@TOME V2.3
(Mar 2018)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : spr1377: (2018-01-10 )
MSKELHINTILAQAGIKSDEATGALVTPLHFSTTYQHPEFGRSTGFDYTRTKNPTRSKAEEVLAAIESADYALATSSGMSAIVLAFSVFPVGSKVLAVRDLYGGSFRWFNQVEQEGRFHFTYANTEEELIAELEKDVDVLYIETPTNPLMLEFDIEKLAKLAHAKGAKVVVDNTFYSPIYQRPIEDGADIVLHSATKYLAGHNDVLAGVVVTNSLELYEKLFYNLNTTGAVLSPFDSYQLLRGLKTLSLRMERSTANAQEVVAFLKDSPAVKEVLYTGRGGMISFKVADETRIPHILNSLKVFSFAESLGGVESLITYPTTQTHADIPAEVRHSYGLTDDLLRLSIGIEDARDLIADLRQALEG
Atome Classification :
(42 SA)
.........10........20.....--...30....--....40-------.--.--------------.------......50........60........70........80-..-..-.-..-.-90........100.......-110...--.--.--.---..120--....--...130---..---.-.....140.......150.......160..--.------....170.......180.......190.......200.......-210--.......-220.--.--.-....230.......240.......250.......260.......270....----------------.------------------.----------------.----------------280.....---.---.290.-..-.....300.......310.......320.......330.......340.......350.......360..
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MSK
E
L
H
I
N
T
I
L
A
QAGIKSDEAT
G
A
L
V
--
T
P
L
H
FSTTY--QHPEF--------G--R--------------S------TGFDYTRTKNP
T
R
S
K
A
E
E
V
L
A
A
I
ESA
D
Y
A
L
ATSSG
M
S
A
-
I
V
-
L
A
-
F
-
S
V-F-PVG
S
K
V
L
A
V
R
DLYGGS
F
R
W
F
-
N
Q
-VEQ--E--G--
R
---
F
H
F
T
Y--AN
T
E
--
E
E
L
I
A
----
E
L
---E-KDV
D
V
L
Y
I
ETPTN
P
L
M
L
E
F
D
I
E
K
L
A
K
L
A
HA--K------G
A
K
V
V
VDNTFY
S
P
I
Y
QRPIEDGA
D
I
V
L
H
S
A
T
K
Y
LAGHN
D
V
L
A
G
V
-
V
VT--
N
S
L
E
L
Y
E
-
K
L
F
Y--N--L-NTTGAVLSP
F
D
S
Y
Q
L
L
R
G
L
K
T
L
S
L
R
MERSTA
N
A
Q
E
V
V
A
F
LKDS
P
A
V
K
E
V
L
Y----------------T------------------G----------------R----------------G
G
M
I
S
F
K
V---A---DE-TR-
I
P
-
H
I
L
N
S
L
K
V
F
S
F
A
E
S
LG
G
V
E
S
L
ITYPTTQTHADI
P
A
E
V
R
H
SYGL
T
D
D
L
L
R
L
SIG
I
E
D
A
R
D
L
I
A
D
L
R
Q
ALEG
3
PsiBlast_PDB
88.70
39%
-23
- C1 -
-
4IY7
7
?
A:
[14-393]
---
A
L
S
L
A
T
L
A
I
H
G
G
Q
S
P
D
P
S
T
G
A
V
M
--
P
P
I
Y
A
T
S
T
Y
--
A
Q
S
S
P
--------
G
--
E
--------------
H
------
Q
G
F
E
Y
S
R
T
H
N
P
T
R
F
A
Y
E
R
C
V
A
A
L
E
G
G
T
R
A
F
A
F
A
S
G
M
A
A
-
T
S
-
T
V
-
M
-
E
L
-
L
-
D
A
G
S
H
V
V
A
M
D
D
L
Y
G
G
T
F
R
L
F
-
E
R
-
V
R
R
--
R
--
T
--
A
G
L
D
F
S
F
V
D
--
L
T
D
P
--
A
A
F
K
A
----
A
I
---
R
-
A
D
T
K
M
V
W
I
E
T
P
T
N
P
M
L
K
L
V
D
I
A
A
I
A
V
I
A
R
K
--
H
------
G
L
L
T
V
V
D
N
T
F
A
S
P
M
L
Q
R
P
L
S
L
G
A
D
L
V
V
H
S
A
T
K
Y
L
N
G
H
S
D
M
V
G
G
I
A
V
V
G
--
D
N
A
E
L
A
E
-
Q
M
A
F
--
L
--
Q
-
N
S
I
G
G
V
Q
G
P
F
D
S
F
L
A
L
R
G
L
K
T
L
P
L
R
M
R
A
H
C
E
N
A
L
A
L
A
Q
W
L
E
T
H
P
A
I
E
K
V
I
Y
PGLASHPQ
H
V
L
A
K
R
Q
M
S
------------------
G
----------------
F
----------------
G
G
I
V
S
I
V
L
---
K
GG
F
D
A
-
A
K
----
R
F
C
E
K
T
E
L
F
T
L
A
E
S
L
G
G
V
E
S
L
V
N
H
P
A
V
M
T
H
A
S
I
P
V
A
R
R
E
Q
L
G
I
S
D
A
L
V
R
L
S
V
G
I
E
D
L
G
D
L
R
G
D
L
E
R
A
L
--
164
HHSearch
88.33
41%
-21
- C1 -
-
4IY7
5
?
D:
[14-395]
---
A
L
S
L
A
T
L
A
I
H
G
G
Q
S
P
D
P
S
T
G
A
V
M
--
P
P
I
Y
A
T
S
T
Y
--
A
Q
S
S
P
--------
G
--
E
--------------
H
------
Q
G
F
E
Y
S
R
T
H
N
P
T
R
F
A
Y
E
R
C
V
A
A
L
E
G
G
T
R
A
F
A
F
A
S
G
M
A
A
-
T
S
-
T
V
-
M
-
E
L
-
L
-
D
A
G
S
H
V
V
A
M
D
D
L
Y
G
G
T
F
R
L
F
-
E
R
-
V
R
R
RT
A
G-
L
--
D
---
F
S
F
V
D
--
L
T
D
P
--
A
A
F
K
A
----
A
I
---
R
-
A
D
T
K
M
V
W
I
E
T
P
T
N
P
M
L
K
L
V
D
I
A
A
I
A
V
I
A
R
K
--
H
------
G
L
L
T
V
V
D
N
T
F
A
S
P
M
L
Q
R
P
L
S
L
G
A
D
L
V
V
H
S
A
T
K
Y
L
N
G
H
S
-
D
M
V
G
G
-
I
A
V
VG
D
N
A
E
L
A
E
-
Q
M
A
F
--
L
--
Q
-
N
S
I
G
G
V
Q
G
P
F
D
S
F
L
A
L
R
G
L
K
T
L
P
L
R
M
R
A
H
C
E
N
A
L
A
L
A
Q
W
L
E
T
H
P
A
I
E
K
V
I
Y
----------------
P
------------------
G
LASHPQHVLAKRQMSG
F
----------------
G
G
I
V
S
I
V
L
---
K
---
G
G
F
D
A
-
A
K
-
R
F
C
E
K
T
E
L
F
T
L
A
E
S
L
G
G
V
E
S
L
V
N
H
P
A
V
M
T
H
A
S
I
P
V
A
R
R
E
Q
L
G
I
S
D
A
L
V
R
L
S
V
G
I
E
D
L
G
D
L
R
G
D
L
E
R
A
L
V
N
28
PsiBlast_CBE
88.20
39%
-23
- C1 -
-
4IY7
5
?
D:
[14-393]
---
A
L
S
L
A
T
L
A
I
H
G
G
Q
S
P
D
P
S
T
G
A
V
M
--
P
P
I
Y
A
T
S
T
Y
--
A
Q
S
S
P
--------
G
--
E
--------------
H
------
Q
G
F
E
Y
S
R
T
H
N
P
T
R
F
A
Y
E
R
C
V
A
A
L
E
G
G
T
R
A
F
A
F
A
S
G
M
A
A
-
T
S
-
T
V
-
M
-
E
L
-
L
-
D
A
G
S
H
V
V
A
M
D
D
L
Y
G
G
T
F
R
L
F
-
E
R
-
V
R
R
--
R
--
T
--
A
GLD
F
S
F
V
D
--
L
T
D
P
--
A
A
F
K
A
----
A
I
---
R
-
A
D
T
K
M
V
W
I
E
T
P
T
N
P
M
L
K
L
V
D
I
A
A
I
A
V
I
A
R
K
--
H
------
G
L
L
T
V
V
D
N
T
F
A
S
P
M
L
Q
R
P
L
S
L
G
A
D
L
V
V
H
S
A
T
K
Y
L
N
G
H
S
D
M
V
G
G
I
A
V
V
G
--
D
N
A
E
L
A
E
-
Q
M
A
F
--
L
--
Q
-
N
S
I
G
G
V
Q
G
P
F
D
S
F
L
A
L
R
G
L
K
T
L
P
L
R
M
R
A
H
C
E
N
A
L
A
L
A
Q
W
L
E
T
H
P
A
I
E
K
V
I
Y
PGLASHPQHVLAKRQM
S
------------------
G
----------------
F
----------------
G
G
I
V
S
I
V
L
---
K
GGF
D
A
-
A
K
----
R
F
C
E
K
T
E
L
F
T
L
A
E
S
L
G
G
V
E
S
L
V
N
H
P
A
V
M
T
H
A
S
I
P
V
A
R
R
E
Q
L
G
I
S
D
A
L
V
R
L
S
V
G
I
E
D
L
G
D
L
R
G
D
L
E
R
A
L
--
30
PsiBlast_CBE
87.84
39%
-23
- C1 -
-
4IY7
5
?
B:
[14-393]
---
A
L
S
L
A
T
L
A
I
H
G
G
Q
S
P
D
P
S
T
G
A
V
M
--
P
P
I
Y
A
T
S
T
Y
--
A
Q
S
S
P
--------
G
--
E
--------------
H
------
Q
G
F
E
Y
S
R
T
H
N
P
T
R
F
A
Y
E
R
C
V
A
A
L
E
G
G
T
R
A
F
A
F
A
S
G
M
A
A
-
T
S
-
T
V
-
M
-
E
L
-
L
-
D
A
G
S
H
V
V
A
M
D
D
L
Y
G
G
T
F
R
L
F
-
E
R
-
V
R
R
--
R
--
T
--
A
GLD
F
S
F
V
D
--
L
T
D
P
--
A
A
F
K
A
----
A
I
---
R
-
A
D
T
K
M
V
W
I
E
T
P
T
N
P
M
L
K
L
V
D
I
A
A
I
A
V
I
A
R
K
--
H
------
G
L
L
T
V
V
D
N
T
F
A
S
P
M
L
Q
R
P
L
S
L
G
A
D
L
V
V
H
S
A
T
K
Y
L
N
G
H
S
D
M
V
G
G
I
A
V
V
G
--
D
N
A
E
L
A
E
-
Q
M
A
F
--
L
--
Q
-
N
S
I
G
G
V
Q
G
P
F
D
S
F
L
A
L
R
G
L
K
T
L
P
L
R
M
R
A
H
C
E
N
A
L
A
L
A
Q
W
L
E
T
H
P
A
I
E
K
V
I
Y
PGLASHPQHVLAKRQM
S
------------------
G
----------------
F
----------------
G
G
I
V
S
I
V
L
---
K
GGF
D
A
-
A
K
----
R
F
C
E
K
T
E
L
F
T
L
A
E
S
L
G
G
V
E
S
L
V
N
H
P
A
V
M
T
H
A
S
I
P
V
A
R
R
E
Q
L
G
I
S
D
A
L
V
R
L
S
V
G
I
E
D
L
G
D
L
R
G
D
L
E
R
A
L
--
4
PsiBlast_PDB
87.16
39%
-22
- C1 -
-
4IYO
7
?
