
G
A
-
A
R
-
L
A
T
E
F
S
-
G
N
V
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
Q
E
T
Q
G
R
L
D
N
L
H
V
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
D
G
N
R
F
Y
F
I
A
P
D
A
L
--
A
M
-----
P
Q
Y
I
L
D
M
L
D
E
K
G
I
--
A
--------
W
S
L
H
S
----
S
I
E
E
V
M
A
E
V
D
I
L
Y
M
T
R
V
Q
K
E
R
L
---
A
P
S
--
E
Y
A
N
V
K
A
Q
F
V
L
R
A
S
D
L
H
N
A
K
A
N
M
K
V
L
H
P
L
P
--
R
V
D
E
I
A
T
D
V
D
K
T
P
H
A
W
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
A
L
V
L
------
80
PsiBlast_CBE
68.26
33%
-5
- C7 -
-
1R0C
1
PYRB_ECOLI
A:
[8-304]
---------
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
L
K
A
N
P
Q
P
E
L
L
K
H
K
V
I
A
S
C
F
F
E
A
S
T
R
T
R
L
S
F
E
T
S
M
H
R
L
G
A
S
V
V
G
F
-
S
DS
A
N
T
--
S
L
G
K
K
G
E
T
L
A
D
T
I
S
V
I
S
T
Y
-
V
D
A
I
V
M
R
H
P
Q
E
-
G
A
-
A
R
-
L
A
T
E
F
S
-
G
N
V
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
Q
E
T
Q
G
R
L
D
N
L
H
V
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
D
G
N
R
F
Y
F
I
A
P
D
A
L
--
A
M
-----
P
Q
Y
I
L
D
M
L
D
E
K
G
I
--
A
--------
W
S
L
H
S
----
S
I
E
E
V
M
A
E
V
D
I
L
Y
M
T
R
V
Q
K
E
R
L
D
P
S
-----
E
Y
A
N
V
K
A
Q
F
V
L
R
A
S
D
L
H
N
A
K
A
N
M
K
V
L
H
P
L
P
--
R
V
D
E
I
A
T
D
V
D
K
T
P
H
A
W
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
A
L
V
L
------
77
PsiBlast_CBE
68.18
33%
-4
- C7 -
-
1ZA2
2
PYRB_ECOLI
C:
[8-304]
---------
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
L
K
A
N
P
Q
P
E
L
L
K
H
K
V
I
A
S
C
F
F
E
A
S
T
R
T
R
L
S
F
E
T
S
M
H
R
L
G
A
S
V
V
G
F
-
S
DS
A
N
T
--
S
L
G
K
K
G
E
T
L
A
D
T
I
S
V
I
S
T
Y
-
V
D
A
I
V
M
R
H
P
Q
E
-
G
A
-
A
R
-
L
A
T
E
F
S
-
G
N
V
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
Q
E
T
Q
G
R
L
D
N
L
H
V
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
D
G
N
R
F
Y
F
I
A
P
D
A
L
--
A
M
-----
P
Q
Y
ILDMLDEKG
I
--
A
--------
W
S
L
H
S
----
S
I
E
E
V
M
A
E
V
D
I
L
Y
M
T
R
V
Q
K
E
R
L
D
P
S
-----
E
Y
A
N
V
K
A
Q
F
V
L
R
A
S
D
L
H
N
A
K
A
N
M
K
V
L
H
P
L
P
--
R
V
D
E
I
A
T
D
V
D
K
T
P
H
A
W
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
A
L
V
L
------
109
PsiBlast_CBE
68.02
33%
-2
- C7 -
-
3AT1
1
PYRB_ECOLI
A:
[8-304]
---------
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
L
K
A
N
P
Q
P
E
L
L
K
H
K
V
I
A
S
C
F
F
E
A
S
T
R
T
R
L
S
F
Q
T
S
M
H
R
L
G
A
S
V
V
G
F
-
S
DS
A
N
T
--
S
L
G
K
K
G
E
T
L
A
D
T
I
S
V
I
S
T
Y
-
V
D
A
I
V
M
R
H
P
Q
E
-
G
A
-
A
R
-
L
A
T
E
F
S
-
G
N
V
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
Q
Q
T
E
G
R
L
D
N
L
H
V
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
D
G
N
R
F
Y
F
I
A
P
D
A
L
--
A
M
-----
P
E
Y
I
L
D
M
L
D
E
K
G
I
--
A
--------
W
S
L
H
S
----
S
I
E
E
V
M
A
E
V
D
I
L
Y
M
T
R
V
Q
K
E
R
L
D
P
S
-----
E
Y
A
N
V
K
A
Q
F
V
L
R
A
S
D
L
H
N
A
K
A
N
M
K
V
L
H
P
L
P
--
R
V
D
E
I
A
T
D
V
D
K
T
P
H
A
W
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
A
L
V
L
------
122
PsiBlast_CBE
67.94
33%
-3
- C7 -
-
1TU0
1
PYRB_ECOLI
A:
[8-304]
---------
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
L
K
A
N
P
Q
P
E
L
L
K
H
K
V
I
A
S
C
F
F
A
A
S
T
R
T
R
L
S
F
E
T
S
M
H
R
L
G
A
S
V
V
G
F
-
S
DS
A
N
T
--
S
L
G
K
K
G
E
T
L
A
D
T
I
S
V
I
S
T
Y
-
V
D
A
I
V
M
R
H
P
Q
E
-
G
A
-
A
R
-
L
A
T
E
F
S
-
G
N
V
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
Q
E
T
Q
G
R
L
D
N
L
H
V
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
D
G
N
R
F
Y
F
I
A
P
D
A
L
--
A
M
-----
P
Q
Y
I
L
D
M
L
D
E
K
G
I
--
A
--------
W
S
L
H
S
----
S
I
E
E
V
M
A
E
V
D
I
L
Y
M
T
R
V
Q
K
E
R
L
D
P
S
-----
E
Y
A
N
V
K
A
Q
F
V
L
R
A
S
D
L
H
N
A
K
A
N
M
K
V
L
H
P
L
P
--
R
V
D
E
I
A
T
D
V
D
K
T
P
H
A
W
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
A
L
V
L
------
78
PsiBlast_CBE
67.93
33%
-5
- C7 -
-
1ZA2
2
PYRB_ECOLI
A:
[8-304]
---------
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
L
K
A
N
P
Q
P
E
L
L
K
H
K
V
I
A
S
C
F
F
E
A
S
T
R
T
R
L
S
F
E
T
S
M
H
R
L
G
A
S
V
V
G
F
-
S
DS
A
N
T
--
S
L
G
K
K
G
E
T
L
A
D
T
I
S
V
I
S
T
Y
-
V
D
A
I
V
M
R
H
P
Q
E
-
G
A
-
A
R
-
L
A
T
E
F
S
-
G
N
V
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
Q
E
T
Q
G
R
L
D
N
L
H
V
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
D
G
N
R
F
Y
F
I
A
P
D
A
L
--
A
M
-----
P
Q
Y
I
L
D
M
L
D
E
K
G
I
--
A
--------
W
S
L
H
S
----
S
I
E
E
V
M
A
E
V
D
I
L
Y
M
T
R
V
Q
K
E
R
L
D
P
S
-----
E
Y
A
N
V
K
A
Q
F
V
L
R
A
S
D
L
H
N
A
K
A
N
M
K
V
L
H
P
L
P
--
R
V
D
E
I
A
T
D
V
D
K
T
P
H
A
W
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
A
L
V
L
------
69
PsiBlast_CBE
67.83
33%
-1
- C7 -
-
2FZK
1
PYRB_ECOLI
C:
[8-304]
---------
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
L
K
A
N
P
Q
P
E
L
L
K
H
K
V
I
A
S
C
F
F
E
A
S
T
R
T
R
L
S
F
E
T
S
M
