@TOME V2.3
(Mar 2018)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : spr1202: (2018-01-07 )
MIGGKNMDKDYILKVKGLYHQFLLGNNKTLQVLKNVSLSASRGEFISILGISGSGKSTLLKCISSLLEPTSGEVILNGINPYKIRNAKLSSIRRNEVSFIFQAYNLIPSLPVIENIALPLRLSQKKLTIKNVENLLKRMKFNAGLNDFVGTLSGGEQQKVAIARAVIADSDIIFADEPTGALDSVSREVIFELLRELVGAGKCVIMVTHDIELASKTDRALILKDGKIFKELHRPSGEELYKILEVQSTTEE
Atome Classification :
(47 SA)
.........10........20........30........40........50........60........70.......--.80.....-------...90..--......100-.......110.-----...-..-.-120----.---.-----.--.--.-----..----..130.-.......140..--.-..----..150---........160.......170.......180.-......190...---....200........210....-.-..220.......-----230-----........240.......250-------------------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MIGGKNMD
K
D
Y
I
L
K
V
K
G
L
Y
H
Q
F
LLGNN
K
T
L
Q
V
L
K
NVSLSASRG
E
F
I
S
I
L
GISGS
G
K
S
T
L
L
K
C
I
S
S
L
LEPTSG
E
V
I
L
NG--INP
Y
K
I
RN-------
A
K
L
S
S
I
R
--
R
N
E
V
S
F
I
F
Q
-
A
Y
NLIPSL
P
V
I
-----
E
NI-AL-
P
-
L
------R---L-----S--Q--K-----K
L
----
T
I
K
-
N
V
-
E
N
L
L
K
R
M
KFNAG--
L
-
N
D
----
F
V
G
T----LSGGE
Q
Q
K
V
A
I
A
R
A
VIADS
D
I
I
F
ADEPTG
A
L
D
-
S
V
S
R
E
V
I
F
E
L
L
R
---
E
L
VGA-G
K
C
V
I
M
V
T
H
D
I
ELASK-T-
D
R
A
L
I
LKD
G
K
I
F
-----
K
E
------
L
HRP
S
G
E
E
L
Y
K
I
L
E
VQSTTEE-------------------------------------------------------------------------------------------
7
PsiBlast_PDB
80.79
35%
0
- C- -
-
5NIL
-
?
J:
[4-242]
-----------
L
L
E
L
K
D
I
R
R
S
Y
P
A
G
D
E
Q
-
V
E
V
L
K
G
I
S
L
D
I
Y
A
G
E
M
V
A
I
V
G
A
S
G
S
G
K
S
T
L
M
N
I
L
G
C
L
D
K
A
T
S
G
T
Y
R
V
A
G
--
Q
D
V
A
T
L
D
A
-------
D
A
L
A
Q
L
R
--
R
E
H
F
G
F
I
F
Q
-
R
Y
H
L
L
S
H
L
T
A
E
-----
Q
N
V
-
E
V
-
P
-
A
------
V
---
Y
-----
A
GL
E
--
R
-----
K
Q
----
R
L
L
-
R
A
-
Q
E
L
L
Q
R
L
G
L
E
D
R
--
T
-
E
Y
----
Y
P
A
Q
----
L
S
G
G
Q
Q
Q
R
V
S
I
A
R
A
L
M
N
G
G
Q
V
I
L
A
D
E
P
T
G
A
L
D
-
S
H
S
G
E
E
V
M
A
I
L
H
---
Q
L
R
D
R
-
G
H
T
V
I
I
V
T
H
D
P
Q
V
A
A
Q
-
A
-
E
R
V
I
E
I
R
D
G
E
I
V
-----
R
-----------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
80.79
35%
0
- C- -
-
5NIK
-
?
J:
[4-242]
-----------
L
L
E
L
K
D
I
R
R
S
Y
P
A
G
D
E
Q
-
V
E
V
L
K
G
I
S
L
D
I
Y
A
G
E
M
V
A
I
V
G
A
S
G
S
G
K
S
T
L
M
N
I
L
G
C
L
D
K
A
T
S
G
T
Y
R
V
A
G
--
Q
D
V
A
T
L
D
A
-------
D
A
L
A
Q
L
R
--
R
E
H
F
G
F
I
F
Q
-
R
Y
H
L
L
S
H
L
T
A
E
-----
Q
N
V
-
E
V
-
P
-
A
------
V
---
Y
-----
A
GL
E
--
R
-----
K
Q
----
R
L
L
-
R
A
-
Q
E
L
L
Q
R
L
G
L
E
D
R
--
T
-
E
Y
----
Y
P
A
Q
----
L
S
G
G
Q
Q
Q
R
V
S
I
A
R
A
L
M
N
G
G
Q
V
I
L
A
D
E
P
T
G
A
L
D
-
S
H
S
G
E
E
V
M
A
I
L
H
---
Q
L
R
D
R
-
G
H
T
V
I
I
V
T
H
D
P
Q
V
A
A
Q
-
A
-
E
R
V
I
E
I
R
D
G
E
I
V
-----
R
-----------------------------------------------------------------------------------------------------------------------
148
Fugue
75.06
30%
-46
- C1 -
-
3TUZ
1
METN_ECOLI
H:
[23-362]
----------
H
M
I
K
L
S
N
I
T
K
V
F
H
Q
G
T
-
R
T
I
Q
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
T
E
G
S
V
L
V
D
G
--
Q
E
L
T
T
L
S
E
-------
S
E
L
T
K
A
R
--
R
Q
-
I
G
M
I
F
Q
-
H
F
N
L
L
S
S
R
T
V
F
-----
G
N
V
-
A
L
-
P
-
L
------
E
---
L
-----
D
NT
P
--
K
-----
D
E
----
V
K
R
-
R
V
-
T
E
L
L
S
L
V
G
L
G
D
K
--
H
-
D
S
----
Y
P
S
N
----
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
-
P
A
T
T
R
S
I
L
E
L
L
K
---
D
I
N
R
R
L
G
L
T
I
L
L
I
T
H
E
M
D
V
V
K
R
I
C
-
D
C
V
A
V
I
S
N
G
E
L
I
EQDTV
S
E
------
V
F
S
H
P
K
T
P
L
A
Q
K
F
I
Q
S
T
L
H
L
D
IPEDYQERLQAEPFTDCVPMLRLEFTGQSVDAPLLSETARRFNVNNNIISAQMDYAGGVKFGIMLTEMHGTQQDTQAAIAWLQEHHVKVEV
5
PsiBlast_PDB
74.73
42%
-23
- C1 -
-
2PCL
5
LOLD_AQUAE
A:
[18-223]
------------------------------
E
I
L
K
G
I
S
L
S
V
K
K
G
E
F
V
S
I
I
G
A
S
G
S
G
K
S
T
L
L
Y
I
L
G
L
L
D
A
P
T
E
G
K
V
F
L
E
G
--
K
E
V
D
Y
T
N
E
-------
K
E
L
S
L
L
R
--
N
R
K
L
G
F
V
F
Q
-
F
H
Y
L
I
P
E
L
T
A
L
-----
E
N
V
-
I
V
-
P
M
L
------
K
---
M
-----
G
--
K
--
P
-----
K
K
----
E
A
K
-
E
R
G
E
Y
L
L
S
E
L
G
L
G
D
K
--
L
-
S
R
----
K
P
Y
E
----
L
S
G
G
E
Q
Q
R
V
A
I
A
R
A
L
A
N
E
P
I
L
L
F
A
D
E
P
T
G
N
L
D
-
S
A
N
T
K
R
V
M
D
I
F
L
---
K
I
N
E
G
-
G
T
S
I
V
M
V
T
H
E
R
E
L
A
E
L
-
T
-
H
R
T
L
E
M
K
D
G
K
V
V
-----
G
E
------
I
T
R
-------------------------------------------------------------------------------------------------------------
25
PsiBlast_CBE
73.16
39%
-35
- C1 -
-
4YMU
1
?