A:
[14-393]
---
A
L
S
L
A
T
L
A
I
H
G
G
Q
S
P
D
P
S
T
G
A
V
M
--
P
P
I
Y
A
T
S
T
Y
--
A
Q
S
S
P
--------
G
--
E
--------------
H
------
Q
G
F
E
Y
S
R
T
H
N
P
T
R
F
A
Y
E
R
C
V
A
A
L
E
G
G
T
R
A
F
A
F
A
S
G
M
A
A
-
T
S
-
T
V
-
M
-
E
L
-
L
-
D
A
G
S
H
V
V
A
M
D
D
L
Y
G
G
T
F
R
L
F
-
E
R
-
V
R
R
--
R
--
T
--
A
G
L
D
F
S
F
V
D
--
L
T
D
P
--
A
A
F
K
A
----
A
I
---
R
-
A
D
T
K
M
V
W
I
E
T
P
T
N
P
M
L
K
L
V
D
I
A
A
I
A
V
I
A
R
K
--
H
------
G
L
L
T
V
V
D
N
T
F
A
S
P
M
L
Q
R
P
L
S
L
G
A
D
L
V
V
H
S
A
T
K
Y
L
N
G
H
S
D
M
V
G
G
I
A
V
V
G
--
D
N
A
E
L
A
E
-
Q
M
A
F
--
L
--
Q
-
N
S
I
G
G
V
Q
G
P
F
D
S
F
L
A
L
R
G
L
K
T
L
P
L
R
M
R
A
H
C
E
N
A
L
A
L
A
Q
W
L
E
T
H
P
A
I
E
K
V
I
Y
PGLASHPQ
H
V
L
A
K
R
Q
M
S
------------------
G
----------------
F
----------------
G
G
I
V
S
I
V
L
---
K
GG
F
D
A
-
A
K
----
R
F
C
E
K
T
E
L
F
T
L
A
E
S
L
G
G
V
E
S
L
V
N
H
P
A
V
M
T
H
A
S
I
P
V
A
R
R
E
Q
L
G
I
S
D
A
L
V
R
L
S
V
G
I
E
D
L
G
D
L
R
G
D
L
E
R
A
L
--
29
PsiBlast_CBE
86.97
39%
-21
- C1 -
-
4IY7
4
?
C:
[14-393]
---
A
L
S
L
A
T
L
A
I
H
G
G
Q
S
P
D
P
S
T
G
A
V
M
--
P
P
I
Y
A
T
S
T
Y
--
A
Q
S
S
P
--------
G
--
E
--------------
H
------
Q
G
F
E
Y
S
R
T
H
N
P
T
R
F
A
Y
E
R
C
V
A
A
L
E
G
G
T
R
A
F
A
F
A
S
G
M
A
A
-
T
S
-
T
V
-
M
-
E
L
-
L
-
D
A
G
S
H
V
V
A
M
D
D
L
Y
G
G
T
F
R
L
F
-
E
R
-
V
R
R
--
R
--
T
--
A
GLD
F
S
F
V
D
--
L
T
D
P
--
A
A
F
K
A
----
A
I
---
R
-
A
D
T
K
M
V
W
I
E
T
P
T
N
P
M
L
K
L
V
D
I
A
A
I
A
V
I
A
R
K
--
H
------
G
L
L
T
V
V
D
N
T
F
A
S
P
M
L
Q
R
P
L
S
L
G
A
D
L
V
V
H
S
A
T
K
Y
L
N
G
H
S
D
M
V
G
G
I
A
V
V
G
--
D
N
A
E
L
A
E
-
Q
M
A
F
--
L
--
Q
-
N
S
I
G
G
V
Q
G
P
F
D
S
F
L
A
L
R
G
L
K
T
L
P
L
R
M
R
A
H
C
E
N
A
L
A
L
A
Q
W
L
E
T
H
P
A
I
E
K
V
I
Y
PGLASHPQHVLAKRQM
S
------------------
G
----------------
F
----------------
G
G
I
V
S
I
V
L
---
K
GGF
D
A
-
A
K
----
R
F
C
E
K
T
E
L
F
T
L
A
E
S
L
G
G
V
E
S
L
V
N
H
P
A
V
M
T
H
A
S
I
P
V
A
R
R
E
Q
L
G
I
S
D
A
L
V
R
L
S
V
G
I
E
D
L
G
D
L
R
G
D
L
E
R
A
L
--
5
PsiBlast_PDB
86.03
39%
-28
- C1 -
-
3E6G
-
?
A:
[14-392]
---
A
L
S
L
A
T
L
A
I
H
G
G
Q
S
P
D
P
S
T
G
A
V
M
--
P
P
I
Y
A
T
S
T
Y
--
A
Q
S
S
-----------------------------------------
T
H
N
P
T
R
F
A
Y
E
R
C
V
A
A
L
E
G
G
T
R
A
F
A
F
A
S
G
M
A
A
-
T
S
-
T
V
-
M
-
E
L
-
L
-
D
A
G
S
H
V
V
A
M
D
D
L
Y
G
G
T
F
R
L
F
-
E
R
-
V
R
R
--
R
--
T
--
A
G
L
D
F
S
F
V
D
--
L
T
D
P
--
A
A
F
K
A
----
A
I
---
R
-
A
D
T
K
M
V
W
I
E
T
P
T
N
P
M
L
K
L
V
D
I
A
A
I
A
V
I
A
R
K
--
H
------
G
L
L
T
V
V
D
N
T
F
A
S
P
M
L
Q
R
P
L
S
L
G
A
D
L
V
V
H
S
A
T
K
Y
L
N
G
H
S
D
M
V
G
G
I
A
V
V
G
--
D
N
A
E
L
A
E
-
Q
M
A
F
--
L
--
Q
-
N
S
I
G
G
V
Q
G
P
F
D
S
F
L
A
L
R
G
L
K
T
L
P
L
R
M
R
A
H
C
E
N
A
L
A
L
A
Q
W
L
E
T
H
P
A
I
E
K
V
I
Y
PGLASHPQ
H
V
L
A
K
R
QM
S
------------------
G
----------------
F
----------------
G
G
I
V
S
I
V
L
---
K
GG
F
D
A
-
A
K
----
R
F
C
E
K
T
E
L
F
T
L
A
E
S
L
G
G
V
E
S
L
V
N
H
P
A
V
M
T
H
A
S
I
P
V
A
R
R
E
Q
L
G
I
S
D
A
L
V
R
L
S
V
G
I
E
D
L
G
D
L
R
G
D
L
E
R
A
---
2
PsiBlast_PDB
86.00
42%
-15
- C1 -
-
1CS1
-
METB_ECOLI
A:
[7-376]
--------
T
I
A
V
R
S
G
L
N
D
D
E
Q
Y
G
C
V
V
--
P
P
I
H
L
S
S
T
Y
--
N
F
T
G
F
--------
N
--
E
--------------
P
------
R
A
H
D
Y
S
R
R
G
N
P
T
R
D
V
V
Q
R
A
L
A
E
L
E
G
G
A
G
A
V
L
T
N
T
G
M
S
A
-
I
H
-
L
V
-
T
-
T
V
-
F
L
K
P
G
D
L
L
V
A
P
H
D
C
Y
G
G
S
Y
R
L
F
-
D
S
-
L
A
K
--
R
--
G
C
Y
R
---
V
L
F
V
D
--
Q
G
D
E
--
Q
A
L
R
A
----
A
L
---
A
-
E
K
P
K
L
V
L
V
E
S
P
S
N
P
L
L
R
V
V
D
I
A
K
I
C
H
L
A
R
E
--
V
------
G
A
V
S
V
V
D
N
T
F
L
S
P
A
L
Q
N
P
L
A
L
G
A
D
L
V
L
H
S
C
T
K
Y
L
N
G
H
S
D
V
V
A
G
V
-
V
I
A
--
K
D
P
D
V
V
T
-
E
L
A
W
--
W
--
A
-
N
N
I
G
V
T
G
G
A
F
D
S
Y
L
L
L
R
G
L
R
T
L
V
P
R
M
E
L
A
Q
R
N
A
Q
A
I
V
K
Y
L
Q
T
Q
P
L
V
K
K
L
Y
H
PSLPENQ
G
H
E
I
A
A
RQQ
K
------------------
G
----------------
F
----------------
G
A
M
L
S
F
E
L
D
--
G
---
D
E
-
Q
T
-
L
R
-
R
F
L
G
G
L
S
L
F
T
L
A
E
S
L
G
G
V
E
S
L
I
S
H
A
A
T
M
T
H
A
G
M
A
P
E
A
R
A
A
A
G
I
S
E
T
L
L
R
I
S
T
G
I
E
D
G
E
D
L
I
A
D
L
------
32
PsiBlast_CBE
85.05
42%
-17
- C1 -
-
1CS1
1
METB_ECOLI
D:
[7-376]
--------
T
I
A
V
R
S
G
L
N
D
D
E
Q
Y
G
C
V
V
--
P
P
I
H
L
S
S
T
Y
--
N
F
T
G
F
--------
N
--
E
--------------
P
------
R
A
H
D
Y
S
R
R
G
N
P
T
R
D
V
V
Q
R
A
L
A
E
L
E
G
G
A
G
A
V
L
T
N
T
G
M
S
A
-
I
H
-
L
V
-
T
-
T
V
-
F
L
K
P
G
D
L
L
V
A
P
H
D
C
Y
G
G
S
Y
R
L
F
-
D
S
-
L
A
K
--
R
--
G
CY
R
---
V
L
F
V
D
--
Q
G
D
E
--
Q
A
L
R
A
----
A
L
---
A
-
E
K
P
K
L
V
L
V
E
S
P
S
N
P
L
L
R
V
V
D
I
A
K
I
C
H
L
A
R
E
--
V
------
G
A
V
S
V
V
D
N
T
F
L
S
P
A
L
Q
N
P
L
A
L
G
A
D
L
V
L
H
S
C
T
K
Y
L
N
G
H
S
D
V
V
A
G
V
-
V
I
A
--
K
D
P
D
V
V
T
-
E
L
A
W
--
W
--
A
-
N
N
I
G
V
T
G
G
A
F
D
S
Y
L
L
L
R
G
L
R
T
L
V
P
R
M
E
L
A
Q
R
N
A
Q
A
I
V
K
Y
L
Q
T
Q
P
L
V
K
K
L
Y
H
PSLPENQGHEIAARQQ
K
------------------
G
----------------
F
----------------
G
A
M
L
S
F
E
L
D--
G
---
D
E
-
Q
T
-
L
R
-
R
F
L
G
G
L
S
L
F
T
L
A
E
S
L
G
G
V
E
S
L
I
S
H
A
A
T
M
T
H
A
G
M
A
P
E
A
R
A
A
A
G
I
S
E
T
L
L
R
I
S
T
G
I
E
D
G
E
D
L
I
A
D
L
------
131
PsiBlast_CBE
84.78
34%
0
- C- -
-
1I48
3
?
