@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : spr1246: (2018-01-08 )
MKKPIIEFKNVSKVFEDSNTKVLKDINFELEEGKFYTLLGASGSGKSTILNIIAGLLDATTGDIMLDGVRINDIPTNKRDVHTVFQSYALFPHMNVFENVAFPLRLRKIDKKEIEQRVAEVLKMVQLEGYEKRSIRKLSGGQRQRVAIARAIINQPRVVLLDEPLSALDLKLRTDMQYELRELQQRLGITFVFVTHDQEEALAMSDWIFVMNDGEIVQSGTPVDIYDEPINHFVATFIGESNILPGTMIEDYLVEFNGKRFEAVDGGMKPNEPVEVVIRPEDLRITLPEEGKLQVKVDTQLFRGVHYEIIAYDELGNEWMIHSTRKAIVGEEIGLDFEPEDIHIMRLNETEEEFDARIEEYVEIEEQEAGLINAIEEERDEENKL
Atome Classification :
(47 SA)
.....-....10.....--.-..---20........30........40........50........60-.......--.70----..------.------...-----..80...--------...--...90........100-.....---..110....--...120....-----..-.-130.......140.......150.......160.......---170.......180.......190.......200.......210.......220.......230.......--240-....----....250.--.--..-.-------..260--.-------...-----.-....270.......280.------......------290........300.......310.......-320----.--......-------------330.......340.......350.......360.......370.......380...
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MKKP
I
-
I
E
F
K
N
V
S
K
V
FE--D-SN---
T
K
V
L
K
DIN
F
E
LEE
G
K
F
Y
T
L
L
GASGSG
K
S
T
I
L
N
I
I
A
G
L
L
DATT-G
D
I
M
L
D
G
--
V
R
I----ND------I------PTN-----
K
R
D
-
V
H
T
--------
V
F
Q
--
S
YALFPH
M
N
V
F
E
NVAF-
P
L
R
L
R---KI
D
K
K
E
I
E
Q
--
R
V
A
E
V
L
K
M
V
Q
-----LE-G-Y
E
K
R
S
I
R
KLSGGQ
R
Q
R
V
A
I
A
R
A
I
INQP
R
V
V
L
LDEPLSAL
D
---
L
K
LRT
D
M
Q
Y
E
L
R
E
L
Q
Q
RL
G
I
T
F
V
F
V
THDQEEALAMS
D
W
I
F
V
MND
G
E
I
VQSGTPVDI
Y
D
E
P
I
N
H
F
V
A
T
F
IG--ES--NIL
P
----
G
T
M
I
E
D
Y
L
--
V
--EF-N-------G
K
R
----
F
-------
E
AV-----D-GGMKPNE
P
V
E
V
V
I
RPE
D
L
------
R
I
TLPE------E
G
-
K
L
Q
V
K
V
D
T
Q
L
FRG
V
H
Y
E
I
I
A
Y
DELGN
E
W
-
M
I
H
----
S
--
T
R
K
A
I
V-------------GEEIGLDFEPE
D
I
H
I
M
RLNE
T
E
E
E
F
D
A
R
I
E
E
Y
V
E
I
E
E
QEA
G
L
I
N
A
I
E
E
E
RDEENKL
131
Fugue
83.49
37%
-112
- C2 -
-
1Z47
-
?
A:
[11-355]
-
G
S
M
T
-
I
E
F
V
G
V
E
K
I
Y
---
P
-
G
G
---
A
R
S
V
R
G
V
S
F
Q
I
R
E
G
E
M
V
G
L
L
G
P
S
G
S
G
K
T
T
I
L
R
L
I
A
G
L
E
R
P
T
K
-
G
D
V
W
I
G
G
--
K
R
V
----
T
D
------
L
------
P
P
Q
-----
K
R
N
-
V
G
L
--------
V
F
Q
--
N
Y
A
L
F
Q
H
M
T
V
Y
D
N
V
S
F
-
G
L
R
E
K
---
R
V
P
K
D
E
M
D
A
--
R
V
R
E
L
L
R
F
M
R
-----
L
E
-
S
-
Y
A
N
R
F
P
H
E
L
S
G
G
Q
Q
Q
R
V
A
L
A
R
A
L
A
P
R
P
Q
V
L
L
F
D
E
P
F
A
A
I
D
---
T
Q
I
R
R
E
L
R
T
F
V
R
Q
V
H
D
E
M
G
V
T
S
V
F
V
T
H
D
Q
E
E
A
L
E
V
A
D
R
V
L
V
L
H
E
G
N
V
E
Q
F
G
T
P
E
E
V
Y
E
K
P
G
T
L
F
V
A
S
F
I
G
--
E
S
--
N
V
W
T
----
R
A
-
V
Q
N
G
R
--
I
--
E
V
-
A
-------
G
A
A
----
L
-------
P
-
V
-----
D
-
P
A
V
S
E
G
S
E
V
A
V
V
V
R
P
K
D
V
------
E
L
Q
P
A
S
------
E
R
-
E
A
H
A
Q
V
V
R
S
A
F
K
G
S
Y
S
A
C
W
I
R
T
K
D
G
E
V
W
-
E
V
H
V
P
--
S
--
A
D
R
H
R
W
-------------
S
P
G
A
W
V
H
M
N
V
T
R
W
F
I
F
P
R
--------------------------------------
19
PsiBlast_PDB
80.19
38%
-104
- C2 -
-
3PUV
2
MALK_ECOLI
A:
[4-360]
------
V
Q
L
Q
N
V
T
K
A
W
G
--
E
------
V
V
V
S
K
D
I
N
L
D
I
H
E
G
E
F
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
I
A
G
L
E
T
I
T
S
-
G
D
L
F
I
G
E
--
K
R
M
----
N
D
------
T
------
P
P
A
-----
E
R
G
-
V
G
M
--------
V
F
Q
--
S
Y
A
L
Y
P
H
L
S
V
A
E
N
M
S
F
-
G
L
K
L
A
---
G
A
K
K
E
V
I
N
Q
--
R
V
N
Q
V
A
E
V
L
Q
-----
L
A
-
H
-
L
L
D
R
K
P
K
A
L
S
G
G
Q
R
Q
R
V
A
I
G
R
T
L
V
A
E
P
S
V
F
L
L
D
E
P
L
S
N
L
D
---
A
A
L
R
V
Q
M
R
I
E
I
S
R
L
H
K
R
L
G
R
T
M
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
K
I
V
V
L
D
A
G
R
V
A
Q
V
G
K
P
L
E
L
Y
H
Y
P
A
D
R
F
V
A
G
F
I
G
--
S
P
K
M
N
F
L
P
V
K
V
T
A
T
A
I
D
Q
V
Q
--
V
--
E
L
-
P
-------
M
P
N
----
R
-------
Q
Q
V
W
L
PVE
S
-
R
D
V
Q
V
G
A
N
M
S
L
G
I
R
P
E
H
L
---------
L
P
S
------
D
-------
I
A
D
V
I
L
E
G
---
E
V
Q
V
V
E
Q
L
G
N
E
T
-
Q
I
H
I
Q
I
P
S
--
I
R
Q
N
L
V
Y
R
Q
N
D
V
V
L
V
E
E--
G
A
T
F
A
I
G
L
P
P
E
R
C
H
L
F
R
E
D
G
T
-----------------------------------
2
PsiBlast_PDB
80.00
40%
-123
- C2 -
-
1Z47
-
?
