@TOME V2.3
(Mar 2018)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : spr1233: (2018-01-07 )
MKIRIDIPHHPYDIQIEKGCMAQAGQWLRELWQPQKVVIVTDNHVASLYAEKVKLSLEDAGFQVAVFDFLEGEERKNLTTVQKVYEFLVKQGLTRSDGIVALGGGVVGDLAGFVASTYMRGIHFVQIPTSLTAQVDSSIGGKTGVNTPFAKNMVGTFAQPDGVLIDPLVLETLGKRELIEGMGEVIKYGLIEDPELWALLTGLNGSVESILEHAETLIEHSCQVKRKMVVEDELDNGIRLYLNFGHTIGHAIEATAGYGKVMHGEAVAMGMVQISKIAEEKGLMPAGITQSITEMCQKFGLPVDYENWEVDKLYQALTHDKKARGNTLKLVLVPELGSATIHPVSLEEMKDYLVK
Atome Classification :
(41 SA)
.........10........20..-....-..30...----.....40........50..--.--...-..60.------...------....70........80........90.--...-....-100.......110.......120.......130.......140.......150.......160.......170.......180.......190-----......----..----200.-......--.---------------210-------......-.---.---220-------------.........230.......240.......250......-.260.......270.......280.......290.......300.-..-.-.-----------.-----------.310-----------..-.....320..-----.....330...-....340--..------.-------.....350...
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
M
K
I
R
IDIPHH
P
Y
D
I
Q
IEK
G
C
M
A
Q
-
A
G
Q
W
-
L
R
E
LWQP----
Q
K
V
V
I
V
TD
N
H
V
A
S
L
Y
A
E
K
V
--
K
--
L
S
L-EDAG
F
------
Q
V
A
------
V
F
D
FLEGEERKN
L
T
T
V
Q
K
V
Y
E
F
L
V
KQG--LTR-SD
G
I
-
V
A
LGG
G
V
V
G
D
L
A
G
F
V
A
S
T
Y
MR
G
I
H
F
V
QIP
T
S
L
T
A
Q
V
D
SSIGGKTGVNTP
F
A
K
N
M
V
GTFAQPD
G
V
L
I
D
P
L
V
L
E
TL
G
K
R
E
L
I
E
G
M
G
E
V
I
K
YGLI------ED
P
E
L
W
----
A
L
----
L
-TG-LN
G
S
V
E
--
S
---------------
I
L
--------
E
H
A
E
T
L
-
I
---
E
---
H
---------------
S
C
Q
V
K
R
K
M
V
V
E
DELDN
G
I
R
L
Y
L
NFGHTIG
H
A
IEATAGY-GKVMH
G
E
A
V
A
M
G
M
V
Q
I
S
K
I
A
E
EKGLMPAG
I
T
Q
S
I
T
E
M
C
Q
KFGLPV-DY-E-N-----------W-----------
E
V
D
K
-----------
L
Y
-
Q
A
L
THDKKAR-----G
N
T
L
K
L
V
L
VPE-LGSATI---HP------V-------
S
L
E
E
M
K
D
Y
LVK
49
HHSearch
96.05
40%
-94
- C3 -
-
3OKF
1
AROB_VIBCH
B:
[34-385]
---
T
V
N
L
G
E
R
S
Y
P
I
S
I
G
A
G
L
F
A
N
--
P
A
L
-
L
S
L
-
S
A
K
----
Q
K
V
V
I
V
T
N
H
T
V
A
P
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Y
A
P
A
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--
I
--
S
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-
D
H
I
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C
------
Q
H
A
------
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H
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--
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-
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-
I
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A
A
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N
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M
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G
A
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Y
Q
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K
A
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V
I
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T
T
L
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A
A
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M
A
E
V
I
K
Y
G
I
I
------
Y
D
S
A
F
F
----
D
W
----
L
-
E
A
-
Q
M
E
A
L
Y
A
-
L
---------------
D
E
--------
Q
A
L
T
Y
A
-
I
---
A
---
R
---------------
C
C
Q
I
K
A
E
V
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A
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L
N
L
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A
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M
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N
-
W
L
H
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E
A
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A
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A
A
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A
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Q
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I
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A
I
L
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K
A
H
L
P
V
-
R
T
-
P
-
E
N----------
M
-----------
T
F
A
D
-----------
F
M
-
Q
H
M
M
R
---------------
L
V
L
P
T
S
-
I
G
T
S
A
V
---
V
K
------
G
V------
P
E
A
V
I
A
Q
A
I
E
-
1
PsiBlast_PDB
94.37
42%
-101
- C3 -
-
3OKF
1
AROB_VIBCH
A:
[32-371]
-
R
I
T
V
N
L
G
E
R
S
Y
P
I
S
I
G
A
G
L
F
A
N
-
P
A
---
L
L
S
L
S
A
K
----
Q
K
V
V
I
V
T
N
H
T
V
A
P
L
Y
A
P
A
I
--
I
--
S
L
L
-
D
H
I
G
C
------
Q
H
A
------
L
L
E
L
P
D
G
E
Q
Y
K
T
L
E
T
F
N
T
V
M
S
F
L
L
E
H
N
--
Y
S
R
-
D
V
V
V
-
I
A
L
G
G
G
V
I
G
D
L
V
G
F
A
A
A
C
Y
Q
R
G
V
D
F
I
Q
I
P
T
T
L
L
S
Q
V
D
S
S
V
G
G
K
T
A
V
N
H
P
L
G
K
N
M
I
G
A
F
Y
Q
P
K
A
V
V
I
D
T
D
C
L
T
T
L
P
A
R
E
F
A
A
G
M
A
E
V
I
K
Y
G
I
I
------
Y
D
S
A
F
F
----
D
W
----
L
-
E
A
-
Q
M
E
A
L
Y
--
A
---------------
L
D
--------
E
Q
A
L
T
Y
A
I
---
A
---
R
---------------
C
C
Q
I
K
A
E
V
V
A
Q
D
E
K
--
G
I
R
A
L
L
N
L
G
H
T
F
G
H
A
I
E
A
H
M
G
Y
-
G
N
W
L
H
G
E
A
V
S
A
G
T
V
M
A
A
K
T
A
Q
L
Q
G
L
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A
S
Q
F
E
R
I
L
A
I
L
K
K
A
H
L
P
V
-
R
T
P
E
-
N
-----------
M
-----------
T
F
A
D
-----------
F
M
-
Q
H
M
M
R
D
K
K
V
L
-----
A
G
E
L
R
L
V
L
P
T
S
-
I
G
T
S
A
V
------------------------------
50
HHSearch
93.18
40%
-93
- C3 -
-
3OKF
1
AROB_VIBCH
A:
[34-385]
---
T
V
N
L
G
E
R
S
Y
P
I
S
I
G
A
G
L
F
A
N
--
P
A
L
-
L
S
L
-
S
A
K
----
Q
K
V
V
I
V
T
N
H
T
V
A
P
L
Y
A
P
A
I
--
I
--
S
L
L
-
D
H
I
G
C
------
Q
H
A
------
L
L
E
L
P
D
G
E
Q
Y
K
T
L
E
T
F
N
T
V
M
S
F
L
L
E
H
N
--
Y
S
R
-
D
V
V
V
-
I
A
L
G
G
G
V
I
G
D
L
V
G
F
A
A
A
C
Y
Q
R
G
V
D
F
I
Q
I
P
T
T
L
L
S
Q
V
D
S
S
V
G
G
K
T
A
V
N
H
P
L
G
K
N
M
I
G
A
F
Y
Q
P
K
A
V
V
I
D
T
D
C
L
T
T
L
P
A
R
E
F
A
A
G
M
A
E
V
I
K
Y
G
I
I
------
Y
D
S
A
F
F
----
D
W
----
L
-
E
A
-
Q
M
E
A
L
Y
A
-
L
---------------
D
E
--------
Q
A
L
T
Y
A
-
I
---
A
---
R
---------------
C
C
Q
I
K
A
E
V
V
A
Q
D
E
K
--
G
I
R
A
L
L
N
L
G
H
T
F
G
H
A
I
E
A
H
M
G
Y
G
N
-
W
L
H
G
E
A
V
S
A
G
T
V
M
A
A
K
T
A
Q
L
Q
G
L
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A
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Q
F
E
R
I
L
A
I
L
K
K
A
H
L
P
V
-
R
T
-
P
-
E
N----------
M
-----------
T
F
A
D
-----------
F
M
-
Q
H
M
M
R
D
K
K
V
L
-----
A
G
E
L
R
L
V
L
P
T
S
-
I
G
T
S
A
V
---
V
K
------
G
V------
P
E
A
V
I
A
Q
A
I
E
-
48
HHSearch
87.85
37%
-82
- C3 -
-
5EKS
1
?