B:
[71-443]
--------------
G
I
V
T
D
A
I
T
T
P
V
V
NT
S
A
Y
F
F
N
K
T
S
--
E
L
I
D
F
--------
K
EK
R
--------------
R
------
A
S
F
E
Y
G
R
Y
G
N
P
T
T
V
V
L
E
E
K
I
S
A
L
E
G
A
E
S
T
L
L
M
A
S
G
M
C
A
S
T
V
-
M
L
-
L
-
A
L
-
V
-
P
A
G
G
H
I
V
T
T
T
D
C
Y
R
K
T
R
I
F
I
-
E
T
-
I
L
P
--
K
--
M
--
G
---
I
T
A
T
V
--
I
D
P
A
--
D
V
G
A
L
----
E
L
ALN
Q
-
K
K
V
N
L
F
F
T
E
S
P
T
N
P
F
L
R
C
V
D
I
E
L
V
S
K
L
C
H
E
--
K
------
G
A
L
V
C
I
D
G
T
F
A
T
P
L
N
Q
K
A
L
A
L
G
A
D
L
V
L
H
S
A
T
K
F
L
G
G
H
N
D
V
L
A
G
--
C
I
S
--
G
P
L
K
L
V
S
-
E
I
R
N
--
L
--
H
-
H
I
L
G
G
A
L
N
P
N
A
A
Y
L
I
I
R
G
M
K
T
L
H
L
R
V
Q
Q
Q
N
S
T
A
L
R
M
A
E
I
L
E
A
H
P
K
V
R
H
V
Y
Y
PGLQSHPEHHIAKKQM
T
------------------
G
----------------
F
----------------
G
G
A
V
S
F
E
V
D--
G
---
D
L
-
L
T
-
T
A
-
K
F
V
D
A
L
K
I
P
Y
I
A
P
S
F
G
G
C
E
S
I
V
D
Q
P
A
I
M
S
Y
W
D
L
S
Q
S
D
R
A
K
Y
G
I
M
D
N
L
V
R
F
S
F
G
V
E
D
F
D
D
L
K
A
D
I
L
Q
A
L
D
-
130
PsiBlast_CBE
84.78
34%
0
- C- -
-
1I48
2
?
C:
[71-443]
--------------
G
I
V
T
D
A
I
T
T
P
V
V
NT
S
A
Y
F
F
N
K
T
S
--
E
L
I
D
F
--------
K
EK
R
--------------
R
------
A
S
F
E
Y
G
R
Y
G
N
P
T
T
V
V
L
E
E
K
I
S
A
L
E
G
A
E
S
T
L
L
M
A
S
G
M
C
A
S
T
V
-
M
L
-
L
-
A
L
-
V
-
P
A
G
G
H
I
V
T
T
T
D
C
Y
R
K
T
R
I
F
I
-
E
T
-
I
L
P
--
K
--
M
--
G
---
I
T
A
T
V
--
I
D
P
A
--
D
V
G
A
L
----
E
L
ALN
Q
-
K
K
V
N
L
F
F
T
E
S
P
T
N
P
F
L
R
C
V
D
I
E
L
V
S
K
L
C
H
E
--
K
------
G
A
L
V
C
I
D
G
T
F
A
T
P
L
N
Q
K
A
L
A
L
G
A
D
L
V
L
H
S
A
T
K
F
L
G
G
H
N
D
V
L
A
G
--
C
I
S
--
G
P
L
K
L
V
S
-
E
I
R
N
--
L
--
H
-
H
I
L
G
G
A
L
N
P
N
A
A
Y
L
I
I
R
G
M
K
T
L
H
L
R
V
Q
Q
Q
N
S
T
A
L
R
M
A
E
I
L
E
A
H
P
K
V
R
H
V
Y
Y
PGLQSHPEHHIAKKQM
T
------------------
G
----------------
F
----------------
G
G
A
V
S
F
E
V
D--
G
---
D
L
-
L
T
-
T
A
-
K
F
V
D
A
L
K
I
P
Y
I
A
P
S
F
G
G
C
E
S
I
V
D
Q
P
A
I
M
S
Y
W
D
L
S
Q
S
D
R
A
K
Y
G
I
M
D
N
L
V
R
F
S
F
G
V
E
D
F
D
D
L
K
A
D
I
L
Q
A
L
D
-
129
PsiBlast_CBE
84.78
34%
0
- C- -
-
1I48
2
?
D:
[71-443]
--------------
G
I
V
T
D
A
I
T
T
P
V
V
NT
S
A
Y
F
F
N
K
T
S
--
E
L
I
D
F
--------
K
EK
R
--------------
R
------
A
S
F
E
Y
G
R
Y
G
N
P
T
T
V
V
L
E
E
K
I
S
A
L
E
G
A
E
S
T
L
L
M
A
S
G
M
C
A
S
T
V
-
M
L
-
L
-
A
L
-
V
-
P
A
G
G
H
I
V
T
T
T
D
C
Y
R
K
T
R
I
F
I
-
E
T
-
I
L
P
--
K
--
M
--
G
---
I
T
A
T
V
--
I
D
P
A
--
D
V
G
A
L
----
E
L
ALN
Q
-
K
K
V
N
L
F
F
T
E
S
P
T
N
P
F
L
R
C
V
D
I
E
L
V
S
K
L
C
H
E
--
K
------
G
A
L
V
C
I
D
G
T
F
A
T
P
L
N
Q
K
A
L
A
L
G
A
D
L
V
L
H
S
A
T
K
F
L
G
G
H
N
D
V
L
A
G
--
C
I
S
--
G
P
L
K
L
V
S
-
E
I
R
N
--
L
--
H
-
H
I
L
G
G
A
L
N
P
N
A
A
Y
L
I
I
R
G
M
K
T
L
H
L
R
V
Q
Q
Q
N
S
T
A
L
R
M
A
E
I
L
E
A
H
P
K
V
R
H
V
Y
Y
PGLQSHPEHHIAKKQM
T
------------------
G
----------------
F
----------------
G
G
A
V
S
F
E
V
D--
G
---
D
L
-
L
T
-
T
A
-
K
F
V
D
A
L
K
I
P
Y
I
A
P
S
F
G
G
C
E
S
I
V
D
Q
P
A
I
M
S
Y
W
D
L
S
Q
S
D
R
A
K
Y
G
I
M
D
N
L
V
R
F
S
F
G
V
E
D
F
D
D
L
K
A
D
I
L
Q
A
L
D
-
128
PsiBlast_CBE
84.78
34%
0
- C- -
-
1I48
2
?
E:
[71-443]
--------------
G
I
V
T
D
A
I
T
T
P
V
V
NT
S
A
Y
F
F
N
K
T
S
--
E
L
I
D
F
--------
K
EK
R
--------------
R
------
A
S
F
E
Y
G
R
Y
G
N
P
T
T
V
V
L
E
E
K
I
S
A
L
E
G
A
E
S
T
L
L
M
A
S
G
M
C
A
S
T
V
-
M
L
-
L
-
A
L
-
V
-
P
A
G
G
H
I
V
T
T
T
D
C
Y
R
K
T
R
I
F
I
-
E
T
-
I
L
P
--
K
--
M
--
G
---
I
T
A
T
V
--
I
D
P
A
--
D
V
G
A
L
----
E
L
ALN
Q
-
K
K
V
N
L
F
F
T
E
S
P
T
N
P
F
L
R
C
V
D
I
E
L
V
S
K
L
C
H
E
--
K
------
G
A
L
V
C
I
D
G
T
F
A
T
P
L
N
Q
K
A
L
A
L
G
A
D
L
V
L
H
S
A
T
K
F
L
G
G
H
N
D
V
L
A
G
--
C
I
S
--
G
P
L
K
L
V
S
-
E
I
R
N
--
L
--
H
-
H
I
L
G
G
A
L
N
P
N
A
A
Y
L
I
I
R
G
M
K
T
L
H
L
R
V
Q
Q
Q
N
S
T
A
L
R
M
A
E
I
L
E
A
H
P
K
V
R
H
V
Y
Y
PGLQSHPEHHIAKKQM
T
------------------
G
----------------
F
----------------
G
G
A
V
S
F
E
V
D--
G
---
D
L
-
L
T
-
T
A
-
K
F
V
D
A
L
K
I
P
Y
I
A
P
S
F
G
G
C
E
S
I
V
D
Q
P
A
I
M
S
Y
W
D
L
S
Q
S
D
R
A
K
Y
G
I
M
D
N
L
V
R
F
S
F
G
V
E
D
F
D
D
L
K
A
D
I
L
Q
A
L
D
-
127
PsiBlast_CBE
84.78
34%
0
- C- -
-
1I48
2
?
F:
[71-443]
--------------
G
I
V
T
D
A
I
T
T
P
V
V
NT
S
A
Y
F
F
N
K
T
S
--
E
L
I
D
F
--------
K
EK
R
--------------
R
------
A
S
F
E
Y
G
R
Y
G
N
P
T
T
V
V
L
E
E
K
I
S
A
L
E
G
A
E
S
T
L
L
M
A
S
G
M
C
A
S
T
V
-
M
L
-
L
-
A
L
-
V
-
P
A
G
G
H
I
V
T
T
T
D
C
Y
R
K
T
R
I
F
I
-
E
T
-
I
L
P
--
K
--
M
--
G
---
I
T
A
T
V
--
I
D
P
A
--
D
V
G
A
L
----
E
L
ALN
Q
-
K
K
V
N
L
F
F
T
E
S
P
T
N
P
F
L
R
C
V
D
I
E
L
V
S
K
L
C
H
E
--
K
------
G
A
L
V
C
I
D
G
T
F
A
T
P
L
N
Q
K
A
L
A
L
G
A
D
L
V
L
H
S
A
T
K
F
L
G
G
H
N
D
V
L
A
G
--
C
I
S
--
G
P
L
K
L
V
S
-
E
I
R
N
--
L
--
H
-
H
I
L
G
G
A
L
N
P
N
A
A
Y
L
I
I
R
G
M
K
T
L
H
L
R
V
Q
Q
Q
N
S
T
A
L
R
M
A
E
I
L
E
A
H
P
K
V
R
H
V
Y
Y
PGLQSHPEHHIAKKQM
T
------------------
G
----------------
F
----------------
G
G
A
V
S
F
E
V
D--
G
---
D
L
-
L
T
-
T
A
-
K
F
V
D
A
L
K
I
P
Y
I
A
P
S
F
G
G
C
E
S
I
V
D
Q
P
A
I
M
S
Y
W
D
L
S
Q
S
D
R
A
K
Y
G
I
M
D
N
L
V
R
F
S
F
G
V
E
D
F
D
D
L
K
A
D
I
L
Q
A
L
D
-
126
PsiBlast_CBE
84.78
34%
0
- C- -
-
1I48
2
?
G:
[71-443]
--------------
G
I
V
T
D
A
I
T
T
P
V
V
NT
S
A
Y
F
F
N
K
T
S
--
E
L
I
D
F
--------
K
EK
R
--------------
R
------
A
S
F
E
Y
G
R
Y
G
N
P
T
T
V
V
L
E
E
K
I
S
A
L
E
G
A
E
S
T
L
L
M
A
S
G
M
C
A
S
T
V
-
M
L
-
L
-
A
L
-
V
-
P
A
G
G
H
I
V
T
T
T
D
C
Y
R
K
T
R
I
F
I
-
E
T
-
I
L
P
--
K
--
M
--
G
---
I
T
A
T
V
--
I
D
P
A
--
D
V
G
A
L
----
E
L
ALN
Q
-
K
K
V
N
L
F
F
T
E
S
P
T
N
P
F
L
R
C
V
D
I
E
L
V
S
K
L
C
H
E
--
K
------
G
A
L
V
C
I
D
G
T
F
A
T
P
L
N
Q
K
A
L
A
L
G
A
D
L
V
L
H
S
A
T
K
F
L
G
G
H
N
D
V
L
A
G
--
C
I
S
--
G
P
L
K
L
V
S
-
E
I
R
N
--
L
--
H
-
H
I
L
G
G
A
L
N
P
N
A
A
Y
L
I
I
R
G
M
K
T
L
H
L
R
V
Q
Q
Q
N
S
T
A
L
R
M
A
E
I
L
E
A
H
P
K
V
R
H
V
Y
Y
PGLQSHPEHHIAKKQM
T
------------------
G
----------------
F
----------------
G
G
A
V
S
F
E
V
D--
G
---
D
L
-
L
T
-
T
A
-
K
F
V
D
A
L
K
I
P
Y
I
A
P
S
F
G
G
C
E
S
I
V
D
Q
P
A
I
M
S
Y
W
D
L
S
Q
S
D
R
A
K
Y
G
I
M
D
N
L
V
R
F
S
F
G
V
E
D
F
D
D
L
K
A
D
I
L
Q
A
L
D
-
125
PsiBlast_CBE
84.78
34%
0
- C- -
-
1I48
2
?
