@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : spr1314: (2018-01-09 )
MIKISNLSKSFSGQTVLDHLDLDIQKGEVVALIGSSGAGKSTFLRSLNYLETPDSGSIQIDGFSVDFSKITQEEILALRRKLSMVFQQFNLFERRTALDNVKEGLVVVKKLSDQEATKIAKEELAKVGLSDRENHYPRHLSGGQKQRVALARALAMKPDVLLLDEPTSALDPELVGEVEKSIADAAKSGQTMILVSHDMSFVAQVADKILFLDKGKIIESGTPDEIIHTPKEERTKEFFASYKRTYI
Atome Classification :
(30 SA)
-.........10.-.-...---...20........30........40........50........60..-----------......--------70........-80.........90........100.......110.........120...----------....130-.......-----------140.......150....-...160.......170---......-.180....-...190.......200.......210..-.....220.......230-.......240.....
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
-
M
I
KISNLSKSFS-G-Q
T
V
---
L
D
HLDLDIQK
G
E
V
V
A
L
IGSSGA
G
K
S
T
F
L
R
SLNYLETPDS
G
S
I
Q
I
D
G
F
-----------
S
V
D
F
S
K--------I
T
Q
E
E
I
L
A
L
R
-
R
-
K
L
S
M
V
F
Q
Q
F
N
L
F
E
R
R
T
A
L
D
N
V
K
E
G
L
V
V
V
K
K--LS
D
Q
E
A
T
K
I
A
K
E
E
L
A
----------KVGLSDR-ENHYPRH-----------LSGG
Q
K
Q
R
V
A
L
A
R
A
LAM-KP
D
V
L
L
LDEPTSAL
D
P
---
E
L
V
G
E
V
-
E
K
S
I
A
D
A
A-KSG
Q
T
M
I
L
V
SH
D
M
S
F
V
A
Q
V
A
D
K
I
L
F
LDK-GKIIESGT
P
D
E
IIHTP
K
E
-
E
R
T
K
E
F
F
A
S
Y
K
R
TYI
22
PsiBlast_CBE
86.84
49%
-112
- C1 -
-
4YMU
1
?
A:
[1-237]
-
M
I
F
V
N
D
V
Y
K
N
F
G
-
S
-
L
E
V
---
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
K
G
E
V
F
I
D
G
V
-----------
K
I
N
N
G
K
--------
V
N
---
I
N
K
V
R
-
Q
-
K
V
G
M
V
F
Q
H
F
N
L
F
P
H
L
T
A
I
E
N
I
T
L
A
P
V
K
V
K
K
--
M
N
K
K
E
A
E
E
L
A
V
D
L
L
A
----------
K
V
G
L
L
D
K
-
K
D
Q
Y
P
I
K
-----------
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
-
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
---
E
M
V
K
E
V
-
L
N
V
M
K
Q
L
A
-
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
-
G
V
I
V
E
E
G
T
P
E
E
I
F
Y
R
A
K
N
-
E
R
T
R
E
F
L
S
-------
1
PsiBlast_PDB
86.48
49%
-108
- C1 -
-
4YMS
-
?
J:
[1-237]
-
M
I
F
V
N
D
V
Y
K
N
F
G
-
S
-
L
E
V
---
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
K
G
E
V
F
I
D
G
V
-----------
K
I
N
N
G
K
--------
V
N
---
I
N
K
V
R
-
Q
-
K
V
G
M
V
F
Q
H
F
N
L
F
P
H
L
T
A
I
E
N
I
T
L
A
P
V
K
V
K
K
--
M
N
K
K
E
A
E
E
L
A
V
D
L
L
A
----------
K
V
G
L
L
D
K
-
K
D
Q
Y
P
I
K
-----------
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
-
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
---
E
M
V
K
E
V
-
L
N
V
M
K
Q
L
A
-
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
-
G
V
I
V
E
E
G
T
P
E
E
I
F
Y
R
A
K
N
-
E
R
T
R
E
F
L
S
-------
31
PsiBlast_CBE
85.94
48%
-104
- C1 -
-
2OLK
1
?