A:
[14-363]
----
V
E
L
G
E
R
R
Y
P
I
F
I
G
S
Q
-
L
D
P
-
K
-
Q
L
-
L
E
P
Y
I
H
G
----
Q
Q
V
M
I
V
S
N
V
T
V
A
P
L
Y
L
S
H
Y
--
Q
--
E
A
L
-
E
S
L
G
K
------
T
V
A
------
T
C
I
L
P
D
G
E
K
Y
K
D
I
Q
H
L
N
L
I
F
D
A
L
L
E
A
G
--
F
N
R
-
D
C
T
V
-
L
A
L
G
G
G
V
I
G
D
M
A
G
F
A
S
A
C
F
Q
R
G
V
Y
F
V
Q
V
P
T
T
L
L
S
Q
V
D
S
S
V
G
G
K
T
G
I
N
H
P
L
G
K
N
M
L
G
A
F
Q
Q
P
Q
V
V
L
A
D
M
A
Q
L
N
T
L
P
E
R
E
L
S
A
G
L
A
E
V
I
K
Y
A
L
L
------
G
D
E
D
F
L
----
V
W
----
L
-
E
E
-
N
M
D
G
L
V
A
-
R
---------------
D
A
--------
D
L
L
A
E
A
-
V
---
Y
---
R
---------------
S
C
A
H
K
A
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I
V
A
N
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E
K
E
---
R
A
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G
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A
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E
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G
Y
G
T
-
W
L
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M
A
A
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-----------
I
-----------
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-----------
F
L
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Y
M
A
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V
--------
Q
L
R
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L
L
K
Q
-
L
G
Q
A
V
I
---
T
K
------
D
F------
D
V
E
L
M
K
Q
A
I
L
-
40
HHSearch
81.37
33%
-74
- C3 -
-
3QBE
-
AROB_MYCTU
A:
[19-363]
------
A
V
D
P
P
Y
P
V
V
I
G
T
G
L
L
D
E
-
L
E
D
L
-
L
A
D
---
R
----
H
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A
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V
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Q
P
G
L
A
E
-
T
A
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E
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--
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--
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L
-
A
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K
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V
------
D
A
H
------
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--
I
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K
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A
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L
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M
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A
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L
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D
L
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M
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M
A
E
V
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K
A
G
F
I
------
A
D
P
V
I
L
----
D
L
----
I
-
E
A
-
D
P
Q
A
A
L
DP
A
---------------
G
D
--------
V
L
P
-
E
L
-
I
---
R
---
R
---------------
A
I
T
V
K
A
E
V
V
A
A
----
S
E
L
R
E
I
L
N
Y
G
H
T
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G
H
A
I
E
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R
E
R
Y
-
R
-
W
R
H
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A
A
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A
A
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-
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-
P
-----------
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-----------
A
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-----------
L
L
-
E
I
M
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K
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T
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-----
A
G
V
L
R
F
V
V
L
D
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-
L
A
K
P
G
R
---
M
V
------
G
P------
D
P
G
L
L
V
T
A
Y
A
-
42
HHSearch
80.72
30%
-69
- C3 -
-
1XAG
2
AROB_STAAR
A:
[1-347]
M
K
L
Q
T
T
Y
P
S
N
N
Y
P
I
Y
V
E
H
G
A
I
K
Y
-
I
G
T
Y
-
L
N
Q
---
F
----
D
Q
S
F
L
L
I
D
E
Y
V
N
Q
Y
F
A
N
K
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--
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--
D
I
L
-
S
Y
E
N
--------
V
H
------
K
V
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I
P
A
G
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F
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Q
Y
Q
E
T
L
E
Y
I
L
S
H
H
--
V
T
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-
N
T
A
I
-
I
A
V
G
G
G
A
T
G
D
F
A
G
F
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A
A
T
L
L
R
G
V
H
F
I
Q
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P
T
T
I
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A
H
-
D
S
S
V
G
G
K
V
G
I
N
S
K
Q
G
K
N
L
I
G
A
F
Y
R
P
T
A
V
I
Y
D
L
D
F
L
K
T
L
P
F
K
Q
I
L
S
G
Y
A
E
V
Y
K
H
A
L
L
------
N
G
E
S
A
T
----
Q
D
----
I
-
E
Q
-
H
F
K
D
R
E
I
L
Q
---------------
S
L
--------
N
G
M
D
K
Y
-
I
---
A
---
K
---------------
G
I
E
T
K
L
D
I
V
V
A
D
E
K
E
Q
G
V
R
K
F
L
N
L
G
H
T
F
G
H
A
V
E
Y
Y
--
H
-
K
-
I
P
H
G
H
A
V
M
V
G
I
I
Y
Q
F
I
V
A
N
A
L
F
D
-
S
K
H
D
I
S
H
Y
I
Q
Y
L
I
Q
L
G
Y
P
L
-
D
M
-
I
T
D
-----------
L
-----------
D
F
E
T
-----------
L
Y
-
Q
Y
M
L
S
D
K
K
N
D
-----
K
Q
G
V
Q
M
V
L
M
R
Q
-
F
G
D
I
V
V
---
Q
H
------
V
-------
D
Q
L
T
L
Q
H
A
C
E
-
51
HHSearch
79.22
36%
-45
- C3 -
-
5HVN
1
AROB_FRATT
A:
[15-359]
--------
S
P
S
Y
N
I
I
V
D
S
V
L
--
D
-
F
S
H
I
-
L
E
Y
-
V
T
N
----
K
Q
V
L
V
V
T
N
T
T
V
A
K
L
Y
L
T
K
F
--
L
--
A
A
L
-
V
D
-
D
L
------
D
V
R
------
T
C
I
L
E
D
G
E
Q
Y
K
S
Q
Q
S
L
D
K
I
L
S
T
L
L
E
N
H
--
F
T
R
N
S
T
V
L
-
V
A
L
G
G
G
V
I
G
D
I
T
G
F
A
A
A
I
Y
Q
R
G
I
D
F
I
Q
I
P
T
T
L
L
S
Q
V
D
S
S
V
G
G
K
T
A
I
N
H
Q
L
G
K
N
M
I
G
A
F
Y
Q
P
K
V
V
Y
T
S
I
E
F
Y
K
T
L
P
Q
R
E
Y
I
A
G
M
A
E
V
V
K
Y
A
F
I
------
S
K
-
D
F
Y
----
L
W
----
L
-
D
S
-
N
R
D
K
I
L
A
-
K
---------------
D
S
--------
V
T
L
I
E
M
-
V
---
K
---
R
---------------
S
C
Q
I
K
A
Q
V
V
A
M
D
---
T
G
A
R
A
I
L
N
F
G
H
T
F
G
H
A
I
E
K
C
Q
N
Y
R
G
-
L
K
H
G
E
A
V
G
V
G
M
A
Q
A
I
D
F
S
H
Y
L
G
L
I
S
Q
Q
Q
A
K
D
F
N
D
F
I
V
S
F
G
I
S
I
-
D
F
-
P
-
N
D----------
I
-----------
C
Q
K
E
-----------
F
L
-
E
A
M
L
L
D
---------
N
K
E
L
K
F
I
L
I
E
N
-
I
G
S
L
S
L
---
Q
K
------
Q
-------
S
K
N
E
L
E
Q
F
L
D
-
44
HHSearch
77.90
36%
-27
* C3 *
-
3ZOK
2
DHQS_ACTCH
D:
[17-373]
--
V
D
V
D
L
G
D
R
S
Y
P
I
Y
I
G
S
G
L
L
D
Q
-
P
D
L
L
-
Q
R
H
-
V
H
G
----
K
R
V
L
V
V
T
N
S
T
V
A
P
I
Y
L
D
K
V
--
V
--
G
A
L
-
T
N
E
N
P
NV----
S
V
E
------
S
V
I
L
P
D
G
E
K
Y
K
N
M
D
T
L
M
K
V
F
D
K
A
I
E
S
R
--
L
D
R
-
R
C
T
F
-
V
A
L
G
G
G
V
I
G
D
M
C
G
Y
A
A
A
S
F
L
R
G
V
N
F
I
Q
I
P
T
T
V
M
A
Q
V
D
S
S
V
G
G
K
T
G
I
N
H
R
L
G
K
N
L
I
G
A
F
Y
Q
P
Q
C
V
L
I
D
T
D
T
L
N
T
L
P
D
R
E
L
A
S
G
L
A
E
V
V
K
Y
G
L
I
------
R
D
A
N
F
F
----
E
W
----
Q
-
E
K
-
N
M
P
A
L
M
A-
R
---------------
D
P
--------
S
A
L
A
Y
A
-
I
---
K
---
R
---------------
S
C
E
N
K
A
E
V
V
S
L
D
E
K
E
S
G
L
R
A
T
L
N
L
G
H
T
F
G
H
A
I
E
T
G
F
G
Y
G
Q
-
W
L
H
G
E
A
V
A
A
G
M