A:
[15-328]
------
I
E
F
V
G
V
E
K
I
Y
---
P
-
G
G
---
A
R
S
V
R
G
V
S
F
Q
I
R
E
G
E
M
V
G
L
L
G
P
S
G
S
G
K
T
T
I
L
R
L
I
A
G
L
E
R
P
T
K
-
G
D
V
W
I
G
G
--
K
R
V
----
T
D
------
L
------
P
P
Q
-----
K
R
N
-
V
G
L
--------
V
F
Q
--
N
Y
A
L
F
Q
H
M
T
V
Y
D
N
V
S
F
-
G
L
R
E
K
---
R
V
P
K
D
E
M
D
A
--
R
V
R
E
L
L
R
F
M
R
-----
L
E
-
S
-
Y
A
N
R
F
P
H
E
L
S
G
G
Q
Q
Q
R
V
A
L
A
R
A
L
A
P
R
P
Q
V
L
L
F
D
E
P
F
A
A
I
D
---
T
Q
I
R
R
E
L
R
T
F
V
R
Q
V
H
D
E
M
G
V
T
S
V
F
V
T
H
D
Q
E
E
A
L
E
V
A
D
R
V
L
V
L
H
E
G
N
V
E
Q
F
G
T
P
E
E
V
Y
E
K
P
G
T
L
F
V
A
S
F
I
G
--
E
S
--
N
V
W
T
-----
R
A
V
Q
N
G
R
--
I
--
E
V
-
A
-------
G
A
A
----
L
--------
P
V
-----
D
-
P
A
V
S
E
G
S
E
V
A
V
V
V
R
P
K
D
V
------
E
L
Q
P
A
S
------
E
R
-
E
A
H
A
Q
V
V
R
S
A
F
K
G
S
Y
S
A
C
W
I
R
T
K
D
G
E
V
W
-
E
V
H
----------------------------------------------------------------------------------
16
PsiBlast_PDB
79.44
38%
-101
- C2 -
-
3PUY
2
MALK_ECOLI
A:
[4-360]
------
V
Q
L
Q
N
V
T
K
A
W
G
--
E
------
V
V
V
S
K
D
I
N
L
D
I
H
E
G
E
F
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
I
A
G
L
E
T
I
T
S
-
G
D
L
F
I
G
E
--
K
R
M
----
N
D
------
T
------
P
P
A
-----
E
R
G
-
V
G
M
--------
V
F
Q
--
S
Y
A
L
Y
P
H
L
S
V
A
E
N
M
S
F
-
G
L
K
L
A
---
G
A
K
K
E
V
I
N
Q
--
R
V
N
Q
V
A
E
V
L
Q
-----
L
A
-
H
-
L
L
D
R
K
P
K
A
L
S
G
G
Q
R
Q
R
V
A
I
G
R
T
L
V
A
E
P
S
V
F
L
L
D
E
P
L
S
N
L
D
---
A
A
L
R
V
Q
M
R
I
E
I
S
R
L
H
K
R
L
G
R
T
M
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
K
I
V
V
L
D
A
G
R
V
A
Q
V
G
K
P
L
E
L
Y
H
Y
P
A
D
R
F
V
A
G
F
I
G
--
S
P
K
M
N
F
L
P
V
K
V
T
A
T
A
I
D
Q
V
Q
--
V
--
E
L
-
P
-------
M
P
N
----
R
-------
Q
Q
V
W
L
PVE
S
-
R
D
V
Q
V
G
A
N
M
S
L
G
I
R
P
E
H
L
---------
L
P
S
------
D
-------
I
A
D
V
I
L
E
G
---
E
V
Q
V
V
E
Q
L
G
N
E
T
-
Q
I
H
I
Q
I
P
S
--
I
R
Q
N
L
V
Y
R
Q
N
D
V
V
L
V
E
E--
G
A
T
F
A
I
G
L
P
P
E
R
C
H
L
F
R
E
D
G
T
-----------------------------------
20
PsiBlast_PDB
79.31
38%
-99
- C2 -
-
3PUW
2
MALK_ECOLI
A:
[4-360]
------
V
Q
L
Q
N
V
T
K
A
W
G
--
E
------
V
V
V
S
K
D
I
N
L
D
I
H
E
G
E
F
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
I
A
G
L
E
T
I
T
S
-
G
D
L
F
I
G
E
--
K
R
M
----
N
D
------
T
------
P
P
A
-----
E
R
G
-
V
G
M
--------
V
F
Q
--
S
Y
A
L
Y
P
H
L
S
V
A
E
N
M
S
F
-
G
L
K
L
A
---
G
A
K
K
E
V
I
N
Q
--
R
V
N
Q
V
A
E
V
L
Q
-----
L
A
-
H
-
L
L
D
R
K
P
K
A
L
S
G
G
Q
R
Q
R
V
A
I
G
R
T
L
V
A
E
P
S
V
F
L
L
D
E
P
L
S
N
L
D
---
A
A
L
R
V
Q
M
R
I
E
I
S
R
L
H
K
R
L
G
R
T
M
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
K
I
V
V
L
D
A
G
R
V
A
Q
V
G
K
P
L
E
L
Y
H
Y
P
A
D
R
F
V
A
G
F
I
G
--
S
P
K
M
N
F
L
P
V
K
V
T
A
T
A
I
D
Q
V
Q
--
V
--
E
L
-
P
-------
M
P
N
----
R
-------
Q
Q
V
W
L
PVE
S
-
R
D
V
Q
V
G
A
N
M
S
L
G
I
R
P
E
H
L
---------
L
P
S
------
D
-------
I
A
D
V
I
L
E
G
---
E
V
Q
V
V
E
Q
L
G
N
E
T
-
Q
I
H
I
Q
I
P
S
--
I
R
Q
N
L
V
Y
R
Q
N
D
V
V
L
V
E
E--
G
A
T
F
A
I
G
L
P
P
E
R
C
H
L
F
R
E
D
G
T
-----------------------------------
27
PsiBlast_CBE
79.15
38%
-103
- C2 -
-
3PUZ
1
MALK_ECOLI
B:
[4-360]
------
V
Q
L
Q
N
V
T
K
A
W
G
--
E
------
V
V
V
S
K
D
I
N
L
D
I
H
E
G
E
F
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
I
A
G
L
E
T
I
T
S
-
G
D
L
F
I
G
E
--
K
R
M
----
N
D
------
T
------
P
P
A
-----
E
R
G
-
V
G
M
--------
V
F
Q
--
S
Y
A
L
Y
P
H
L
S
V
A
E
N
M
S
F
-
G
L
K
L
A
---
G
A
K
K
E
V
I
N
Q
--
R
V
N
Q
V
A
E
V
L
Q
-----
L
A
-
H
-
L
L
D
R
K
P
K
A
L
S
G
G
Q
R
Q
R
V
A
I
G
R
T
L
V
A
E
P
S
V
F
L
L
D
E
P
L
S
N
L
D
---
A
A
L
R
V
Q
M
R
I
E
I
S
R
L
H
K
R
L
G
R
T
M
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
K
I
V
V
L
D
A
G
R
V
A
Q
V
G
K
P
L
E
L
Y
H
Y
P
A
D
R
F
V
A
G
F
I
G
--
S
P
KM
N
F
L
P
VKVT
A
T
A
I
D
Q
V
Q
--
V
--
E
L
-
P
-------
M
P
N
----
R
-------
Q
Q
V
WLPVE
S
-
R
D
V
Q
V
G
A
N
M
S
L
G
I
R
P
E
H
L
---------
L
P
S
------
D
-------
I
A
D
V
I
L
E
G
---
E
V
Q
V
V
E
Q
L
G
N
E
T
-
Q
I
H
IQIP
S
--
I
R
Q
N
L
V
YRQNDVVLVEE--
G
A
T
F
A
I
G
L
P
P
E
R
C
H
L
F
R
E
D
G
T
-----------------------------------
28
PsiBlast_CBE
79.11
38%
-96
- C2 -
-
3PUX
2
MALK_ECOLI
A:
[4-360]
------
V
Q
L
Q
N
V
T
K
A
W
G
--
E
------
V
V
V
S
K
D
I
N
L
D
I
H
E
G
E
F
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
I
A
G
L
E
T
I
T
S
-
G
D
L
F
I
G
E
--
K
R
M
----
N
D
------
T
------
P
P
A
-----
E
R
G
-
V
G
M
--------
V
F
Q
--
S
Y
A
L
Y
P
H
L
S
V
A
E
N
M
S
F
-
G
L
K
L
A
---
G
A
K
K
E
V
I
N
Q
--
R
V
N
Q
V
A
E
V
L
Q
-----
L
A
-
H
-
L
L
D
R
K
P
K
A
L
S
G
G
Q
R
Q
R
V
A
I
G
R
T
L
V
A
E
P
S
V
F
L
L
D
E
P
L
S
N
L
D
---
A
A
L
R
V
Q
M
R
I
E
I
S
R
L
H
K
R
L
G
R
T
M
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
K
I
V
V
L
D
A
G
R
V
A
Q
V
G
K
P
L
E
L
Y
H
Y
P
A
D
R
F
V
A
G
F
I
G
--
S
P
K
M
N
F
L
P
V
K
V
T
A
T
A
I
D
Q
V
Q
--
V
--
E
L
-
P
-------
M
P
N
----
R
-------
Q
Q
V
W
L
PVE
S
-
R
D
V
Q
V
G
A
N
M
S
L
G
I
R
P
E
H
L
---------
L
P
S
------
D
-------
I
A
D
V
I
L
E
G
---
E
V
Q
V
V
E
Q
L
G
N
E
T
-
Q
I
H
I
Q
I
P
S
--
I
R
Q
N
L
V
Y
R
Q
N
D
V
V
L
V
E
E
--
G
A
T
F
A
I
G
L
P
P
E
R
C
H
L
F
R
E
D
G
T
-----------------------------------
139
HHSearch
79.02
38%
-94
- C2 -
-
4TQU
-
?
