@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : spr1229: (2018-01-07 )
MKLKTNIRHLHGSIRVPGDKSISHRSIIFGSLAEGETKVYDILRGEDVLSTMQVFRDLGVEIEDKDGVITIQGVGMAGLKAPQNALNMGNSGTSIRLISGVLAGADFEVEMFGDDSLSKRPMDRVTLPLKKMGVSISGQTERDLPPLRLKGTKNLRPIHYELPIASAQVKSALMFAALQAKGESVIIEKECTRNHTEDMLKQFGGHLSVDGKKITVQGPQKLTGQKVVVPGDISSAAFWLVAGLINPNSHLVLQNVGINETRTGIIDVIRAMGGKLEVTEIDPVAKSSTLTVESSDLKGTEIGGALIPRLIDELPIIALLATQAQGVTVIKDAEELKVKETDRIQVVADALNSMGADITPTADGMIIKGKSALHGARVNTFGDHRIGMMTAIAALLVADGEVELDRAEAINTSYPSFFDDLESLIHG
Atome Classification :
(28 SA)
......-...10........20........30........40........50........60..--.-..-...70........80........90........100.......110.......120.......130.......140.......150.......160--.......170.......180.......190.......200.......----210----........220.......230.......240.......250.......260.......270.......280.-.--.-.--.----..--290..-.....300.......310.......320.......330.......340.......350.......360.......370----.---.-------.---......380.......390.....-..400.......410.......420.....
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MKLKTN-
I
R
H
L
H
G
S
I
RVPGDKSISHR
S
I
I
F
G
SLAEGE
T
K
V
Y
D
I
LR
G
E
D
V
L
S
T
M
Q
V
F
R
DLG
V
E
I
E--D-KD-
G
V
I
T
I
Q
GVGMAGLKAP
Q
N
A
LNMGNSG
T
S
I
R
L
I
S
G
V
LAGA
D
F
E
V
E
M
FGDDSLSKRPM
D
R
VTL
P
L
K
KM
G
V
SISGQTERDLP
P
L
RLKGTKNLR
P
I
H
Y
EL--PI
A
S
A
Q
V
K
S
A
L
M
F
A
A
L
QAKG
E
S
V
I
I
E
K
E
CTRN
H
T
E
D
M
L
K
QFGG
H
L
S
V----DG-----
K
K
I
T
VQGPQKLTG
Q
K
V
V
VPGDI
S
S
A
A
F
W
L
V
A
G
LINPN
S
H
L
V
L
Q
NVGINET
R
T
G
I
I
D
V
I
R
AMGG
K
L
E
V
T
E
IDP-V--A-K--S----
S
T
--
L
T
V
ES-SDLKGTEI
G
G
A
L
I
P
R
L
I
D
EL
P
I
I
A
L
L
ATQAQ
G
V
T
V
IK
D
A
E
ELKVKETD
R
I
Q
V
V
A
D
A
L
N
SMGADITPTAD
G
M
I
I
KGK------S---A-------L---HGARVNTFGDH
R
I
G
M
M
T
A
I
A
A
L
L
V-ADG
E
V
E
L
D
R
A
EAINTSY
P
S
F
F
D
D
L
E
S
L
IHG
2
PsiBlast_PDB
97.32
97%
-106
- C7 -
-
1RF5
-
AROA_STRPN
A:
[1-427]
M
K
L
K
T
N
-
I
R
H
L
H
G
I
I
R
V
P
G
D
K
S
I
S
H
R
S
I
I
F
G
S
L
A
E
G
E
T
K
V
Y
D
I
L
R
G
E
D
V
L
S
T
M
Q
V
F
R
D
L
G
V
E
I
E
--
D
-
K
D
-
G
V
I
T
V
Q
G
V
G
M
A
G
L
K
A
P
Q
N
A
L
N
M
G
N
S
G
T
S
I
R
L
I
S
G
V
L
A
G
A
D
F
E
V
E
M
F
G
D
D
S
L
S
K
R
P
M
D
R
V
T
L
P
L
K
K
M
G
V
S
I
S
G
Q
T
E
R
D
L
P
P
L
R
L
K
G
T
K
N
L
R
P
I
H
Y
E
L
--
P
I
A
S
A
Q
V
K
S
A
L
M
F
A
A
L
Q
A
K
G
E
S
V
I
I
E
K
E
Y
T
R
N
H
T
E
D
M
L
Q
Q
F
G
G
H
L
S
V
----
D
G
-----
K
K
I
T
V
Q
G
P
Q
K
L
T
G
Q
K
V
V
V
P
G
D
I
S
S
A
A
F
W
L
V
A
G
L
I
A
P
N
S
R
L
V
L
Q
N
V
G
I
N
E
T
R
T
G
I
I
D
V
I
R
A
M
G
G
K
L
E
I
T
E
I
D
P
-
V
--
A
-
K
--
S
----
A
T
--
L
I
V
E
S
-
S
D
L
K
G
T
E
I
C
G
A
L
I
P
R
L
I
D
E
L
P
I
I
A
L
L
A
T
Q
A
Q
G
V
T
V
I
K
D
A
E
E
L
K
V
K
E
T
D
R
I
Q
V
V
A
D
A
L
N
S
M
G
A
D
I
T
P
T
A
D
G
M
I
I
K
G
K
------
S
---
A
-------
L
---
H
G
A
R
V
N
T
F
G
D
H
R
I
G
M
M
T
A
I
A
A
L
L
V
-
A
D
G
E
V
E
L
D
R
A
E
A
I
N
T
S
Y
P
S
F
F
D
D
L
E
S
L
I
H
G
3
PsiBlast_PDB
95.65
97%
-96
- C7 -
-
1RF6
2
AROA_STRPN
A:
[1-427]
M
K
L
K
T
N
-
I
R
H
L
H
G
I
I
R
V
P
G
D
K
S
I
S
H
R
S
I
I
F
G
S
L
A
E
G
E
T
K
V
Y
D
I
L
R
G
E
D
V
L
S
T
M
Q
V
F
R
D
L
G
V
E
I
E
--
D
-
K
D
-
G
V
I
T
V
Q
G
V
G
M
A
G
L
K
A
P
Q
N
A
L
N
M
G
N
S
G
T
S
I
R
L
I
S
G
V
L
A
G
A
D
F
E
V
E
M
F
G
D
D
S
L
S
K
R
P
M
D
R
V
T
L
P
L
K
K
M
G
V
S
I
S
G
Q
T
E
R
D
L
P
P
L
R
L
K
G
T
K
N
L
R
P
I
H
Y
E
L
--
P
I
A
S
A
Q
V
K
S
A
L
M
F
A
A
L
Q
A
K
G
E
S
V
I
I
E
K
E
Y
T
R
N
H
T
E
D
M
L
Q
Q
F
G
G
H
L
S
V
----
D
G
-----
K
K
I
T
V
Q
G
P
Q
K
L
T
G
Q
K
V
V
V
P
G
D
I
S
S
A
A
F
W
L
V
A
G
L
I
A
P
N
S
R
L
V
L
Q
N
V
G
I
N
E
T
R
T
G
I
I
D
V
I
R
A
M
G
G
K
L
E
I
T
E
I
D
P
-
V
--
A
-
K
--
S
----
A
T
--
L
I
V
E
S
-
S
D
L
K
G
T
E
I
C
G
A
L
I
P
R
L
I
D
E
L
P
I
I
A
L
L
A
T
Q
A
Q
G
V
T
V
I
K
D
A
E
E
L
K
V
K
E
T
D
R
I
Q
V
V
A
D
A
L
N
S
M
G
A
D
I
T
P
T
A
D
G
M
I
I
K
G
K
------
S
---
A
-------
L
---
H
G
A
R
V
N
T
F
G
D
H
R
I
G
M
M
T
A
I
A
A
L
L
V
-
A
D
G
E
V
E
L
D
R
A
E
A
I
N
T
S
Y
P
S
F
F
D
D
L
E
S
L
I
H
G
23
PsiBlast_CBE
95.48
97%
-95
- C7 -
-
1RF6
2
AROA_STRPN
B:
[1-427]
M
K
L
K
T
N
-
I
R
H
L
H
G
I
I
R
V
P
G
D
K
S
I
S
H
R
S
I
I
F
G
S
L
A
E
G
E
T
K
V
Y
D
I
L
R
G
E
D
V
L
S
T
M
Q
V
F
R
D
L
G
V
E
I
E
--
D
-
K
D
-
G
V
I
T
V
Q
G
V
G
M
A
G
L
K
A
P
Q
N
A
L
N
M
G
N
S
G
T
S
I
R
L
I
S
G
V
L
A
G
A
D
F
E
V
E
M
F
G
D
D
S
L
S
K
R
P
M
D
R
V
T
L
P
L
K
K
M
G
V
S
I
S
G
Q
T
E
R
D
L
P
P
L
R
L
K
G
T
K
N
L
R
P
I
H
Y
E
L
--
P
I
A
S
A
Q
V
K
S
A
L
M
F
A
A
L
Q
A
K
G
E
S
V
I
I
E
K
E
Y
T
R
N
H
T
E
D
M
L
Q
Q
F
G
G
H
L
S
V
----
D
G
-----
K
K
I
T
V
Q
G
P
Q
K
L
T
G
Q
K
V
V
V
P
G
D
I
S
S
A
A
F
W
L
V
A
G
L
I
A
P
N
S
R
L
V
L
Q
N
V
G
I
N
E
T
R
T
G
I
I
D
V
I
R
A
M
G
G
K
L
E
I
T
E
I
D
P
-
V
--
A
-
K
--
S
----
A
T
--
L
I
V
E
S
-
S
D
L
K
G
T
E
I
C
G
A
L
I
P
R
L
I
D
E
L
P
I
I
A
L
L
A
T
Q
A
Q
G
V
T
V
I
K
D
A
E
E
L
K
V
K
E
T
D
R
I
Q
V
V
A
D
A
L
N
S
M
G
A
D
I
T
P
T
A
D
G
M
I
I
K
G
K
------
S
---
A
-------
L
---
H
G
A
R
V
N
T
F
G
D
H
R
I
G
M
M
T
A
I
A
A
L
L
V
-
A
D
G
E
V
E
L
D
R
A
E
A
I
N
T
S
Y
P
S
F
F
D
D
L
E
S
L
I
H
G
4
PsiBlast_PDB
95.10
92%
-107
- C7 -
-
4N3P
-
?
