@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : spr1399: (2018-01-11 )
MKLSNRVLEMEESVTLAAGARAKALKAEGRDILSLTLGEPDFTTPKNIQDAAIASIRDGRASFYTVTSGLPELKAVVNSYFERFYGYSVASNQVTVAAGAKYSLYTFFMAVVNPGDEVIIPTPYWVSYGDQVKMAEGVPVFVSAKEDNHFKVTVEQLEAARTDKTKVLVLNSPSNPTGMIYTREELLAIGNWAVENDILILADDIYGRLVYNGHEFTPISSLSEAIRKQTVVINGVSKTYAMTGWRIGYAVGEADIIAAMSKIAGQTTSNPSAVAQYAAVEALSGEQDTVESMRQAFEERLNTIYPLLAEVPGFEVVKPQGAFYLFPNVKKAMEMKGYTDVTDFTTAILEEAEVALVTGAGFGAPENVRLSYATDLDTLKEAVERLKAFMGSEND
Atome Classification :
(30 SA)
.........10........20........30........40........50........60........70........80........-90-........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280....---..--.---290.......300.......310.......320....-------...330.......340.......350.......360..--...--..370.......380.......390...
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MKL
S
N
R
V
L
E
M
EES
V
T
LAAGARAKALKAEG
R
D
I
L
S
L
T
LGEPDFTTPKNI
Q
D
A
A
I
A
S
IRDGR
A
S
F
Y
TVTSG
L
P
E
L
K
A
V
V
N
S
Y
F
E
R
F
YGYSV-AS-
N
Q
V
T
V
AAGAK
Y
S
L
Y
T
F
F
M
A
V
VNPGD
E
V
I
I
PT
P
Y
WVSYGD
Q
V
K
MAEGV
P
V
F
V
SAKEDN
H
F
K
V
T
V
E
Q
L
E
AARTDK
T
K
V
L
V
L
NSPSNPT
G
M
I
Y
T
R
E
E
L
L
A
IGNWAVEN
D
I
L
I
L
ADDI
Y
G
R
L
V
YNGHEFT
P
I
S
S
L
S
E
A
I
RK
Q
T
V
V
I
NGVSK
T
Y
A
MTG
W
R
I
G
Y
AVG
E
A
D
I
I
A
A
M
S
K
IAGQTTS
N
P
S
A
V
A
Q
Y
A
A
V
E
ALSG
E
---
Q
D
--
T
---
V
E
S
M
R
Q
A
F
E
E
R
L
N
T
I
Y
P
L
L
AEVPG
F
E
V
VKPQG
A
F
Y
LF-------PN
V
K
K
A
M
EMKGYT
D
V
T
D
F
T
T
A
I
L
EEA
E
V
A
L
V
TGAGFGA--PE
N
--
V
R
L
S
YAT
D
L
D
T
L
K
E
A
V
E
R
L
K
A
F
MGSEND
1
PsiBlast_PDB
94.41
43%
-102
- C1 -
-
1J32
2
?