D:
[24-260]
-
M
I
D
V
H
Q
L
K
K
S
F
G
-
S
-
L
E
V
---
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
I
-----------
N
L
---
K
--------
A
K
D
T
N
L
N
K
V
R
-
E
-
E
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P
M
K
V
R
K
--
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
----------
K
V
G
L
K
D
K
-
A
H
A
Y
P
D
S
-----------
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
-
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
---
E
M
V
G
E
V
-
L
S
V
M
K
Q
L
A
-
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
-
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
-
E
R
T
K
A
F
L
S
-------
3
PsiBlast_PDB
85.90
49%
-106
- C1 -
-
4YMU
1
?
J:
[1-237]
-
M
I
F
V
N
D
V
Y
K
N
F
G
-
S
-
L
E
V
---
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
K
G
E
V
F
I
D
G
V
-----------
K
I
N
N
G
K
--------
V
N
---
I
N
K
V
R
-
Q
-
K
V
G
M
V
F
Q
H
F
N
L
F
P
H
L
T
A
I
E
N
I
T
L
A
P
V
K
V
K
K
--
M
N
K
K
E
A
E
E
L
A
V
D
L
L
A
----------
K
V
G
L
L
D
K
-
K
D
Q
Y
P
I
K
-----------
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
-
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
---
E
M
V
K
E
V
-
L
N
V
M
K
Q
L
A
-
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
-
G
V
I
V
E
E
G
T
P
E
E
I
F
Y
R
A
K
N
-
E
R
T
R
E
F
L
S
-------
2
PsiBlast_PDB
85.84
49%
-108
- C1 -
-
4YMT
-
?
J:
[1-237]
-
M
I
F
V
N
D
V
Y
K
N
F
G
-
S
-
L
E
V
---
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
K
G
E
V
F
I
D
G
V
-----------
K
I
N
N
G
K
--------
V
N
---
I
N
K
V
R
-
Q
-
K
V
G
M
V
F
Q
H
F
N
L
F
P
H
L
T
A
I
E
N
I
T
L
A
P
V
K
V
K
K
--
M
N
K
K
E
A
E
E
L
A
V
D
L
L
A
----------
K
V
G
L
L
D
K
-
K
D
Q
Y
P
I
K
-----------
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
-
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
---
E
M
V
K
E
V
-
L
N
V
M
K
Q
L
A
-
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
-
G
V
I
V
E
E
G
T
P
E
E
I
F
Y
R
A
K
N
-
E
R
T
R
E
F
L
S
-------
8
PsiBlast_PDB
85.75
48%
-114
- C1 -
-
2OLJ
3
?
A:
[24-260]
-
M
I
D
V
H
Q
L
K
K
S
F
G
-
S
-
L
E
V
---
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
I
-----------
N
L
---
K
--------
A
K
D
T
N
L
N
K
V
R
-
E
-
E
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P
M
K
V
R
K
--
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
----------
K
V
G
L
K
D
K
-
A
H
A
Y
P
D
S
-----------
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
-
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
---
E
M
V
G
E
V
-
L
S
V
M
K
Q
L
A
-
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
-
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
-
E
R
T
K
A
F
L
S
-------
32
PsiBlast_CBE
85.74
48%
-114
- C1 -
-
2OLK
1
?
C:
[24-260]
-
M
I
D
V
H
Q
L
K
K
S
F
G
-
S
-
L
E
V
---
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
I
-----------
N
L
---
K
--------
A
K
D
T
N
L
N
K
V
R
-
E
-
E
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P
M
K
V
R
K
--
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
----------
K
V
G
L
K
D
K
-
A
H
A
Y
P
D
S
-----------
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
-
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
---
E
M
V
G
E
V
-
L
S
V
M
K
Q
L
A
-
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
-
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
-
E
R
T
K
A
F
L
S
-------
33
PsiBlast_CBE
85.31
48%
-106
- C1 -
-
2OLK
2
?