H
R
L
G
A
S
V
V
G
F
-
S
DS
A
N
T
--
S
L
G
K
K
G
E
T
L
A
D
T
I
S
V
I
S
T
Y
-
V
D
A
I
V
M
R
H
P
Q
E
-
G
A
-
A
R
-
L
A
T
E
F
S
-
G
N
V
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
Q
E
T
Q
G
R
L
D
N
L
H
V
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
D
G
N
R
F
Y
F
I
A
P
D
A
L
--
A
M
-----
P
Q
Y
ILDMLDEKG
I
--
A
--------
W
S
L
H
S
----
S
I
E
E
V
M
A
E
V
D
I
L
Y
M
T
R
V
Q
K
E
R
L
D
P
S
-----
E
Y
A
N
V
K
A
Q
F
V
L
R
A
S
D
L
H
N
A
K
A
N
M
K
V
L
H
P
L
P
--
R
V
D
E
I
A
T
D
V
D
K
T
P
H
A
W
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
A
L
V
L
------
121
PsiBlast_CBE
67.82
33%
-3
- C7 -
-
1TU0
1
PYRB_ECOLI
C:
[8-304]
---------
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
L
K
A
N
P
Q
P
E
L
L
K
H
K
V
I
A
S
C
F
F
A
A
S
T
R
T
R
L
S
F
E
T
S
M
H
R
L
G
A
S
V
V
G
F
-
S
DS
A
N
T
--
S
L
G
K
K
G
E
T
L
A
D
T
I
S
V
I
S
T
Y
-
V
D
A
I
V
M
R
H
P
Q
E
-
G
A
-
A
R
-
L
A
T
E
F
S
-
G
N
V
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
Q
E
T
Q
G
R
L
D
N
L
H
V
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
D
G
N
R
F
Y
F
I
A
P
D
A
L
--
A
M
-----
P
Q
Y
ILDMLDEKG
I
--
A
--------
W
S
L
H
S
----
S
I
E
E
V
M
A
E
V
D
I
L
Y
M
T
R
V
Q
K
E
R
L
D
P
S
-----
E
Y
A
N
V
K
A
Q
F
V
L
R
A
S
D
L
H
N
A
K
A
N
M
K
V
L
H
P
L
P
--
R
V
D
E
I
A
T
D
V
D
K
T
P
H
A
W
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
A
L
V
L
------
73
PsiBlast_CBE
67.60
33%
-1
- C7 -
-
2FZC
1
PYRB_ECOLI
C:
[8-304]
---------
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
L
K
A
N
P
Q
P
E
L
L
K
H
K
V
I
A
S
C
F
F
E
A
S
T
R
T
R
L
S
F
E
T
S
M
H
R
L
G
A
S
V
V
G
F
-
S
DS
A
N
T
--
S
L
G
K
K
G
E
T
L
A
D
T
I
S
V
I
S
T
Y
-
V
D
A
I
V
M
R
H
P
Q
E
-
G
A
-
A
R
-
L
A
T
E
F
S
-
G
N
V
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
Q
E
T
Q
G
R
L
D
N
L
H
V
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
D
G
N
R
F
Y
F
I
A
P
D
A
L
--
A
M
-----
P
Q
Y
ILDMLDEKG
I
--
A
--------
W
S
L
H
S
----
S
I
E
E
V
M
A
E
V
D
I
L
Y
M
T
R
V
Q
K
E
R
L
D
P
S
-----
E
Y
A
N
V
K
A
Q
F
V
L
R
A
S
D
L
H
N
A
K
A
N
M
K
V
L
H
P
L
P
--
R
V
D
E
I
A
T
D
V
D
K
T
P
H
A
W
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
A
L
V
L
------
103
PsiBlast_CBE
67.48
33%
-4
- C7 -
-
8ATC
1
PYRB_ECOLI
A:
[8-304]
---------
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
L
K
A
N
P
Q
P
E
L
L
K
H
K
V
I
A
S
C
F
F
E
A
S
T
R
T
R
L
S
F
Q
T
S
M
H
R
L
G
A
S
V
V
G
F
-
S
DS
A
N
T
--
S
L
G
K
K
G
E
T
L
A
D
T
I
S
V
I
S
T
Y
-
V
D
A
I
V
M
R
H
P
Q
E
-
G
A
-
A
R
-
L
A
T
E
F
S
-
G
N
V
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
Q
Q
T
E
G
R
L
D
N
L
H
V
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
D
G
N
R
F
Y
F
I
A
P
D
A
L
--
A
M
-----
P
E
Y
I
L
D
M
L
D
E
K
G
I
--
A
--------
W
S
L
H
S
----
S
I
E
E
V
M
A
E
V
D
I
L
Y
M
T
R
V
Q
K
E
R
L
D
P
S
-----
E
Y
A
N
V
K
A
Q
F
V
L
R
A
S
D
L
H
N
A
K
A
N
M
K
V
L
H
P
L
P
--
R
V
D
E
I
A
T
D
V
D
K
T
P
H
A
W
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
A
L
V
L
------
72
PsiBlast_CBE
67.48
33%
1
- C7 -
-
2FZG
1
PYRB_ECOLI
A:
[8-304]
---------
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
L
K
A
N
P
Q
P
E
L
L
K
H
K
V
I
A
S
C
F
F
E
A
S
T
R
T
R
L
S
F
E
T
S
M
H
R
L
G
A
S
V
V
G
F
-
S
DS
A
N
T
--
S
L
G
K
K
G
E
T
L
A
D
T
I
S
V
I
S
T
Y
-
V
D
A
I
V
M
R
H
P
Q
E
-
G
A
-
A
R
-
L
A
T
E
F
S
-
G
N
V
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
Q
E
T
Q
G
R
L
D
N
L
H
V
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
D
G
N
R
F
Y
F
I
A
P
D
A
L
--
A
M
-----
P
Q
Y
I
L
D
M
L
D
E
K
G
I
--
A
--------
W
S
L
H
S
----
S
I
E
E
V
M
A
E
V
D
I
L
Y
M
T
R
V
Q
K
E
R
L
D
P
S
-----
E
Y
A
N
V
K
A
Q
F
V
L
R
A
S
D
L
H
N
A
K
A
N
M
K
V
L
H
P
L
P
--
R
V
D
E
I
A
T
D
V
D
K
T
P
H
A
W
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
A
L
V
L
------
74
PsiBlast_CBE
67.44
33%
-2
- C7 -
-
2FZC
1
PYRB_ECOLI
A:
[8-304]
---------
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
L
K
A
N
P
Q
P
E
L
L
K
H
K
V
I
A
S
C
F
F
E
A
S
T
R
T
R
L
S
F
E
T
S
M
H
R
L
G
A
S
V
V
G
F
-
S
DS
A
N
T
--
S
L
G
K
K
G
E
T
L
A
D
T
I
S
V
I
S
T
Y
-
V
D
A
I
V
M
R
H
P
Q
E
-
G
A
-
A
R
-
L
A
T
E
F
S
-
G
N
V
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
Q
E
T
Q
G
R
L
D
N
L
H
V
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
D
G
N
R
F
Y
F
I
A
P
D
A
L
--
A
M
-----
P
Q
Y
I
L
D
M
L
D
E
K
G
I
--
A
--------
W
S
L
H
S
----
S
I
E
E
V
M
A
E
V
D
I
L
Y
M
T
R
V
Q
K
E
R
L
D
P
S
-----
E
Y
A
N
V
K
A
Q
F
V
L
R
A
S
D
L
H
N
A
K
A
N
M
K
V
L
H
P
L
P
--
R
V
D
E
I
A
T
D
V
D
K
T
P
H
A
W
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
A
L
V
L
------
107
PsiBlast_CBE
67.30
33%
-3
- C7 -
-
7AT1
2
PYRB_ECOLI
A:
[8-304]
---------
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
