@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : spr1333: (2018-01-10 )
MNKSRLGRGRHGKTRHVLLALIGILAISICLLGGFIAFKIYQQKSFEQKIESLKKEKDDQLSEGNQKEHFRQGQAEVIAYYPLQGEKVISSVRELINQDVKDKLESKDNLVFYYTEQEESGLKGVVNRNVTKQIYDLVAFKIEETEKTSLGKVHLTEDGQPFTLDQLFSDASKAKEQLIKELTSFIEDKKIEQDQSEQIVKNFSDQDLSAWNFDYKDSQIILYPSPVVENLEEIALPVSAFFDVIQSSYLLEKDAALYQSYFDKKHQKVVALTFDDGPNPATTPQVLETLAKYDIKATFFVLGKNVSGNEDLVKRIKSEGHVVGNHSWSHPILSQLSLDEAKKQITDTEDVLTKVLGSSSKLMRPPYGAITDDIRNSLDLSFIMWDVDSLDWKSKNEASILTEIQHQVANGSIVLMHDIHSPTVNALPRVIEYLKNQGYTFVTIPEMLNTRLKAHELYYSRDE
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70........80........90........100...-.-...110.......120.......130.....-..140--.........150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.....-.-.-310.......320.......330....------...340.......350.......-360--.-.....---..370.---.---..-------------..---.---380.......390-...--..-.---.400.-----...----..--.----------------410.........420--....--...-.430.......440.......450.......460.
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
M
N
K
S
RLGRGRHG
K
T
R
H
V
L
L
A
L
I
G
I
L
A
I
S
I
C
L
L
G
G
F
I
A
F
K
I
Y
Q
Q
K
S
F
E
Q
K
I
E
S
L
K
K
EKDDQLSEG
N
Q
K
E
H
F
RQGQ
A
E
V
I
A
Y
YPLQ
G
E
K
V
I
S
S
V
R
E
L
I
N
Q
D
V
K
D
K
LE-S-KD
N
L
V
F
Y
Y
TEQEESG
L
K
G
V
V
N
R
N
V
T
K
Q
I
Y
D
L
-
V
A
F
----
K
I
EETEKTSL
G
K
V
H
LTEDGQP
F
T
L
D
Q
L
F
S
D
A
S
K
A
K
E
Q
L
I
K
E
L
T
S
F
I
E
DKKIE
Q
D
Q
S
E
Q
I
V
K
NFSDQDLSAWNFDYKD
S
Q
I
I
LYP
S
P
V
V
E
N
L
E
E
IA
L
P
V
S
A
F
F
D
V
I
Q
S
S
Y
L
L
E
K
D
A
A
L
Y
Q
S
Y
F
D
KK
H
Q
K
V
V
A
L
T
FDDGPNPAT
T
P
Q
V
L
E
T
L
A
KYD
I
K
A
T
F
F
V
L
GKNVS-G-
N
-
E
D
L
V
K
R
I
K
SEG
H
V
VGNHSWS
H
P
I
L
S
Q
L
------
S
L
D
E
A
K
K
QIT
D
T
E
D
V
L
T
K
V
LGSS-S-K--L-MRPPY---G
A
I
T
D
D
---
I
---
R
N-------------SL---
D
---
L
S
F
I
M
W
DVDSLDW-KSK--
N
E
-
A
---
S
I
L
T
E
-----
I
Q
H
----
Q
V--A----------------N--
G
S
I
V
L
M
HDIHS---
P
T
V
N
--
A
L
P
-
R
V
I
E
Y
L
KNQG
Y
T
F
V
T
I
P
E
M
L
N
T
R
L
K
A
H
E
L
YYSRDE