T:
[3-360]
---
A
S
-
V
S
I
Q
N
V
V
K
R
Y
D
--
K
------
T
T
V
V
H
G
V
S
L
D
I
E
P
G
E
F
V
V
L
V
G
P
S
G
C
G
K
S
T
T
L
R
M
V
A
G
L
E
E
I
S
G
-
G
T
I
R
I
D
G
--
R
V
I
----
N
D
------
L
------
A
P
K
-----
D
R
D
-
V
A
M
--------
V
F
Q
--
N
Y
A
L
Y
P
H
L
N
V
R
D
N
I
S
F
-
G
L
R
L
K
---
R
T
K
K
S
V
I
D
A
--
A
V
K
T
A
A
D
I
L
G
-----
L
Q
-
P
-
L
L
E
R
K
P
S
D
L
S
G
G
Q
R
Q
R
V
A
M
G
R
A
I
V
R
D
P
K
V
F
L
F
D
Q
P
L
S
N
L
D
---
A
K
L
R
T
Q
M
R
A
E
I
K
R
L
H
Q
R
L
G
T
T
V
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
R
I
V
V
M
R
D
G
L
I
E
Q
I
G
K
P
M
D
L
F
L
H
P
A
N
T
F
V
A
S
F
I
G
--
S
P
PM
N
L
M
P
----
A
R
I
A
V
D
S
T
--
Q
HV
E
L
N
G
-------
G
N
R
----
I
-------
S
L
L
PR---
A
G
T
H
L
A
P
G
Q
E
V
V
F
G
I
R
P
E
D
V
------
T
L
D
G
V
E
GSE---
R
A
-
Q
I
K
A
T
V
D
I
V
E
P
L
G
S
E
S
I
L
H
A
-
T
V
G
D
H
S
L
-
V
V
K
VG--
G
--
L
N
E
V
H
P
-------------
G
D
P
V
T
L
H
V
D
L
T
R
V
H
L
F
D
A
Q
S
Q
A
----------------------------------
24
PsiBlast_CBE
78.99
38%
-97
- C2 -
-
4KI0
3
MALK_ECOLI
A:
[4-360]
------
V
Q
L
Q
N
V
T
K
A
W
G
--
E
------
V
V
V
S
K
D
I
N
L
D
I
H
E
G
E
F
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
I
A
G
L
E
T
I
T
S
-
G
D
L
F
I
G
E
--
K
R
M
----
N
D
------
T
------
P
P
A
-----
E
R
G
-
V
G
M
--------
V
F
Q
--
S
Y
A
L
Y
P
H
L
S
V
A
E
N
M
S
F
-
G
L
K
L
A
---
G
A
K
K
E
V
I
N
Q
--
R
V
N
Q
V
A
E
V
L
Q
-----
L
A
-
H
-
L
L
D
R
K
P
K
A
L
S
G
G
Q
R
Q
R
V
A
I
G
R
T
L
V
A
E
P
S
V
F
L
L
D
E
P
L
S
N
L
D
---
A
A
L
R
V
Q
M
R
I
E
I
S
R
L
H
K
R
L
G
R
T
M
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
K
I
V
V
L
D
A
G
R
V
A
Q
V
G
K
P
L
E
L
Y
H
Y
P
A
D
R
F
V
A
G
F
I
G
--
S
P
K
M
N
F
L
P
V
K
V
T
A
T
A
I
D
Q
V
Q
--
V
--
E
L
-
P
-------
M
P
N
----
R
-------
Q
Q
V
W
L
PVE
S
-
R
D
V
Q
V
G
A
N
M
S
L
G
I
R
P
E
H
L
---------
L
P
S
------
D
-------
I
A
D
V
I
L
E
G
---
E
V
Q
V
V
E
Q
L
G
N
E
T
-
Q
I
H
I
Q
I
P
S
--
I
R
Q
N
L
V
Y
R
Q
N
D
V
V
L
V
E
E
--
G
A
T
F
A
I
G
L
P
P
E
R
C
H
L
F
R
E
D
G
T
-----------------------------------
26
PsiBlast_CBE
78.94
38%
-100
- C2 -
-
3RLF
2
MALK_ECOLI
A:
[4-360]
------
V
Q
L
Q
N
V
T
K
A
W
G
--
E
------
V
V
V
S
K
D
I
N
L
D
I
H
E
G
E
F
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
I
A
G
L
E
T
I
T
S
-
G
D
L
F
I
G
E
--
K
R
M
----
N
D
------
T
------
P
P
A
-----
E
R
G
-
V
G
M
--------
V
F
Q
--
S
Y
A
L
Y
P
H
L
S
V
A
E
N
M
S
F
-
G
L
K
L
A
---
G
A
K
K
E
V
I
N
Q
--
R
V
N
Q
V
A
E
V
L
Q
-----
L
A
-
H
-
L
L
D
R
K
P
K
A
L
S
G
G
Q
R
Q
R
V
A
I
G
R
T
L
V
A
E
P
S
V
F
L
L
D
E
P
L
S
N
L
D
---
A
A
L
R
V
Q
M
R
I
E
I
S
R
L
H
K
R
L
G
R
T
M
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
K
I
V
V
L
D
A
G
R
V
A
Q
V
G
K
P
L
E
L
Y
H
Y
P
A
D
R
F
V
A
G
F
I
G
--
S
P
K
M
N
F
L
P
V
K
V
T
A
T
A
I
D
Q
V
Q
--
V
--
E
L
-
P
-------
M
P
N
----
R
-------
Q
Q
V
W
L
PVE
S
-
R
D
V
Q
V
G
A
N
M
S
L
G
I
R
P
E
H
L
---------
L
P
S
------
D
-------
I
A
D
V
I
L
E
G
---
E
V
Q
V
V
E
Q
L
G
N
E
T
-
Q
I
H
I
Q
I
P
S
--
I
R
Q
N
L
V
Y
R
Q
N
D
V
V
L
V
E
E--
G
A
T
F
A
I
G
L
P
P
E
R
C
H
L
F
R
E
D
G
T
-----------------------------------
38
PsiBlast_CBE
78.72
38%
-95
- C2 -
-
2R6G
2
MALK_ECOLI (first)
A:
[4-360]
------
V
Q
L
Q
N
V
T
K
A
W
G
--
E
------
V
V
V
S
K
D
I
N
L
D
I
H
E
G
E
F
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
I
A
G
L
E
T
I
T
S
-
G
D
L
F
I
G
E
--
K
R
M
----
N
D
------
T
------
P
P
A
-----
E
R
G
-
V
G
M
--------
V
F
Q
--
S
Y
A
L
Y
P
H
L
S
V
A
E
N
M
S
F
-
G
L
K
L
A
---
G
A
K
K
E
V
I
N
Q
--
R
V
N
Q
V
A
E
V
L
Q
-----
L
A
-
H
-
L
L
D
R
K
P
K
A
L
S
G
G
Q
R
Q
R
V
A
I
G
R
T
L
V
A
E
P
S
V
F
L
L
D
Q
P
L
S
N
L
D
---
A
A
L
R
V
Q
M
R
I
E
I
S
R
L
H
K
R
L
G
R
T
M
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
K
I
V
V
L
D
A
G
R
V
A
Q
V
G
K
P
L
E
L
Y
H
Y
P
A
D
R
F
V
A
G
F
I
G
--
S
P
K
M
N
F
L
P
V
K
V
T
A
T
A
I
D
Q
V
Q
--
V
--
E
L
-
P
-------
M
P
N
----
R
-------
Q
Q
V
W
L
PVE
S
-
R
D
V
Q
V
G
A
N
M
S
L
G
I
R
P
E
H
L
---------
L
P
S
------
D
-------
I
A
D
V
I
L
E
G
---
E
V
Q
V
V
E
Q
L
G
N
E
T
-
Q
I
H
I
QIP
S
--
I
R
Q
N
L
V
Y
R
Q
N
D
V
V
L
V
E
E--
G
A
T
F
A
I
G
L
P
P
E
R
C
H
L
F
R
E
D
G
T
-----------------------------------
8
PsiBlast_PDB
78.62
40%
-125
- C2 -
-
4XTC
-
?
S:
[5-327]
------
V
S
I
Q
N
V
V
K
R
Y
D
-----
K
---
T
T
V
V
H
G
V
S
L
D
I
E
P
G
E
F
V
V
L
V
G
P
S
G
C
G
K
S
T
T
L
R
M
V
A
G
L
E
E
I
S
G
-
G
T
I
R
I
D
G
--
R
V
I
----
N
D
------
L
------
A
P
K
-----
D
R
D
-
V
A
M
--------
V
F
Q
--
N
Y
A
L
Y
P
H
L
N
V
R
D
N
I
S
F
-
G
L
R
L
K
---
R
T
K
K
S
V
I
D
A
--
A
V
K
T
A
A
D
I
L
G
-----
L
Q
-
P
-
L
L
E
R
K
P
S
D
L
S
G
G
Q
R
Q
R
V
A
M
G
R
A
I
V
R
D
P
K
V
F
L
F
D
Q
P
L
S
N
L
D
---
A
K
L
R
T
Q
M
R
A
E
I
K
R
L
H
Q
R
L
G
T
T
V
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
R
I
V
V
M
R
D
G
L
I
E
Q
I
G
K
P
M
D
L
F
L
H
P
A
N
T
F
V
A
S
F
I
G
--
S
P
PM
N
L
M
P
----
A
R
I
A
V
D
S
T
QH
V
--
E
L
-
N
-------
G
G
N
RISL
L
-------
P
R
A
-----
G
-
T
H
L
A
P
G
Q
E
V
V
F
G
I
R
P
E
D
V
------
T
L
D
G
V
E
------
G
S
E
R
A
Q
I
K
A
T
V
D
I
V
E
P
L
G
S
E
S
I
L
H
A
T
V
G
D
H
S
-
L
V
-----------------------------------------------------------------------------------
146
HHSearch
78.42
37%
-105
- C2 -
-
1Z47
-
?