B:
[24-260]
-
M
I
D
V
H
Q
L
K
K
S
F
G
-
S
-
L
E
V
---
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
I
-----------
N
L
---
K
--------
A
K
D
T
N
L
N
K
V
R
-
E
-
E
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P
M
K
V
R
K
--
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
----------
K
V
G
L
K
D
K
-
A
H
A
Y
P
D
S
-----------
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
-
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
---
E
M
V
G
E
V
-
L
S
V
M
K
Q
L
A
-
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
-
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
-
E
R
T
K
A
F
L
S
-------
9
PsiBlast_PDB
85.09
48%
-114
- C1 -
-
2OLK
1
?
A:
[24-260]
-
M
I
D
V
H
Q
L
K
K
S
F
G
-
S
-
L
E
V
---
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
I
-----------
N
L
---
K
--------
A
K
D
T
N
L
N
K
V
R
-
E
-
E
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P
M
K
V
R
K
--
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
----------
K
V
G
L
K
D
K
-
A
H
A
Y
P
D
S
-----------
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
-
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
---
E
M
V
G
E
V
-
L
S
V
M
K
Q
L
A
-
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
-
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
-
E
R
T
K
A
F
L
S
-------
5
PsiBlast_PDB
85.08
49%
-108
- C1 -
-
4YMW
-
?
J:
[1-237]
-
M
I
F
V
N
D
V
Y
K
N
F
G
-
S
-
L
E
V
---
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
K
G
E
V
F
I
D
G
V
-----------
K
I
N
N
G
K
--------
V
N
---
I
N
K
V
R
-
Q
-
K
V
G
M
V
F
Q
H
F
N
L
F
P
H
L
T
A
I
E
N
I
T
L
A
P
V
K
V
K
K
--
M
N
K
K
E
A
E
E
L
A
V
D
L
L
A
----------
K
V
G
L
L
D
K
-
K
D
Q
Y
P
I
K
-----------
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
-
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
---
E
M
V
K
E
V
-
L
N
V
M
K
Q
L
A
-
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
-
G
V
I
V
E
E
G
T
P
E
E
I
F
Y
R
A
K
N
-
E
R
T
R
E
F
L
S
-------
10
PsiBlast_PDB
84.32
48%
-114
- C1 -
-
2OUK
-
?
A:
[24-260]
-
M
I
D
V
H
Q
L
K
K
S
F
G
-
S
-
L
E
V
---
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
I
-----------
N
L
---
K
--------
A
K
D
T
N
L
N
K
V
R
-
E
-
E
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P
M
K
V
R
K
--
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
----------
K
V
G
L
K
D
K
-
A
H
A
Y
P
D
S
-----------
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
-
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
---
E
M
V
G
E
V
-
L
S
V
M
K
Q
L
A
-
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
-
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
-
E
R
T
K
A
F
L
S
-------
21
PsiBlast_CBE
84.23
49%
-111
- C1 -
-
4YMV
1
?
A:
[1-237]
-
M
I
F
V
N
D
V
Y
K
N
F
G
-
S
-
L
E
V
---
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
K
G
E
V
F
I
D
G
V
-----------
K
I
N
N
G
K
--------
V
N
---
I
N
K
V
R
-
Q
-
K
V
G
M
V
F
Q
H
F
N
L
F
P
H
L
T
A
I
E
N
I
T
L
A
P
V
K
V
K
K
--
M
N
K
K
E
A
E
E
L
A
V
D
L
L
A
----------
K
V
G
L
L
D
K
-
K
D
Q
Y
P
I
K
-----------
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
-
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
---
E
M
V
K
E
V
-
L
N
V
M
K
Q
L
A
-
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
-
G
V
I
V
E
E
G
T
P
E
E
I
F
Y
R
A
K
N
-
E
R
T
R
E
F
L
S
-------
6
PsiBlast_PDB
84.09
47%
-100
- C1 -
-
4U00
1
?