A:
[3-428]
-
K
L
K
T
N
-
I
R
H
L
H
G
I
I
R
V
P
G
D
S
S
I
S
V
L
S
I
I
F
G
S
L
A
E
G
E
T
K
V
Y
D
I
L
R
G
E
D
V
L
S
T
M
Q
V
F
R
D
L
G
V
E
I
E
--
D
-
K
D
-
G
V
I
T
V
Q
G
V
G
M
A
G
L
K
A
P
Q
N
A
L
N
M
G
N
S
G
A
S
I
V
A
I
S
G
V
L
A
G
A
D
F
E
V
E
M
F
G
D
D
S
L
S
K
R
P
M
D
R
V
T
L
P
L
K
K
M
G
V
S
I
S
G
Q
T
E
R
D
L
P
P
L
R
L
K
G
T
K
N
L
R
P
I
H
Y
E
L
--
P
I
A
S
N
S
V
K
S
A
L
M
F
A
A
L
Q
A
K
G
E
S
V
I
I
E
K
E
Y
T
S
N
H
T
E
D
M
L
Q
Q
F
G
G
H
L
S
V
----
D
G
-----
K
K
I
T
V
Q
G
P
Q
K
L
T
G
Q
K
V
V
V
P
G
D
I
S
S
A
A
F
W
L
V
A
G
L
I
A
P
N
S
R
L
V
L
Q
N
V
G
I
E
E
T
L
T
G
I
I
D
V
I
R
A
M
G
G
K
L
E
I
T
E
I
D
P
-
V
--
A
-
K
--
S
----
A
T
--
L
I
V
E
S
-
S
D
L
K
G
T
E
I
C
G
A
L
I
P
R
L
I
D
E
L
P
I
I
A
L
L
A
T
Q
A
Q
G
V
T
V
I
K
D
A
E
E
L
K
V
K
E
T
D
R
I
Q
V
V
A
D
A
L
N
S
M
G
A
D
I
T
P
T
A
D
G
M
I
I
K
G
K
------
S
---
A
-------
L
---
H
G
A
R
V
N
T
F
G
D
H
R
I
G
M
M
T
A
I
A
A
L
L
V
-
A
D
G
E
V
E
L
D
R
A
E
A
I
----
P
S
F
F
D
D
L
E
S
L
I
H
G
21
PsiBlast_CBE
94.76
97%
-95
- C7 -
-
1RF6
2
AROA_STRPN
D:
[1-427]
M
K
L
K
T
N
-
I
R
H
L
H
G
I
I
R
V
P
G
D
K
S
I
S
H
R
S
I
I
F
G
S
L
A
E
G
E
T
K
V
Y
D
I
L
R
G
E
D
V
L
S
T
M
Q
V
F
R
D
L
G
V
E
I
E
--
D
-
K
D
-
G
V
I
T
V
Q
G
V
G
M
A
G
L
K
A
P
Q
N
A
L
N
M
G
N
S
G
T
S
I
R
L
I
S
G
V
L
A
G
A
D
F
E
V
E
M
F
G
D
D
S
L
S
K
R
P
M
D
R
V
T
L
P
L
K
K
M
G
V
S
I
S
G
Q
T
E
R
D
L
P
P
L
R
L
K
G
T
K
N
L
R
P
I
H
Y
E
L
--
P
I
A
S
A
Q
V
K
S
A
L
M
F
A
A
L
Q
A
K
G
E
S
V
I
I
E
K
E
Y
T
R
N
H
T
E
D
M
L
Q
Q
F
G
G
H
L
S
V
----
D
G
-----
K
K
I
T
V
Q
G
P
Q
K
L
T
G
Q
K
V
V
V
P
G
D
I
S
S
A
A
F
W
L
V
A
G
L
I
A
P
N
S
R
L
V
L
Q
N
V
G
I
N
E
T
R
T
G
I
I
D
V
I
R
A
M
G
G
K
L
E
I
T
E
I
D
P
-
V
--
A
-
K
--
S
----
A
T
--
L
I
V
E
S
-
S
D
L
K
G
T
E
I
C
G
A
L
I
P
R
L
I
D
E
L
P
I
I
A
L
L
A
T
Q
A
Q
G
V
T
V
I
K
D
A
E
E
L
K
V
K
E
T
D
R
I
Q
V
V
A
D
A
L
N
S
M
G
A
D
I
T
P
T
A
D
G
M
I
I
K
G
K
------
S
---
A
-------
L
---
H
G
A
R
V
N
T
F
G
D
H
R
I
G
M
M
T
A
I
A
A
L
L
V
-
A
D
G
E
V
E
L
D
R
A
E
A
I
N
T
S
Y
P
S
F
F
D
D
L
E
S
L
I
H
G
22
PsiBlast_CBE
94.42
97%
-94
- C7 -
-
1RF6
2
AROA_STRPN
C:
[1-427]
M
K
L
K
T
N
-
I
R
H
L
H
G
I
I
R
V
P
G
D
K
S
I
S
H
R
S
I
I
F
G
S
L
A
E
G
E
T
K
V
Y
D
I
L
R
G
E
D
V
L
S
T
M
Q
V
F
R
D
L
G
V
E
I
E
--
D
-
K
D
-
G
V
I
T
V
Q
G
V
G
M
A
G
L
K
A
P
Q
N
A
L
N
M
G
N
S
G
T
S
I
R
L
I
S
G
V
L
A
G
A
D
F
E
V
E
M
F
G
D
D
S
L
S
K
R
P
M
D
R
V
T
L
P
L
K
K
M
G
V
S
I
S
G
Q
T
E
R
D
L
P
P
L
R
L
K
G
T
K
N
L
R
P
I
H
Y
E
L
--
P
I
A
S
A
Q
V
K
S
A
L
M
F
A
A
L
Q
A
K
G
E
S
V
I
I
E
K
E
Y
T
R
N
H
T
E
D
M
L
Q
Q
F
G
G
H
L
S
V
----
D
G
-----
K
K
I
T
V
Q
G
P
Q
K
L
T
G
Q
K
V
V
V
P
G
D
I
S
S
A
A
F
W
L
V
A
G
L
I
A
P
N
S
R
L
V
L
Q
N
V
G
I
N
E
T
R
T
G
I
I
D
V
I
R
A
M
G
G
K
L
E
I
T
E
I
D
P
-
V
--
A
-
K
--
S
----
A
T
--
L
I
V
E
S
-
S
D
L
K
G
T
E
I
C
G
A
L
I
P
R
L
I
D
E
L
P
I
I
A
L
L
A
T
Q
A
Q
G
V
T
V
I
K
D
A
E
E
L
K
V
K
E
T
D
R
I
Q
V
V
A
D
A
L
N
S
M
G
A
D
I
T
P
T
A
D
G
M
I
I
K
G
K
------
S
---
A
-------
L
---
H
G
A
R
V
N
T
F
G
D
H
R
I
G
M
M
T
A
I
A
A
L
L
V
-
A
D
G
E
V
E
L
D
R
A
E
A
I
N
T
S
Y
P
S
F
F
D
D
L
E
S
L
I
H
G
1
PsiBlast_PDB
94.32
97%
-93
- C7 -
-
1RF4
1
AROA_STRPN
A:
[1-427]
M
K
L
K
T
N
-
I
R
H
L
H
G
I
I
R
V
P
G
D
K
S
I
S
H
R
S
I
I
F
G
S
L
A
E
G
E
T
K
V
Y
D
I
L
R
G
E
D
V
L
S
T
M
Q
V
F
R
D
L
G
V
E
I
E
--
D
-
K
D
-
G
V
I
T
V
Q
G
V
G
M
A
G
L
K
A
P
Q
N
A
L
N
M
G
N
S
G
T
S
I
R
L
I
S
G
V
L
A
G
A
D
F
E
V
E
M
F
G
D
D
S
L
S
K
R
P
M
D
R
V
T
L
P
L
K
K
M
G
V
S
I
S
G
Q
T
E
R
D
L
P
P
L
R
L
K
G
T
K
N
L
R
P
I
H
Y
E
L
--
P
I
A
S
A
Q
V
K
S
A
L
M
F
A
A
L
Q
A
K
G
E
S
V
I
I
E
K
E
Y
T
R
N
H
T
E
D
M
L
Q
Q
F
G
G
H
L
S
V
----
D
G
-----
K
K
I
T
V
Q
G
P
Q
K
L
T
G
Q
K
V
V
V
P
G
D
I
S
S
A
A
F
W
L
V
A
G
L
I
A
P
N
S
R
L
V
L
Q
N
V
G
I
N
E
T
R
T
G
I
I
D
V
I
R
A
M
G
G
K
L
E
I
T
E
I
D
P
-
V
--
A
-
K
--
S
----
A
T
--
L
I
V
E
S
-