A:
[14-355]
----
T
-
I
E
F
V
G
V
E
K
I
Y
P
--
G
-
G
----
A
R
S
V
R
G
V
S
F
Q
I
R
E
G
E
M
V
G
L
L
G
P
S
G
S
G
K
T
T
I
L
R
L
I
A
G
L
E
R
P
T
K
-
G
D
V
W
I
G
G
--
K
R
V
----
T
D
------
L
------
P
P
Q
-----
K
R
N
-
V
G
L
--------
V
F
Q
--
N
Y
A
L
F
Q
H
M
T
V
Y
D
N
V
S
F
-
G
L
R
E
K
---
R
V
P
K
D
E
M
D
A
--
R
V
R
E
L
L
R
F
M
R
-----
L
E
-
S
-
Y
A
N
R
F
P
H
E
L
S
G
G
Q
Q
Q
R
V
A
L
A
R
A
L
A
P
R
P
Q
V
L
L
F
D
E
P
F
A
A
I
D
---
T
Q
I
R
R
E
L
R
T
F
V
R
Q
V
H
D
E
M
G
V
T
S
V
F
V
T
H
D
Q
E
E
A
L
E
V
A
D
R
V
L
V
L
H
E
G
N
V
E
Q
F
G
T
P
E
E
V
Y
E
K
P
G
T
L
F
V
A
S
F
I
G
--
E
S
--
N
V
W
T
----
R
A
V
Q
N
G
R
I
-----
E
V
-
A
-------
G
A
A
----
L
-------
P
V
------
D
-
P
A
V
S
E
G
S
E
V
A
V
V
V
R
P
K
D
V
------
E
L
Q
P
A
S
------
E
R
-
E
A
H
A
Q
V
V
R
S
A
F
K
G
S
Y
S
A
C
W
I
-
R
T
K
D
G
E
V
W
E
V
H
----
V
P
S
A
D
R
H
R
W
-------------
S
P
G
A
W
V
H
M
N
V
T
R
W
F
I
F
P
R
--------------------------------------
144
HHSearch
78.28
38%
-106
- C2 -
-
1Z47
-
?
B:
[14-355]
----
T
-
I
E
F
V
G
V
E
K
I
Y
P
--
G
-
G
----
A
R
S
V
R
G
V
S
F
Q
I
R
E
G
E
M
V
G
L
L
G
P
S
G
S
G
K
T
T
I
L
R
L
I
A
G
L
E
R
P
T
K
-
G
D
V
W
I
G
G
--
K
R
V
----
T
D
------
L
------
P
P
Q
-----
K
R
N
-
V
G
L
--------
V
F
Q
--
N
Y
A
L
F
Q
H
M
T
V
Y
D
N
V
S
F
-
G
L
R
E
K
---
R
V
P
K
D
E
M
D
A
--
R
V
R
E
L
L
R
F
M
R
-----
L
E
-
S
-
Y
A
N
R
F
P
H
E
L
S
G
G
Q
Q
Q
R
V
A
L
A
R
A
L
A
P
R
P
Q
V
L
L
F
D
E
P
F
A
A
I
D
---
T
Q
I
R
R
E
L
R
T
F
V
R
Q
V
H
D
E
M
G
V
T
S
V
F
V
T
H
D
Q
E
E
A
L
E
V
A
D
R
V
L
V
L
H
E
G
N
V
E
Q
F
G
T
P
E
E
V
Y
E
K
P
G
T
L
F
V
A
S
F
I
G
--
E
S
--
N
V
W
T
----
R
A
V
Q
N
G
R
I
-----
E
V
-
A
-------
G
A
A
----
L
-------
P
V
------
D
-
P
A
V
S
E
G
S
E
V
A
V
V
V
R
P
K
D
V
------
E
L
Q
P
A
S
------
E
R
-
E
A
H
A
Q
V
V
R
S
A
F
K
G
S
Y
S
A
C
W
I
-
R
T
K
D
G
E
V
W
E
V
H
V
P
--
S
--
A
D
R
H
R
W
-------------
S
P
G
A
W
V
H
M
N
V
T
R
W
F
I
F
P
R
--------------------------------------
25
PsiBlast_CBE
78.07
38%
-98
- C2 -
-
3RLF
2
MALK_ECOLI
B:
[4-360]
------
V
Q
L
Q
N
V
T
K
A
W
G
--
E
------
V
V
V
S
K
D
I
N
L
D
I
H
E
G
E
F
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
I
A
G
L
E
T
I
T
S
-
G
D
L
F
I
G
E
--
K
R
M
----
N
D
------
T
------
P
P
A
-----
E
R
G
-
V
G
M
--------
V
F
Q
--
S
Y
A
L
Y
P
H
L
S
V
A
E
N
M
S
F
-
G
L
K
L
A
---
G
A
K
K
E
V
I
N
Q
--
R
V
N
Q
V
A
E
V
L
Q
-----
L
A
-
H
-
L
L
D
R
K
P
K
A
L
S
G
G
Q
R
Q
R
V
A
I
G
R
T
L
V
A
E
P
S
V
F
L
L
D
E
P
L
S
N
L
D
---
A
A
L
R
V
Q
M
R
I
E
I
S
R
L
H
K
R
L
G
R
T
M
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
K
I
V
V
L
D
A
G
R
V
A
Q
V
G
K
P
L
E
L
Y
H
Y
P
A
D
R
F
V
A
G
F
I
G
--
S
P
KM
N
F
L
P
VKVT
A
T
A
I
D
Q
V
Q
--
V
--
E
L
-
P
-------
M
P
N
----
R
-------
Q
Q
V
WLPVE
S
-
R
D
V
Q
V
G
A
N
M
S
L
G
I
R
P
E
H
L
---------
L
P
S
------
D
-------
I
A
D
V
I
L
E
G
---
E
V
Q
V
V
E
Q
L
G
N
E
T
-
Q
I
H
IQIP
S
--
I
R
Q
N
L
V
YRQNDVVLVEE--
G
A
T
F
-
I
G
L
P
P
E
R
C
H
L
F
R
E
D
G
T
-----------------------------------
33
PsiBlast_CBE
77.98
38%
-98
- C2 -
-
2AWN
1
MALK_ECOLI
B:
[4-360]
------
V
Q
L
Q
N
V
T
K
A
W
G
--
E
------
V
V
V
S
K
D
I
N
L
D
I
H
E
G
E
F
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
I
A
G
L
E
T
I
T
S
-
G
D
L
F
I
G
E
--
K
R
M
----
N
D
------
T
------
P
P
A
-----
E
R
G
-
V
G
M
--------
V
F
Q
--
S
Y
A
L
Y
P
H
L
S
V
A
E
N
M
S
F
-
G
L
K
L
A
---
G
A
K
K
E
V
I
N
Q
--
R
V
N
Q
V
A
E
V
L
Q
-----
L
A
-
H
-
L
L
D
R
K
P
K
A
L
S
G
G
Q
R
Q
R
V
A
I
G
R
T
L
V
A
E
P
S
V
F
L
L
D
E
P
L
S
N
L
D
---
A
A
L
R
V
Q
M
R
I
E
I
S
R
L
H
K
R
L
G
R
T
M
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
K
I
V
V
L
D
A
G
R
V
A
Q
V
G
K
P
L
E
L
Y
H
Y
P
A
D
R
F
V
A
G
F
I
G
--
S
P
K
M
N
F
L
P
V
K
V
T
A
T
A
I
D
Q
V
Q
--
V
--
E
L
-
P
-------
M
P
N
----
R
-------
Q
Q
V
W
L
PVE
S
-
R
D
V
Q
V
G
A
N
M
S
L
G
I
R
P
E
H
L
---------
L
P
S
------
D
-------
I
A
D
V
I
L
E
G
---
E
V
Q
V
V
E
Q
L
G
N
E
T
-
Q
I
H
I
Q
I
P
S
--
I
R
Q
N
L
V
Y
R
Q
N
D
V
V
L
V
E
E--
G
A
T
F
A
I
G
L
P
P
E
R
C
H
L
F
R
E
D
G
T
-----------------------------------
17
PsiBlast_PDB
77.77
38%
-99
- C2 -
-
3PUZ
1
MALK_ECOLI
A:
[4-360]
------
V
Q
L
Q
N
V
T
K
A
W
G
--
E
------
V
V
V
S
K
D
I
N
L
D
I
H
E
G
E
F
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
I
A
G
L
E
T
I
T
S
-
G
D
L
F
I
G
E
--
K
R
M
----
N
D
------
T
------
P
P
A
-----
E
R
G
-
V
G
M
--------
V
F
Q
--
S
Y
A
L
Y
P
H
L
S
V
A
E
N
M
S
F
-
G
L
K
L
A
---
G
A
K
K
E
V
I
N
Q
--
R
V
N
Q
V
A
E
V
L
Q
-----
L
A
-
H
-
L
L
D
R
K
P
K
A
L
S
G
G
Q
R
Q
R
V
A
I
G
R
T
L
V
A
E
P
S
V
F
L
L
D
E
P
L
S
N
L
D
---
A
A
L
R
V
Q
M
R
I
E
I
S
R
L
H
K
R
L
G
R
T
M
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
K
I
V
V
L
D
A
G
R
V
A
Q
V
G
K
P
L
E
L
Y
H
Y
P
A
D
R
F
V
A
G
F
I
G
--
S
P
K
M
N
F
L
P
V
K
V
T
A
T
A
I
D
Q
V
Q
--
V
--
E
L
-
P
-------
M
P
N
----
R
-------
Q
Q
V
W
L
PVE
S
-
R
D
V
Q
V
G
A
N
M
S
L
G
I
R
P
E
H
L
---------
L
P
S
------
D
-------
I
A
D
V
I
L
E
G
---
E
V
Q
V
V
E
Q
L
G
N
E
T
-
Q
I
H
I
Q
I
P
S
--
I
R
Q
N
L
V
Y
R
Q
N
D
V
V
L
V
E
E
--
G
A
T
F
A
I
G
L
P
P
E
R
C
H
L
F
R
E
D
G
T
-----------------------------------
37
PsiBlast_CBE
77.51
38%
-99
- C2 -
-