V
M
A
V
D
M
S
Y
R
L
G
W
I
D
E
S
I
V
N
R
A
H
N
I
L
Q
Q
A
K
L
P
T
-
A
P
-
P
-
E
T----------
M
-----------
T
V
E
M
-----------
F
K
-
S
V
M
A
V
D
K
K
V
A
-----
D
G
L
L
R
L
I
L
L
K
G
P
L
G
N
C
V
F
---
T
G
------
D
Y------
D
R
K
A
L
D
E
T
L
H
-
38
PsiBlast_CBE
77.72
32%
-89
- C3 -
-
1XAH
1
AROB_STAAR
B:
[1-352]
M
K
L
Q
T
T
Y
P
S
N
N
Y
P
I
Y
V
E
H
G
A
I
K
Y
-
I
G
T
Y
-
L
N
Q
F
D
Q
S
-------
F
L
L
I
D
E
Y
V
N
Q
Y
F
A
N
K
F
--
D
-------
N
----------
V
H
------
K
V
I
I
P
A
G
E
K
T
K
T
F
E
Q
Y
Q
E
T
L
E
Y
I
L
S
H
H
--
V
T
R
-
N
T
A
I
-
I
A
V
G
G
G
A
T
G
D
F
A
G
F
V
A
A
T
L
L
R
G
V
H
F
I
Q
V
P
T
T
I
L
A
H
-
D
S
S
V
G
G
K
V
G
I
N
S
K
Q
G
K
N
L
I
G
A
F
Y
R
P
T
A
V
I
Y
D
L
D
F
L
K
T
L
P
F
K
Q
I
L
S
G
Y
A
E
V
Y
K
H
A
L
L
NGESAT
Q
D
I
E
Q
H
FKDR
E
I
----
L
-
Q
S
-
L
N
G
M
D
K
--
Y
---------------
I
A
--------
K
G
I
E
T
------------------------------
K
L
D
I
V
V
A
D
E
K
E
Q
G
V
R
K
F
L
N
L
G
H
T
F
G
H
A
V
E
Y
---
Y
-
H
K
I
P
H
G
H
A
V
M
V
G
I
I
Y
Q
F
I
V
A
N
A
L
F
D
S
K
H
D
I
S
H
Y
I
Q
Y
L
I
Q
-
L
G
Y
P
L
-
D
-------------------------------
T
-----------
L
Y
-
Q
Y
M
L
-------------
G
V
Q
M
V
L
M
R
Q
-
F
G
D
I
V
V
---
Q
H
------
V
DQLTLQH
A
C
E
Q
L
K
T
Y
---
22
PsiBlast_CBE
77.72
38%
-26
- C3 -
-
3ZOK
2
DHQS_ACTCH
D:
[17-350]
--
V
D
V
D
L
G
D
R
S
Y
P
I
Y
I
G
S
G
L
L
D
Q
-
P
D
L
L
-
Q
R
H
V
-
H
G
----
K
R
V
L
V
V
T
N
S
T
V
A
P
I
Y
L
D
K
V
VG
A
--
L
T
N
-
E
N
P
N
V
------
S
V
E
------
S
V
I
L
P
D
G
E
K
Y
K
N
M
D
T
L
M
K
V
F
D
K
A
I
E
S
R
--
L
D
R
-
R
C
T
F
-
V
A
L
G
G
G
V
I
G
D
M
C
G
Y
A
A
A
S
F
L
R
G
V
N
F
I
Q
I
P
T
T
V
M
A
Q
V
D
S
S
V
G
G
K
T
G
I
N
H
R
L
G
K
N
L
I
G
A
F
Y
Q
P
Q
C
V
L
I
D
T
D
T
L
N
T
L
P
D
R
E
L
A
S
G
L
A
E
V
V
K
Y
G
L
I
------
R
D
A
N
F
F
----
E
W
QEKN
M
-
P
A
-
L
M
A
R
D
P
--
S
---------------
A
L
--------
A
Y
A
----
I
---
K
---
R
---------------
S
C
E
N
K
A
E
V
V
S
L
D
E
K
E
S
G
L
R
A
T
L
N
L
G
H
T
F
G
H
A
I
E
T
G
F
G
Y
-
G
Q
W
L
H
G
E
A
V
A
A
G
M
V
M
A
V
D
M
S
Y
R
L
G
W
I
D
E
S
I
V
N
R
A
H
N
I
L
Q
Q
A
K
L
P
T
A
P
P
-
E
-
T
-----------
M
-----------
T
V
E
M
-----------
F
K
-
S
V
M
A
V
D
K
K
V
A
-----
D
G
L
L
R
L
I
L
L
---------------------------------------
3
PsiBlast_PDB
77.04
38%
-26
- C3 -
-
3ZOK
5
DHQS_ACTCH
A:
[17-350]
--
V
D
V
D
L
G
D
R
S
Y
P
I
Y
I
G
S
G
L
L
D
Q
-
P
D
L
L
-
Q
R
H
V
-
H
G
----
K
R
V
L
V
V
T
N
S
T
V
A
P
I
Y
L
D
K
V
V
G
A
--
L
T
N
-
E
N
P
N
V
------
S
V
E
------
S
V
I
L
P
D
G
E
K
Y
K
N
M
D
T
L
M
K
V
F
D
K
A
I
E
S
R
--
L
D
R
-
R
C
T
F
-
V
A
L
G
G
G
V
I
G
D
M
C
G
Y
A
A
A
S
F
L
R
G
V
N
F
I
Q
I
P
T
T
V
M
A
Q
V
D
S
S
V
G
G
K
T
G
I
N
H
R
L
G
K
N
L
I
G
A
F
Y
Q
P
Q
C
V
L
I
D
T
D
T
L
N
T
L
P
D
R
E
L
A
S
G
L
A
E
V
V
K
Y
G
L
I
------
R
D
A
N
F
F
----
E
W
Q
E
K
N
M
-
P
A
-
L
M
A
R
D
P
--
S
---------------
A
L
--------
A
Y
A
----
I
---
K
---
R
---------------
S
C
E
N
K
A
E
V
V
S
L
D
E
K
E
S
G
L
R
A
T
L
N
L
G
H
T
F
G
H
A
I
E
T
G
F
G
Y
-
G
Q
W
L
H
G
E
A
V
A
A
G
M
V
M
A
V
D
M
S
Y
R
L
G
W
I
D
E
S
I
V
N
R
A
H
N
I
L
Q
Q
A
K
L
P
T
A
P
P
-
E
-
T
-----------
M
-----------
T
V
E
M
-----------
F
K
-
S
V
M
A
V
D
K
K
V
A
-----
D
G
L
L
R
L
I
L
L
---------------------------------------
23
PsiBlast_CBE
76.84
38%
-23
- C3 -
-
3ZOK
3
DHQS_ACTCH
C:
[17-350]
--
V
D
V
D
L
G
D
R
S
Y
P
I
Y
I
G
S
G
L
L
D
Q
-
P
D
L
L
-
Q
R
H
V
-
H
G
----
K
R
V
L
V
V
T
N
S
T
V
A
P
I
Y
L
D
K
V
VG
A
--
L
T
N
-
E
N
P
N
V
------
S
V
E
------
S
V
I
L
P
D
G
E
K
Y
K
N
M
D
T
L
M
K
V
F
D
K
A
I
E
S
R
--
L
D
R
-
R
C
T
F
-
V
A
L
G
G
G
V
I
G
D
M
C
G
Y
A
A
A
S
F
L
R
G
V
N
F
I
Q
I
P
T
T
V
M
A
Q
V
D
S
S
V
G
G
K
T
G
I
N
H
R
L
G
K
N
L
I
G
A
F
Y
Q
P
Q
C
V
L
I
D
T
D
T
L
N
T
L
P
D
R
E
L
A
S
G
L
A
E
V
V
K
Y
G
L
I
------
R
D
A
N
F
F
----
E
W
QEKN
M
-
P
A
-
L
M
A
R
D
P
--
S
---------------
A
L
--------
A
Y
A
----
I
---
K
---
R
---------------
S
C
E
N
K
A
E
V
V
S
L
D
E
K
E
S
G
L
R
A
T
L
N
L
G
H
T
F
G
H
A
I
E
T
G
F
G
Y
-
G
Q
W
L
H
G
E
A
V
A
A
G
M
V
M
A
V
D
M
S
Y
R
L
G
W
I
D
E
S
I
V
N
R
A
H
N
I
L
Q
Q
A
K
L
P
T
A
P
P
-
E
-
T
-----------
M
-----------
T
V
E
M
-----------
F
K
-
S
V
M
A
V
D
K
K
V
A
-----
D
G
L
L
R
L
I
L
L
---------------------------------------
24
PsiBlast_CBE
76.32
38%
-25
- C3 -
-
3ZOK
6
DHQS_ACTCH
B:
[17-350]
--
V
D
V
D
L
G
D
R
S
Y
P
I
Y
I
G
S
G
L
L
D
Q
-
P
D
L
L
-
Q
R
H
V
-
H
G
----
K
R
V
L
V
V
T
N
S
T
V
A
P
I
Y
L
D
K
V
VG
A
--
L
T
N
-
E
N
P
N
V
------
S
V
E
------
S
V
I
L
P
D
G
E
K
Y
K
N
M
D
T
L
M
K
V
F
D
K
A
I
E
S
R
--
L
D
R
-
R
C
T
F
-
V
A
L
G
G
G
V
I
G
D
M
C
G
Y
A
A
A
S
F
L
R
G
V
N
F
I
Q
I
P
T
T
V
M
A
Q
V
D
S
S
V
G
G
K
T
G
I
N
H
R
L
G
K
N
L
I
G
A
F
Y
Q
P
Q
C
V
L
I
D
T
D
T
L
N
T
L
P
D
R
E
L
A
S
G
L
A
E
V
V
K
Y
G
L
I
------
R
D
A
N
F
F
----
E
W
QEKN
M
-
P
A
-
L
M
A
R
D
P
--
S
---------------
A
L
--------
A
Y
A
----
I
---
K
---
R
---------------
S
C
E
N
K
A
E
V
V
S
L
D
E
K
E
S
G
L
R
A
T
L
N
L
G
H
T
F
G
H
A
I
E
T
G
F
G
Y
-
G
Q
W
L
H
G
E
A
V
A
A
G
M
V
M
A
V
D
M
S
Y
R
L
G
W
I
D
E
S
I
V
N
R
A
H
N
I
L
Q
Q
A
K
L
P
T
A
P
P
-
E
-
T
-----------
M
-----------
T
V
E
M
-----------
F
K
-
S
V
M
A
V
D
K
K
V
A
-----
D
G
L
L
R
L
I
L
L
---------------------------------------
16
PsiBlast_PDB
76.32
32%
-95
- C3 -
-
1XAH
1
AROB_STAAR
A:
[1-352]
M
K
L
Q
T
T
Y
P
S
N
N
Y
P
I
Y
V
E
H
G
A
I
K
Y
-
I
G
T
Y
-
L
N
Q
F
D
Q
S
-------
F
L
L
I
D
E
Y
V
N
Q
Y
F
A
N
K
F
--
D
-------
N
----------
V
H
------
K
V
I
I
P
A
G
E
K
T
K
T
F
E
Q
Y
Q
E
T
L
E
Y
I
L
S
H
H
--
V
T
R
-
N
T
A
I
-
I
A
V
G
G
G
A
T
G
D
F
A
G
F
V
A
A
T
L
L
R
G
V
H
F
I
Q
V
P
T
T
I
L
A
H
-
D
S
S
V
G
G
K
V
G
I
N
S
K
Q
G
K
N
L
I
G
A
F
Y
R
P
T
A
V
I
Y
D
L
D
F
L
K
T
L
P
F
K
Q
I
L
S
G
Y
A
E
V
Y
K
H
A
L
L
N
G
E
S
A
T
Q
D
I
E
Q
H
F
KD
R
E
I
----
L
-
Q
S
-
L
N
G
M
D
K
--
Y
---------------
I
A
--------
K
G
I
E
T
------------------------------
K
L
D
I
V
V
A
D
E
K
E
Q
G
V
R
K
F
L
N
L
G
H
T
F
G
H
A
V
E
Y
---
Y
-
H
K
I
P
H
G
H
A
V
M
V
G
I
I
Y
Q
F
I
V
A
N
A
L
F
D
S
K
H
D
I
S
H
Y
I
Q
Y
L
I
Q
-
L
G
Y
P
L
-
D
---------------------------------------------------------------
G
V
Q
M
V
L
M
R
Q
-
F
G
D
I
V
V
---
Q
H
------
V
D
Q
L
T
L
Q
H
A
C
E
Q
L
K
T
Y
---
5
PsiBlast_PDB
76.31
36%
-80
- C3 -
-
3QBE
-
AROB_MYCTU
A:
[44-341]
----------------------------------------
H
K
V
A
V
V
H
Q
P
G
L
A
E
-
T
A
E
E
I
--
R
--
K
R
L
-
A
G
K
G
V
------
D
A
H
------
R
I
E
I
P
D
A
E
A
G
K
D
L
P
V
V
G
F
I
W
E
V
L
G
R
I
G
--
I
G
R
-
K
D
A
L
-
V
S
L
G
G
G
A
A
T
D
V
A
G
F
A
A
A
T
W
L
R
G
V
S
I
V
H
L
P
T
T
L
L
G
M
V
D
A
A
V
G
G
K
T
G
I
N
T
D
A
G
K
N
L
V
G
A
F
H
Q
P
L
A
V
L
V
D
L
A
T
L
Q
T
L
P
R
D
E
M
I
C
G
M
A
E
V
V
K
A
G
F
I
------
A
D
P
V
I
L
----
D
L
----
I
-
E
A
D
P
Q
A
A
L
D
--
P
---------------
A
G
--------
D
V
L
P
E
L
-
I
---
R
---
R
---------------
A
I
T
V
K
A
E
V
V
A
A
----
S
E
L
R
E
I
L
N
Y
G
H
T
L
G
H
A
I
E
R
R
E
R
Y
--
R
W
R
H
G
A
A
V
S
V
G
L
V
F
A
A
E
L
A
R
L
A
G
R
L
D
D
A
T
A
Q
R
H
R
T
I
L
S
S
L
G
L
P
V
-
S
Y
-
D
-
P
-----------
D
-----------
A
L
P
Q
-----------
L
L
-
E
I
M
A
G
D
K
K
T
R
-----
A
G
V
L
R
F
V
V
L
---------------------------------------
21
PsiBlast_CBE
75.46
39%
-13
- C3 -
-
5EKS
1
?