A:
[10-217]
-------------------------
N
F
G
S
L
E
V
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
K
G
E
V
F
I
D
G
--
V
---
K
I
N
N
-------
G
K
V
N
I
N
K
V
-
R
Q
K
V
G
M
V
F
Q
-
H
F
N
L
F
P
H
L
T
A
I
-----
E
N
I
-
T
L
A
P
-
V
------
K
---
V
-----------
K
-----
K
M
----
N
K
K
-
E
A
-
E
E
L
A
V
D
L
L
A
K
V
G
--
L
-
L
D
KKDQ
Y
P
I
K
----
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
-
P
E
M
V
K
E
V
L
N
V
M
K
---
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
-
V
G
D
R
V
I
F
M
D
D
G
V
I
V
-----
E
E
----------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
73.14
42%
-25
- C1 -
-
2PCJ
-
LOLD_AQUAE
A:
[18-223]
------------------------------
E
I
L
K
G
I
S
L
S
V
K
K
G
E
F
V
S
I
I
G
A
S
G
S
G
K
S
T
L
L
Y
I
L
G
L
L
D
A
P
T
E
G
K
V
F
L
E
G
--
K
E
V
D
Y
T
N
E
-------
K
E
L
S
L
L
R
--
N
R
K
L
G
F
V
F
Q
-
F
H
Y
L
I
P
E
L
T
A
L
-----
E
N
V
-
I
V
-
P
M
L
------
K
---
M
-----
G
--
K
--
P
-----
K
K
----
E
A
K
-
E
R
G
E
Y
L
L
S
E
L
G
L
G
D
K
--
L
-
S
R
----
K
P
Y
E
----
L
S
G
G
E
Q
Q
R
V
A
I
A
R
A
L
A
N
E
P
I
L
L
F
A
D
E
P
T
G
N
L
D
-
S
A
N
T
K
R
V
M
D
I
F
L
---
K
I
N
E
G
-
G
T
S
I
V
M
V
T
H
E
R
E
L
A
E
L
-
T
-
H
R
T
L
E
M
K
D
G
K
V
V
-----
G
E
------
I
T
R
-------------------------------------------------------------------------------------------------------------
21
PsiBlast_CBE
73.04
41%
-33
- C1 -
-
1L2T
3
Y796_METJA
B:
[1-226]
-----------
M
I
K
L
K
N
V
T
K
T
Y
K
M
G
E
-
E
I
I
Y
A
L
K
N
V
N
L
N
I
K
E
G
E
F
V
S
I
M
G
P
S
G
S
G
K
S
T
M
L
N
I
I
G
C
L
D
K
P
T
E
G
E
V
Y
I
D
N
--
I
K
T
N
D
L
D
D
-------
D
E
L
T
K
I
R
--
R
D
K
I
G
F
V
F
Q
-
Q
F
N
L
I
P
L
L
T
A
L
-----
E
N
V
-
E
L
-
P
-
L
IFKYRG
A
---
M
-----
S
--
G
--
E
-----
E
R
----
R
K
R
-
A
L
-
E
C
L
K
M
A
E
L
E
E
R
F
--
A
-
N
H
----
K
P
N
Q
----
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
N
N
P
P
I
I
L
A
D
Q
P
T
G
A
L
D
-
S
K
T
G
E
K
I
M
Q
L
L
K
---
K
L
N
E
E
D
G
K
T
V
V
V
V
T
H
D
I
N
V
A
R
F
-
G
-
E
R
I
I
Y
L
K
D
G
E
V
E
-----
R
E
----------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
71.71
42%
-18
- C1 -
-
1F3O
1
Y796_METJA
A:
[2-226]
------------
I
K
L
K
N
V
T
K
T
Y
K
M
G
E
-
E
I
I
Y
A
L
K
N
V
N
L
N
I
K
E
G
E
F
V
S
I
M
G
P
S
G
S
G
K
S
T
M
L
N
I
I
G
C
L
D
K
P
T
E
G
E
V
Y
I
D
N
--
I
K
T
N
D
L
D
D
-------
D
E
L
T
K
I
R
--
R
D
K
I
G
F
V
F
Q
-
Q
F
N
L
I
P
L
L
T
A
L
-----
E
N
V
-
E
L
-
P
-
L
------
I
---
F
-----
K
--
Y
--
R
GAMS
G
E
E
----
R
R
K
-
R
A
-
L
E
C
L
K
M
A
E
L
E
E
R
--
F
A
N
H
----
K
P
N
Q
----
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
N
N
P
P
I
I
L
A
D
E
P
T
G
A
L
D
-
S
K
T
G
E
K
I
M
Q
L
L
K
---
K
L
N
E
E
D
G
K
T
V
V
V
V
T
H
D
I
N
V
A
R
F
-
G
-
E
R
I
I
Y
L
K
D
G
E
V
E
-----
R
E
----------------------------------------------------------------------------------------------------------------------
24
PsiBlast_CBE
71.60
39%
-29
- C1 -
-
4YMV
1
?
