@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : spr1336: (2018-01-10 )
MKTKLPTEWQELSDQLGFQEFTPIQTQLFEPLLAGENLLGVSQTGTGKTLAYLLPSLLRLQKKKAQQLLILAPNTELAGQIFDVCKTWAEAIGLTAQLFLSGSSQKRQIERLKKGPEILIGTPGRIFELIKLKKIKMMNVETIILDEFDQLLDDSQIHFVEKITHYAPRDHQLVYMSATTKFDQEKIVPNTRTIDLSDQKLDNIQHFYMQVDQRHRVDMLRKLAHVEDFRGLVFFNSLSDLGNAEEKLQYRDILAVSLASDVNVKFRKIILEKFKDNQLTLLLATDLLARGIDIDSLECVVNFDIPRDSETYTHRAGRTGRMGKEGYVITLVTHPEEIKKLKKFASIREIVLKNQELYIK
Atome Classification :
(30 SA)
.........10..-......20----.........30..---.--.--.-...40........50....---....------60---.-.--.----------...-..--.70........80........90-.------.......100....-..-.110....------.-..120......-.130--..---......140.......150.....-..160-....--.----.------..170.--......-----180.----.....------.----190--.----.-.---...--.--..--200-.......210.-.-.-.....220.-------------.-.....230........240..-.....250........260.......270.......280.......290.......300....------...310.......320.......330.......340.......350.......360
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MKTKLP
T
E
W
Q
E
L
S
-
D
QLGFQE-----FT
P
I
Q
T
Q
L
F
E
P
L
L---A--G--E-
N
L
LGVSQTGTG
K
T
L
A
Y
L
L
P
---
S
L
L
R
------
L
----
Q
-
K
--K----------KA
Q
-
Q
L
--
L
I
LAPN
T
E
L
A
G
Q
I
F
D
V
C
K
T
W
A
E
A
-I------GL
T
A
Q
L
F
LSGS
S
Q
K
-
R
Q
-
I
E
R
L
KKGP------
E
-
I
L
IGT
P
G
R
I
F
E
-
L
I
-
K
--
L
K
---
K
I
K
M
MN
V
E
T
I
I
L
D
E
F
D
Q
L
LDDS
Q
I
-
H
F
V
E
--
K
I
T
H--Y----A------PRD
H
Q
L
--
V
Y
M
SAT-----TKFD----QEKIV------P----N----T----
R
-
T
---IDL--
S
--
D
Q
--
K
L
D
-
N
I
Q
H
F
Y
M
Q
V
-
D
-
Q
-
R
-
H
R
V
D
M
L
R
K
L
-------------
A
-
H
V
E
D
F
R
-
G
L
V
F
F
N
S
L
S
DLG
N
A
-
E
E
K
L
Q
Y
R
-
D
I
L
A
V
SLASDV
N
V
K
F
R
K
I
I
L
E
KFKDN
Q
L
T
L
L
L
A
T
D
L
L
ARGIDID
S
L
E
C
V
V
N
FDIP------RDSETYTHRAGRTGRMGKE
G
Y
V
I
T
L
VT
H
P
E
E
I
K
K
L
K
K
F
A
S
I
R
E
I
V
LKNQ
E
L
Y
IK
91
HHSearch
74.72
33%
-3
- C2 -
-
5IVL
-
?
B:
[6-351]
-
E
L
G
L
S
Q
E
V
M
K
A
I
-
E
R
M
G
F
E
E
-----
T
T
P
I
Q
A
K
T
I
P
L
S
L
---
Q
--
N
--
K
-
D
V
I
G
Q
A
Q
T
G
T
G
K
T
A
A
F
G
I
P
---
I
V
E
K
------
V
----
D
-
V
K-
N
----------
G
A
I
-
Q
A
--
L
V
V
A
P
T
R
E
L
A
I
Q
V
S
E
E
L
Y
K
I
G
A
V
-
K
------
R
V
R
V
L
P
I
Y
G
G
Q
D
I
E
-
R
Q
-
I
R
A
L
K
K
H
P
------
H
-
V
I
V
G
T
P
G
R
I
I
D
-
H
I
-
N
--
R
G
---
T
L
R
L
E
H
V
H
T
V
V
L
D
E
A
D
E
M
L
--
G
F
I
-
E
D
I
E
--
A
I
L
S
--
H
----
V
------
P
A
E
R
Q
T
--
L
L
F
S
A
T
-----
M
P
D
P
----
I
R
R
I
A
------
E
R
FMN
E
----
P
----
E
-
L
---
V
K
V
--
K
A------
V
P
-
N
I
Q
Q
Y
Y
L
E
V
-
H
-
E
-
K
-
K
K
F
D
I
L
T
R
L
-------------
L
D
I
Q
A
P
E
L
-
A
I
V
F
G
R
T
K
R
R
V
D
E
L
-
A
E
A
L
N
L
R
-
G
Y
A
A
E
G
I
H
G
D
L
S
Q
A
K
R
L
S
V
L
R
K
F
K
E
G
A
I
E
I
L
V
A
T
D
V
A
A
R
G
L
D
I
S
G
V
T
H
V
Y
N
F
D
I
P
------
Q
D
P
E
S
Y
V
H
R
I
G
R
T
G
R
A
G
K
T
G
V
A
M
T
F
V
T
P
R
E
------------------------
1
PsiBlast_PDB
74.33
33%
-1
- C2 -
-
5IVL
-
?
B:
[9-355]
----
L
S
Q
E
V
M
K
A
I
-
E
R
M
G
F
E
E
-----
T
T
P
I
Q
A
K
T
I
P
L
S
L
---
Q
--
N
--
K
-
D
V
I
G
Q
A
Q
T
G
T
G
K
T
A
A
F
G
I
P
---
I
V
E
K
------
V
----
D
V
K
--
N
----------
G
A
I
-
Q
A
--
L
V
V
A
P
T
R
E
L
A
I
Q
V
S
E
E
L
Y
K
I
G
A
V
-
K
------
R
V
R
V
L
P
I
Y
G
G
Q
D
I
E
-
R
Q
-
I
R
A
L
K
K
H
P
------
H
-
V
I
V
G
T
P
G
R
I
I
D
-
H
I
-
N
--
R
G
---
T
L
R
L
E
H
V
H
T
V
V
L
D
E
A
D
E
M
L
--
G
F
I
-
E
D
I
E
--
A
I
L
S
--
H
----
V
------
P
A
E
R
Q
T
--
L
L
F
S
A
T
-----
M
P
D
P
----
I
R
R
I
A
E
R
FMNE
P
----
E
----
L
----
V
-
K
---
V
K
A
----------
V
P
-
N
I
Q
Q
Y
Y
L
E
V
-
H
-
E
-
K
-
K
K
F
D
I
L
T
R
L
-------------
L
-
D
I
Q
A
P
E
L
A
I
V
F
G
R
T
K
R
R
V
D
E
L
-
A
E
A
L
N
L
R
-
G
Y
A
A
E
G
I
H
G
D
L
S
Q
A
K
R
L
S
V
L
R
K
F
K
E
G
A
I
E
I
L
V
A
T
D
V
A
A
R
G
L
D
I
S
G
V
T
H
V
Y
N
F
D
I
P
------
Q
D
P
E
S
Y
V
H
R
I
G
R
T
G
R
A
G
K
T
G
V
A
M
T
F
V
T
-
P
R
E
I
G
Q
L
-------------------
99
HHSearch
73.75
28%
-9
* C3 *
-
1S2M
-
DHH1_YEAST
A:
[51-406]
--
F
Y
L
K
R
E
L
L
M
G
I
-
F
E
A
G
F
E
K
-----
P
S
P
I
Q
E
E
A
I
P
V
A
I
---
T
--
G
--
R
-
D
I
L
A
R
A
K
N
G
T
G
K
T
A
A
F
V
I
P
---
T
L
E
K
------
V
----
K
-
P
--
K
L---------
N
K
I
-
Q
A
--
L
I
M
V
P
T
R
E
L
A
L
Q
T
S
Q
V
V
R
T
L
G
K
H
-
C
------
G
I
S
C
M
V
T
T
G
G
T
N
L
R
-
D
D
-
I
L
R
L
N
E
T
V
------
H
-
I
L
V
G
T
P
G
R
V
L
D
-
L
A
-
S
--
R
K
---
V
A
D
L
S
D
C
S
L
F
I
M
D
E
A
D
K
M
L
S
R
D
F
K
-
T
I
I
E
--
Q
I
L
S
--
F
----
L
------
P
P
T
H
Q
S
--
L
L
F
S
A
T
-----
F
P
L
T
----
V
K
E
F
M
------
V
----
K
----
H
LHKP
Y
-
E
---
I
N
L
--
M
E-
E
L
--
T
L
K
-
G
I
T
Q
Y
Y
A
F
V
-
E
-
E
-
R
-
Q
K
L
H
C
L
N
T
L
-------------
F
S
K
L
Q
I
N
Q
-
A
I
I
F
C
N
S
T
N
R
V
E
L
L
-
A
K
K
I
T
D
L
-
G
Y
S
C
Y
Y
S
H
A
R
M
K
Q
Q
E
R
N
K
V
F
H
E
F
R
Q
G
K
V
R
T
L
V
C
S
D
L
L
T
R
G
I
D
I
Q
A
V
N
V
V
I
N
F
D
F
P
------
K
T
A
E
T
Y
L
H
R
I
G
R
S
G
R
F
G
H
L
G
L
A
I
N
L
I
N
W
N
D
-
R
F
N
L
Y
K
I
E
Q
E
L
G
T
E
I
--------
95
HHSearch
72.94
26%
4
- C2 -
-
4D26
2
?