L
K
A
N
P
Q
P
E
L
L
K
H
K
V
I
A
S
C
F
F
E
A
S
T
R
T
R
L
S
F
Q
T
S
M
H
R
L
G
A
S
V
V
G
F
-
S
DS
A
N
T
--
S
L
G
K
K
G
E
T
L
A
D
T
I
S
V
I
S
T
Y
-
V
D
A
I
V
M
R
H
P
Q
E
-
G
A
-
A
R
-
L
A
T
E
F
S
-
G
N
V
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
Q
Q
T
E
G
R
L
D
N
L
H
V
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
D
G
N
R
F
Y
F
I
A
P
D
A
L
--
A
M
-----
P
E
Y
I
L
D
M
L
D
E
K
G
I
--
A
--------
W
S
L
H
S
----
S
I
E
E
V
M
A
E
V
D
I
L
Y
M
T
R
V
Q
K
E
R
L
D
P
S
-----
E
Y
A
N
V
K
A
Q
F
V
L
R
A
S
D
L
H
N
A
K
A
N
M
K
V
L
H
P
L
P
--
R
V
D
E
I
A
T
D
V
D
K
T
P
H
A
W
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
A
L
V
L
------
76
PsiBlast_CBE
67.27
33%
-6
- C7 -
-
2AIR
2
PYRB_ECOLI
A:
[8-304]
---------
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
L
K
A
N
P
Q
P
E
L
L
K
H
K
V
I
A
S
C
F
F
E
A
S
T
R
T
R
L
S
F
E
T
S
M
H
R
L
G
A
S
V
V
G
F
-
S
DS
A
N
T
--
S
L
G
K
K
G
E
T
L
A
D
T
I
S
V
I
S
T
Y
-
V
D
A
I
V
M
R
H
P
Q
E
-
G
A
-
A
R
-
L
A
T
E
F
S
-
G
N
V
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
Q
E
T
Q
G
R
L
D
N
L
H
V
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
D
G
N
R
F
Y
F
I
A
P
D
A
L
--
A
M
-----
P
Q
Y
I
L
D
M
L
D
E
K
G
I
--
A
--------
W
S
L
H
S
----
S
I
E
E
V
M
A
E
V
D
I
L
Y
M
T
R
V
Q
K
E
R
L
D
P
S
-----
E
Y
A
N
V
K
A
Q
F
V
L
R
A
S
D
L
H
N
A
K
A
N
M
K
V
L
H
P
L
P
--
R
V
D
E
I
A
T
D
V
D
K
T
P
H
A
W
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
A
L
V
L
------
116
PsiBlast_CBE
67.25
33%
-9
- C7 -
-
2HSE
2
PYRB_ECOLI
C:
[8-304]
---------
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
L
K
A
N
P
Q
P
E
L
L
K
H
K
V
I
A
S
C
F
F
E
A
S
T
R
T
R
L
S
F
E
T
S
M
H
R
L
G
A
S
V
V
G
F
-
S
DS
A
N
T
--
S
L
G
K
K
G
E
T
L
A
D
T
I
S
V
I
S
T
Y
-
V
D
A
I
V
M
R
H
P
Q
E
-
G
A
-
A
R
-
L
A
T
E
F
S
-
G
N
V
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
Q
E
T
Q
G
R
L
D
N
L
H
V
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
D
G
N
R
F
Y
F
I
A
P
D
A
L
--
A
M
-----
P
Q
Y
ILDMLDEKG
I
--
A
--------
W
S
L
H
S
----
S
I
E
E
V
M
A
E
V
D
I
L
Y
M
T
R
V
Q
K
E
R
L
---
A
P
S
--
E
Y
A
N
V
K
A
Q
F
V
L
R
A
S
D
L
H
N
A
K
A
N
M
K
V
L
H
P
L
P
--
R
V
D
E
I
A
T
D
V
D
K
T
P
H
A
W
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
A
L
V
L
------
59
PsiBlast_CBE
67.24
33%
-1
- C7 -
-
4KGV
1
?
A:
[8-304]
---------
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
L
K
A
N
P
Q
P
E
L
L
K
H
K
V
I
A
S
C
F
F
E
A
S
T
R
T
R
L
S
F
E
T
S
M
H
R
L
G
A
S
V
V
G
F
-
S
DS
A
N
T
--
S
L
G
K
K
G
E
T
L
A
D
T
I
S
V
I
S
T
Y
-
V
D
A
I
V
M
R
H
P
Q
E
-
G
A
-
A
R
-
L
A
T
E
F
S
-
G
N
V
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
Q
E
T
Q
G
R
L
D
N
L
H
V
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
D
G
N
R
F
Y
F
I
A
P
D
A
L
--
A
M
-----
P
Q
Y
I
L
D
M
L
D
E
K
G
I
--
A
--------
W
S
L
H
S
----
S
I
E
E
V
M
A
E
V
D
I
L
Y
M
T
R
V
Q
K
E
R
L
D
P
S
-----
E
Y
A
N
V
K
A
Q
F
V
L
R
A
S
D
L
H
N
A
K
A
N
M
K
V
L
H
P
L
P
--
R
V
D
E
I
A
T
D
V
D
K
T
P
H
A
W
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
A
L
V
L
------
57
PsiBlast_CBE
66.98
33%
-2
- C7 -
-
4KGX
1
?
A:
[8-304]
---------
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
L
K
A
N
P
Q
P
E
L
L
K
H
K
V
I
A
S
C
F
F
E
A
S
T
R
T
R
L
S
F
E
T
S
M
H
R
L
G
A
S
V
V
G
F
-
S
DS
A
N
T
--
S
L
G
K
K
G
E
T
L
A
D
T
I
S
V
I
S
T
Y
-
V
D
A
I
V
M
R
H
P
Q
E
-
G
A
-
A
R
-
L
A
T
E
F
S
-
G
N
V
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
Q
E
T
Q
G
R
L
D
N
L
H
V
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
D
G
N
R
F
Y
F
I
A
P
D
A
L
--
A
M
-----
P
Q
Y
I
L
D
M
L
D
E
K
G
I
--
A
--------
W
S
L
H
S
----
S
I
E
E
V
M
A
E
V
D
I
L
Y
M
T
R
V
Q
K
E
R
L
D
P
S
-----
E
Y
A
N
V
K
A
Q
F
V
L
R
A
S
D
L
H
N
A
K
A
N
M
K
V
L
H
P
L
P
--
R
V
D
E
I
A
T
D
V
D
K
T
P
H
A
W
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
A
L
V
L
------
79
PsiBlast_CBE
66.87
33%
-6
- C7 -
-
1R0C
1
PYRB_ECOLI
G:
[8-304]
---------
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
L
K
A
N
P
Q
P
E
L
L
K
H
K
V
I
A
S
C
F
F
E
A
S
T
R
T
R
L
S
F
E
T
S
M
H
R
L
G
A
S
V
V
G
F
-
S
DS
A
N
T
--
S
L
G
K
K
G
E
T
L
A
D
T
I
S
V
I
S
T
Y
-
V
D
A
I
V
M
R
H
P
Q
E
-
G
A
-
A
R
-
L
A
T
E
F
S
-
G
N
V
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
Q
E
T
Q
G
R
L
D
N
L
H
V
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
D
G
N
R
F
Y
F
I
A
P
D
A
L
--
A
M
-----
P
Q
Y
ILDMLDEKG
I
--
A
--------
W
S
L
H
S
----
S
I
E
E
V
M
A
E
V
D
I
L
Y
M
T
R
V
Q
K
E
R
L
D
P
S
-----
E
Y
A
N
V
K
A
Q
F
V
L
R
A
S
D
L
H
N
A
K
A
N
M
K
V
L
H
P
L
P
--
R
V
D
E
I
A
T
D
V
D
K
T
P
H
A
W
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
A
L
V
L
------
51
PsiBlast_CBE
66.86
33%
-3
- C7 -
-
4KH1
1
?