1
PsiBlast_PDB
93.57
99%
-80
- C6 -
-
2C1G
1
PGDA_STRR6
A:
[14-431]
---------------------------------------------
F
E
Q
K
I
E
S
L
K
K
E
K
D
D
Q
L
S
E
G
N
Q
K
E
H
F
R
Q
G
Q
A
E
V
I
A
Y
Y
P
L
Q
G
E
K
V
I
S
S
V
R
E
L
I
N
Q
D
V
K
D
K
L
E
-
S
-
K
D
N
L
V
F
Y
Y
T
E
Q
E
E
S
G
L
K
G
V
V
N
R
N
V
T
K
Q
I
Y
D
L
-
V
A
F
----
K
I
E
E
T
E
K
T
S
L
G
K
V
H
L
T
E
D
G
Q
P
F
T
L
D
Q
L
F
S
D
A
S
K
A
K
E
Q
L
I
K
E
L
T
S
F
-------------------------
W
N
F
D
Y
K
D
S
Q
I
I
L
Y
---------
E
I
A
L
P
V
S
A
F
F
D
V
I
Q
S
S
Y
L
L
E
K
D
A
A
L
Y
Q
S
Y
F
D
K
K
H
Q
K
V
V
A
L
T
F
D
D
G
P
N
P
A
T
T
P
Q
V
L
E
T
L
A
K
Y
D
I
K
A
T
F
F
V
L
G
K
N
V
S
-
G
-
N
-
E
D
L
V
K
R
I
K
S
E
G
H
V
V
G
N
H
S
W
S
H
P
I
L
S
Q
L
------
S
L
D
E
A
K
K
Q
I
T
D
T
E
D
V
L
T
K
V
L
G
S
S
-
S
-
K
--
L
-
M
R
P
P
Y
---
G
A
I
T
D
D
---
I
---
R
N
-------------
S
L
---
D
---
L
S
F
I
M
W
D
V
D
S
L
D
W
-
K
S
K
--
N
E
-
A
---
S
I
L
T
E
-----
I
Q
H
----
Q
V
--
A
----------------
N
--
G
S
I
V
L
M
H
D
I
H
S
---
P
T
V
N
--
A
L
P
-
R
V
I
E
Y
L
K
N
Q
G
Y
T
F
V
T
I
P
E
M
L
N
T
R
L
K
A
H
E
L
Y
Y
S
R
D
E
2
PsiBlast_PDB
92.91
98%
-77
- C6 -
-
2C1I
1
PGDA_STRR6
A:
[14-431]
---------------------------------------------
F
E
Q
K
I
E
S
L
K
K
E
K
D
D
Q
L
S
E
G
N
Q
K
E
H
F
R
Q
G
Q
A
E
V
I
A
Y
Y
P
L
Q
G
E
K
V
I
S
S
V
R
E
L
I
N
Q
D
V
K
D
K
L
E
-
S
-
K
D
N
L
V
F
Y
Y
T
E
Q
E
E
S
G
L
K
G
V
V
N
R
N
V
T
K
Q
I
Y
D
----------
I
E
E
T
E
K
T
S
L
G
K
V
H
L
T
E
D
G
Q
P
F
T
L
D
Q
L
F
S
D
A
S
K
A
K
E
Q
L
I
K
E
L
T
S
F
---------------------
D
L
S
A
W
N
F
D
Y
K
D
S
Q
I
I
L
Y
---------
E
I
A
L
P
V
S
A
F
F
D
V
I
Q
S
S
Y
L
L
E
K
D
A
A
L
Y
Q
S
Y
F
D
K
K
H
Q
K
V
V
A
L
T
F
N
D
G
P
N
P
A
T
T
P
Q
V
L
E
T
L
A
K
Y
D
I
K
A
T
F
F
V
L
G
K
N
V
S
-
G
-
N
-
E
D
L
V
K
R
I
K
S
E
G
H
V
V
G
N
H
S
W
S
H
P
I
L
S
Q
L
------
S
L
D
E
A
K
K
Q
I
T
D
T
E
D
V
L
T
K
V
L
G
S
S
-
S
-
K
--
L
-
M
R
P
P
Y
---
G
A
I
T
D
D
---
I
---
R
N
-------------
S
L
---
D
---
L
S
F
I
M
W
D
V
D
S
L
D
W
-
K
S
K
--
N
E
-
A
---
S
I
L
T
E
-----
I
Q
H
----
Q
V