B:
[32-349]
------------------------------
K
Q
L
L
E
P
YIHG
Q
Q
V
M
I
V
S
N
V
T
V
A
P
L
Y
L
S
H
Y
--
Q
--
E
A
L
-
E
S
L
G
K
------
T
V
A
------
T
C
I
L
P
D
G
E
K
Y
K
D
I
Q
H
L
N
L
I
F
D
A
L
L
E
A
G
--
F
N
R
-
D
C
T
V
-
L
A
L
G
G
G
V
I
G
D
M
A
G
F
A
S
A
C
F
Q
R
G
V
Y
F
V
Q
V
P
T
T
L
L
S
Q
V
D
S
S
V
G
G
K
T
G
I
N
H
P
L
G
K
N
M
L
G
A
F
Q
Q
P
Q
V
V
L
A
D
M
A
Q
L
N
T
L
P
E
R
E
L
S
A
G
L
A
E
V
I
K
Y
A
L
L
------
G
D
E
D
F
L
----
V
W
----
L
E
E
N
-
M
D
G
L
V
A
--
R
---------------
D
A
--------
D
L
L
A
E
A
-
V
---
Y
---
R
---------------
S
C
A
H
K
A
R
I
V
A
N
D
E
----
E
R
A
L
L
N
L
G
H
T
F
G
H
A
I
E
S
Y
L
G
Y
-
G
T
W
L
H
G
E
A
V
A
T
G
M
V
M
A
A
D
L
S
Q
R
L
G
W
I
S
N
E
D
V
A
R
T
K
K
I
I
Q
R
A
N
L
P
I
-
S
C
-
P
-
Q
-----------
I
-----------
P
L
D
D
-----------
F
L
-
G
Y
M
A
H
D
K
K
V
-------
G
Q
L
R
L
V
L
L
K
Q
-
L
G
Q
A
V
I
------------------------------
45
HHSearch
75.31
27%
-65
- C3 -
-
2GRU
5
DOIS_BACCI
A:
[3-366]
-
T
K
Q
I
C
F
A
D
R
C
F
N
F
A
F
G
E
H
V
L
E
S
-
V
E
S
Y
-
I
P
R
-
D
E
F
----
D
Q
Y
I
M
I
S
D
S
G
V
P
D
S
I
V
H
Y
A
--
A
--
E
Y
F
-
G
K
L
-
A
------
P
V
H
------
I
L
R
F
Q
G
G
E
E
Y
K
T
L
S
T
V
T
N
L
Q
E
R
A
I
A
L
G
--
A
N
R
-
R
T
A
I
-
V
A
V
G
G
G
L
T
G
N
V
A
G
V
A
A
G
M
M
F
R
G
I
A
L
I
H
V
P
T
T
F
L
A
A
S
D
S
V
L
S
I
K
Q
A
V
N
L
T
S
G
K
N
L
V
G
F
Y
Y
P
P
R
F
V
F
A
D
T
R
I
L
S
E
S
P
P
R
Q
V
K
A
G
M
C
E
L
V
K
N
M
L
I
------
L
E
N
D
N
K
----
E
F
----
T
-
E
D
-
D
L
N
S
A
N
V-
Y
---------------
S
P
--------
K
Q
L
E
T
F
-
I
---
N
---
F
---------------
C
I
S
A
K
M
S
V
L
S
E
D
I
Y
E
K
K
K
G
L
I
F
E
Y
G
H
T
I
G
H
A
I
E
L
A
E
Q
G
-
G
-
I
T
H
G
E
A
I
A
V
G
M
I
Y
A
A
K
I
A
N
R
M
N
L
M
P
E
H
D
V
S
A
H
Y
W
L
L
N
K
I
G
A
L
Q
-
D
I
-
P
-
L
K----------
S
-----------
D
P
D
S
-----------
I
F
-
H
Y
L
I
H
D
N
K
R
G
YIKLD
E
D
N
L
G
M
I
L
L
S
G
-
V
G
K
P
A
M
---
Y
N
QTL
L
T
P
V
-------
R
K
T
L
I
K
E
V
I
R
E
15
PsiBlast_PDB
74.21
32%
-31
- C3 -
-
1XAG
2
AROB_STAAR
A:
[1-353]
M
K
L
Q
T
T
Y
P
S
N
N
Y
P
I
Y
V
E
H
G
A
I
K
Y
-
I
G
T
Y
-
L
N
Q
F
D
Q
S
-------
F
L
L
I
D
E
Y
V
N
Q
Y
F
A
N
K
F
--
D
D
I
L
S
Y
-
E
N
----------
V
H
------
K
V
I
I
P
A
G
E
K
T
K
T
F
E
Q
Y
Q
E
T
L
E
Y
I
L
S
H
H
--
V
T
R
-
N
T
A
I
-
I
A
V
G
G
G
A
T
G
D
F
A
G
F
V
A
A
T
L
L
R
G
V
H
F
I
Q
V
P
T
T
I
L
A
H
-
D
S
S
V
G
G
K
V
G
I
N
S
K
Q
G
K
N
L
I
G
A
F
Y
R
P
T
A
V
I
Y
D
L
D
F
L
K
T
L
P
F
K
Q
I
L
S
G
Y
A
E
V
Y
K
H
A
L
L
N
G
E
S
A
T
Q
D
I
E
Q
H
FKD
R
E
I
----
L
-
Q
S
-
L
N
G
M
D
K
--
Y
---------------
I
A
--------
K
G
I
E
T
------------------------------
K
L
D
I
V
V
A
D
E
K
E
Q
G
V
R
K
F
L
N
L
G
H
T
F
G
H
A
V
E
Y
---
Y
-
H
K
I
P
H
G
H
A
V
M
V
G
I
I
Y
Q
F
I
V
A
N
A
L
F
D
S
K
H
D
I
S
H
Y
I
Q
Y
L
I
Q
-
L
G
Y
P
L
-
D
M
I
T
-
D
-----------
L
-----------
D
F
E
T
-----------
L
Y
-
Q
Y
M
L
S
D
K
K
N
D
-----
K
Q
G
V
Q
M
V
L
M
R
Q
-
F
G
D
I
V
V
---
Q
H
------
V
D
Q
L
T
L
Q
H
A
C
E
Q
L
K
T
Y
F
--
2
PsiBlast_PDB
73.94
39%
-16
- C3 -
-
5EKS
1
?
A:
[32-349]
------------------------------
K
Q
L
L
E
P
YIHG
Q
Q
V
M
I
V
S
N
V
T
V
A
P
L
Y
L
S
H
Y
--
Q
--
E
A
L
-
E
S
L
G
K
------
T
V
A
------
T
C
I
L
P
D
G
E
K
Y
K
D
I
Q
H
L
N
L
I
F
D
A
L
L
E
A
G
--
F
N
R
-
D
C
T
V
-
L
A
L
G
G
G
V
I
G
D
M
A
G
F
A
S
A
C
F
Q
R
G
V
Y
F
V
Q
V
P
T
T
L
L
S
Q
V
D
S
S
V
G
G
K
T
G
I
N
H
P
L
G
K
N
M
L
G
A
F
Q
Q
P
Q
V
V
L
A
D
M
A
Q
L
N
T
L
P
E
R
E
L
S
A
G
L
A
E
V
I
K
Y
A
L
L
------
G
D
E
D
F
L
----
V
W
----
L
E
E
N
-
M
D
G
L
V
A
--
R
---------------
D
A
--------
D
L
L
A
E
A
-
V
---
Y
---
R
---------------
S
C
A
H
K
A
R
I
V
A
N
D
E
K
E
---
R
A
L
L
N
L
G
H
T
F
G
H
A
I
E
S
Y
L
G
Y
-
G
T
W
L
H
G
E
A
V
A
T
G
M
V
M
A
A
D
L
S
Q
R
L
G
W
I
S
N
E
D
V
A
R
T
K
K
I
I
Q
R
A
N
L
P
I
-
S
C
-
P
-
Q
-----------
I
-----------
P
L
D
D
-----------
F
L
-
G
Y
M
A
H
D
K
K
V
--------
Q
L
R
L
V
L
L
K
Q
-
L
G
Q
A
V
I
------------------------------
43
HHSearch
73.77
30%
-74
- C3 -
-
1XAH
1
AROB_STAAR
B:
[1-347]
M
K
L
Q
T
T
Y
P
S
N
N
Y
P
I
Y
V
E
H
G
A
I
K
Y
-
I
G
T
Y
-
L
N
Q
---
F
----
D
Q
S
F
L
L
I
D
E
Y
V
N
Q
Y
F
A
N
K
F
--
D
---------
N
--------
V
H
------
K
V
I
I
P
A
G
E
K
T
K
T
F
E
Q
Y
Q
E
T
L
E
Y
I
L
S
H
H
--
V
T
R
-
N
T
A
I
-
I
A
V
G
G
G
A
T
G
D
F
A
G
F
V
A
A
T
L
L
R
G
V
H
F
I
Q
V
P
T
T
I
L
A
H
-
D
S
S
V
G
G
K
V
G
I
N
S
K
Q
G
K
N
L
I
G
A
F
Y
R
P
T
A
V
I
Y
D
L
D
F
L
K
T
L
P
F
K
Q
I
L
S
G
Y
A
E
V
Y
K
H
A
L
L
------
N
G
E
S
A
T
----
Q
D
----
I
-
E
Q
-
H
F
K
D
R
E
IL
Q
---------------
S
L
--------
N
G
M
D
K
Y
-
I
---
A
---
K
---------------
G
I
E
T
K
L
D
I
V
V
A
D
E
K
E
Q
G
V
R
K
F
L
N
L
G
H
T
F
G
H
A
V
E
Y
Y
--
H
-
K
-
I
P
H
G
H
A
V
M
V
G
I
I
Y
Q
F
I
V
A
N
A
L
F
D
-
S
K
H
D
I
S
H
Y
I
Q
Y
L
I
Q
L
G
Y
P
L
-
D
-------------------------------
T
-----------
L
Y
-
Q
Y
M
L
-------------
G
V
Q
M
V
L
M
R
Q
-
F
G
D
I
V
V
---
Q
H
------
V
-------
D
Q
L
T
L
Q
H
A
C
E
-
4
PsiBlast_PDB
72.38
38%
-39
- C3 -
-
5HVN
1
AROB_FRATT
A:
[33-358]
-------------------------------
E
Y
V
T
N
----
K
Q
V
L
V
V
T
N
T
T
V
A
K
L
Y
L
T
K
F
--
L
--
A
A
L
V
D
D
L
D
V
------
R
T
C
------