A:
[4-238]
-
I
I
R
I
R
N
L
H
K
W
F
G
-
P
-
L
H
V
---
L
K
G
I
H
L
E
V
A
P
G
E
K
L
V
I
I
G
P
S
G
S
G
K
S
T
L
I
R
T
I
N
R
L
E
D
F
Q
E
G
E
V
V
V
D
G
L
-----------
S
V
K
D
D
R
--------
A
L
R
E
----
I
R
-
R
-
E
V
G
M
V
F
Q
Q
F
N
L
F
P
H
M
T
V
L
E
N
V
T
L
A
P
M
R
V
R
R
--
W
P
R
E
K
A
E
K
K
A
L
E
L
L
E
----------
R
V
G
I
L
D
Q
-
A
R
K
Y
P
A
Q
-----------
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
M
-
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
---
E
M
V
G
E
V
-
L
D
V
M
R
D
L
A
-
Q
G
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
A
D
R
V
V
F
M
D
G
-
G
Q
I
V
E
E
G
R
P
E
E
I
F
T
R
P
K
E
-
E
R
T
R
S
F
L
--------
4
PsiBlast_PDB
83.97
49%
-109
- C1 -
-
4YMV
1
?
J:
[1-237]
-
M
I
F
V
N
D
V
Y
K
N
F
G
-
S
-
L
E
V
---
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
K
G
E
V
F
I
D
G
V
-----------
K
I
N
N
G
K
--------
V
N
---
I
N
K
V
R
-
Q
-
K
V
G
M
V
F
Q
H
F
N
L
F
P
H
L
T
A
I
E
N
I
T
L
A
P
V
K
V
K
K
--
M
N
K
K
E
A
E
E
L
A
V
D
L
L
A
----------
K
V
G
L
L
D
K
-
K
D
Q
Y
P
I
K
-----------
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
-
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
---
E
M
V
K
E
V
-
L
N
V
M
K
Q
L
A
-
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
-
G
V
I
V
E
E
G
T
P
E
E
I
F
Y
R
A
K
N
-
E
R
T
R
E
F
L
S
-------
7
PsiBlast_PDB
83.62
47%
-98
- C1 -
-
4U02
-
?
A:
[4-238]
-
I
I
R
I
R
N
L
H
K
W
F
G
-
P
-
L
H
V
---
L
K
G
I
H
L
E
V
A
P
G
E
K
L
V
I
I
G
P
S
G
S
G
K
S
T
L
I
R
T
I
N
R
L
E
D
F
Q
E
G
E
V
V
V
D
G
L
-----------
S
V
K
D
D
R
--------
A
L
R
E
----
I
R
-
R
-
E
V
G
M
V
F
Q
Q
F
N
L
F
P
H
M
T
V
L
E
N
V
T
L
A
P
M
R
V
R
R
--
W
P
R
E
K
A
E
K
K
A
L
E
L
L
E
----------
R
V
G
I
L
D
Q
-
A
R
K
Y
P
A
Q
-----------
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
M
-
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
---
E
M
V
G
E
V
-
L
D
V
M
R
D
L
A
-
Q
G
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
A
D
R
V
V
F
M
D
G
-
G
Q
I
V
E
E
G
R
P
E
E
I
F
T
R
P
K
E
-
E
R
T
R
S
F
L
--------
35
PsiBlast_CBE
83.51
48%
-107
- C1 -
-
3C41
2
?