S
D
L
K
G
T
E
I
C
G
A
L
I
P
R
L
I
D
E
L
P
I
I
A
L
L
A
T
Q
A
Q
G
V
T
V
I
K
D
A
E
E
L
K
V
K
E
T
D
R
I
Q
V
V
A
D
A
L
N
S
M
G
A
D
I
T
P
T
A
D
G
M
I
I
K
G
K
------
S
---
A
-------
L
---
H
G
A
R
V
N
T
F
G
D
H
R
I
G
M
M
T
A
I
A
A
L
L
V
-
A
D
G
E
V
E
L
D
R
A
E
A
I
N
T
S
Y
P
S
F
F
D
D
L
E
S
L
I
H
G
25
PsiBlast_CBE
94.30
97%
-94
- C7 -
-
1RF4
1
AROA_STRPN
C:
[1-427]
M
K
L
K
T
N
-
I
R
H
L
H
G
I
I
R
V
P
G
D
K
S
I
S
H
R
S
I
I
F
G
S
L
A
E
G
E
T
K
V
Y
D
I
L
R
G
E
D
V
L
S
T
M
Q
V
F
R
D
L
G
V
E
I
E
--
D
-
K
D
-
G
V
I
T
V
Q
G
V
G
M
A
G
L
K
A
P
Q
N
A
L
N
M
G
N
S
G
T
S
I
R
L
I
S
G
V
L
A
G
A
D
F
E
V
E
M
F
G
D
D
S
L
S
K
R
P
M
D
R
V
T
L
P
L
K
K
M
G
V
S
I
S
G
Q
T
E
R
D
L
P
P
L
R
L
K
G
T
K
N
L
R
P
I
H
Y
E
L
--
P
I
A
S
A
Q
V
K
S
A
L
M
F
A
A
L
Q
A
K
G
E
S
V
I
I
E
K
E
Y
T
R
N
H
T
E
D
M
L
Q
Q
F
G
G
H
L
S
V
----
D
G
-----
K
K
I
T
V
Q
G
P
Q
K
L
T
G
Q
K
V
V
V
P
G
D
I
S
S
A
A
F
W
L
V
A
G
L
I
A
P
N
S
R
L
V
L
Q
N
V
G
I
N
E
T
R
T
G
I
I
D
V
I
R
A
M
G
G
K
L
E
I
T
E
I
D
P
-
V
--
A
-
K
--
S
----
A
T
--
L
I
V
E
S
-
S
D
L
K
G
T
E
I
C
G
A
L
I
P
R
L
I
D
E
L
P
I
I
A
L
L
A
T
Q
A
Q
G
V
T
V
I
K
D
A
E
E
L
K
V
K
E
T
D
R
I
Q
V
V
A
D
A
L
N
S
M
G
A
D
I
T
P
T
A
D
G
M
I
I
K
G
K
------
S
---
A
-------
L
---
H
G
A
R
V
N
T
F
G
D
H
R
I
G
M
M
T
A
I
A
A
L
L
V
-
A
D
G
E
V
E
L
D
R
A
E
A
I
N
T
S
Y
P
S
F
F
D
D
L
E
S
L
I
H
G
24
PsiBlast_CBE
94.29
97%
-95
- C7 -
-
1RF4
1
AROA_STRPN
D:
[1-427]
M
K
L
K
T
N
-
I
R
H
L
H
G
I
I
R
V
P
G
D
K
S
I
S
H
R
S
I
I
F
G
S
L
A
E
G
E
T
K
V
Y
D
I
L
R
G
E
D
V
L
S
T
M
Q
V
F
R
D
L
G
V
E
I
E
--
D
-
K
D
-
G
V
I
T
V
Q
G
V
G
M
A
G
L
K
A
P
Q
N
A
L
N
M
G
N
S
G
T
S
I
R
L
I
S
G
V
L
A
G
A
D
F
E
V
E
M
F
G
D
D
S
L
S
K
R
P
M
D
R
V
T
L
P
L
K
K
M
G
V
S
I
S
G
Q
T
E
R
D
L
P
P
L
R
L
K
G
T
K
N
L
R
P
I
H
Y
E
L
--
P
I
A
S
A
Q
V
K
S
A
L
M
F
A
A
L
Q
A
K
G
E
S
V
I
I
E
K
E
Y
T
R
N
H
T
E
D
M
L
Q
Q
F
G
G
H
L
S
V
----
D
G
-----
K
K
I
T
V
Q
G
P
Q
K
L
T
G
Q
K
V
V
V
P
G
D
I
S
S
A
A
F
W
L
V
A
G
L
I
A
P
N
S
R
L
V
L
Q
N
V
G
I
N
E
T
R
T
G
I
I
D
V
I
R
A
M
G
G
K
L
E
I
T
E
I
D
P
-
V
--
A
-
K
--
S
----
A
T
--
L
I
V
E
S
-
S
D
L
K
G
T
E
I
C
G
A
L
I
P
R
L
I
D
E
L
P
I
I
A
L
L
A
T
Q
A
Q
G
V
T
V
I
K
D
A
E
E
L
K
V
K
E
T
D
R
I
Q
V
V
A
D
A
L
N
S
M
G
A
D
I
T
P
T
A
D
G
M
I
I
K
G
K
------
S
---
A
-------
L
---
H
G
A
R
V
N
T
F
G
D
H
R
I
G
M
M
T
A
I
A
A
L
L
V
-
A
D
G
E
V
E
L
D
R
A
E
A
I
N
T
S
Y
P
S
F
F
D
D
L
E
S
L
I
H
G
26
PsiBlast_CBE
94.18
97%
-94
- C7 -
-
1RF4
1
AROA_STRPN
B:
[1-427]
M
K
L
K
T
N
-
I
R
H
L
H
G
I
I
R
V
P
G
D
K
S
I
S
H
R
S
I
I
F
G
S
L
A
E
G
E
T
K
V
Y
D
I
L
R
G
E
D
V
L
S
T
M
Q
V
F
R
D
L
G
V
E
I
E
--
D
-
K
D
-
G
V
I
T
V
Q
G
V
G
M
A
G
L
K
A
P
Q
N
A
L
N
M
G
N
S
G
T
S
I
R
L
I
S
G
V
L
A
G
A
D
F
E
V
E
M
F
G
D
D
S
L
S
K
R
P
M
D
R
V
T
L
P
L
K
K
M
G
V
S
I
S
G
Q
T
E
R
D
L
P
P
L
R
L
K
G
T
K
N
L
R
P
I
H
Y
E
L
--
P
I
A
S
A
Q
V
K
S
A
L
M
F
A
A
L
Q
A
K
G
E
S
V
I
I
E
K
E
Y
T
R
N
H
T
E
D
M
L
Q
Q
F
G
G
H
L
S
V
----
D
G
-----
K
K
I
T
V
Q
G
P
Q
K
L
T
G
Q
K
V
V
V
P
G
D
I
S
S
A
A
F
W
L
V
A
G
L
I
A
P
N
S
R
L
V
L
Q
N
V
G
I
N
E
T
R
T
G
I
I
D
V
I
R
A
M
G
G
K
L
E
I
T
E
I
D
P
-
V
--
A
-
K
--
S
----
A
T
--
L
I
V
E
S
-
S
D
L
K
G
T
E
I
C
G
A
L
I
P
R
L
I
D
E
L
P
I
I
A
L
L
A
T
Q
A
Q
G
V
T
V
I
K
D
A
E
E
L
K
V
K
E
T
D
R
I
Q
V
V
A
D
A
L
N
S
M
G
A
D
I
T
P
T
A
D
G
M
I
I
K
G
K
------
S
---
A
-------
L
---
H
G
A
R
V
N
T
F
G
D
H
R
I
G
M
M
T
A
I
A
A
L
L
V
-
A
D
G
E
V
E
L
D
R
A
E
A
I
N
T
S
Y
P
S
F
F
D
D
L
E
S
L
I
H
G
49
HHSearch
92.85
97%
-84
- C7 -
-
1RF6
2
AROA_STRPN
C:
[1-427]
M
K
L
K
T
N
-
I
R
H
L
H
G
I
I
R
V
P
G
D
K
S
I
S
H
R
S
I
I
F
G
S
L
A
E
G
E
T
K
V
Y
D
I
L
R
G
E
D
V
L
S
T
M
Q
V
F
R
D
L
G
V
E
I
E
--
D
-
K
D
-
G
V
I
T
V
Q
G
V
G
M
A
G
L
K
A
P
Q
N
A
L
N
M
G
N
S
G
T
S
I
R
L
I
S
G
V
L
A
G
A
D
F
E
V
E
M
F
G
D
D
S
L
S
K
R
P
M
D
R
V
T
L
P
L
K
K
M
G
V
S
I
S