I
L
E
--
D
G
E
Q
Y
K
S
Q
Q
S
L
D
K
I
L
S
T
L
L
E
N
H
--
F
T
R
-
N
S
T
V
L
V
A
L
G
G
G
V
I
G
D
I
T
G
F
A
A
A
I
Y
Q
R
G
I
D
F
I
Q
I
P
T
T
L
L
S
Q
V
D
S
S
V
G
G
K
T
A
I
N
H
Q
L
G
K
N
M
I
G
A
F
Y
Q
P
K
V
V
Y
T
S
I
E
F
Y
K
T
L
P
Q
R
E
Y
I
A
G
M
A
E
V
V
K
Y
A
F
I
S
-----
K
D
F
Y
L
W
---------------
L
D
S
N
R
D
--
K
---------------
I
L
A
-------
K
D
S
V
T
L
-
I
---
E
M
V
K
R
---------------
S
C
Q
I
K
A
Q
V
V
A
M
D
---
T
G
A
R
A
I
L
N
F
G
H
T
F
G
H
A
I
E
K
C
Q
N
Y
-
R
G
L
K
H
G
E
A
V
G
V
G
M
A
Q
A
I
D
F
S
H
Y
L
G
L
I
S
Q
Q
Q
A
K
D
F
N
D
F
I
V
S
F
G
I
S
I
-
D
F
-
P
-
N
-----------
D
-----------
I
C
Q
K
-----------
E
F
L
E
A
M
L
L
D
---------
N
K
E
L
K
F
I
L
I
E
N
-
I
G
S
L
S
L
---
Q
K
------
Q
-------
S
K
N
E
L
E
Q
F
L
--
63
Fugue
71.32
35%
1
- C3 -
-
1DQS
3
ARO1_EMENI
A:
[4-391]
-
P
T
K
I
S
I
-
L
G
R
E
S
I
I
A
D
F
G
L
W
R
N
Y
V
A
K
D
-
L
I
S
D
C
S
S
----
T
T
Y
V
L
V
T
D
T
N
I
G
S
I
Y
T
P
S
F
--
E
--
E
A
F
-
R
K
R
A
A
EITP
S
P
R
L
L
------
I
Y
N
R
P
P
G
E
V
S
K
S
R
Q
T
K
A
D
I
E
D
W
M
L
S
Q
N
PP
C
G
R
-
D
T
V
V
-
I
A
L
G
G
G
V
I
G
D
L
T
G
F
V
A
S
T
Y
M
R
G
V
R
Y
V
Q
V
P
T
T
L
L
A
M
V
D
S
S
I
G
G
K
T
A
I
D
T
P
L
G
K
N
L
I
G
A
I
W
Q
P
T
K
I
Y
I
D
L
E
F
L
E
T
L
P
V
R
E
F
I
N
G
M
A
E
V
I
K
T
A
A
I
------
S
S
E
E
E
F
----
T
A
----
L
-
E
E
-
N
A
E
T
I
L
--
K
---------------
A
V
R
RRFEGT
E
E
I
L
K
A
R
-
I
---
L
---
A
---------------
S
A
R
H
K
A
Y
V
V
S
A
D
E
R
E
G
G
L
R
N
L
L
N
W
G
H
S
I
G
H
A
I
E
A
I
L
T
P
--
Q
I
L
H
G
E
C
V
A
I
G
M
V
K
E
A
E
L
A
R
H
L
G
I
L
K
G
V
A
V
S
R
I
V
K
C
L
A
A
Y
G
L
P
T
-
S
L
-
K
-
D
-----------
A
-----------
R
I
R
K
L
TAGKHCS
V
D
Q
L
M
-
F
N
M
A
L
D
K
K
N
D
-----
G
P
K
K
K
I
V
L
L
S
A
-
I
G
T
P
Y
E
T
R
A
S
V
------
V
-------
A
N
E
D
I
R
V
V
L
--
17
PsiBlast_PDB
71.23
32%
-32
- C3 -
-
1XAI
2
AROB_STAAR
A:
[1-352]
M
K
L
Q
T
T
Y
P
S
N
N
Y
P
I
Y
V
E
H
G
A
I
K
Y
-
I
G
T
Y
-
L
N
Q
F
D
Q
S
-------
F
L
L
I
D
E
Y
V
N
Q
Y
F
A
N
K
F
--
D
DI
L
S
Y
-
E
N
----------
V
H
------
K
V
I
I
P
A
G
E
K
T
K
T
F
E
Q
Y
Q
E
T
L
E
Y
I
L
S
H
H
--
V
T
R
-
N
T
A
I
-
I
A
V
G
G
G
A
T
G
D
F
A
G
F
V
A
A
T
L
L
R
G
V
H
F
I
Q
V
P
T
T
I
L
A
H
-
D
S
S
V
G
G
K
V
G
I
N
S
K
Q
G
K
N
L
I
G
A
F
Y
R
P
T
A
V
I
Y
D
L
D
F
L
K
T
L
P
F
K
Q
I
L
S
G
Y
A
E
V
Y
K
H
A
L
L
N
G
E
S
A
T
Q
D
I
E
Q
H
F
KD
R
E
I
----
L
-
Q
S
-
L
N
G
M
D
K
--
Y
---------------
I
A
--------
K
G
I
E
T
------------------------------
K
L
D
I
V
V
A
D
E
K
E
Q
G
V
R
K
F
L
N
L
G
H
T
F
G
H
A
V
E
Y
---
Y
-
H
K
I
P
H
G
H
A
V
M
V
G
I
I
Y
Q
F
I
V
A
N
A
L
F
D
S
K
H
D
I
S
H
Y
I
Q
Y
L
I
Q
-
L
G
Y
P
L
-
D
M
I
T
-
D
-----------
L
-----------
D
F
E
T
-----------
L
Y
-
Q
Y
M
L
S
D
K
K
N
D
-----
K
Q
G
V
Q
M
V
L
M
R
Q
-
F
G
D
I
V
V
---
Q
H
------
V
D
Q
L
T
L
Q
H
A
C
E
Q
L
K
T
Y
---
54
HHSearch
69.90
35%
1
- C3 -
-
1SG6
1
ARO1_EMENI
B:
[9-392]
-------
I
L
G
R
E
S
I
I
A
D
F
G
L
W
R
N
Y
V
A
K
D
L
I
S
D
-
C
S
S
----
T
T
Y
V
L
V
T
D
T
N
I
G
S
I
Y
T
P
S
F
--
E
--
E
A
F
-
R
K
R
A
A
E
I
TP
S
P
R
L
L
------
I
Y
N
R
P
P
G
E
V
S
K
S
R
Q
T
K
A
D
I
E
D
W
M
L
S
Q
N
PP
C
G
R
-
D
T
V
V
-
I
A
L
G
G
G
V
I
G
D
L
T
G
F
V
A
S
T
Y
M
R
G
V
R
Y
V
Q
V
P
T
T
L
L
A
M
V
D
S
S
I
G
G
K
T
A
I
D
T
P
L
G
K
N
L
I
G
A
I
W
Q
P
T
K
I
Y
I
D
L
E
F
L
E
T
L
P
V
R
E
F
I
N
G
M
A
E
V
I
K
T
A
A
I
------
S
S
E
E
E
F
----
T
A
----
L
-
E
E
-
N
A
E
T
I
L
--
K
A
V
R
R
E
V
T
PGEHRFEG
T
E
--------
E
I
L
K
A
R
-
I
---
L
---
A
---------------
S
A
R
H
K
A
Y
V
V
S
A
----
G
G
L
R
N
L
L
N
W
G
H
S
I
G
H
A
I
E
A
I
L
T
P
-
Q
-
I
L
H
G
E
C
V
A
I
G
M
V
K
E
A
E
L
A
R
H
L
G
I
L
K
G
V
A
V
S
R
I
V
K
C
L
A
A
Y
G
L
P
T
-
S
L
-
K
-
D
-----------
A
R
I
R
K
L
T
AG
K
H
C
S
V
D
Q
-----------
L
M
-
F
N
M
A
L
-------------
K
K
I
V
L
L
S
A
-
I
G
T
P
Y
E
---
T
R
A
S
V
---
V
-------
A
N
E
D
I
R
V
V
L
A
-
37
PsiBlast_CBE
69.76
32%
-31
- C3 -
-
1XAI
2
AROB_STAAR
B:
[1-352]
M
K
L
Q
T
T
Y
P
S
N
N
Y
P
I
Y
V
E
H
G
A
I
K
Y
-
I
G
T
Y
-
L
N
Q
F
D
Q
S
-------
F
L
L
I
D
E
Y
V
N
Q
Y
F
A
N
K
F
--
D
DI
L
S
Y
-
E
N
----------
V
H
------
K
V
I
I
P
A
G
E
K
T
K
T
F
E
Q
Y
Q
E
T
L
E
Y
I
L
S
H
H
--
V
T
R
-
N
T
A
I
-
I
A
V
G
G
G
A
T
G
D
F
A
G
F
V
A
A
T
L
L
R
G
V
H
F
I
Q
V
P
T
T
I
L
A
H
-
D
S
S
V
G
G
K
V
G
I
N
S
K
Q
G
K
N
L
I
G
A
F
Y
R
P
T
A
V
I
Y
D
L
D
F
L
K
T
L
P
F
K
Q
I
L
S
G
Y
A
E
V
Y
K
H
A
L
L
NGESAT
Q
D
I
E
Q
H
FKDR
E
I
----
L
-
Q
S
-
L
N
G
M
D
K
--
Y
---------------
I
A
--------
K
G
I
E
T
------------------------------
K
L
D
I
V
V
A
D
E
K
E
Q
G
V
R
K
F
L
N
L
G
H
T
F
G
H
A
V
E
Y
---
Y
-
H
K
I
P
H
G
H
A
V
M
V
G
I
I
Y
Q
F
I
V
A
N
A
L
F
D
S
K
H
D
I
S
H
Y
I
Q
Y
L
I
Q
-
L
G
Y
P
L
-
D
M
I
T
-
D
-----------
L
-----------
D
F
E
T
-----------
L
Y
-
Q
Y
M
L
S
D
K
K
N
D
-----
K
Q
G
V
Q
M
V
L
M
R
Q
-
F
G
D
I
V
V
---
Q
H
------
V
DQLTLQH
A
C
E
Q
L
K
T
Y
---
55
HHSearch
68.90
35%
10
- C3 -
-
1NVB
1
ARO1_EMENI
B:
[9-392]
-------
I
L
G
R
E
S
I
I
A
D
F
G
L
W
R
N
Y
V
A
K
D
L
I
S
D
-
C
S
S
----
T
T
Y
V
L
V
T
D
T
N
I
G
S
I
Y
T
P
S
F
--
E
--
E
A
F
-
R
K
R
A
A
EITPSP
R
L
L
------
I
Y
N
R
P
P
G
E
V
S
K
S
R
Q
T
K
A
D
I
E
D