K:
[3-239]
-
M
I
D
V
H
Q
L
K
K
S
F
G
-
S
-
L
E
V
---
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
I
-----------
N
L
---
K
--------
A
K
D
T
N
L
N
K
V
R
-
E
-
E
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P
M
K
V
R
K
--
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
----------
K
V
G
L
K
D
K
-
A
H
A
Y
P
D
S
-----------
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
-
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
---
E
M
V
G
E
V
-
L
S
V
M
K
Q
L
A
-
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
-
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
-
E
R
T
K
A
F
L
S
-------
26
PsiBlast_CBE
82.67
48%
-109
- C1 -
-
3C4J
2
?
B:
[24-260]
-
M
I
D
V
H
Q
L
K
K
S
F
G
-
S
-
L
E
V
---
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
I
-----------
N
L
---
K
--------
A
K
D
T
N
L
N
K
V
R
-
E
-
E
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P
M
K
V
R
K
--
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
----------
K
V
G
L
K
D
K
-
A
H
A
Y
P
D
S
-----------
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
-
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
---
E
M
V
G
E
V
-
L
S
V
M
K
Q
L
A
-
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
-
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
-
E
R
T
K
A
F
L
S
-------
27
PsiBlast_CBE
82.23
48%
-114
- C1 -
-
2Q0H
3
?
B:
[24-260]
-
M
I
D
V
H
Q
L
K
K
S
F
G
-
S
-
L
E
V
---
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
I
-----------
N
L
---
K
--------
A
K
D
T
N
L
N
K
V
R
-
E
-
E
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P
M
K
V
R
K
--
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
----------
K
V
G
L
K
D
K
-
A
H
A
Y
P
D
S
-----------
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
-
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
---
E
M
V
G
E
V
-
L
S
V
M
K
Q
L
A
-
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
-
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
-
E
R
T
K
A
F
L
S
-------
11
PsiBlast_PDB
82.01
48%
-104
- C1 -
-
2Q0H
3
?
A:
[24-260]
-
M
I
D
V
H
Q
L
K
K
S
F
G
-
S
-
L
E
V
---
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
I
-----------
N
L
---
K
--------
A
K
D
T
N
L
N
K
V
R
-
E
-
E
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P
M
K
V
R
K
--
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
----------
K
V
G
L
K
D
K
-
A
H
A
Y
P
D
S
-----------
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
-
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
---
E
M
V
G
E
V
-
L
S
V
M
K
Q
L
A
-
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
-
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
-
E
R
T
K
A
F
L
S
-------
13
PsiBlast_PDB
81.75
48%
-100
- C1 -
-
3C41
2
?
J:
[3-239]
-
M
I
D
V
H
Q
L
K
K
S
F
G
-
S
-
L
E
V
---
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
I
-----------
N
L
---
K
--------
A
K
D
T
N
L
N
K
V
R
-
E
-
E
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P
M
K
V
R
K
--
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
----------
K
V
G
L
K
D
K
-
A
H
A
Y
P
D
S
-----------
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
-
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
---
E
M
V
G
E
V
-
L
S
V
M
K
Q
L
A
-
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
-
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
-
E
R
T
K
A
F
L
S
-------
12
PsiBlast_PDB
81.62
48%
-103
- C1 -
-
3C4J
2
?
A:
[24-260]
-
M
I
D
V
H
Q
L
K
K
S
F
G
-
S
-
L
E
V
---
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
I
-----------
N
L
---
K
--------
A
K
D
T
N
L
N
K
V
R
-
E
-
E
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P
M
K
V
R
K
--
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
----------
K
V
G
L
K
D
K
-
A
H
A
Y
P
D
S
-----------
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
-
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
---
E
M
V
G
E
V
-
L
S
V
M
K
Q
L
A
-
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
-
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
-
E
R
T
K
A
F
L
S
-------
34
PsiBlast_CBE
80.07
48%
-103
- C1 -
-
2OLJ
2
?