A:
[10-217]
-------------------------
N
F
G
S
L
E
V
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
K
G
E
V
F
I
D
G
--
V
---
K
I
N
N
-------
G
K
V
N
I
N
K
V
-
R
Q
K
V
G
M
V
F
Q
-
H
F
N
L
F
P
H
L
T
A
I
-----
E
N
I
-
T
L
A
P
-
V
------
K
---
V
-----------
K
-----
K
M
----
N
K
K
-
E
A
-
E
E
L
A
V
D
L
L
A
K
V
G
--
L
-
L
D
KKDQ
Y
P
I
K
----
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
-
P
E
M
V
K
E
V
L
N
V
M
K
---
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
-
V
G
D
R
V
I
F
M
D
D
G
V
I
V
-----
E
E
----------------------------------------------------------------------------------------------------------------------
63
PsiBlast_CBE
71.18
33%
-64
- C1 -
-
5X40
2
CBIO_RHOCB
A:
[16-233]
-----------
I
L
A
A
E
A
L
T
Y
A
F
P
G
G
----
V
K
A
L
D
D
L
S
L
A
V
P
K
G
E
S
L
A
I
L
G
P
N
G
A
G
K
S
T
L
L
L
H
L
N
G
T
L
R
P
Q
S
G
R
V
L
L
G
G
--
T
A
T
G
H
S
R
K
--------
D
L
T
G
W
R
--
R
R
-
V
G
L
V
L
Q
D
A
D
D
Q
L
F
A
T
T
V
F
-----
E
D
V
-
S
F
G
P
-
L
------
N
---
L
-----
G
--
L
--
S
-----
E
A
----
E
A
R
A
R
V
-
E
E
A
L
A
A
L
S
I
S
D
L
--
R
-
D
R
----
P
T
H
M
----
L
S
G
G
Q
K
R
R
V
A
I
A
G
A
V
A
M
R
P
E
V
L
L
L
D
Q
P
T
A
G
L
D
-
L
A
G
T
E
Q
L
L
T
L
L
R
---
G
L
R
A
A
-
G
M
T
L
V
F
S
T
H
D
V
E
L
A
A
A
L
A
-
D
R
V
A
L
F
R
T
G
R
V
L
-----
A
E
----------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
71.10
39%
-29
- C1 -
-
4YMU
1
?
J:
[10-217]
-------------------------
N
F
G
S
L
E
V
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
K
G
E
V
F
I
D
G
--
V
---
K
I
N
N
-------
G
K
V
N
I
N
K
V-
R
Q
K
V
G
M
V
F
Q
-
H
F
N
L
F
P
H
L
T
A
I
-----
E
N
I
-
T
L
A
P
-
V
------
K
---
V
-----------
K
-----
K
M
----
N
K
K
-
E
A
-
E
E
L
A
V
D
L
L
A
K
V
G
--
L
-
L
D
KKDQ
Y
P
I
K
----
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
-
P
E
M
V
K
E
V
L
N
V
M
K
---
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
-
V
G
D
R
V
I
F
M
D
D
G
V
I
V
-----
E
E
----------------------------------------------------------------------------------------------------------------------
22
PsiBlast_CBE
71.09
40%
-36
- C1 -
-
3TIF
4
Y796_METJA
B:
[1-226]
-----------
M
V
K
L
K
N
V
T
K
T
Y
K
M
G
E
-
E
I
I
Y
A
L
K
N
V
N
L
N
I
K
E
G
E
F
V
S
I
M
G
P
S
G
S
G
K
S
T
M
L
N
I
I
G
C
L
D
K
P
T
E
G
E
V
Y
I
D
N
--
I
K
T
N
D
L
D
D
-------
D
E
L
T
K
I
R
--
R
D
K
I
G
F
V
F
Q
-
Q
F
N
L
I
P
L
L
T
A
L
-----
E
N
V
-
E
L
-
P
-
L
IFKYRG
A
---
M
-----
S
--
G
--
E
-----
E
R
----
R
K
R
-
A
L
-
E
C
L
K
M
A
E
L
E
E
R
F
--
A
-
N
H
----
K
P
N
Q
----
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
N
N
P
P
I
I
L
A
D
Q
P
T
W
A
L
D
-
S
K
T
G
E
K
I
M
Q
L
L
K
---
K
L
N
E
E
D
G
K
T
V
V
V
V
T
H
D
I
N
V
A
R
F
-
G
-
E
R
I
I
Y
L
K
D
G
E
V
E
-----
R
E
----------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
70.91
39%
-26
- C1 -
-
4YMV
1
?
J:
[10-217]
-------------------------
N
F
G
S
L
E
V
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
K
G
E
V
F
I
D
G
--
V
---
K
I
N
N
-------
G
K
V
N
I
N
K
V-
R
Q
K
V
G
M
V
F
Q
-
H
F
N
L
F
P
H
L
T
A
I
-----
E
N
I
-
T
L
A
P
-
V
------
K
---
V
-----------
K
-----
K
M
----
N
K
K
-
E
A
-
E
E
L
A
V
D
L
L
A
K
V
G
--
L
-
L
D
KKDQ
Y
P
I
K
----
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
-
P
E
M
V
K
E
V
L
N
V
M
K
---
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
-
V
G
D
R
V
I
F
M
D
D
G
V
I
V
-----
E
E
----------------------------------------------------------------------------------------------------------------------
62
PsiBlast_CBE
70.90
33%
-65
* C1 *
-
5X40
2
CBIO_RHOCB
B:
[16-233]
-----------
I
L
A
A
E
A
L
T
Y
A
F
P
G
G
----
V
K
A
L
D
D
L
S
L
A
V
P
K
G
E
S
L
A
I
L
G
P
N
G
A
G
K
S
T
L
L
L
H
L
N
G
T
L
R
P
Q
S
G
R
V
L
L
G
G
--
T
A
T
G
H
S
R
K
--------
D
L
T
G
W
R
--
R
R
-
V
G
L
V
L
Q
D
A
D
D
Q
L
F
A
T
T
V
F
-----
E
D
V
-
S
F
G
P
-
L
------
N
---
L
-----
G
--
L
--
S
-----
E
A
----
E
A
R
A
R
V
-
E
E
A
L
A
A
L
S
I
S
D
L
--
R
-
D
R
----
P
T
H
M
----
L
S
G
G
Q
K
R
R
V
A
I
A
G
A
V
A
M
R
P
E
V
L
L
L
D
Q
P
T
A
G
L
D
-
L
A
G
T
E
Q
L
L
T
L
L
R
---
G
L
R
A
A
-
G
M
T
L
V
F
S
T
H
D
V
E
L
A
A
A
L
A
-
D
R
V
A
L
F
R
T
G
R
V
L
-----
A
E
----------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
70.50
39%
-29
- C1 -
-
4YMS
-
?
