@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : spr1332: (2018-01-09 )
MNTYQLNNGVEIPVLGFGTFKAKDGEEAYRAVLEALKAGYRHIDTAAIYQNEESVGQAIKDSGVPREEMFVTTKLWNSQQTYEQTRQALEKSIEKLGLDYLDLYLIHWPNPKPLRENDAWKTRNAEVWRAMEDLYQEGKIRAIGVSNFLPHHLDALLETATIVPAVNQVRLAPGVYQDQVVAYCREKGILLEAWGPFGQGELFDSKQVQEIAANHGKSVAQIALAWSLAEGFLPLPKSVTTSRIQANLDCFGIELSHEERETLKTIAVQSGAPRVDDVDF
Atome Classification :
(34 SA)
.........10........20........30........40........50........60.-----.......70........80........90........100.......-------110.......120--........130.......140.......150.......160.......170.......180.......190.......---200.----------.---.--......210.......220.......230.......240.......250.......260......-.270....----....280
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
M
N
T
Y
QLNNGVE
I
P
V
L
G
F
G
TFKAK
D
G
E
E
A
Y
R
A
V
L
E
A
L
K
A
G
Y
R
HID
T
A
A
IYQ
N
E
E
S
V
G
Q
A
I
K
DS-----GV
P
R
E
E
M
F
V
T
T
KLWNS
Q
Q
T
Y
E
Q
T
R
Q
A
L
E
K
S
I
E
K
L
G
L
D
Y
L
D
L
Y
L
I
HWP-------NPKPLRENDAWK---TR
N
A
E
V
W
R
A
M
E
D
L
Y
QEG
K
I
R
A
I
G
V
S
NF
L
P
H
H
L
D
A
L
L
E
T
A
T
IVPAV
N
Q
V
RLAPG
V
Y
Q
D
Q
V
V
A
Y
C
R
EK
G
I
L
L
E
AWGPFGQ---G--E----------L---F--
D
S
K
Q
V
Q
E
I
A
A
NHG
K
S
V
A
Q
I
A
L
A
W
S
L
A
E
GFLPLPKSV
T
T
S
R
I
Q
ANL
D
C
F
G
I
ELS
H
E
E
R
E
T
L
K
T
I
AV-QSG-APRV----DDVDF
4
PsiBlast_PDB
93.70
51%
-84
- C8 -
-
3D3F
1
GR_BACSU
A:
[6-260]
-
D
T
V
K
L
H
N
G
V
E
M
P
W
F
G
L
G
V
F
K
V
E
N
G
N
E
A
T
E
S
V
K
A
A
I
K
N
G
Y
R
S
I
D
T
A
A
I
Y
K
N
E
E
G
V
G
I
G
I
K
E
S
-----
G
V
A
R
E
E
L
F
I
T
S
K
V
W
N
E
D
Q
G
Y
E
T
T
L
A
A
F
E
K
S
L
E
R
L
Q
L
D
Y
L
D
L
Y
L
I
H
W
P
-------
G
----------
K
---
D
K
Y
K
D
T
W
R
A
L
E
K
L
Y
K
D
G
K
I
R
A
I
G
V
S
N
F
Q
V
H
H
L
E
E
L
L
K
D
A
E
I
K
P
M
V
N
Q
V
E
F
H
P
R
L
T
Q
K
E
L
R
D
Y
C
K
G
Q
G
I
Q
L
E
A
W
S
P
L
M
Q
---
G
--
Q
----------
L
---
L
--
D
N
E
V
L
T
Q
I
A
E
K
H
N
K
S
V
A
Q
V
I
L
R
W
D
L
Q
H
G
V
V
T
I
P
K
S
I
K
E
H
R
I
I
E
N
A
D
I
F
D
F
E
L
S
Q
E
D
M
D
K
I
D
A
L
--------------------
24
PsiBlast_CBE
92.95
51%
-90
- C8 -
-
3D3F
1
GR_BACSU
B:
[6-260]
-
D
T
V
K
L
H
N
G
V
E
M
P
W
F
G
L
G
V
F
K
V
E
N
G
N
E
A
T
E
S
V
K
A
A
I
K
N
G
Y
R
S
I
D
T
A
A
I
Y
K
N
E
E
G
V
G
I
G
I
K
E
S
-----
G
V
A
R
E
E
L
F
I
T
S
K
V
W
N
E
D
Q
G
Y
E
T
T
L
A
A
F
E
K
S
L
E
R
L
Q
L
D
Y
L
D
L
Y
L
I
H
W
P
-------
G
----------
K
---
D
K
Y
K
D
T
W
R
A
L
E
K
L
Y
K
D
G
K
I
R
A
I
G
V
S
N
F
Q
V
H
H
L
E
E
L
L
K
D
A
E
I
K
P
M
V
N
Q
V
E
F
H
P
R
L
T
Q
K
E
L
R
D
Y
C
K
G
Q
G
I
Q
L
E
A
W
S
P
L
M
Q
---
G
--
Q
----------
L
---
L
--
D
N
E
V
L
T
Q
I
A
E
K
H
N
K
S
V
A
Q
V
I
L
R
W
D
L
Q
H
G
V
V
T
I
P
K
S
I
K
E
H
R
I
I
E
N
A
D
I
F
D
F
E
L
S
Q
E
D
M
D
K
I
D
A
L
--------------------
5
PsiBlast_PDB
92.17
51%
-84
- C8 -
-
3F7J
-
GR_BACSU
A:
[7-261]
-
D
T
V
K
L
H
N
G
V
E
M
P
W
F
G
L
G
V
F
K
V
E
N
G
N
E
A
T
E
S
V
K
A
A
I
K
N
G
Y
R
S
I
D
T
A
A
I
Y
K
N
E
E
G
V
G
I
G
I
K
E
S
-----
G
V
A
R
E
E
L
F
I
T
S
K
V
W
N
E
D
Q
G
Y
E
T
T
L
A
A
F
E
K
S
L
E
R
L
Q
L
D
Y
L
D
L
Y
L
I
H
W
P
-------
G
----------
K
---
D
K
Y
K
D
T
W
R
A
L
E
K
L
Y
K
D
G
K
I
R
A
I
G
V
S
N
F
Q
V
H
H
L
E
E
L
L
K
D
A
E
I
K
P
M
V
N
Q
V
E
F
H
P
R
L
T
Q
K
E
L
R
D
Y
C
K
G
Q
G
I
Q
L
E
A
W
S
P
L
M
Q
---
G
--
Q
----------
L
---
L
--
D
N
E
V
L
T
Q
I
A
E
K
H
N
K
S
V
A
Q
V
I
L
R
W
D
L
Q
H
G
V
V
T
I
P
K
S
I
K
E
H
R
I
I
E
N
A
D
I
F
D
F
E
L
S
Q
E
D
M
D
K
I
D
A
L
--------------------
128
HHSearch
91.62
52%
-79
- C8 -
-
3F7J
-
GR_BACSU
A:
[10-266]
----