H:
[71-443]
--------------
G
I
V
T
D
A
I
T
T
P
V
V
NT
S
A
Y
F
F
N
K
T
S
--
E
L
I
D
F
--------
K
EK
R
--------------
R
------
A
S
F
E
Y
G
R
Y
G
N
P
T
T
V
V
L
E
E
K
I
S
A
L
E
G
A
E
S
T
L
L
M
A
S
G
M
C
A
S
T
V
-
M
L
-
L
-
A
L
-
V
-
P
A
G
G
H
I
V
T
T
T
D
C
Y
R
K
T
R
I
F
I
-
E
T
-
I
L
P
--
K
--
M
--
G
---
I
T
A
T
V
--
I
D
P
A
--
D
V
G
A
L
----
E
L
ALN
Q
-
K
K
V
N
L
F
F
T
E
S
P
T
N
P
F
L
R
C
V
D
I
E
L
V
S
K
L
C
H
E
--
K
------
G
A
L
V
C
I
D
G
T
F
A
T
P
L
N
Q
K
A
L
A
L
G
A
D
L
V
L
H
S
A
T
K
F
L
G
G
H
N
D
V
L
A
G
--
C
I
S
--
G
P
L
K
L
V
S
-
E
I
R
N
--
L
--
H
-
H
I
L
G
G
A
L
N
P
N
A
A
Y
L
I
I
R
G
M
K
T
L
H
L
R
V
Q
Q
Q
N
S
T
A
L
R
M
A
E
I
L
E
A
H
P
K
V
R
H
V
Y
Y
PGLQSHPEHHIAKKQM
T
------------------
G
----------------
F
----------------
G
G
A
V
S
F
E
V
D--
G
---
D
L
-
L
T
-
T
A
-
K
F
V
D
A
L
K
I
P
Y
I
A
P
S
F
G
G
C
E
S
I
V
D
Q
P
A
I
M
S
Y
W
D
L
S
Q
S
D
R
A
K
Y
G
I
M
D
N
L
V
R
F
S
F
G
V
E
D
F
D
D
L
K
A
D
I
L
Q
A
L
D
-
124
PsiBlast_CBE
84.78
34%
0
- C- -
-
1I48
2
?
I:
[71-443]
--------------
G
I
V
T
D
A
I
T
T
P
V
V
NT
S
A
Y
F
F
N
K
T
S
--
E
L
I
D
F
--------
K
EK
R
--------------
R
------
A
S
F
E
Y
G
R
Y
G
N
P
T
T
V
V
L
E
E
K
I
S
A
L
E
G
A
E
S
T
L
L
M
A
S
G
M
C
A
S
T
V
-
M
L
-
L
-
A
L
-
V
-
P
A
G
G
H
I
V
T
T
T
D
C
Y
R
K
T
R
I
F
I
-
E
T
-
I
L
P
--
K
--
M
--
G
---
I
T
A
T
V
--
I
D
P
A
--
D
V
G
A
L
----
E
L
ALN
Q
-
K
K
V
N
L
F
F
T
E
S
P
T
N
P
F
L
R
C
V
D
I
E
L
V
S
K
L
C
H
E
--
K
------
G
A
L
V
C
I
D
G
T
F
A
T
P
L
N
Q
K
A
L
A
L
G
A
D
L
V
L
H
S
A
T
K
F
L
G
G
H
N
D
V
L
A
G
--
C
I
S
--
G
P
L
K
L
V
S
-
E
I
R
N
--
L
--
H
-
H
I
L
G
G
A
L
N
P
N
A
A
Y
L
I
I
R
G
M
K
T
L
H
L
R
V
Q
Q
Q
N
S
T
A
L
R
M
A
E
I
L
E
A
H
P
K
V
R
H
V
Y
Y
PGLQSHPEHHIAKKQM
T
------------------
G
----------------
F
----------------
G
G
A
V
S
F
E
V
D--
G
---
D
L
-
L
T
-
T
A
-
K
F
V
D
A
L
K
I
P
Y
I
A
P
S
F
G
G
C
E
S
I
V
D
Q
P
A
I
M
S
Y
W
D
L
S
Q
S
D
R
A
K
Y
G
I
M
D
N
L
V
R
F
S
F
G
V
E
D
F
D
D
L
K
A
D
I
L
Q
A
L
D
-
123
PsiBlast_CBE
84.78
34%
0
- C- -
-
1I48
2
?
J:
[71-443]
--------------
G
I
V
T
D
A
I
T
T
P
V
V
NT
S
A
Y
F
F
N
K
T
S
--
E
L
I
D
F
--------
K
EK
R
--------------
R
------
A
S
F
E
Y
G
R
Y
G
N
P
T
T
V
V
L
E
E
K
I
S
A
L
E
G
A
E
S
T
L
L
M
A
S
G
M
C
A
S
T
V
-
M
L
-
L
-
A
L
-
V
-
P
A
G
G
H
I
V
T
T
T
D
C
Y
R
K
T
R
I
F
I
-
E
T
-
I
L
P
--
K
--
M
--
G
---
I
T
A
T
V
--
I
D
P
A
--
D
V
G
A
L
----
E
L
ALN
Q
-
K
K
V
N
L
F
F
T
E
S
P
T
N
P
F
L
R
C
V
D
I
E
L
V
S
K
L
C
H
E
--
K
------
G
A
L
V
C
I
D
G
T
F
A
T
P
L
N
Q
K
A
L
A
L
G
A
D
L
V
L
H
S
A
T
K
F
L
G
G
H
N
D
V
L
A
G
--
C
I
S
--
G
P
L
K
L
V
S
-
E
I
R
N
--
L
--
H
-
H
I
L
G
G
A
L
N
P
N
A
A
Y
L
I
I
R
G
M
K
T
L
H
L
R
V
Q
Q
Q
N
S
T
A
L
R
M
A
E
I
L
E
A
H
P
K
V
R
H
V
Y
Y
PGLQSHPEHHIAKKQM
T
------------------
G
----------------
F
----------------
G
G
A
V
S
F
E
V
D--
G
---
D
L
-
L
T
-
T
A
-
K
F
V
D
A
L
K
I
P
Y
I
A
P
S
F
G
G
C
E
S
I
V
D
Q
P
A
I
M
S
Y
W
D
L
S
Q
S
D
R
A
K
Y
G
I
M
D
N
L
V
R
F
S
F
G
V
E
D
F
D
D
L
K
A
D
I
L
Q
A
L
D
-
122
PsiBlast_CBE
84.78
34%
0
- C- -
-
1I48
2
?
K:
[71-443]
--------------
G
I
V
T
D
A
I
T
T
P
V
V
NT
S
A
Y
F
F
N
K
T
S
--
E
L
I
D
F
--------
K
EK
R
--------------
R
------
A
S
F
E
Y
G
R
Y
G
N
P
T
T
V
V
L
E
E
K
I
S
A
L
E
G
A
E
S
T
L
L
M
A
S
G
M
C
A
S
T
V
-
M
L
-
L
-
A
L
-
V
-
P
A
G
G
H
I
V
T
T
T
D
C
Y
R
K
T
R
I
F
I
-
E
T
-
I
L
P
--
K
--
M
--
G
---
I
T
A
T
V
--
I
D
P
A
--
D
V
G
A
L
----
E
L
ALN
Q
-
K
K
V
N
L
F
F
T
E
S
P
T
N
P
F
L
R
C
V
D
I
E
L
V
S
K
L
C
H
E
--
K
------
G
A
L
V
C
I
D
G
T
F
A
T
P
L
N
Q
K
A
L
A
L
G
A
D
L
V
L
H
S
A
T
K
F
L
G
G
H
N
D
V
L
A
G
--
C
I
S
--
G
P
L
K
L
V
S
-
E
I
R
N
--
L
--
H
-
H
I
L
G
G
A
L
N
P
N
A
A
Y
L
I
I
R
G
M
K
T
L
H
L
R
V
Q
Q
Q
N
S
T
A
L
R
M
A
E
I
L
E
A
H
P
K
V
R
H
V
Y
Y
PGLQSHPEHHIAKKQM
T
------------------
G
----------------
F
----------------
G
G
A
V
S
F
E
V
D--
G
---
D
L
-
L
T
-
T
A
-
K
F
V
D
A
L
K
I
P
Y
I
A
P
S
F
G
G
C
E
S
I
V
D
Q
P
A
I
M
S
Y
W
D
L
S
Q
S
D
R
A
K
Y
G
I
M
D
N
L
V
R
F
S
F
G
V
E
D
F
D
D
L
K
A
D
I
L
Q
A
L
D
-
121
PsiBlast_CBE
84.78
34%
0
- C- -
-
1I48
12
?
L:
[71-443]
--------------
G
I
V
T
D
A
I
T
T
P
V
V
NT
S
A
Y
F
F
N
K
T
S
--
E
L
I
D
F
--------
K
EK
R
--------------
R
------
A
S
F
E
Y
G
R
Y
G
N
P
T
T
V
V
L
E
E
K
I
S
A
L
E
G
A
E
S
T
L
L
M
A
S
G
M
C
A
S
T
V
-
M
L
-
L
-
A
L
-
V
-
P
A
G
G
H
I
V
T
T
T
D
C
Y
R
K
T
R
I
F
I
-
E
T
-
I
L
P
--
K
--
M
--
G
---
I
T
A
T
V
--
I
D
P
A
--
D
V
G
A
L
----
E
L
ALN
Q
-
K
K
V
N
L
F
F
T
E
S
P
T
N
P
F
L
R
C
V
D
I
E
L
V
S
K
L
C
H
E
--
K
------
G
A
L
V
C
I
D
G
T
F
A
T
P
L
N
Q
K
A
L
A
L
G
A
D
L
V
L
H
S
A
T
K
F
L
G
G
H
N
D
V
L
A
G
--
C
I
S
--
G
P
L
K
L
V
S
-
E
I
R
N
--
L
--
H
-
H
I
L
G
G
A
L
N
P
N
A
A
Y
L
I
I
R
G
M
K
T
L
H
L
R
V
Q
Q
Q
N
S
T
A
L
R
M
A
E
I
L
E
A
H
P
K
V
R
H
V
Y
Y
PGLQSHPEHHIAKKQM
T
------------------
G
----------------
F
----------------
G
G
A
V
S
F
E
V
D--
G
---
D
L
-
L
T
-
T
A
-
K
F
V
D
A
L
K
I
P
Y
I
A
P
S
F
G
G
C
E
S
I
V
D
Q
P
A
I
M
S
Y
W
D
L
S
Q
S
D
R
A
K
Y
G
I
M
D
N
L
V
R
F
S
F
G
V
E
D
F
D
D
L
K
A
D
I
L
Q
A
L
D
-
49
PsiBlast_CBE
80.66
36%
-12
- C1 -
-
3JWA
6
?