J:
[10-217]
-------------------------
N
F
G
S
L
E
V
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
K
G
E
V
F
I
D
G
--
V
---
K
I
N
N
-------
G
K
V
N
I
N
K
V-
R
Q
K
V
G
M
V
F
Q
-
H
F
N
L
F
P
H
L
T
A
I
-----
E
N
I
-
T
L
A
P
-
V
------
K
---
V
-----------
K
-----
K
M
----
N
K
K
-
E
A
-
E
E
L
A
V
D
L
L
A
K
V
G
--
L
-
L
D
KKDQ
Y
P
I
K
----
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
-
P
E
M
V
K
E
V
L
N
V
M
K
---
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
-
V
G
D
R
V
I
F
M
D
D
G
V
I
V
-----
E
E
----------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
69.89
41%
-27
- C1 -
-
1L2T
3
Y796_METJA
A:
[1-226]
-----------
M
I
K
L
K
N
V
T
K
T
Y
K
M
G
E
-
E
I
I
Y
A
L
K
N
V
N
L
N
I
K
E
G
E
F
V
S
I
M
G
P
S
G
S
G
K
S
T
M
L
N
I
I
G
C
L
D
K
P
T
E
G
E
V
Y
I
D
N
--
I
K
T
N
D
L
D
D
-------
D
E
L
T
K
I
R
--
R
D
K
I
G
F
V
F
Q
-
Q
F
N
L
I
P
L
L
T
A
L
-----
E
N
V
-
E
L
-
P
-
L
IFKYR
G
A
---
M
-----
S
--
G
--
E
-----
E
R
----
R
K
R
-
A
L
-
E
C
L
K
M
A
E
L
E
E
R
F
--
A
-
N
H
----
K
P
N
Q
----
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
N
N
P
P
I
I
L
A
D
Q
P
T
G
A
L
D
-
S
K
T
G
E
K
I
M
Q
L
L
K
---
K
L
N
E
E
D
G
K
T
V
V
V
V
T
H
D
I
N
V
A
R
F
-
G
-
E
R
I
I
Y
L
K
D
G
E
V
E
-----
R
E
----------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
69.40
39%
-28
- C1 -
-
4YMT
-
?
J:
[10-217]
-------------------------
N
F
G
S
L
E
V
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
K
G
E
V
F
I
D
G
--
V
---
K
I
N
N
-------
G
K
V
N
I
N
K
V-
R
Q
K
V
G
M
V
F
Q
-
H
F
N
L
F
P
H
L
T
A
I
-----
E
N
I
-
T
L
A
P
-
V
------
K
---
V
-----------
K
-----
K
M
----
N
K
K
-
E
A
-
E
E
L
A
V
D
L
L
A
K
V
G
--
L
-
L
D
KKDQ
Y
P
I
K
----
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
-
P
E
M
V
K
E
V
L
N
V
M
K
---
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
-
V
G
D
R
V
I
F
M
D
D
G
V
I
V
-----
E
E
----------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
69.10
39%
-30
- C1 -
-
4YMW
-
?
J:
[10-217]
-------------------------
N
F
G
S
L
E
V
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
K
G
E
V
F
I
D
G
--
V
---
K
I
N
N
-------
G
K
V
N
I
N
K
V-
R
Q
K
V
G
M
V
F
Q
-
H
F
N
L
F
P
H
L
T
A
I
-----
E
N
I
-
T
L
A
P
-
V
------
K
---
V
-----------
K
-----
K
M
----
N
K
K
-
E
A
-
E
E
L
A
V
D
L
L
A
K
V
G
--
L
-
L
D
KKDQ
Y
P
I
K
----
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
-
P
E
M
V
K
E
V
L
N
V
M
K
---
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
-
V
G
D
R
V
I
F
M
D
D
G
V
I
V
-----
E
E
----------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
68.97
35%
-47
- C1 -
-
4U02
-
?
A:
[4-226]
-----------
I
I
R
I
R
N
L
H
K
W
F
-----
G
P
L
H
V
L
K
G
I
H
L
E
V
A
P
G
E
K
L
V
I
I
G
P
S
G
S
G
K
S
T
L
I
R
T
I
N
R
L
E
D
F
Q
E
G
E
V
V
V
D
G
--
L
S
V
K
D
D
R
---------
A
L
R
E
I
R
--
R
-
E
V
G
M
V
F
Q
-
Q
F
N
L
F
P
H
M
T
V
L
-----
E
N
V
-
T
L
A
P
-
M
------
R
---
V
-----
R
--
R
WP
R
-----
E
K
----
A
E
K
-
K
A
-
L
E
L
L
E
R
V
G
I
L
D
Q
--
A
-
R
K
----
Y
P
A
Q
----
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
-
P
E
M
V
G
E
V
L
D
V
M
R
---
D
L
A
Q
G
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
A
-
D
R
V
V
F
M
D
G
G
Q
I
V
-----
E
E
-------
G
R
P
--
E
E
I
F
------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
68.81
40%
-35
- C1 -
-
3TIF
4
Y796_METJA
A:
[1-226]
-----------
M
V
K
L
K
N
V
T
K
T
Y
K
M
G
E
-
E
I
I
Y
A
L
K
N
V
N
L
N
I
K
E
G
E
F
V
S
I
M
G
P
S
G
S
G
K
S
T
M
L
N
I
I
G
C
L
D
K
P
T
E
G
E
V
Y
I
D
N
--
I
K
T
N
D
L
D
D
-------
D
E
L
T
K
I
R
--
R
D
K
I
G
F
V
F
Q
-
Q
F
N
L
I
P
L
L
T
A
L
-----
E
N
V
-
E
L
-
P
-
L
IFKYR
G
A
---
M
-----
S
--
G
--
E
-----
E
R
----
R
K
R
-
A
L
-
E
C
L
K
M
A
E
L
E
E
R
F
--
A
-
N
H
----
K
P
N
Q
----
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
N
N
P
P
I
I
L
A
D
Q
P
T
W
A
L
D
-
S
K
T
G
E
K
I
M
Q
L
L
K
---
K
L
N
E
E
D
G
K
T
V
V
V
V
T
H
D
I
N
V
A
R
F
-
G
-
E
R
I
I
Y
L
K
D
G
E
V
E
-----
R
E
----------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
66.31
35%
-48
- C1 -
-
4U00
1
?