K
L
H
N
G
V
E
M
P
W
F
G
L
G
V
F
K
V
E
N
G
N
E
A
T
E
S
V
K
A
A
I
K
N
G
Y
R
S
I
D
T
A
A
I
Y
K
N
E
E
G
V
G
I
G
I
K
E
S
-----
G
V
A
R
E
E
L
F
I
T
S
K
V
W
N
E
D
Q
G
Y
E
T
T
L
A
A
F
E
K
S
L
E
R
L
Q
L
D
Y
L
D
L
Y
L
I
H
W
P
-------
G
K
D
-------------
K
Y
K
D
T
W
R
A
L
E
K
L
Y
K
D
G
K
I
R
A
I
G
V
S
N
F
Q
V
H
H
L
E
E
L
L
K
D
A
E
I
K
P
M
V
N
Q
V
E
F
H
P
R
L
T
Q
K
E
L
R
D
Y
C
K
G
Q
G
I
Q
L
E
A
W
S
P
L
M
Q
---
G
--
Q
----------
L
---
L
--
D
N
E
V
L
T
Q
I
A
E
K
H
N
K
S
V
A
Q
V
I
L
R
W
D
L
Q
H
G
V
V
T
I
P
K
S
I
K
E
H
R
I
I
E
N
A
D
I
F
D
F
E
L
S
Q
E
D
M
D
K
I
D
A
L
N
K
-
D
E
R
--------------
22
PsiBlast_CBE
90.51
47%
-70
- C8 -
-
4G5D
1
PGFS_LEIMA
B:
[15-288]
-----
L
S
N
G
V
K
M
P
Q
F
G
L
G
V
W
Q
S
P
A
G
E
V
T
E
N
A
V
K
W
A
L
C
A
G
Y
R
H
I
D
T
A
A
I
Y
K
N
E
E
S
V
G
A
G
L
R
A
S
-----
G
V
P
R
E
D
V
F
I
T
T
K
L
W
N
T
E
Q
G
Y
E
S
T
L
A
A
F
E
E
S
R
Q
K
L
G
V
D
Y
I
D
L
Y
L
I
H
W
P
-------
R
G
K
D
I
L
S
K
E
G
K
K
---
Y
L
D
S
--
W
R
A
F
E
Q
L
Y
K
E
K
K
V
R
A
I
G
V
S
N
F
H
I
H
H
L
E
D
V
L
A
M
C
T
V
T
P
M
V
N
Q
V
E
L
H
P
L
N
N
Q
A
D
L
R
A
F
C
D
A
K
Q
I
K
V
E
A
W
S
P
L
G
Q
---
G
--
K
----------
L
---
L
--
S
N
P
I
L
S
A
I
G
A
K
Y
N
K
T
A
A
Q
V
I
L
R
W
N
I
Q
K
N
L
I
T
I
P
K
S
V
H
R
E
R
I
E
E
N
A
D
I
F
D
F
E
L
G
A
E
D
V
M
S
I
D
A
L
N
T
-
N
S
R
Y
G
P
D
P
----
D
E
A
Q
F
23
PsiBlast_CBE
90.45
47%
-75
- C8 -
-
4F40
10
PGFS_LEIMA
B:
[15-288]
-----
L
S
N
G
V
K
M
P
Q
F
G
L
G
V
W
Q
S
P
A
G
E
V
T
E
N
A
V
K
W
A
L
C
A
G
Y
R
H
I
D
T
A
A
I
Y
K
N
E
E
S
V
G
A
G
L
R
A
S
-----
G
V
P
R
E
D
V
F
I
T
T
K
L
W
N
T
E
Q
G
Y
E
S
T
L
A
A
F
E
E
S
R
Q
K
L
G
V
D
Y
I
D
L
Y
L
I
H
W
P
-------
R
G
K
D
I
L
S
K
E
G
K
K
---
Y
L
D
S
--
W
R
A
F
E
Q
L
Y
K
E
K
K
V
R
A
I
G
V
S
N
F
H
I
H
H
L
E
D
V
L
A
M
C
T
V
T
P
M
V
N
Q
V
E
L
H
P
L
N
N
Q
A
D
L
R
A
F
C
D
A
K
Q
I
K
V
E
A
W
S
P
L
G
-------
K
----------
L
---
L
--
S
N
P
I
L
S
A
I
G
A
K
Y
N
K
T
A
A
Q
V
I
L
R
W
N
I
Q
K
N
L
I
T
I
P
K
S
V
H
R
E
R
I
E
E
N
A
D
I
F
D
F
E
L
G
A
E
D
V
M
S
I
D
A
L
N
T
-
N
S
R
Y
G
P
D
P
----
D
E
A
Q
F
3
PsiBlast_PDB
90.40
47%
-69
- C8 -
-
4G5D
1
PGFS_LEIMA
A:
[15-288]
-----
L
S
N
G
V
K
M
P
Q
F
G
L
G
V
W
Q
S
P
A
G
E
V
T
E
N
A
V
K
W
A
L
C
A
G
Y
R
H
I
D
T
A
A
I
Y
K
N
E
E
S
V
G
A
G
L
R
A
S
-----
G
V
P
R
E
D
V
F
I
T
T
K
L
W
N
T
E
Q
G
Y
E
S
T
L
A
A
F
E
E
S
R
Q
K
L
G
V
D
Y
I
D
L
Y
L
I
H
W
P
-------
R
G
K
D
I
L
S
K
E
G
K
K
---
Y
L
D
S
--
W
R
A
F
E
Q
L
Y
K
E
K
K
V
R
A
I
G
V
S
N
F
H
I
H
H
L
E
D
V
L
A
M
C
T
V
T
P
M
V
N
Q
V
E
L
H
P
L
N
N
Q
A
D
L
R
A
F
C
D
A
K
Q
I
K
V
E
A
W
S
P
L
G
Q
---
G
--
K
----------
L
---
L
--
S
N
P
I
L
S
A
I
G
A
K
Y
N
K
T
A
A
Q
V
I
L
R
W
N
I
Q
K
N
L
I
T
I
P
K
S
V
H
R
E
R
I
E
E
N
A
D
I
F
D
F
E
L
G
A
E
D
V
M
S
I
D
A
L
N
T
-
N
S
R
Y
G
P
D
P
----
D
E
A
Q
F
117
HHSearch
90.07
49%
-95
- C8 -
-
1VBJ
2
PGFS_TRYBB
A:
[9-268]
T
Q
S
L
K
L
S
N
G
V
M
M
P
V
L
G
F
G
M
W
K
L
Q
D
G
N
E
A
E
T
A
T
M
W
A
I
K
S
G
Y
R
H
I
D
T
A
A
I
Y
K
N
E
E
S
A
G
R
A
I
A
S
C
-----
G
V
P
R
E
E
L
F
V
T
T
K
L
W
N
S
D
Q
G
Y
E
S
T
L
S
A
F
E
K
S
I
K
K
L
G
L
E
Y
V
D
L
Y
L
I
H
W
P
-------
G
K
D
-------------
K
F
I
D
T
W
K
A
F
E
K
L
Y
A
D
K
K
V
R
A
I
G
V
S
N
F
H
E
H
H
I
E
E
L
L
K
H
C
K
V
A
P
M
V
N
Q
I
E
L
H
P
L
L
N
Q
K
A
L
C
E
Y
C
K
S
K
N
I
A
V
T
A
W
S
P
L
G
Q
---
G
--
H
----------
L
---
V
--
E
D
A
R
L
K
A
I
G
G
K
Y
G
K
T
A
A
Q
V
M
L
R
W
E
I
Q
A
G
V
I
T
I
P
K
S
G
N
E
A
R
I
K
E
N
G
N
I
F
D
F
E
L
T
A
E
D
I
Q
V
I
D
G
M
N
A
-
G
H
---------------
2
PsiBlast_PDB
89.92
47%
-71
- C8 -
-
4F40
10