A:
[1-384]
M
K
L
A
A
R
V
E
S
V
S
P
S
M
T
L
I
I
D
A
K
A
K
A
M
K
A
E
G
I
D
V
C
S
F
S
A
G
E
P
D
F
N
T
P
K
H
I
V
E
A
A
K
A
A
L
E
Q
G
K
T
R
-
Y
G
P
A
A
G
E
P
R
L
R
E
A
I
A
Q
K
L
Q
R
D
N
G
L
C
Y
-
G
A
-
D
N
I
L
V
T
N
G
G
K
Q
S
I
F
N
L
M
L
A
M
I
E
P
G
D
E
V
I
I
P
A
P
F
W
V
S
Y
P
E
M
V
K
L
A
E
G
T
P
V
I
L
P
T
T
V
E
T
Q
F
K
V
S
P
E
Q
I
R
Q
A
I
T
P
K
T
K
L
L
V
F
N
T
P
S
N
P
T
G
M
V
Y
T
P
D
E
V
R
A
I
A
Q
V
A
V
E
A
G
L
W
V
L
S
D
E
I
Y
E
K
I
L
Y
D
D
A
Q
H
L
S
I
G
A
A
S
P
E
A
Y
E
R
S
V
V
C
S
G
F
A
K
T
Y
A
M
T
G
W
R
V
G
F
L
A
G
P
V
P
L
V
K
A
A
T
K
I
Q
G
H
S
T
S
N
V
C
T
F
A
Q
Y
G
A
I
A
A
Y
E
N
S
---
Q
D
--
C
---
V
Q
E
M
L
A
A
F
A
E
R
R
R
Y
M
L
D
A
L
N
A
M
P
G
L
E
C
P
K
P
D
G
A
F
Y
M
F
-------
P
S
I
A
K
T
----
G
R
S
S
L
-
D
F
C
S
E
L
L
D
Q
H
Q
V
A
T
V
P
G
A
A
F
G
A
--
D
D
C
--
I
R
L
S
Y
A
T
D
L
D
T
I
K
R
G
M
E
R
L
E
K
F
L
-----
21
PsiBlast_CBE
93.38
43%
-104
- C1 -
-
1J32
2
?
B:
[1-384]
M
K
L
A
A
R
V
E
S
V
S
P
S
M
T
L
I
I
D
A
K
A
K
A
M
K
A
E
G
I
D
V
C
S
F
S
A
G
E
P
D
F
N
T
P
K
H
I
V
E
A
A
K
A
A
L
E
Q
G
K
T
R
-
Y
G
P
A
A
G
E
P
R
L
R
E
A
I
A
Q
K
L
Q
R
D
N
G
L
C
Y
-
G
A
-
D
N
I
L
V
T
N
G
G
K
Q
S
I
F
N
L
M
L
A
M
I
E
P
G
D
E
V
I
I
P
A
P
F
W
V
S
Y
P
E
M
V
K
L
A
E
G
T
P
V
I
L
P
T
T
V
E
T
Q
F
K
V
S
P
E
Q
I
R
Q
A
I
T
P
K
T
K
L
L
V
F
N
T
P
S
N
P
T
G
M
V
Y
T
P
D
E
V
R
A
I
A
Q
V
A
V
E
A
G
L
W
V
L
S
D
E
I
Y
E
K
I
L
Y
D
D
A
Q
H
L
S
I
G
A
A
S
P
E
A
Y
E
R
S
V
V
C
S
G
F
A
K
T
Y
A
M
T
G
W
R
V
G
F
L
A
G
P
V
P
L
V
K
A
A
T
K
I
Q
G
H
S
T
S
N
V
C
T
F
A
Q
Y
G
A
I
A
A
Y
E
N
S
---
Q
D
--
C
---
V
Q
E
M
L
A
A
F
A
E
R
R
R
Y
M
L
D
A
L
N
A
M
P
G
L
E
C
P
K
P
D
G
A
F
Y
M
F
-------
P
S
I
A
K
T
----
G
R
S
S
L
-
D
F
C
S
E
L
L
D
Q
H
Q
V
A
T
V
P
G
A
A
F
G
A
--
D
D
C
--
I
R
L
S
Y
A
T
D
L
D
T
I
K
R
G
M
E
R
L
E
K
F
L
-----
56
HHSearch
92.95
44%
-103
- C1 -
-
1J32
2
?
