@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : spr1216: (2018-01-07 )
MKHLLSYFKPYIKESILAPLFKLLEAVFELLVPMVIAGIVDQSLPQGDQGHLWMQIGLLLIFAVIGVLVALIAQFYSAKAAVGSAKELTNDLYRHILSLPKDSRDRLTTSSLVTRLTSDTDQIQTGINQFLRLFLRAPIIVFGAIFMAYRISAELTFWFLVLVAILTIVIVGLSRLVNPFYSSLRKKTDQLVQETRQQLQGMRVIRAFGQEKRELQIFQTLNQVYARLQEKTGFWSSLLTPLTYLIVNGTLLVIIWQGYISIQGGVLSQGALIALINYLLQILVELVKLAMLINSLNQSYISVKRIEEVFVEAPEDIHSELEQKQATRDKVLQVQELTFTYPDAAQPSLRYISFDMTQGQILGIIGGTGSGKSSLVQLLLGLYPVDKGNIDLYQNGRSPLNLEQWRSWIAYVPQKVELFKGTIRSNLTLGFNQEVSDQELWQALEIAQAKDFVSEKEGLLDALVEAGGRNFSGGQKQRLSIARAVLRQAPFLILDDATSALDTITESKLLKAIRENFPNTSLILISQRTSTLQMADQILLLEKGELLAVGKHDDLMKSSQVYCEINASQHGKED
Atome Classification :
(20 SA)
---.........10---........20..-......30........40.......-------.--50.----...---..-.-.60........70........80........90........100.......110.......120.....-..130.......140.......-150.......160.......170.......180.......190...-------....200.......210.......220.......230.......-.240.......250.......260.-......270.......280.......290.......300.......310.......-----320.-.......330--........340..------.....350.......360.......370.......380.......390.......400.......410.......420.......430..---.....440.......450.-......460.......470.......480.......490........500.......510.......520.......530.......540.......550.......-560.......570..
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
---
M
K
H
L
L
S
Y
F
K
P
Y
---
I
K
E
S
I
L
A
P
L
F
K
L
-
L
E
A
V
F
E
L
L
V
P
M
V
I
A
G
I
V
DQSLPQGD-------Q--GH
L
----
W
M
Q
---
I
G
-
L
-
L
L
I
F
A
V
I
G
V
L
V
A
L
I
A
Q
F
Y
S
A
KAAVG
S
A
K
E
L
T
N
D
L
Y
R
H
I
LSLPKDSRDRL
T
T
S
S
L
V
T
R
LTS
D
T
D
Q
I
Q
T
G
I
-
N
Q
F
L
R
L
F
L
RA
P
I
I
V
F
G
A
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M
A
Y
-RIS
A
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L
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W
F
L
V
L
V
A
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L
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L
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R
Q
Q
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M
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Q
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K
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Y
A
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L
Q
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-KTG
F
W
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L
-
L
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P
L
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Y
L
IVN
G
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L
L
V
I
I
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Q
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IQ-GGVLSQ
G
A
L
I
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L
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N
Y
L
L
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L
V
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L
V
K
L
A
M
L
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L
N
Q
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Y
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K
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V
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VEA
P
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I
H
S
-----
E
-
L
E
-
Q
K
Q
A
T
R
D
K
V
---
L
Q
V
Q
E
L
T
F
TYPDA------AQP
S
L
R
Y
I
S
F
DMTQ
G
Q
I
L
G
I
IGGTGS
G
K
S
S
L
V
Q
L
L
L
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LYPVDKG
N
I
D
L
YQNGRSPL
N
L
E
Q
W
R
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W
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P
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K
V
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K
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T
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N
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LGFNQE---V
S
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Q
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L
W
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I
A
Q
A
K
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F
V
-
S
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L
L
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A
L
V
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AGGRNFSG
G
Q
K
Q
R
L
S
I
A
R
A
V
L
R
QA
P
-
F
L
I
LDD
A
T
S
A
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D
T
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K
L
L
K
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NFPNT
S
L
I
L
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SQRT
S
T
L
Q
M
A
D
Q
I
L
L
LEKG
E
L
L
A
VGK
H
D
D
L
MKSS-
Q
V
Y
C
E
IN
A
S
QHGKED
83
HHSearch
88.45
33%
-
- C1 -
-
4Q4H
-
?
A:
[2-569]
----
K
T
L
A
R
Y
L
K
P
Y
---
W
I
F
A
V
L
A
P
L
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-
V
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-------
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--
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L
V
----
L
K
T
---
G
I
-
L
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M
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G
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M
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K
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V
-------
R
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L
L
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V
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V
V
R
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L
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R
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I
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A
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-
A
L
P
L
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F
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N
M
G
M
I
A
V
L
W
F
G
G
V
L
-
V
R
N
N
Q
M
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I
G
S
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A
Y
T
N
Y
L
M
Q
I
M
F
S
L
M
M
I
G
N
I
L
N
F
I
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A
S
A
K
R
V
L
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V
L
N
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K
P
A
I
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A
-----
D
-
N
A
-
L
A
L
P
N
V
E
G
S
---
V
S
F
E
N
V
E
F
R
Y
F
E
N
------
T
D
P
V
L
S
G
V
N
F
S
V
K
P
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L
V
A
V
L
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T
G
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S
T
L
M
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L
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R
L
I
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P
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G
R
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V
D
E
L
D
V
R
T
V
K
L
K
D
L
R
G
H
I
S
A
V
P
Q
E
T
V
L
F
S
G
T
I
K
E
N
L
K
W
G
R
-
E
D
---
A
T
D
D
E
I
V
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A
A
K
I
A
Q
I
H
D
F
I
-
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L
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K
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A
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L
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L
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K
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A
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T
H
K
E
L
L
E
H
C
-
K
P
Y
R
E
I
Y
E
S
Q
F
----
3
PsiBlast_PDB
88.37
33%
-
- C1 -
-
4Q4H
-
?
A:
[2-569]
----
K
T
L
A
R
Y
L
K
P
Y
---
W
I
F
A
V
L
A
P
L
F
M
V
-
V
E
V
I
C
D
L
S
Q
P
T
L
L
A
R
I
V
D
E
G
I
A
R
G
D
-------
F
--
S
-
L
----
V
L
K
---
T
G
I
L
-
M
L
I
V
A
L
I
G
A
V
G
G
I
G
C
T
V
F
A
S
Y
A
S
Q
N
F
G
A
D
L
R
R
D
L
F
R
K
V
L
S
F
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I
S
N
V
N
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F
H
T
S
S
L
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R
L
T
N
D
V
T
Q
L
Q
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L
V
-
M
M
L
L
R
I
V
V
R
A
P
L
L
F
V
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G
I
V
M
A
V
-
S
I
N
V
K
L
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S
V
L
I
F
L
I
P
P
I
V
L
L
F
V
W
L
T
K
K
G
N
P
L
F
R
K
I
Q
E
S
T
D
E
V
N
R
V
V
-------
R
E
N
L
L
G
V
R
V
V
R
A
F
R
R
E
E
Y
E
N
E
N
F
R
K
A
N
E
S
L
R
R
S
I
I
-
S
A
F
S
L
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F
-
A
L
P
L
F
I
F
I
V
N
M
G
M
I
A
V
L
W
F
G
G
V
L
V
R
-
N
N
Q
M
E
I
G
S
I
M
A
Y
T
N
Y
L
M
Q
I
M
F
S
L
M
M
I
G
N
I
L
N
F
I
V
R
A
S
A
S
A
K
R
V
L
E
V
L
N
E
K
P
A
I
E
E
A
-----
D
-
N
A
-
L
A
L
P
N
V
E
G
S
---
V
S
F
E
N
V
E
F
R
Y
F
E
N
------
T
D
P
V
L
S
G
V
N
F
S
V
K
P
G
S
L
V
A
V
L
G
E
T
G
S
G
K
S
T
L
M
N
L
I
P
R
L
I
D
P
E
R
G
R
V
E
V
D
E
L
D
V
R
T
V
K
L
K
D
L
R
G
H
I
S
A
V
P
Q
E
T
V
L
F
S
G
T
I
K
E
N
L
K
W
G
-
R
E
D
---
A
T
D
D
E
I
V
E
A
A
K
I
A
Q
I
H
D
F
I
I
S
L
P
E
G
Y
-
D
S
R
V
E
R
G
G
R
N
F
S
G
G
Q
K
Q
R
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I
A
R
A
L
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K
P
K
-
V
L
I
L
D
D
C
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S
V
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P
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R
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L
K
R
Y
T
K
G
C
T
T
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I
I
T
Q
K
I
P
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A
L
L
A
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K
I
L
V
L
H
E
G
K
V
A
G
F
G
T
H
K
E
L
L
E
H
C
-
K
P
Y
R
E
I
Y
E
S
Q
F
----
1
PsiBlast_PDB
86.82
33%
-39
* C1 *
-
3QF4
1
?