A:
[56-409]
---
N
L
R
K
Y
V
L
D
N
V
-
L
K
A
G
Y
R
K
-----
P
T
P
I
Q
K
N
A
I
P
I
I
M
---
S
--
G
--
R
-
D
L
M
G
C
A
Q
T
G
S
G
K
T
A
A
F
L
V
P
---
I
I
N
M
------
L
----
L
-
Q
--
D
P
K
D
L
I
S
E
NG
C
A
Q
P
-
Q
V
--
I
I
V
S
P
T
R
E
L
T
L
Q
I
F
N
E
A
R
K
F
S
Y
G
-
S
------
V
L
K
V
A
V
A
Y
G
G
T
A
V
R
-
H
Q
-
G
D
N
I
A
R
G
C
------
H
-
I
L
V
A
T
P
G
R
L
H
D
-
F
V
-
E
--
R
N
---
R
V
S
F
G
S
V
R
F
V
V
L
D
Q
A
D
C
M
L
D
M
G
F
M
-
P
S
I
E
--
K
M
M
L
--
H
PTMV
E
------
T
T
K
R
Q
T
--
L
M
F
S
A
T
-----
F
P
E
D
----
I
Q
H
L
A
------
G
----
R
F
LNN
Y
----
L
-
F
---
V
A
V
G
I
V
--
G
G
--
A
S
T
-
D
V
E
Q
I
F
I
E
V
-
T
-
K
-
Y
-
E
K
R
N
S
L
K
Q
L
-------------
I
E
E
N
D
G
K
R
-
I
L
V
F
V
E
T
K
R
N
A
D
F
I
-
A
A
M
L
S
E
Q
-
Q
L
L
T
S
S
I
H
G
D
R
M
Q
R
E
R
E
E
A
L
Q
N
F
K
S
G
K
H
C
I
L
V
A
T
A
V
A
A
R
G
L
D
I
K
N
V
D
I
V
V
N
Y
D
L
P
------
K
S
I
D
E
Y
V
H
R
I
G
R
T
G
R
V
G
N
R
G
K
A
V
S
F
Y
D
S
D
Q
------------------------
97
HHSearch
72.65
30%
-0
- C2 -
-
4CT4
-
DDX6_HUMAN
B:
[9-367]
-
D
Y
C
L
K
R
E
L
L
M
G
I
-
F
E
M
G
W
E
K
-----
P
S
P
I
Q
E
E
S
I
P
I
A
L
---
S
--
G
--
R
-
D
I
L
A
R
A
K
N
G
T
G
K
S
G
A
Y
L
I
P
---
L
L
E
R
------
L
----
D
-
L
--
K
K---------
D
N
I
-
Q
A
--
M
V
I
V
P
T
R
E
L
A
L
Q
V
S
Q
I
C
I
Q
V
S
K
H
-
M
G-----
G
A
K
V
M
A
T
T
G
G
T
N
L
R
-
D
D
-
I
M
R
L
D
D
T
V
------
H
-
V
V
I
A
T
P
G
R
I
L
D
-
L
I
-
K
--
K
G
---
V
A
K
V
D
H
V
Q
M
I
V
L
D
E
A
D
K
L
L
S
Q
D
F
V
-
Q
I
M
E
--
D
I
I
L
--
T
----
L
------
P
K
N
R
Q
I
--
L
L
Y
S
A
T
-----
F
P
L
S
----
V
Q
K
F
M
------
N
----
S
----
H
LQKP
Y
-
E
---
I
N
L
--
M
E-
E
L
--
T
L
K
-
G
V
T
Q
Y
Y
A
Y
V
-
T
-
E
-
R
-
Q
K
V
H
C
L
N
T
L
-------------
F
S
R
L
Q
I
N
Q
-
S
I
I
F
C
N
S
S
Q
R
V
E
L
L
-
A
K
K
I
S
Q
L
-
G
Y
S
C
F
Y
I
H
A
K
M
R
Q
E
H
R
N
R
V
F
H
D
F
R
N
G
L
C
R
N
L
V
C
T
D
L
F
T
R
G
I
D
I
Q
A
V
N
V
V
I
N
F
D
F
P
------
K
L
A
E
T
Y
L
H
R
I
G
R
S
G
R
F
G
H
L
G
L
A
I
N
L
I
T
Y
D
D
-
R
F
N
L
K
S
I
E
E
Q
L
G
T
E
I
K
-------
96
HHSearch
72.35
26%
5
- C2 -
-
4D25
3
?