A:
[4-226]
-----------
I
I
R
I
R
N
L
H
K
W
F
-----
G
P
L
H
V
L
K
G
I
H
L
E
V
A
P
G
E
K
L
V
I
I
G
P
S
G
S
G
K
S
T
L
I
R
T
I
N
R
L
E
D
F
Q
E
G
E
V
V
V
D
G
--
L
S
V
K
D
D
R
---------
A
L
R
E
I
R
--
R
-
E
V
G
M
V
F
Q
-
Q
F
N
L
F
P
H
M
T
V
L
-----
E
N
V
-
T
L
A
P
-
M
------
R
---
V
-----
R
--
R
WP
R
-----
E
K
----
A
E
K
-
K
A
-
L
E
L
L
E
R
V
G
I
L
D
Q
--
A
-
R
K
----
Y
P
A
Q
----
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
-
P
E
M
V
G
E
V
L
D
V
M
R
---
D
L
A
Q
G
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
A
-
D
R
V
V
F
M
D
G
G
Q
I
V
-----
E
E
-------
G
R
P
--
E
E
I
F
------------------------------------------------------------------------------------------------------
75
PsiBlast_CBE
63.43
34%
-16
- C1 -
-
3FVQ
2
FBPC_NEIG1
B:
[19-228]
-------------------------------
V
L
N
D
I
S
L
S
L
D
P
G
E
I
L
F
I
I
G
A
S
G
C
G
K
T
T
L
L
R
C
L
A
G
F
E
Q
P
D
S
G
E
I
S
L
S
G
--
K
T
I
F
S
-
K
N
-------
T
N
L
-
P
V
R
--
E
R
R
L
G
Y
L
V
Q
-
E
G
V
L
F
P
H
L
T
V
Y
-----
R
N
I
-
A
Y
-
G
-
L
GNGKG-
R
---
T
-----
A
--
Q
--
E
-----
R
-------
Q
-
R
I
-
E
A
M
L
E
L
T
G
I
S
E
L
--
A
-
G
R
----
Y
P
H
E
----
L
S
G
G
Q
Q
Q
R
A
A
L
A
R
A
L
A
P
D
P
E
L
I
L
L
D
E
P
F
S
A
L
D
E
Q
L
R
R
Q
I
R
E
D
M
I
A
---
A
L
R
A
N
-
G
K
S
A
V
F
V
S
H
D
R
E
E
A
L
Q
Y
A
-
D
R
I
A
V
M
K
Q
G
R
I
--------------
L
Q
T
A
S
P
H
E
L
Y
R
-----------------------------------------------------------------------------------------------------
44
PsiBlast_CBE
62.18
35%
-56
- C1 -
-
2OLK
1
?
D:
[36-240]
----------------------------
S
L
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
--
I
N
-
L
K
A
K
D
-------
T
N
L
N
K
V
R
---
E
E
V
G
M
V
F
Q
-
R
F
N
L
F
P
H
M
T
V
L
-----
N
N
I
-
T
L
A
P
-
M
------
K
---
V
RKW--
P
--
R
--
E
-----
K
A
----
E
A
K
-
A
M
-
E
-
L
L
D
K
V
G
L
K
D
K
--
A
-
H
A
----
Y
P
D
S
----
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
-
P
E
M
V
G
E
V
L
S
V
M
K
---
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
-
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
-----
E
E
----------------------------------------------------------------------------------------------------------------------
47
PsiBlast_CBE
62.11
35%
-59
- C1 -
-
2OLJ
2
?
B:
[36-240]
----------------------------
S
L
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
--
I
N
-
L
K
A
K
D
-------
T
N
L
N
K
V
R
---
E
E
V
G
M
V
F
Q
-
R
F
N
L
F
P
H
M
T
V
L
-----
N
N
I
-
T
L
A
P
-
M
------
K
---
V
RKW--
P
--
R
--
E
-----
K
A
----
E
A
K
-
A
M
-
E
-
L
L
D
K
V
G
L
K
D
K
--
A
-
H
A
----
Y
P
D
S
----
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
-
P
E
M
V
G
E
V
L
S
V
M
K
---
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
-
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
-----
E
E
----------------------------------------------------------------------------------------------------------------------
46
PsiBlast_CBE
61.31
35%
-57
- C1 -
-
2OLK
2
?
B:
[36-240]
----------------------------
S
L
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
--
I
N
-
L
K
A
K
D
-------
T
N
L
N
K
V
R
---
E
E
V
G
M
V
F
Q
-
R
F
N
L
F
P
H
M
T
V
L
-----
N
N
I
-
T
L
A
P
-
M
------
K
---
V
RKW--
P
--
R
--
E
-----
K
A
----
E
A
K
-
A
M
-
E
-
L
L
D
K
V
G
L
K
D
K
--
A
-
H
A
----
Y
P
D
S
----
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
-
P
E
M
V
G
E
V
L
S
V
M
K
---
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
-
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
-----
E
E
----------------------------------------------------------------------------------------------------------------------
35
PsiBlast_CBE
61.10
34%
-49
- C1 -
-
3C41
2
?
K:
[15-232]
----------------------------
S
L
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
--
I
N
-
L
K
A
K
D
-------
T
N
L
N
K
V
R
---
E
E
V
G
M
V
F
Q
-
R
F
N
L
F
P
H
M
T
V
L
-----
N
N
I
-
T
L
A
P
-
M
------
K
---
V
RKW--
P
--
R
--
E
-----
K
A
----
E
A
K
-
A
M
-
E
-
L
L
D
K
V
G
L
K
D
K
--
A
-
H
A
----
Y
P
D
S
----
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
-
P
E
M
V
G
E
V
L
S
V
M
K
---
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
-
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
-----
E
E
GKPEDL
F
D
R
P
Q
H
E
---------------------------------------------------------------------------------------------------------
39
PsiBlast_CBE
60.93
35%
-55
- C1 -
-
2Q0H
3
?
A:
[36-240]
----------------------------
S
L
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
--
I
N
-
L
K
A
K
D
-------
T
N
L
N
K
V
R
---
E
E
V
G
M
V
F
Q
-
R
F
N
L
F
P
H
M
T
V
L
-----
N
N
I
-
T
L
A
P
-
M
------
K
---
V
RKW--
P
--
R
--
E
-----
K
A
----
E
A
K
-
A
M
-
E
-
L
L
D
K
V
G
L
K
D
K
--
A
-
H
A
----
Y
P
D
S
----
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
-
P
E
M
V
G
E
V
L
S
V
M
K
---
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
-
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
-----
E
E
----------------------------------------------------------------------------------------------------------------------
76
PsiBlast_CBE
60.90
34%
-16
- C1 -
-
3FVQ
2
FBPC_NEIG1
A:
[19-233]
-------------------------------
V
L
N
D
I
S
L
S
L
D
P
G
E
I
L
F
I
I
G
A
S
G
C
G
K
T
T
L
L
R
C
L
A
G
F
E
Q
P
D
S
G
E
I
S
L
S
G
--
K
T
I
F
S
-
K
N
-------
T
N
L
-
P
V
R
--
E
R
R
L
G
Y
L
V
Q
-
E
G
V
L
F
P
H
L
T
V
Y
-----
R
N
I
-
A
Y
-
G
-
L
GNGKG-
R
---
T
-----
A
--
Q
--
E
-----
R
-------
Q
-
R
I
-
E
A
M
L
E
L
T
G
I
S
E
L
--
A
-
G
R
----
Y
P
H
E
----
L
S
G
G
Q
Q
Q
R
A
A
L
A
R
A
L
A
P
D
P
E
L
I
L
L
D
E
P
F
S
A
L
D
E
Q
L
R
R
Q
I
R
E
D
M
I
A
---
A
L
R
A
N
-
G
K
S
A
V
F
V
S
H
D
R
E
E
A
L
Q
Y
A
-
D
R
I
A
V
M
K
Q
G
R
I
--------------
L
Q
T
A
S
P
H
E
L
Y
R
-----------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
59.99
35%
-57
- C1 -
-
2OLJ
3
?