A:
[12-579]
----
K
T
L
A
R
Y
L
K
P
Y
---
W
I
F
A
V
L
A
P
L
F
M
V
-
V
E
V
I
C
D
L
S
Q
P
T
L
L
A
R
I
V
D
E
G
I
A
R
G
D
-------
F
--
S
-
L
----
V
L
K
---
T
G
I
L
-
M
L
I
V
A
L
I
G
A
V
G
G
I
G
C
T
V
F
A
S
Y
A
S
Q
N
F
G
A
D
L
R
R
D
L
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K
V
L
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S
N
V
N
R
F
H
T
S
S
L
I
T
R
L
T
N
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T
Q
L
Q
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L
V
-
M
M
L
L
R
I
V
V
R
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L
L
F
V
G
G
I
V
M
A
V
-
S
I
N
V
K
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V
L
I
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L
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P
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L
L
F
V
W
L
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K
K
G
N
P
L
F
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K
I
Q
E
S
T
D
E
V
N
R
V
V
-------
R
E
N
L
L
G
V
R
V
V
R
A
F
R
R
E
E
Y
E
N
E
N
F
R
K
A
N
E
S
L
R
R
S
I
I
-
S
A
F
S
L
I
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F
-
A
L
P
L
F
I
F
I
V
N
M
G
M
I
A
V
L
W
F
G
G
V
L
V
R
-
N
N
Q
M
E
I
G
S
I
M
A
Y
T
N
Y
L
M
Q
I
M
F
S
L
M
M
I
G
N
I
L
N
F
I
V
R
A
S
A
S
A
K
R
V
L
E
V
L
N
E
K
P
A
I
E
E
A
-----
D
-
N
A
-
L
A
L
P
N
V
E
G
S
---
V
S
F
E
N
V
E
F
R
Y
F
E
N
------
T
D
P
V
L
S
G
V
N
F
S
V
K
P
G
S
L
V
A
V
L
G
E
T
G
S
G
K
S
T
L
M
N
L
I
P
R
L
I
D
P
E
R
G
R
V
E
V
D
E
L
D
V
R
T
V
K
L
K
D
L
R
G
H
I
S
A
V
P
Q
E
T
V
L
F
S
G
T
I
K
E
N
L
K
W
G
-
R
E
D
---
A
T
D
D
E
I
V
E
A
A
K
I
A
Q
I
H
D
F
I
I
S
L
P
E
G
Y
-
D
S
R
V
E
R
G
G
R
N
F
S
G
G
Q
K
Q
R
L
S
I
A
R
A
L
V
K
K
P
K
-
V
L
I
L
D
D
C
T
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S
V
D
P
I
T
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K
R
I
L
D
G
L
K
R
Y
T
K
G
C
T
T
F
I
I
T
Q
K
I
P
T
A
L
L
A
D
K
I
L
V
L
H
E
G
K
V
A
G
F
G
T
H
K
E
L
L
E
H
C
-
K
P
Y
R
E
I
Y
E
S
Q
F
----
4
PsiBlast_PDB
85.95
33%
-38
- C1 -
-
4Q4J
-
?
A:
[2-569]
----
K
T
L
A
R
Y
L
K
P
Y
---
W
I
F
A
V
L
A
P
L
F
M
V
-
V
E
V
I
S
D
L
S
Q
P
T
L
L
A
R
I
V
D
E
G
I
A
R
G
D
-------
F
--
S
-
L
----
V
L
K
---
T
G
I
L
-
M
L
I
V
A
L
I
G
A
V
G
G
I
G
S
T
V
F
A
S
Y
A
S
Q
N
F
G
A
D
L
R
R
D
L
F
R
K
V
L
S
F
S
I
S
N
V
N
R
F
H
T
S
S
L
I
T
R
L
T
N
D
V
T
Q
L
Q
N
L
V
-
M
M
L
L
R
I
V
V
R
A
P
L
L
F
V
G
G
I
V
M
A
V
-
S
I
N
V
K
L
S
S
V
L
I
F
L
I
P
P
I
V
L
L
F
V
W
L
T
K
K
G
N
P
L
F
R
K
I
Q
E
S
T
D
E
V
N
R
V
V
-------
R
E
N
L
L
G
V
R
V
V
R
A
F
R
R
E
E
Y
E
N
E
N
F
R
K
A
N
E
S
L
R
R
S
I
I
-
S
A
F
S
L
I
V
F
-
A
L
P
L
F
I
F
I
V
N
M
G
M
I
A
V
L
W
F
G
G
V
L
V
R
-
N
N
Q
M
E
I
G
S
I
M
A
Y
T
N
Y
L
M
Q
I
M
F
S
L
M
M
I
G
N
I
L
N
F
I
V
R
A
S
A
S
A
K
R
V
L
E
V
L
N
E
K
P
A
I
E
E
A
-----
D
-
N
A
-
L
A
L
P
N
V
E
G
S
---
V
S
F
E
N
V
E
F
R
Y
F
E
N
------
T
D
P
V
L
S
G
V
N
F
S
V
K
P
G
S
L
V
A
V
L
G
E
T
G
S
G
K
S
T
L
M
N
L
I
P
R
L
I
D
P
E
R
G
R
V
E
V
D
E
L
D
V
R
T
V
K
L
K
D
L
R
G
H
I
S
A
V
P
Q
E
T
V
L
F
S
G
T
I
K
E
N
L
K
W
G
-
R
E
D
---
A
T
D
D
E
I
V
E
A
A
K
I
A
Q
I
H
D
F
I
I
S
L
P
E
G
Y
-
D
S
R
V
E
R
G
G
R
N
F
S
G
G
Q
K
Q
R
L
S
I
A
R
A
L
V
K
K
P
K
-
V
L
I
L
D
D
S
T
C
S
V
D
P
I
T
E
K
R
I
L
D
G
L
K
R
Y
T
K
G
S
T
T
F
I
I
T
Q
K
I
P
T
A
L
L
A
D
K
I
L
V
L
H
E
G
K
V
A
G
F
G
T
H
K
E
L
L
E
H
S
-
K
P
Y
R
E
I
Y
E
S
Q
F
----
2
PsiBlast_PDB
85.65
33%
-37
- C1 -
-
4Q4A
1
?