W
M
L
S
Q
N
PP
C
G
R
-
D
T
V
V
-
I
A
L
G
G
G
V
I
G
D
L
T
G
F
V
A
S
T
Y
M
R
G
V
R
Y
V
Q
V
P
T
T
L
L
A
M
V
D
S
S
I
G
G
K
T
A
I
D
T
P
L
G
K
N
L
I
G
A
I
W
Q
P
T
K
I
Y
I
D
L
E
F
L
E
T
L
P
V
R
E
F
I
N
G
M
A
E
V
I
K
T
A
A
I
------
S
S
E
E
E
F
----
T
A
----
L
-
E
E
-
N
A
E
T
I
L
--
K
AVRREVTPGEHRFEG
T
E
--------
E
I
L
K
A
R
-
I
---
L
---
A
---------------
S
A
R
H
K
A
Y
V
V
S
A
D
E
R
E
G
G
L
R
N
L
L
N
W
G
H
S
I
G
H
A
I
E
A
I
L
T
P
-
Q
-
I
L
H
G
E
C
V
A
I
G
M
V
K
E
A
E
L
A
R
H
L
G
I
L
K
G
V
A
V
S
R
I
V
K
C
L
A
A
Y
G
L
P
T
-
S
L
-
K
-
D
-----------
A
RIRKLTAGKHC
S
V
D
Q
-----------
L
M
-
F
N
M
A
L
D
K
K
N
D
-----
G
P
K
K
K
I
V
L
L
S
A
-
I
G
T
P
Y
E
---
T
R
ASV---
V
-------
A
N
E
D
I
R
V
V
L
A
-
14
PsiBlast_PDB
65.70
35%
-16
- C3 -
-
1SG6
1
ARO1_EMENI
A:
[40-373]
-------------------------------------------
V
L
V
T
D
T
N
I
G
S
I
Y
T
P
S
F
--
E
--
E
A
F
-
R
K
R
A
A
------
E
I
T
P
S
P
R
L
L
I
Y
N
R
P
P
G
E
V
S
K
S
R
Q
T
K
A
D
I
E
D
W
M
L
S
Q
N
PP
C
G
R
-
D
T
V
V
-
I
A
L
G
G
G
V
I
G
D
L
T
G
F
V
A
S
T
Y
M
R
G
V
R
Y
V
Q
V
P
T
T
L
L
A
M
V
D
S
S
I
G
G
K
T
A
I
D
T
P
L
G
K
N
L
I
G
A
I
W
Q
P
T
K
I
Y
I
D
L
E
F
L
E
T
L
P
V
R
E
F
I
N
G
M
A
E
V
I
K
T
A
A
I
------
S
S
E
E
E
F
------------
T
A
-
L
E
E
N
A
E
--
T
---------------
I
L
--------
K
A
V
R
R
E
-
V
T
PG
E
---
H
RFEGT
E
E
I
L
K
A
R
I
L
A
S
A
R
H
K
A
Y
V
V
S
A
-----
G
L
R
N
L
L
N
W
G
H
S
I
G
H
A
I
E
A
I
L
-
T
-
P
Q
I
L
H
G
E
C
V
A
I
G
M
V
K
E
A
E
L
A
R
H
L
G
I
L
K
G
V
A
V
S
R
I
V
K
C
L
A
A
Y
G
L
P
T
-
S
L
-
K
-
D
A
R
I
R
K
L
T
AGKH
C
-----------
S
V
D
Q
-----------
L
M
-
F
N
M
A
L
D
------------
K
K
I
V
L
L
S
A
-
I
G
T
---------------------------------
7
PsiBlast_PDB
65.17
35%
0
- C3 -
-
1NR5
2
ARO1_EMENI
A:
[40-373]
-------------------------------------------
V
L
V
T
D
T
N
I
G
S
I
Y
T
P
S
F
--
E
--
E
A
F
-
R
K
R
A
A
------
E
I
T
P
S
P
R
L
L
I
Y
N
R
P
P
G
E
V
S
K
S
R
Q
T
K
A
D
I
E
D
W
M
L
S
Q
N
PP
C
G
R
-
D
T
V
V
-
I
A
L
G
G
G
V
I
G
D
L
T
G
F
V
A
S
T
Y
M
R
G
V
R
Y
V
Q
V
P
T
T
L
L
A
M
V
D
S
S
I
G
G
K
T
A
I
D
T
P
L
G
K
N
L
I
G
A
I
W
Q
P
T
K
I
Y
I
D
L
E
F
L
E
T
L
P
V
R
E
F
I
N
G
M
A
E
V
I
K
T
A
A
I
------
S
S
E
E
E
F
------------
T
A
-
L
E
E
N
A
E
--
T
---------------
I
L
--------
K
A
V
R
R
E
-
V
T
PG
E
---
H
RFEGT
E
E
I
L
K
A
R
I
L
A
S
A
R
H
K
A
Y
V
V
S
A
D
E
R
E
G
G
L
R
N
L
L
N
W
G
H
S
I
G
H
A
I
E
A
I
L
-
T
-
P
Q
I
L
H
G
E
C
V
A
I
G
M
V
K
E
A
E
L
A
R
H
L
G
I
L
K
G
V
A
V
S
R
I
V
K
C
L
A
A
Y
G
L
P
T
-
S
L
-
K
-
D
A
R
I
R
K
L
T
AG
K
H
C
-----------
S
V
D
Q
-----------
L
M
-
F
N
M
A
L
D
K
K
N
D
-----
G
P
K
K
K
I
V
L
L
S
A
-
I
G
T
---------------------------------
25
PsiBlast_CBE
64.83
35%
-17
- C3 -
-
1SG6
1
ARO1_EMENI
B:
[40-373]
-------------------------------------------
V
L
V
T
D
T
N
I
G
S
I
Y
T
P
S
F
--
E
--
E
A
F
-
R
K
R
A
A
------
E
I
T
P
S
P
R
L
L
I
Y
N
R
P
P
G
E
V
S
K
S
R
Q
T
K
A
D
I
E
D
W
M
L
S
Q
N
PP
C
G
R
-
D
T
V
V
-
I
A
L
G
G
G
V
I
G
D
L
T
G
F
V
A
S
T
Y
M
R
G
V
R
Y
V
Q
V
P
T
T
L
L
A
M
V
D
S
S
I
G
G
K
T
A
I
D
T
P
L
G
K
N
L
I
G
A
I
W
Q
P
T
K
I
Y
I
D
L
E
F
L
E
T
L
P
V
R
E
F
I
N
G
M
A
E
V
I
K
T
A
A
I
------
S
S
E
E
E
F
------------
T
A
-
L
E
E
N
A
E
--
T
---------------
I
L
--------
K
A
V
R
R
E
-
V
T
PG
E
---
H
RFEGT
E
E
I
L
K
A
R
I
L
A
S
A
R
H
K
A
Y
V
V
S
A
----
G
G
L
R
N
L
L
N
W
G
H
S
I
G
H
A
I
E
A
I
L
-
T
-
P
Q
I
L
H
G
E
C
V
A
I
G
M
V
K
E
A
E
L
A
R
H
L
G
I
L
K
G
V
A
V
S
R
I
V
K
C
L
A
A
Y
G
L
P
T
-
S
L
-
K
-
D
A
R
I
R
K
L
T
AG
K
H
C
-----------
S
V
D
Q
-----------
L
M
-
F
N
M
A
L
-------------
K
K
I
V
L
L
S
A
-
I
G
T
---------------------------------
35
PsiBlast_CBE
64.20
35%
0
- C3 -
-
1NR5
2
ARO1_EMENI
B:
[40-373]
-------------------------------------------
V
L
V
T
D
T
N
I
G
S
I
Y
T
P
S
F
--
E
--
E
A
F
-
R
K
R
A
A
------
E
I
T
P
S
P
R
L
L
I
Y
N
R
P
P
G
E
V
S
K
S
R
Q
T
K
A
D
I
E
D
W
M
L
S
Q
N
PP
C
G
R
-
D
T
V
V
-
I
A
L
G
G
G
V
I
G
D
L
T
G
F
V
A
S
T
Y
M
R
G
V
R
Y
V
Q
V
P
T
T
L
L
A
M
V
D
S
S
I
G
G
K
T
A
I
D
T
P
L
G
K
N
L
I
G
A
I
W
Q
P
T
K
I
Y
I
D
L
E
F
L
E
T
L
P
V
R
E
F
I
N
G
M
A
E
V
I
K
T
A
A
I
------
S
S
E
E
E
F
------------
T
A
-
L
E
E
N
A
E
--
T
---------------
I
L
--------
K
A
V
R
R
E
-
V
T
P
G
E
---
H
RFEGT
E
E
I
L
K
A
R
I
L
A
S
A
R
H
K
A
Y
V
V
S
A
D
E
R
E
G
G
L
R
N
L
L
N
W
G
H
S
I
G
H
A
I
E
A
I
L
-
T
-
P
Q
I
L
H
G
E
C
V
A
I
G
M
V
K
E
A
E
L
A
R
H
L
G
I
L
K
G
V
A
V
S
R
I
V
K
C
L
A
A
Y
G
L
P
T
-
S
L
-
K
-
D
A
R
I
R
K
L
T
AGKH
C
-----------
S
V
D
Q
-----------
L
M
-
F
N
M
A
L
D
K
K
N
D
-----
G
P
K
K
K
I
V
L
L
S
A
-
I
G
T
---------------------------------
27
PsiBlast_CBE
64.16
35%
1
- C3 -
-
1NVF
3
ARO1_EMENI
B:
[40-373]
-------------------------------------------
V
L
V
T
D
T
N
I
G
S
I
Y
T
P
S
F
--
E
--
E
A
F
-
R
K
R
A
A
------
E
I
T
PSPRLL
I
Y
N
R
P
P
G
E
V
S
K
S
R
Q
T
K
A
D
I
E
D
W
M
L
S
Q
N
PP
C
G
R
-
D
T
V
V
-
I
A
L
G
G
G
V
I
G
D
L
T
G
F
V
A
S
T
Y
M
R
G
V
R
Y
V
Q
V
P
T
T
L
L
A
M
V
D
S
S
I
G
G
K
T
A
I
D
T
P
L
G
K
N
L
I
G
A
I
W
Q
P
T
K
I
Y
I
D
L
E
F
L
E
T
L
P
V
R
E
F
I
N
G
M
A
E
V