A:
[56-409]
---
N
L
R
K
Y
V
L
D
N
V
-
L
K
A
G
Y
R
K
-----
P
T
P
I
Q
K
N
A
I
P
I
I
M
---
S
--
G
--
R
-
D
L
M
G
C
A
Q
T
G
S
G
K
T
A
A
F
L
V
P
---
I
I
N
M
------
L
----
L
-
Q
--
D
PKD
L
I
S
E
NG
C
A
Q
P
-
Q
V
--
I
I
V
S
P
T
R
E
L
T
L
Q
I
F
N
E
A
R
K
F
S
Y
G
-
S
------
V
L
K
V
A
V
A
Y
G
G
T
A
V
R
-
H
Q
-
G
D
N
I
A
R
G
C
------
H
-
I
L
V
A
T
P
G
R
L
H
D
-
F
V
-
E
--
R
N
---
R
V
S
F
G
S
V
R
F
V
V
L
D
Q
A
D
C
M
L
D
M
G
F
M
-
P
S
I
E
--
K
M
M
L
--
H
PTMV
E
------
T
T
K
R
Q
T
--
L
M
F
S
A
T
-----
F
P
E
D
----
I
Q
H
L
A
------
G
----
R
FLNN
Y
----
L
-
F
---
V
A
V
GI
V
--
G
G
--
A
S
T
-
D
V
E
Q
I
F
I
E
V
-
T
-
K
-
Y
-
E
K
R
N
S
L
K
Q
L
-------------
I
E
E
N
D
G
K
R
-
I
L
V
F
V
E
T
K
R
N
A
D
F
I
-
A
A
M
L
S
E
Q
-
Q
L
L
T
S
S
I
H
G
D
R
M
Q
R
E
R
E
E
A
L
Q
N
F
K
S
G
K
H
C
I
L
V
A
T
A
V
A
A
R
G
L
D
I
K
N
V
D
I
V
V
N
Y
D
L
P
------
K
S
I
D
E
Y
V
H
R
I
G
R
T
G
R
V
G
N
R
G
K
A
V
S
F
Y
D
S
D
Q
------------------------
108
HHSearch
71.48
29%
-14
- C2 -
-
1HV8
-
H669_METJA
A:
[10-346]
-
E
L
N
L
S
D
N
I
L
N
A
I
-
R
N
K
G
F
E
K
-----
P
T
D
I
Q
M
K
V
I
P
L
F
L
---
N
--
D
E-
Y
-
N
I
V
A
Q
A
R
T
G
S
G
K
T
A
S
F
A
I
P
---
L
I
E
L
------
V
----
N
-
E
--
N
----------
N
G
I
-
E
A
--
I
I
L
T
P
T
R
E
L
A
I
Q
V
A
D
E
I
E
S
L
K
G
N
-
K
------
N
L
K
I
A
K
I
Y
G
G
K
A
I
Y
-
P
Q
-
I
-
K
A
L
K
N
A
------
N
-
I
V
V
G
T
P
G
R
I
L
D
-
H
I
-
N
--
R
G
---
T
L
N
L
K
N
V
K
Y
F
I
L
D
E
A
D
E
M
L
N
M
G
F
I
-
K
D
V
E
--
K
I
L
N
--
A
----
C
------
N
K
D
K
R
I
--
L
L
F
S
A
T
-----
M
P
R
E
----
I
L
N
L
A
------
K
----
K
----
Y
----
M
G
D
---
Y
S
F
--
I
K
-
A
K
--
I
N
A
-
N
I
E
Q
S
Y
V
E
V
-
N
-
E
-
N
-
E
R
F
E
A
L
C
R
L
-------------
L
-
K
N
K
E
F
Y
-
G
L
V
F
C
K
T
K
R
D
T
K
E
L
-
A
S
M
L
R
D
I
-
G
F
K
A
G
A
I
H
G
D
L
S
Q
S
Q
R
E
K
V
I
R
L
F
K
Q
K
K
I
R
I
L
I
A
T
D
V
M
S
R
G
I
D
V
N
D
L
N
C
V
I
N
Y
H
L
P
------
Q
N
P
E
S
Y
M
H
R
I
G
R
T
G
R
A
G
K
K
G
K
A
I
S
I
I
N
R
R
E
------------------------
93
HHSearch
70.84
26%
14
- C2 -
-
2DB3
2
VASA1_DROME
A:
[62-408]
---
D
L
R
D
I
I
I
D
N
V
-
N
K
S
G
Y
K
I
-----
P
T
P
I
Q
K
C
S
I
P
V
I
S
---
S
--
G
--
R
-
D
L
M
A
C
A
Q
T
G
S
G
K
T
A
A
F
L
L
P
---
I
L
S
K
------
L
----
L
-
E
--
D
P
H
E
L
E
L
----
G
R
P
-
Q
V
--
V
I
V
S
P
T
R
E
L
A
I
Q
I
F
N
E
A
R
K
F
A
F
E
-
S
------
Y
L
K
I
G
I
V
Y
G
G
T
S
F
R
-
H
Q
-
N
E
C
I
T
R
G
C
------
H
-
V
V
I
A
T
P
G
R
L
L
D
-
F
V
-
D
--
R
T
---
F
I
T
F
E
D
T
R
F
V
V
L
D
E
A
D
R
M
L
D
M
G
F
S
-
E
D
M
R
--
R
I
M
T
--
H
----
V
TM----
R
P
E
H
Q
T
--
L
M
F
S
A
T
-----
F
P
E
E
----
I
Q
R
M
A
------
G
E
F
LK
N
----
Y
----
V
-
F
---
V
A
I
--
G
IV
G
G
--
A
C
S
-
D
V
K
Q
T
I
Y
E
V
-
N
-
K
-
Y
-
A
K
R
S
K
L
I
E
I
-------------
L
-
S
E
Q
A
D
G
-
T
I
V
F
V
E
T
K
R
G
A
D
F
L
-
A
S
F
L
S
E
K
-
E
F
P
T
T
S
I
H
G
D
R
L
Q
S
Q
R
E
Q
A
L
R
D
F
K
N
G
S
M
K
V
L
I
A
T
S
V
A
S
R
G
L
D
I
K
N
I
K
H
V
I
N
Y
D
M
P
------
S
K
I
D
D
Y
V
H
R
I
G
R
T
G
R
V
G
N
N
G
R
A
T
S
F
F
D
P
E
K
------------------------
2
PsiBlast_PDB
70.79
31%
0
- C2 -
-
1HV8
-
H669_METJA
A:
[25-351]
-----------------
G
F
E
K
-----
P
T
D
I
Q
M
K
V
I
P
L
F
L
---
N
--
D
--
E
Y
N
I
V
A
Q
A
R
T
G
S
G
K
T
A
S
F
A
I
P
---
L
I
E
L
------
V
----
N
-
E
--
N
----------
N
G
I
-
E
A
--
I
I
L
T
P
T
R
E
L
A
I
Q
V
A
D
E
I
E
S
L
K
G
N
-
K
------
N
L
K
I
A
K
I
Y
G
G
K
A
I
Y
-
P
Q
-
I
K
A
L
K
N
A
-------
N
-
I
V
V
G
T
P
G
R
I
L
D
-
H
I
-
N
--
R
G
---
T
L
N
L
K
N
V
K
Y
F
I
L
D
E
A
D
E
M
L
N
M
G
F
I
-
K
D
V
E
--
K
I
L
N
--
A
----
C
------
N
K
D
K
R
I
--
L
L
F
S
A
T
-----
M
P
R
E
----
I
L
N
L
A
------
K
----
K
----
Y
----
M
-
G
----
D
Y
--
S
F
I
K
A
--
K
I
N
A
N
I
E
Q
S
Y
V
E
V
-
N
-
E
-
N
-
E
R
F
E
A
L
C
R
L
-------------
L
-
K
N
K
E
F
Y
-
G
L
V
F
C
K
T
K
R
D
T
K
E
L
-
A
S
M
L
R
D
I
-
G
F
K
A
G
A
I
H
G
D
L
S
Q
S
Q
R
E
K
V
I
R
L
F
K
Q
K
K
I
R
I
L
I
A
T
D
V
M
S
R
G
I