A:
[12-579]
----
K
T
L
A
R
Y
L
K
P
Y
---
W
I
F
A
V
L
A
P
L
F
M
V
-
V
E
V
I
C
D
L
S
Q
P
T
L
L
A
R
I
V
D
E
G
I
A
R
G
D
-------
F
--
S
-
L
----
V
L
K
---
T
G
I
L
-
M
L
I
V
A
L
I
G
A
V
G
G
I
G
C
T
V
F
A
S
Y
A
S
Q
N
F
G
A
D
L
R
R
D
L
F
R
K
V
L
S
F
S
I
S
N
V
N
R
F
H
T
S
S
L
I
T
R
L
T
N
D
V
T
Q
L
Q
N
L
V
-
M
M
L
L
R
I
V
V
R
A
P
L
L
F
V
G
G
I
V
M
A
V
-
S
I
N
V
K
L
S
S
V
L
I
F
L
I
P
P
I
V
L
L
F
V
W
L
T
K
K
G
N
P
L
F
R
K
I
Q
E
S
T
D
E
V
N
R
V
V
-------
R
E
N
L
L
G
V
R
V
V
R
A
F
R
R
E
E
Y
E
N
E
N
F
R
K
A
N
E
S
L
R
R
S
I
I
-
S
A
F
S
L
I
V
F
-
A
L
P
L
F
I
F
I
V
N
M
G
M
I
A
V
L
W
F
G
G
V
L
V
R
-
N
N
Q
M
E
I
G
S
I
M
A
Y
T
N
Y
L
M
Q
I
M
F
S
L
M
M
I
G
N
I
L
N
F
I
V
R
A
S
A
S
A
K
R
V
L
E
V
L
N
E
K
P
A
I
E
E
A
-----
D
-
N
A
-
L
A
L
P
N
V
E
G
S
---
V
S
F
E
N
V
E
F
R
Y
F
E
N
------
T
D
P
V
L
S
G
V
N
F
S
V
K
P
G
S
L
V
A
V
L
G
E
T
G
S
G
K
S
T
L
M
N
L
I
P
R
L
I
D
P
E
R
G
R
V
E
V
D
E
L
D
V
R
T
V
K
L
K
D
L
R
G
H
I
S
A
V
P
Q
E
T
V
L
F
S
G
T
I
K
E
N
L
K
W
G
-
R
E
D
---
A
T
D
D
E
I
V
E
A
A
K
I
A
Q
I
H
D
F
I
I
S
L
P
E
G
Y
-
D
S
R
V
E
R
G
G
R
N
F
S
G
G
Q
K
Q
R
L
S
I
A
R
A
L
V
K
K
P
K
-
V
L
I
L
D
D
C
T
S
S
V
D
P
I
T
E
K
R
I
L
D
G
L
K
R
Y
T
K
G
C
T
T
F
I
I
T
Q
K
I
P
T
A
L
L
A
D
K
I
L
V
L
H
E
G
K
V
A
G
F
G
T
H
K
E
L
L
E
H
C
-
K
P
Y
R
E
I
Y
E
S
Q
F
----
88
HHSearch
77.03
24%
-67
- C1 -
-
3QF4
1
Y288_THEMA
B:
[26-588]
----
R
R
L
L
G
Y
L
R
P
H
---
T
F
T
L
I
M
V
F
V
F
V
T
-
V
S
S
I
L
G
V
L
S
P
Y
L
I
G
K
T
I
D
V
V
F
V
P
R
R
-------
F
--
D
L
L
----
P
R
Y
---
M
L
-
I
-
L
G
T
I
Y
A
L
T
S
L
L
F
W
L
Q
G
K
I
M
L
T
L
S
Q
D
V
V
F
R
L
R
K
E
L
F
E
K
L
Q
R
V
P
V
G
F
F
D
R
T
P
H
G
D
I
I
S
R
V
I
N
D
V
D
N
I
N
N
V
L
-
G
N
S
I
I
Q
F
F
S
G
I
V
T
L
A
G
A
V
I
M
M
F
-
R
V
N
V
I
L
S
L
V
T
L
S
I
V
P
L
T
V
L
I
T
Q
I
V
S
S
Q
T
R
K
Y
F
Y
E
N
Q
R
V
L
G
Q
L
N
G
I
I
-------
E
E
D
I
S
G
L
T
V
I
K
L
F
T
R
E
E
K
E
M
E
K
F
D
R
V
N
E
S
L
R
K
V
G
T
-
K
A
Q
I
F
S
G
V
-
L
P
P
L
M
N
M
V
N
N
L
G
F
A
L
I
S
G
F
G
G
W
L
-
A
L
K
D
I
I
T
V
G
T
I
A
T
F
I
G
Y
S
R
Q
F
T
R
P
L
N
E
L
S
N
Q
F
N
M
I
Q
M
A
L
A
S
A
E
R
I
F
E
I
L
D
L
E
E
E
K
D
D
P
-----
D
-
A
--
V
E
L
R
E
V
R
G
E
---
I
E
F
K
N
V
W
F
S
Y
D
K
K
-------
K
P
V
L
K
D
I
T
F
H
I
K
P
G
Q
K
V
A
L
V
G
P
T
G
S
G
K
T
T
I
V
N
L
L
M
R
F
Y
D
V
D
R
G
Q
I
L
V
D
G
I
D
I
R
K
I
K
R
S
S
L
R
S
S
I
G
I
V
L
Q
D
T
I
L
F
S
T
T
V
K
E
N
L
K
Y
G
N
-
P
G
---
A
T
D
E
E
I
K
E
A
A
K
L
T
H
S
D
H
F
I
-
K
H
L
P
E
G
Y
E
T
V
L
T
D
N
G
E
D
L
S
Q
G
Q
R
Q
L
L
A
I
T
R
A
F
L
A
N
P
K
-
I
L
I
L
D
E
A
T
S
N
V
D
T
K
T
E
K
S
I
Q
A
A
M
W
K
L
M
E
G
K
T
S
I
I
I
A
H
R
L
N
T
I
K
N
A
D
L
I
I
V
L
R
D
G
E
I
V
E
M
G
K
H
D
E
L
I
Q
K
R
-
G
F
Y
Y
E
L
F
T
-------
7
PsiBlast_PDB
75.71
26%
-
- C1 -
-
3B5Z
2
MSBA_SALTY
A:
[14-581]
----
R
R
L
W
P
T
I
A
P
F
---
K
A
G
L
I
V
A
G
I
A
L
I
-
L
N
A
A
S
D
T
F
M
L
S
L
L
K
P
L
L
D
D
G
F
G
K
T
D
-------
R
--
S
V
L
L
---
W
M
P
L
V
V
I
G
-
L
-
M
I
L
R
G
I
T
S
Y
I
S
S
Y
C
I
S
W
V
S
G
K
V
V
M
----
T
M
R
R
R
L
F
G
H
M
M
G
M
P
V
A
F
F
D
K
Q
S
T
G
T
L
L
S
R
I
T
Y
D
S
E
Q
V
A
S
S
S
-
S
G
A
L
I
T
V
V
R
E
G
A
S
I
I
G
L
F
I
M
M
F
-
Y
Y
S
W
Q
L
S
I
I
L
V
V
L
A
P
I
V
S
I
A
I
R
V
V
S
K
R
F
R
S
I
S
K
N
M
Q
N
T
M
G
Q
V
T
T
S
A
-------
E
Q
M
L
K
G
H
K
E
V
L
I
F
G
G
Q
E
V
E
T
K
R
F
D
K
V
S
N
-
K
M
R
L
Q
G
M
K
M
V
S
A
S
S
I
-
S
D
P
I
I
Q
L
I
A
S
L
A
L
A
F
V
L
Y
A
A
S
F
P
S
V
-
M
D
S
L
T
A
G
T
I
T
V
V
F
S
S
M
I
A
L
M
R
P
L
K
S
L
T
N
V
N
A
Q
F
Q
R