G
Q
T
E
R
D
L
P
P
L
R
L
K
G
T
K
N
L
R
P
I
H
Y
E
L
--
P
I
A
S
A
Q
V
K
S
A
L
M
F
A
A
L
Q
A
K
G
E
S
V
I
I
E
K
E
Y
T
R
N
H
T
E
D
M
L
Q
Q
F
G
G
H
L
S
V
----
D
G
-----
K
K
I
T
V
Q
G
P
Q
K
L
T
G
Q
K
V
V
V
P
G
D
I
S
S
A
A
F
W
L
V
A
G
L
I
A
P
N
S
R
L
V
L
Q
N
V
G
I
N
E
T
R
T
G
I
I
D
V
I
R
A
M
G
G
K
L
E
I
T
E
I
D
P
-
V
--
A
-
K
--
S
----
A
T
--
L
I
V
E
S
-
S
D
L
K
G
T
E
I
C
G
A
L
I
P
R
L
I
D
E
L
P
I
I
A
L
L
A
T
Q
A
Q
G
V
T
V
I
K
D
A
E
E
L
K
V
K
E
T
D
R
I
Q
V
V
A
D
A
L
N
S
M
G
A
D
I
T
P
T
A
D
G
M
I
I
K
G
K
------
S
---
A
-------
L
---
H
G
A
R
V
N
T
F
G
D
H
R
I
G
M
M
T
A
I
A
A
L
-
L
V
A
D
G
E
V
E
L
D
R
A
E
A
I
N
T
S
Y
P
S
F
F
D
D
L
E
S
L
I
H
G
54
HHSearch
66.05
43%
-11
- C7 -
-
3SLH
4
AROA_COXBU
B:
[9-431]
----
I
P
-
S
Q
G
L
S
G
E
I
C
V
P
G
D
K
S
I
S
H
R
A
V
L
L
A
A
I
A
E
G
Q
T
Q
V
D
G
F
L
M
G
A
D
N
L
A
M
V
S
A
L
Q
Q
M
G
A
S
I
Q
--
V
I
E
D
E
N
I
L
V
V
E
G
V
G
M
T
G
L
Q
A
P
P
E
A
L
D
C
G
N
S
G
T
A
I
R
L
L
S
G
L
L
A
G
Q
P
F
N
T
V
L
T
G
D
S
S
L
Q
R
R
P
M
K
R
I
I
D
P
L
T
L
M
G
A
K
I
D
S
-
T
-
G
N
V
P
P
L
K
I
Y
G
N
P
R
L
T
G
I
H
Y
Q
L
--
P
M
A
S
A
Q
V
K
S
C
L
L
L
A
G
L
Y
A
R
G
K
T
C
I
T
E
P
A
P
S
R
D
H
T
E
R
L
L
K
H
F
H
Y
T
L
Q
K
----
D
K
-----
Q
S
I
C
V
S
G
G
G
K
L
K
A
N
D
I
S
I
P
G
D
I
S
S
A
A
F
F
I
V
A
A
T
I
T
P
G
S
A
I
R
L
C
R
V
G
V
N
P
T
R
L
G
V
I
N
L
L
K
M
M
G
A
D
I
E
V
T
H
Y
T
E
-
K
NE
E
-
P
--
T
----
A
D
--
I
T
V
R
H
-
A
R
L
K
G
I
D
I
P
P
D
Q
V
P
L
T
I
D
E
F
P
V
L
L
I
A
A
A
V
A
Q
G
K
T
V
L
R
D
A
A
E
L
R
V
K
E
T
D
R
I
A
A
M
V
D
G
L
Q
K
L
G
I
A
A
E
S
L
P
D
G
V
I
I
Q
G
G
------
T
-----------
L
---
E
G
G
E
V
N
S
Y
D
D
H
R
I
A
M
A
F
A
V
A
G
T
-
L
-
A
K
G
P
V
R
I
R
N
C
D
N
V
K
T
S
F
P
N
F
V
E
L
A
N
E
V
G
M
N
53
HHSearch
65.71
43%
-9
* C7 *
-
3SLH
16
AROA_COXBU
D:
[9-431]
----
I
P
-
S
Q
G
L
S
G
E
I
C
V
P
G
D
K
S
I
S
H
R
A
V
L
L
A
A
I
A
E
G
Q
T
Q
V
D
G
F
L
M
G
A
D
N
L
A
M
V
S
A
L
Q
Q
M
G
A
S
I
Q
--
V
I
E
D
E
N
I
L
V
V
E
G
V
G
M
T
G
L
Q
A
P
P
E
A
L
D
C
G
N
S
G
T
A
I
R
L
L
S
G
L
L
A
G
Q
P
F
N
T
V
L
T
G
D
S
S
L
Q
R
R
P
M
K
R
I
I
D
P
L
T
L
M
G
A
K
I
D
S
-
T
-
G
N
V
P
P
L
K
I
Y
G
N
P
R
L
T
G
I
H
Y
Q
L
--
P
M
A
S
A
Q
V
K
S
C
L
L
L
A
G
L
Y
A
R
G
K
T
C
I
T
E
P
A
P
S
R
D
H
T
E
R
L
L
K
H
F
H
Y
T
L
Q
K
----
D
K
-----
Q
S
I
C
V
S
G
G
G
K
L
K
A
N
D
I
S
I
P
G
D
I
S
S
A
A
F
F
I
V
A
A
T
I
T
P
G
S
A
I
R
L
C
R
V
G
V
N
P
T
R
L
G
V
I
N
L
L
K
M
M
G
A
D
I
E
V
T
H
Y
T
E
-
K
NE
E
-
P
--
T
----
A
D
--
I
T
V
R
H
-
A
R
L
K
G
I
D
I
P
P
D
Q
V
P
L
T
I
D
E
F
P
V
L
L
I
A
A
A
V
A
Q
G
K
T
V
L
R
D
A
A
E
L
R
V
K
E
T
D
R
I
A
A
M
V
D
G
L
Q
K
L
G
I
A
A
E
S
L
P
D
G
V
I
I
Q
G
G
------
T
-----------
L
---
E
G
G
E
V
N
S
Y
D
D
H
R
I
A
M
A
F
A
V
A
G
T
-
L
-
A
K
G
P
V
R
I
R
N
C
D
N
V
K
T
S
F
P
N
F
V
E
L
A
N
E
V
G
M
N
8
PsiBlast_PDB
65.35
43%
-12
- C7 -
-
3ROI
-
AROA_COXBU
A:
[14-423]
----------
L
S
G
E
I
C
V
P
G
D
K
S
I
S
H
R
A
V
L
L
A
A
I
A
E
G
Q
T
Q
V
D
G
F
L
M
G
A
D
N
L
A
M
V
S
A
L
Q
Q
M
G
A
S
I
Q
V
I
E
-
D
E
-
N
I
L
V
V
E
G
V
G
M
T
G
L
Q
A
P
P
E
A
L
D
C
G
N
S
G
T
A
I
R
L
L
S
G
L
L
A
G
Q
P
F
N
T
V
L
T
G
D
S
S
L
Q
R
R
P
M
K
R
I
I
D
P
L
T
L
M
G
A
K
I
D
--
S
T
G
N
V
P
P
L
K
I
Y
G
N
P
R
L
T
G
I
H
Y
Q
L
--
P
M
A
S
A
Q
V
K
S
C
L
L
L
A
G
L
Y
A
R
G
K
T
C
I
T
E
P
A
P
S
R
D
H
T
E
R
L
L
K
H
F
H
Y
T
L
Q
-------------
S
I
C
V
S
G
G
G
K
L
K
A
N
D
I
S
I
P
G
D
I
S
S
A
A
F
F
I
V
A
A
T
I
T
P
G
S
A
I
R
L
C
R
V
G
V
N
P
T
R
L
G
V
I
N
L
L
K
M
M
G
A
D
I
E
V
T
H
Y
T
E
-
K
--
N
-
E
-------
P
T
A
D
I
T
V
R
H
-
A
R
L
K
G
I
D
I
P
P
D
Q
V
P
L
T
I
D
E
F
P
V
L
L
I
A
A
A
V
A
Q
G
K
T
V
L
R
D
A
A
E
L
R
V
K
E
T
D
R
I
A
A
M
V
D
G
L
Q
K
L
G
I
A
A
E
S
L
P
D
G
V
I
I
Q
G
G
------
T
-----------
L
---
E
G
G
E
V
N
S
Y
D
D
H
R
I
A
M
A
F
A
V
A
G
T
L
--
A
K
G
P
V
R
I
R
N
C
D
N
V
K
T
S
F
P
N
F
V
E
--------
58
HHSearch
63.60
46%
1
- C7 -
-
5BUF
-
?