PGFS_LEIMA
A:
[15-288]
-----
L
S
N
G
V
K
M
P
Q
F
G
L
G
V
W
Q
S
P
A
G
E
V
T
E
N
A
V
K
W
A
L
C
A
G
Y
R
H
I
D
T
A
A
I
Y
K
N
E
E
S
V
G
A
G
L
R
A
S
-----
G
V
P
R
E
D
V
F
I
T
T
K
L
W
N
T
E
Q
G
Y
E
S
T
L
A
A
F
E
E
S
R
Q
K
L
G
V
D
Y
I
D
L
Y
L
I
H
W
P
-------
R
G
K
D
I
L
S
K
E
G
K
K
---
Y
L
D
S
--
W
R
A
F
E
Q
L
Y
K
E
K
K
V
R
A
I
G
V
S
N
F
H
I
H
H
L
E
D
V
L
A
M
C
T
V
T
P
M
V
N
Q
V
E
L
H
P
L
N
N
Q
A
D
L
R
A
F
C
D
A
K
Q
I
K
V
E
A
W
S
P
L
G
-------
K
----------
L
---
L
--
S
N
P
I
L
S
A
I
G
A
K
Y
N
K
T
A
A
Q
V
I
L
R
W
N
I
Q
K
N
L
I
T
I
P
K
S
V
H
R
E
R
I
E
E
N
A
D
I
F
D
F
E
L
G
A
E
D
V
M
S
I
D
A
L
N
T
-
N
S
R
Y
G
P
D
P
----
D
E
A
Q
F
122
HHSearch
89.51
47%
-82
- C8 -
-
4G5D
1
PGFS_LEIMA
A:
[13-279]
---
V
T
L
S
N
G
V
K
M
P
Q
F
G
L
G
V
W
Q
S
P
A
G
E
V
T
E
N
A
V
K
W
A
L
C
A
G
Y
R
H
I
D
T
A
A
I
Y
K
N
E
E
S
V
G
A
G
L
R
A
S
-----
G
V
P
R
E
D
V
F
I
T
T
K
L
W
N
T
E
Q
G
Y
E
S
T
L
A
A
F
E
E
S
R
Q
K
L
G
V
D
Y
I
D
L
Y
L
I
H
W
P
-------
R
G
K
D
I
L
S
--
K
E
G
---
K
K
Y
L
D
S
W
R
A
F
E
Q
L
Y
K
E
K
K
V
R
A
I
G
V
S
N
F
H
I
H
H
L
E
D
V
L
A
M
C
T
V
T
P
M
V
N
Q
V
E
L
H
P
L
N
N
Q
A
D
L
R
A
F
C
D
A
K
Q
I
K
V
E
A
W
S
P
L
G
Q
---
G
--
K
----------
L
---
L
--
S
N
P
I
L
S
A
I
G
A
K
Y
N
K
T
A
A
Q
V
I
L
R
W
N
I
Q
K
N
L
I
T
I
P
K
S
V
H
R
E
R
I
E
E
N
A
D
I
F
D
F
E
L
G
A
E
D
V
M
S
I
D
A
L
N
T
-
N
S
R
-
Y
------------
1
PsiBlast_PDB
89.03
49%
-99
- C8 -
-
1VBJ
2
PGFS_TRYBB
A:
[11-261]
--
S
L
K
L
S
N
G
V
M
M
P
V
L
G
F
G
M
W
K
L
Q
D
G
N
E
A
E
T
A
T
M
W
A
I
K
S
G
Y
R
H
I
D
T
A
A
I
Y
K
N
E
E
S
A
G
R
A
I
A
S
C
-----
G
V
P
R
E
E
L
F
V
T
T
K
L
W
N
S
D
Q
G
Y
E
S
T
L
S
A
F
E
K
S
I
K
K
L
G
L
E
Y
V
D
L
Y
L
I
H
W
P
-------
G
----------
K
---
D
K
F
I
D
T
W
K
A
F
E
K
L
Y
A
D
K
K
V
R
A
I
G
V
S
N
F
H
E
H
H
I
E
E
L
L
K
H
C
K
V
A
P
M
V
N
Q
I
E
L
H
P
L
L
N
Q
K
A
L
C
E
Y
C
K
S
K
N
I
A
V
T
A
W
S
P
L
G
Q
---
G
--
H
----------
L
---
V
--
E
D
A
R
L
K
A
I
G
G
K
Y
G
K
T
A
A
Q
V
M
L
R
W
E
I
Q
A
G
V
I
T
I
P
K
S
G
N
E
A
R
I
K
E
N
G
N
I
F
D
F
E
L
T
A
E
D
I
Q
V
I
-----------------------
121
HHSearch
88.85
47%
-86
- C8 -
-
4F40
10
PGFS_LEIMA
B:
[13-279]
---
V
T
L
S
N
G
V
K
M
P
Q
F
G
L
G
V
W
Q
S
P
A
G
E
V
T
E
N
A
V
K
W
A
L
C
A
G
Y
R
H
I
D
T
A
A
I
Y
K
N
E
E
S
V
G
A
G
L
R
A
S
-----
G
V
P
R
E
D
V
F
I
T
T
K
L
W
N
T
E
Q
G
Y
E
S
T
L
A
A
F
E
E
S
R
Q
K
L
G
V
D
Y
I
D
L
Y
L
I
H
W
P
-------
R
G
K
D
I
L
S
--
K
E
G
---
K
K
Y
L
D
S
W
R
A
F
E
Q
L
Y
K
E
K
K
V
R
A
I
G
V
S
N
F
H
I
H
H
L
E
D
V
L
A
M
C
T
V
T
P
M
V
N
Q
V
E
L
H
P
L
N
N
Q
A
D
L
R
A
F
C
D
A
K
Q
I
K
V
E
A
W
S
P
L
G
-------
K
----------
L
---
L
--
S
N
P
I
L
S
A
I
G
A
K
Y
N
K
T
A
A
Q
V
I
L
R
W
N
I
Q
K
N
L
I
T
I
P
K
S
V
H
R
E
R
I
E
E
N
A
D
I
F
D
F
E
L
G
A
E
D
V
M
S
I
D
A
L
N
T
-
N
S
R
-
Y
------------
124
HHSearch
88.37
48%
-62
- C8 -
-
4GIE
1
PGFS_TRYCC
A:
[14-275]
-
N
C
V
T
L
H
N
S
V
R
M
P
Q
L
G
L
G
V
W
R
A
Q
D
G
A
E
T
A
N
A
V
R
W
A
I
E
A
G
Y
R
H
I
D
T
A
Y
I
Y
S
N
E
R
G
V
G
Q
G
I
R
E
S
-----
G
V
P
R
E
E
V
W
V
T
T
K
V
W
N
S
D
Q
G
Y
E
K
T
L
A
A
F
E
R
S
R
E
L
L
G
L
E
Y
I
D
L
Y
L
I
H
W
P
-------
G
K
K
-------------
K
F
V
D
T
W
K
A
L
E
K
L
Y
E
E
K
K
V
R
A
I
G
V
S
N
F
E
P
H
H
L
T
E
L
F
K
S
C
K
I
R
P
M
V
N
Q
V
E
L
H
P
L
F
Q
Q
R
T
L
R
E
F
C
K
Q
H
N
I
A
I
T
A
W
S
P
L
G
S
---
G
--
E
----------
E
AGI
L
--
K
N
H
V
L
G
E
I
A
K
K
H
N
K
S
P
A
Q
V
V
I
R
W
D
I
Q
H
G
I
V
T
I
P
K
S
T
N
K
G
R
I
Q
E
N
F
N
V
W
D
F
K
L
T
E
E
E
M
R
Q
I
D
E
L
N
E
-
D
K
---------------
115
HHSearch
87.78
44%
-62
- C8 -
-
4MHB
-
?