G
M
A
A
C
Q
T
L
F
A
I
L
D
S
E
Q
E
K
D
E
G
-----
K
-
R
V
-
I
D
R
A
T
G
D
-----
L
E
F
R
N
V
T
F
T
Y
P
G
R
------
E
V
P
A
L
R
N
I
N
L
K
I
P
A
G
K
T
V
A
L
V
G
R
S
G
S
G
K
S
T
I
A
S
L
I
T
R
F
Y
D
I
D
E
G
H
I
L
M
D
G
H
D
L
R
E
Y
T
L
A
S
L
R
N
Q
V
A
L
V
S
Q
N
V
H
L
F
N
D
T
V
A
N
N
I
A
Y
A
R
T
E
E
---
Y
S
R
E
Q
I
E
E
A
A
R
M
A
Y
A
M
D
F
I
-
N
K
M
D
N
G
L
D
T
I
I
G
E
N
G
V
L
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
L
R
D
S
P
-
I
L
I
L
D
E
A
T
S
A
L
D
T
E
S
E
R
A
I
Q
A
A
L
D
E
L
Q
K
N
R
T
S
L
V
I
A
H
R
L
S
T
I
E
Q
A
D
E
I
V
V
V
E
D
G
I
I
V
E
R
G
T
H
S
E
L
L
A
Q
H
-
G
V
Y
A
Q
L
H
K
M
Q
F
G
---
6
PsiBlast_PDB
75.70
26%
-
- C1 -
-
3B5Y
2
MSBA_SALTY
A:
[14-581]
----
R
R
L
W
P
T
I
A
P
F
---
K
A
G
L
I
V
A
G
I
A
L
I
-
L
N
A
A
S
D
T
F
M
L
S
L
L
K
P
L
L
D
D
G
F
G
K
T
D
-------
R
--
S
V
L
L---
W
M
P
L
V
V
I
G
-
L
-
M
I
L
R
G
I
T
S
Y
I
S
S
Y
C
I
S
W
V
S
G
K
V
V
M
----
T
M
R
R
R
L
F
G
H
M
M
G
M
P
V
A
F
F
D
K
Q
S
T
G
T
L
L
S
R
I
T
Y
D
S
E
Q
V
A
S
S
S
-
S
G
A
L
I
T
V
V
R
E
G
A
S
I
I
G
L
F
I
M
M
F
-
Y
Y
S
W
Q
L
S
I
I
L
V
V
L
A
P
I
V
S
I
A
I
R
V
V
S
K
R
F
R
S
I
S
K
N
M
Q
N
T
M
G
Q
V
T
T
S
A
-------
E
Q
M
L
K
G
H
K
E
V
L
I
F
G
G
Q
E
V
E
T
K
R
F
D
K
V
S
N
-
K
M
R
L
Q
G
M
K
M
V
S
A
S
S
I
-
S
D
P
I
I
Q
L
I
A
S
L
A
L
A
F
V
L
Y
A
A
S
F
P
S
V
-
M
D
S
L
T
A
G
T
I
T
V
V
F
S
S
M
I
A
L
M
R
P
L
K
S
L
T
N
V
N
A
Q
F
Q
R
G
M
A
A
C
Q
T
L
F
A
I
L
D
S
E
Q
E
K
D
E
G
-----
K
-
R
V
-
I
D
R
A
T
G
D
-----
L
E
F
R
N
V
T
F
T
Y
P
G
R
------
E
V
P
A
L
R
N
I
N
L
K
I
P
A
G
K
T
V
A
L
V
G
R
S
G
S
G
K
S
T
I
A
S
L
I
T
R
F
Y
D
I
D
E
G
H
I
L
M
D
G
H
D
L
R
E
Y
T
L
A
S
L
R
N
Q
V
A
L
V
S
Q
N
V
H
L
F
N
D
T
V
A
N
N
I
A
Y
A
R
T
E
E
---
Y
S
R
E
Q
I
E
E
A
A
R
M
A
Y
A
M
D
F
I
-
N
K
M
D
N
G
L
D
T
I
I
G
E
N
G
V
L
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
L
R
D
S
P
-
I
L
I
L
D
E
A
T
S
A
L
D
T
E
S
E
R
A
I
Q
A
A
L
D
E
L
Q
K
N
R
T
S
L
V
I
A
H
R
L
S
T
I
E
Q
A
D
E
I
V
V
V
E
D
G
I
I
V
E
R
G
T
H
S
E
L
L
A
Q
H
-
G
V
Y
A
Q
L
H
K
M
Q
F
G
---
90
HHSearch
74.15
24%
-38
- C1 -
-
5MKK
-
?
A:
[16-586]
-----
R
I
L
R
Y
V
W
P
Y
---
R
L
Q
V
V
L
A
L
L
F
L
L
-
V
V
T
L
A
A
A
A
T
P
L
F
F
K
W
A
I
D
L
A
L
V
P
T
E
PR
P
L
A
E
R
F
--
H
L
L
----
L
W
I
---
S
L
-
G
-
F
L
A
V
R
A
V
H
F
A
A
T
Y
G
E
T
Y
L
I
Q
W
V
G
Q
R
V
L
F
D
L
R
S
D
L
F
A
K
L
M
R
L
H
P
G
F
Y
D
R
N
P
V
G
R
L
M
T
R
V
T
S
D
V
D
A
I
N
Q
F
I
-
T
G
G
L
V
G
V
I
A
D
L
F
T
L
V
G
L
L
G
F
M
L
-
F
L
S
P
K
L
T
L
V
V
L
L
V
A
P
V
L
L
A
V
T
T
W
V
R
L
G
M
R
S
A
Y
R
E
M
R
L
R
L
A
R
V
N
A
A
L
-------
Q
E
N
L
S
G
V
E
T
I
Q
L
F
V
K
E
R
E
R
E
E
K
F
D
R
L
N
R
D
L
F
R
A
W
V
-
E
I
I
R
W
F
A
L
-
F
F
P
V
V
G
F
L
G
D
F
A
V
A
S
L
V
Y
Y
G
G
G
E
-
V
V
R
G
A
V
S
L
G
L
L
V
A
F
V
D
Y
T
R
Q
L
F
Q
P
L
Q
D
L
S
D
K
F
N
L
F
Q
G
A
M
A
S
A
E
R
I
F
G
V
L
D
T
E
E
E
L
K
D
P
-----
E
-
D
P
-
T
P
I
R
G
F
R
G
E
---
V
E
F
R
D
V
W
L
A
Y
T
P
K
GVEPTE
K
D
W
V
L
K
G
V
S
F
R
V
R
P
G
E
K
V
A
L
V
G
A
T
G
A
G
K
T
S
V
V
S
L
I
A
R
F
Y
D
P
Q
R
G
C
V
F
L
D
G
V
D
V
R
R
Y
R
Q
E
E
L
R
R
H
V
G
I
V
L
Q
E
P
F
L
F
S
G
T
V
L
D
N
L
R
L
F
D
-
P
S
---
V
P
P
E
R
V
E
E
V
A
R
F
L
G
A
H
E
F
I
-
L
R
L
P
K
G
Y
Q
T
V
L
G
E
R
G
A
G
L
S
T
G
E
K
Q
L
L
A
L
V
R
A
L
L
A
S
P
D
I
L
L
I
L
D
E
A
T
A
S
V
D
S
E
T
E
K
R
L
Q
E
A
L
Y
K
A
M
E
G
R
T
S
L
I
I
A
H
R
L
S
T
I
R
H
V
D
R
I
L
V
F
R
K
G
R
L
V
E
E
G
S
H
E
E
L
L
A
K
G
-
G
--------------
82
HHSearch
73.23
24%
-62
- C1 -
-
5MKK
-
?