A:
[23-453]
-------
N
K
A
F
K
G
K
F
T
V
P
G
D
K
S
V
S
H
R
S
I
M
F
G
A
I
A
E
G
T
T
H
V
T
G
F
L
E
G
E
D
A
L
A
T
L
Q
A
F
R
D
M
G
V
S
I
E
--
G
P
K
N
-
G
E
V
T
I
H
G
V
G
M
H
G
L
K
A
P
A
S
A
L
Y
M
G
N
S
G
T
S
M
R
L
L
S
G
M
L
S
A
Q
K
F
D
S
V
M
T
G
D
A
S
L
S
K
R
P
M
E
R
I
A
K
P
L
R
L
M
G
A
Q
I
Q
T
T
G
E
K
G
T
P
P
V
S
I
T
G
G
Q
Q
L
K
G
I
Q
Y
D
L
--
P
M
A
S
A
Q
V
K
S
G
I
L
L
A
G
L
W
A
E
G
E
T
S
V
T
E
P
E
P
T
R
D
H
T
E
R
M
L
R
A
F
G
Y
D
V
K
T
----
E
G
-----
N
K
I
S
L
V
G
G
G
K
L
V
G
T
N
I
Q
V
P
S
D
I
S
S
A
A
F
F
M
V
G
A
A
I
T
E
G
A
D
V
V
L
E
A
V
G
I
N
P
T
R
T
G
V
I
E
I
L
K
Q
M
G
A
D
L
T
V
E
N
E
R
I
A
G
--
G
E
P
--
I
----
A
D
--
I
H
I
K
G
S
R
T
L
K
G
I
H
M
P
E
D
Q
V
P
L
A
I
D
E
F
P
A
L
F
I
A
A
A
C
A
E
G
Q
T
V
L
T
G
A
A
E
L
R
V
K
E
S
D
R
I
Q
V
M
A
D
G
L
K
I
M
G
I
D
C
T
P
T
E
D
G
I
I
I
E
G
K
------
G
---
K
SGDWSPI
F
---
A
G
G
E
I
E
S
H
H
D
H
R
I
A
M
S
F
S
M
A
G
L
-
R
-
T
S
G
P
I
T
I
H
G
T
E
T
V
A
T
S
F
P
T
F
T
E
L
A
N
R
A
G
L
T
11
PsiBlast_PDB
63.53
43%
-5
- C7 -
-
4ZND
2
AROA_COXBU
A:
[14-423]
----------
L
S
G
E
I
C
V
P
G
D
K
S
I
S
H
R
A
V
L
L
A
A
I
A
E
G
Q
T
Q
V
D
G
F
L
M
G
A
D
N
L
A
M
V
S
A
L
Q
Q
M
G
A
S
I
Q
VI
E
-
D
E
-
N
I
L
V
V
E
G
V
G
M
T
G
L
Q
A
P
P
E
A
L
D
C
G
N
S
G
T
A
I
R
L
L
S
G
L
L
A
G
Q
P
F
N
T
V
L
T
G
D
S
S
L
Q
R
R
P
M
K
R
I
I
D
P
L
T
L
M
G
A
K
I
D
--
S
T
G
N
V
P
P
L
K
I
Y
G
N
P
R
L
T
G
I
H
Y
Q
L
--
P
M
A
S
A
Q
V
K
S
C
L
L
L
A
G
L
Y
A
R
G
K
T
C
I
T
E
P
A
P
S
R
D
H
T
E
R
L
L
K
H
F
H
Y
T
L
Q
K
----
D
K
-----
Q
S
I
C
V
S
G
G
G
K
L
K
A
N
D
I
S
I
P
G
D
I
S
S
A
A
F
F
I
V
A
A
T
I
T
P
G
S
A
I
R
L
C
R
V
G
V
N
P
T
R
L
G
V
I
N
L
L
K
M
M
G
A
D
I
E
V
T
H
Y
T
E
-
K
--
N
-
E
--
E
----
P
T
A
D
I
T
V
R
H
-
A
R
L
K
G
I
D
I
P
P
D
Q
V
P
L
T
I
D
E
F
P
V
L
L
I
A
A
A
V
A
Q
G
K
T
V
L
R
D
A
A
E
L
R
V
K
E
T
D
R
I
A
A
M
V
D
G
L
Q
K
L
G
I
A
A
E
S
L
P
D
G
V
I
I
Q
G
G
------
T
-----------
L
---
E
G
G
E
V
N
S
Y
D
D
H
R
I
A
M
A
F
A
V
A
G
T
L
--
A
K
G
P
V
R
I
R
N
C
D
N
V
K
T
S
F
P
N
F
V
E
--------
12
PsiBlast_PDB
63.26
42%
-10
- C7 -
-
3TR1
-
AROA_COXBU
A:
[14-423]
----------
L
S
G
E
I
C
V
P
G
D
K
S
I
S
H
R
A
V
L
L
A
A
I
A
E
G
Q
T
Q
V
D
G
F
L
M
G
A
D
N
L
A
M
V
S
A
L
Q
Q
M
G
A
S
I
Q
V
I
E
-
D
E
-
N
I
L
V
V
E
G
V
G
M
T
G
L
Q
A
P
P
E
A
L
D
C
G
N
S
G
T
A
I
R
L
L
S
G
L
L
A
G
Q
P
F
N
T
V
L
T
G
D
S
S
L
Q
R
R
P
M
K
R
I
I
D
P
L
T
L
M
G
A
K
I
D
--
S
T
G
N
V
P
P
L
K
I
Y
G
N
P
R
L
T
G
I
H
Y
Q
L
--
P
M
A
S
A
Q
V
K
S
C
L
L
L
A
G
L
Y
A
R
G
K
T
C
I
T
E
P
A
P
S
R
D
H
T
E
R
L
L
K
H
F
H
Y
T
L
Q
K
-----
K
-----
Q
S
I
C
V
S
G
G
G
K
L
K
A
N
D
I
S
I
P
G
D
I
S
S
A
A
F
F
I
V
A
A
T
I
T
P
G
S
A
I
R
L
C
R
V
G
V
N
P
T
R
L
G
V
I
N
L
L
K
M
M
G
A
D
I
E
V
T
H
Y
T
E
-
K
--
N
-
E
--
E
----
P
T
A
D
I
T
V
R
H
-
A
R
L
K
G
I
D
I
P
P
D
Q
V
P
L
T
I
D
E
F
P
V
L
L
I
A
A
A
V
A
Q
G
K
T
V
L
R
D
A
A
E
L
R
V
K
E
T
D
R
I
A
A
M
V
D
G
L
Q
K
L
G
I
A
A
E
S
L
P
D
G
V
I
I
Q
G
G
------
T
-----------
L
---
E
G
G
E
V
N
S
Y
D
D
H
R
I
A
M
A
F
A
V
A
G
T
L
--
A
K
G
P
V
R
I
R
N
C
D
N
V
K
T
S
F
P
N
F
V
E
--------
36
PsiBlast_CBE
63.20
43%
-5
- C7 -
-
3SLH
16
AROA_COXBU
D:
[14-423]
----------
L
S
G
E
I
C
V
P
G
D
K
S
I
S
H
R
A
V
L
L
A
A
I
A
E
G
Q
T
Q
V
D
G
F
L
M
G
A
D
N
L
A
M
V
S
A
L
Q
Q
M
G
A
S
I
Q
VI
E
-
D
E
-
N
I
L
V
V
E
G
V
G
M
T
G
L
Q
A
P
P
E
A
L
D
C
G
N
S
G
T
A
I
R
L
L
S
G
L
L
A
G
Q
P
F
N
T
V
L
T
G
D
S
S
L
Q
R
R
P
M
K
R
I
I
D
P
L
T
L
M
G
A
K
I
D
--
S
T
G
N
V
P
P
L
K
I
Y
G
N
P
R
L
T
G
I
H
Y
Q
L
--
P
M
A
S
A
Q
V
K
S
C
L
L
L
A
G
L
Y
A
R
G
K
T
C
I
T
E
P
A
P
S
R
D
H
T
E
R
L
L
K
H
F
H
Y
T
L
Q
K
----
D
K
-----
Q
S
I
C
V
S
G
G
G
K
L
K
A
N
D
I
S
I
P
G
D
I