A:
[15-282]
M
Q
T
V
K
L
N
N
G
I
A
M
P
L
L
G
F
G
V
F
Q
M
T
N
T
A
E
C
E
R
A
V
I
D
A
I
E
T
G
Y
R
L
I
D
T
A
A
S
Y
Q
N
E
T
Q
V
G
N
A
L
K
L
S
-----
G
I
A
R
D
E
L
F
I
T
T
K
L
W
L
Q
D
T
Y
Y
E
G
A
K
A
Q
F
E
R
S
L
N
R
L
Q
L
D
Y
V
D
L
Y
L
I
H
Q
P
-------
Y
G
D
--------------
V
H
G
A
W
R
A
M
E
E
L
H
Q
A
G
K
I
R
A
I
G
V
S
N
F
H
P
D
R
L
A
D
L
M
A
F
N
K
I
I
P
A
V
N
Q
I
E
V
N
P
F
N
Q
Q
L
H
A
V
P
W
M
Q
S
R
G
I
Q
P
E
A
W
A
P
F
A
E
---
G
--
R
NG--------
L
---
F
--
Q
N
P
V
L
T
A
I
G
E
K
Y
G
K
S
V
G
Q
V
V
L
R
W
I
F
Q
R
G
I
V
S
L
A
K
S
V
R
K
G
R
M
E
E
N
I
N
I
L
D
F
E
L
S
A
E
D
M
L
Q
I
A
A
L
D
T
-
A
T
S
-
A
F
F
S
----
H
R
---
114
HHSearch
87.74
44%
-64
- C8 -
-
4MHB
-
?
E:
[15-282]
M
Q
T
V
K
L
N
N
G
I
A
M
P
L
L
G
F
G
V
F
-
M
T
N
T
A
E
C
E
R
A
V
I
D
A
I
E
T
G
Y
R
L
I
D
T
A
A
S
Y
Q
N
E
T
Q
V
G
N
A
L
K
L
S
-----
G
I
A
R
D
E
L
F
I
T
T
K
L
W
L
Q
D
T
Y
Y
E
G
A
K
A
Q
F
E
R
S
L
N
R
L
Q
L
D
Y
V
D
L
Y
L
I
H
Q
P
-------
Y
G
D
--------------
V
H
G
A
W
R
A
M
E
E
L
H
Q
A
G
K
I
R
A
I
G
V
S
N
F
H
P
D
R
L
A
D
L
M
A
F
N
K
I
I
P
A
V
N
Q
I
E
V
N
P
F
N
Q
Q
L
H
A
V
P
W
M
Q
S
R
G
I
Q
P
E
A
W
A
P
F
A
E
---
G
--
R
NG--------
L
---
F
--
Q
N
P
V
L
T
A
I
G
E
K
Y
G
K
S
V
G
Q
V
V
L
R
W
I
F
Q
R
G
I
V
S
L
A
K
S
V
R
K
G
R
M
E
E
N
I
N
I
L
D
F
E
L
S
A
E
D
M
L
Q
I
A
A
L
D
T
-
A
T
S
-
A
F
F
S
----
H
R
---
21
PsiBlast_CBE
87.66
49%
-93
- C8 -
-
1VBJ
2
PGFS_TRYBB
B:
[11-261]
--
S
L
K
L
S
N
G
V
M
M
P
V
L
G
F
G
M
W
K
L
Q
D
G
N
E
A
E
T
A
T
M
W
A
I
K
S
G
Y
R
H
I
D
T
A
A
I
Y
K
N
E
E
S
A
G
R
A
I
A
S
C
-----
G
V
P
R
E
E
L
F
V
T
T
K
L
W
N
S
D
Q
G
Y
E
S
T
L
S
A
F
E
K
S
I
K
K
L
G
L
E
Y
V
D
L
Y
L
I
H
W
P
-------
G
----------
K
---
D
K
F
I
D
T
W
K
A
F
E
K
L
Y
A
D
K
K
V
R
A
I
G
V
S
N
F
H
E
H
H
I
E
E
L
L
K
H
C
K
V
A
P
M
V
N
Q
I
E
L
H
P
L
L
N
Q
K
A
L
C
E
Y
C
K
S
K
N
I
A
V
T
A
W
S
P
L
G
Q
---
G
--
H
----------
L
---
V
--
E
D
A
R
L
K
A
I
G
G
K
Y
G
K
T
A
A
Q
V
M
L
R
W
E
I
Q
A
G
V
I
T
I
P
K
S
G
N
E
A
R
I
K
E
N
G
N
I
F
D
F
E
L
T
A
E
D
I
Q
V
I
-----------------------
8
PsiBlast_PDB
87.49
44%
-65
- C8 -
-
4Q3M
-
?