A:
[36-240]
----------------------------
S
L
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
--
I
N
-
L
K
A
K
D
-------
T
N
L
N
K
V
R
---
E
E
V
G
M
V
F
Q
-
R
F
N
L
F
P
H
M
T
V
L
-----
N
N
I
-
T
L
A
P
-
M
------
K
---
V
RKW--
P
--
R
--
E
-----
K
A
----
E
A
K
-
A
M
-
E
-
L
L
D
K
V
G
L
K
D
K
--
A
-
H
A
----
Y
P
D
S
----
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
-
P
E
M
V
G
E
V
L
S
V
M
K
---
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
-
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
-----
E
E
----------------------------------------------------------------------------------------------------------------------
37
PsiBlast_CBE
59.49
35%
-53
- C1 -
-
3C4J
2
?
A:
[36-240]
----------------------------
S
L
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
--
I
N
-
L
K
A
K
D
-------
T
N
L
N
K
V
R
---
E
E
V
G
M
V
F
Q
-
R
F
N
L
F
P
H
M
T
V
L
-----
N
N
I
-
T
L
A
P
-
M
------
K
---
V
RKW--
P
--
R
--
E
-----
K
A
----
E
A
K
-
A
M
-
E
-
L
L
D
K
V
G
L
K
D
K
--
A
-
H
A
----
Y
P
D
S
----
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
-
P
E
M
V
G
E
V
L
S
V
M
K
---
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
-
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
-----
E
E
----------------------------------------------------------------------------------------------------------------------
36
PsiBlast_CBE
58.83
35%
-50
- C1 -
-
3C4J
2
?
B:
[36-240]
----------------------------
S
L
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
--
I
N
-
L
K
A
K
D
-------
T
N
L
N
K
V
R
---
E
E
V
G
M
V
F
Q
-
R
F
N
L
F
P
H
M
T
V
L
-----
N
N
I
-
T
L
A
P
-
M
------
K
---
V
RKW--
P
--
R
--
E
-----
K
A
----
E
A
K
-
A
M
-
E
-
L
L
D
K
V
G
L
K
D
K
--
A
-
H
A
----
Y
P
D
S
----
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
-
P
E
M
V
G
E
V
L
S
V
M
K
---
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
-
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
-----
E
E
----------------------------------------------------------------------------------------------------------------------
65
PsiBlast_CBE
58.15
36%
-46
- C1 -
-
1B0U
1
HISP_SALTY
A:
[20-234]
------------------------------
E
V
L
K
G
V
S
L
Q
A
R
A
G
D
V
I
S
I
I
G
S
S
G
S
G
K
S
T
F
L
R
C
I
N
F
L
E
K
P
S
E
G
A
I
I
V
N
G
--
Q
N
I
N
L
V
R
D
KDGQLKV
A
D
K
N
Q
L
R
L
L
R
T
R
L
T
M
V
F
Q
-
H
F
N
L
W
S
H
M
T
V
L
-----
E
N
V
M
E
A
-
P
-
I
------
Q
VLG
L
-----
S
--
K
--
H
-----
D
A
----
R
E
R
-
A
L
-
K
Y
L
A
K
V
G
I
D
E
R
A
--
Q
-
G
K
----
Y
P
V
H
----
L
S
G
G
Q
Q
Q
R
V
S
I
A
R
A
L
A
M
E
P
D
V
L
L
F
D
E
P
T
S
A
L
D
-
P
---
E
L
V
G
E
V
L
R
I
M
Q
Q
L
A
E
E
-
G
K
T
M
V
V
V
T
H
E
M
G
F
A
R
H
V
S
-
S
H
V
I
F
L
H
Q
G
K
I
E
-----
E
E
----------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
57.98
35%
-56
- C1 -
-
2OLK
1
?
A:
[36-240]
----------------------------
S
L
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
--
I
N
-
L
K
A
K
D
-------
T
N
L
N
K
V
R
---
E
E
V
G
M
V
F
Q
-
R
F
N
L
F
P
H
M
T
V
L
-----
N
N
I
-
T
L
A
P
-
M
------
K
---
V
RKW--
P
--
R
--
E
-----
K
A
----
E
A
K
-
A
M
-
E
-
L
L
D
K
V
G
L
K
D
K
--
A
-
H
A
----
Y
P
D
S
----
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
-
P
E
M
V
G
E
V
L
S
V
M
K
---
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
-
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
-----
E
E
----------------------------------------------------------------------------------------------------------------------
45
PsiBlast_CBE
56.91
35%
-56
- C1 -
-
2OLK
1
?
C:
[36-240]
----------------------------
S
L
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
--
I
N
-
L
K
A
K
D
-------
T
N
L
N
K
V
R
---
E
E
V
G
M
V
F
Q
-
R
F
N
L
F
P
H
M
T
V
L
-----
N
N
I
-
T
L
A
P
-
M
------
K
---
V
RKW--
P
--
R
--
E
-----
K
A
----
E
A
K
-
A
M
-
E
-
L
L
D
K
V
G
L
K
D
K
--
A
-
H
A
----
Y
P
D
S
----
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
-
P
E
M
V
G
E
V
L
S
V
M
K
---
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
-
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
-----
E
E
----------------------------------------------------------------------------------------------------------------------
106
PsiBlast_CBE
56.75
32%
-40
- C1 -
-
2FFA
2
A:
[24-224]
-------------------------------
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
N
G
Q
V
L
I
D
G
-----
H
D
L
A
L
-------
A
D
P
N
W
L
R
--
R
-
Q
V
G
V
V
L
Q
-
D
-
N
V
L
L
N
R
S
I
I
-----
D
N
I
-
S
L
-
A
N
P
------
G
---
M
-----
S
--
V
--
E
-----
K
V
I
Y
A
A
K
L
A
-
G
A
-
H
D
F
I
S
E
L
R
--
E
G
--
Y
-
N
T
----
I
V
G
E
QGAG
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
-
Y
E
S
E
H
V
I
M
R
N
M
H
---
K
I
C
-
K
-
G
R
T
V
I
I
I
A
A
R
L
S
T
V
K
N
-
A
-
D
R
I
I
V
M
E
K
G
K
I
V
-----
E
Q
----------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
56.75
34%
-47
- C1 -
-
3C41
2
?