S
S
A
A
F
F
I
V
A
A
T
I
T
P
G
S
A
I
R
L
C
R
V
G
V
N
P
T
R
L
G
V
I
N
L
L
K
M
M
G
A
D
I
E
V
T
H
Y
T
E
-
K
--
N
-
E
--
E
----
P
T
AD
I
T
V
R
H
-
A
R
L
K
G
I
D
I
P
P
D
Q
V
P
L
T
I
D
E
F
P
V
L
L
I
A
A
A
V
A
Q
G
K
T
V
L
R
D
A
A
E
L
R
V
K
E
T
D
R
I
A
A
M
V
D
G
L
Q
K
L
G
I
A
A
E
S
L
P
D
G
V
I
I
Q
G
G
------
T
-----------
L
---
E
G
G
E
V
N
S
Y
D
D
H
R
I
A
M
A
F
A
V
A
G
T
L
--
A
K
G
P
V
R
I
R
N
C
D
N
V
K
T
S
F
P
N
F
V
E
--------
38
PsiBlast_CBE
63.16
43%
-6
- C7 -
-
3SLH
4
AROA_COXBU
B:
[14-423]
----------
L
S
G
E
I
C
V
P
G
D
K
S
I
S
H
R
A
V
L
L
A
A
I
A
E
G
Q
T
Q
V
D
G
F
L
M
G
A
D
N
L
A
M
V
S
A
L
Q
Q
M
G
A
S
I
Q
V
I
E
-
D
E
-
N
I
L
V
V
E
G
V
G
M
T
G
L
Q
A
P
P
E
A
L
D
C
G
N
S
G
T
A
I
R
L
L
S
G
L
L
A
G
Q
P
F
N
T
V
L
T
G
D
S
S
L
Q
R
R
P
M
K
R
I
I
D
P
L
T
L
M
G
A
K
I
D
--
S
T
G
N
V
P
P
L
K
I
Y
G
N
P
R
L
T
G
I
H
Y
Q
L
--
P
M
A
S
A
Q
V
K
S
C
L
L
L
A
G
L
Y
A
R
G
K
T
C
I
T
E
P
A
P
S
R
D
H
T
E
R
L
L
K
H
F
H
Y
T
L
Q
K
----
D
K
-----
Q
S
I
C
V
S
G
G
G
K
L
K
A
N
D
I
S
I
P
G
D
I
S
S
A
A
F
F
I
V
A
A
T
I
T
P
G
S
A
I
R
L
C
R
V
G
V
N
P
T
R
L
G
V
I
N
L
L
K
M
M
G
A
D
I
E
V
T
H
Y
T
E
-
K
--
N
-
E
--
E
----
P
T
A
D
I
T
V
R
H
-
A
R
L
K
G
I
D
I
P
P
D
Q
V
P
L
T
I
D
E
F
P
V
L
L
I
A
A
A
V
A
Q
G
K
T
V
L
R
D
A
A
E
L
R
V
K
E
T
D
R
I
A
A
M
V
D
G
L
Q
K
L
G
I
A
A
E
S
L
P
D
G
V
I
I
Q
G
G
------
T
-----------
L
---
E
G
G
E
V
N
S
Y
D
D
H
R
I
A
M
A
F
A
V
A
G
T
L
--
A
K
G
P
V
R
I
R
N
C
D
N
V
K
T
S
F
P
N
F
V
E
--------
37
PsiBlast_CBE
63.11
43%
-4
- C7 -
-
3SLH
1
AROA_COXBU
C:
[14-423]
----------
L
S
G
E
I
C
V
P
G
D
K
S
I
S
H
R
A
V
L
L
A
A
I
A
E
G
Q
T
Q
V
D
G
F
L
M
G
A
D
N
L
A
M
V
S
A
L
Q
Q
M
G
A
S
I
Q
VI
E
-
D
E
-
N
I
L
V
V
E
G
V
G
M
T
G
L
Q
A
P
P
E
A
L
D
C
G
N
S
G
T
A
I
R
L
L
S
G
L
L
A
G
Q
P
F
N
T
V
L
T
G
D
S
S
L
Q
R
R
P
M
K
R
I
I
D
P
L
T
L
M
G
A
K
I
D
--
S
T
G
N
V
P
P
L
K
I
Y
G
N
P
R
L
T
G
I
H
Y
Q
L
--
P
M
A
S
A
Q
V
K
S
C
L
L
L
A
G
L
Y
A
R
G
K
T
C
I
T
E
P
A
P
S
R
D
H
T
E
R
L
L
K
H
F
H
Y
T
L
Q
K
----
D
K
-----
Q
S
I
C
V
S
G
G
G
K
L
K
A
N
D
I
S
I
P
G
D
I
S
S
A
A
F
F
I
V
A
A
T
I
T
P
G
S
A
I
R
L
C
R
V
G
V
N
P
T
R
L
G
V
I
N
L
L
K
M
M
G
A
D
I
E
V
T
H
Y
T
E
-
K
--
N
-
E
--
E
----
P
T
AD
I
T
V
R
H
-
A
R
L
K
G
I
D
I
P
P
D
Q
V
P
L
T
I
D
E
F
P
V
L
L
I
A
A
A
V
A
Q
G
K
T
V
L
R
D
A
A
E
L
R
V
K
E
T
D
R
I
A
A
M
V
D
G
L
Q
K
L
G
I
A
A
E
S
L
P
D
G
V
I
I
Q
G
G
------
T
-----------
L
---
E
G
G
E
V
N
S
Y
D
D
H
R
I
A
M
A
F
A
V
A
G
T
L
--
A
K
G
P
V
R
I
R
N
C
D
N
V
K
T
S
F
P
N
F
V
E
--------
14
PsiBlast_PDB
61.90
43%
-24
- C7 -
-
2PQD
1
AROA_AGRSC
A:
[13-438]
----------
L
S
G
T
V
R
I
P
G
D
K
S
I
S
H
R
S
F
M
F
G
G
L
A
S
G
E
T
R
I
T
G
L
L
E
G
E
D
V
I
N
T
G
K
A
M
Q
A
M
G
A
R
I
R
--
K
-
E
G
-
D
T
W
I
I
D
G
V
G
N
G
G
L
L
A
P
E
A
P
L
D
F
G
N
A
G
T
G
C
R
L
T
M
G
L
V
G
V
Y
D
F
D
S
T
F
I
G
D
A
S
L
T
K
R
P
M
G
R
V
L
N
P
L
R
E
M
G
V
Q
V
K
S
E
-
D
G
D
R
L
P
V
T
L
R
G
P
K
T
P
T
P
I
T
Y
R
V
--
P
M
A
S
A
Q
V
K
S
A
V
L
L
A
G
L
N
T
P
G
I
T
T
V
I
E
P
I
M
T
R
D
H
T
E
K
M
L
Q
G
F
G
A
N
L
T
V
E
T
D
A
D
G
V
----
R
T
I
R
L
E
G
R
G
K
L
T
G
Q
V
I
D
V
P
G
D
P
S
S
T
A
F
P
L
V
A
A
L
L
V
P
G
S
D
V
T
I
L
N
V
L
M
N
P
T
R
T
G
L
I
L
T
L
Q
E
M
G
A
D
I
E
V
--
I
N
P
-
R
--
L
-
A
--
G
G
E
D
V
A
D
--
L
R
V
R
S
-
S
T
L
K
G
V
T
V
P
E
D
R
A
P
S
M
I
D
E
Y
P
I
L
A
V
A
A
A
F
A
E
G
A
T
V
M
N
G
L
E
E
L
R
V
K
E
S
D
R
L
S
A
V
A
N
G
L
K
L
N
G
V
D
C
D
E
G
E
T
S
L
V
V
R
G
R
PDGKGL
G
---
N
-------
A
---
S
G
A
A
V
A
T
H
L
D
H
R
I
A
M
S
F
L
V
M
G
-
L
V
-
S
E
N
P
V
T
V
D
D
A
T
M
I
A
T
S
F
P
E
F
M
D
L
M
A
G
L
---
19
PsiBlast_PDB
61.37
42%
-24
- C7 -
-
2GGA
2
AROA_AGRSC
A:
[18-443]