A:
[2-274]
-
H
S
V
K
L
N
N
N
Y
E
M
P
I
I
G
L
G
T
F
R
S
K
K
N
D
-
A
Y
N
A
V
K
A
A
L
E
G
G
Y
R
H
I
D
T
A
M
I
Y
G
N
E
E
E
V
G
R
A
I
K
D
S
-----
N
I
P
R
E
E
I
F
V
T
T
K
L
W
N
T
D
Q
G
Y
E
K
T
L
E
A
F
N
T
S
L
K
N
L
G
L
D
Y
I
D
L
Y
L
I
H
W
F
-------
K
G
Y
----
D
N
A
L
S
---
T
-----
Y
R
A
F
E
T
L
Y
E
E
G
K
V
K
A
I
G
V
S
N
F
N
V
H
H
L
M
Y
L
M
E
N
A
K
I
P
P
M
V
N
Q
V
E
T
H
V
T
L
Q
N
H
F
L
H
D
Y
C
K
K
N
N
I
Q
L
E
A
Y
A
P
L
M
S
HQ
I
K
--
D
----------
L
---
L
--
S
N
E
T
M
A
K
I
A
K
K
H
D
K
T
I
P
Q
I
A
I
R
W
L
I
E
R
E
I
V
V
I
P
K
S
I
T
P
E
R
I
V
Q
N
F
D
V
F
D
F
T
L
D
E
E
D
M
K
S
I
R
S
V
N
T
G
K
K
I
-
F
T
E
F
----
D
N
V
D
Y
26
PsiBlast_CBE
87.44
47%
-99
- C8 -
-
4FZI
1
PGFS_TRYCC
B:
[14-264]
-
N
C
V
T
L
H
N
S
V
R
M
P
Q
L
G
L
G
V
W
R
A
Q
D
G
A
E
T
A
N
A
V
R
W
A
I
E
A
G
Y
R
H
I
D
T
A
Y
I
Y
S
N
E
R
G
V
G
Q
G
I
R
E
S
-----
G
V
P
R
E
E
V
W
V
T
T
K
V
W
N
S
D
Q
G
Y
E
K
T
L
A
A
F
E
R
S
R
E
L
L
G
L
E
Y
I
D
L
Y
L
I
H
W
P
-------
G
K
K
K
F
-------------
V
D
T
W
K
A
L
E
K
L
Y
E
E
K
K
V
R
A
I
G
V
S
N
F
E
P
H
H
L
T
E
L
F
K
S
C
K
I
R
P
M
V
N
Q
V
E
L
H
P
L
F
Q
Q
R
T
L
R
E
F
C
K
Q
H
N
I
A
I
T
A
W
S
P
L
G
S
-----------------
I
---
L
--
K
N
H
V
L
G
E
I
A
K
K
H
N
K
S
P
A
Q
V
V
I
R
W
D
I
Q
H
G
I
V
T
I
P
K
S
T
N
K
G
R
I
Q
E
N
F
N
V
W
D
F
K
L
T
E
E
E
---------------------------
134
HHSearch
87.17
46%
-92
- C8 -
-
3O0K
4
?
B:
[26-282]
V
P
T
V
K
L
N
D
G
N
H
I
P
Q
L
G
Y
G
V
W
Q
I
S
N
-
D
E
A
V
S
A
V
S
E
A
L
K
A
G
Y
R
H
I
D
T
A
T
I
Y
G
N
E
E
G
V
G
K
A
I
N
G
S
-----
G
I
A
R
A
D
I
F
L
T
T
K
L
W
N
S
D
Q
G
Y
E
S
T
L
K
A
F
D
T
S
L
K
K
L
G
T
D
Y
V
D
L
Y
L
I
H
W
P
-------
M
P
S
K
D
-----------
L
F
M
E
T
W
R
A
F
I
K
L
K
E
E
G
R
V
K
S
I
G
V
S
N
F
R
T
A
D
L
E
R
L
I
K
E
S
G
V
T
P
V
L
N
Q
I
E
L
H
P
Q
F
Q
Q
D
E
L
R
L
F
H
G
K
H
D
I
A
T
E
A
W
S
P
L
G
------------------
L
---
L
--
E
D
P
T
L
K
S
I
A
E
K
H
A
K
S
V
A
Q
I
I
L
R
W
H
I
E
T
G
N
I
V
I
P
K
S
I
T
P
A
R
I
K
E
N
F
D
I
F
D
F
T
L
N
G
T
D
H
D
A
I
T
K
L
--------------------
125
HHSearch
86.79
41%
-97
- C8 -
-
2WZM
1
Y2407_MYCS2
B:
[11-274]
I
P
T
V
T
L
N
D
D
N
T
L
P
V
V
G
I
G
V
G
E
L
S
D
-
S
E
A
E
R
S
V
S
A
A
L
E
A
G
Y
R
L
I
D
T
A
A
A
Y
G
N
E
A
A
V
G
R
A
I
A
A
S
-----
G
I
P
R
D
E
I
Y
V
T
T
K
L
A
T
P
D
Q
G
F
T
S
S
Q
A
A
A
R
A
S
L
E
R
L
G
L
D
Y
V
D
L
Y
L
I
H
W
P
-------
G
G
D
T
-----------
S
K
Y
V
D
S
W
G
G
L
M
K
V
K
E
D
G
I
A
R
S
I
G
V
C
N
F
G
A
E
D
L
E
T
I
V
S
L
T
Y
F
T
P
A
V
N
Q
I
E
L
H
P
L
L
N
Q
A
A
L
R
E
V
N
A
G
Y
N
I
V
T
E
A
Y
G
P
L
G
V
---
G
--
R
----------
L
---
L
--
D
H
P
A
V
T
A
I
A
E
A
H
G
R
T
A
A
Q
V
L
L
R
W
S
I
Q
L
G
N
V
V
I
S
R
S
A
N
P
E
R
I
A
S
N
L
D
V
F
G
F
E
L
T
A
D
E
M
E
T
L
N
G
L
D
D
-
G
T
R
-
F
R
-----------
7
PsiBlast_PDB
86.58
47%
-73
- C8 -
-
4GIE
1
PGFS_TRYCC
A:
[14-264]
-
N
C
V
T
L
H
N
S
V
R
M
P
Q
L
G
L
G
V
W
R
A
Q
D
G
A
E
T
A
N
A
V
R
W
A
I
E
A
G
Y
R
H
I
D
T
A
Y
I
Y
S
N
E
R
G
V
G
Q
G
I
R
E
S
-----
G
V
P
R
E
E
V
W
V
T
T
K
V
W
N
S
D
Q
G
Y
E
K
T
L
A
A
F
E
R
S
R
E
L
L
G
L
E
Y
I
D
L
Y
L
I
H
W
P
-------
G
K
K
K
F
-------------
V
D
T
W
K
A
L
E
K
L
Y
E
E
K
K
V
R
A
I
G
V
S
N
F
E
P
H
H
L
T
E
L
F
K
S
C
K
I
R
P
M
V
N
Q
V
E
L
H
P
L
F
Q
Q
R
T
L
R
E
F
C
K
Q
H
N
I
A
I
T
A
W
S
P
L
G
S
---
G
--
E
EAG-------
I
---
L
--
K
N
H
V
L
G
E
I
A
K
K
H
N
K
S
P
A
Q
V
V
I
R
W
D
I
Q
H
G
I
V
T
I
P
K
S
T
N
K
G
R
I
Q
E
N
F
N
V
W
D
F
K
L
T
E
E
E
---------------------------
33
PsiBlast_CBE
85.72
45%
-88
- C8 -
-
3O0K
3
?