2R6G
2
MALK_ECOLI (first)
B:
[4-360]
------
V
Q
L
Q
N
V
T
K
A
W
G
--
E
------
V
V
V
S
K
D
I
N
L
D
I
H
E
G
E
F
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
I
A
G
L
E
T
I
T
S
-
G
D
L
F
I
G
E
--
K
R
M
----
N
D
------
T
------
P
P
A
-----
E
R
G
-
V
G
M
--------
V
F
Q
--
S
Y
A
L
Y
P
H
L
S
V
A
E
N
M
S
F
-
G
L
K
L
A
---
G
A
K
K
E
V
I
N
Q
--
R
V
N
Q
V
A
E
V
L
Q
-----
L
A
-
H
-
L
L
D
R
K
P
K
A
L
S
G
G
Q
R
Q
R
V
A
I
G
R
T
L
V
A
E
P
S
V
F
L
L
D
Q
P
L
S
N
L
D
---
A
A
L
R
V
Q
M
R
I
E
I
S
R
L
H
K
R
L
G
R
T
M
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
K
I
V
V
L
D
A
G
R
V
A
Q
V
G
K
P
L
E
L
Y
H
Y
P
A
D
R
F
V
A
G
F
I
G
--
S
P
KM
N
F
L
P
VKVT
A
T
A
I
D
Q
V
Q
--
V
--
E
L
-
P
-------
M
P
N
----
R
-------
Q
Q
V
WLPVE
S
-
R
D
V
Q
V
G
A
N
M
S
L
G
I
R
P
E
H
L
---------
L
P
S
------
D
-------
I
A
D
V
I
L
E
G
---
E
V
Q
V
V
E
Q
L
G
N
E
T
-
Q
I
H
IQIP
S
--
I
R
Q
N
L
V
YRQNDVVLVEE--
G
A
T
F
A
I
G
L
P
P
E
R
C
H
L
F
R
E
D
G
T
-----------------------------------
23
PsiBlast_CBE
77.51
38%
-96
- C2 -
-
4KI0
2
MALK_ECOLI
B:
[4-360]
------
V
Q
L
Q
N
V
T
K
A
W
G
--
E
------
V
V
V
S
K
D
I
N
L
D
I
H
E
G
E
F
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
I
A
G
L
E
T
I
T
S
-
G
D
L
F
I
G
E
--
K
R
M
----
N
D
------
T
------
P
P
A
-----
E
R
G
-
V
G
M
--------
V
F
Q
--
S
Y
A
L
Y
P
H
L
S
V
A
E
N
M
S
F
-
G
L
K
L
A
---
G
A
K
K
E
V
I
N
Q
--
R
V
N
Q
V
A
E
V
L
Q
-----
L
A
-
H
-
L
L
D
R
K
P
K
A
L
S
G
G
Q
R
Q
R
V
A
I
G
R
T
L
V
A
E
P
S
V
F
L
L
D
E
P
L
S
N
L
D
---
A
A
L
R
V
Q
M
R
I
E
I
S
R
L
H
K
R
L
G
R
T
M
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
K
I
V
V
L
D
A
G
R
V
A
Q
V
G
K
P
L
E
L
Y
H
Y
P
A
D
R
F
V
A
G
F
I
G
--
S
P
KM
N
F
L
P
VKVT
A
T
A
I
D
Q
V
Q
--
V
--
E
L
-
P
-------
M
P
N
----
R
-------
Q
Q
V
WLPVE
S
-
R
D
V
Q
V
G
A
N
M
S
L
G
I
R
P
E
H
L
---------
L
P
S
------
D
-------
I
A
D
V
I
L
E
G
---
E
V
Q
V
V
E
Q
L
G
N
E
T
-
Q
I
H
IQIP
S
--
I
R
Q
N
L
V
YRQNDVVLVEE--
G
A
T
F
A
I
G
L
P
P
E
R
C
H
L
F
R
E
D
G
T
-----------------------------------
31
PsiBlast_CBE
76.67
38%
-95
- C2 -
-
2AWO
1
MALK_ECOLI
B:
[4-360]
------
V
Q
L
Q
N
V
T
K
A
W
G
--
E
------
V
V
V
S
K
D
I
N
L
D
I
H
E
G
E
F
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
I
A
G
L
E
T
I
T
S
-
G
D
L
F
I
G
E
--
K
R
M
----
N
D
------
T
------
P
P
A
-----
E
R
G
-
V
G
M
--------
V
F
Q
--
S
Y
A
L
Y
P
H
L
S
V
A
E
N
M
S
F
-
G
L
K
L
A
---
G
A
K
K
E
V
I
N
Q
--
R
V
N
Q
V
A
E
V
L
Q
-----
L
A
-
H
-
L
L
D
R
K
P
K
A
L
S
G
G
Q
R
Q
R
V
A
I
G
R
T
L
V
A
E
P
S
V
F
L
L
D
E
P
L
S
N
L
D
---
A
A
L
R
V
Q
M
R
I
E
I
S
R
L
H
K
R
L
G
R
T
M
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
K
I
V
V
L
D
A
G
R
V
A
Q
V
G
K
P
L
E
L
Y
H
Y
P
A
D
R
F
V
A
G
F
I
G
--
S
P
KM
N
F
L
P
VKVT
A
T
A
I
D
Q
V
Q
--
V
--
E
L
-
P
-------
M
P
N
----
R
-------
Q
Q
V
WLPVE
S
-
R
D
V
Q
V
G
A
N
M
S
L
G
I
R
P
E
H
L
---------
L
P
S
------
D
-------
I
A
D
V
I
L
E
G
---
E
V
Q
V
V
E
Q
L
G
N
E
T
-
Q
I
H
IQIP
S
--
I
R
Q
N
L
V
YRQNDVVLVEE--
G
A
T
F
A
I
G
L
P
P
E
R
C
H
L
F
R
E
D
G
T
-----------------------------------
147
HHSearch
73.68
42%
11
- C2 -
-
2D62
1
?
A:
[4-373]
--
M
A
E
-
V
K
L
I
N
I
W
K
R
F
G
--
D
------
V
T
A
V
K
D
L
S
L
E
I
K
D
G
E
F
L
V
L
L
G
P
S
G
C
G
K
T
T
T
L
R
M
I
A
G
L
E
E
P
T
R
-
G
Q
I
Y
I
E
D
--
N
L
V
----
A
D
------
P
EKG
V
F
V
P
P
K
-----
E
R
D
-
V
A
M
--------
V
F
Q
--
S
Y
A
L
Y
P
H
M
T
V
Y
D
N
I
A
F
-
P
L
K
L
R
---
K
V
P
K
Q
E
I
D
K
--
R
V
R
E
V
A
E
M
L
G
-----
L
T
-
E
-
L
L
N
R
K
P
R
E
L
S
G
G
Q
R
Q
R
V
A
L
G
R
A
I
I
R
R
P
K
V
F
L
M
D
E
P
L
S
N
L
D
---
A
K
L
R
V
K
M
R
A
E
L
K
K
L
Q
R
Q
L
G
V
T
T
I
Y
V
T
H
D
Q
V
E
A
M
T
M
G
D
R
I
A
V
M
N
K
G
E
L
Q
Q
V
G
T
P
D
E
V
Y
Y
K
P
V
N
T
F
V
A
G
F
I
G
--
S
P
P
M
N
F
L
D
----
A
T
I
T
D
D
G
F
--
L
--
D
F
-
G
-------
E
F
K
----
L
K
L
L
Q
D
Q
F
E
V
L
-----
E
-
E
E
N
M
V
G
K
E
V
I
F
G
I
R
P
E
D
V
------
H
D
A
S
F
T
HIDVPE
E
N
-
T
V
K
A
T
V
D
I
I
E
N
L
G
G
E
K
I
V
H
L
-
R
R
G
N
I
S
F
-
T
A
K
----
F
P
K
E
S
K
V
R
E
-------------
G
D
E
V
S
V
V
F
D
M
K
K
I
H
I
F
R
K
D
T
E
K
A
---------------------------------
3
PsiBlast_PDB
71.50
40%
2
- C2 -
-
2D62
1
?
A:
[7-367]
------
V
K
L
I
N
I
W
K
R
F
G
--
D
-
V
T
---
A
--
V
K
D
L
S
L
E
I
K
D
G
E
F
L
V
L
L
G
P
S
G
C
G
K
T
T
T
L
R
M
I
A
G
L
E
E
P
T
R
-
G
Q
I
Y
I
E
D
--
N
L
V
----
A
D
PEKG
V
F
V
------
P
P
K
-----
E
R
D
-
V
A
M
--------
V
F
Q
--
S
Y
A
L
Y
P
H
M
T
V
Y
D
N
I
A
F
-
P
L
K
L
R
---
K
V
P
K
Q
E
I
D
K
--
R
V
R
E
V
A
E
M
L
G
-----
L
T
-
E
-
L
L
N
R
K
P
R
E
L
S
G
G
Q
R
Q
R
V
A
L
G
R
A
I
I
R
R
P
K
V
F
L
M
D
E
P
L
S
N
L
D
---
A
K
L
R
V
K
M
R
A
E
L
K
K
L
Q
R
Q
L
G
V
T
T
I
Y
V
T
H
D
Q
V
E
A
M
T
M
G
D
R
I
A
V
M
N
K
G
E
L
Q
Q
V
G
T
P
D
E
V
Y
Y
K
P
V
N
T
F
V
A
G
F
I
G
--
S
P
P
M
N
F
L
D
----
A
T
I
T
D
D
G
F
--
L
--
D
F
-
G
E
F
K
L
K
L
L
Q
D
Q
----
F
-------
E
V
L
-----
E
-
E
E
N
M
V
G
K
E
V
I
F
G
I
R
P
E
D
V
HDASFT
H
I
D
V
P
E
------
E
N
-
T
V
K
A
T
V
D
I
------------
I
E
N
L
G
G
E
K
-
I
V
H
----
L
--
R
R
G
N
I
S
F
T
A
K
F
P
KESKVRE
G
D
E
V
S
V
V
F
D
M
K
K
I
H
I
F
R
---------------------------------------
9
PsiBlast_PDB
67.59
46%
-131
- C2 -
-
1VCI
1
?