--
A
----------------
N
--
G
S
I
V
L
M
H
D
I
H
S
---
P
T
V
N
--
A
L
P
-
R
V
I
E
Y
L
K
N
Q
G
Y
T
F
V
T
I
P
E
M
L
N
T
R
L
K
A
H
E
L
Y
Y
S
R
D
E
74
Fugue
92.22
98%
-76
- C6 -
-
2C1I
1
PGDA_STRR6
A:
[14-431]
---------------------------------------------
F
E
Q
K
I
E
S
L
K
K
E
K
D
D
Q
L
S
E
G
N
Q
K
E
H
F
R
Q
G
Q
A
E
V
I
A
Y
Y
P
L
Q
G
E
K
V
I
S
S
V
R
E
L
I
N
Q
D
V
K
D
K
L
E
-
S
-
K
D
N
L
V
F
Y
Y
T
E
Q
E
E
S
G
L
K
G
V
V
N
R
N
V
T
K
Q
I
Y
D
I
----------
E
E
T
E
K
T
S
L
G
K
V
H
L
T
E
D
G
Q
P
F
T
L
D
Q
L
F
S
D
A
S
K
A
K
E
Q
L
I
K
E
L
T
S
---------------------
F
D
L
S
A
W
N
F
D
Y
K
D
S
Q
I
I
L
---------
Y
E
I
A
L
P
V
S
A
F
F
D
V
I
Q
S
S
Y
L
L
E
K
D
A
A
L
Y
Q
S
Y
F
D
K
K
H
Q
K
V
V
A
L
T
F
N
D
G
P
N
P
A
T
T
P
Q
V
L
E
T
L
A
K
Y
D
I
K
A
T
F
F
V
L
G
K
N
V
S
-
G
-
N
-
E
D
L
V
K
R
I
K
S
E
G
H
V
V
G
N
H
S
W
S
H
P
I
L
S
Q
L
------
S
L
D
E
A
K
K
Q
I
T
D
T
E
D
V
L
T
K
V
L
G
S
S
-
S
-
K
--
L
-
M
R
P
P
Y
---
G
A
I
T
D
D
---
I
---
R
N
-------------
S
L
---
D
---
L
S
F
I
M
W
D
V
D
S
L
D
W
-
K
S
K
--
N
E
-
A
---
S
I
L
T
E
-----
I
Q
H
----
Q
V
--
A
----------------
N
--
G
S
I
V
L
M
H
D
I
H
S
---
P
T
V
N
--
A
L
P
-
R
V
I
E
Y
L
K
N
Q
G
Y
T
F
V
T
I
P
E
M
L
N
T
R
L
K
A
H
E
L
Y
Y
S
R
D
E
51
HHSearch
76.40
94%
47
- C6 -
-
2C1I
1
PGDA_STRR6
A:
[14-430]
---------------------------------------------
F
E
Q
K
I
E
S
L
K
K
E
K
D
D
Q
L
S
E
G
N
Q
K
E
H
F
R
Q
G
Q
A
E
V
I
A
Y
Y
P
L
Q
G
E
K
V
I
S
S
V
R
E
L
I
N
Q
D
V
K
D
K
L
E
S
K
-
D
N
L
V
F
Y
Y
T
E
-
Q
E
E
S
G
L
K
G
V
V
N
R
N
V
T
K
Q
I
Y
D
-----I
E
E
T
E
K
----
T
S
L
G
K
-
V
H
L
T
E
D
G
Q
P
F
T
L
D
Q
L
F
S
D
A
S
K
A
K
E
Q
L
I
K
E
L
T
S
F
---------------------
D
L
S
A
W
N
F
D
Y
K
D
S
Q
I
I
L
Y
---------
E
I
A
L
P
V
S
A
F
F
D
V
I
Q
S
S
Y
L
L
E
K
D
A
A
L
Y
Q
S
Y
F
D
K
K
H
Q
K
V
V
A
L
T
F
N
D
G
P
N
P
A
T
T
P
Q
V
L
E
T
L
A
K
Y
D
I
K
A
T
F
F
V
L
G
K
N
V
S
-
G
-
N
-
E
D
L
V
K
R
I
K
S
E
G
H
V
V
G
N
H
S
W
S
H
P
I
L
S
Q
L
------
S
L
D
E
A
K
K
Q
I
T
D
T
E
D
V
L
T
K
V
L
G
S
S
-
S
-
K
--
L
-
M
R
P
P
Y
---
G
A
I