C:
[28-279]
--
T
V
K
L
N
D
G
N
H
I
P
Q
L
G
Y
G
V
W
Q
I
S
N
-
D
E
A
V
S
A
V
S
E
A
L
K
A
G
Y
R
H
I
D
T
A
T
I
Y
G
N
E
E
G
V
G
K
A
I
N
G
S
-----
G
I
A
R
A
D
I
F
L
T
T
K
L
W
N
S
D
Q
G
Y
E
S
T
L
K
A
F
D
T
S
L
K
K
L
G
T
D
Y
V
D
L
Y
L
I
H
W
P
-------
M
P
S
--------
K
---
D
L
F
M
E
T
W
R
A
F
I
K
L
K
E
E
G
R
V
K
S
I
G
V
S
N
F
R
T
A
D
L
E
R
L
I
K
E
S
G
V
T
P
V
L
N
Q
I
E
L
H
P
Q
F
Q
Q
D
E
L
R
L
F
H
G
K
H
D
I
A
T
E
A
W
S
P
L
G
------------------
L
---
L
--
E
D
P
T
L
K
S
I
A
E
K
H
A
K
S
V
A
Q
I
I
L
R
W
H
I
E
T
G
N
I
V
I
P
K
S
I
T
P
A
R
I
K
E
N
F
D
I
F
D
F
T
L
N
G
T
D
H
D
A
I
-----------------------
6
PsiBlast_PDB
85.52
47%
-71
- C8 -
-
4FZI
1
PGFS_TRYCC
A:
[14-264]
-
N
C
V
T
L
H
N
S
V
R
M
P
Q
L
G
L
G
V
W
R
A
Q
D
G
A
E
T
A
N
A
V
R
W
A
I
E
A
G
Y
R
H
I
D
T
A
Y
I
Y
S
N
E
R
G
V
G
Q
G
I
R
E
S
-----
G
V
P
R
E
E
V
W
V
T
T
K
V
W
N
S
D
Q
G
Y
E
K
T
L
A
A
F
E
R
S
R
E
L
L
G
L
E
Y
I
D
L
Y
L
I
H
W
P
-------
G
K
K
K
F
-------------
V
D
T
W
K
A
L
E
K
L
Y
E
E
K
K
V
R
A
I
G
V
S
N
F
E
P
H
H
L
T
E
L
F
K
S
C
K
I
R
P
M
V
N
Q
V
E
L
H
P
L
F
Q
Q
R
T
L
R
E
F
C
K
Q
H
N
I
A
I
T
A
W
S
P
L
G
S
---
G
--
E
EAG-------
I
---
L
--
K
N
H
V
L
G
E
I
A
K
K
H
N
K
S
P
A
Q
V
V
I
R
W
D
I
Q
H
G
I
V
T
I
P
K
S
T
N
K
G
R
I
Q
E
N
F
N
V
W
D
F
K
L
T
E
E
E
---------------------------
9
PsiBlast_PDB
84.97
45%
-87
- C8 -
-
3O0K
4
?
A:
[28-279]
--
T
V
K
L
N
D
G
N
H
I
P
Q
L
G
Y
G
V
W
Q
I
S
N
-
D
E
A
V
S
A
V
S
E
A
L
K
A
G
Y
R
H
I
D
T
A
T
I
Y
G
N
E
E
G
V
G
K
A
I
N
G
S
-----
G
I
A
R
A
D
I
F
L
T
T
K
L
W
N
S
D
Q
G
Y
E
S
T
L
K
A
F
D
T
S
L
K
K
L
G
T
D
Y
V
D
L
Y
L
I
H
W
P
-------
M
P
S
--------
K
---
D
L
F
M
E
T
W
R
A
F
I
K
L
K
E
E
G
R
V
K
S
I
G
V
S
N
F
R
T
A
D
L
E
R
L
I
K
E
S
G
V
T
P
V
L
N
Q
I
E
L
H
P
Q
F
Q
Q
D
E
L
R
L
F
H
G
K
H
D
I
A
T
E
A
W
S
P
L
G
Q
---
G
-------------
L
---
L
--
E
D
P
T
L
K
S
I
A
E
K
H
A
K
S
V
A
Q
I
I
L
R
W
H
I
E
T
G
N
I
V
I
P
K
S
I
T
P
A
R
I
K
E
N
F
D
I
F
D
F
T
L
N
G
T
D
H
D
A
I
-----------------------
34
PsiBlast_CBE
84.55
45%
-90
- C8 -
-
3O0K
4
?
B:
[28-279]
--
T
V
K
L
N
D
G
N
H
I
P
Q
L
G
Y
G
V
W
Q
I
S
N
-
D
E
A
V
S
A
V
S
E
A
L
K
A
G
Y
R
H
I
D
T
A
T
I
Y
G
N
E
E
G
V
G
K
A
I
N
G
S
-----
G
I
A
R
A
D
I
F
L
T
T
K
L
W
N
S
D
Q
G
Y
E
S
T
L
K
A
F
D
T
S
L
K
K
L
G
T
D
Y
V
D
L
Y
L
I
H
W
P
-------
M
P
S
--------
K
---
D
L
F
M
E
T
W
R
A
F
I
K
L
K
E
E
G
R
V
K
S
I
G
V
S
N
F
R
T
A
D
L
E
R
L
I
K
E
S
G
V
T
P
V
L
N
Q
I
E
L
H
P
Q
F
Q
Q
D
E
L
R
L
F
H
G
K
H
D
I
A
T
E
A
W
S
P
L
G
------------------
L
---
L
--
E
D
P
T
L
K
S
I
A
E
K
H
A
K
S
V
A
Q
I
I
L
R
W
H
I
E
T
G
N
I
V
I
P
K
S
I
T
P
A
R
I
K
E
N
F
D
I
F
D
F
T
L
N
G
T
D
H
D
A
I
-----------------------
32
PsiBlast_CBE
84.44
45%
-86
- C8 -
-
3O0K
3
?