D
V
N
D
L
N
C
V
I
N
Y
H
L
P
------
Q
N
P
E
S
Y
M
H
R
I
G
R
T
G
R
A
G
K
K
G
K
A
I
S
I
I
N
R
-
R
E
Y
K
K
L
R
------------------
7
PsiBlast_PDB
69.66
29%
-10
- C2 -
-
4BRW
2
DHH1_YEAST
A:
[18-342]
---------------
E
A
G
F
E
K
-----
P
S
P
I
Q
E
E
A
I
P
V
A
I
---
T
--
G
--
R
-
D
I
L
A
R
A
K
N
G
T
G
K
T
A
A
F
V
I
P
---
T
L
E
K
------
V
----
K
-
P
--
K
----------
L
N
K
I
Q
A
--
L
I
M
V
P
T
R
E
L
A
L
Q
T
S
Q
V
V
R
T
L
G
K
H
-
C
------
G
I
S
C
M
V
T
T
G
G
T
N
L
R
-
D
D
-
I
L
R
L
N
E
T
V
------
H
-
I
L
V
G
T
P
G
R
V
L
D
-
L
A
-
S
--
R
K
---
V
A
D
L
S
D
C
S
L
F
I
M
D
E
A
D
K
M
L
S
R
D
F
K
-
T
I
I
E
--
Q
I
L
S
--
F
----
L
------
P
P
T
H
Q
S
--
L
L
F
S
A
T
-----
F
P
L
T
V
D
E
F
M
D
K
H
L
------
H
----
K
----
P
----
Y
-
E
---
I
N
L
--
M
--
E
E
L-
T
L
K
-
G
I
T
Q
Y
Y
A
F
V
-
E
-
E
-
R
-
Q
K
L
H
C
L
N
T
L
F
------------
S
-
K
L
Q
I
N
Q
-
A
I
I
F
C
N
S
T
N
R
V
E
L
L
-
A
K
K
I
T
D
L
-
G
Y
S
C
Y
Y
S
H
A
R
M
K
Q
Q
E
R
N
K
V
F
H
E
F
R
Q
G
K
V
R
T
L
V
C
S
D
L
L
T
R
G
I
D
I
Q
A
V
N
V
V
I
N
F
D
F
P
------
K
T
A
E
T
Y
L
H
R
I
G
R
S
G
R
F
G
H
L
G
L
A
I
N
L
I
----------------------------
94
HHSearch
69.60
29%
15
- C3 -
-
4LJY
3
PRP5_YEAST
A:
[56-428]
---
G
L
S
T
D
T
M
V
L
I
T
E
K
L
H
F
G
S
-----
L
T
P
I
Q
S
Q
A
L
P
A
I
M
---
S
--
G
--
R
-
D
V
I
G
I
S
K
T
G
S
G
K
T
I
S
Y
L
L
P
---
L
L
R
Q
------
V
----
K
-
A
--
Q
RPLSKHE---
T
G
P
-
M
G
--
L
I
L
A
P
T
R
E
L
A
L
Q
I
H
E
E
V
T
K
F
T
E
A
D
T
------
S
I
R
S
V
C
C
T
G
G
S
E
M
K
-
K
Q
-
I
T
D
L
K
R
G
T
------
E
-
I
V
V
A
T
P
G
R
F
I
D
-
I
L
-
T
--
L
N
DGK
L
L
S
T
K
R
I
T
F
V
V
M
D
E
A
D
R
L
F
D
L
G
F
E
-
P
Q
I
T
--
Q
I
M
K
--
T
----
V
------
R
P
D
K
Q
C
--
V
L
F
S
A
T
-----
F
P
N
K
----
L
R
S
F
A
V
R
V
L--
H
----
S
----
P
----
I
-
S
---
I
T
I
--
N
--
S
K
GM
V
N
E
-
N
V
K
Q
K
F
R
I
C
-
H
S
E
-
D
-
E
K
F
D
N
L
V
Q
L
I
H
E
R
S
E
F
F
D
E
V
Q
S-----
D
A
K
-
A
I
I
F
V
S
S
Q
N
I
C
D
F
I
-
S
K
K
L
L
N
A
-
G
I
V
T
C
A
I
H
A
G
K
P
Y
Q
E
R
L
M
N
L
E
K
F
K
R
E
K
N
S
I
L
L
C
T
E
V
L
S
R
G
L
N
V
P
E
V
S
L
V
I
I
Y
N
A
V
------
K
T
F
A
Q
Y
V
H
T
T
G
R
T
A
R
G
S
R
S
G
T
A
I
T
L
L
L
H
D
E
------------------------
6
PsiBlast_PDB
68.50
29%
-14
- C2 -
-
4BRU
-
DHH1_YEAST
A:
[63-387]
---------------
E
A
G
F
E
K
-----
P
S
P
I
Q
E
E
A
I
P
V
A
I
---
T
--
G
--
R
-
D
I
L
A
R
A
K
N
G
T
G
K
T
A
A
F
V
I
P
---
T
L
E
K
------
V
----
K
-
P
--
K
----------
L
N
K
I
Q
A
--
L
I
M
V
P
T
R
E
L
A
L
Q
T
S
Q
V
V
R
T
L
G
K
H
-
C
------
G
I
S
C
M
V
T
T
G
G
T
N
L
R
-
D
D
-
I
L
R
L
N
E
T
V
------
H
-
I
L
V
G
T
P
G
R
V
L
D
-
L
A
-
S
--
R
K
---
V
A
D
L
S
D
C
S
L
F
I
M
D
E
A
D
K
M
L
S
R
D
F
K
-
T
I
I
E
--
Q
I
L
S
--
F
----
L
------
P
P
T
H
Q
S
--
L
L
F
S
A
T
-----
F
P
L
T
V
D
E
F
M
D
K
H
L
------
H
----
K
----
P
----
Y
-
E
---
I
N
L
--
M
--
E
E
L-
T
L
K
-
G
I
T
Q
Y
Y
A
F
V
-
E
-
E
-
R
-
Q
K
L
H
C
L
N
T
L
F
------------
S
-
K
L
Q
I
N
Q
-
A
I
I
F
C
N
S
T
N
R
V
E
L
L
-
A
K
K
I
T
D
L
-
G
Y
S
C
Y
Y
S
H
A
R
M
K
Q
Q
E
R
N
K
V
F
H
E
F
R
Q
G
K
V
R
T
L
V
C
S
D
L
L
T
R
G
I
D
I
Q
A
V
N
V
V
I
N
F
D
F
P
------
K
T
A
E
T
Y
L
H
R
I
G
R
S
G
R
F
G
H
L
G
L
A
I
N
L
I
----------------------------
28
PsiBlast_CBE
68.30
31%
5
- C2 -
-
3G0H
3
DD19B_HUMAN
A:
[59-392]
----------------
M
G
F
N
R
-----
P
S
K
I
Q
E
N
A
L
P
L
M
L
---
A
EP
P
--
Q
-
N
L
I
A
Q
S
Q
S
G
T
G
K
T
A
A
F
V
L
A
---
M
L
S
Q
------
V
----
E
P
A
--
N
----------
K
Y
P
-
Q
C
--
L
C
L
S
P
T
Y
E
L
A
L
Q
T
G
K
V
I
E
Q
M
G
K
----------
F
Y
P
E
L
K
L
A
Y
A
V
R
G
-
N
K
-
L
E
R
G
Q
K
I
S
------
E
Q
I
V
I
G
T
P
G
T
V
L
D
-
W
C
S
K
--
L
K
---
F
I
D
P
K
K
I
K
V
F
V
L
D
E
A
D
V
M
I
A
-
T
Q
G
-
H
Q
D
Q
S
I
R
I
Q
R
--
M
----
L
------
P
R
N
C
Q
M
--
L
L
F
S
A
T
FE
D
S
V
W
K
F
A
----
Q
-
K
V
V
------
P
----
D
----
P
----
N
-
V
---
I
K
L
K
R
E
--
E
E
--
T
L
D
-
T
I
K
Q
Y
Y
V
L
C
-
S
-
S
-
R
D
E
K
F
Q
A
L
C
N
L