T
D
D
---
I
---
R
N
-------------
S
L
---
D
---
L
S
F
I
M
W
D
V
D
S
L
D
W
-
K
S
K
--
N
E
-
A
---
S
I
L
T
E
-----
I
Q
H
----
Q
V
--
A
----------------
N
--
G
S
I
V
L
M
H
D
I
H
S
---
P
T
V
N
--
A
L
P
-
R
V
I
E
Y
L
K
N
Q
G
Y
T
F
V
T
I
P
E
M
L
N
T
R
L
K
A
H
E
L
Y
Y
S
R
D
-
50
HHSearch
74.08
95%
66
- C6 -
-
2C1G
1
PGDA_STRR6
A:
[14-430]
---------------------------------------------
F
E
Q
K
I
E
S
L
K
K
E
K
D
D
Q
L
S
E
G
N
Q
K
E
H
F
R
Q
G
Q
A
E
V
I
A
Y
Y
P
L
Q
G
E
K
V
I
S
S
V
R
E
L
I
N
Q
D
V
K
D
K
L
E
-
S
K
D
N
L
V
F
Y
Y
T
E
-
Q
E
E
S
G
L
K
G
V
V
N
R
N
V
T
K
Q
I
Y
D
L
V
A
F
K
I
E
E
T
E
K
----
T
S
L
G
K
-
V
H
L
T
E
D
G
Q
P
F
T
L
D
Q
L
F
S
D
A
S
K
A
K
E
Q
L
I
K
E
L
T
S
F
-------------------------
W
N
F
D
Y
K
D
S
Q
I
I
L
Y
---------
E
I
A
L
P
V
S
A
F
F
D
V
I
Q
S
S
Y
L
L
E
K
D
A
A
L
Y
Q
S
Y
F
D
K
K
H
Q
K
V
V
A
L
T
F
D
D
G
P
N
P
A
T
T
P
Q
V
L
E
T
L
A
K
Y
D
I
K
A
T
F
F
V
L
G
K
N
V
S
-
G
-
N
-
E
D
L
V
K
R
I
K
S
E
G
H
V
V
G
N
H
S
W
S
H
P
I
L
S
Q
L
------
S
L
D
E
A
K
K
Q
I
T
D
T
E
D
V
L
T
K
V
L
G
S
S
-
S
-
K
--
L
-
M
R
P
P
Y
---
G
A
I
T
D
D
---
I
---
R
N
-------------
S
L
---
D
---
L
S
F
I
M
W
D
V
D
S
L
D
W
-
K
S
K
--
N
E
-
A
---
S
I
L
T
E
-----
I
Q
H
----
Q
V
--
A
----------------
N
--
G
S
I
V
L
M
H
D
I
H
S
---
P
T
V
N
--
A
L
P
-
R
V
I
E
Y
L
K
N
Q
G
Y
T
F
V
T
I
P
E
M
L
N
T
R
L
K
A
H
E
L
Y
Y
S
R
D
-
52
HHSearch
52.08
30%
-49
- C6 -
-
2J13
-
?
A:
[51-245]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
T
K
K
K
D
I
Y
L
T
F
D
N
G
Y
E
N
G
Y
T
G
K
I
L
D
V
L
K
E
K
K
V
P
A
T
F
F
V
T
G
H
Y
I
K
-
T
-
Q
-
K
D
L
L
L
R
M
K
D
E
G
H
I
I
G
N
H
S
W
S
H
P
D
F
T
A
V
------
N
D
E
K
L
R
E
E
L
T
S
V
T
E
E
I
K
K
V
T
G
Q
K
E
V
-
K
--
Y
-
V
R
P
P
R
---
G
V
F
S
E
R
---
T
---
L
A
-------------
L
T
K
E
M
G
---
Y
Y
N
V
F
W
S
L
A
F
L
D
W
-------------------------------
I
--
H
----------------
P
--
G
S
I
L
L
L
H
A
I
S
K
---
D
N
A
E
--
A
L
A
-
K
I
I
D
D
L
R
E
K
G
Y
H
F
K
S
L
D
D
L
V
K
S
N
------------
4
PsiBlast_PDB
51.92
37%
7
- C6 -
-
2C79
-
?