A:
[8-304]
---------
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
L
K
A
N
P
Q
P
E
L
L
K
H
K
V
I
A
S
C
F
F
E
A
S
T
R
T
R
L
S
F
E
T
S
M
H
R
L
G
A
S
V
V
G
F
-
S
DS
A
N
T
--
S
L
G
K
K
G
E
T
L
A
D
T
I
S
V
I
S
T
Y
-
V
D
A
I
V
M
R
H
P
Q
E
-
G
A
-
A
R
-
L
A
T
E
F
S
-
G
N
V
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
Q
E
T
Q
G
R
L
D
N
L
H
V
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
D
G
N
R
F
Y
F
I
A
P
D
A
L
--
A
M
-----
P
Q
Y
I
L
D
M
L
D
E
K
G
I
--
A
--------
W
S
L
H
S
----
S
I
E
E
V
M
A
E
V
D
I
L
Y
M
T
R
V
Q
K
E
R
L
D
P
S
-----
E
Y
A
N
V
K
A
Q
F
V
L
R
A
S
D
L
H
N
A
K
A
N
M
K
V
L
H
P
L
P
--
R
V
D
E
I
A
T
D
V
D
K
T
P
H
A
W
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
A
L
V
L
------
58
PsiBlast_CBE
66.83
33%
2
- C7 -
-
4KGV
1
?
C:
[8-304]
---------
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
L
K
A
N
P
Q
P
E
L
L
K
H
K
V
I
A
S
C
F
F
E
A
S
T
R
T
R
L
S
F
E
T
S
M
H
R
L
G
A
S
V
V
G
F
-
S
DS
A
N
T
--
S
L
G
K
K
G
E
T
L
A
D
T
I
S
V
I
S
T
Y
-
V
D
A
I
V
M
R
H
P
Q
E
-
G
A
-
A
R
-
L
A
T
E
F
S
-
G
N
V
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
Q
E
T
Q
G
R
L
D
N
L
H
V
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
D
G
N
R
F
Y
F
I
A
P
D
A
L
--
A
M
-----
P
Q
Y
ILDMLDEKG
I
--
A
--------
W
S
L
H
S
----
S
I
E
E
V
M
A
E
V
D
I
L
Y
M
T
R
V
Q
K
E
R
L
D
P
S
-----
E
Y
A
N
V
K
A
Q
F
V
L
R
A
S
D
L
H
N
A
K
A
N
M
K
V
L
H
P
L
P
--
R
V
D
E
I
A
T
D
V
D
K
T
P
H
A
W
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
A
L
V
L
------
102
PsiBlast_CBE
66.79
33%
1
- C7 -
-
8ATC
1
PYRB_ECOLI
C:
[8-304]
---------
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
L
K
A
N
P
Q
P
E
L
L
K
H
K
V
I
A
S
C
F
F
E
A
S
T
R
T
R
L
S
F
Q
T
S
M
H
R
L
G
A
S
V
V
G
F
-
S
DS
A
N
T
--
S
L
G
K
K
G
E
T
L
A
D
T
I
S
V
I
S
T
Y
-
V
D
A
I
V
M
R
H
P
Q
E
-
G
A
-
A
R
-
L
A
T
E
F
S
-
G
N
V
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
Q
Q
T
E
G
R
L
D
N
L
H
V
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
D
G
N
R
F
Y
F
I
A
P
D
A
L
--
A
M
-----
P
E
Y
ILDMLDEKG
I
--
A
--------
W
S
L
H
S
----
S
I
E
E
V
M
A
E
V
D
I
L
Y
M
T
R
V
Q
K
E
R
L
D
P
S
-----
E
Y
A
N
V
K
A
Q
F
V
L
R
A
S
D
L
H
N
A
K
A
N
M
K
V
L
H
P
L
P
--
R
V
D
E
I
A
T
D
V
D
K
T
P
H
A
W
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
A
L
V
L
------
94
PsiBlast_CBE
66.79
33%
1
- C7 -
-
1D09
1
PYRB_ECOLI
A:
[8-304]
---------
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
L
K
A
N
P
Q
P
E
L
L
K
H
K
V
I
A
S
C
F
F
E
A
S
T
R
T
R
L
S
F
E
T
S
M
H
R
L
G
A
S
V
V
G
F
-
S
DS
A
N
T
--
S
L
G
K
K
G
E
T
L
A
D
T
I
S
V
I
S
T
Y
-
V
D
A
I
V
M
R
H
P
Q
E
-
G
A
-
A
R
-
L
A
T
E
F
S
-
G
N
V
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
Q
Q
T
Q
G
R
L
D
N
L
H
V
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
D
G
N
R
F
Y
F
I
A
P
D
A
L
--
A
M
-----
P
E
Y
I
L
D
M
L
D
E
K
G
I
--
A
--------
W
S
L
H
S
----
S
I
E
E
V
M
A
E
V
D
I
L
Y
M
T
R
V
Q
K
E
R
L
D
P
S
-----
E
Y
A
N
V
K
A
Q
F
V
L
R
A
S
D
L
H
N
A
K
A
N
M
K
V
L
H
P
L
P
--
R
V
D
E
I
A
T
D
V
D
K
T
P
H
A
W
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
A
L
V
L
------
75
PsiBlast_CBE
66.76
33%
-1
- C7 -
-
2AIR
2
PYRB_ECOLI
G:
[8-304]
---------
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
L
K
A
N
P
Q
P
E
L
L
K
H
K
V
I
A
S
C
F
F
E
A
S
T
R
T
R
L
S
F
E
T
S
M
H
R
L
G
A
S
V
V
G
F
-
S
DS
A
N
T
--
S
L
G
K
K
G
E
T
L
A
D
T
I
S
V
I
S
T
Y
-
V
D
A
I
V
M
R
H
P
Q
E
-
G
A
-
A
R
-
L
A
T
E
F
S
-
G
N
V
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
Q
E
T
Q
G
R
L
D
N
L
H
V
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
D
G
N
R
F
Y
F
I
A
P
D
A
L
--
A
M
-----
P
Q
Y
ILDMLDEKG
I
--
A
--------
W
S
L
H
S
----
S
I
E
E
V
M
A
E
V
D
I
L
Y
M
T
R
V
Q
K
E
R
L
D
P
S
-----
E
Y
A
N
V
K
A
Q
F
V
L
R
A
S
D
L
H
N
A
K
A
N
M
K
V
L
H
P
L
P
--
R
V
D
E
I
A
T
D
V
D
K
T
P
H
A
W
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
A
L
V
L
------
61
PsiBlast_CBE
66.57
33%
-4
- C7 -
-
4F04
1
PYRB_ECOLI
C:
[8-304]
---------
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
L
K
A
N
P
Q
P
E
L
L
K
H
K
V
I
A
S
C
F
F
E
A
S
T
R
T
R
L
S
F
E
T
S
M
H
R
L
G
A
S
V
V
G
F
-
S
DS
A
N
T
--
S
L
G
K
K
G
E
T
L
A
D
T
I
S
V
I
S
T
Y
-
V
D
A
I
V
M
R
H
P
Q
E
-
G
A
-
A
R
-
L
A
T