J:
[15-232]
----------------------------
S
L
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
--
I
N
-
L
K
A
K
D
-------
T
N
L
N
K
V
R
---
E
E
V
G
M
V
F
Q
-
R
F
N
L
F
P
H
M
T
V
L
-----
N
N
I
-
T
L
A
P
-
M
------
K
---
V
RKW--
P
--
R
--
E
-----
K
A
----
E
A
K
-
A
M
-
E
-
L
L
D
K
V
G
L
K
D
K
--
A
-
H
A
----
Y
P
D
S
----
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
-
P
E
M
V
G
E
V
L
S
V
M
K
---
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
-
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
-----
E
E
GKPEDL
F
D
R
P
Q
H
E
---------------------------------------------------------------------------------------------------------
110
PsiBlast_CBE
55.80
32%
-45
- C1 -
-
1XEF
2
HLYBP_ECOLX
A:
[18-218]
-------------------------------
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
N
G
Q
V
L
I
D
G
-----
H
D
L
A
L
-------
A
D
P
N
W
L
R
--
R
-
Q
V
G
V
V
L
Q
-
D
-
N
V
L
L
N
R
S
I
I
-----
D
N
I
-
S
L
-
A
N
P
------
G
---
M
-----
S
--
V
--
E
-----
K
V
I
Y
A
A
K
L
A
-
G
A
-
H
D
F
I
S
E
L
R
--
E
G
--
Y
-
N
T
----
I
V
G
E
QGAG
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
-
Y
E
S
E
H
V
I
M
R
N
M
H
---
K
I
C
-
K
-
G
R
T
V
I
I
I
A
A
R
L
S
T
V
K
N
-
A
-
D
R
I
I
V
M
E
K
G
K
I
V
-----
E
Q
----------------------------------------------------------------------------------------------------------------------
105
PsiBlast_CBE
55.51
32%
-37
- C1 -
-
2FGJ
2
HLYBP_ECOLX
A:
[24-224]
-------------------------------
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
N
G
Q
V
L
I
D
G
-----
H
D
L
A
L
-------
A
D
P
N
W
L
R
--
R
-
Q
V
G
V
V
L
Q
-
D
-
N
V
L
L
N
R
S
I
I
-----
D
N
I
-
S
L
-
A
N
P
------
G
---
M
-----
S
--
V
--
E
-----
K
V
I
Y
A
A
K
L
A
-
G
A
-
H
D
F
I
S
E
L
R
--
E
G
--
Y
-
N
T
----
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
-
Y
E
S
E
H
V
I
M
R
N
M
H
---
K
I
C
-
K
-
G
R
T
V
I
I
I
A
A
R
L
S
T
V
K
N
-
A
-
D
R
I
I
V
M
E
K
G
K
I
V
-----
E
Q
----------------------------------------------------------------------------------------------------------------------
67
PsiBlast_CBE
53.90
32%
-45
- C1 -
-
2FF7
1
A:
[24-224]
-------------------------------
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
N
G
Q
V
L
I
D
G
-----
H
D
L
A
L
-------
A
D
P
N
W
L
R
--
R
-
Q
V
G
V
V
L
Q
-
D
-
N
V
L
L
N
R
S
I
I
-----
D
N
I
-
S
L
-
A
N
P
------
G
---
M
-----
S
--
V
--
E
-----
K
V
I
Y
A
A
K
L
A
-
G
A
-
H
D
F
I
S
E
L
R
--
E
G
--
Y
-
N
T
----
I
V
G
E
QGAG
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
-
Y
E
S
E
H
V
I
M
R
N
M
H
---
K
I
C
-
K
-
G
R
T
V
I
I
I
A
H
R
L
S
T
V
K
N
-
A
-
D
R
I
I
V
M
E
K
G
K
I
V
-----
E
Q
----------------------------------------------------------------------------------------------------------------------
66
PsiBlast_CBE
53.69
32%
-45
- C1 -
-
2PMK
1
A:
[20-220]
-------------------------------
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
N
G
Q
V
L
I
D
G
-----
H
D
L
A
L
-------
A
D
P
N
W
L
R
--
R
-
Q
V
G
V
V
L
Q
-
D
-
N
V
L
L
N
R
S
I
I
-----
D
N
I
-
S
L
-
A
N
P
------
G
---
M
-----
S
--
V
--
E
-----
K
V
I
Y
A
A
K
L
A
-
G
A
-
H
D
F
I
S
E
L
R
--
E
G
--
Y
-
N
T
----
I
V
G
E
QGAG
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
-
Y
E
S
E
H
V
I
M
R
N
M
H
---
K
I
C
-
K
-
G
R
T
V
I
I
I
A
H
R
L
S
T
V
K
N
-
A
-
D
R
I
I
V
M
E
K
G
K
I
V
-----
E
Q
----------------------------------------------------------------------------------------------------------------------
71
PsiBlast_CBE
52.22
32%
-36
- C1 -
-
2FGK
2
HLYBP_ECOLX
C:
[24-224]
-------------------------------
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
N
G
Q
V
L
I
D
G
-----
H
D
L
A
L
-------
A
D
P
N
W
L
R
--
R
-
Q
V
G
V
V
L
Q
-
D
-
N
V
L
L
N
R
S
I
I
-----
D
N
I
-
S
L
-
A
N
P
------
G
---
M
-----
S
--
V
--
E
-----
K
V
IYAA
K
L
A
-
G
A
-
H
D
F
I
S
E
L
R
--
E
G
--
Y
-
N
T
----
I
V
G
E
QGAG
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
Q
A
T
S
A
L
D
-
Y
E
S
E
H
V
I
M
R
N
M
H
---
K
I
C
-
K
-
G
R
T
V
I
I
I
A
H
R
L
S
T
V
K
N
-
A
-
D
R
I
I
V
M
E
K
G
K
I
V
-----
E
Q
----------------------------------------------------------------------------------------------------------------------
72
PsiBlast_CBE
52.09
32%
-42
- C1 -
-
2FGK
2