Y------------
G
-
A
I
T
I
A
Q
-
A
M
I
F
C
H
T
R
K
T
A
S
W
L
-
A
A
E
L
S
K
E
-
G
H
Q
V
A
L
L
S
G
E
M
M
V
E
Q
R
A
A
V
I
E
R
F
R
E
G
K
E
K
V
L
V
T
T
N
V
C
A
R
G
I
D
V
E
Q
V
S
V
V
I
N
F
D
L
P
VDKDGN
P
D
N
E
T
Y
L
H
R
I
G
R
T
G
R
F
G
K
R
G
L
A
V
N
M
V
----------------------------
100
HHSearch
68.14
29%
16
- C3 -
-
4W7S
6
PRP28_YEAST
A:
[63-420]
-----------
I
I
-
Q
E
L
R
F
P
S
-----
P
T
P
I
Q
R
I
T
I
P
N
V
C
NMK
Q
--
Y
--
R
-
D
F
L
G
V
A
S
T
G
S
G
K
T
L
A
F
V
I
P
---
I
L
I
K
------
M
----
S
-
R
--
S
PPRP
P
S
L
K
I
I
D
G
P
-
K
A
--
L
I
L
A
P
T
R
E
L
V
Q
Q
I
Q
K
E
T
Q
K
V
T
K
I
-
W
S
K
E
SNY
D
C
K
V
I
S
I
V
G
G
H
S
L
E
-
E
I
-
S
F
S
L
S
E
G
C
------
D
-
I
L
V
A
T
P
G
R
L
I
D
-
S
L
-
E
--
N
H
---
L
L
V
M
K
Q
V
E
T
L
V
L
D
E
A
D
K
M
I
D
L
G
F
E
-
D
Q
V
T
--
N
I
L
T
--
K
----
V
D
I
N
ADS
A
V
N
R
Q
T
--
L
M
F
T
A
T
-----
M
T
P
V
----
I
E
K
I
A
------
A
G
YMQ
K
----
P
----
V
-
Y
---
A
T
I
G
V
E
--
T
G
--
S
E
P
-
L
I
Q
Q
V
V
E
Y
A
-
D
N
D
-
E
-
D
K
F
K
K
L
K
P
I
-------------
V
-
A
K
Y
D
P
P
-
I
I
I
F
I
N
Y
K
Q
T
A
D
W
L
-
A
E
K
F
Q
K
E
T
N
M
K
V
T
I
L
H
G
S
K
S
Q
E
Q
R
E
H
S
L
Q
L
F
R
T
N
K
V
Q
I
M
I
A
T
N
V
A
A
R
G
L
D
I
P
N
V
S
L
V
V
N
F
Q
I
S
------
K
K
M
D
D
Y
I
H
R
I
G
R
T
G
R
A
A
N
E
G
T
A
V
S
F
V
S
A
A
E
------------------------
3
PsiBlast_PDB
68.06
31%
2
- C2 -
-
4CT4
-
DDX6_HUMAN
B:
[22-349]
---------------
E
M
G
W
E
K
-----
P
S
P
I
Q
E
E
S
I
P
I
A
L
---
S
--
G
--
R
-
D
I
L
A
R
A
K
N
G
T
G
K
S
G
A
Y
L
I
P
---
L
L
E
R
------
L
----
D
-
L
--
K
----------
K
D
N
I
Q
A
--
M
V
I
V
P
T
R
E
L
A
L
Q
V
S
Q
I
C
I
Q
V
S
K
H
-
M
------
G
G
A
K
V
M
A
T
T
G
G
T
N
L
-
R
D
D
I
M
R
L
D
D
T
V
------
H
-
V
V
I
A
T
P
G
R
I
L
D
-
L
I
-
K
--
K
G
---
V
A
K
V
D
H
V
Q
M
I
V
L
D
E
A
D
K
L
L
S
Q
D
F
V
-
Q
I
M
E
--
D
I
I
L
--
T
----
L
------
P
K
N
R
Q
I
--
L
L
Y
S
A
T
-----
F
P
L
S
----
V
Q
K
F
M
------
N
----
S
HLQK
P
----
Y
-
E
---
I
N
L
--
M
--
E
E
L-
T
L
K
-
G
V
T
Q
Y
Y
A
Y
V
-
T
-
E
-
R
-
Q
K
V
H
C
L
N
T
L
F
------------
S
-
R
L
Q
I
N
Q
-
S
I
I
F
C
N
S
S
Q
R
V
E
L
L
-
A
K
K
I
S
Q
L
-
G
Y
S
C
F
Y
I
H
A
K
M
R
Q
E
H
R
N
R
V
F
H
D
F
R
N
G
L
C
R
N
L
V
C
T
D
L
F
T
R
G
I
D
I
Q
A
V
N
V
V
I
N
F
D
F
P
------
K
L
A
E
T
Y
L
H
R
I
G
R
S
G
R
F
G
H
L
G
L
A
I
N
L
I
T
Y
--------------------------
4
PsiBlast_PDB
67.93
31%
-2
- C2 -
-
4CT5
-
DDX6_HUMAN
A:
[22-349]
---------------
E
M
G
W
E
K
-----
P
S
P
I
Q
E
E
S
I
P
I
A
L
---
S
--
G
--
R
-
D
I
L
A
R
A
K
N
G
T
G
K
S
G
A
Y
L
I
P
---
L
L
E
R
------
L
----
D
-
L
--
K
----------
K
D
N
I
Q
A
--
M
V
I
V
P
T
R
E
L
A
L
Q
V
S
Q
I
C
I
Q
V
S
K
H
-
M
------
G
G
A
K
V
M
A
T
T
G
G
T
N
L
-
R
D
D
I
M
R
L
D
D
T
V
------
H
-
V
V
I
A
T
P
G
R
I
L
D
-
L
I
-
K
--
K
G
---
V
A
K
V
D
H
V
Q
M
I
V
L
D
E
A
D
K
L
L
S
Q
D
F
V
-
Q
I
M
E
--
D
I
I
L
--
T
----
L
------
P
K
N
R
Q
I
--
L
L
Y
S
A
T
-----
F
P
L
S
----
V
Q
K
F
M
------
N
----
S
HLQK
P
----
Y
-
E
---
I
N
L
--
M
--
E
E
L-
T
L
K
-
G
V
T
Q
Y
Y
A
Y
V
-
T
-
E
-
R
-
Q
K
V
H
C
L
N
T
L
F
------------
S
-
R
L
Q
I
N
Q
-
S
I
I
F
C
N
S
S
Q
R
V
E
L
L
-
A
K
K
I
S
Q
L
-
G
Y
S
C
F
Y
I
H
A
K
M
R
Q
E
H
R
N
R
V
F
H
D
F
R
N
G
L
C
R
N
L
V
C
T
D
L
F
T
R
G
I
D
I
Q
A
V
N
V
V
I
N
F
D
F
P
------
K
L
A
E
T
Y
L
H
R
I
G
R
S
G
R
F
G
H
L
G
L
A
I
N
L
I
T
Y
--------------------------
27
PsiBlast_CBE
67.92
31%
2
- C2 -
-
3FHT
3
DD19B_HUMAN
A:
[43-376]
----------------
M
G
F
N
R
-----
P
S
K
I
Q
E
N
A
L
P
L
M
L
---
A
EP
P
--
Q
-
N
L
I
A
Q
S
Q
S
G
T
G
K
T
A
A
F
V
L
A
---
M
L
S
Q
------
V
----
E
P
A
--
N
----------
K
Y
P
-
Q
C
--
L
C
L
S
P
T
Y
E
L
A
L
Q
T
G
K
V
I
E
Q
M
G
K
----------
F
Y
P
E
L
K
L
A
Y
A
V
R
G
-
N
K
-
L
E
R
G
Q
K
I
S
------
E
Q
I
V
I
G
T
P
G
T
V
L
D
-
W
C
S
K
--
L
K
---
F
I
D
P
K
K
I
K
V
F
V
L
D
E
A
D
V
M
I
A
-
T
Q
G
-
H
Q
D
Q
S
I
R
I
Q
R
--
M
----
L
------
P
R
N
C
Q
M
--
L
L
F
S
A
T
FE
D
S
V
W
K