E
F
S
-
G
N
V
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
Q
E
T
Q
G
R
L
D
N
L
H
V
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
D
G
N
R
F
Y
F
I
A
P
D
A
L
--
A
M
-----
P
Q
Y
ILDMLDEKG
I
--
A
--------
W
S
L
H
S
----
S
I
E
E
V
M
A
E
V
D
I
L
Y
M
T
R
V
Q
K
E
R
L
D
P
S
-----
E
Y
A
N
V
K
A
Q
F
V
L
R
A
S
D
L
H
N
A
K
A
N
M
K
V
L
H
P
L
P
--
R
V
D
E
I
A
T
D
V
D
K
T
P
H
A
W
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
A
L
V
L
------
106
PsiBlast_CBE
66.56
33%
-1
* C7 *
-
7AT1
2
PYRB_ECOLI
C:
[8-304]
---------
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
L
K
A
N
P
Q
P
E
L
L
K
H
K
V
I
A
S
C
F
F
E
A
S
T
R
T
R
L
S
F
Q
T
S
M
H
R
L
G
A
S
V
V
G
F
-
S
DS
A
N
T
--
S
L
G
K
K
G
E
T
L
A
D
T
I
S
V
I
S
T
Y
-
V
D
A
I
V
M
R
H
P
Q
E
-
G
A
-
A
R
-
L
A
T
E
F
S
-
G
N
V
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
Q
Q
T
E
G
R
L
D
N
L
H
V
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
D
G
N
R
F
Y
F
I
A
P
D
A
L
--
A
M
-----
P
E
Y
ILDMLDEKG
I
--
A
--------
W
S
L
H
S
----
S
I
E
E
V
M
A
E
V
D
I
L
Y
M
T
R
V
Q
K
E
R
L
D
P
S
-----
E
Y
A
N
V
K
A
Q
F
V
L
R
A
S
D
L
H
N
A
K
A
N
M
K
V
L
H
P
L
P
--
R
V
D
E
I
A
T
D
V
D
K
T
P
H
A
W
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
A
L
V
L
------
104
PsiBlast_CBE
66.52
33%
4
- C7 -
-
8AT1
2
PYRB_ECOLI
C:
[8-304]
---------
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
L
K
A
N
P
Q
P
E
L
L
K
H
K
V
I
A
S
C
F
F
E
A
S
T
R
T
R
L
S
F
Q
T
S
M
H
R
L
G
A
S
V
V
G
F
-
S
DS
A
N
T
--
S
L
G
K
K
G
E
T
L
A
D
T
I
S
V
I
S
T
Y
-
V
D
A
I
V
M
R
H
P
Q
E
-
G
A
-
A
R
-
L
A
T
E
F
S
-
G
N
V
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
Q
Q
T
E
G
R
L
D
N
L
H
V
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
D
G
N
R
F
Y
F
I
A
P
D
A
L
--
A
M
-----
P
E
Y
ILDMLDEKG
I
--
A
--------
W
S
L
H
S
----
S
I
E
E
V
M
A
E
V
D
I
L
Y
M
T
R
V
Q
K
E
R
L
D
P
S
-----
E
Y
A
N
V
K
A
Q
F
V
L
R
A
S
D
L
H
N
A
K
A
N
M
K
V
L
H
P
L
P
--
R
V
D
E
I
A
T
D
V
D
K
T
P
H
A
W
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
A
L
V
L
------
53
PsiBlast_CBE
66.52
33%
-3
- C7 -
-
4KH0
1
?
A:
[8-304]
---------
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
L
K
A
N
P
Q
P
E
L
L
K
H
K
V
I
A
S
C
F
F
E
A
S
T
R
T
R
L
S
F
E
T
S
M
H
R
L
G
A
S
V
V
G
F
-
S
DS
A
N
T
--
S
L
G
K
K
G
E
T
L
A
D
T
I
S
V
I
S
T
Y
-
V
D
A
I
V
M
R
H
P
Q
E
-
G
A
-
A
R
-
L
A
T
E
F
S
-
G
N
V
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
Q
E
T
Q
G
R
L
D
N
L
H
V
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
D
G
N
R
F
Y
F
I
A
P
D
A
L
--
A
M
-----
P
Q
Y
I
L
D
M
L
D
E
K
G
I
--
A
--------
W
S
L
H
S
----
S
I
E
E
V
M
A
E
V
D
I
L
Y
M
T
R
V
Q
K
E
R
L
D
P
S
-----
E
Y
A
N
V
K
A
Q
F
V
L
R
A
S
D
L
H
N
A
K
A
N
M
K
V
L
H
P
L
P
--
R
V
D
E
I
A
T
D
V
D
K
T
P
H
A
W
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
A
L
V
L
------
115
PsiBlast_CBE
66.49
33%
-2
- C7 -
-
1AT1
1
PYRB_ECOLI
A:
[8-304]
---------
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
L
K
A
N
P
Q
P
E
L
L
K
H
K
V
I
A
S
C
F
F
E
A
S
T
R
T
R
L
S
F
Q
T
S
M
H
R
L
G
A
S
V
V
G
F
-
S
DS
A
N
T
--
S
L
G
K
K
G
E
T
L
A
D
T
I
S
V
I
S
T
Y
-
V
D
A
I
V
M
R
H
P
Q
E
-
G
A
-
A
R
-
L
A
T
E
F
S
-
G
N
V
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
Q
Q
T
E
G
R
L
D
N
L
H
V
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
D
G
N
R
F
Y
F
I
A
P
D
A
L
--
A
M
-----
P
E
Y
I
L
D
M
L
D
E
K
G
I
--
A
--------
W
S
L
H
S
----
S
I
E
E
V
M
A
E
V
D
I
L
Y
M
T
R
V
Q
K
E
R
L
D
P
S
-----
E
Y
A
N
V
K
A
Q
F
V
L
R
A
S
D
L
H
N
A
K
A
N
M
K
V
L
H
P
L
P
--
R
V
D
E
I
A
T
D
V
D
K
T
P
H
A
W
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
A
L
V
L
------
97
PsiBlast_CBE
66.49
33%
-1
- C7 -
-
1EKX
2
PYRB_ECOLI
A:
[9-305]
---------
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
L
K
A
N
P
Q
P
E
L
L
K
H
K
V
I
A
S
C
F
F
E
A
S
T
R
T
R
L
S
F
E
T
S
M
H
R
L
G
A
S
V
V
G
F
-
S
DS
A
N
T
--
S
L
G
K
K
G
E
T
L
A
D
T
I
S
V
I
S
T
Y
-
V
D
A
I
V
M
R
H
P
Q
E
-
G
A
-
A
R
-
L
A
T
E
F
S
-
G
N
V
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
Q
E
T
Q
G
R
L
D
N
L
H
V
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
D
G
N
R
F
Y
F
I
A
P
D
A
L
--
A
M
-----
P
Q
Y
I
L
D
M
L
D
E
K
G
I
--
A
--------
W
S
L
H
S
----
S
I
E
E
V
M
A
E
V