A:
[10-393]
-------
N
T
Q
I
V
H
A
G
Q
Q
P
D
P
S
T
G
A
L
S
--
T
P
I
F
Q
T
S
T
F
V
F
D
S
A
E
Q
--------
G
--
A
--------------
A
R
F
A
LE
E
S
G
Y
I
Y
T
R
L
G
N
P
T
T
D
A
L
E
K
K
L
A
V
L
E
R
G
E
A
G
L
A
T
A
S
G
I
S
A
-
I
T
-
T
T
-
L
L
T
L
-
C
-
Q
Q
G
D
H
I
V
S
A
S
A
I
Y
G
C
T
H
A
F
L
-
S
H
-
S
M
P
--
K
--
F
--
G
---
I
N
V
S
F
V
D
A
A
K
P
--
E
E
I
R
A
----
A
M
---
R
-
P
E
T
K
V
V
Y
I
E
T
P
A
N
P
T
L
S
L
V
D
I
E
T
V
A
G
I
A
H
Q
--
Q
------
G
A
L
L
V
V
D
N
T
F
M
S
P
Y
C
Q
Q
P
L
Q
L
G
A
D
I
V
V
H
S
V
T
K
Y
I
N
G
H
G
D
V
I
G
G
I
-
I
V
G
--
K
Q
E
F
I
D
Q
-
A
R
F
V
--
G
--
L
K
D
I
T
G
G
C
M
S
P
F
N
A
W
L
T
L
R
G
V
K
T
L
G
I
R
M
E
R
H
C
E
N
A
L
K
I
A
R
F
L
E
G
H
P
S
I
T
R
V
Y
Y
----------------
P
------------------
G
LSSHP
Q
Y
E
L
G
Q
R
Q
MSL
P
----------------
G
G
I
I
S
F
E
I
---
A
---
G
G
-
L
E
-
A
G
R
R
M
I
N
S
V
E
L
C
L
L
A
V
S
L
G
D
T
E
T
L
I
Q
H
P
A
S
M
T
H
S
P
V
A
P
E
E
R
L
K
A
G
I
T
D
G
L
I
R
L
S
V
G
L
E
D
P
E
D
I
I
N
D
L
E
H
A
I
--
19
PsiBlast_PDB
80.61
36%
-13
- C1 -
-
3MKJ
1
?
A:
[10-393]
-------
N
T
Q
I
V
H
A
G
Q
Q
P
D
P
S
T
G
A
L
S
--
T
P
I
F
Q
T
S
T
F
V
F
D
S
A
E
Q
--------
G
--
A
--------------
A
R
F-----------
L
G
N
P
T
T
D
A
L
E
K
K
L
A
V
L
E
R
G
E
A
G
L
A
T
A
S
G
I
S
A
-
I
T
-
T
T
-
L
L
T
L
-
C
-
Q
Q
G
D
H
I
V
S
A
S
A
I
Y
G
C
T
H
A
F
L
-
S
H
-
S
M
P
--
K
--
F
--
G
---
I
N
V
S
F
VD
A
A
K
P
--
E
E
I
R
A
----
A
M
---
R
-
P
E
T
K
V
V
Y
I
E
T
P
A
N
P
T
L
S
L
V
D
I
E
T
V
A
G
I
A
H
Q
--
Q
------
G
A
L
L
V
V
D
N
T
F
M
S
P
Y
C
Q
Q
P
L
Q
L
G
A
D
I
V
V
H
S
V
T
K
Y
I
N
G
H
G
D
V
I
G
G
I
-
I
V
G
--
K
Q
E
F
I
D
Q
-
A
R
F
V
--
G
--
L
K
D
I
T
G
G
C
M
S
P
F
N
A
W
L
T
L
R
G
V
K
T
L
G
I
R
M
E
R
H
C
E
N
A
L
K
I
A
R
F
L
E
G
H
P
S
I
T
R
V
Y
Y
----------------
P
------------------
G
LSS
H
P
Q
Y
E
L
G
Q
RQMSL
P
----------------
G
G
I
I
S
F
E
I
---
A
---
G
G
-
L
E
-
A
G
R
R
M
I
N
S
V
E
L
C
L
L
A
V
S
L
G
D
T
E
T
L
I
Q
H
P
A
S
M
T
H
S
P
V
A
P
E
E
R
L
K
A
G
I
T
D
G
L
I
R
L
S
V
G
L
E
D
P
E
D
I
I
N
D
L
E
H
A
I
--
154
HHSearch
80.19
36%
-10
- C1 -
-
1E5E
3
?
A:
[4-394]
--
E
R
M
T
P
A
T
A
C
I
H
A
N
P
Q
-
K
D
Q
F
G
A
A
I
--
P
P
I
Y
Q
T
S
T
F
--
V
F
D
N
C
--------
Q
--
Q
G
G
N
R
F
A
GQ------
E
------
S
G
Y
I
Y
T
R
L
G
N
P
T
V
S
N
L
E
G
K
I
A
F
L
E
K
T
E
A
C
V
A
T
S
S
G
M
G
A
-
I
A
-
A
T
-
V
L
T
I
-
L
-
K
A
G
D
H
L
I
S
D
E
C
L
Y
G
C
T
H
A
L
F
-
E
H
-
A
L
T
--
K
F
G
I
--
Q
---
V
D
F
I
N
--
T
A
I
P
--
G
E
V
K
K
----
H
M
---
K
-
P
N
T
K
I
V
Y
F
E
T
P
A
N
P
T
L
K
I
I
D
M
E
R
V
C
K
D
A
H
S
Q-
E
------
G
V
L
V
I
A
D
N
T
F
C
S
P
M
I
T
N
P
V
D
F
G
V
D
V
V
V
H
S
A
T
K
Y
I
N
G
H
T
D
V
V
A
G
L
-
I
C
G
--
K
-
A
D
L
L
Q
-
Q
I
R
M
VG
I
--
K
-
D
I
T
G
S
V
I
S
P
H
D
A
W
L
I
T
R
G
L
S
T
L
N
I
R
M
K
A
E
S
E
N
A
M
K
V
A
E
Y
L
K
S
H
P
A
V
E
K
V
Y
Y
----------------
P
------------------
G
FEDHEG
H
D
I
A
K
K
Q
M
RM
Y
----------------
G
S
M
I
T
F
I
L
---
K
---
S
G
F
E
G
-
A
K
-
K
L
L
D
N
L
K
L
I
T
L
A
V
S
L
G
G
C
E
S
L
I
Q
H
P
A
S
M
T
H
A
V
V
P
K
E
E
R
E
A
A
G
I
T
D
G
M
I
R
L
S
V
G
I
E
D
A
D
E
L
I
A
D
F
K
Q
G
L
D
A
47
PsiBlast_CBE
79.30
36%
-10
- C1 -
-
3JW9
2
?
A:
[10-393]
-------
N
T
Q
I
V
H
A
G
Q
Q
P
D
P
S
T
G
A
L
S
--
T
P
I
F
Q
T
S
T
F
V
F
D
S
A
E
Q
--------
G
--
A
--------------
A
R
F
A
LE
E
S
G
Y
I
Y
T
R
L
G
N
P
T
T
D
A
L
E
K
K
L
A
V
L
E
R
G
E
A
G
L
A
T
A
S
G
I
S
A
-
I
T
-
T
T
-
L
L
T
L
-
C
-
Q
Q
G
D
H
I
V
S
A
S
A
I
Y
G
C
T
H
A
F
L
-
S
H
-
S
M
P
--
K
--
F
--
G
---
I
N
V
S
F
V
D
A
A
K
P
--
E
E
I
R
A
----
A
M
---
R
-
P
E
T
K
V
V
Y
I
E
T
P
A
N
P
T
L
S
L
V
D
I
E
T
V
A
G
I
A
H
Q
--
Q
------
G
A
L
L
V
V
D
N
T
F
M
S
P
Y
C
Q
Q
P
L
Q
L
G
A
D
I
V
V
H
S
V
T
K
Y
I
N
G
H
G
D
V
I
G
G
I
-
I
V
G
--
K
Q
E
F
I
D
Q
-
A
R
F
V
--
G
--
L
K
D
I
T
G
G
C
M
S
P
F
N
A
W
L
T
L
R
G
V
K
T
L
G
I
R
M
E
R
H
C
E
N
A
L
K
I
A
R
F
L
E
G
H
P
S
I
T
R
V
Y
Y
----------------
P
------------------
G
LSSHP
Q
Y
E
L
G
Q
R
Q
MSL
P
----------------
G
G
I
I
S
F
E
I
---
A
---
G
G
-
L
E
-
A
G
R
R
M
I
N
S
V
E
L
C
L
L
A
V
S
L
G
D
T
E
T
L
I
Q
H
P
A
S
M
T
H
S
P
V
A
P
E
E
R
L
K
A
G
I
T
D
G
L
I
R
L
S
V
G
L
E
D
P
E
D
I
I
N
D
L
E
H
A
I
--
13
PsiBlast_PDB
78.76
36%
-11
- C1 -
-
4OMA
5
?
A:
[10-393]
-------
N
T
Q
I
V
H
A
G
Q
Q
P
D
P
S
T
G
A
L
S
--
T
P
I
F
Q
T
S
T
F
V
F
D
S
A
E
Q
--------
G
--
A
--------------
A
R
F
A
LE
E
S
G
Y
I
Y
T
R
L
G
N
P
T
T
D
A
L
E
K
K
L
A
V
L
E
R
G
E
A
G
L
A
T
A
S
G
I
S
A
-
I
T
-
T
T
-
L
L
T
L
-
C
-
Q
Q
G
D
H
I
V
S
A
S
A
I
Y
G
C
T
H
A
F
L
-
S
H
-
S
M
P
--
K
--
F
--
G
---
I
N
V
S
F
V
D
A
A
K
P
--
E
E
I
R
A
----
A
M
---
R
-
P
E
T
K
V
V
Y
I
E
T
P
A
N
P
T
L
S
L
V
D
I
E
T
V
A
G
I
A
H
Q
--
Q
------
G
A
L
L
V
V
D
N
T
F
M
S
P
Y
C
Q
Q
P
L
Q
L
G
A
D
I
V
V
H
S
V
T
K
Y
I
N
G
H
G
D
V
I
G
G
I
-
I
V
G
--
K
Q
E
F
I
D
Q
-
A
R
F
V
--
G
--
L
K
D
I
T
G
G
C
M
S
P
F
N
A
W
L
T
L
R
G
V
K
T
L
G
I
R
M
E
R
H
C
E
N
A
L
K
I
A
R
F
L
E
G
H
P
S
I
T
R
V
Y
Y
----------------
P
------------------
G
LSSHPQ
Y
E
L
G
Q
R
Q
M
SL
P
----------------
G
G
I
I
S
F
E
I
---
A
---
G
G
-
L
E
-
A
G
R
R
M
I
N
S
V
E
L
C
L
L
A
V
S
L
G
D
T
E
T
L
I
Q
H
P
A
S
M
T
H
S
P
V
A
P
E
E
R
L
K
A
G
I
T
D
G
L
I
R
L
S
V
G
L
E
D
P
E
D
I
I
N
D
L
E
H
A
I
--
15
PsiBlast_PDB
78.38
37%
-10
- C1 -
-
4HF8
5
?
A:
[10-393]
-------
N
T
Q
I
V
H
A
G
Q
Q
P
D
P
S
T
G
A
L
S
--
T
P
I
F
Q
T
S
T
F
V
F
D
S
A
E
Q
--------
G
--
A
--------------
A
R
F
A
LE
E
S
G
Y
I
Y
T
R
L
G
N
P
T
T
D
A
L
E
K
K
L
A
V
L
E
R
G
E
A
G
L
A
T
A
S
G
I
S
A
-
I
T
-
T
T
-
L
L
T
L
-
C
-
Q
Q
G
D
H
I
V
S
A
S
A
I
Y
G
C
T
H
A
F
L
-
S
H
S
M
P
K
--
F
--
G
I
-
N
---
V
R
F
V
D
--
A
A
K
P
--
E
E
I
R
A
----
A
M
---
R
-
P
E
T
K
V
V
Y
I
E
T
P
A
N
P
T
L
S
L
V
D
I
E
T
V
A
G
I
A
H
Q
--
Q
------
G
A
L
L
V
V
D
N
T
F
M
S
P
Y
C
Q
Q
P
L
Q
L
G
A
D
I
V
V
H
S
V
T
K
Y
I
N
G
H
G
D
V
I
G
G
I
-
I
V
G
--
K
Q
E
F
I
D
Q
-
A
R
F
V
--
G
--
L
K
D
I
T
G
G
C
M
S
P
F
N
A
W
L
T
L
R
G
V
K
T
L
G
I
R
M
E
R
H
C
E
N
A
L
K
I
A
R
F
L
E
G
H
P
S
I
T
R
V
Y
Y
----------------
P
------------------
G
LSSHPQ
Y
E
L
G
Q
R
QMSL
P
----------------
G
G
I
I
S
F
E
I
---
A
---
G
G
-
L
E
-
A
G
R
R
M
I
N
S
V
E
L
C
L
L
A
V
S
L
G
D
T
E
T
L
I
Q
H
P
A
S
M
T
H
S
P
V
A
P
E
E
R
L
K
A
G
I
T
D
G
L
I
R
L
S
V
G
L
E
D
P
E
D
I
I
N
D
L
E
H
A
I
--
78
PsiBlast_CBE
77.83
35%
-9
- C1 -
-
1E5F
3
?