B:
[24-260]
-
M
I
D
V
H
Q
L
K
K
S
F
G
-
S
-
L
E
V
---
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
I
-----------
N
L
---
K
--------
A
K
D
T
N
L
N
K
V
R
-
E
-
E
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P
M
K
V
R
K
--
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
----------
K
V
G
L
K
D
K
-
A
H
A
Y
P
D
S
-----------
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
-
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
---
E
M
V
G
E
V
-
L
S
V
M
K
Q
L
A
-
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
-
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
-
E
R
T
K
A
F
L
S
-------
14
PsiBlast_PDB
74.57
44%
-7
- C1 -
-
1B0U
1
HISP_SALTY
A:
[7-253]
--
L
H
V
I
D
L
H
K
R
Y
G
-
G
-
H
E
V
---
L
K
G
V
S
L
Q
A
R
A
G
D
V
I
S
I
I
G
S
S
G
S
G
K
S
T
F
L
R
C
I
N
F
L
E
K
P
S
E
G
A
I
I
V
N
G
Q
-----------
N
I
N
L
V
R
D
KDGQLKV
A
D
K
N
Q
L
R
L
L
R
-
T
-
R
L
T
M
V
F
Q
H
F
N
L
W
S
H
M
T
V
L
E
N
V
M
E
A
P
I
Q
V
L
G
--
L
S
K
H
D
A
R
E
R
A
L
K
Y
L
A
----------
K
V
G
I
D
E
R
A
Q
G
K
Y
P
V
H
-----------
L
S
G
G
Q
Q
Q
R
V
S
I
A
R
A
L
A
M
-
E
P
D
V
L
L
F
D
E
P
T
S
A
L
D
P
---
E
L
V
G
E
V
-
L
R
I
M
Q
Q
L
A
-
E
E
G
K
T
M
V
V
V
T
H
E
M
G
F
A
R
H
V
S
S
H
V
I
F
L
H
Q
-
G
K
I
E
E
E
G
D
P
E
Q
V
F
G
N
P
Q
S
-
P
R
L
Q
Q
F
L
--------
144
Fugue
64.40
45%
39
- C1 -
-
1B0U
1
HISP_SALTY
A:
[5-261]
N
K
L
H
V
I
D
L
H
K
R
Y
G
-
G
H
E
V
L
---
K
-
G
V
S
L
Q
A
R
A
G
D
V
I
S
I
I
G
S
S
G
S
G
K
S
T
F
L
R
C
I
N
F
L
E
K
P
S
E
G
A
I
I
V
N
G
-QNI
N
L
V
R
D
KDG
Q
L
K
V
A
D
--------
K
N
Q
L
R
L
L
R
T
--
R
--
L
T
M
V
F
Q
H
F
N
L
W
S
H
M
T
V
L
E
N
V
M
E
A
P
I
Q
V
L
-G-
L
S
K
H
D
A
R
E
R
A
L
K
Y
L
A
K
V
GIDERAQG----------
K
Y
P
V
H
-----------
L
S
G
G
Q
Q
Q
R
V
S
I
A
R
A
L
A
M
E-
P
D
V
L
L
F
D
E
P
T
S
A
L
D
P
---
E
L
V
G
E
V
-
L
R
I
M
Q
Q
L
A
-
E
E
G
K
T
M
V
V
V
T
H
E
M
G
F
A
R
H
V
S
S
H
V
I
F
L
H
-Q
G
K
I
E
E
E
G
D
P
E
Q
V
F
G
N
P
-
Q
S
P
R
L
Q
Q
F
L
K
G
S
L