D:
[28-279]
--
T
V
K
L
N
D
G
N
H
I
P
Q
L
G
Y
G
V
W
Q
I
S
N
-
D
E
A
V
S
A
V
S
E
A
L
K
A
G
Y
R
H
I
D
T
A
T
I
Y
G
N
E
E
G
V
G
K
A
I
N
G
S
-----
G
I
A
R
A
D
I
F
L
T
T
K
L
W
N
S
D
Q
G
Y
E
S
T
L
K
A
F
D
T
S
L
K
K
L
G
T
D
Y
V
D
L
Y
L
I
H
W
P
-------
M
P
S
--------
K
---
D
L
F
M
E
T
W
R
A
F
I
K
L
K
E
E
G
R
V
K
S
I
G
V
S
N
F
R
T
A
D
L
E
R
L
I
K
E
S
G
V
T
P
V
L
N
Q
I
E
L
H
P
Q
F
Q
Q
D
E
L
R
L
F
H
G
K
H
D
I
A
T
E
A
W
S
P
L
G
-------
K
----------
L
---
L
--
E
D
P
T
L
K
S
I
A
E
K
H
A
K
S
V
A
Q
I
I
L
R
W
H
I
E
T
G
N
I
V
I
P
K
S
I
T
P
A
R
I
K
E
N
F
D
I
F
D
F
T
L
N
G
T
D
H
D
A
I
-----------------------
120
HHSearch
83.26
43%
-54
- C8 -
-
1A80
1
DKGA_CORSC
A:
[3-269]
-
P
S
I
V
L
N
D
G
N
S
I
P
Q
L
G
Y
G
V
F
K
V
P
P
-
A
D
T
Q
R
A
V
E
E
A
L
E
V
G
Y
R
H
I
D
T
A
A
I
Y
G
N
E
E
G
V
G
A
A
I
A
A
S
-----
G
I
A
R
D
D
L
F
I
T
T
K
L
W
N
D
R
H
D
G
D
E
P
A
A
A
I
A
E
S
L
A
K
L
A
L
D
Q
V
D
L
Y
L
V
H
W
P
-------
T
P
A
A
-----------
D
N
Y
V
H
A
W
E
K
M
I
E
L
R
A
A
G
L
T
R
S
I
G
V
S
N
H
L
V
P
H
L
E
R
I
V
A
A
T
G
V
V
P
A
V
N
Q
I
E
L
H
P
A
Y
Q
Q
R
E
I
T
D
W
A
A
A
H
D
V
K
I
E
S
W
G
P
L
G
Q
---
G
--
K
----------
Y
---
D
LF
G
A
E
P
V
T
A
A
A
A
A
H
G
K
T
P
A
Q
A
V
L
R
W
H
L
Q
K
G
F
V
V
F
P
K
S
V
R
R
E
R
L
E
E
N
L
D
V
F
D
F
D
L
T
D
T
E
I
A
A
I
D
A
M
D
P
-
G
D
G
-
S
G
R
V
---------
15
PsiBlast_PDB
82.96
42%
-51
- C8 -
-
1A80
1
DKGA_CORSC
A:
[7-277]
-----
L
N
D
G
N
S
I
P
Q
L
G
Y
G
V
F
K
V
P
P
A
D
-
T
Q
R
A
V
E
E
A
L
E
V
G
Y
R
H
I
D
T
A
A
I
Y
G
N
E
E
G
V
G
A
A
I
A
A
S
-----
G
I
A
R
D
D
L
F
I
T
T
K
L
W
N
D
R
H
D
G
D
E
P
A
A
A
I
A
E
S
L
A
K
L
A
L
D
Q
V
D
L
Y
L
V
H
W
P
-------
T
P
A
--------
A
---
D
N
Y
V
H
A
W
E
K
M
I
E
L
R
A
A
G
L
T
R
S
I
G
V
S
N
H
L
V
P
H
L
E
R
I
V
A
A
T
G
V
V
P
A
V
N
Q
I
E
L
H
P
A
Y
Q
Q
R
E
I
T
D
W
A
A
A
H
D
V
K
I
E
S
W
G
P
L
G
Q
---
G
KY
D
----------
L
---
F
--
G
A
E
P
V
T
A
A
A
A
A
H
G
K
T
P
A
Q
A
V
L
R
W
H
L
Q
K
G
F
V
V
F
P
K
S
V
R
R
E
R
L
E
E
N
L
D
V
F
D
F
D
L
T
D
T
E
I
A
A
I
D
A
M
D
P
-
G
D
G
-
S
G
R
V
SAHP
D
E
V
D
-
18
PsiBlast_PDB
81.38
41%
-51
- C8 -
-
1M9H
1
DKGA_CORSC
A:
[8-278]
-----
L
N
D
G
N
S
I
P
Q
L
G
Y
G
V
Y
K
V
P
P
A
D
-
T
Q
R
A
V
E
E
A
L
E
V
G
Y
R
H
I
D
T
A
A
I
Y
G
N
E
E
G
V
G
A
A
I
A
A
S
-----
G
I
A
R
D
D
L
F
I
T
T
K
L
W
N
D
R
H
D
G
D
E
P
A
A
A
I
A
E
S
L
A
K
L
A
L
D
Q
V
D
L
Y
L
V
H
W
P
-------
T
P
A
--------
A
---
D
N
Y
V
H
A
W
E
K
M
I
E
L
R
A
A
G
L
T
R
S
I
G
V
S
N
H
L
V
P
H
L
E
R
I
V
A
A
T
G
V
V
P
A
V
N
Q
I
E
L
H
P
A
Y
Q
Q
R
E
I
T
D
W
A
A
A
H
D
V
K
I
E
S
W
G
P
L
G
Q
---
G
KY
D
----------
L
---
F
--
G
A
E
P
V
T
A
A
A
A
A
H
G
K
T
P
A
Q
A
V
L
R
W
H
L
Q
K
G
F
V
V
F
P
G
S
V
R
R
E
H
L
E
E
N
L
D
V
F
D
F
D
L
T
D
T
E
I
A
A
I
D
A
M
D
P
-
G
D
G
-
S
G
R
V
SGHP
D
E
V
D
-
13
PsiBlast_PDB
79.86
42%
-58
- C8 -
-
1MZR
2
DKGA_ECOLI
A:
[29-274]
----
K
L
Q
D
G
N
V
M
P
Q
L
G
L
G
V
W
Q
A
S
N
-
E
E
V
I
T
A
I
Q
K
A
L
E
V
G
Y
R
S
I
D
T
A
A
A
Y
K
N
E
E
G
V
G
K
A
L
K
N
A
-----
S
V
N
R
E
E
L
F
I
T
T
K
L
W
N
D
D
--
H
K
R
P
R
E
A
L
L
D
S
L
K
K
L
Q
L
D
Y
I
D
L
Y
L
M
H
W
P
-------
V
P
A
--------
I
---
D
H
Y
V
E
A
W
K
G
M
I
E
L
Q
K
E