A:
[13-274]
------
V
K
L
E
N
L
T
K
R
F
-----
G
N
---
F
T
A
V
N
K
L
N
L
T
I
K
D
G
E
F
L
V
L
L
G
P
S
G
C
G
K
T
T
T
L
R
M
I
A
G
L
E
E
P
T
E
-
G
R
I
Y
F
G
D
--
R
D
V
----
T
Y
------
L
------
P
P
K
-----
D
R
N
-
I
S
M
--------
V
F
Q
--------
H
M
T
V
Y
E
N
I
A
F
-
P
L
--
K
---
K
F
P
K
D
E
I
D
K
--
R
V
R
W
A
A
E
L
L
Q
-----
I
E
-
E
-
L
L
N
R
Y
P
A
Q
L
S
G
G
Q
R
Q
R
V
A
V
A
R
A
I
V
V
E
P
D
V
L
L
M
D
E
P
L
S
N
L
D
---
A
K
L
R
V
A
M
R
A
E
I
K
K
L
Q
Q
K
L
K
V
T
T
I
Y
V
T
H
D
Q
V
E
A
M
T
M
G
D
R
I
A
V
M
N
R
G
Q
L
L
Q
I
G
S
P
T
E
V
Y
L
R
P
N
S
V
F
V
A
T
F
I
G
AP
E
M
--
N
I
L
E
----
V
S
V
G
D
G
Y
L
-----
E
G
-
R
-------
G
F
R
----
I
-------
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------
138
HHSearch
59.29
30%
-13
- C2 -
-
3FVQ
2
FBPC_NEIG1
B:
[3-351]
---
A
A
-
L
H
I
G
H
L
S
K
S
F
Q
--
N
------
T
P
V
L
N
D
I
S
L
S
L
D
P
G
E
I
L
F
I
I
G
A
S
G
C
G
K
T
T
L
L
R
C
L
A
G
F
E
Q
P
D
S
-
G
E
I
S
L
S
G
--
K
T
I
----
F
S
------
K
NTNL--
P
V
R
-----
E
R
R
-
L
G
Y
--------
L
V
Q
--
E
G
V
L
F
P
H
L
T
V
Y
R
N
I
A
Y
-
G
L
G
N
G
---
K
G
R
T
A
Q
E
R
Q
--
R
I
E
A
M
L
E
L
T
G
-----
I
S
-
E
-
L
A
G
R
Y
P
H
E
L
S
G
G
Q
Q
Q
R
A
A
L
A
R
A
L
A
P
D
P
E
L
I
L
L
D
E
P
F
S
A
L
D
---
E
Q
L
R
R
Q
I
R
E
D
M
I
A
A
L
R
A
N
G
K
S
A
V
F
V
S
H
D
R
E
E
A
L
Q
Y
A
D
R
I
A
V
M
K
Q
G
R
I
L
Q
T
A
S
P
H
E
L
Y
R
Q
P
A
D
L
D
A
A
L
F
I
G
--
E
G
--
I
V
F
P
----
A
A
L
N
A
D
G
T
--
A
--
D
C
-
R
-------
L
G
R
----
L
-------
P
V
------
Q
-
S
G
A
P
A
G
T
R
G
T
L
L
I
R
P
E
Q
Y
------
S
L
H
P
H
S
AP----
A
A
-
S
I
H
A
V
V
L
K
T
T
P
K
A
R
H
T
E
I
S
L
-
R
A
G
Q
T
V
L
-
T
L
N
LP--
S
--
A
P
T
L
S
D
-------------
G
I
S
A
V
L
H
L
D
G
P
A
L
F
F
P
G
N
T
-------------------------------------
58
PsiBlast_CBE
58.60
35%
-11
- C2 -
-
3FVQ
2
FBPC_NEIG1
B:
[5-281]
------
L
H
I
G
H
L
S
K
S
F
Q
-----
N
---
T
P
V
L
N
D
I
S
L
S
L
D
P
G
E
I
L
F
I
I
G
A
S
G
C
G
K
T
T
L
L
R
C
L
A
G
F
E
Q
P
D
S
-
G
E
I
S
L
S
G
--
K
T
I
FSKN
T
N
------
L
------
P
V
R
-----
E
R
R
-
L
G
Y
--------
L
V
Q
--
E
G
V
L
F
P
H
L
T
V
Y
R
N
I
A
Y
-
G
L
G
N
G
---
K
G
R
T
A
Q
E
R
Q
--
R
I
E
A
M
L
E
L
T
G
-----
I
S
-
E
-
L
A
G
R
Y
P
H
E
L
S
G
G
Q
Q
Q
R
A
A
L
A
R
A
L
A
P
D
P
E
L
I
L
L
D
E
P
F
S
A
L
D
---
E
Q
L
R
R
Q
I
R
E
D
M
I
A
A
L
R
A
N
G
K
S
A
V
F
V
S
H
D
R
E
E
A
L
Q
Y
A
D
R
I
A
V
M
K
Q
G
R
I
L
Q
T
A
S
P
H
E
L
Y
R
Q
P
A
D
L
D
A
A
L
F
I
G
--
E
G
--
I
V
F
P
----
A
A
L
N
A
D
G
T
--
A
--
D
C
-
R
-------
L
G
R
----
L
-------
P
-
V
-----
Q
-
S
G
A
P
A
G
T
R
G
T
L
L
I
R
P
E
-----------------------------------------------------------------------------------------------------------------------------------------
59
PsiBlast_CBE
57.32
35%
-15
- C2 -
-
3FVQ
2
FBPC_NEIG1
A:
[5-286]
------
L
H
I
G
H
L
S
K
S
F
Q
-----
N
---
T
P
V
L
N
D
I
S
L
S
L
D
P
G
E
I
L
F
I
I
G
A
S
G
C
G
K
T
T
L
L
R
C
L
A
G
F
E
Q
P
D
S
-
G
E
I
S
L
S
G
--
K
T
I
FSKN
T
N
------
L
------
P
V
R
-----
E
R
R
-
L
G
Y
--------
L
V
Q
--
E
G
V
L
F
P
H
L
T
V
Y
R
N
I
A
Y
-
G
L
G
N
G
---
K
G
R
T
A
Q
E
R
Q
--
R
I
E
A
M
L
E
L
T
G
-----
I
S
-
E
-
L
A
G
R
Y
P
H
E
L
S
G
G
Q
Q
Q
R
A
A
L
A
R
A
L
A
P
D
P
E
L
I
L
L
D
E
P
F
S
A
L
D
---
E
Q
L
R
R
Q
I
R
E
D
M
I
A
A
L
R
A
N
G
K
S
A
V
F
V
S
H
D
R
E
E
A
L
Q
Y
A
D
R
I
A
V
M
K
Q
G
R
I
L
Q
T
A
S
P
H
E
L
Y
R
Q
P
A
D
L
D
A
A
L
F
I
G
--
E
G
--
I
V
F
P
----
A
A
L
N
A
D
G
T
--
A
--
D
C
-
R
-------
L
G
R
----
L
-------
P
-
V
-----
Q
-
S
G
A
P
A
G
T
R
G
T
L
L
I
R
P
E
-----------------------------------------------------------------------------------------------------------------------------------------
81
PsiBlast_CBE
48.12
35%
-19
- C2 -
-
2OLK
1
?
C:
[24-261]
----
M
-
I
D
V
H
Q
L
K
K
S
F
-----
G
S
---
L
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
-
G
E
I
I
I
D
G
--
I
N
L
----
K
A
------
K
------
D
T
N
LNKV-
R
E
E
-
V
G
M
--------
V
F
Q
--
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P
M
K
V
R
---
K
W
P
R
E
K
A
E
A
--
K
A
M
E
L
L
D
K
V
G
-----
L
K
-
D
-
K
A
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
---
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
--
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
80
PsiBlast_CBE
47.18
35%
-15
- C2 -
-
2OLK
1
?
D:
[24-261]
----
M
-
I
D
V
H
Q
L
K
K
S
F
-----
G
S
---
L
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
-
G
E
I
I
I
D
G
--
I
N
L
----
K
A
------
K
------
D
T
N
LNKV-
R
E
E
-
V
G
M
--------
V
F
Q
--
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P
M
K
V
R
---
K
W
P
R
E
K
A
E
A
--
K
A
M
E
L
L
D
K
V
G
-----
L
K
-
D
-
K
A
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
---
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
--
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
73
PsiBlast_CBE
46.61
35%
-17
- C2 -
-
3C4J
2
?