D
I
L
Y
M
T
R
V
Q
K
E
R
L
D
P
S
-----
E
Y
A
N
V
K
A
Q
F
V
L
R
A
S
D
L
H
N
A
K
A
N
M
K
V
L
H
P
L
P
--
R
V
D
E
I
A
T
D
V
D
K
T
P
H
A
W
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
A
L
V
L
------
96
PsiBlast_CBE
66.32
33%
0
- C7 -
-
1EKX
2
PYRB_ECOLI
B:
[9-305]
---------
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
L
K
A
N
P
Q
P
E
L
L
K
H
K
V
I
A
S
C
F
F
E
A
S
T
R
T
R
L
S
F
E
T
S
M
H
R
L
G
A
S
V
V
G
F
-
S
DS
A
N
T
--
S
L
G
K
K
G
E
T
L
A
D
T
I
S
V
I
S
T
Y
-
V
D
A
I
V
M
R
H
P
Q
E
-
G
A
-
A
R
-
L
A
T
E
F
S
-
G
N
V
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
Q
E
T
Q
G
R
L
D
N
L
H
V
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
D
G
N
R
F
Y
F
I
A
P
D
A
L
--
A
M
-----
P
Q
Y
ILDMLDEKG
I
--
A
--------
W
S
L
H
S
----
S
I
E
E
V
M
A
E
V
D
I
L
Y
M
T
R
V
Q
K
E
R
L
D
P
S
-----
E
Y
A
N
V
K
A
Q
F
V
L
R
A
S
D
L
H
N
A
K
A
N
M
K
V
L
H
P
L
P
--
R
V
D
E
I
A
T
D
V
D
K
T
P
H
A
W
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
A
L
V
L
------
120
PsiBlast_CBE
66.25
33%
-3
- C7 -
-
1TUG
1
PYRB_ECOLI
A:
[8-304]
---------
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
L
K
A
N
P
Q
P
E
L
L
K
H
K
V
I
A
S
C
F
F
A
A
S
T
R
T
R
L
S
F
E
T
S
M
H
R
L
G
A
S
V
V
G
F
-
S
D
S
A
N
T
--
S
L
G
K
K
G
E
T
L
A
D
T
I
S
V
I
S
T
Y
-
V
D
A
I
V
M
R
H
P
Q
E
-
G
A
-
A
R
-
L
A
T
E
F
S
-
G
N
V
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
Q
E
T
Q
G
R
L
D
N
L
H
V
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
D
G
N
R
F
Y
F
I
A
P
D
A
L
--
A
M
-----
P
Q
Y
I
L
D
M
L
D
E
K
G
I
--
A
--------
W
S
L
H
S
----
S
I
E
E
V
M
A
E
V
D
I
L
Y
M
T
R
V
Q
K
E
R
L
D
P
S
-----
E
Y
A
N
V
K
A
Q
F
V
L
R
A
S
D
L
H
N
A
K
A
N
M
K
V
L
H
P
L
P
--
R
V
D
E
I
A
T
D
V
D
K
T
P
H
A
W
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
A
L
V
L
------
62
PsiBlast_CBE
66.07
33%
-1
- C7 -
-
4F04
1
PYRB_ECOLI
A:
[8-304]
---------
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
L
K
A
N
P
Q
P
E
L
L
K
H
K
V
I
A
S
C
F
F
E
A
S
T
R
T
R
L
S
F
E
T
S
M
H
R
L
G
A
S
V
V
G
F
-
S
DS
A
N
T
--
S
L
G
K
K
G
E
T
L
A
D
T
I
S
V
I
S
T
Y
-
V
D
A
I
V
M
R
H
P
Q
E
-
G
A
-
A
R
-
L
A
T
E
F
S
-
G
N
V
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
Q
E
T
Q
G
R
L
D
N
L
H
V
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
D
G
N
R
F
Y
F
I
A
P
D
A
L
--
A
M
-----
P
Q
Y
I
L
D
M
L
D
E
K
G
I
--
A
--------
W
S
L
H
S
----
S
I
E
E
V
M
A
E
V
D
I
L
Y
M
T
R
V
Q
K
E
R
L
D
P
S
-----
E
Y
A
N
V
K
A
Q
F
V
L
R
A
S
D
L
H
N
A
K
A
N
M
K
V
L
H
P
L
P
--
R
V
D
E
I
A
T
D
V
D
K
T
P
H
A
W
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
A
L
V
L
------
67
PsiBlast_CBE
66.04
33%
-3
- C7 -
-
2H3E
1
PYRB_ECOLI
C:
[8-304]
---------
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
L
K
A
N
P
Q
P
E
L
L
K
H
K
V
I
A
S
C
F
F
E
A
S
T
R
T
R
L
S
F
E
T
S
M
H
R
L
G
A
S
V
V
G
F
-
S
DS
A
N
T
--
S
L
G
K
K
G
E
T
L
A
D
T
I
S
V
I
S
T
Y
-
V
D
A
I
V
M
R
H
P
Q
E
-
G
A
-
A
R
-
L
A
T
E
F
S
-
G
N
V
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
Q
E
T
Q
G
R
L
D
N
L
H
V
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
D
G
N
R
F
Y
F
I
A
P
D
A
L
--
A
M
-----
P
Q
Y
ILDMLDEKG
I
--
A
--------
W
S
L
H
S
----
S
I
E
E
V
M
A
E
V
D
I
L
Y
M
T
R
V
Q
K
E
R
L
D
P
S
-----
E
Y
A
N
V
K
A
Q
F
V
L
R
A
S
D
L
H
N
A
K
A
N
M
K
V
L
H
P
L
P
--
R
V
D
E
I
A
T
D
V
D
K
T
P
H
A
W
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
A
L
V
L
------
110
PsiBlast_CBE
65.91
33%
1
- C7 -
-
2AT1
2
PYRB_ECOLI
C:
[8-304]
---------
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
L
K
A
N
P
Q
P
E
L
L
K
H
K
V
I
A
S
C
F
F
E
A
S
T
R
T
R
L
S
F
Q
T
S
M
H
R
L
G
A
S
V
V
G
F
-
S
DS
A
N
T
--
S
L
G
K
K
G
E
T
L
A
D
T
I
S
V
I
S
T
Y
-
V
D
A
I
V
M
R
H
P
Q
E
-
G
A
-
A
R
-
L
A
T
E
F
S
-
G
N
V
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
Q
Q
T
E
G
R
L
D
N
L
H
V
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
D
G
N
R
F
Y
F
I
A
P
D
A
L
--
A
M
-----
P
E
Y
ILDMLDEKG
I
--
A
--------
W
S
L
H
S
----
S
I
E
E
V
M
A
E
V
D
I
L
Y
M
T
R
V
Q
K
E
R
L
D
P
S
-----
E
Y
A
N
V
K
A
Q
F
V
L
R
A
S
D
L
H
N
A
K
A
N
M
K
V
L
H
P
L
P
--
R
V
D
E
I
A
T
D
V
D
K
T
P
H
A
W
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
A
L
V
L
------
52
PsiBlast_CBE
65.89
33%
-0
- C7 -
-
4KH0
1
?