B:
[1-386]
M
K
L
A
A
R
V
E
S
V
S
P
S
M
T
L
I
I
D
A
K
A
K
A
M
K
A
E
G
I
D
V
C
S
F
S
A
G
E
P
D
F
N
T
P
K
H
I
V
E
A
A
K
A
A
L
E
-
Q
G
K
T
R
Y
G
P
A
A
G
E
P
R
L
R
E
A
I
A
Q
K
L
Q
R
D
N
G
L
C
Y
-
G
A
-
D
N
I
L
V
T
N
G
G
K
Q
S
I
F
N
L
M
L
A
M
I
E
P
G
D
E
V
I
I
P
A
P
F
W
V
S
Y
P
E
M
V
K
L
A
E
G
T
P
V
I
L
P
T
T
V
E
T
Q
F
K
V
S
P
E
Q
I
R
Q
A
I
T
P
K
T
K
L
L
V
F
N
T
P
S
N
P
T
G
M
V
Y
T
P
D
E
V
R
A
I
A
Q
V
A
V
E
A
G
L
W
V
L
S
D
E
I
Y
E
K
I
L
Y
D
D
A
Q
H
L
S
I
G
A
A
S
P
E
A
Y
E
R
S
V
V
C
S
G
F
A
K
T
Y
A
M
T
G
W
R
V
G
F
L
A
G
P
V
P
L
V
K
A
A
T
K
I
Q
G
H
S
T
S
N
V
C
T
F
A
Q
Y
G
A
I
A
A
Y
E
N
S
---
Q
D
--
C
---
V
Q
E
M
L
A
A
F
A
E
R
R
R
Y
M
L
D
A
L
N
A
M
P
G
L
E
C
P
K
P
D
G
A
F
Y
M
F
-------
P
S
I
A
K
T
G
R
S
S
-----
L
D
F
C
S
E
L
L
D
Q
H
Q
V
A
T
V
P
G
A
A
F
G
A
--
D
D
C
--
I
R
L
S
Y
A
T
D
L
D
T
I
K
R
G
M
E
R
L
E
K
F
L
H
G
---
43
PsiBlast_CBE
89.23
39%
-108
- C1 -
-
1O4S
2
AAT_THEMA
B:
[14-388]
--
V
S
R
R
I
S
E
I
P
I
S
K
T
M
E
L
D
A
K
A
K
A
L
I
K
K
G
E
D
V
I
N
L
T
A
G
E
P
D
F
P
T
P
E
P
V
V
E
E
A
V
R
F
L
Q
K
G
E
V
K
-
Y
T
D
P
R
G
I
Y
E
L
R
E
G
I
A
K
R
I
G
E
R
Y
K
K
D
I
-
S
P
-
D
Q
V
V
V
T
N
G
A
K
Q
A
L
F
N
A
F
M
A
L
L
D
P
G
D
E
V
I
V
F
S
P
V
W
V
S
Y
I
P
Q
I
I
L
A
G
G
T
V
N
V
V
E
T
F
M
S
K
N
F
Q
P
S
L
E
E
V
E
G
L
L
V
G
K
T
K
A
V
L
I
N
S
P
N
N
P
T
G
V
V
Y
R
R
E
F
L
E
G
L
V
R
L
A
K
K
R
N
F
Y
I
I
S
D
E
V
Y
D
S
L
V
Y
T
-
D
E
F
T
S
I
L
D
V
S
E
G
F
-
D
R
I
V
Y
I
N
G
F
S
K
S
H
S
M
T
G
W
R
V
G
Y
L
I
S
S
E
K
V
A
T
A
V
S
K
I
Q
S
H
T
T
S
C
I
N
T
V
A
Q
Y
A
A
L
K
A
L
E
V
D
---
N
S
--
Y
------
M
V
Q
T
F
K
E
R
K
N
F
V
V
E
R
L
K
K
M
-
G
V
K
F
V
E
P
E
G
A
F
Y
L
F
-------
F
K
V
R
--------
G
D
D
V
K
F
C
E
R
L
L
E
E
K
K
V
A
L
V
P
G
S
A
F
L
K
--
P
G
F
--
V
R
L
S
F
A