HLYBP_ECOLX
B:
[24-224]
-------------------------------
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
N
G
Q
V
L
I
D
G
-----
H
D
L
A
L
-------
A
D
P
N
W
L
R
--
R
-
Q
V
G
V
V
L
Q
-
D
-
N
V
L
L
N
R
S
I
I
-----
D
N
I
-
S
L
-
A
N
P
------
G
---
M
-----
S
--
V
--
E
-----
K
V
IYAA
K
L
A
-
G
A
-
H
D
F
I
S
E
L
R
--
E
G
--
Y
-
N
T
----
I
V
G
E
QGAG
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
Q
A
T
S
A
L
D
-
Y
E
S
E
H
V
I
M
R
N
M
H
---
K
I
C
-
K
-
G
R
T
V
I
I
I
A
H
R
L
S
T
V
K
N
-
A
-
D
R
I
I
V
M
E
K
G
K
I
V
-----
E
Q
----------------------------------------------------------------------------------------------------------------------
102
PsiBlast_CBE
51.89
32%
-35
- C1 -
-
2FGJ
2
D:
[24-224]
-------------------------------
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
N
G
Q
V
L
I
D
G
-----
H
D
L
A
L
-------
A
D
P
N
W
L
R
--
R
-
Q
V
G
V
V
L
Q
-
D
-
N
V
L
L
N
R
S
I
I
-----
D
N
I
-
S
L
-
A
N
P
------
G
---
M
-----
S
--
V
--
E
-----
K
V
IYAA
K
L
A
-
G
A
-
H
D
F
I
S
E
L
R
--
E
G
--
Y
-
N
T
----
I
V
G
E
QGAG
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
-
Y
E
S
E
H
V
I
M
R
N
M
H
---
K
I
C
-
K
-
G
R
T
V
I
I
I
A
A
R
L
S
T
V
K
N
-
A
-
D
R
I
I
V
M
E
K
G
K
I
V
-----
E
Q
----------------------------------------------------------------------------------------------------------------------
73
PsiBlast_CBE
51.48
32%
-40
- C1 -
-
2FGK
2
HLYBP_ECOLX
A:
[24-224]
-------------------------------
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
N
G
Q
V
L
I
D
G
-----
H
D
L
A
L
-------
A
D
P
N
W
L
R
--
R
-
Q
V
G
V
V
L
Q
-
D
-
N
V
L
L
N
R
S
I
I
-----
D
N
I
-
S
L
-
A
N
P
------
G
---
M
-----
S
--
V
--
E
-----
K
V
I
Y
A
A
K
L
A
-
G
A
-
H
D
F
I
S
E
L
R
--
E
G
--
Y
-
N
T
----
I
V
G
E
QGAG
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
Q
A
T
S
A
L
D
-
Y
E
S
E
H
V
I
M
R
N
M
H
---
K
I
C
-
K
-
G
R
T
V
I
I
I
A
H
R
L
S
T
V
K
N
-
A
-
D
R
I
I
V
M
E
K
G
K
I
V
-----
E
Q
----------------------------------------------------------------------------------------------------------------------
70
PsiBlast_CBE
51.35
32%
-43
- C1 -
-
2FGK
2
D:
[24-224]
-------------------------------
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
N
G
Q
V
L
I
D
G
-----
H
D
L
A
L
-------
A
D
P
N
W
L
R
--
R
-
Q
V
G
V
V
L
Q
-
D
-
N
V
L
L
N
R
S
I
I
-----
D
N
I
-
S
L
-
A
N
P
------
G
---
M
-----
S
--
V
--
E
-----
K
V
IYAA
K
L
A
-
G
A
-
H
D
F
I
S
E
L
R
--
E
G
--
Y
-
N
T
----
I
V
G
E
QGAG
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
Q
A
T
S
A
L
D
-
Y
E
S
E
H
V
I
M
R
N
M
H
---
K
I
C
-
K
-
G
R
T
V
I
I
I
A
H
R
L
S
T
V
K
N
-
A
-
D
R
I
I
V
M
E
K
G
K
I
V
-----
E
Q
----------------------------------------------------------------------------------------------------------------------
118
PsiBlast_CBE
43.41
32%
-31
- C1 -
-
4HLU
1
ECFA1_THEMA
D:
[26-217]
-------------------------------
V
L
K
D
V
N
A
E
F
E
T
G
K
I
Y
V
V
V
G
K
N
G
S
G
K
T
T
L
L
K
I
L
A
G
L
L
-
A
A
A
G
E
I
F
L
D
G
SP
A
D
P
F
----------------
L
L
--
R
K
N
V
G
Y
V
F
Q
-
N
----
P
S
S
Q
I
I
GATVE
E
D
V
-
A
F
-
S
-
L
------
E
---
I
MGLDE
S
--
E
--
M
-----
R
K
----
R
I
K
-
K
V
-
L
E
L
V
G
L
S
G
L
A
A
A
DP
L
-
N
-------------
L
S
G
G
Q
K
Q
R
L
A
I
A
S
M
L
A
R
D
T
R
F
L
A
L
D
E
P
V
S
M
L
D
-
P
P
S
Q
R
E
I
F
Q
V
L
E
---
S
L
K
N
E
-
G
K
G
I
I
L
V
T
H
E
L
E
Y
L
D
D
-
M
-
D
F
I
L
H
I
S
N
G
T
I
------------------------------------------------------------------------------------------------------------------------------
119
PsiBlast_CBE
42.56
32%
-32
- C1 -
-
4HLU
1
ECFA1_THEMA
C:
[26-217]
-------------------------------
V
L
K
D
V
N
A
E
F
E
T
G
K
I
Y
V
V
V
G
K
N
G
S
G
K
T
T
L
L
K
I
L
A
G
L
L
-
A
A
A
G
E
I
F
L
D
G
SP
A
D
P
F
----------------
L
L
--
R
K
N
V
G
Y
V
F
Q
-
N
----
P
S
S
Q
I
I
GAT
V
E
E
D
V
-
A
F
-
S
-
L
------
E
---
I
MGLDE
S
--
E
--
M
-----
R
K
----
R
I
K
-
K
V
-
L
E
L
V
G
L
S
G
L
A
A
A
DP
L
-
N
-------------
L
S
G
G
Q
K
Q
R
L
A
I
A
S
M
L
A
R
D
T
R
F
L
A
L
D
E
P
V
S
M
L
D
-
P
P
S
Q
R
E
I
F
Q
V
L
E
---
S
L
K
N
E
-
G
K
G
I
I
L
V
T
H
E
L
E
Y
L
D
D
-
M
-
D
F
I
L
H
I
S
N
G
T
I
------------------------------------------------------------------------------------------------------------------------------