K
K
L
E
153
HHSearch
64.25
37%
-95
- C1 -
-
3FVQ
2
FBPC_NEIG1
B:
[5-231]
--
L
H
I
G
H
L
S
K
S
F
Q
-
N
-
T
P
V
---
L
N
D
I
S
L
S
L
D
P
G
E
I
L
F
I
I
G
A
S
G
C
G
K
T
T
L
L
R
C
L
A
G
F
E
Q
P
D
S
G
E
I
S
L
S
G
K
-----------
T
I
F
S
K
-----------
N
T
N
L
P
V
R
E
-
R
-
R
L
G
Y
L
V
Q
E
G
V
L
F
P
H
L
T
V
Y
R
N
I
A
Y
G
L
G
N
G
K
G
---
R
T
A
Q
E
R
Q
R
I
E
A
M
L
E
----------
L
T
G
I
S
E
L
-
A
G
R
Y
P
H
E
-----------
L
S
G
G
Q
Q
Q
R
A
A
L
A
R
A
L
A
P
-
D
P
E
L
I
L
L
D
E
P
F
S
A
L
D
E
---
Q
L
R
R
Q
I
-
R
E
D
M
I
A
A
L
R
A
N
G
K
S
A
V
F
V
S
H
D
R
E
E
A
L
Q
Y
A
D
R
I
A
V
M
K
Q
-
G
R
I
L
Q
T
A
S
P
H
E
L
Y
R
Q
P
A
-----------------
88
PsiBlast_CBE
61.82
40%
-46
- C1 -
-
3FVQ
2
FBPC_NEIG1
A:
[5-237]
--
L
H
I
G
H
L
S
K
S
F
Q
-
N
-
T
P
V
---
L
N
D
I
S
L
S
L
D
P
G
E
I
L
F
I
I
G
A
S
G
C
G
K
T
T
L
L
R
C
L
A
G
F
E
Q
P
D
S
G
E
I
S
L
S
G
K
-----------
T
I
-
F
S
K
--------
N
T
N
---
L
P
V
R
E
R
-
R
L
G
Y
L
V
Q
E
G
V
L
F
P
H
L
T
V
Y
R
N
I
A
Y
G
L
G
N
G
K
G
--
R
T
A
Q
E
R
Q
R
I
-
E
A
M
L
E
----------
L
T
G
I
S
E
L
-
A
G
R
Y
P
H
E
-----------
L
S
G
G
Q
Q
Q
R
A
A
L
A
R
A
L
A
P
-
D
P
E
L
I
L
L
D
E
P
F
S
A
L
D
E
---
Q
L
R
R
Q
I
R
E
D
M
I
A
A
L
R
-
A
N
G
K
S
A
V
F
V
S
H
D
R
E
E
A
L
Q
Y
A
D
R
I
A
V
M
K
Q
-
G
R
I
L
Q
T
A
S
P
H
E
L
Y
R
Q
P
A
D
----------------
87
PsiBlast_CBE
61.75
40%
-42
- C1 -
-
3FVQ
2
FBPC_NEIG1
B:
[5-232]
--
L
H
I
G
H
L
S
K
S
F
Q
-
N
-
T
P
V
---
L
N
D
I
S
L
S
L
D
P
G
E
I
L
F
I
I
G
A
S
G
C
G
K
T
T
L
L
R
C
L
A
G
F
E
Q
P
D
S
G
E
I
S
L
S
G
K
-----------
T
I
-
F
S
K
--------
N
T
N
---
L
P
V
R
E
R
-
R
L
G
Y
L
V
Q
E
G
V
L
F
P
H
L
T
V
Y
R
N
I
A
Y
G
L
G
N
G
K
G
--
R
T
A
Q
E
R
Q
R
I
-
E
A
M
L
E
----------
L
T
G
I
S
E
L
-
A
G
R
Y
P
H
E
-----------
L
S
G
G
Q
Q
Q
R
A
A
L
A
R
A
L
A
P
-
D
P
E
L
I
L
L
D
E
P
F
S
A
L
D
E
---
Q
L
R
R
Q
I
R
E
D
M
I
A
A
L
R
-
A
N
G
K
S
A
V
F
V
S
H
D
R
E
E
A
L
Q
Y
A
D
R
I
A
V
M
K
Q
-
G
R
I
L
Q
T
A
S
P
H
E
L
Y
R
Q
P
A
D
----------------
51