T
S
I
E
R
L
T
E
A
L
D
R
I
E
D
F
L
N
S
---
72
HHSearch
88.45
40%
-108
- C1 -
-
1O4S
2
AAT_THEMA
B:
[14-388]
--
V
S
R
R
I
S
E
I
P
I
S
K
T
M
E
L
D
A
K
A
K
A
L
I
K
K
G
E
D
V
I
N
L
T
A
G
E
P
D
F
P
T
P
E
P
V
V
E
E
A
V
R
F
L
Q
-
K
G
E
V
K
Y
T
D
P
R
G
I
Y
E
L
R
E
G
I
A
K
R
I
G
E
R
Y
K
K
D
I
-
S
P
-
D
Q
V
V
V
T
N
G
A
K
Q
A
L
F
N
A
F
M
A
L
L
D
P
G
D
E
V
I
V
F
S
P
V
W
V
S
Y
I
P
Q
I
I
L
A
G
G
T
V
N
V
V
E
T
F
M
S
K
N
F
Q
P
S
L
E
E
V
E
G
L
L
V
G
K
T
K
A
V
L
I
N
S
P
N
N
P
T
G
V
V
Y
R
R
E
F
L
E
G
L
V
R
L
A
K
K
R
N
F
Y
I
I
S
D
E
V
Y
D
S
L
V
Y
T
D
E
-
F
T
S
I
L
D
V
S
E
-
G
F
D
R
I
V
Y
I
N
G
F
S
K
S
H
S
M
T
G
W
R
V
G
Y
L
I
S
S
E
K
V
A
T
A
V
S
K
I
Q
S
H
T
T
S
C
I
N
T
V
A
Q
Y
A
A
L
K
A
L
E
V
D
-----------
N
S
Y
M
V
Q
T
F
K
E
R
K
N
F
V
V
E
R
L
K
K
M
-
G
V
K
F
V
E
P
E
G
A
F
Y
L
F
-------
F
K
V
R
G
D
D
--
V
------
K
F
C
E
R
L
L
E
E
K
K
V
A
L
V
P
G
S
A
F
L
K
--
P
G
F
--
V
R
L
S
F
A
T
S
I
E
R
L
T
E
A
L
D
R
I
E
D
F
L
N
S
---
11
PsiBlast_PDB
85.66
39%
-105
- C1 -
-
1O4S
2
AAT_THEMA
A:
[14-388]
--
V
S
R
R
I
S
E
I
P
I
S
K
T
M
E
L
D
A
K
A
K
A
L
I
K
K
G
E
D
V
I
N
L
T
A
G
E
P
D
F
P
T
P
E
P
V
V
E
E
A
V
R
F
L
Q
K
G
E
V
K
-
Y
T
D
P
R
G
I
Y
E
L
R
E
G
I
A
K
R
I
G
E
R
Y
K
K
D
I
-
S
P
-
D
Q
V
V
V
T
N
G
A
K
Q
A
L
F
N
A
F
M
A
L
L
D
P
G
D
E
V
I
V
F
S
P
V
W
V
S
Y
I
P
Q
I
I
L
A
G
G
T
V
N
V
V
E
T
F
M
S
K
N
F
Q
P
S
L
E
E
V
E
G
L
L
V
G
K
T
K
A
V
L
I
N
S
P
N
N
P
T
G
V
V
Y
R
R
E
F
L
E
G
L
V
R
L
A
K
K
R
N
F
Y
I
I
S
D
E
V
Y
D
S
L
V
Y
T
-
D
E
F
T
S
I
L
D
V
S
E
G
F
-
D
R
I
V
Y
I
N
G
F
S
K
S
H
S
M
T
G
W
R
V
G
Y
L
I
S
S
E
K
V
A
T
A
V
S
K
I
Q
S
H
T
T
S
C
I
N
T
V
A
Q
Y
A
A
L
K
A
L
E
V
D
---
N
S
--
Y
------
M
V
Q
T
F
K
E
R
K
N
F
V
V
E
R
L
K
K
M
-
G
V
K
F
V
E
P
E
G
A
F
Y
L
F
-------
F
K
V