F
A
----
Q
-
K
V
V
------
P
----
D
----
P
----
N
-
V
---
I
K
L
K
R
E
--
E
E
--
T
L
D
-
T
I
K
Q
Y
Y
V
L
C
-
S
-
S
-
R
D
E
K
F
Q
A
L
C
N
L
Y------------
G
-
A
I
T
I
A
Q
-
A
M
I
F
C
H
T
R
K
T
A
S
W
L
-
A
A
E
L
S
K
E
-
G
H
Q
V
A
L
L
S
G
E
M
M
V
E
Q
R
A
A
V
I
E
R
F
R
E
G
K
E
K
V
L
V
T
T
N
V
C
A
R
G
I
D
V
E
Q
V
S
V
V
I
N
F
D
L
P
VDKDGN
P
D
N
E
T
Y
L
H
R
I
G
R
T
G
R
F
G
K
R
G
L
A
V
N
M
V
----------------------------
8
PsiBlast_PDB
67.45
29%
-3
- C2 -
-
1S2M
-
DHH1_YEAST
A:
[63-387]
---------------
E
A
G
F
E
K
-----
P
S
P
I
Q
E
E
A
I
P
V
A
I
---
T
--
G
--
R
-
D
I
L
A
R
A
K
N
G
T
G
K
T
A
A
F
V
I
P
---
T
L
E
K
------
V
----
K
-
P
--
K
----------
L
N
K
I
Q
A
--
L
I
M
V
P
T
R
E
L
A
L
Q
T
S
Q
V
V
R
T
L
G
K
H
-
C
------
G
I
S
C
M
V
T
T
G
G
T
N
L
R
-
D
D
-
I
L
R
L
N
E
T
V
------
H
-
I
L
V
G
T
P
G
R
V
L
D
-
L
A
-
S
--
R
K
---
V
A
D
L
S
D
C
S
L
F
I
M
D
E
A
D
K
M
L
S
R
D
F
K
-
T
I
I
E
--
Q
I
L
S
--
F
----
L
------
P
P
T
H
Q
S
--
L
L
F
S
A
T
-----
F
P
L
T
V
---
K
E
F
M
V
------
K
----
H
----
L
----
H
-
K
PYE
I
N
L
--
M
--
E
E
L-
T
L
K
-
G
I
T
Q
Y
Y
A
F
V
-
E
-
E
-
R
-
Q
K
L
H
C
L
N
T
L
F
------------
S
-
K
L
Q
I
N
Q
-
A
I
I
F
C
N
S
T
N
R
V
E
L
L
-
A
K
K
I
T
D
L
-
G
Y
S
C
Y
Y
S
H
A
R
M
K
Q
Q
E
R
N
K
V
F
H
E
F
R
Q
G
K
V
R
T
L
V
C
S
D
L
L
T
R
G
I
D
I
Q
A
V
N
V
V
I
N
F
D
F
P
------
K
T
A
E
T
Y
L
H
R
I
G
R
S
G
R
F
G
H
L
G
L
A
I
N
L
I
----------------------------
11
PsiBlast_PDB
66.98
31%
12
- C2 -
-
3RRN
2
DBP5_YEAST
A:
[23-353]
----------------
M
K
F
Q
K
-----
P
S
K
I
Q
E
R
A
L
P
L
L
L
---
H
--
N
P
P
R
-
N
M
I
A
Q
S
Q
S
G
T
G
K
T
A
A
F
S
L
T
---
M
L
T
R
------
V
----
N
-
P
--
E
----------
D
A
S
P
Q
A
--
I
C
L
A
P
S
R
E
L
A
R
Q
T
L
E
V
V
Q
E
M
G
K
F
-
T
------
K
I
T
S
Q
L
I
V
P
D
S
F
E
K
N
K
Q
-
I
N
-----
A
------
Q
-
V
I
V
G
T
P
G
T
V
L
D
-
L
M
-
R
--
R
K
---
L
M
Q
L
Q
K
I
K
I
F
V
L
D
E
A
D
N
M
L
D
Q
Q
G
L
G
D
Q
C
I
--
R
V
K
R
--
F
----
L
------
P
K
D
T
Q
L
--
V
L
F
S
A
T
FA
D
A
-
V
R
Q
Y
----
A
K
K
I
V
------
P
----
N
----
A
----
N
-
T
---
L
E
L
Q----------
D
-
A
I
K
Q
L
Y
M
D
C
K
N
-
E
-
A
-
D
K
F
D
V
L
T
E
L
-------------
Y
-
G
V
M
T
I
G
-
S
S
I
I
F
V
A
T
K
K
T
A
N
V
L
Y
G
K
L
K
S
E
-
G
H
E
V
S
I
L
H
G
D
L
Q
T
Q
E
R
D
R
L
I
D
D
F
R
E
G
R
S
K
V
L
I
T
T
N
V
L
A
R
G
I
D
I
P
T
V
S
M
V
V
N
Y
D
L
P
TLANGQ
A
D
P
A
T
Y
I
H
R
I
G
R
T
G
R
F
G
R
K
G
V
A
I
S
F
V
----------------------------
107
HHSearch
66.77
26%
-13
- C2 -
-
2J0U
-
IF4A3_HUMAN
A:
[5-356]
-
T
M
G
L
R
E
D
L
L
R
G
I
-
Y
A
Y
G
F
E
K
-----
P
S
A
I
Q
Q
R
A
I
K
Q
I
I
---
K
--
G
--
R
-
D
V
I
A
Q
S
Q
S
G
T
G
K
T
A
T
F
S
V
S
---
V
L
Q
C
------
L
----
D
-
I
--
Q
V---------
R
E
T
-
Q
A
--
L
I
L
A
P
T
R
E
L
A
V
Q
V
Q
K
G
L
L
A
L
G
D
Y
-
M
------
N
V
Q
C
H
A
C
I
G
G
T
N
V
G
-
E
D
-
I
R
K
L
D
Y
G
Q
------
H
-
V
V
A
G
T
P
G
R
V
F
D
-
M
I
-
R
--
R
R
---
S
L
R
T
R
A
I
K
M
L
V
L
D
E
A
D
E
M
L
N
K
G
F
K
-
E
Q
I
Y
--
D
V
Y
R
--
Y
----
L
------
P
P
A
T
Q
V
--
V
L
I
S
A
T
-----
L
P
H
E
----
I
L
E
M
T
------
N
----
K
----
F
MTD
P
I
-
R
---
I
L
V
--
K
--
R
D
E
L
T
L
E
-
G
I
K
Q
F
F
V
A
V
-
E
-
R
E
E
-
W
K
F
D
T
L
C
D
L
-------------
Y
D---
I
T
Q
-
A
V
I
F
C
N
T
K
R
K
V
D
W
L
-
T
E
K
M
R
E
A
-
N
F
T
V
S
S
M
H
G
D
M
P
Q
K
E
R
E
S
I
M
K
E
F
R
S
G
A
S
R
V
L
I
S
T
D
V
W
A
R
--
D
V
P
Q
V
S
L
I
I
N
Y
D
L
P
------
N
N
R
E
L
Y
I
H
R
I
G
R
S
G
R
Y
G
R
K
G
V
A
V
N
F
V
K
N
D
D
-
I
R
V
L
R
D
I
E
---------------
9
PsiBlast_PDB
65.55
31%
17
- C2 -
-
3PEW
2
DBP5_YEAST
A:
[23-353]
----------------
M
K
F
Q
K
-----
P
S
K
I
Q
E
R
A
L
P
L
L
L
---
H
--
N
P
P
R
-
N
M
I
A
Q
S
Q
S
G
T
G
K
T
A
A
F
S
L
T
---
M
L
T
R
------
V
----
N
-
P
--
E
----------
D
A
S
P
Q
A
--
I
C
L
A
P
S
R
E
L
A
R
Q
T
L
E
V
V
Q
E
M
G
K
F
-
T
------
K
I
T
S
Q
L
I
V
P
D
S
F
E
K
N
K
Q
-
I
N
-----
A
------
Q
-
V
I
V
G
T
P
G
T
V
L
D
-
L
M
-
R
--
R
K