A:
[24-261]
----
M
-
I
D
V
H
Q
L
K
K
S
F
-----
G
S
---
L
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
-
G
E
I
I
I
D
G
--
I
N
L
----
K
A
------
K
------
D
T
N
L
N
K
V
-
R
E
E
-
V
G
M
--------
V
F
Q
--
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P
M
K
V
R
---
K
W
P
R
E
K
A
E
A
--
K
A
M
E
L
L
D
K
V
G
-----
L
K
-
D
-
K
A
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
---
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
--
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
86
PsiBlast_CBE
45.89
35%
-15
- C2 -
-
3C41
2
?
K:
[3-240]
----
M
-
I
D
V
H
Q
L
K
K
S
F
-----
G
S
---
L
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
-
G
E
I
I
I
D
G
--
I
N
L
----
K
A
------
K
------
D
T
N
LNKV-
R
E
E
-
V
G
M
--------
V
F
Q
--
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P
M
K
V
R
---
K
W
P
R
E
K
A
E
A
--
K
A
M
E
L
L
D
K
V
G
-----
L
K
-
D
-
K
A
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
---
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
--
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
82
PsiBlast_CBE
45.43
35%
-15
- C2 -
-
2OLK
2
?
B:
[24-261]
----
M
-
I
D
V
H
Q
L
K
K
S
F
-----
G
S
---
L
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
-
G
E
I
I
I
D
G
--
I
N
L
----
K
A
------
K
------
D
T
N
LNKV-
R
E
E
-
V
G
M
--------
V
F
Q
--
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P
M
K
V
R
---
K
W
P
R
E
K
A
E
A
--
K
A
M
E
L
L
D
K
V
G
-----
L
K
-
D
-
K
A
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
---
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
--
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
84
PsiBlast_CBE
45.11
35%
-13
- C2 -
-
2OLJ
2
?
B:
[24-261]
----
M
-
I
D
V
H
Q
L
K
K
S
F
-----
G
S
---
L
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
-
G
E
I
I
I
D
G
--
I
N
L
----
K
A
------
K
------
D
T
N
LNKV-
R
E
E
-
V
G
M
--------
V
F
Q
--
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P
M
K
V
R
---
K
W
P
R
E
K
A
E
A
--
K
A
M
E
L
L
D
K
V
G
-----
L
K
-
D
-
K
A
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
---
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
--
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
75
PsiBlast_CBE
44.72
35%
-15
- C2 -
-
2Q0H
3
?
A:
[24-261]
----
M
-
I
D
V
H
Q
L
K
K
S
F
-----
G
S
---
L
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
-
G
E
I
I
I
D
G
--
I
N
L
----
K
A
------
K
------
D
T
N
L
N
K
V
-
R
E
E
-
V
G
M
--------
V
F
Q
--
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P
M
K
V
R
---
K
W
P
R
E
K
A
E
A
--
K
A
M
E
L
L
D
K
V
G
-----
L
K
-
D
-
K
A
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
---
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
--
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
87
PsiBlast_CBE
43.89
35%
-16
- C2 -
-
3C41
2
?
J:
[3-240]
----
M
-
I
D
V
H
Q
L
K
K
S
F
-----
G
S
---
L
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
-
G
E
I
I
I
D
G
--
I
N
L
----
K
A
------
K
------
D
T
N
LNKV-
R
E
E
-
V
G
M
--------
V
F
Q
--
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P
M
K
V
R
---
K
W
P
R
E
K
A
E
A
--
K
A
M
E
L
L
D
K
V
G
-----
L
K
-
D
-
K
A
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
---
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
--
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
72
PsiBlast_CBE
43.78
35%
-13
- C2 -
-
3C4J
2
?
B:
[24-261]
----
M
-
I
D
V
H
Q
L
K
K
S
F
-----
G
S
---
L
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
-
G
E
I
I
I
D
G
--
I
N
L
----
K
A
------
K
------
D
T
N
LNKV-
R
E
E
-
V
G
M
--------
V
F
Q
--
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P
M
K
V
R
---
K
W
P
R
E
K
A
E
A
--
K
A
M
E
L
L
D
K
V
G
-----
L
K
-
D
-
K
A
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
---
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
--
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
90
PsiBlast_CBE
39.17
37%
14
- C2 -
-
3TIF
4
Y796_METJA
B:
[1-223]
----
M
-
V
K
L
K
N
V
T
K
T
Y
K
MG
E
-
E
I
---
I
Y
A
L
K
N
V
N
L
N
I
K
E
G
E
F
V
S
I
M
G
P
S
G
S
G
K
S
T
M
L
N
I
I
G
C
L
D
K
P
T
E
-
G
E
V
Y
I
D
N
--
I
K
T
----
N
D
------
L
------
D
D
D
ELTKI
R
R
D
K
I
G
F
--------
V
F
Q
--
Q
F
N
L
I
P
L
L
T
A
L
E
N
V
E
L
-
P
L
I
F
K
YRG
A
M
S
G
E
E
R
R
K
--
R
A
L
E
C
L
K
M
A
E
-----
L
E
E
R
-
F
A
N
H
K
P
N
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
N
N
P
P
I
I
L
A
D
Q
P
T
W
A
L
D
---
S
K
T
G
E
K
I
M
Q
L
L
K
K
L
N
E
E
D
G
K
T
V
V
V
V
T
H
D
I
N
V
A
-
R
F
G
E
R
I
I
Y
L
K
D
G
E
V
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
56
PsiBlast_CBE
37.55
37%
47
- C2 -
-
4YMU
1
?
J:
[4-238]
-----------
V
N
D
V
Y
K
--
N
F
G
S
---
L
E
V
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
K
-
G
E
V
F
I
D
G
--
V
K
I
----
N
N
------
G
------
K
V
N
INKV-
R
Q
K
-
V
G
M
--------
V
F
Q
--
H
F
N
L
F
P
H
L
T
A
I
E
N
I
T
L
A
P
V
K
V
K
---
K
M
N
K
K
E
A
E
E
--
L
A
V
D
L
L
A
K
V
G
-----
L
L
-
D
-
K
K
D
Q
Y
P
I
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
---
P
E
M
V
K
E
V
L
N
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
G
V
I
V
E
E
G
T
P
E
E
I
F
Y
R
A
K
N
E
R
T
R
E
F
L
S
--
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
57
PsiBlast_CBE
37.09
37%
48
- C2 -
-
4YMU
1
?
A:
[4-238]
-----------
V
N
D
V
Y
K
--
N
F
G
S
---
L
E
V
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
K
-
G
E
V
F
I
D
G
--
V
K
I
----
N
N
------
G
------
K
V
N
I
N
K
V
-
R
Q
K
-
V
G
M
--------
V
F
Q
--
H
F
N
L
F
P
H
L
T
A
I
E
N
I
T
L
A
P
V
K
V
K
---
K
M
N
K
K
E
A
E
E
--
L
A
V
D
L
L
A
K
V
G
-----
L
L
-
D
-
K
K
D
Q
Y
P
I
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
---
P
E
M
V
K
E
V
L
N
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
G
V
I
V
E
E
G
T
P
E
E
I
F
Y
R
A
K
N
E
R
T
R
E
F
L
S
--
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
55
PsiBlast_CBE
36.21
37%
50
- C2 -
-
4YMV
1
?