A:
[23-393]
----------------------
G
A
A
I
--
P
P
I
Y
Q
T
S
T
F
--
V
F
D
N
C
Q
Q
G
G
N
R
F
A
G
--
Q
--------------
E
------
S
G
Y
I
Y
T
R
L
G
N
P
T
V
S
N
L
E
G
K
I
A
F
L
E
K
T
E
A
C
V
A
T
S
S
G
M
G
A
-
I
A
A
T
V
-
L
-
T
I
-
L
-
K
A
G
D
H
L
I
S
D
E
C
L
Y
G
C
T
H
A
L
F
-
E
H
-
A
L
T
--
K
--
F
--
G
---
I
Q
V
D
F
--
I
N
T
A
IP
G
E
V
K
K
----
H
M
---
K
-
P
N
T
K
I
V
Y
F
E
T
P
A
N
P
T
L
K
I
I
D
M
E
R
V
C
K
D
A
H
S
--
Q
E-----
G
V
L
V
I
A
D
N
T
F
C
S
P
M
I
T
N
P
V
D
F
G
V
D
V
V
V
H
S
A
T
K
Y
I
N
G
H
T
D
V
V
A
G
L
-
I
C
G
--
K
A
D
L
L
Q
Q
-
I
R
M
V
--
G
--
I
K
D
I
T
G
S
V
I
S
P
H
D
A
W
L
I
T
R
G
L
S
T
L
N
I
R
M
K
A
E
S
E
N
A
M
K
V
A
E
Y
L
K
S
H
P
A
V
E
K
V
Y
Y
----------------
P
------------------
G
FEDHEG
H
D
I
A
K
K
Q
M
RM
Y
----------------
G
S
M
I
T
F
I
L
---
K
---
S
G
-
F
E
G
A
K
-
K
L
L
D
N
L
K
L
I
T
L
A
V
S
L
G
G
C
E
S
L
I
Q
H
P
A
S
M
T
H
A
V
V
P
K
E
E
R
E
A
A
G
I
T
D
G
M
I
R
L
S
V
G
I
E
D
A
D
E
L
I
A
D
F
K
Q
G
L
D
-
48
PsiBlast_CBE
77.56
36%
-8
- C1 -
-
3JWB
4
?
A:
[10-393]
-------
N
T
Q
I
V
H
A
G
Q
Q
P
D
P
S
T
G
A
L
S
--
T
P
I
F
Q
T
S
T
F
V
F
D
S
A
E
Q
--------
G
--
A
--------------
A
R
F
A
LE
E
S
G
Y
I
Y
T
R
L
G
N
P
T
T
D
A
L
E
K
K
L
A
V
L
E
R
G
E
A
G
L
A
T
A
S
G
I
S
A
-
I
T
-
T
T
-
L
L
T
L
-
C
-
Q
Q
G
D
H
I
V
S
A
S
A
I
Y
G
C
T
H
A
F
L
-
S
H
-
S
M
P
--
K
--
F
--
G
---
I
N
V
S
F
V
D
A
A
K
P
--
E
E
I
R
A
----
A
M
---
R
-
P
E
T
K
V
V
Y
I
E
T
P
A
N
P
T
L
S
L
V
D
I
E
T
V
A
G
I
A
H
Q
--
Q
------
G
A
L
L
V
V
D
N
T
F
M
S
P
Y
C
Q
Q
P
L
Q
L
G
A
D
I
V
V
H
S
V
T
K
Y
I
N
G
H
G
D
V
I
G
G
I
-
I
V
G
--
K
Q
E
F
I
D
Q
-
A
R
F
V
--
G
--
L
K
D
I
T
G
G
C
M
S
P
F
N
A
W
L
T
L
R
G
V
K
T
L
G
I
R
M
E
R
H
C
E
N
A
L
K
I
A
R
F
L
E
G
H
P
S
I
T
R
V
Y
Y
----------------
P
------------------
G
LSSHP
Q
Y
E
L
G
Q
R
Q
MSL
P
----------------
G
G
I
I
S
F
E
I
---
A
---
G
G
-
L
E
-
A
G
R
R
M
I
N
S
V
E
L
C
L
L
A
V
S
L
G
D
T
E
T
L
I
Q
H
P
A
S
M
T
H
S
P
V
A
P
E
E
R
L
K
A
G
I
T
D
G
L
I
R
L
S
V
G
L
E
D
P
E
D
I
I
N
D
L
E
H
A
I
--
77
PsiBlast_CBE
77.51
35%
-10
- C1 -
-
1E5F
2
?
B:
[23-393]
----------------------
G
A
A
I
--
P
P
I
Y
Q
T
S
T
F
--
V
F
D
N
C
QQGGNRFA
G
--
Q
--------------
E
------
S
G
Y
I
Y
T
R
L
G
N
P
T
V
S
N
L
E
G
K
I
A
F
L
E
K
T
E
A
C
V
A
T
S
S
G
M
G
A
-
I
A
A
T
V
-
L
-
T
I
-
L
-
K
A
G
D
H
L
I
S
D
E
C
L
Y
G
C
T
H
A
L
F
-
E
H
-
A
L
T
--
K
--
F
--
G
---
I
Q
V
D
F
--
I
N
T
A
IP
G
E
V
K
K
----
H
M
---
K
-
P
N
T
K
I
V
Y
F
E
T
P
A
N
P
T
L
K
I
I
D
M
E
R
V
C
K
D
A
H
S
--
Q
E-----
G
V
L
V
I
A
D
N
T
F
C
S
P
M
I
T
N
P
V
D
F
G
V
D
V
V
V
H
S
A
T
K
Y
I
N
G
H
T
D
V
V
A
G
L
-
I
C
G
--
K
A
D
L
L
Q
Q
-
I
R
M
V
--
G
--
I
K
D
I
T
G
S
V
I
S
P
H
D
A
W
L
I
T
R
G
L
S
T
L
N
I
R
M
K
A
E
S
E
N
A
M
K
V
A
E
Y
L
K
S
H
P
A
V
E
K
V
Y
Y
----------------
P
------------------
G
FEDHEGHDIAKKQMRM
Y
----------------
G
S
M
I
T
F
I
L
---
K
---
S
G
-
F
E
G
A
K
-
K
L
L
D
N
L
K
L
I
T
L
A
V
S
L
G
G
C
E
S
L
I
Q
H
P
A
S
M
T
H
A
V
V
P
K
E
E
R
E
A
A
G
I
T
D
G
M
I
R
L
S
V
G
I
E
D
A
D
E
L
I
A
D
F
K
Q
G
L
D
-
16
PsiBlast_PDB
77.27
36%
-7
- C1 -
-
5M3Z
2
?
A:
[10-393]
-------
N
T
Q
I
V
H
A
G
Q
Q
P
D
P
S
T
G
A
L
S
--
T
P
I
F
Q
T
S
T
F
V
F
D
S
A
E
Q
--------
G
--
A
--------------
A
R
F
A
LE
E
S
G
Y
I
Y
T
R
L
G
N
P
T
T
D
A
L
E
K
K
L
A
V
L
E
R
G
E
A
G
L
A
T
A
S
G
I
S
A
-
I
T
-
T
T
-
L
L
T
L
-
C
-
Q
Q
G
D
H
I
V
S
A
S
A
I
Y
G
H
T
H
A
F
L
-
S
H
-
S
M
P
--
K
--
F
--
G
---
I
N
V
S
F
V
D
A
A
K
P
--
E
E
I
R
A
----
A
M
---
R
-
P
E
T
K
V
V
Y
I
E
T
P
A
N
P
T
L
S
L
V
D
I
E
T
V
A
G
I
A
H
Q
--
Q
------
G
A
L
L
V
V
D
N
T
F
M
S
P
Y
C
Q
Q
P
L
Q
L
G
A
D
I
V
V
H
S
V
T
K
Y
I
N
G
H
G
D
V
I
G
G
I
-
I
V
G
--
K
Q
E
F
I
D
Q
-
A
R
F
V
--
G
--
L
K
D
I
T
G
G
C
M
S
P
F
N
A
W
L
T
L
R
G
V
K
T
L
G
I
R
M
E
R
H
C
E
N
A
L
K
I
A
R
F
L
E
G
H
P
S
I
T
R
V
Y
Y
----------------
P
------------------
G
LSSHPQ
Y
E
L
G
Q
R
Q
M
SL
P
----------------
G
G
I
I
S
F
E
I
---
A
---
G
G
-
L
E
-
A
G
R
R
M
I
N
S
V
E
L
C
L
L
A
V
S
L
G
D
T
E
T
L
I
Q
H
P
A
S
M
T
H
S
P
V
A
P
E
E
R
L
K
A
G
I
T
D
G
L
I
R
L
S
V
G
L
E
D
P
E
D
I
I
N
D
L
E
H
A
I
--
10
PsiBlast_PDB
77.09
36%
-13
- C1 -
-
5E4Z
3
?
A:
[10-393]
-------
N
T
Q
I
V
H
A
G
Q
Q
P
D
P
S
T
G
A
L
S
--
T
P
I
F
Q
T
S
T
F
V
F
D
S
A
E
Q
--------
G
--
A
--------------
A
R
F
A
LE
E
S
G
Y
I
Y
T
R
L
G
N
P
T
T
D
A
L
E
K
K
L
A
V
L
E
R
G
E
A
G
L
A
T
A
S
G
I
S
A
-
I
T
-
T
T
-
L
L
T
L
-
C
-
Q
Q
G
D
H
I
V
S
A
S
A
I
Y
G
A
T
H
A
F
L
-
S
H
-
S
M
P
--
K
--
F
--
G
---
I
N
V
S
F
V
D
A
A
K
P
--
E
E
I
R
A
----
A
M
---
R
-
P
E
T
K
V
V
Y
I
E
T
P
A
N
P
T
L
S
L
V
D
I
E
T
V
A
G
I
A
H
Q
--
Q
------
G
A
L
L
V
V
D
N
T
F
M
S
P
Y
C
Q
Q
P
L
Q
L
G
A
D
I
V
V
H
S
V
T
K
Y
I
N
G
H
G
D
V
I
G
G
I
-
I
V
G
--
K
Q
E
F
I
D
Q
-
A
R
F
V
--
G
--
L
K
D
I
T
G
G
C
M
S
P
F
N
A
W
L
T
L
R
G
V
K
T
L
G
I
R
M
E
R
H
C
E
N
A
L
K
I
A
R
F
L
E
G
H
P
S
I
T
R
V
Y
Y
----------------
P
------------------
G
LSSHPQ
Y
E
L
G
Q
R
Q
M
SL
P
----------------
G
G
I
I
S
F
E
I
---
A
---
G
G
-
L
E
-
A
G
R
R
M
I
N
S
V
E
L
C
L
L
A
V
S
L
G
D
T
E
T
L
I
Q
H
P
A
S
M
T
H
S
P
V
A
P
E
E
R
L
K
A
G
I
T
D
G
L
I
R
L
S
V
G
L
E
D
P
E
D
I
I
N
D
L
E
H
A
I
--
18
PsiBlast_PDB
76.82
36%
-10
- C1 -
-
5K30
6
?