---
L
M
Q
L
Q
K
I
K
I
F
V
L
D
E
A
D
N
M
L
D
Q
Q
G
L
G
D
Q
C
I
--
R
V
K
R
--
F
----
L
------
P
K
D
T
Q
L
--
V
L
F
S
A
T
FA
D
A
-
V
R
Q
Y
----
A
K
K
I
V
------
P
----
N
----
A
----
N
-
T
---
L
E
L
Q
T
N
--
E
V
--
N
V
D
-
A
I
K
Q
L
Y
M
D
C
K
N
-
E
-
A
-
D
K
F
D
V
L
T
E
L
-------------
Y
-
G
V
M
T
I
G
-
S
S
I
I
F
V
A
T
K
K
T
A
N
V
L
Y
G
K
L
K
S
E
-
G
H
E
V
S
I
L
H
G
D
L
Q
T
Q
E
R
D
R
L
I
D
D
F
R
E
G
R
S
K
V
L
I
T
T
N
V
L
A
R
G
I
D
I
P
T
V
S
M
V
V
N
Y
D
L
P
TLANGQ
A
D
P
A
T
Y
I
H
R
I
G
R
T
G
R
F
G
R
K
G
V
A
I
S
F
V
----------------------------
12
PsiBlast_PDB
65.47
31%
13
- C2 -
-
3PEY
3
DBP5_YEAST
A:
[23-353]
----------------
M
K
F
Q
K
-----
P
S
K
I
Q
E
R
A
L
P
L
L
L
---
H
--
N
P
P
R
-
N
M
I
A
Q
S
Q
S
G
T
G
K
T
A
A
F
S
L
T
---
M
L
T
R
------
V
----
N
-
P
--
E
----------
D
A
S
P
Q
A
--
I
C
L
A
P
S
R
E
L
A
R
Q
T
L
E
V
V
Q
E
M
G
K
F
-
T
------
K
I
T
S
Q
L
I
V
P
D
S
F
E
K
N
K
Q
-
I
N
-----
A
------
Q
-
V
I
V
G
T
P
G
T
V
L
D
-
L
M
-
R
--
R
K
---
L
M
Q
L
Q
K
I
K
I
F
V
L
D
E
A
D
N
M
L
D
Q
Q
G
L
G
D
Q
C
I
--
R
V
K
R
--
F
----
L
------
P
K
D
T
Q
L
--
V
L
F
S
A
T
FA
D
A
-
V
R
Q
Y
----
A
K
K
I
V
------
P
----
N
----
A
----
N
-
T
---
L
E
L
QT
N
--
E
V
--
N
V
D
-
A
I
K
Q
L
Y
M
D
C
K
N
-
E
-
A
-
D
K
F
D
V
L
T
E
L
-------------
Y
-
G
L
M
T
I
G
-
S
S
I
I
F
V
A
T
K
K
T
A
N
V
L
Y
G
K
L
K
S
E
-
G
H
E
V
S
I
L
H
G
D
L
Q
T
Q
E
R
D
R
L
I
D
D
F
R
E
G
R
S
K
V
L
I
T
T
N
V
L
A
R
G
I
D
I
P
T
V
S
M
V
V
N
Y
D
L
P
TLANGQ
A
D
P
A
T
Y
I
H
R
I
G
R
T
G
R
F
G
R
K
G
V
A
I
S
F
V
----------------------------
26
PsiBlast_CBE
65.32
31%
6
- C2 -
-
3FHT
5
DD19B_HUMAN
B:
[43-376]
----------------
M
G
F
N
R
-----
P
S
K
I
Q
E
N
A
L
P
L
M
L
---
A
EP
P
--
Q
-
N
L
I
A
Q
S
Q
S
G
T
G
K
T
A
A
F
V
L
A
---
M
L
S
Q
------
V
----
E
P
A
--
N
----------
K
Y
P
-
Q
C
--
L
C
L
S
P
T
Y
E
L
A
L
Q
T
G
K
V
I
E
Q
M
G
K
----------
F
Y
P
E
L
K
L
A
Y
A
V
R
G
-
N
-------
K
I
S
------
E
Q
I
V
I
G
T
P
G
T
V
L
D
-
W
C
S
K
--
L
K
---
F
I
D
P
K
K
I
K
V
F
V
L
D
E
A
D
V
M
I
A
-
T
Q
G
-
H
Q
D
Q
S
I
R
I
Q
R
--
M
----
L
------
P
R
N
C
Q
M
--
L
L
F
S
A
T
FE
D
S
V
W
K
F
A
----
Q
-
K
V
V
------
P
----
D
----
P
----
N
-
V
---
I
K
L
K
R
E
--
E
E
--
T
L
D
-
T
I
K
Q
Y
Y
V
L
C
-
S
-
S
-
R
D
E
K
F
Q
A
L
C
N
L
Y------------
G
-
A
I
T
I
A
Q
-
A
M
I
F
C
H
T
R
K
T
A
S
W
L
-
A
A
E
L
S
K
E
-
G
H
Q
V
A
L
L
S
G
E
M
M
V
E
Q
R
A
A
V
I
E
R
F
R
E
G
K
E
K
V
L
V
T
T
N
V
C
A
R
G
I
D
V
E
Q
V
S
V
V
I
N
F
D
L
P
VDKDGN
P
D
N
E
T
Y
L
H
R
I
G
R
T
G
R
F
G
K
R
G
L
A
V
N
M
V
----------------------------
32
PsiBlast_CBE
55.32
32%
-7
- C2 -
-
3FE2
1
DDX5_HUMAN
A:
[33-216]
-
E
A
N
F
P
A
N
V
M
D
V
I
-
A
R
Q
N
F
T
E
-----
P
T
A
I
Q
A
Q
G
W
P
V
A
L
---
S
--
G
--
L
-
D
M
V
G
V
A
Q
T
G
S
G
K
T
L
S
Y
L
L
P
---
A
I
V
H
I
N
H
Q
PF
L
----
E
-
R
--
G
----------
D
G
P
-
I
C
--
L
V
L
A
P
T
R
E
L
A
Q
Q
V
Q
Q
V
A
A
E
Y
C
R
A
-
C
------
R
L
K
S
T
C
I
Y
G
G
A
P
K
G
-
P
Q
-
I
R
D
L
E
R
G
V
------
E
-
I
C
I
A
T
P
G
R
L
I
D
-
F
L
-
E
--
C
G
---
K
T
N
L
R
R
T
T
Y
L
V
L
D
E
A
D
R
M
L
D
M
G
F
E
-
P
Q
I
R
--
K
I
V
D
--
Q
----
I
------
R
P
D
R
Q
T
--
L
M
W
S
A
T
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
31
PsiBlast_CBE
53.23
32%
-3
- C2 -
-
3FE2
1
DDX5_HUMAN
B:
[33-216]
-
E
A
N
F
P
A
N
V
M
D
V
I
-
A
R
Q
N
F
T
E
-----
P
T
A
I
Q
A
Q
G
W
P
V
A
L
---
S
--
G
--
L
-
D
M
V
G
V
A
Q
T
G
S
G
K
T
L
S
Y
L
L
P
---
A
I
V
H
INHQPF
L
----
E
-
R
--
G
----------
D
G
P
-
I
C
--
L
V
L
A
P
T
R
E
L
A
Q
Q
V
Q
Q
V
A
A
E
Y
C
R
A
-
C
------
R
L
K
S
T
C
I
Y
G
G
A
P
K
G
-
P
Q
-
I
R
D
L
E
R
G
V
------
E
-
I
C
I
A
T
P
G
R
L
I
D
-
F
L
-
E
--
C
G
---
K
T
N
L
R
R
T
T
Y
L
V
L
D
E
A
D
R
M
L
D
M
G
F
E
-
P
Q
I
R
--
K
I
V
D
--
Q
----
I
------
R
P
D
R
Q
T
--
L
M
W
S
A
T
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
46
PsiBlast_CBE
47.44
31%
-14
- C2 -
-
2GXS
2
?