----------
L
S
G
T
V
R
I
P
G
D
K
S
I
S
H
R
S
F
M
F
G
G
L
A
S
G
E
T
R
I
T
G
L
L
E
G
E
D
V
I
N
T
G
K
A
M
Q
A
M
G
A
R
I
R
--
K
-
E
G
-
D
T
W
I
I
D
G
V
G
N
G
G
L
L
A
P
E
A
P
L
D
F
G
N
A
A
T
G
C
R
L
T
M
G
L
V
G
V
Y
D
F
D
S
T
F
I
G
D
A
S
L
T
K
R
P
M
G
R
V
L
N
P
L
R
E
M
G
V
Q
V
K
S
E
-
D
G
D
R
L
P
V
T
L
R
G
P
K
T
P
T
P
I
T
Y
R
V
--
P
M
A
S
A
Q
V
K
S
A
V
L
L
A
G
L
N
T
P
G
I
T
T
V
I
E
P
I
M
T
R
D
H
T
E
K
M
L
Q
G
F
G
A
N
L
T
V
E
T
D
A
D
G
V
----
R
T
I
R
L
E
G
R
G
K
L
T
G
Q
V
I
D
V
P
G
D
P
S
S
T
A
F
P
L
V
A
A
L
L
V
P
G
S
D
V
T
I
L
N
V
L
M
N
P
T
R
T
G
L
I
L
T
L
Q
E
M
G
A
D
I
E
V
--
I
N
P
-
R
--
L
-
A
--
G
G
E
D
V
A
D
--
L
R
V
R
S
-
S
T
L
K
G
V
T
V
P
E
D
R
A
P
S
M
I
D
E
Y
P
I
L
A
V
A
A
A
F
A
E
G
A
T
V
M
N
G
L
E
E
L
R
V
K
E
S
D
R
L
S
A
V
A
N
G
L
K
L
N
G
V
D
C
D
E
G
E
T
S
L
V
V
R
G
R
PDGKGL
G
---
N
-------
A
---
S
G
A
A
V
A
T
H
L
D
H
R
I
A
M
S
F
L
V
M
G
-
L
V
-
S
E
N
P
V
T
V
D
D
A
T
M
I
A
T
S
F
P
E
F
M
D
L
M
A
G
L
---
16
PsiBlast_PDB
61.31
42%
-26
- C7 -
-
2PQC
1
AROA_AGRSC
A:
[13-438]
----------
L
S
G
T
V
R
I
P
G
D
K
S
I
S
H
R
S
F
M
F
G
G
L
A
S
G
E
T
R
I
T
G
L
L
E
G
E
D
V
I
N
T
G
K
A
M
Q
A
M
G
A
R
I
R
--
K
-
E
G
-
D
T
W
I
I
D
G
V
G
N
G
G
L
L
A
P
E
A
P
L
D
F
G
N
A
A
T
G
C
R
L
T
M
G
L
V
G
V
Y
D
F
D
S
T
F
I
G
D
A
S
L
T
K
R
P
M
G
R
V
L
N
P
L
R
E
M
G
V
Q
V
K
S
E
-
D
G
D
R
L
P
V
T
L
R
G
P
K
T
P
T
P
I
T
Y
R
V
--
P
M
A
S
A
Q
V
K
S
A
V
L
L
A
G
L
N
T
P
G
I
T
T
V
I
E
P
I
M
T
R
D
H
T
E
K
M
L
Q
G
F
G
A
N
L
T
V
E
T
D
A
D
G
V
----
R
T
I
R
L
E
G
R
G
K
L
T
G
Q
V
I
D
V
P
G
D
P
S
S
T
A
F
P
L
V
A
A
L
L
V
P
G
S
D
V
T
I
L
N
V
L
M
N
P
T
R
T
G
L
I
L
T
L
Q
E
M
G
A
D
I
E
V
--
I
N
P
-
R
--
L
-
A
--
G
G
E
D
V
A
D
--
L
R
V
R
S
-
S
T
L
K
G
V
T
V
P
E
D
R
A
P
S
M
I
D
E
Y
P
I
L
A
V
A
A
A
F
A
E
G
A
T
V
M
N
G
L
E
E
L
R
V
K
E
S
D
R
L
S
A
V
A
N
G
L
K
L
N
G
V
D
C
D
E
G
E
T
S
L
V
V
R
G
R
PDGKGL
G
---
N
-------
A
---
S
G
A
A
V
A
T
H
L
D
H
R
I
A
M
S
F
L
V
M
G
-
L
V
-
S
E
N
P
V
T
V
D
D
A
T
M
I
A
T
S
F
P
E
F
M
D
L
M
A
G
L
---
13
PsiBlast_PDB
61.31
43%
-22
- C7 -
-
2GGD
2
AROA_AGRSC
A:
[18-443]
----------
L
S
G
T
V
R
I
P
G
D
K
S
I
S
H
R
S
F
M
F
G
G
L
A
S
G
E
T
R
I
T
G
L
L
E
G
E
D
V
I
N
T
G
K
A
M
Q
A
M
G
A
R
I
R
--
K
-
E
G
-
D
T
W
I
I
D
G
V
G
N
G
G
L
L
A
P
E
A
P
L
D
F
G
N
A
G
T
G
C
R
L
T
M
G
L
V
G
V
Y
D
F
D
S
T
F
I
G
D
A
S
L
T
K
R
P
M
G
R
V
L
N
P
L
R
E
M
G
V
Q
V
K
S
E
-
D
G
D
R
L
P
V
T
L
R
G
P
K
T
P
T
P
I
T
Y
R
V
--
P
M
A
S
A
Q
V
K
S
A
V
L
L
A
G
L
N
T
P
G
I
T
T
V
I
E
P
I
M
T
R
D
H
T
E
K
M
L
Q
G
F
G
A
N
L
T
V
E
T
D
A
D
G
V
----
R
T
I
R
L
E
G
R
G
K
L
T
G
Q
V
I
D
V
P
G
D
P
S
S
T
A
F
P
L
V
A
A
L
L
V
P
G
S
D
V
T
I
L
N
V
L
M
N
P
T
R
T
G
L
I
L
T
L
Q
E
M
G
A
D
I
E
V
--
I
N
P
-
R
--
L
-
A
--
G
G
E
D
V
A
D
--
L
R
V
R
S
-
S
T
L
K
G
V
T
V
P
E
D
R
A
P
S
M
I
D
E
Y
P
I
L
A
V
A
A
A
F
A
E
G
A
T
V
M
N
G
L
E
E
L
R
V
K
E
S
D
R
L
S
A
V
A
N
G
L
K
L
N
G
V
D
C
D
E
G
E
T
S
L
V
V
R
G
R
PDGKGL
G
---
N
-------
A
---
S
G
A
A
V
A
T
H
L
D
H
R
I
A
M
S
F
L
V
M
G
-
L
V
-
S
E
N
P
V
T
V
D
D
A
T
M
I
A
T
S
F
P
E
F
M
D
L
M
A
G
L
---
15
PsiBlast_PDB
60.99
42%
-23
- C7 -
-
2PQB
1
AROA_AGRSC
A:
[13-438]
----------
L
S
G
T
V
R
I
P
G
D
K
S
I
S
H
R
S
F
M
F
G
G
L
A
S
G
E
T
R
I
T
G
L
L
E
G
E
D
V
I
N
T
G
K
A
M
Q
A
M
G
A
R
I
R
--
K
-
E
G
-
D
T
W
I
I
D
G
V
G
N
G
G
L
L
A
P
E
A
P
L
D
F
G
N
A
A
T
G
C
R
L
T
M
G
L
V
G
V
Y
D
F
D
S
T
F
I
G
D
A
S
L
T
K
R
P
M
G
R
V
L
N
P
L
R
E
M
G
V
Q
V
K
S
E
-
D
G
D
R
L
P
V
T
L
R
G
P
K
T
P
T
P
I
T
Y
R
V
--
P
M
A
S
A
Q
V
K
S
A
V
L
L
A
G
L
N
T
P
G
I
T
T
V
I
E
P
I
M
T
R
D
H
T
E
K
M
L
Q
G
F
G
A
N
L
T
V
E
T
D
A
D
G
V
----
R
T
I
R
L
E
G
R
G
K