B:
[10-569]
----
R
R
L
W
P
Y
V
G
R
Y
---
R
W
R
Y
L
W
A
V
L
A
G
L
-
V
S
I
F
F
F
V
L
T
P
Y
F
L
R
L
A
V
D
A
V
Q
A
G
R
G
------------
F
----
G
V
Y
---
A
L
-
A
-
I
V
A
S
A
A
L
S
G
L
L
S
Y
A
M
R
R
L
A
V
V
A
S
R
Q
V
E
Y
D
L
R
R
D
L
L
H
H
L
L
T
L
D
R
D
F
Y
H
K
H
R
V
G
D
L
M
N
R
L
N
T
D
L
S
A
V
R
E
M
V
-
G
P
G
I
L
M
G
S
R
L
S
F
L
V
L
L
A
F
L
S
M
Y
-
A
V
N
A
R
L
A
F
Y
L
T
L
I
L
P
G
I
F
L
A
M
R
F
L
L
R
L
I
D
R
R
Y
R
E
A
Q
E
V
F
D
R
I
S
T
L
A
-------
Q
E
A
F
S
G
I
R
V
V
K
G
Y
A
L
E
R
R
M
V
A
W
F
Q
D
L
N
R
L
Y
V
E
K
S
L
-
A
L
A
R
V
E
G
P
-
L
H
A
L
L
G
F
L
M
G
F
A
F
L
T
V
L
W
A
G
G
A
M
-
V
V
R
G
E
L
S
V
G
E
L
V
Q
F
N
A
Y
L
A
Q
L
T
W
P
I
L
G
L
G
W
V
M
A
L
Y
Q
R
G
L
T
S
L
R
R
L
F
E
L
L
D
E
K
P
A
I
R
D
E
-----
D
P
L
P
-
L
A
L
E
D
L
S
G
E
---
V
R
F
E
G
V
G
L
K
R
D
G
--------
R
W
L
L
R
G
L
T
L
T
I
P
E
G
M
T
L
G
I
T
G
R
T
G
S
G
K
S
L
L
A
A
L
V
P
R
L
L
D
P
S
E
G
R
V
Y
V
G
G
H
E
A
R
R
I
P
L
A
V
L
R
K
A
V
G
V
A
P
Q
E
P
F
L
F
S
E
T
I
L
E
N
I
A
F
G
L
-
D
E
---
V
D
R
E
R
V
E
W
A
A
R
L
A
G
I
H
E
E
I
-
L
A
F
P
K
G
Y
E
T
V
L
G
E
R
G
I
T
L
S
G
G
Q
R
Q
R
V
A
L
A
R
A
L
A
K
R
P
K
-
I
L
I
L
D
D
A
L
S
A
V
D
A
E
T
E
A
R
I
L
Q
G
L
K
T
V
L
G
K
Q
T
T
L
L
I
S
H
R
T
A
A
L
R
H
A
D
W
I
I
V
L
D
G
G
R
I
V
E
E
G
T
H
E
S
L
L
Q
A
G
-
G
L
Y
A
E
M
D
--------
65
Fugue
73.23
24%
-34
- C1 -
-
3B60
2
MSBA_SALTY
A:
[10-581]
W
Q
T
F
R
R
L
W
P
T
I
A
P
F
---
K
A
G
L
I
V
A
G
I
A
L
I
-
L
N
A
A
S
D
T
F
M
L
S
L
L
K
P
L
L
D
D
G
F
G
K
T
D
-------
R
--
S
V
L
----
L
W
M
---
P
L
-
V
-
V
I
G
L
M
I
L
R
G
I
T
S
Y
I
S
S
Y
C
I
S
W
V
S
G
K
V
V
M
T
M
R
R
R
L
F
G
H
M
M
G
M
P
V
A
F
F
D
K
Q
S
T
G
T
L
L
S
R
I
T
Y
D
S
E
Q
V
A
S
S
S
-
S
G
A
L
I
T
V
V
R
E
G
A
S
I
I
G
L
F
I
M
M
F
-
Y
Y
S
W
Q
L
S
I
I
L
V
V
L
A
P
I
V
S
I
A
I
R
V
V
S
K
R
F
R
S
I
S
K
N
M
Q
N
T
M
G
Q
V
T
T
S
A
-------
E
Q
M
L
K
G
H
K
E
V
L
I
F
G
G
Q
E
V
E
T
K
R
F
D
K
V
S
N
K
M
R
L
Q
G
M
-
K
M
V
S
A
S
S
I
-
S
D
P
I
I
Q
L
I
A
S
L
A
L
A
F
V
L
Y
A
A
S
F
P
S
V
-
M
D
S
L
T
A
G
T
I
T
V
V
F
S
S
M
I
A
L
M
R
P
L
K
S
L
T
N
V
N
A
Q
F
Q
R
G
M
A
A
C
Q
T
L
F
A
I
L
D
S
E
Q
E
K
D
E
G
-----
K
-
R
V
-
I
D
R
A
T
G
D
-----
L
E
F
R
N
V
T
F
T
Y
P
G
R
------
E
V
P
A
L
R
N
I
N
L
K
I
P
A
G
K
T
V
A
L
V
G
R
S
G
S
G
K
S
T
I
A
S
L
I
T
R
F
Y
D
I
D
E
G
H
I
L
M
D
G
H
D
L
R
E
Y
T
L
A
S
L
R
N
Q
V
A
L
V
S
Q
N
V
H
L
F
N
D
T
V
A
N
N
I
A
Y
A
R
T
E
E
---
Y
S
R
E
Q
I
E
E
A
A
R
M
A
Y
A
M
D
F
I
-
N
K
M
D
N
G
L
D
T
I
I
G
E
N
G
V
L
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
L
R
D
S
P
-
I
L
I
L
D
E
A
T
S
A
L
D
T
E
S
E
R
A
I
Q
A
A
L
D
E
L
Q
K
N
R
T
S
L
V
I
A
H
R
L
S
T
I
E
Q
A
D
E
I
V
V
V
E
D
G
I
I
V
E
R
G
T
H
S
E
L
L
A
Q
H
-
G
V
Y
A
Q
L
H
K
M
Q
F
G
---
78
HHSearch
73.09
25%
-10
- C1 -
-
4AYX
6
ABCBA_HUMAN
A:
[8-574]
----
R
K
L
L
G
L
A
Y
P
E
---
R
R
R
L
A
A
A
V
G
F
L
T
-
M
S
S
V
I
S
M
S
A
P
F
F
L
G
K
I
I
D
V
I
Y
T
N
P
T
VDY----
S
--
D
N
L
----
T
R
L
---
C
L
-
G
-
L
S
A
V
F
L
C
G
A
A
A
N
A
I
R
V
Y
L
M
Q
T
S
G
Q
R
I
V
N
R
L
R
T
S
L
F
S
S
I
L
R
Q
E
V
A
F
F
D
K
T
R
T
G
E
L
I
N
R
L
S
S
D
T
A
L
L
G
R
S
V
-
T
E
N
L
S
D
G
L
R
A
G
A
Q
A
S
V
G
I
S
M
M
F
-
F
V
S
P
N
L
A
T
F
V
L
S
V
V
P
P
V
S
I
I
A
V
I
Y
G
R
Y
L
R
K
L
T
K
V
T
Q
D
S
L
A
Q
A
T
Q
L
A
-------
E
E
R
I
G
N
V
R
T
V
R
A
F
G
K
E
M
T
E
I
E
K
Y
A
S
K
V
D
H
V
M
Q
L
A
R
-
K
E
A
F
A
R
A
G
-
F
F
G
A
T
G
L
S
G
N
L
I
V
L
S
V
L
Y
K
G
G
L
L
-
M
G
S
A
H
M
T
V
G
E
L
S
S
F
L
M
Y
A
F
W
V
G
I
S
I
G
G
L
S
S
F
Y
S
E
L
M
K
G
L
G
A
G
G
R
L
W
E
L
L
E
R
E
P
K
L
P
F
N
-----
E
-
G
V
I
L
N
E
K
S
F
Q
G
A
---
L
E
F
K
N
V
H
F
A
Y
P
A
R
P-----
E
V
P
I
F
Q
D
F
S
L
S
I
P
S
G
S
V
T
A
L
V
G
P
S
G
S
G
K
S
T
V
L
S
L
L
L
R
L
Y
D
P
A
S
G
T
I
S
L
D
G
H
D
I
R
Q
L
N
P
V
W
L
R
S
K
I
G
T
V
S
Q
E
P
I
L
F
S
C
S
I
A
E
N
I
A
Y
G
A
-
D
D
PSS
V
T
A
E
E
I