I
K
T
A
A
I
------
S
S
E
E
E
F
------------
T
A
-
L
E
E
N
A
E
--
T
---------------
I
L
--------
K
A
V
R
R
E
-
V
TPG
E
---
H
RFEGTEEILKARILA
S
A
R
H
K
A
Y
V
V
S
A
D
E
R
E
G
G
L
R
N
L
L
N
W
G
H
S
I
G
H
A
I
E
A
I
L
-
T
-
P
Q
I
L
H
G
E
C
V
A
I
G
M
V
K
E
A
E
L
A
R
H
L
G
I
L
K
G
V
A
V
S
R
I
V
K
C
L
A
A
Y
G
L
P
T
-
S
L
-
K
-
D
ARIRKLTAGKH
C
-----------
S
V
D
Q
-----------
L
M
-
F
N
M
A
L
D
K
K
N
D
-----
G
P
K
K
K
I
V
L
L
S
A
-
I
G
T
---------------------------------
11
PsiBlast_PDB
64.02
35%
-3
- C3 -
-
1NVB
2
ARO1_EMENI
A:
[40-373]
-------------------------------------------
V
L
V
T
D
T
N
I
G
S
I
Y
T
P
S
F
--
E
--
E
A
F
-
R
K
R
A
A
------
E
I
T
P
S
P
R
L
L
I
Y
N
R
P
P
G
E
V
S
K
S
R
Q
T
K
A
D
I
E
D
W
M
L
S
Q
N
PP
C
G
R
-
D
T
V
V
-
I
A
L
G
G
G
V
I
G
D
L
T
G
F
V
A
S
T
Y
M
R
G
V
R
Y
V
Q
V
P
T
T
L
L
A
M
V
D
S
S
I
G
G
K
T
A
I
D
T
P
L
G
K
N
L
I
G
A
I
W
Q
P
T
K
I
Y
I
D
L
E
F
L
E
T
L
P
V
R
E
F
I
N
G
M
A
E
V
I
K
T
A
A
I
------
S
S
E
E
E
F
------------
T
A
-
L
E
E
N
A
E
--
T
---------------
I
L
--------
K
A
V
R
R
E
-
V
TPG
E
---
H
RFEGT
E
E
I
L
K
A
R
I
L
A
S
A
R
H
K
A
Y
V
V
S
A
D
E
R
E
G
G
L
R
N
L
L
N
W
G
H
S
I
G
H
A
I
E
A
I
L
-
T
-
P
Q
I
L
H
G
E
C
V
A
I
G
M
V
K
E
A
E
L
A
R
H
L
G
I
L
K
G
V
A
V
S
R
I
V
K
C
L
A
A
Y
G
L
P
T
-
S
L
-
K
-
D
A
R
I
R
K
L
T
AG
K
H
C
-----------
S
V
D
Q
-----------
L
M
-
F
N
M
A
L
D
K
K
N
D
-----
G
P
K
K
K
I
V
L
L
S
A
-
I
G
T
---------------------------------
31
PsiBlast_CBE
63.93
35%
-4
- C3 -
-
1NVB
1
ARO1_EMENI
B:
[40-373]
-------------------------------------------
V
L
V
T
D
T
N
I
G
S
I
Y
T
P
S
F
--
E
--
E
A
F
-
R
K
R
A
A
------
E
I
T
PSPRLL
I
Y
N
R
P
P
G
E
V
S
K
S
R
Q
T
K
A
D
I
E
D
W
M
L
S
Q
N
PP
C
G
R
-
D
T
V
V
-
I
A
L
G
G
G
V
I
G
D
L
T
G
F
V
A
S
T
Y
M
R
G
V
R
Y
V
Q
V
P
T
T
L
L
A
M
V
D
S
S
I
G
G
K
T
A
I
D
T
P
L
G
K
N
L
I
G
A
I
W
Q
P
T
K
I
Y
I
D
L
E
F
L
E
T
L
P
V
R
E
F
I
N
G
M
A
E
V
I
K
T
A
A
I
------
S
S
E
E
E
F
------------
T
A
-
L
E
E
N
A
E
--
T
---------------
I
L
--------
K
A
V
R
R
E
-
V
TPG
E
---
H
RFEGTEEILKARILA
S
A
R
H
K
A
Y
V
V
S
A
D
E
R
E
G
G
L
R
N
L
L
N
W
G
H
S
I
G
H
A
I
E
A
I
L
-
T
-
P
Q
I
L
H
G
E
C
V
A
I
G
M
V
K
E
A
E
L
A
R
H
L
G
I
L
K
G
V
A
V
S
R
I
V
K
C
L
A
A
Y
G
L
P
T
-
S
L
-
K
-
D
ARIRKLTAGKH
C
-----------
S
V
D
Q
-----------
L
M
-
F
N
M
A
L
D
K
K
N
D
-----
G
P
K
K
K
I
V
L
L
S
A
-
I
G
T
---------------------------------
6
PsiBlast_PDB
63.85
35%
3
- C3 -
-
1DQS
3
ARO1_EMENI
A:
[40-373]
-------------------------------------------
V
L
V
T
D
T
N
I
G
S
I
Y
T
P
S
F
--
E
--
E
A
F
-
R
K
R
A
A
------
E
I
T
P
S
P
R
L
L
I
Y
N
R
P
P
G
E
V
S
K
S
R
Q
T
K
A
D
I
E
D
W
M
L
S
Q
N
PP
C
G
R
-
D
T
V
V
-
I
A
L
G
G
G
V
I
G
D
L
T
G
F
V
A
S
T
Y
M
R
G
V
R
Y
V
Q
V
P
T
T
L
L
A
M
V
D
S
S
I
G
G
K
T
A
I
D
T
P
L
G
K
N
L
I
G
A
I
W
Q
P
T
K
I
Y
I
D
L
E
F
L
E
T
L
P
V
R
E
F
I
N
G
M
A
E
V
I
K
T
A
A
I
------
S
S
E
E
E
F
------------
T
A
-
L
E
E
N
A
E
--
T
---------------
I
L
--------
K
A
V
R
R
-----------RFEGT
E
E
I
L
K
A
R
I
L
A
S
A
R
H
K
A
Y
V
V
S
A
D
E
R
E
G
G
L
R
N
L
L
N
W
G
H
S
I
G
H
A
I
E
A
I
L
-
T
-
P
Q
I
L
H
G
E
C
V
A
I
G
M
V
K
E
A
E
L
A
R
H
L
G
I
L
K
G
V
A
V
S
R
I
V
K
C
L
A
A
Y
G
L
P
T
-
S
L
-
K
-
D
A
R
I
R
K
L
TAGKH
C
-----------
S
V
D
Q
-----------
L
M
-
F
N
M
A
L
D
K
K
N
D
-----
G
P
K
K
K
I
V
L
L
S
A
-
I
G
T
---------------------------------
26
PsiBlast_CBE
63.80
35%
1
- C3 -
-
1NVF
2
ARO1_EMENI
C:
[40-373]
-------------------------------------------
V
L
V
T
D
T
N
I
G
S
I
Y
T
P
S
F
--
E
--
E
A
F
-
R
K
R
A
A
------
E
I
T
PSPRLL
I
Y
N
R
P
P
G
E
V
S
K
S
R
Q
T
K
A
D
I
E
D
W
M
L
S
Q
N
PP
C
G
R
-
D
T
V
V
-
I
A
L
G
G
G
V
I
G
D
L
T
G
F
V
A
S
T
Y
M
R
G
V
R
Y
V
Q
V
P
T
T
L
L
A
M
V
D
S
S
I
G
G
K
T
A
I
D
T
P
L
G
K
N
L
I
G
A
I
W
Q
P
T
K
I
Y
I
D
L
E
F
L
E
T
L
P
V
R
E
F
I
N
G
M
A
E
V
I
K
T
A
A
I
------
S
S
E
E
E
F
------------
T
A
-
L
E
E
N
A
E
--
T
---------------
I
L
--------
K
A
V
R
R
E
-
V
TPG
E
---
H
RFEGTEEILKARILA
S
A
R
H
K
A
Y
V
V
S
A
D
E
R
E
G
G
L
R
N
L
L
N
W
G
H
S
I
G
H
A
I
E
A
I
L
-
T
-
P
Q
I
L
H
G
E
C
V
A
I
G
M
V
K
E
A
E
L
A
R
H
L
G
I
L
K
G
V
A
V
S
R
I
V
K
C
L
A
A
Y
G
L
P
T
-
S
L
-
K
-
D
ARIRKLTAGKH
C
-----------
S
V
D
Q
-----------
L
M
-
F
N
M
A
L
D
K
K
N
D
-----
G
P
K
K
K
I
V
L
L
S
A
-
I
G
T
---------------------------------
12
PsiBlast_PDB
63.79
35%
-4
- C3 -
-
1NVD
2
ARO1_EMENI
A:
[40-373]
-------------------------------------------
V
L
V
T
D
T
N
I
G
S
I
Y
T
P
S
F
--
E
--
E
A
F
-
R
K
R
A
A
------
E
I
T
P
S
P
R
L
L
I
Y
N
R
P
P
G
E
V
S
K
S
R
Q
T
K
A
D
I
E
D
W
M
L
S
Q
N
PP
C
G
R
-
D
T
V
V
-
I
A
L
G
G
G
V
I
G
D
L
T
G
F
V
A
S
T
Y
M
R
G
V
R
Y
V
Q
V
P
T
T
L
L
A
M
V
D
S
S
I
G
G
K
T
A
I
D
T
P
L
G
K
N
L
I
G
A
I
W
Q
P
T
K
I
Y
I
D
L
E
F
L
E
T
L
P
V
R
E
F
I
N
G
M
A
E
V
I
K
T
A
A
I
------
S
S
E
E
E
F
------------
T
A
-
L
E
E
N
A
E
--
T
---------------
I
L
--------
K
A
V
R
R
E
-
V
--------RFEGT
E
E
I
L
K
A
R
I
L
A
S
A
R
H
K
A
Y
V
V
S
A
D
E
R
E
G
G
L
R
N
L
L
N
W
G
H
S
I
G
H
A
I
E
A
I
L
-
T
-
P
Q
I
L
H
G
E
C
V
A
I
G
M
V
K
E
A
E
L
A