A:
[5-189]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
L
V
A
L
T
F
D
D
G
P
D
N
V
L
T
A
R
V
L
D
K
L
D
K
Y
N
V
K
A
T
F
M
V
V
G
Q
R
V
N
D
S
-
T
-
A
A
I
I
R
R
M
V
N
S
G
H
E
I
G
N
H
S
W
S
Y
S
G
M
A
N
M
------
S
P
D
Q
I
R
K
S
I
A
D
T
N
A
V
I
Q
K
Y
A
G
T
T
-
P
-
K
--
F
-
F
R
P
P
N
---
L
E
T
S
P
T
---
L
---
F
N
-------------
N
V
---
D
---
L
V
F
V
-
G
G
L
T
A
N
D
W
I
P
S
T
--
T
A
-
E
---
Q
R
A
A
A
-----
V
I
N
----
G
V
--
R
----------------
D
--
G
T
I
I
L
L
H
D
V
Q
P
EPH
P
T
P
E
--
A
L
D
-
I
I
I
P
T
L
K
S
R
G
Y
E
F
V
T
L
T
E
L
F
---------------
58
HHSearch
51.89
37%
2
- C6 -
-
2C71
-
?
A:
[5-195]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
L
V
A
L
T
F
D
D
G
P
D
N
V
L
T
A
R
V
L
D
K
L
D
K
Y
N
V
K
A
T
F
M
V
V
G
Q
R
V
N
-
D
S
T
-
A
A
I
I
R
R
M
V
N
S
G
H
E
I
G
N
H
S
W
S
Y
S
G
M
A
N
M
------
S
P
D
Q
I
R
K
S
I
A
D
T
N
A
V
I
Q
K
Y
A
G
T
T
-
P
-
K
--
F
-
F
R
P
P
N
---
L
E
T
S
P
T
---
L
---
F
N
-------------
N
V
---
D
---
L
-
V
F
V
G
G
L
T
A
N
D
W
-
I
P
S
--
T
T
A
E
---
Q
R
A
A
A
-----
V
I
N
----
G
V
--
R
----------------
D
--
G
T
I
I
L
L
H
D
V
Q
P
EPH
P
T
P
E
--
A
L
D
-
I
I
I
P
T
L
K
S
R
G
Y
E
F
V
T
L
T
E
L
F
T
L
K
G
V
P
---------
59
HHSearch
51.72
36%
-46
- C6 -
-
2Y8U
-
?
B:
[29-224]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
C
T
T
P
N
T
I
A
L
T
F
D
D
G
P
S
E
Y
-
T
P
Q
L
L
D
L
L
S
R
Y
S
A
R
A
T
F
F
V
L
G
D
A
A
A
-
Q
-
N
-
P
G
L
L
Q
R
M
R
D
E
G
H
Q
V
G
A
H
T
Y
D
H
V
S
L
P
S
L
------
G
Y
D
G
I
A
S
Q
M
T
R
L
E
E
V
I
R
P
A
L
G
V
A
-
P
-
A
--
Y
-
M
R
P
P
Y
---
L
E
T
N
E
L
---
V
---
L
Q
-------------
V
M
R
D
L
D
---
Y
R
V
I
S
A
S
V
D
T
K
D
Y
-
E
N
Q
--
D
A
-
D
---
A
I
I
N
T
-----
S
F
Q
L
F
L
D
Q
L
D
-
A
----------------
G
--
G
N
I
V
L
A
H
D
I
H
Y
---
W
T
V
A
S-
L
A
E
-
R
M
L
Q
E
V
N
A
R
G
L
I
A
T
T
V
G
D
C
L
G
D
G
------------
3
PsiBlast_PDB
51.62
37%
7
- C6 -
-
2C71
-
?