R
--------
G
D
D
V
K
F
C
E
R
L
L
E
E
K
K
V
A
L
V
P
G
S
A
F
L
K
--
P
G
F
--
V
R
L
S
F
A
T
S
I
E
R
L
T
E
A
L
D
R
I
E
D
F
L
N
S
---
8
PsiBlast_PDB
82.05
38%
-66
- C1 -
-
1GC4
4
AAT_THET8
A:
[4-382]
--
L
S
R
R
V
Q
A
M
K
P
D
A
V
V
A
V
N
A
K
A
L
E
L
R
R
Q
G
V
D
L
V
A
L
T
A
G
E
P
D
F
D
T
P
E
H
V
K
E
A
A
R
R
A
L
A
Q
G
K
T
K
-
Y
A
P
P
A
G
I
P
E
L
R
E
A
L
A
E
K
F
R
R
E
N
G
L
S
V
-
T
P
-
E
E
T
I
V
T
V
G
G
S
Q
A
L
F
N
L
F
Q
A
I
L
D
P
G
D
E
V
I
V
L
S
P
Y
W
V
S
Y
P
E
M
V
R
F
A
G
G
V
V
V
E
V
E
T
L
P
E
E
G
F
V
P
D
P
E
R
V
R
R
A
I
T
P
R
T
K
A
L
V
V
N
S
P
N
N
P
T
G
A
V
Y
P
K
E
V
L
E
A
L
A
R
L
A
V
E
H
D
F
Y
L
V
S
D
E
I
Y
E
H
L
L
Y
E
G
E
H
F
S
P
G
R
V
A
P
E
----
H
T
L
T
V
N
G
A
A
K
A
F
A
M
T
G
W
R
I
G
Y
A
C
G
P
K
E
V
I
K
A
M
A
S
V
S
R
Q
S
T
T
S
P
D
T
I
A
Q
W
A
T
L
E
A
L
T
N
Q
---
E
A
--
S
R
A
F
V
E
M
A
R
E
A
Y
R
R
R
R
D
L
L
L
E
G
L
T
A
L
-
G
L
K
A
V
R
P
S
G
A
F
Y
V
L
M
D
TSPIA
P
D
E
V
R
A
A
E
R
-------------
L
L
E
A
G
V
A
V
V
P
G
T
D
F
A
A
--
F
G
H
--
V
R
L
S
Y
A
T
S
E
E
N
L
R
K
A
L
E
R
F
A
R
V
L
-----
5
PsiBlast_PDB
80.89
38%
-60
- C1 -
-
1B5P
2
AAT_THET8
A:
[4-382]
--
L
S
R
R
V
Q
A
M
K
P
S
A
T
V
A
V
N
A
K
A
L
E
L
R
R
Q
G
V
D
L
V
A
L
T
A
G
E
P
D
F
D
T
P
E
H
V
K
E
A
A
R
R
A
L
A
Q
G
K
T
K
-
Y
A
P
P
A
G
I
P
E
L
R
E
A
L
A
E
K
F
R
R
E
N
G
L
S
V
-
T
P
-
E
E
T
I
V
T
V
G
G
S
Q
A
L
F
N
L
F
Q
A
I
L
D
P
G
D
E
V
I
V
L
S
P
Y
W
V
S
Y
P
E
M
V
R
F
A
G
G
V
V
V
E
V
E
T
L
P
E
E
G
F
V
P
D
P
E
R
V
R
R
A
I
T
P
R
T
K
A
L
V
V
N
S
P
N
N
P
T
G
A
V
Y
P
K
E
V
L
E
A
L
A
R
L
A
V
E
H
D
F
Y
L
V
S
D
E
I
Y
E
H
L
L
Y
E
G
E
H
F
S
P
G
R
V
A
P
E
----
H
T
L
T
V
N
G
A
A
K
A
F
A
M
T
G
W
R
I
G
Y
A
C
G
P
K
E
V
I
K
A
M
A
S
V
S
R
Q
S
T
T
S
P
D
T
I
A
Q
W
A
T
L
E
A
L
T
N
Q
---
E
A
--
S
R
A
F
V