G
L
I
K
S
I
G
V
C
N
F
Q
I
H
H
L
Q
R
L
I
D
E
T
G
V
T
P
V
I
N
Q
I
E
L
H
P
L
M
Q
Q
R
Q
L
H
A
W
N
A
T
H
K
I
Q
T
E
S
W
S
P
L
A
Q
---
G
GK
G
----------
V
---
F
--
D
Q
K
V
I
R
D
L
A
D
K
Y
G
K
T
P
A
Q
I
V
I
R
W
H
L
D
S
G
L
V
V
I
P
K
S
V
T
P
S
R
I
A
E
N
F
D
V
W
D
F
R
L
D
K
D
E
---------------------------
43
PsiBlast_CBE
75.21
37%
10
- C8 -
-
3CV7
2
AK1A1_PIG
A:
[8-295]
-----
L
H
T
G
Q
K
M
P
L
I
G
L
G
T
W
K
S
E
P
G
Q
-
V
K
A
A
I
K
Y
A
L
T
V
G
Y
R
H
I
D
C
A
A
I
Y
G
N
E
L
E
I
G
E
A
L
Q
E
T
VGPGK
A
V
P
R
E
E
L
F
V
T
S
K
L
W
N
T
K
H
H
P
E
D
V
E
P
A
L
R
K
T
L
A
D
L
Q
L
E
Y
L
D
L
Y
L
M
H
W
P
Y
A
F
ERGD
N
P
F
P
K
N
A
D
G
T
I
R
Y
D
A
T
H
Y
K
D
T
W
K
A
L
E
A
L
V
A
K
G
L
V
R
A
L
G
L
S
N
F
S
S
R
Q
I
D
D
V
L
S
V
A
S
V
R
P
A
V
L
Q
V
E
C
H
P
Y
L
A
Q
N
E
L
I
A
H
C
Q
A
R
G
L
E
V
T
A
Y
S
P
L
G
S
---
S
--
D
RAWRDPNEPV
L
---
L
--
E
E
P
V
V
Q
A
L
A
E
K
Y
N
R
S
P
A
Q
I
L
L
R
W
Q
V
Q
R
K
V
I
C
I
P
K
S
V
T
P
S
R
I
L
Q
N
I
Q
V
F
D
F
T
F
S
P
E
E
M
K
Q
L
D
A
L
--------------------
20
PsiBlast_PDB
72.97
37%
9
- C8 -
-
4GAC
1
AK1A1_MOUSE
A:
[7-291]
-----
L
H
T
G
Q
K
M
P
L
I
G
L
G
T
W
K
S
E
P
G
Q
-
V
K
A
A
I
K
H
A
L
S
A
G
Y
R
H
I
D
C
A
S
V
Y
G
N
E
T
E
I
G
E
A
L
K
E
S
VGSGK
A
V
P
R
E
E
L
F
V
T
S
K
L
W
N
T
K
H
H
P
E
D
V
E
P
A
L
R
K
T
L
A
D
L
Q
L
E
Y
L
D
L
Y
L
M
H
W
P
Y
A
F
ERGD
N
P
F
P
K
N
A
D
G
T
V
R
Y
D
S
T
H
Y
K
E
T
W
K
A
L
E
V
L
V
A
K
G
L
V
K
A
L
G
L
S
N
F
N
S
R
Q
I
D
D
V
L
S
V
A
S
V
R
P
A
V
L
Q
V
E
C
H
P
Y
L
A
Q
N
E
L
I
A
H
C
H
A
R
G
L
E
V
T
A
Y
S
P
L
G
S
---
S
--
D
RAWRHPDEPV
L
---
L
--
E
E
P
V
V
L
A
L
A
E
K
H
G
R
S
P
A
Q
I
L
L
R
W
Q
V
Q
R
K
V
I
C
I
P
K
S
I
N
P
S
R
I
L
Q
N
I
Q
V
F
D
F
T
F
S
P
E
E
M
K
Q
L
D
A
L
--------------------
45
PsiBlast_CBE
70.33
37%
-
- C8 -
-
1CWN
1
AK1A1_PIG
A:
[7-291]
-----
L
H
T
G
Q
K
M
P
L
I
G
L
G
T
W
K
S
E
P
G
Q
-
V
K
A
A
I
K
Y
A
L
T
V
G
Y
R
H
I
D
C
A
A
I
Y
G
N
E
L
E
I
G
E
A
L
T
E
T
VGPGK
A
V
P
R
E
E
L
F
V
T
S
K
L
W
N
T
K
H
H
P
E
D
V
E
P
A
L
R
K
T
L
A
D
L
Q
L
E
Y
L
D
L
Y
L
M
H
W
P
Y
A
F
ERGD
N
P
F
P
K
N
A
D
G
T
I
R
Y
D
A
T
H
Y
K
D
T
W
K
A
L
E
A
L
V
A
K
G
L
V
R
A
L
G
L
S
N
F
S
S
R
Q
I
D
D
V
L
S
V
A
S
V
R
P
A
V
L
Q
V
E
C
H
P
Y
L
A
Q
N
E
L
I
A
H
C
Q
A
R
G
L
E
V
T
A
Y
S
P
L
G
S
---
S
--
D
RAWRDPNEPV
L
---
L
--
E
E
P
V
V
Q
A
L
A
E
K
Y
N
R
S
P
A
Q
I
L
L
R
W
Q
V
Q
R
K
V
I
C
I
P
K
S
V
T
P
S
R
I
P
Q
N
I
Q
V
F
D
F
T
F
S
P
E
E
M
K
Q
L
D
A
L
--------------------
44
PsiBlast_CBE
70.30
37%
-
- C8 -
-
1AE4
1
AK1A1_PIG
A:
[8-292]
-----
L
H
T
G
Q
K
M
P
L
I
G
L
G
T
W
K
S
E
P
G
Q
-
V
K
A
A
I
K
Y
A
L
T
V
G
Y
R
H
I
D
C
A
A
I
Y
G
N
E
L
E
I
G
E
A
L
T
E
T
VGPGK
A
V
P
R
E
E
L
F
V
T
S
K
L
W
N
T
K
H
H
P
E
D
V
E
P
A
L
R
K
T
L
A
D
L
Q
L
E
Y
L
D
L
Y
L
M
H
W
P
Y
A
F
ERGD
N
P
F
P
K
N
A
D
G
T
I
R
YDA
T
H
Y
K
D
T
W
K
A
L
E
A
L
V
A
K
G
L
V
R
A
L
G
L
S
N
F
S
S
R
Q
I
D
D
V
L
S
V
A
S
V
R
P
A
V
L
Q
V
E
C
H
P
Y
L
A
Q
N
E
L
I
A
H
C
Q
A
R
G
L
E
V
T
A
Y
S
P
L
G
S
---
S
--
D
RAWRDPNEPV
L
---
L
--
E
E
P
V
V
Q
A
L
A
E
K
Y
N
R
S
P
A
Q
I
L
L
R
W
Q
V
Q
R
K
V
I
C
I
P
K
S
V
T
P
S
R
I
P
Q
N
I
Q
V
F
D
F
T
F
S
P
E
E
M
K
Q
L
D
A
L
--------------------