A:
[5-189]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
L
V
A
L
T
F
D
D
G
P
D
N
V
L
T
A
R
V
L
D
K
L
D
K
Y
N
V
K
A
T
F
M
V
V
G
Q
R
V
N
D
S
-
T
-
A
A
I
I
R
R
M
V
N
S
G
H
E
I
G
N
H
S
W
S
Y
S
G
M
A
N
M
------
S
P
D
Q
I
R
K
S
I
A
D
T
N
A
V
I
Q
K
Y
A
G
T
T
-
P
-
K
--
F
-
F
R
P
P
N
---
L
E
T
S
P
T
---
L
---
F
N
-------------
N
V
---
D
---
L
V
F
V
-
G
G
L
T
A
N
D
W
I
P
S
T
--
T
A
-
E
---
Q
R
A
A
A
-----
V
I
N
----
G
V
--
R
----------------
D
--
G
T
I
I
L
L
H
D
V
Q
P
EPH
P
T
P
E
--
A
L
D
-
I
I
I
P
T
L
K
S
R
G
Y
E
F
V
T
L
T
E
L
F
---------------
61
HHSearch
51.58
32%
-13
- C6 -
-
1NY1
-
PDAA_BACSU
B:
[61-257]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
N
T
K
E
K
T
I
Y
L
T
F
D
N
G
Y
E
N
G
Y
T
P
K
V
L
D
V
L
K
K
H
R
V
T
G
T
F
F
V
T
G
H
F
V
K
-
D
-
Q
-
P
Q
L
I
K
R
M
S
D
E
G
H
I
I
G
N
H
S
F
H
H
P
D
L
T
T
K
------
T
A
D
Q
I
Q
D
E
L
D
S
V
N
E
E
V
Y
K
I
T
G
K
Q
-
D
N
L
--
Y
-
L
R
P
P
R
---
G
V
F
S
E
Y
---
V
---
L
K
-------------
E
T
---
K
RLG
Y
Q
T
V
F
W
S
V
A
F
V
D
W
-
K
I
N
--
N
Q
-
K
GKK
Y
A
Y
D
H
-----
M
I
K
----
Q
A
--
H
----------------
P
--
G
A
I
Y
L
L
H
T
V
S
R
---
D
N
A
E
--
A
L
D
-
D
A
I
T
D
L
K
K
Q
G
Y
T
F
K
S
I
D
D
L
M
F
E
K
E
-----------
10
PsiBlast_PDB
51.51
31%
-47
- C6 -
-
5JP6
-
?
A:
[168-362]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
K
E
V
V
L
T
F
D
D
G
P
H
G
L
Y
T
D
A
I
L
R
A
L
K
E
V
N
A
K
A
M
F
F
A
T
G
K
S
V
R
-
T
-
N
-
P
E
A
L
K
R
V
A
A
D
G
H
V
I
G
S
H
S
I
T
------
L
------
T
F
D
E
A
A
A
E
V
R
G
G
H
Q
A
V
F
D
V
L
G
W
V
-
D
-
P
--
V
-
F
R
F
-
Y
---
G
E
T
S
K
D
---
L
---
K
A
-------------
F
L
K
T
K
S
---
T
G
E
F
A
W
N
I
E
S
D
D
W
-
R
T
Q
--
S
N
-
E
---
Q
L
L
A
R
-----
V
L
A
----
N
V
--
E
----------------
S
Q
G
R
G
I
V
L
F
H
D
I
Q
R
---
R
T
A
E
--
I
M
P
-
Q
F
L
R
E
L
Y
N
R
G
Y
S
V
V
L
L
-------------------
9
PsiBlast_PDB
51.25
30%
-46
- C6 -
-
2J13
-
?
A:
[40-244]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
Q
K
N
G
G
F
Y
L
G
--
D
T
K
-
K
K
D
I
Y
L
T
F
D
N
G
Y
E
N
G
Y
T
G
K
I
L
D
V
L
K
E
K
K
V
P
A
T
F
F
V
T
G
H
Y
I
K
-
T
-
Q
-
K
D
L
L
L
R
M
K
D
E
G
H
I
I
G
N
H
S
W
S
H
P
D
F
T
A
V
------
N
D
E
K
L
R
E
E
L
T
S
V
T
E
E
I
K
K
V
T
G
Q
K
-
E
V
K
--
Y
-
V
R
P
P
R
---
G
V
F
S
E
R
T
L
A
L
---
T
K
-------------
E
M
---
G
---
Y
Y
N
V
F
W
S
L
A
F
L
D
W
-------------------------------
I
--
H
----------------
P
--
G
S
I
L
L
L
H
A
I
S
K
---
D
N
A
E
--
A
L
A
-
K
I
I
D
D
L
R
E
K
G
Y
H
F
K
S
L
D
D
L
V
K
S
-------------
6
PsiBlast_PDB
51.12
35%
-52
- C6 -
-
2Y8U
-
?