A:
[4-238]
-----------
V
N
D
V
Y
K
--
N
F
G
S
---
L
E
V
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
K
-
G
E
V
F
I
D
G
--
V
K
I
----
N
N
------
G
------
K
V
N
I
N
K
V
-
R
Q
K
-
V
G
M
--------
V
F
Q
--
H
F
N
L
F
P
H
L
T
A
I
E
N
I
T
L
A
P
V
K
V
K
---
K
M
N
K
K
E
A
E
E
--
L
A
V
D
L
L
A
K
V
G
-----
L
L
-
D
-
K
K
D
Q
Y
P
I
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
---
P
E
M
V
K
E
V
L
N
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
G
V
I
V
E
E
G
T
P
E
E
I
F
Y
R
A
K
N
E
R
T
R
E
F
L
S
--
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
92
PsiBlast_CBE
35.43
33%
34
- C2 -
-
4MKI
2
ECFA2_CALS4
B:
[5-238]
----
M
P
I
K
V
E
N
V
S
F
I
Y
N
--
E
-
G
T
PYA
T
V
A
L
K
D
I
N
F
S
I
D
D
E
E
F
V
G
I
I
G
H
T
G
S
G
K
S
T
L
I
Q
Q
L
N
G
L
L
K
P
S
K
-
G
K
I
Y
I
N
G
--
I
D
I
----
T
D
------
K
------
K
V
S
-----
L
K
D
-
I
R
K
Q
V
G
L
----
V
F
Q
YP
E
Y
Q
L
F
E
E
-
T
V
F
K
D
I
A
F
-
G
P
S
N
L
---
G
L
S
E
E
E
V
K
E
--
R
V
Y
E
A
M
E
I
V
G
-----
I
S
-
K
E
L
A
D
K
S
P
F
E
L
S
G
G
Q
K
R
R
V
A
I
A
G
I
L
A
M
R
P
K
I
L
I
L
D
E
P
T
A
G
L
D
---
P
K
G
K
Q
E
I
L
N
K
I
K
E
I
H
D
K
Y
K
M
I
T
I
L
V
S
H
N
M
E
D
I
A
R
I
A
D
K
I
I
V
M
N
R
G
K
I
E
L
I
G
T
P
R
E
V
F
R
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
93
PsiBlast_CBE
34.23
33%
38
- C2 -
-
4MKI
2
ECFA2_CALS4
A:
[3-238]
--
R
P
M
P
I
K
V
E
N
V
S
F
I
Y
N
--
E
-
G
T
PYA
T
V
A
L
K
D
I
N
F
S
I
D
D
E
E
F
V
G
I
I
G
H
T
G
S
G
K
S
T
L
I
Q
Q
L
N
G
L
L
K
P
S
K
-
G
K
I
Y
I
N
G
--
I
D
I
----
T
D
------
K
------
K
V
S
-----
L
K
D
-
I
R
K
Q
V
G
L
----
V
F
Q
YP
E
Y
Q
L
F
E
E
-
T
V
F
K
D
I
A
F
-
G
P
S
N
L
---
G
L
S
E
E
E
V
K
E
--
R
V
Y
E
A
M
E
I
V
G
-----
I
S
-
K
E
L
A
D
K
S
P
F
E
L
S
G
G
Q
K
R
R
V
A
I
A
G
I
L
A
M
R
P
K
I
L
I
L
D
E
P
T
A
G
L
D
---
P
K
G
K
Q
E
I
L
N
K
I
K
E
I
H
D
K
Y
K
M
I
T
I
L
V
S
H
N
M
E
D
I
A
R
I
A
D
K
I
I
V
M
N
R
G
K
I
E
L
I
G
T
P
R
E
V
F
R
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
103
PsiBlast_CBE
33.30
35%
-4
- C2 -
-
2PCL
5
LOLD_AQUAE
A:
[4-218]
----
I
-
L
R
A
E
N
I
K
K
V
I
R
-----
G
---
Y
E
I
L
K
G
I
S
L
S
V
K
K
G
E
F
V
S
I
I
G
A
S
G
S
G
K
S
T
L
L
Y
I
L
-
G
L
L
D
A
P
T
E
G
K
V
F
L
E
G
--
K
E
V
----
D
Y
--------------
T
N
-----
E
K
E
-
L
S
L
L
R
N
R
K
L
G
F
V
F
Q
--
F
H
Y
L
I
P
E
L
T
A
L
E
N
V
I
V
-
P
M
L
K
M
---
G
K
P
K
K
E
A
K
E
--
R
G
E
Y
L
L
S
E
L
G
-----
L
G
-
D
-
K
L
S
R
K
P
Y
E
L
S
G
G
E
Q
Q
R
V
A
I
A
R
A
L
A
N
E
P
I
L
L
F
A
D
E
P
T
G
N
L
D
S
A
N
T
K
R
V
M
D
I
F
L
K
I
N
E
----
G
G
T
S
I
V
M
V
T
H
E
R
E
L
A
-
E
L
T
H
R
T
L
E
M
K
D
G
K
V
V
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
129
PsiBlast_CBE
18.91
33%
-
- C2 -
-
3B5Y
2
MSBA_SALTY
B:
[342-561]
------
L
E
F
R
N
V
T
F
T
Y
P
--
G
-
R
E
---
V
P
A
L
R
N
I
N
L
K
I
P
A
G
K
T
V
A
L
V
G
R
S
G
S
G
K
S
T
I
A
S
L
I
T
R
F
Y
D
I
D
E
-
G
H
I
L
M
D
G
HD
L
R
E
----
Y
T
------
L
------
A
S
L
-----
R
N
Q
-
V
A
L
--------
V
S
Q
--
N
V
H
L
F
N
D
-
T
V
A
N
N
I
A
Y
-
A
-
R
T
E
---
E
Y
S
R
E
Q
I
E
E
AA
R
M
A
Y
A
M
D
F
I
N
KMDNG
L
D
-
T
-
I
I
G
E
N
G
V
L
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
L
R
D
S
P
I
L
I
L
D
E
A
T
S
A
L
D
---
T
E
S
E
R
A
I
Q
A
A
L
D
E
L
Q
K
N
R
--
T
S
L
V
I
A
H
-
R
L
S
T
I
E
Q
A
D
E
I
V
V
V
E
D
G
I
I
V
E
R
G
T
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
128
PsiBlast_CBE
18.88
33%
-
- C2 -
-
3B5Y
2
MSBA_SALTY
C:
[342-561]
------
L
E
F
R
N
V
T
F
T
Y
P
--
G
-
R
E
---
V
P
A
L
R
N
I
N
L
K
I
P
A
G
K
T
V
A
L
V
G
R
S
G
S
G
K
S
T
I
A
S
L
I
T
R
F
Y
D
I
D
E
-
G
H
I
L
M
D
G
HD
L
R
E
----
Y
T
------
L
------
A
S
L
-----
R
N
Q
-
V
A
L
--------
V
S
Q
--
N
V
H
L
F
N
D
-
T
V
A
N
N
I
A
Y
-
A
-
R
T
E
---
E
Y
S
R
E
Q
I
E
E
AA
R
M
A
Y
A
M
D
F
I
N
KMDNG
L
D
-
T
-
I
I
G
E
N
G
V
L
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
L
R
D
S
P
I
L
I
L
D
E
A
T
S
A
L
D
---
T
E
S
E
R
A
I
Q
A
A
L
D
E
L
Q
K
N
R
--
T
S
L
V
I
A
H
-
R
L
S
T
I
E
Q
A
D
E
I
V
V
V
E
D
G
I
I
V
E
R
G
T
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
127
PsiBlast_CBE
18.88
33%
-
- C2 -
-
3B5Y
2
MSBA_SALTY
D:
[342-561]
------
L
E
F
R
N
V
T
F
T
Y
P
--
G
-
R
E
---
V
P
A
L
R
N
I
N
L
K
I
P
A
G
K
T
V
A
L
V
G
R
S
G
S
G
K
S
T
I
A
S
L
I
T
R
F
Y
D
I
D
E
-
G
H
I
L
M
D
G
HD
L
R
E
----
Y
T
------
L
------
A
S
L
-----
R
N
Q
-
V
A
L
--------
V
S
Q
--
N
V
H
L
F
N
D
-
T
V
A
N
N
I
A
Y
-
A
-
R
T
E
---
E
Y
S
R
E
Q
I
E
E
AA
R
M
A
Y
A
M
D
F
I
N
KMDNG
L
D
-
T
-
I
I
G
E
N
G
V
L
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
L
R
D
S
P
I
L
I
L
D
E
A
T
S
A
L
D
---
T
E
S
E
R
A
I
Q
A
A
L
D
E
L
Q
K
N
R
--
T
S
L
V
I
A
H
-
R
L
S
T
I
E
Q
A
D
E
I
V
V
V
E
D
G
I
I
V
E
R
G
T
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
126
PsiBlast_CBE
18.85
33%
-
- C2 -
-
3B5Z
2
MSBA_SALTY
A:
[342-561]
------
L
E
F
R
N
V
T
F
T
Y
P
--
G
-
R
E
---
V
P
A
L
R
N
I
N
L
K
I
P
A
G
K
T
V
A
L
V
G
R
S
G
S
G
K
S
T
I
A
S
L
I
T
R
F
Y
D
I
D
E
-
G
H
I
L
M
D
G
HD
L
R
E
----
Y
T
------
L
------
A
S
L
-----
R
N
Q
-
V
A
L
--------
V
S
Q
--
N
V
H
L
F
N
D
-
T
V
A
N
N
I
A
Y
-
A
-
R
T
E
---
E
Y
S
R
E
Q
I
E
E
A
A
R
M
A
Y
A
M
D
F
I
N
K
M
DNG
L
D
-
T
-
I
I
G
E
N
G
V
L
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
L
R
D
S
P
I
L
I
L
D
E
A
T
S
A
L
D
---
T
E
S
E
R
A
I
Q
A
A
L
D
E
L
Q
K
N
R
--
T
S
L
V
I
A
H
-
R
L
S
T
I
E
Q
A
D
E
I
V
V
V
E
D
G
I
I
V
E
R
G
T
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
124
PsiBlast_CBE
18.85
33%
-
- C2 -
-
3B5Z
2
MSBA_SALTY
C:
[342-561]
------
L
E
F
R
N
V
T
F
T
Y
P
--
G
-
R
E
---
V
P
A
L
R
N
I
N
L
K
I
P
A
G
K
T
V
A
L
V
G
R
S
G
S
G
K
S
T
I
A
S
L
I
T
R
F
Y
D
I
D
E
-
G
H
I
L
M
D
G
HD
L
R
E
----
Y
T
------
L
------
A
S
L
-----
R
N
Q
-
V
A
L
--------
V
S
Q
--
N
V
H
L
F
N
D
-
T
V
A
N
N
I
A
Y
-
A
-
R
T
E
---
E
Y
S
R
E
Q
I
E
E
AA
R
M
A
Y
A
M
D
F
I
N
KMDNG
L
D
-
T
-
I
I
G
E
N
G
V
L
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
L
R
D
S
P
I
L
I
L
D
E
A
T
S
A
L
D
---
T
E
S
E
R
A
I
Q
A
A
L
D
E
L
Q
K
N
R
--
T
S
L
V
I
A
H
-
R
L
S
T
I
E
Q
A
D
E
I
V
V
V
E
D
G
I
I
V
E
R
G
T
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