B:
[20-184]
-----------------
G
L
T
T
-----
P
T
P
I
Q
A
A
A
L
P
L
A
L
---
E
--
G
--
K
-
D
L
I
G
Q
A
R
T
G
T
G
K
T
L
A
F
A
L
P
---
I
A
E
R
------
L
APSQ
E
-
R
--
G
----------
R
K
P
-
R
A
--
L
V
L
T
P
T
R
E
L
A
L
Q
V
A
S
E
L
T
A
V
A
P
H
-
L
------
K
V
V
A
--
V
Y
G
G
T
G
Y
G
-
K
Q
-
K
E
A
L
L
R
G
A
------
D
-
A
V
V
A
T
P
G
R
A
L
D
-
Y
L
-
R
--
Q
G
---
V
L
D
L
S
R
V
E
V
A
V
L
D
E
A
D
E
M
L
S
M
G
F
E
-
E
E
V
E
--
A
L
L
S
--
A
----
T
------
P
P
S
R
Q
T
--
L
L
F
S
A
T
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
47
PsiBlast_CBE
46.87
31%
-16
- C2 -
-
2GXS
1
?
A:
[20-184]
-----------------
G
L
T
T
-----
P
T
P
I
Q
A
A
A
L
P
L
A
L
---
E
--
G
--
K
-
D
L
I
G
Q
A
R
T
G
T
G
K
T
L
A
F
A
L
P
---
I
A
E
R
------
L
APSQ
E
-
R
--
G
----------
R
K
P
-
R
A
--
L
V
L
T
P
T
R
E
L
A
L
Q
V
A
S
E
L
T
A
V
A
P
H
-
L
------
K
V
V
A
--
V
Y
G
G
T
G
Y
G
-
K
Q
-
K
E
A
L
L
R
G
A
------
D
-
A
V
V
A
T
P
G
R
A
L
D
-
Y
L
-
R
--
Q
G
---
V
L
D
L
S
R
V
E
V
A
V
L
D
E
A
D
E
M
L
S
M
G
F
E
-
E
E
V
E
--
A
L
L
S
--
A
----
T
------
P
P
S
R
Q
T
--
L
L
F
S
A
T
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
48
PsiBlast_CBE
46.81
31%
-20
- C2 -
-
2GXQ
1
?
A:
[20-184]
-----------------
G
L
T
T
-----
P
T
P
I
Q
A
A
A
L
P
L
A
L
---
E
--
G
--
K
-
D
L
I
G
Q
A
R
T
G
T
G
K
T
L
A
F
A
L
P
---
I
A
E
R
------
L
APSQ
E
-
R
--
G
----------
R
K
P
-
R
A
--
L
V
L
T
P
T
R
E
L
A
L
Q
V
A
S
E
L
T
A
V
A
P
H
-
L
------
K
V
V
A
--
V
Y
G
G
T
G
Y
G
-
K
Q
-
K
E
A
L
L
R
G
A
------
D
-
A
V
V
A
T
P
G
R
A
L
D
-
Y
L
-
R
--
Q
G
---
V
L
D
L
S
R
V
E
V
A
V
L
D
E
A
D
E
M
L
S
M
G
F
E
-
E
E
V
E
--
A
L
L
S
--
A
----
T
------
P
P
S
R
Q
T
--
L
L
F
S
A
T
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
44
PsiBlast_CBE
42.72
32%
-11
- C2 -
-
3DKP
3
DDX52_HUMAN
A:
[48-226]
-----------------
G
F
Q
M
-----
P
T
P
I
Q
M
Q
A
I
P
V
M
L
---
H
--
G
--
R
-
E
L
L
A
S
A
P
T
G
S
G
K
T
L
A
F
S
I
P
---
I
L
M
Q
------
L
----
K
-
Q
PA
N
----------
K
G
F
-
R
A
--
L
I
I
S
P
T
R
E
L
A
S
Q
I
H
R
E
L
I
K
I
S
E
G
-
T
------
G
F
R
I
H
M
I
-----
H
K
-
A
A
-
V
A
A
K
K
F
G
P
KSSKKF
D
-
I
L
V
T
T
P
N
R
L
I
Y
-
L
L
-
K
QD
P
P
---
G
I
D
L
A
S
V
E
W
L
V
V
D
E
S
D
K
L
F
E
D
G
---
G
F
R
D
--
Q
L
A
S
I
F
L
----
A
------
C
T
S
H
K
V
R
R
A
M
F
S
A
T
-----
F
A
Y
D
----
V
E
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
43
PsiBlast_CBE
42.17
32%
6
- C2 -
-
2PL3
4
DDX10_HUMAN
A:
[39-211]
-----------------
G
L
Q
E
A
QYRL
V
T
E
I
Q
K
Q
T
I
G
L
A
L
---
Q
--
G
--
K
-
D
V
L
G
A
A
K
T
G
S
G
K
T
L
A
F
L
V
P
V
L
E
A
L
Y
R
------
L
----
Q
-
W
--
T
----------
S
T
D
-
G
L
G
V
L
I
I
S
P
T
R
E
L
A
Y
Q
T
F
E
V
L
R
K
V
G
K
N
-
H
------
D
F
S
A
G
L
I
I
G
G
--
L
K
-
H
E
-
A
E
R
I
N
N
-
I
------
N
-
I
L
V
C
T
P
G
R
L
L
Q
H
M
D
-
E
--
T
V
---
S
F
H
A
T
D
L
Q
M
L
V
L
D
E
A
D
R
I
L
D
M
G
F
A
-
D
T
M
N
--
A
V
I
E
--
N
----
L
------
P
K
K
R
Q
T
--
L
L
F
S
A
T
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------