A:
[10-393]
-------
N
T
Q
I
V
H
A
G
Q
Q
P
D
P
S
T
G
A
L
S
--
T
P
I
F
Q
T
S
T
F
V
F
D
S
A
E
Q
--------
G
--
A
--------------
A
R
F----------
R
L
G
N
P
T
T
D
A
L
E
K
K
L
A
V
L
E
R
G
E
A
G
L
A
T
A
S
G
I
S
A
-
I
T
-
T
T
-
L
L
T
L
-
C
-
Q
Q
G
D
H
I
V
S
A
S
A
I
Y
G
-
T
H
A
F
L
-
S
H
-
S
M
P
--
K
--
F
--
G
---
I
N
V
S
F
V
D
A
A
K
P
--
E
E
I
R
A
----
A
M
---
R
-
P
E
T
K
V
V
Y
I
E
T
P
A
N
P
T
L
S
L
V
D
I
E
T
V
A
G
I
A
H
Q
--
Q
------
G
A
L
L
V
V
D
N
T
F
M
S
P
Y
C
Q
Q
P
L
Q
L
G
A
D
I
V
V
H
S
V
T
K
Y
I
N
G
H
G
D
V
I
G
G
I
-
I
V
G
--
K
Q
E
F
I
D
Q
-
A
R
F
V
--
G
--
L
K
D
I
T
G
G
-
M
S
P
F
N
A
W
L
T
L
R
G
V
K
T
L
G
I
R
M
E
R
H
C
E
N
A
L
K
I
A
R
F
L
E
G
H
P
S
I
T
R
V
Y
Y
----------------
P
------------------
G
LSSHPQ
Y
E
L
G
Q
R
Q
M
SL
P
----------------
G
G
I
I
S
F
E
I
---
A
---
G
G
-
L
E
-
A
G
R
R
M
I
N
S
V
E
L
C
L
L
A
V
S
L
G
D
T
E
T
L
I
Q
H
P
A
S
M
T
H
S
P
V
A
P
E
E
R
L
K
A
G
I
T
D
G
L
I
R
L
S
V
G
L
E
D
P
E
D
I
I
N
D
L
E
H
A
I
--
79
PsiBlast_CBE
76.81
35%
-7
- C1 -
-
1E5E
3
?
B:
[23-393]
----------------------
G
A
A
I
--
P
P
I
Y
Q
T
S
T
F
--
V
F
D
N
C
QQGGNRFA
G
--
Q
--------------
E
------
S
G
Y
I
Y
T
R
L
G
N
P
T
V
S
N
L
E
G
K
I
A
F
L
E
K
T
E
A
C
V
A
T
S
S
G
M
G
A
-
I
A
A
T
V
-
L
-
T
I
-
L
-
K
A
G
D
H
L
I
S
D
E
C
L
Y
G
C
T
H
A
L
F
-
E
H
-
A
L
T
--
K
--
F
--
G
---
I
Q
V
D
F
--
I
N
T
A
IP
G
E
V
K
K
----
H
M
---
K
-
P
N
T
K
I
V
Y
F
E
T
P
A
N
P
T
L
K
I
I
D
M
E
R
V
C
K
D
A
H
S
--
Q
E-----
G
V
L
V
I
A
D
N
T
F
C
S
P
M
I
T
N
P
V
D
F
G
V
D
V
V
V
H
S
A
T
K
Y
I
N
G
H
T
D
V
V
A
G
L
-
I
C
G
--
K
A
D
L
L
Q
Q
-
I
R
M
V
--
G
--
I
K
D
I
T
G
S
V
I
S
P
H
D
A
W
L
I
T
R
G
L
S
T
L
N
I
R
M
K
A
E
S
E
N
A
M
K
V
A
E
Y
L
K
S
H
P
A
V
E
K
V
Y
Y
----------------
P
------------------
G
FEDHEGHDIAKKQMRM
Y
----------------
G
S
M
I
T
F
I
L
---
K
---
S
G
-
F
E
G
A
K
-
K
L
L
D
N
L
K
L
I
T
L
A
V
S
L
G
G
C
E
S
L
I
Q
H
P
A
S
M
T
H
A
V
V
P
K
E
E
R
E
A
A
G
I
T
D
G
M
I
R
L
S
V
G
I
E
D
A
D
E
L
I
A
D
F
K
Q
G
L
D
-
80
PsiBlast_CBE
76.34
35%
-9
- C1 -
-
1E5E
3
?
A:
[23-393]
----------------------
G
A
A
I
--
P
P
I
Y
Q
T
S
T
F
--
V
F
D
N
C
Q
Q
G
G
N
R
F
A
G
--
Q
--------------
E
------
S
G
Y
I
Y
T
R
L
G
N
P
T
V
S
N
L
E
G
K
I
A
F
L
E
K
T
E
A
C
V
A
T
S
S
G
M
G
A
-
I
A
A
T
V
-
L
-
T
I
-
L
-
K
A
G
D
H
L
I
S
D
E
C
L
Y
G
C
T
H
A
L
F
-
E
H
-
A
L
T
--
K
--
F
--
G
---
I
Q
V
D
F
--
I
N
T
A
IP
G
E
V
K
K
----
H
M
---
K
-
P
N
T
K
I
V
Y
F
E
T
P
A
N
P
T
L
K
I
I
D
M
E
R
V
C
K
D
A
H
S
--
Q
E-----
G
V
L
V
I
A
D
N
T
F
C
S
P
M
I
T
N
P
V
D
F
G
V
D
V
V
V
H
S
A
T
K
Y
I
N
G
H
T
D
V
V
A
G
L
-
I
C
G
--
K
A
D
L
L
Q
Q
-
I
R
M
V
--
G
--
I
K
D
I
T
G
S
V
I
S
P
H
D
A
W
L
I
T
R
G
L
S
T
L
N
I
R
M
K
A
E
S
E
N
A
M
K
V
A
E
Y
L
K
S
H
P
A
V
E
K
V
Y
Y
----------------
P
------------------
G
FEDHEG
H
D
I
A
K
K
Q
M
RM
Y
----------------
G
S
M
I
T
F
I
L
---
K
---
S
G
-
F
E
G
A
K
-
K
L
L
D
N
L
K
L
I
T
L
A
V
S
L
G
G
C
E
S
L
I
Q
H
P
A
S
M
T
H
A
V
V
P
K
E
E
R
E
A
A
G
I
T
D
G
M
I
R
L
S
V
G
I
E
D
A
D
E
L
I
A
D
F
K
Q
G
L
D
-
31
PsiBlast_CBE
75.46
38%
-12
- C1 -
-
1IBJ
2
METC_ARATH
C:
[85-460]
----
A
S
V
S
T
L
L
V
N
L
D
N
K
F
D
-
P
F
D
A
M
S
--
T
P
L
Y
Q
T
A
T
F
--
K
Q
P
S
A
--------
I
--
E
--------------
N
------
G
P
Y
D
Y
T
R
S
G
N
P
T
R
D
A
L
E
S
L
L
A
K
L
D
K
A
D
R
A
F
C
F
T
S
G
M
A
A
-
L
S
-
A
V
-
T
-
H
L
-
I
-
K
N
G
E
E
I
V
A
G
D
D
V
Y
G
G
S
D
R
L
L
-
S
Q
-
V
V
P
--
R
--
S
--
G
---
V
V
V
K
R
--
V
N
T
T
KL
D
E
V
A
A
----
A
I
---
G
-
P
Q
T
K
L
V
W
L
E
S
P
T
N
P
R
Q
Q
I
S
D
I
R
K
I
S
E
M
A
H
A
--
Q
------
G
A
L
V
L
V
D
N
S
I
M
S
P
V
L
S
R
P
L
E
L
G
A
D
I
V
M
H
S
A
T
K
F
I
A
G
H
S
D
V
M
A
G
V
-
L
A
V
--
K
G
E
K
L
A
K
-
E
V
Y
F
--
L
--
Q
-
N
S
E
G
S
G
L
A
P
F
D
C
W
L
C
L
R
G
I
K
T
M
A
L
R
I
E
K
Q
Q
E
N
A
R
K
I
A
M
Y
L
S
S
H
P
R
V
K
K
V
Y
Y
----------------
A
GLPDHPGHHLHFSQAK--
G
----------------
A
----------------
G
S
V
F
S
F
I
T
---
G
---
S
V
-
A
L
-
S
K
-
H
L
V
E
T
T
K
Y
F
S
I
A
V
S
F
G
S
V
K
S
L
I
S
M
P
C
F
M
S
H
A
S
I
P
A
E
V
R
E
A
R
G
L
T
E
D
L
V
R
I
S
A
G
I
E
D
V
D
D
L
I
S
D
L
D
I
A
F
K
-
6
PsiBlast_PDB
75.45
38%
-10
- C1 -
-
1IBJ
2
METC_ARATH
A:
[85-460]
----
A
S
V
S
T
L
L
V
N
L
D
N
K
F
D
-
P
F
D
A
M
S
--
T
P
L
Y
Q
T
A
T
F
--
K
Q
P
S
A
--------
I
--
E
--------------
N
------
G
P
Y
D
Y
T
R
S
G
N
P
T
R
D
A
L
E
S
L
L
A
K
L
D
K
A
D
R
A
F
C
F
T
S
G
M
A
A
-
L
S
-
A
V
-
T
-
H
L
-
I
-
K
N
G
E
E
I
V
A
G
D
D
V
Y
G
G
S
D
R
L
L
-
S
Q
-
V
V
P
--
R
--
S
--
G
---
V
V
V
K
R
--
V
N
T
T
K
L
D
E
V
A
A
----
A
I
---
G
-
P
Q
T
K
L
V
W
L
E
S
P
T
N
P
R
Q
Q
I
S
D
I
R
K
I
S
E
M
A
H
A
--
Q
------
G
A
L
V
L
V
D
N
S
I
M
S
P
V
L
S
R
P
L
E
L
G
A
D
I
V
M
H
S
A
T
K
F
I
A
G
H
S
D
V
M
A
G
V
-
L
A
V
--
K
G
E
K
L
A
K
-
E
V
Y
F
--
L
--
Q
-
N
S
E
G
S
G
L
A
P
F
D
C
W
L
C
L
R
G
I
K
T
M
A
L
R
I
E
K
Q
Q
E
N
A
R
K
I
A
M
Y
L
S
S
H
P
R
V
K
K
V
Y
Y
----------------
A
GLPDHPG
H
H
L
H
F
S
Q
A
K--
G
----------------
A
----------------
G
S
V
F
S
F
I
T
---
G
---
S
V
-
A
L
-
S
K
-
H
L
V
E
T
T
K
Y
F
S
I
A
V
S
F
G
S
V
K
S
L
I
S
M
P
C
F
M
S
H
A
S
I
P
A
E
V
R
E
A
R
G
L
T
E
D
L
V
R
I
S
A
G
I
E
D
V
D
D
L
I
S
D
L
D
I
A
F
K
-
112
PsiBlast_CBE
75.39
38%
-11
- C1 -
-
1PFF
18
?
A:
[1-328]
------------------------------------------------------------------------------------------
S
A
L
E
G
K
I
A
K
L
E
H
A
E
A
C
A
A
T
A
S
G
M
G
A
-
I
A
-
A
S
-
V
-
W
T
-
F
L
K
A
G
D
H
L
I
S
D
D
C
L
Y
G
C
T
H
A
L
F
E
H
Q
-
L
R
K
--
F
--
G
V
-
E
---
V
D
F
I
D
--
M
A
V
P
--
G
N
I
E
K
----
H
L
---
K
-
P
N
T
R
I
V
Y
F
E
T
P
A
N
P
T
L
K
V
I
D
I
E
D
A
V
K
Q
A
R
K
Q-
K
------
D
I
L
V
I
V
D
N
T
F
A
S
P
I
L
T
N
P
L
D
L
G
V
D
I
V
V
H
S
A
T
K
Y
I
N
G
H
T
D
V
V
A
G
L
-
V
C
S
--
R
A
-
D
I
I
A
-
K
V
K
S
--
Q
GI
K
-
D
I
T
G
A
I
I
S
P
H
D
A
W
L
I
T
R
G
T
L
T
L
D
M
R
V
K
R
A
A
E
N
A
Q
K
V
A
E
F
L
H
E
H
K
A
V
K
K
V
Y
Y
----------------
P
------------------
G
----------------
L
PDHPG
H
E
I
A
K
K
Q
MKMF
G
S
M
I
A
F
D
V
---
D
---
G
L
-
E
K
-
A
K
-
K
V
L
D
N
C
H
V
V
S
L
A
V
S
L
G
G
P
E
S
L
I
Q
H
P
A
S
M
T
H
A
G
V
P
K
E
E
R
E
A
A
G
L
T
D
N
L
I
R
L
S
V
G
C
E
N
V
Q
D
I
I
D
D
L
K
Q
A
L
D
-
20
PsiBlast_PDB
74.64
37%
-3
- C1 -
-
5DX5
2
?