R
H
L
G
I
L
K
G
V
A
V
S
R
I
V
K
C
L
A
A
Y
G
L
P
T
-
S
L
-
K
-
D
A
R
I
R
K
L
T
A
G
K
H
C
-----------
S
V
D
Q
-----------
L
M
-
F
N
M
A
L
D
K
K
N
D
-----
G
P
K
K
K
I
V
L
L
S
A
-
I
G
T
---------------------------------
13
PsiBlast_PDB
63.48
35%
2
- C3 -
-
1NVF
3
ARO1_EMENI
A:
[40-373]
-------------------------------------------
V
L
V
T
D
T
N
I
G
S
I
Y
T
P
S
F
--
E
--
E
A
F
-
R
K
R
A
A
------
E
I
T
P
S
P
R
L
L
I
Y
N
R
P
P
G
E
V
S
K
S
R
Q
T
K
A
D
I
E
D
W
M
L
S
Q
N
PP
C
G
R
-
D
T
V
V
-
I
A
L
G
G
G
V
I
G
D
L
T
G
F
V
A
S
T
Y
M
R
G
V
R
Y
V
Q
V
P
T
T
L
L
A
M
V
D
S
S
I
G
G
K
T
A
I
D
T
P
L
G
K
N
L
I
G
A
I
W
Q
P
T
K
I
Y
I
D
L
E
F
L
E
T
L
P
V
R
E
F
I
N
G
M
A
E
V
I
K
T
A
A
I
------
S
S
E
E
E
F
------------
T
A
-
L
E
E
N
A
E
--
T
---------------
I
L
--------
K
A
V
R
R
E
-
V
TPG
E
---
H
RFEGT
E
E
I
L
K
A
R
I
L
A
S
A
R
H
K
A
Y
V
V
S
A
D
E
R
E
G
G
L
R
N
L
L
N
W
G
H
S
I
G
H
A
I
E
A
I
L
-
T
-
P
Q
I
L
H
G
E
C
V
A
I
G
M
V
K
E
A
E
L
A
R
H
L
G
I
L
K
G
V
A
V
S
R
I
V
K
C
L
A
A
Y
G
L
P
T
-
S
L
-
K
-
D
A
R
I
R
K
L
T
A
G
K
H
C
-----------
S
V
D
Q
-----------
L
M
-
F
N
M
A
L
D
K
K
N
D
-----
G
P
K
K
K
I
V
L
L
S
A
-
I
G
T
---------------------------------
36
PsiBlast_CBE
61.77
35%
17
- C3 -
-
1DQS
3
ARO1_EMENI
B:
[40-373]
-------------------------------------------
V
L
V
T
D
T
N
I
G
S
I
Y
T
P
S
F
--
E
--
E
A
F
-
R
K
R
A
A
------
E
I
T
P
S
P
R
L
L
I
Y
N
R
P
P
G
E
V
S
K
S
R
Q
T
K
A
D
I
E
D
W
M
L
S
Q
N
PP
C
G
R
-
D
T
V
V
-
I
A
L
G
G
G
V
I
G
D
L
T
G
F
V
A
S
T
Y
M
R
G
V
R
Y
V
Q
V
P
T
T
L
L
A
M
V
D
S
S
I
G
G
K
T
A
I
D
T
P
L
G
K
N
L
I
G
A
I
W
Q
P
T
K
I
Y
I
D
L
E
F
L
E
T
L
P
V
R
E
F
I
N
G
M
A
E
V
I
K
T
A
A
I
------
S
S
E
E
E
F
------------
T
A
-
L
E
E
N
A
E
--
T
---------------
I
L
--------
K
A
V
R
R
-----------T
E
E
I
L
K
A
R
I
L
A
----
S
A
R
H
K
A
Y
V
V
S
A
D
E
R
E
G
G
L
R
N
L
L
N
W
G
H
S
I
G
H
A
I
E
A
I
L
-
T
-
P
Q
I
L
H
G
E
C
V
A
I
G
M
V
K
E
A
E
L
A
R
H
L
G
I
L
K
G
V
A
V
S
R
I
V
K
C
L
A
A
Y
G
L
P
T
-
S
L
-
K
-
D
A
R
I
R
K
L
T
AG
K
H
C
-----------
S
V
D
Q
-----------
L
M
-
F
N
M
A
L
D
K
K
N
D
-----
G
P
K
K
K
I
V
L
L
S
A
-
I
G
T
---------------------------------
8
PsiBlast_PDB
61.11
35%
-4
- C3 -
-
1NRX
1
ARO1_EMENI
A:
[40-373]
-------------------------------------------
V
L
V
T
D
T
N
I
G
S
I
Y
T
P
S
F
--
E
--
E
A
F
-
R
K
R
A
A
------
E
I
T
P
S
P
R
L
L
I
Y
N
R
P
P
G
E
V
S
K
S
R
Q
T
K
A
D
I
E
D
W
M
L
S
Q
N
PP
C
G
R
-
D
T
V
V
-
I
A
L
G
G
G
V
I
G
D
L
T
G
F
V
A
S
T
Y
M
R
G
V
R
Y
V
Q
V
P
T
T
L
L
A
M
V
D
S
S
I
G
G
K
T
A
I
D
T
P
L
G
K
N
L
I
G
A
I
W
Q
P
T
K
I
Y
I
D
L
E
F
L
E
T
L
P
V
R
E
F
I
N
G
M
A
E
V
I
K
T
A
A
I
------
S
S
E
E
E
F
------------
T
A
-
L
E
E
N
A
E
--
T
---------------
I
L
--------
K
A
V
R
R
E
-
V
TPG----
H
RFEGT
E
E
I
L
K
A
R
I
L
A
S
A
R
H
K
A
Y
V
V
S
A
D
---
G
G
L
R
N
L
L
N
W
G
H
S
I
G
H
A
I
E
A
I
L
-
T
-
P
Q
I
L
H
G
E
C
V
A
I
G
M
V
K
E
A
E
L
A
R
H
L
G
I
L
K
G
V
A
V
S
R
I
V
K
C
L
A
A
Y
G
L
P
T
-
S
L
-
K
-
D
A
R
I
R
K
L
T
AG
K
H
C
-----------
S
V
D
Q
-----------
L
M
-
F
N
M
A
L
D
----------
P
K
K
K
I
V
L
L
S
A
-
I
G
T
---------------------------------
34
PsiBlast_CBE
60.95
35%
-8
- C3 -
-
1NRX
1
ARO1_EMENI
B:
[40-373]
-------------------------------------------
V
L
V
T
D
T
N
I
G
S
I
Y
T
P
S
F
--
E
--
E
A
F
-
R
K
R
A
A
------
E
I
T
P
S
P
R
L
L
I
Y
N
R
P
P
G
E
V
S
K
S
R
Q
T
K
A
D
I
E
D
W
M
L
S
Q
N
PP
C
G
R
-
D
T
V
V
-
I
A
L
G
G
G
V
I
G
D
L
T
G
F
V
A
S
T
Y
M
R
G
V
R
Y
V
Q
V
P
T
T
L
L
A
M
V
D
S
S
I
G
G
K
T
A
I
D
T
P
L
G
K
N
L
I
G
A
I
W
Q
P
T
K
I
Y
I
D
L
E
F
L
E
T
L
P
V
R
E
F
I
N
G
M
A
E
V
I
K
T
A
A
I
------
S
S
E
E
E
F
------------
T
A
-
L
E
E
N
A
E
--
T
---------------
I
L
--------
K
A
V
R
R
E
-
V
T
PG
E
---
H
RFEGT
E
E
I
L
K
A
R
I
L
A
S
A
R
H
K
A
Y
V
V
S
A
D
---
G
G
L
R
N
L
L
N
W
G
H
S
I
G
H
A
I
E
A
I
L
-
T
-
P
Q
I
L
H
G
E
C
V
A
I
G
M
V
K
E
A
E
L
A
R
H
L
G
I
L
K
G
V
A
V
S
R
I
V
K
C
L
A
A
Y
G
L
P
T
-
S
L
-
K
-
D
A
R
I
R
K
L
T
AG
K
H
C
-----------
S
V
D
Q
-----------
L
M
-
F
N
M
A
L
D
----------
P
K
K
K
I
V
L
L
S
A
-
I
G
T
---------------------------------
30
PsiBlast_CBE
60.43
35%
0
- C3 -
-
1NVD
2
ARO1_EMENI
B:
[40-373]
-------------------------------------------
V
L
V
T
D
T
N
I
G
S
I
Y
T
P
S
F
--
E
--
E
A
F
-
R
K
R
A
A
------
E
I
T
P
S
P
R
L
L
I
Y
N
R
P
P
G
E
V
S
K
S
R
Q
T
K
A
D
I
E
D
W
M
L
S
Q
N
PP
C
G
R
-
D
T
V
V
-
I
A
L
G
G
G
V
I
G
D
L
T
G
F
V
A
S
T
Y
M
R
G
V
R
Y
V
Q
V
P
T
T
L
L
A
M
V
D
S
S
I
G
G
K
T
A
I
D
T
P
L
G
K
N
L
I
G
A
I
W
Q
P
T
K
I
Y
I
D
L
E
F
L
E
T
L
P
V
R
E
F
I
N
G
M
A
E
V
I
K
T
A
A
I
------
S
S
E
E
E
F
------------
T
A
-
L
E
E
N
A
E
--
T
---------------
I
L
--------
K
A
V
R
------------RFEGT
E
E
I
L
K
A
R
I
L
A
S
A
R
H
K
A
Y
V
V
S
A
D
E
R
E
G
G
L
R
N
L
L
N
W
G
H
S
I
G
H
A
I
E
A
I
L
-
T
-
P
Q
I
L
H
G
E
C
V
A
I
G
M
V
K
E
A
E
L
A
R
H
L
G
I
L
K
G
V
A
V
S
R
I
V
K
C
L
A
A
Y
G
L
P
T
-
S
L
-
K
-
D
A
R
I
R
K
L
T
AG
K
H
C
-----------
S
V
D
Q
-----------
L
M
-
F
N
M
A
L
D
K
K
N
D
-----
G
P
K
K
K
I
V
L
L
S
A
-
I
G
T
---------------------------------