C:
[8-304]
---------
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
L
K
A
N
P
Q
P
E
L
L
K
H
K
V
I
A
S
C
F
F
E
A
S
T
R
T
R
L
S
F
E
T
S
M
H
R
L
G
A
S
V
V
G
F
-
S
DS
A
N
T
--
S
L
G
K
K
G
E
T
L
A
D
T
I
S
V
I
S
T
Y
-
V
D
A
I
V
M
R
H
P
Q
E
-
G
A
-
A
R
-
L
A
T
E
F
S
-
G
N
V
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
Q
E
T
Q
G
R
L
D
N
L
H
V
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
D
G
N
R
F
Y
F
I
A
P
D
A
L
--
A
M
-----
P
Q
Y
ILDMLDEKG
I
--
A
--------
W
S
L
H
S
----
S
I
E
E
V
M
A
E
V
D
I
L
Y
M
T
R
V
Q
K
E
R
L
D
P
S
-----
E
Y
A
N
V
K
A
Q
F
V
L
R
A
S
D
L
H
N
A
K
A
N
M
K
V
L
H
P
L
P
--
R
V
D
E
I
A
T
D
V
D
K
T
P
H
A
W
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
A
L
V
L
------
111
PsiBlast_CBE
65.87
33%
-2
- C7 -
-
2AT1
2
PYRB_ECOLI
A:
[8-304]
---------
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
L
K
A
N
P
Q
P
E
L
L
K
H
K
V
I
A
S
C
F
F
E
A
S
T
R
T
R
L
S
F
Q
T
S
M
H
R
L
G
A
S
V
V
G
F
-
S
DS
A
N
T
--
S
L
G
K
K
G
E
T
L
A
D
T
I
S
V
I
S
T
Y
-
V
D
A
I
V
M
R
H
P
Q
E
-
G
A
-
A
R
-
L
A
T
E
F
S
-
G
N
V
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
Q
Q
T
E
G
R
L
D
N
L
H
V
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
D
G
N
R
F
Y
F
I
A
P
D
A
L
--
A
M
-----
P
E
Y
I
L
D
M
L
D
E
K
G
I
--
A
--------
W
S
L
H
S
----
S
I
E
E
V
M
A
E
V
D
I
L
Y
M
T
R
V
Q
K
E
R
L
D
P
S
-----
E
Y
A
N
V
K
A
Q
F
V
L
R
A
S
D
L
H
N
A
K
A
N
M
K
V
L
H
P
L
P
--
R
V
D
E
I
A
T
D
V
D
K
T
P
H
A
W
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
A
L
V
L
------
123
PsiBlast_CBE
65.56
33%
1
- C7 -
-
1TTH
1
PYRB_ECOLI
C:
[8-304]
---------
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
L
K
A
N
P
Q
P
E
L
L
K
H
K
V
I
A
S
C
F
F
A
A
S
T
R
T
R
L
S
F
E
T
S
M
H
R
L
G
A
S
V
V
G
F
-
S
DS
A
N
T
--
S
L
G
K
K
G
E
T
L
A
D
T
I
S
V
I
S
T
Y
-
V
D
A
I
V
M
R
H
P
Q
E
-
G
A
-
A
R
-
L
A
T
E
F
S
-
G
N
V
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
Q
E
T
Q
G
R
L
D
N
L
H
V
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
D
G
N
R
F
Y
F
I
A
P
D
A
L
--
A
M
-----
P
Q
Y
ILDMLDEKG
I
--
A
--------
W
S
L
H
S
----
S
I
E
E
V
M
A
E
V
D
I
L
Y
M
T
R
V
Q
K
E
R
L
D
P
S
-----
E
Y
A
N
V
K
A
Q
F
V
L
R
A
S
D
L
H
N
A
K
A
N
M
K
V
L
H
P
L
P
--
R
V
D
E
I
A
T
D
V
D
K
T
P
H
A
W
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
A
L
V
L
------
65
PsiBlast_CBE
65.56
33%
-2
- C7 -
-
2IPO
4
PYRB_ECOLI
C:
[8-304]
---------
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
L
K
A
N
P
Q
P
E
L
L
K
H
K
V
I
A
S
C
F
F
E
A
S
T
R
T
R
L
S
F
E
T
S
M
H
R
L
G
A
S
V
V
G
F
-
S
DS
A
N
T
--
S
L
G
K
K
G
E
T
L
A
D
T
I
S
V
I
S
T
Y
-
V
D
A
I
V
M
R
H
P
Q
E
-
G
A
-
A
R
-
L
A
T
E
F
S
-
G
N
V
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
Q
E
T
Q
G
R
L
D
N
L
H
V
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
D
G
N
R
F
Y
F
I
A
P
D
A
L
--
A
M
-----
P
Q
Y
ILDMLDEKG
I
--
A
--------
W
S
L
H
S
----
S
I
E
E
V
M
A
E
V
D
I
L
Y
M
T
R
V
Q
K
E
R
L
D
P
S
-----
E
Y
A
N
V
K
A
Q
F
V
L
R
A
S
D
L
H
N
A
K
A
N
M
K
V
L
H
P
L
P
--
R
V
D
E
I
A
T
D
V
D
K
T
P
H
A
W
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
A
L
V
L
------
105
PsiBlast_CBE
65.51
33%
3
- C7 -
-
8AT1
2
PYRB_ECOLI
A:
[8-304]
---------
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
L
K
A
N
P
Q
P
E
L
L
K
H
K
V
I
A
S
C
F
F
E
A
S
T
R
T
R
L
S
F
Q
T
S
M
H
R
L
G
A
S
V
V
G
F
-
S
DS
A
N
T
--
S
L
G
K
K
G
E
T
L
A
D
T
I
S
V
I
S
T
Y
-
V
D
A
I
V
M
R
H
P
Q
E
-
G
A
-
A
R
-
L
A
T
E
F
S
-
G
N
V
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
Q
Q
T
E
G
R
L
D
N
L
H
V
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
D
G
N
R
F
Y
F
I
A
P
D
A
L
--
A
M
-----
P
E
Y
I
L
D
M
L
D
E
K
G
I
--
A
--------
W
S
L
H
S
----
S
I
E
E
V
M
A
E
V
D
I
L
Y
M
T
R
V
Q
K
E
R
L
D
P
S
-----
E
Y
A
N
V
K
A
Q
F
V
L
R
A
S
D
L
H
N
A
K
A
N
M
K
V
L
H
P
L
P
--
R
V
D
E
I
A
T
D
V
D
K
T
P
H
A
W
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
A
L
V
L
------
68
PsiBlast_CBE
65.34
33%
1
- C7 -
-
2H3E
1
PYRB_ECOLI
A:
[8-304]
---------
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
L
K
A
N
P
Q
P
E
L
L
K
H
K
V
I
A
S
C
F
F
E
A
S
T
R
T
R
L
S
F
E
T
S
M
H
R
L
G
A
S
V
V
G
F
-
S
DS
A
N
T
--
S
L
G
K
K
G
E
T
L
A
D
T
I
S
V
I
S
T
Y
-
V
D
A
I
V
M
R
H
P
Q
E
-
G
A
-
A
R
-
L
A
T
E
F
S
-
G
N
V
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
Q
E
T
Q
G
R
L
D
N
L
H
V
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
D
G
N
R
F
Y
F
I
A
P
D
A
L
--
A
M
-----
P
Q
Y
I
L
D
M
L
D
E
K
G
I
--
A
--------
W
S
L
H
S
----
S
I
E
E
V
M
A
E
V
D
I
L
Y
M
T
R
V
Q
K
E
R
L
D
P
S
-----
E
Y
A
N
V
K
A
Q
F
V
L
R
A
S
D
L
H
N
A
K
A
N
M
K
V
L
H
P
L
P
--
R
V
D
E
I
A
T
D
V
D
K
T
P
H
A
W
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
A
L
V
L
------
50
PsiBlast_CBE
65.28
33%
-2
- C7 -
-
4KH1
1
?