Q
R
V
A
E
V
A
N
A
V
A
F
I
-
R
N
F
P
Q
G
F
N
T
V
V
G
E
K
G
V
L
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
L
K
N
P
K
-
I
L
L
L
D
E
A
T
S
A
L
D
A
E
N
E
Y
L
V
Q
E
A
L
D
R
L
M
D
G
R
T
V
L
V
I
A
H
R
L
S
T
I
K
N
A
N
M
V
A
V
L
D
Q
G
K
I
T
E
Y
G
K
H
E
E
L
L
S
K
P
N
G
--------------
77
HHSearch
72.61
25%
-14
- C1 -
-
4AYT
7
ABCBA_HUMAN
A:
[8-567]
----
R
K
L
L
G
L
A
Y
P
E
---
R
R
R
L
A
A
A
V
G
F
L
T
-
M
S
S
V
I
S
M
S
A
P
F
F
L
G
K
I
I
D
V
I
Y
T
N
P
T
VDY----
S
--
D
N
L
----
T
R
L
---
C
L
-
G
-
L
S
A
V
F
L
C
G
A
A
A
N
A
I
R
V
Y
L
M
Q
T
S
G
Q
R
I
V
N
R
L
R
T
S
L
F
S
S
I
L
R
Q
E
V
A
F
F
D
K
T
R
T
G
E
L
I
N
R
L
S
S
D
T
A
L
L
G
R
S
V
-
T
E
N
L
S
D
G
L
R
A
G
A
Q
A
S
V
G
I
S
M
M
F
-
F
V
S
P
N
L
A
T
F
V
L
S
V
V
P
P
V
S
I
I
A
V
I
Y
G
R
Y
L
R
K
L
T
K
V
T
Q
D
S
L
A
Q
A
T
Q
L
A
-------
E
E
R
I
G
N
V
R
T
V
R
A
F
G
K
E
M
T
E
I
E
K
Y
A
S
K
V
D
H
V
M
Q
L
A
R
-
K
E
A
F
A
R
A
G
-
F
F
G
A
T
G
L
S
G
N
L
I
V
L
S
V
L
Y
K
G
G
L
L
-
M
G
S
A
H
M
T
V
G
E
L
S
S
F
L
M
Y
A
F
W
V
G
I
S
I
G
G
L
S
S
F
Y
S
E
L
M
K
G
L
G
A
G
G
R
L
W
E
L
L
E
R
E
P
K
L
P
F
N
-----
E
-
G
V
I
L
N
E
K
S
F
Q
G
A
---
L
E
F
K
N
V
H
F
A
Y
P
A
R
P-----
E
V
P
I
F
Q
D
F
S
L
S
I
P
S
G
S
V
T
A
L
V
G
P
S
G
S
G
K
S
T
V
L
S
L
L
L
R
L
Y
D
P
A
S
G
T
I
S
L
D
G
H
D
I
R
Q
L
N
P
V
W
L
R
S
K
I
G
T
V
S
Q
E
P
I
L
F
S
C
S
I
A
E
N
I
A
Y
G
A
-
D
D
PSS
V
T
A
E
E
I
Q
R
V
A
E
V
A
N
A
V
A
F
I
-
R
N
F
P
Q
G
F
N
T
V
V
G
E
K
G
V
L
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
L
K
N
P
K
-
I
L
L
L
D
E
A
T
S
A
L
D
A
E
N
E
Y
L
V
Q
E
A
L
D
R
L
M
D
G
R
T
V
L
V
I
A
H
R
L
S
T
I
K
N
A
N
M
V
A
V
L
D
Q
G
K
I
T
E
Y
G
K
H
E
E
---------------------
13
PsiBlast_PDB
72.45
26%
-16
- C1 -
-
2ONJ
2
Y1866_STAAM
A:
[2-577]
---
I
K
R
Y
L
Q
F
V
K
P
Y
K
Y
R
I
F
A
T
I
I
V
G
I
I
K
F
G
I
P
M
L
I
P
L
L
I
K
Y
A
I
D
G
V
I
N
N
H
A
L
T
T
D
-------
E
K
V
H
H
L
----
T
I
A
---
I
G
-
I
A
L
F
I
F
V
I
V
R
P
P
I
E
F
I
R
Q
Y
L
A
Q
W
T
S
N
K
I
L
Y
D
I
R
K
K
L
Y
N
H
L
Q
A
L
S
A
R
F
Y
A
N
N
Q
V
G
Q
V
I
S
R
V
I
N
D
V
E
Q
T
K
D
F
I
L
T
G
L
M
N
I
W
L
D
C
I
T
I
I
I
A
L
S
I
M
F
F
L
D
V
K
L
T
L
A
A
L
F
I
F
P
F
Y
I
L
T
V
Y
V
---------
F
F
G
R
L
R
K
L
T
R
E
R
S
Q
A
L
A
E
V
Q
G
F
L
H
E
R
V
Q
G
I
S
V
V
K
S
F
A
I
E
D
N
E
A
K
N
F
D
K
K
N
T
N
F
L
T
R
A
L
-
K
H
T
R
W
N
A
Y
S
F
A
A
I
N
T
V
T
D
I
G
P
I
I
V
I
G
V
G
A
Y
L
A
I
S
-
G
S
I
-
T
V
G
T
L
A
A
F
V
G
Y
L
E
L
L
F
G
P
L
R
R
L
V
A
S
F
T
T
L
T
Q
S
F
A
S
M
D
R
V
F
Q
L
-
I
D
E
D
Y
D
I
K
N
GVGAQ
P
-
I
E
-
I
K
Q
G
R
I
D
-------
I
D
H
V
S
F
Q
Y
N
D
N
------
E
A
P
I
L
K
D
I
N
L
S
I
E
K
G
E
T
V
A
F
V
G
M
S
G
G
G
K
S
T
L
I
N
L
I
P
R
F
Y
D
V
T
S
G
Q
I
L
I
D
G
H
N
I
K
D
F
L
T
G
S
L
R
N
Q
I
G
L
V
Q
Q
D
N
I
L
F
S
D
T
V
K
E
N
I
L
L
G
-
R
P
T
---
A
T
D
E
E
V
V
E
A
A
K
M
A
N
A
H
D
F
I
-
M
N
L
P
Q
G
Y
D
T
E
V
G
E
R
G
V
K
L
S
G
G
Q
K
Q
R
L
S
I
A
R
I
F
L
N
N
P
P
-
I
L
I
L
D
E
A
T
S
A
L
D
L
E
S
E
S
I
I
Q
E
A
L
D
V
L
S
K
D
R
T
T
L
I
V
A
H
R
L
S
T
I
T
H
A
D
K
I
V
V
I
E
N
G
H
I
V
E
T
G
T
H
R
E
L
I
A
K
Q
-
G
A
Y
E
H
L
Y
S
I
Q
N
----
12
PsiBlast_PDB
72.33
26%
-18
- C1 -
-
2HYD
2
Y1866_STAAM
A:
[2-577]
---
I
K
R
Y
L
Q
F
V
K
P
Y
K
Y
R
I
F
A
T
I
I
V
G
I
I
K
F
G
I
P
M
L
I
P
L
L
I
K
Y
A
I
D
G
V
I
N
N
H
A
L
T
T
D
-------
E
K
V
H
H
L
----
T
I
A
---
I
G
-
I
A
L
F
I
F
V
I
V
R
P
P
I
E
F
I
R
Q
Y
L
A
Q
W
T
S
N
K
I
L
Y
D
I
R
K
K
L
Y
N
H
L
Q
A
L
S
A
R
F
Y
A
N
N
Q
V
G
Q
V
I
S
R
V
I
N
D
V
E
Q
T
K
D
F
I
L
T
G
L
M
N
I
W
L
D
C
I
T
I
I
I
A
L
S
I
M
F
F
L
D
V
K
L
T
L
A
A
L
F
I
F
P
F
Y
I
L
T
V
Y
V
---------
F
F
G
R
L
R
K
L
T
R
E
R
S
Q
A
L
A
E
V
Q
G
F
L
H
E
R
V
Q
G
I
S
V
V
K
S
F
A
I
E
D
N
E
A
K
N
F
D
K
K
N
T
N
F
L
T
R
A
L
-
K
H
T
R
W
N
A
Y
S
F
A
A
I
N
T
V
T
D
I
G
P
I
I
V
I
G
V
G
A
Y
L
A
I
S
-
G
S
I
-
T
V
G
T
L
A
A
F
V
G
Y
L
E
L
L
F