A:
[33-222]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
T
I
A
L
T
F
D
D
G
P
S
-
E
Y
T
P
Q
L
L
D
L
L
S
R
Y
S
A
R
A
T
F
F
V
L
G
D
A
A
A
-
Q
-
N
-
P
G
L
L
Q
R
M
R
D
E
G
H
Q
V
G
A
H
T
Y
D
H
V
S
L
P
S
L
------
G
Y
D
G
I
A
S
Q
M
T
R
L
E
E
V
I
R
P
A
L
G
V
A
-
P
-
A
--
Y
-
M
R
P
P
Y
LET
N
E
L
V
L
Q
---
V
---
M
R
-------------
D
L
---
D
---
Y
R
V
I
S
A
S
V
D
T
K
D
Y
-
E
N
Q
--
D
A
-
D
---
A
I
I
N
T
S
F
Q
L
F
L
D
Q
----
L
D
--
A
----------------
G
--
G
N
I
V
L
A
H
D
I
H
Y
---
W
T
V
A
--
S
L
A
E
R
M
L
Q
E
V
N
A
R
G
L
I
A
T
T
V
G
D
C
L
G
--------------
5
PsiBlast_PDB
50.21
32%
-28
- C6 -
-
1W17
-
PDAA_BACSU
A:
[47-253]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
N
S
L
I
E
K
Y
D
A
F
Y
---
L
G
N
T
K
E
K
T
I
Y
L
T
F
D
N
G
Y
E
N
G
Y
T
P
K
V
L
D
V
L
K
K
H
R
V
T
G
T
F
F
V
T
G
H
F
V
K
-
D
-
Q
-
P
Q
L
I
K
R
M
S
D
E
G
H
I
I
G
N
H
S
F
H
H
P
D
L
T
T
K
------
T
A
D
Q
I
Q
D
E
L
D
S
V
N
E
E
V
Y
K
I
T
G
K
Q
-
D
-
N
--
L
Y
L
R
P
P
R
---
G
V
F
S
E
Y
---
V
L
K
E
T
K
-------------
R
L
---
G
---
Y
Q
T
V
F
W
S
V
A
F
V
D
W
-
K
I
N
--
N
Q
-
K
---
G
K
K
Y
A
-----
Y
D
H
M
I
K
-
Q
A
--
H
----------------
P
--
G
A
I
Y
L
L
H
T
V
S
R
---
D
N
A
E
--
A
L
D
-
D
A
I
T
D
L
K
K
Q
G
Y
T
F
K
S
I
D
D
L
M
---------------
56
HHSearch
48.98
32%
-30
- C6 -
-
2CC0
-
?
A:
[3-190]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
C
N
G
Y
V
G
L
T
F
D
D
G
P
S
G
S
-
T
Q
S
L
L
N
A
L
R
Q
N
G
L
R
A
T
M
F
N
Q
G
Q
Y
A
A
-
Q
-
N
-
P
S
L
V
R
A
Q
V
D
A
G
M
W
V
A
N
H
S
Y
T
H
P
H
M
T
Q
L
------
G
Q
A
Q
M
D
S
E
I
S
R
T
Q
Q
A
I
A
G
A
G
G
G
T
-
P
-
K
--
L
-
F
R
P
P
Y
---
G
E
T
N
A
T
---
L
---
R
S
-------------
V
E
---
A
K
Y
G
L
T
E
V
I
W
D
V
D
S
Q
D
W
-
N
N
A
--
S
T
-
D
---
A
I
V
Q
A
-----
V
S
-----
R
L
--
G
----------------
N
--
G
Q
V
I
L
M
H
D
W
P
A
---
N
T
L
A
--
A
I
P
-
R
I
A
Q
T
L
A
G
K
G
L
C
S
G
M
I
S
P
Q
T
G
R
A
V
-----------
8
PsiBlast_PDB
48.73
33%
-21
- C6 -
-
1NY1
-
PDAA_BACSU
A:
[47-252]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
N
S
L
I
E
K
Y
D
A
F
Y
---
L
G
N
T
K
E
K
T
I
Y
L
T
F
D
N
G
Y
E
N
G
Y
T
P
K
V
L
D
V
L
K
K
H
R
V
T
G
T
F
F
V
T
G
H
F
V
K
-
D
-
Q
-
P
Q
L
I
K
R
M
S
D
E
G
H
I
I
G
N
H
S
F
H
H
P
D
L
T
T
K
------
T
A
D
Q
I
Q
D
E
L
D
S
V
N
E
E
V
Y
K
I
T
G
K
Q
-
D
-
N
--
L
Y
L
R
P
P
R
---
G
V
F
S
E
Y
---
V
L
K
E
T
K
-------------
R
L
---
G
---
Y
Q
T
V
F
W
S
V
A
F
V
D
W
-
K
I
N
--
N
Q
-
K
---
G
K
K
Y
A
-----
Y
D
H
M
I
K
-
Q
A
--
H
----------------
P
--
G
A
I
Y
L
L
H
T
V
S
R
---
D
N
A
E
--
A
L
D
-
D
A
I
T
D
L
K
K
Q
G
Y
T
F
K
S
I
D
D
L
----------------
55
HHSearch
47.74
32%
-37
- C6 -
-
5JP6
-
?