C:
[8-304]
---------
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
L
K
A
N
P
Q
P
E
L
L
K
H
K
V
I
A
S
C
F
F
E
A
S
T
R
T
R
L
S
F
E
T
S
M
H
R
L
G
A
S
V
V
G
F
-
S
DS
A
N
T
--
S
L
G
K
K
G
E
T
L
A
D
T
I
S
V
I
S
T
Y
-
V
D
A
I
V
M
R
H
P
Q
E
-
G
A
-
A
R
-
L
A
T
E
F
S
-
G
N
V
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
Q
E
T
Q
G
R
L
D
N
L
H
V
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
D
G
N
R
F
Y
F
I
A
P
D
A
L
--
A
M
-----
P
Q
Y
ILDMLDEKG
I
--
A
--------
W
S
L
H
S
----
S
I
E
E
V
M
A
E
V
D
I
L
Y
M
T
R
V
Q
K
E
R
L
D
P
S
-----
E
Y
A
N
V
K
A
Q
F
V
L
R
A
S
D
L
H
N
A
K
A
N
M
K
V
L
H
P
L
P
--
R
V
D
E
I
A
T
D
V
D
K
T
P
H
A
W
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
A
L
V
L
------
93
PsiBlast_CBE
65.27
33%
2
- C7 -
-
1D09
1
PYRB_ECOLI
C:
[8-304]
---------
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
L
K
A
N
P
Q
P
E
L
L
K
H
K
V
I
A
S
C
F
F
E
A
S
T
R
T
R
L
S
F
E
T
S
M
H
R
L
G
A
S
V
V
G
F
-
S
DS
A
N
T
--
S
L
G
K
K
G
E
T
L
A
D
T
I
S
V
I
S
T
Y
-
V
D
A
I
V
M
R
H
P
Q
E
-
G
A
-
A
R
-
L
A
T
E
F
S
-
G
N
V
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
Q
Q
T
Q
G
R
L
D
N
L
H
V
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
D
G
N
R
F
Y
F
I
A
P
D
A
L
--
A
M
-----
P
E
Y
ILDMLDEKG
I
--
A
--------
W
S
L
H
S
----
S
I
E
E
V
M
A
E
V
D
I
L
Y
M
T
R
V
Q
K
E
R
L
D
P
S
-----
E
Y
A
N
V
K
A
Q
F
V
L
R
A
S
D
L
H
N
A
K
A
N
M
K
V
L
H
P
L
P
--
R
V
D
E
I
A
T
D
V
D
K
T
P
H
A
W
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
A
L
V
L
------
124
PsiBlast_CBE
65.19
33%
1
- C7 -
-
1TTH
1
PYRB_ECOLI
A:
[8-304]
---------
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
L
K
A
N
P
Q
P
E
L
L
K
H
K
V
I
A
S
C
F
F
A
A
S
T
R
T
R
L
S
F
E
T
S
M
H
R
L
G
A
S
V
V
G
F
-
S
DS
A
N
T
--
S
L
G
K
K
G
E
T
L
A
D
T
I
S
V
I
S
T
Y
-
V
D
A
I
V
M
R
H
P
Q
E
-
G
A
-
A
R
-
L
A
T
E
F
S
-
G
N
V
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
Q
E
T
Q
G
R
L
D
N
L
H
V
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
D
G
N
R
F
Y
F
I
A
P
D
A
L
--
A
M
-----
P
Q
Y
I
L
D
M
L
D
E
K
G
I
--
A
--------
W
S
L
H
S
----
S
I
E
E
V
M
A
E
V
D
I
L
Y
M
T
R
V
Q
K
E
R
L
D
P
S
-----
E
Y
A
N
V
K
A
Q
F
V
L
R
A
S
D
L
H
N
A
K
A
N
M
K
V
L
H
P
L
P
--
R
V
D
E
I
A
T
D
V
D
K
T
P
H
A
W
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
A
L
V
L
------
56
PsiBlast_CBE
65.12
33%
-1
- C7 -
-
4KGX
1
?
C:
[8-304]
---------
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
L
K
A
N
P
Q
P
E
L
L
K
H
K
V
I
A
S
C
F
F
E
A
S
T
R
T
R
L
S
F
E
T
S
M
H
R
L
G
A
S
V
V
G
F
-
S
DS
A
N
T
--
S
L
G
K
K
G
E
T
L
A
D
T
I
S
V
I
S
T
Y
-
V
D
A
I
V
M
R
H
P
Q
E
-
G
A
-
A
R
-
L
A
T
E
F
S
-
G
N
V
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
Q
E
T
Q
G
R
L
D
N
L
H
V
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
D
G
N
R
F
Y
F
I
A
P
D
A
L
--
A
M
-----
P
Q
Y
ILDMLDEKG
I
--
A
--------
W
S
L
H
S
----
S
I
E
E
V
M
A
E
V
D
I
L
Y
M
T
R
V
Q
K
E
R
L
D
P
S
-----
E
Y
A
N
V
K
A
Q
F
V
L
R
A
S
D
L
H
N
A
K
A
N
M
K
V
L
H
P
L
P
--
R
V
D
E
I
A
T
D
V
D
K
T
P
H
A
W
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
A
L
V
L
------
66
PsiBlast_CBE
64.97
33%
-3
- C7 -
-
2IPO
2
PYRB_ECOLI
A:
[8-304]
---------
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
L
K
A
N
P
Q
P
E
L
L
K
H
K
V
I
A
S
C
F
F
E
A
S
T
R
T
R
L
S
F
E
T
S
M
H
R
L
G
A
S
V
V
G
F
-
S
DS
A
N
T
--
S
L
G
K
K
G
E
T
L
A
D
T
I
S
V
I
S
T
Y
-
V
D
A
I
V
M
R
H
P
Q
E
-
G
A
-
A
R
-
L
A
T
E
F
S
-
G
N
V
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
Q
E
T
Q
G
R
L
D
N
L
H
V
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
D
G
N
R
F
Y
F
I
A
P
D
A
L
--
A
M
-----
P
Q
Y
I
L
D
M
L
D
E
K
G
I
--
A
--------
W
S
L
H
S
----
S
I
E
E
V
M
A
E
V
D
I
L
Y
M
T
R
V
Q
K
E
R
L
D
P
S
-----
E
Y
A
N
V
K
A
Q
F
V
L
R
A
S
D
L
H
N
A
K
A
N
M
K
V
L
H
P
L
P
--
R
V
D
E
I
A
T
D
V
D
K
T
P
H
A
W
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
A
L
V
L
------
118
PsiBlast_CBE
63.12
33%
-8
- C7 -
-
2A0F
1
PYRB_ECOLI
A:
[8-304]
---------
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
L
K
A
N
P
Q
P
E
L
L
K
H
K
V
I
A
S
C
F
F
E
A
S
T
R
T
R
L
S
F
E
T
S
M
H
R
L
G
A
S
V
V
G
F
-
S
DS
A
N
T
--
S
L
G
K
K
G
E
T
L
A
D
T
I
S
V
I
S
T
Y
-
V
D
A
I
V
M
R
H
P
Q
E
-
G
A
-
A
R
-
L
A
T
E
F
S
-
G
N
V
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
Q
E
T
Q
G
R
L
D
N
L
H
V
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
D
G
N
R
F
Y
F
I
A
P
D
A
L
--
A
M
-----
P
Q
Y
I
L
D
M
L
D
E
K
G
I
--
A
--------
W
S
L
H
S
----
S
I
E
E
V
M
A
E
V
D
I
L
Y
M
T
R
V
Q
K
E
R
L
---
A
P
S
--
E
Y
A
N
V
K
A
Q
F
V
L
R
A
S
D
L
H
N
A
K
A
N
M
K
V
L
H
P
L
P
--
R
V
D
E
I
A
T
D
V
D
K
T
P
H
A
W
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
A
L
V
L
------
12
PsiBlast_PDB
57.96
37%
14
- C7 -
-
1ML4
1
PYRB_PYRAB
A:
[32-306]
------------------------------
E
L
K
E
K
G
Q
L
E
Y
A
K
G
K
I
L
A
T
L
F
F
E
P
S
T
R
T
R
L
S
F
E
S
A
M
H
R
L
G
G
A
V
I
G
F
A
E
--
A
S
T
--
S
S
V
K
K
G
E
S
L
R
D
T
I
K
T
V
E
Q
Y
-
C
D
V
I
V
I
R
H
P
K
E
-
G
A
-
A
R
--
L
A
A
E
V
-
A
E
V
P
V
I
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
Y
T
I
K
K
E
F
G
R
I
D
G
L
K
I
G
L
L
G
D
L
K
Y
G
R
T
V
H
S
L
A
E
A
L
T
F
Y
-
D
V
E
L
Y
L
I
S
P
E
L
L
--
R
M
P
R
H
I
V
E
E
L
---------
R
--
E
--------
K
G
M
K
V
V
E
T
T
T
L
E
D
V
I
G
K
L
D
V
L
Y
V
T
R
I
Q
K
E
R
F
P
D
E
Q
E
Y
L
K
V
K
G
S
Y
Q
V
N
L
K
V
L
E
K
A
K
D
E
L
R
----
I
M
H
P
L
P
--
R
V
D
E
I
H
P
E
V
D
N
T
K
H
A
I
Y
F
R
Q
V
F
N
G
V
P
V
R
M
A
L
L
A
L
V
L
G
-----