A:
[5-396]
--
K
K
M
G
F
A
T
K
A
I
H
G
G
H
I
G
D
K
Q
F
G
S
L
A
--
T
P
I
Y
Q
T
S
T
F
--
I
F
D
S
A
E
Q
G
G
R
R
F
A
G
--
E
--------------
E
------
S
G
Y
I
Y
S
R
L
G
N
P
T
S
T
E
V
E
N
K
L
A
L
L
E
G
G
E
A
A
V
V
A
A
S
G
M
G
A
-
I
A
-
A
S
L
W
-
S
A
-
L
-
K
S
G
D
H
V
V
A
S
D
T
L
Y
G
C
T
F
A
L
L
-
N
H
-
G
L
T
--
R
--
Y
--
G
---
V
E
V
T
F
--
V
D
V
S
N
L
D
E
V
K
N
----
A
L
---
K
-
P
N
T
K
V
V
Y
L
E
T
P
A
N
P
T
L
K
V
T
D
I
R
K
I
S
N
M
V
H
E
S
N
K
------
E
C
F
V
F
V
D
N
T
F
C
T
P
Y
I
Q
R
P
L
E
L
G
A
D
V
V
V
H
S
A
T
K
Y
L
N
G
H
G
D
V
I
A
G
F
-
A
V
G
--
K
E
E
F
I
N
Q
V
K
L
F
G
--
I
--
K
-
D
M
T
G
S
V
T
G
P
F
E
S
F
L
I
I
R
G
M
K
T
L
Q
L
R
M
E
K
H
C
K
N
A
M
E
V
A
K
F
L
E
S
H
P
A
V
E
K
V
Y
Y
----------------
P
------------------
G
LESFKY
Y
Q
L
A
R
E
Q
MKL
P
----------------
G
A
M
I
S
F
E
L
KGG
V
---
E
E
-
G
K
-
I
---
V
M
N
N
V
K
L
A
T
L
A
V
S
L
G
D
S
E
T
L
I
Q
H
P
A
S
M
T
H
S
P
Y
T
A
E
E
R
K
A
A
G
I
S
D
G
L
V
R
L
S
V
G
L
E
D
A
E
D
I
I
D
D
L
K
Q
A
L
D
-
149
HHSearch
73.38
41%
10
- C1 -
-
5X5H
4
?
A:
[4-384]
D
P
N
T
Q
G
F
S
T
A
S
I
H
A
G
Y
E
P
D
D
Y
Y
G
S
I
N
--
T
P
I
Y
A
S
T
T
F
--
A
Q
N
A
P
--------
N
--
E
L-------------
R
------
K
G
Y
E
Y
T
R
V
G
N
P
T
I
V
A
L
E
Q
T
V
A
A
L
E
G
A
K
Y
G
R
A
F
S
S
G
M
A
A
-
T
D
-
I
L
-
F
R
I
I
-
L
-
K
P
G
D
H
I
V
L
G
N
D
A
Y
G
G
T
Y
R
L
I
-
D
T
-
V
F
T
--
A
WG
V
--
E
---
Y
T
V
V
D
--
T
S
V
V
--
E
E
V
K
A
----
A
I
---
K
-
D
N
T
K
L
I
W
V
E
T
P
T
N
P
A
L
G
I
T
D
I
E
A
V
A
K
L
T
E
G
--
T
------
N
A
K
L
V
V
D
N
T
F
A
S
P
Y
L
Q
Q
P
L
K
L
G
A
H
A
V
L
H
S
T
T
K
Y
I
G
G
H
S
D
V
V
G
G
L
-
V
V
T
--
N
D
Q
E
M
D
E
-
E
L
L
F
--
M
--
Q
-
G
G
I
G
P
I
P
S
V
F
D
A
Y
L
T
A
R
G
L
K
T
L
A
V
R
M
D
R
H
C
D
N
A
E
K
I
A
E
F
L
D
S
R
P
E
V
S
T
V
L
Y
----------------
P
GLKNHPG
H
E
V
A
A
K
Q
MK--
R
----------------
F
----------------
G
G
M
I
S
V
R
F
---
A
---
G
G
E
E
A
-
A
K
-
K
F
C
T
S
T
K
L
I
C
L
A
E
S
L
G
G
V
E
S
L
L
E
H
P
A
T
M
T
H
Q
S
A
A
---
G
S
Q
L
E
V
P
R
D
L
V
R
I
S
I
G
I
E
D
I
E
D
L
L
A
D
V
E
Q
A
L
N
-
165
HHSearch
72.35
34%
-12
- C1 -
-
5IJG
2
?
B:
[14-426]
--
H
L
L
H
P
E
T
Q
M
L
N
Y
G
Y
D
S
E
L
S
E
G
A
V
K
--
P
P
V
F
L
T
S
T
F
--
V
F
K
T
A
--------
E
--
D
G
R
D
F
F
D
F
V
S
GRKEP---------
L
V
Y
S
R
F
N
H
P
N
S
E
I
V
E
D
R
L
A
V
Y
E
G
A
E
S
A
A
L
F
S
S
G
M
S
A
-
I
A
-
T
T
-
L
F
A
F
-
V
-
R
P
G
D
V
I
L
H
S
Q
P
L
Y
G
G
T
E
T
L
L
-
A
K
-
T
F
F
--
N
F
G
V
--
E
---
A
V
A
F
A
D-
G
V
H
E
--
A
T
I
E
K
A
A
E
E
A
L
---
A
K
G
R
V
S
V
I
L
I
E
T
P
A
N
P
T
N
S
I
V
D
V
A
A
V
R
R
V
A
E
K
--
I
E
A
R
QGS
R
P
V
I
A
C
D
N
T
L
L
G
P
V
F
Q
K
P
L
D
H
G
A
D
L
S
V
Y
S
L
T
K
Y
V
G
G
H
S
D
L
I
A
G
A
-
V
L
G
--
A
-
K
S
V
V
R
-
Q
V
K
A
--
L
--
R
-
G
A
I
G
T
Q
L
D
P
H
S
C
W
M
L
G
R
S
L
E
T
L
G
L
R
M
E
R
A
D
S
N
A
R
A
I
A
E
F
L
R
N
H
P
K
V
E
K
L
H
Y
----------------
L
PFADERS
D
I
A
A
L
F
K
R
Q
C
T
G
----------------
A
----------------
G
S
T
F
S
F
D
I
---
K
---
G
G
Q
A
A
-
A
F
-
R
F
L
N
A
L
Q
I
L
K
L
A
V
---
G
T
E
S
L
A
S
H
P
A
A
-------
V
D
V
R
E
R
I
G
V
L
E
S
T
I
R
L
S
I
G
I
E
H
P
D
D
L
I
A
D
L
A
Q
A
L
D
A
41
PsiBlast_CBE
71.12
37%
2
- C1 -
-
5DX5
2
?
B:
[5-396]
--
K
K
M
G
F
A
T
K
A
I
H
G
G
H
I
G
D
K
Q
F
G
S
L
A
--
T
P
I
Y
Q
T
S
T
F
--
I
F
D
S
A
EQGGRRFA
G
--
E
--------------
E
------
S
G
Y
I
Y
S
R
L
G
N
P
T
S
T
E
V
E
N
K
L
A
L
L
E
G
G
E
A
A
V
V
A
A
S
G
M
G
A
-
I
A
-
A
S
L
W
-
S
A
-
L
-
K
S
G
D
H
V
V
A
S
D
T
L
Y
G
C
T
F
A
L
L
-
N
H
-
G
L
T
--
R
--
Y
--
G
---
V
E
V
T
F
--
V
D
V
S
NL
D
E
V
K
N
----
A
L
---
K
-
P
N
T
K
V
V
Y
L
E
T
P
A
N
P
T
L
K
V
T
D
I
R
K
I
S
N
M
V
H
E
SN
K
------
E
C
F
V
F
V
D
N
T
F
C
T
P
Y
I
Q
R
P
L
E
L
G
A
D
V
V
V
H
S
A
T
K
Y
L
N
G
H
G
D
V
I
A
G
F
-
A
V
G
--
K
E
E
F
I
N
Q
V
K
L
F
G
--
I
--
K
-
D
M
T
G
S
V
T
G
P
F
E
S
F
L
I
I
R
G
M
K
T
L
Q
L
R
M
E
K
H
C
K
N
A
M
E
V
A
K
F
L
E
S
H
P
A
V
E
K
V
Y
Y
----------------
P
------------------
G
LESFKYYQLAREQMKL
P
----------------
G
A
M
I
S
F
E
L
KGG
V
---
E
E
-
G
K
-
I
---
V
M
N
N
V
K
L
A
T
L
A
V
S
L
G
D
S
E
T
L
I
Q
H
P
A
S
M
T
H
S
P
Y
T
A
E
E
R
K
A
A
G
I
S
D
G
L
V
R
L
S
V
G
L
E
D
A
E
D
I
I
D
D
L
K
Q
A
L
D
-
8
PsiBlast_PDB
68.13
40%
13
- C1 -
-
5X5H
4
?
A:
[16-383]
------------
H
A
G
Y
E
P
D
D
Y
Y
G
S
I
N
--
T
P
I
Y
A
S
T
T
F
A
-
Q
N
A
P
N
--------
E
--
L
--------------
R
------
K
G
Y
E
Y
T
R
V
G
N
P
T
I
V
A
L
E
Q
T
V
A
A
L
E
G
A
K
Y
G
R
A
F
S
S
G
M
A
A
-
T
D
-
I
L
-
F
-
R
I
I
L
-
K
P
G
D
H
I
V
L
G
N
D
A
Y
G
G
T
Y
R
L
I
-
D
T
-
V
F
T
--
A
--
W
--
G
---
V
E
Y
T
V
--
V
D
T
S
V
V
E
E
V
K
A
----
A
I
---
K
-
D
N
T
K
L
I
W
V
E
T
P
T
N
P
A
L
G
I
T
D
I
E
A
V
A
K
L
T
E
G
--
T
------
N
A
K
L
V
V
D
N
T
F
A
S
P
Y
L
Q
Q
P
L
K
L
G
A
H
A
V
L
H
S
T
T
K
Y
I
G
G
H
S
D
V
V
G
G
L
-
V
V
T
--
N
D
Q
E
M
D
E
-
E
L
L
F
--
M
--
Q
-
G
G
I
G
P
I
P
S
V
F
D
A
Y
L
T
A
R
G
L
K
T
L
A
V
R
M
D
R
H
C
D
N
A
E
K
I
A
E
F
L
D
S
R
P
E
V
S
T
V
L
Y
----------------
P
------------------
G
----------------
L
KNHPG
H
E
V
A
A
K
Q
MKRF
G
G
M
I
S
V
R
F
---
A
G--
G
E
-
E
A
-
A
K
-
K
F
C
T
S
T
K
L
I
C
L
A
E
S
L
G
G
V
E
S
L
L
E
H
P
A
T
M
T
H
Q
---
S
A
A
G
S
Q
L
E
V
P
R
D
L
V
R
I
S
I
G
I
E
D
I
E
D
L
L
A
D
V
E
Q
A
L
--