A:
[165-371]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
V
A
R
K
E
V
V
L
T
F
D
D
G
P
H
G
L
Y
T
D
A
I
L
R
A
L
K
E
V
N
A
K
A
M
F
F
A
T
G
K
S
V
R
-
T
-
N
-
P
E
A
L
K
R
V
A
A
D
G
H
V
I
G
S
H
S
I
T
------
L
------
T
F
D
E
A
A
A
E
V
R
G
G
H
Q
A
V
F
D
V
L
G
W
V
-
D
-
P
--
V
-
F
R
F
-
Y
---
G
E
T
S
K
D
---
L
---
K
A
-------------
F
L
K
T
K
S
---
T
G
E
F
A
W
N
I
E
S
D
D
W
-
R
T
Q
--
S
N
-
E
---
Q
L
L
A
R
-----
V
L
A
----
N
V
E
S
Q
----------------
G
--
R
G
I
V
L
F
H
D
I
Q
R
---
R
T
A
E
--
I
M
P
-
Q
F
L
R
E
L
Y
N
R
G
Y
S
V
V
L
L
T
A
A
D
P
S
A
K
Y
----------
63
HHSearch
46.72
28%
-16
- C6 -
-
5JMU
-
?
A:
[16-220]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
P
G
N
K
I
I
Y
L
T
F
D
D
G
P
G
K
Y
-
T
Q
G
L
L
D
V
L
D
K
Y
N
V
K
A
T
F
F
V
T
N
T
H
P
D
---
Y
-
Q
N
M
I
A
E
E
A
K
R
G
H
T
V
A
I
H
S
A
S
H
K
Y
N
Q
I
Y
T-----
S
E
Q
A
F
F
D
D
L
E
Q
M
N
S
I
I
K
A
Q
T
G
N
D
-
A
-
S
--
I
-
I
R
F
P
G
---
G
S
S
N
T
V
---
S
---
K
D
YPG
I
M
T
Q
L
V
N
D
V
T
A
R
---
G
---
L
L
Y
C
D
W
N
V
S
S
G
D
A
-
N
P
K
P
I
S
T
-
E
---
Q
V
V
Q
N
-----
V
I
S
----
G
V
Q
S
H
----------------
N
--
V
S
V
V
L
Q
H
D
I
K
E
---
F
S
V
N
--
A
V
E
-
Q
I
I
Q
W
G
Q
A
N
G
Y
T
F
L
P
L
T
T
S
S
P
M
S
------------
13
PsiBlast_PDB
45.26
31%
-24
- C6 -
-
2W3Z
-
?
A:
[106-310]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
K
L
V
F
L
T
F
D
D
G
V
D
P
N
M
T
P
K
I
L
D
V
L
A
Q
Q
H
V
H
A
T
F
F
L
V
G
C
N
I
T
-
D
-
K
V
K
P
I
L
Q
R
Q
I
T
E
G
H
A
L
G
I
H
S
F
S
H
-
V
Y
S
L
L
Y
PNRVG
N
T
Q
Q
I
V
S
E
V
T
R
T
Q
N
A
L
K
D
Q
L
G
Q
N
-
F
-
K
TG
V
-
W
R
Y
P
G
---
G
H
L
S
W
T
---
G
---
L
E
-------------
A
A
---
D
---
K
Q
L
A
A
Q
G
I
Q
W
M
D
W
-
N
A
A
V-
G
D
-
A
---
E
P
L
A
T
-----
R
P
T
----
T
V
--
A
S
M
L
A
F
L
D
G
S
A
K
IATNP
N
--
V
Q
V
V
L
M
H
D
I
S
E
---
K
T
I
T
L
A
S
L
P
-
Q
I
I
R
Y
Y
K
D
R
G
Y
T
F
A
V
L
-------------------