G
P
L
R
R
L
V
A
S
F
T
T
L
T
Q
S
F
A
S
M
D
R
V
F
Q
L
-
I
D
E
D
Y
D
I
K
N
GVGAQ
P
-
I
E
-
I
K
Q
G
R
I
D
-------
I
D
H
V
S
F
Q
Y
N
D
N
------
E
A
P
I
L
K
D
I
N
L
S
I
E
K
G
E
T
V
A
F
V
G
M
S
G
G
G
K
S
T
L
I
N
L
I
P
R
F
Y
D
V
T
S
G
Q
I
L
I
D
G
H
N
I
K
D
F
L
T
G
S
L
R
N
Q
I
G
L
V
Q
Q
D
N
I
L
F
S
D
T
V
K
E
N
I
L
L
G
-
R
P
T
---
A
T
D
E
E
V
V
E
A
A
K
M
A
N
A
H
D
F
I
-
M
N
L
P
Q
G
Y
D
T
E
V
G
E
R
G
V
K
L
S
G
G
Q
K
Q
R
L
S
I
A
R
I
F
L
N
N
P
P
-
I
L
I
L
D
E
A
T
S
A
L
D
L
E
S
E
S
I
I
Q
E
A
L
D
V
L
S
K
D
R
T
T
L
I
V
A
H
R
L
S
T
I
T
H
A
D
K
I
V
V
I
E
N
G
H
I
V
E
T
G
T
H
R
E
L
I
A
K
Q
-
G
A
Y
E
H
L
Y
S
I
Q
N
----
5
PsiBlast_PDB
72.30
25%
-
- C1 -
-
3B5W
-
MSBA_ECOLI
A:
[14-581]
----
R
R
L
W
P
T
I
A
P
F
---
K
A
G
L
I
V
A
G
V
A
L
I
-
L
N
A
A
S
D
T
F
M
L
S
L
L
K
P
L
L
D
D
G
F
G
K
T
D
-------
R
--
S
V
L
V
---
W
M
P
L
V
V
I
G
-
L
-
M
I
L
R
G
I
T
S
Y
V
S
S
Y
C
I
S
W
V
S
G
K
V
V
M
----
T
M
R
R
R
L
F
G
H
M
M
G
M
P
V
S
F
F
D
K
Q
S
T
G
T
L
L
S
R
I
T
Y
D
S
E
Q
V
A
S
S
S
-
S
G
A
L
I
T
V
V
R
E
G
A
S
I
I
G
L
F
I
M
M
F
-
Y
Y
S
W
Q
L
S
I
I
L
I
V
L
A
P
I
V
S
I
A
I
R
V
V
S
K
R
F
R
N
I
S
K
N
M
Q
N
T
M
G
Q
V
T
T
S
A
-------
E
Q
M
L
K
G
H
K
E
V
L
I
F
G
G
Q
E
V
E
T
K
R
F
D
K
V
S
N
-
R
M
R
L
Q
G
M
K
M
V
S
A
S
S
I
-
S
D
P
I
I
Q
L
I
A
S
L
A
L
A
F
V
L
Y
A
A
S
F
P
S
V
-
M
D
S
L
T
A
G
T
I
T
V
V
F
S
S
M
I
A
L
M
R
P
L
K
S
L
T
N
V
N
A
Q
F
Q
R
G
M
A
A
C
Q
T
L
F
T
I
L
D
S
E
Q
E
K
D
E
G
-----
K
-
R
V
-
I
E
R
A
T
G
D
-----
V
E
F
R
N
V
T
F
T
Y
P
G
R
------
D
V
P
A
L
R
N
I
N
L
K
I
P
A
G
K
T
V
A
L
V
G
R
S
G
S
G
K
S
T
I
A
S
L
I
T
R
F
Y
D
I
D
E
G
E
I
L
M
D
G
H
D
L
R
E
Y
T
L
A
S
L
R
N
Q
V
A
L
V
S
Q
N
V
H
L
F
N
D
T
V
A
N
N
I
A
Y
A
R
T
E
Q
---
Y
S
R
E
Q
I
E
E
A
A
R
M
A
Y
A
M
D
F
I
-
N
K
M
D
N
G
L
D
T
V
I
G
E
N
G
V
L
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
L
R
D
S
P
-
I
L
I
L
D
E
A
T
S
A
L
D
T
E
S
E
R
A
I
Q
A
A
L
D
E
L
Q
K
N
R
T
S
L
V
I
A
H
R
L
S
T
I
E
K
A
D
E
I
V
V
V
E
D
G
V
I
V
E
R
G
T
H
N
D
L
L
E
H
R
-
G
V
Y
A
Q
L
H
K
M
Q
F
G
---
75
HHSearch
72.13
24%
-34
- C1 -
-
3B60
2
MSBA_SALTY
D:
[15-574]
-----
R
L
W
P
T
I
A
P
F
---
K
A
G
L
I
V
A
G
I
A
L
I
-
L
N
A
A
S
D
T
F
M
L
S
L
L
K
P
L
L
D
D
G
F
G
K
T
D
-------
R
--
S
V
L
----
L
W
M
---
P
L
-
V
-
V
I
G
L
M
I
L
R
G
I
T
S
Y
I
S
S
Y
C
I
S
W
V
S
G
K
V
V
M
T
M
R
R
R
L
F
G
H
M
M
G
M
P
V
A
F
F
D
K
Q
S
T
G
T
L
L
S
R
I
T
Y
D
S
E
Q
V
A
S
S
S
-
S
G
A
L
I
T
V
V
R
E
G
A
S
I
I
G
L
F
I
M
M
F
-
Y
Y
S
W
Q
L
S
I
I
L
V
V
L
A
P
I
V
S
I
A
I
R
V
V
S
K
R
F
R
S
I
S
K
N
M
Q
N
T
M
G
Q
V
T
T
S
A
-------
E
Q
M
L
K
G
H
K
E
V
L
I
F
G
G
Q
E
V
E
T
K
R
F
D
K
V
S
N
K
M
R
L
Q
G
M
-
K
M
V
S
A
S
S
I
-
S
D
P
I
I
Q
L
I
A
S
L
A
L
A
F
V
L
Y
A
A
S
F
P
-
S
V
M
D
S
L
T
A
G
T
I
T
V
V
F
S
S
M
I
A
L
M
R
P
L
K
S
L
T
N
V
N
A
Q
F
Q
R
G
M
A
A
C
Q
T
L
F
A
I
L
D
S
E
Q
E
K
D
E
G
-----
K
----
R
V
I
D
R
A
T
G
D
---
L
E
F
R
N
V
T
F
T
Y
P
G
R
------
E
V
P
A
L
R
N
I
N
L
K
I
P
A
G
K
T
V
A
L
V
G
R
S
G
S
G
K
S
T
I
A
S
L
I
T
R
F
Y
D
I
D
E
G
H
I
L
M
D
G
H
D
L
R
E
Y
T
L
A
S
L
R
N
Q
V
A
L
V
S
Q
N
V
H
L
F
N
D
T
V
A
N
N
I
A
Y
A
R
T
E
E
---
Y
S
R
E
Q
I
E
E
A
A
R
M
A
Y
A
M
D
F
I
-
N
K
M
D
N
G
L
D
T
I
I
G
E
N
G
V
L
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
L
R
D
S
P
-
I
L
I
L
D
E
A
T
S
A
L
D
T
E
S
E
R
A
I
Q
A
A
L
D
E
L
Q
K
N
R
T
S
L
V
I
A
H
R
L
S
T
I
E
Q
A
D
E
I
V
V
V
E
D
G
I
I
V
E
R
G
T
H
S
E
L
L
A
Q
H
-
G
V
Y
A
Q
----------
9
PsiBlast_PDB
71.48
24%
-
- C1 -
-
3B5X
-
MSBA_VIBCH
A:
[14-581]
----
K
R
L
W
T
Y
I
R
L
Y
---
K
A
G
L
V
V
S
T
I
A
L
V
-
I
N
A
A
A
D
T
Y
M
I
S
L
L
K
P
L
L
D
E
G
F
G
N
A
E
-------
S
--
N
F
L
R
I
L
P
F
M
I
---
L
G
-
L
-
M
F
V
R
G
L
S
G
F
A
S
S
Y
C
L
S
W
V
S
G
N
V
V
M
----
Q
M
R
R
R
L
F
N
H
F
M
H
M
P
V
R
F
F
D
Q
E
S
T
G
G
L
L
S
R
I
T
Y
D