PsiBlast_CBE
57.46
37%
38
- C1 -
-
3TIF
4
Y796_METJA
B:
[1-223]
-
M
V
K
L
K
N
V
T
K
T
Y
K
M
G
-
E
E
I
IYA
L
K
N
V
N
L
N
I
K
E
G
E
F
V
S
I
M
G
P
S
G
S
G
K
S
T
M
L
N
I
I
G
C
L
D
K
P
T
E
G
E
V
Y
I
D
-------------
N
I
K
T
N
D
--------
L
D
D
D
E
L
T
K
I
R
-
R
D
K
I
G
F
V
F
Q
Q
F
N
L
I
P
L
L
T
A
L
E
N
V
E
L
P
L
I
F
K
Y
R
GA
M
S
G
E
E
R
R
K
R
A
L
E
C
L
K
----------
M
A
E
L
E
E
R
F
A
N
H
K
P
N
Q
-----------
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
N
-
N
P
P
I
I
L
A
D
Q
P
T
W
A
L
D
S
KTG
E
K
I
M
Q
L
-
L
K
K
L
N
E
---
E
D
G
K
T
V
V
V
V
T
H
D
I
N
-
V
A
R
F
G
E
R
I
I
Y
L
K
D
-
G
E
V
-------------------------------
139
PsiBlast_CBE
52.75
35%
-22
- C1 -
-
4AYX
1
ABCBA_HUMAN
A:
[359-573]
------------------
I
---
F
Q
D
F
S
L
S
I
P
S
G
S
V
T
A
L
V
G
P
S
G
S
G
K
S
T
V
L
S
L
L
L
R
L
Y
D
P
A
S
G
T
I
S
L
D
G
----------------
H
D
--------
I
R
Q
L
N
P
V
W
L
R
-
S
-
K
I
G
T
V
S
Q
E
P
I
L
F
S
C
S
I
A
-
E
N
I
A
Y
G
A
D
D
P
S
S
--
V
T
A
E
E
I
Q
R
V
A
--
E
V
A
----------
N
A
V
A
F
I
R
---
N
F
P
Q
G
FN
T
V
V
G
EK
G
V
L
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
L
K
-
N
P
K
I
L
L
L
D
E
A
T
S
A
L
D
A
---
E
N
E
Y
L
V
-
Q
E
A
L
-
D
R
L
-
M
D
G
R
T
V
L
V
I
A
H
R
L
S
T
I
K
N
-
A
N
M
V
A
V
L
D
Q
-
G
K
I
T
E
Y
G
K
H
E
E
L
L
S
K
P
N
-----------------
140
PsiBlast_CBE
52.50
35%
-28
- C1 -
-
4AYT
1
ABCBA_HUMAN
A:
[359-567]
------------------
I
---
F
Q
D
F
S
L
S
I
P
S
G
S
V
T
A
L
V
G
P
S
G
S
G
K
S
T
V
L
S
L
L
L
R
L
Y
D
P
A
S
G
T
I
S
L
D
G
----------------
H
D
--------
I
R
Q
L
N
P
V
W
L
R
-
S
-
K
I
G
T
V
S
Q
E
P
I
L
F
S
C
S
I
A
-
E
N
I
A
Y
G
A
D
D
P
S
S
--
V
T
A
E
E
I
Q
R
V
A
--
E
V
A
----------
N
A
V
A
F
I
R
---
N
F
P
Q
G
FNTVVGEKG
V
L
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
L
K
-
N
P
K
I
L
L
L
D
E
A
T
S
A
L
D
A
---
E
N
E
Y
L
V
-
Q
E
A
L
-
D
R
L
-
M
D
G
R
T
V
L
V
I
A
H
R
L
S
T
I
K
N
-
A
N
M
V
A
V
L
D
Q
-
G
K
I
T
E
Y
G
K
H
E
E
-----------------------