L
T
G
Q
V
I
D
V
P
G
D
P
S
S
T
A
F
P
L
V
A
A
L
L
V
P
G
S
D
V
T
I
L
N
V
L
M
N
P
T
R
T
G
L
I
L
T
L
Q
E
M
G
A
D
I
E
V
--
I
N
P
-
R
--
L
-
A
--
G
G
E
D
V
A
D
--
L
R
V
R
S
-
S
T
L
K
G
V
T
V
P
E
D
R
A
P
S
M
I
D
E
Y
P
I
L
A
V
A
A
A
F
A
E
G
A
T
V
M
N
G
L
E
E
L
R
V
K
E
S
D
R
L
S
A
V
A
N
G
L
K
L
N
G
V
D
C
D
E
G
E
T
S
L
V
V
R
G
R
PDGKGL
G
---
N
-------
A
---
S
G
A
A
V
A
T
H
L
D
H
R
I
A
M
S
F
L
V
M
G
-
L
V
-
S
E
N
P
V
T
V
D
D
A
T
M
I
A
T
S
F
P
E
F
M
D
L
M
A
G
L
---
18
PsiBlast_PDB
60.79
42%
-23
- C7 -
-
2GG6
1
AROA_AGRSC
A:
[18-443]
----------
L
S
G
T
V
R
I
P
G
D
K
S
I
S
H
R
S
F
M
F
G
G
L
A
S
G
E
T
R
I
T
G
L
L
E
G
E
D
V
I
N
T
G
K
A
M
Q
A
M
G
A
R
I
R
--
K
-
E
G
-
D
T
W
I
I
D
G
V
G
N
G
G
L
L
A
P
E
A
P
L
D
F
G
N
A
A
T
G
C
R
L
T
M
G
L
V
G
V
Y
D
F
D
S
T
F
I
G
D
A
S
L
T
K
R
P
M
G
R
V
L
N
P
L
R
E
M
G
V
Q
V
K
S
E
-
D
G
D
R
L
P
V
T
L
R
G
P
K
T
P
T
P
I
T
Y
R
V
--
P
M
A
S
A
Q
V
K
S
A
V
L
L
A
G
L
N
T
P
G
I
T
T
V
I
E
P
I
M
T
R
D
H
T
E
K
M
L
Q
G
F
G
A
N
L
T
V
E
T
D
A
D
G
V
----
R
T
I
R
L
E
G
R
G
K
L
T
G
Q
V
I
D
V
P
G
D
P
S
S
T
A
F
P
L
V
A
A
L
L
V
P
G
S
D
V
T
I
L
N
V
L
M
N
P
T
R
T
G
L
I
L
T
L
Q
E
M
G
A
D
I
E
V
--
I
N
P
-
R
--
L
-
A
--
G
G
E
D
V
A
D
--
L
R
V
R
S
-
S
T
L
K
G
V
T
V
P
E
D
R
A
P
S
M
I
D
E
Y
P
I
L
A
V
A
A
A
F
A
E
G
A
T
V
M
N
G
L
E
E
L
R
V
K
E
S
D
R
L
S
A
V
A
N
G
L
K
L
N
G
V
D
C
D
E
G
E
T
S
L
V
V
R
G
R
PDGKGL
G
---
N
-------
A
---
S
G
A
A
V
A
T
H
L
D
H
R
I
A
M
S
F
L
V
M
G
-
L
V
-
S
E
N
P
V
T
V
D
D
A
T
M
I
A
T
S
F
P
E
F
M
D
L
M
A
G
L
---
51
HHSearch
58.06
42%
11
- C7 -
-
2PQB
1
AROA_AGRSC
A:
[4-441]
-
P
A
T
A
R
K
S
S
G
L
S
G
T
V
R
I
P
G
D
K
S
I
S
H
R
S
F
M
F
G
G
L
A
S
G
E
T
R
I
T
G
L
L
E
G
E
D
V
I
N
T
G
K
A
M
Q
A
M
G
A
R
I
R
--
K
-
E
G
-
D
T
W
I
I
D
G
V
G
N
G
G
L
L
A
P
E
A
P
L
D
F
G
N
A
A
T
G
C
R
L
T
M
G
L
V
G
V
Y
D
F
D
S
T
F
I
G
D
A
S
L
T
K
R
P
M
G
R
V
L
N
P
L
R
E
M
G
V
Q
V
K
S
-
E
D
G
D
R
L
P
V
T
L
R
G
P
--
K
T
P
T
P
I
T
Y
R
V
P
M
A
S
A
Q
V
K
S
A
V
L
L
A
G
L
N
T
P
G
I
T
T
V
I
E
P
I
M
T
R
D
H
T
E
K
M
L
Q
G
F
G
A
N
L
T
V
----
E
T
D
ADG
V
R
T
I
R
L
E
G
R
G
K
L
T
G
Q
V
I
D
V
P
G
D
P
S
S
T
A
F
P
L
V
A
A
L
L
V
P
G
S
D
V
T
I
L
N
V
L
M
N
P
T
R
T
G
L
I
L
T
L
Q
E
M
G
A
D
I
E
V
I
N
P
R
L
-
A
--
G
-
G
E
D
V
----
A
D
--
L
R
V
R
S
-
S
T
L
K
G
V
T
V
P
E
D
R
A
P
S
M
I
D
E
Y
P
I
L
A
V
A
A
A
F
A
E
G
A
T
V
M
N
G
L
E
E
L
R
V
K
E
S
D
R
L
S
A
V
A
N
G
L
K
L
N
G
V
D
C
D
E
G
E
T
S
L
V
V
R
G
R
------
P
DGK
G
-------
L
GNA
S
G
A
A
V
A
T
H
L
D
H
R
I
A
M
S
F
L
V
M
G
L
-
V
-
S
E
N
P
V
T
V
D
D
A
T
M
I
A
T
S
F
P
E
F
M
D
L
M
A
G
L
G
A
K
52
HHSearch
57.79
42%
12
- C7 -
-
2PQC
1
AROA_AGRSC
A:
[4-441]
-
P
A
T
A
R
K
S
S
G
L
S
G
T
V
R
I
P
G
D
K
S
I
S
H
R
S
F
M
F
G
G
L
A
S
G
E
T
R
I
T
G
L
L
E
G
E
D
V
I
N
T
G
K
A
M
Q
A
M
G
A
R
I
R
--
K
-
E
G
-
D
T
W
I
I
D
G
V
G
N
G
G
L
L
A
P
E
A
P
L
D
F
G
N
A
A
T
G
C
R
L
T
M
G
L
V
G
V
Y
D
F
D
S
T
F
I
G
D
A
S
L
T
K
R
P
M
G
R
V
L
N
P
L
R
E
M
G
V
Q
V
K
S
-
E
D
G
D
R
L
P
V
T
L
R
G
P
--
K
T
P
T
P
I
T
Y
R
V
P
M
A
S
A
Q
V
K
S
A
V
L
L
A
G
L
N
T
P
G
I
T
T
V
I
E
P
I
M
T
R
D
H
T
E
K
M
L
Q
G
F
G
A
N
L
T
V
----
E
T
D
ADG
V
R
T
I
R
L
E
G
R
G
K
L
T
G
Q
V
I
D
V
P
G
D
P
S
S
T
A
F
P
L
V
A
A
L
L
V
P
G
S
D
V
T
I
L
N
V
L
M
N
P
T
R
T
G
L
I
L
T
L
Q
E
M
G
A
D
I
E
V
I
N
P
R
L
-
A
--
G
-
G
E
D
V
----
A
D
--
L
R
V
R
S
-
S
T
L
K
G
V
T
V
P
E
D
R
A
P
S
M
I
D
E
Y
P
I
L
A
V
A
A
A
F
A
E
G
A
T
V
M
N
G
L
E
E
L
R
V
K
E
S
D
R
L
S
A
V
A
N
G
L
K
L
N
G
V
D
C
D
E
G
E
T
S
L
V
V
R
G
R
------
P
DGK
G
-------
L
GNA
S
G
A
A
V
A
T
H
L
D
H
R
I
A
M
S
F
L
V
M
G
L
-
V
-
S
E
N
P
V
T
V
D
D
A
T
M
I
A
T
S
F
P
E
F
M
D
L
M
A
G
L
G
A
K