S
E
Q
V
A
G
A
T
-
S
R
A
L
V
S
I
V
R
E
G
A
S
I
I
G
L
L
T
L
M
F
-
W
N
S
W
Q
L
S
L
V
L
I
V
V
A
P
V
V
A
F
A
I
S
F
V
S
K
R
F
R
K
I
S
R
N
M
Q
T
A
M
G
H
V
T
S
S
A
-------
E
Q
M
L
K
G
H
K
V
V
L
S
Y
G
G
Q
E
V
E
R
K
R
F
D
K
V
S
N
S
M
R
Q
Q
T
M
-
K
L
V
S
A
Q
S
I
-
A
D
P
V
I
Q
M
I
A
S
L
A
L
F
A
V
L
F
L
A
S
V
D
S
I
-
R
A
E
L
T
P
G
T
F
T
V
V
F
S
A
M
F
G
L
M
R
P
L
K
A
L
T
S
V
T
S
E
F
Q
R
G
M
A
A
C
Q
T
L
F
G
L
M
-----
D
L
E
T
-----
E
-
R
D
-
N
G
K
Y
E
A
E
R
V
N
G
E
V
D
V
K
D
V
T
F
T
Y
Q
G
K
------
E
K
P
A
L
S
H
V
S
F
S
I
P
Q
G
K
T
V
A
L
V
G
R
S
G
S
G
K
S
T
I
A
N
L
F
T
R
F
Y
D
V
D
S
G
S
I
C
L
D
G
H
D
V
R
D
Y
K
L
T
N
L
R
R
H
F
A
L
V
S
Q
N
V
H
L
F
N
D
T
I
A
N
N
I
A
Y
A
A
E
G
E
---
Y
T
R
E
Q
I
E
Q
A
A
R
Q
A
H
A
M
E
F
I
-
E
N
M
P
Q
G
L
D
T
V
I
G
E
N
G
T
S
L
S
G
G
Q
R
Q
R
V
A
I
A
R
A
L
L
R
D
A
P
-
V
L
I
L
D
E
A
T
S
A
L
D
T
E
S
E
R
A
I
Q
A
A
L
D
E
L
Q
K
N
K
T
V
L
V
I
A
H
R
L
S
T
I
E
Q
A
D
E
I
L
V
V
D
E
G
E
I
I
E
R
G
R
H
A
D
L
L
A
Q
D
-
G
A
Y
A
Q
L
H
R
I
Q
F
G
---
8
PsiBlast_PDB
71.44
26%
-12
- C1 -
-
3B60
2
MSBA_SALTY
A:
[14-581]
----
R
R
L
W
P
T
I
A
P
F
---
K
A
G
L
I
V
A
G
I
A
L
I
-
L
N
A
A
S
D
T
F
M
L
S
L
L
K
P
L
L
D
D
G
F
G
K
T
D
-------
R
--
S
V
L
L---
W
M
P
L
V
V
I
G
-
L
-
M
I
L
R
G
I
T
S
Y
I
S
S
Y
C
I
S
W
V
S
G
K
V
V
M
----
T
M
R
R
R
L
F
G
H
M
M
G
M
P
V
A
F
F
D
K
Q
S
T
G
T
L
L
S
R
I
T
Y
D
S
E
Q
V
A
S
S
S
-
S
G
A
L
I
T
V
V
R
E
G
A
S
I
I
G
L
F
I
M
M
F
-
Y
Y
S
W
Q
L
S
I
I
L
V
V
L
A
P
I
V
S
I
A
I
R
V
V
S
K
R
F
R
S
I
S
K
N
M
Q
N
T
M
G
Q
V
T
T
S
A
-------
E
Q
M
L
K
G
H
K
E
V
L
I
F
G
G
Q
E
V
E
T
K
R
F
D
K
V
S
N
-
K
M
R
L
Q
G
M
K
M
V
S
A
S
S
I
-
S
D
P
I
I
Q
L
I
A
S
L
A
L
A
F
V
L
Y
A
A
S
F
P
S
V
-
M
D
S
L
T
A
G
T
I
T
V
V
F
S
S
M
I
A
L
M
R
P
L
K
S
L
T
N
V
N
A
Q
F
Q
R
G
M
A
A
C
Q
T
L
F
A
I
L
D
S
E
Q
E
K
D
E
G
-----
K
-
R
V
-
I
D
R
A
T
G
D
-----
L
E
F
R
N
V
T
F
T
Y
P
G
R
------
E
V
P
A
L
R
N
I
N
L
K
I
P
A
G
K
T
V
A
L
V
G
R
S
G
S
G
K
S
T
I
A
S
L
I
T
R
F
Y
D
I
D
E
G
H
I
L
M
D
G
H
D
L
R
E
Y
T
L
A
S
L
R
N
Q
V
A
L
V
S
Q
N
V
H
L
F
N
D
T
V
A
N
N
I
A
Y
A
R
T
E
E
---
Y
S
R
E
Q
I
E
E
A
A
R
M
A
Y
A
M
D
F
I
-
N
K
M
D
N
G
L
D
T
I
I
G
E
N
G
V
L
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
L
R
D
S
P
-
I
L
I
L
D
E
A
T
S
A
L
D
T
E
S
E
R
A
I
Q
A
A
L
D
E
L
Q
K
N
R
T
S
L
V
I
A
H
R
L
S
T
I
E
Q
A
D
E
I
V
V
V
E
D
G
I
I
V
E
R
G
T
H
S
E
L
L
A
Q
H
-
G
V
Y
A
Q
L
H
K
M
Q
F
G
---
14
PsiBlast_PDB
71.39
26%
-19
- C1 -
-
4A82
-
Y1866_STAAM
A:
[2-577]
---
I
K
R
Y
L
Q
F
V
K
P
Y
K
Y
R
I
F
A
T
I
I
V
G
I
I
K
F
G
I
P
M
L
I
P
L
L
I
K
Y
A
I
D
G
V
I
N
N
H
A
L
T
T
D
-------
E
K
V
H
H
L
----
T
I
A
---
I
G
-
I
A
L
F
I
F
V
I
V
R
P
P
I
E
F
I
R
Q
Y
L
A
Q
W
T
S
N
K
I
L
Y
D
I
R
K
K
L
Y
N
H
L
Q
A
L
S
A
R
F
Y
A
N
N
Q
V
G
Q
V
I
S
R
V
I
N
D
V
E
Q
T
K
D
F
I
L
T
G
L
M
N
I
W
L
D
C
I
T
I
I
I
A
L
S
I
M
F
F
L
D
V
K
L
T
L
A
A
L
F
I
F
P
F
Y
I
L
T
V
Y
V
---------
F
F
G
R
L
R
K
L
T
R
E
R
S
Q
A
L
A
E
V
Q
G
F
L
H
E
R
V
Q
G
I
S
V
V
K
S
F
A
I
E
D
N
E
A
K
N
F
D
K
K
N
T
N
F
L
T
R
A
L
-
K
H
T
R
W
N
A
Y
S
F
A
A
I
N
T
V
T
D
I
G
P
I
I
V
I
G
V
G
A
Y
L
A
I
S
-
G
S
I
-
T
V
G
T
L
A
A
F
V
G
Y
L
E
L
L
F
G
P
L
R
R
L
V
A
S
F
T
T
L
T
Q
S
F
A
S
M
D
R
V
F
Q
L
-
I
D
E
D
Y
D
I
K
N
GVGAQ
P
-
I
E
-
I
K
Q
G
R
I
D
-------
I
D
H
V
S
F
Q
Y
N
D
N
------
E
A
P
I
L
K
D
I
N
L
S
I
E
K
G
E
T
V
A
F
V
G
M
S
G
G
G
K
S
T
L
I
N
L
I
P
R
F
Y
D
V
T
S
G
Q
I
L
I
D
G
H
N
I
K
D
F
L
T
G
S
L
R
N
Q
I
G
L
V
Q
Q
D
N
I
L
F
S
D
T
V
K
E
N
I
L
L
G
-
R
P
T
---
A
T
D
E
E
V
V
E
A
A
K
M
A
N
A
H
D
F
I
-
M
N
L
P
Q
G
Y
D
T
E
V
G
E
R
G
V
K
L
S
G
G
Q
K
Q
R
L
S
I
A
R
I
F
L
N
N
P
P
-
I
L
I
L
D
E
A
T
S
A
L
D
L
E
S
E
S
I
I
Q
E
A
L
D
V
L
S
K
D
R
T
T
L
I
V
A
H
R
L
S
T
I
T
H
A
D
K
I
V
V
I
E
N
G
H
I
V
E
T
G
T
H
R
E
L
I
A
K
Q
-
G
A
Y
E
H
L
Y
S
I
Q
N
----