E
M
A
R
E
A
Y
R
R
R
R
D
L
L
L
E
G
L
T
A
L
-
G
L
K
A
V
R
P
S
G
A
F
Y
V
L
M
D
TSPIA
P
D
E
V
R
A
A
E
R
-------------
L
L
E
A
G
V
A
V
V
P
G
T
D
F
A
A
--
F
G
H
--
V
R
L
S
Y
A
T
S
E
E
N
L
R
K
A
L
E
R
F
A
R
V
L
-----
31
PsiBlast_CBE
80.82
38%
-66
- C1 -
-
1GC4
4
AAT_THET8
B:
[4-382]
--
L
S
R
R
V
Q
A
M
K
P
D
A
V
V
A
V
N
A
K
A
L
E
L
R
R
Q
G
V
D
L
V
A
L
T
A
G
E
P
D
F
D
T
P
E
H
V
K
E
A
A
R
R
A
L
A
Q
G
K
T
K
-
Y
A
P
P
A
G
I
P
E
L
R
E
A
L
A
E
K
F
R
R
E
N
G
L
S
V
-
T
P
-
E
E
T
I
V
T
V
G
G
S
Q
A
L
F
N
L
F
Q
A
I
L
D
P
G
D
E
V
I
V
L
S
P
Y
W
V
S
Y
P
E
M
V
R
F
A
G
G
V
V
V
E
V
E
T
L
P
E
E
G
F
V
P
D
P
E
R
V
R
R
A
I
T
P
R
T
K
A
L
V
V
N
S
P
N
N
P
T
G
A
V
Y
P
K
E
V
L
E
A
L
A
R
L
A
V
E
H
D
F
Y
L
V
S
D
E
I
Y
E
H
L
L
Y
E
G
E
H
F
S
P
G
R
V
A
P
E
----
H
T
L
T
V
N
G
A
A
K
A
F
A
M
T
G
W
R
I
G
Y
A
C
G
P
K
E
V
I
K
A
M
A
S
V
S
R
Q
S
T
T
S
P
D
T
I
A
Q
W
A
T
L
E
A
L
T
N
Q
---
E
A
--
S
RAF
V
E
M
A
R
E
A
Y
R
R
R
R
D
L
L
L
E
G
L
T
A
L
-
G
L
K
A
V
R
P
S
G
A
F
Y
V
L
MDTSPIA
P
D
E
V
R
A
A
E
R
-------------
L
L
E
A
G
V
A
V
V
P
G
T
D
F
A
A
--
F
G
H
--
V
R
L
S
Y
A
T
S
E
E
N
L
R
K
A
L
E
R
F
A
R
V
L
-----
25
PsiBlast_CBE
80.31
38%
-61
- C1 -
-
1B5O
2
AAT_THET8
B:
[4-382]
--
L
S
R
R
V
Q
A
M
K
P
S
A
T
V
A
V
N
A
K
A
L
E
L
R
R
Q
G
V
D
L
V
A
L
T
A
G
E
P
D
F
D
T
P
E
H
V
K
E
A
A
R
R
A
L
A
Q
G
K
T
K
-
Y
A
P
P
A
G
I
P
E
L
R
E
A
L
A
E
K
F
R
R
E
N
G
L
S
V
-
T
P
-
E
E
T
I
V
T
V
G
G
S
Q
A
L
F
N
L
F
Q
A
I
L
D
P
G
D
E
V
I
V
L
S
P
Y
W
V
S
Y
P
E
M
V
R
F
A
G
G
V
V
V
E
V
E
T
L
P
E
E
G
F
V
P
D
P
E
R
V
R
R
A
I
T
P
R
T
K
A
L
V
V
N
S
P
N
N
P
T
G
A
V
Y
P
K
E
V
L
E
A
L
A
R
L
A
V
E
H
D
F
Y
L
V
S
D
E
I
Y
E
H
L
L
Y
E
G
E
H
F
S
P
G
R
V
A
P
E
----
H
T
L
T
V
N
G
A
A
K
A
F
A
M
T
G
W
R
I
G
Y
A
C
G
P
K
E
V
I
K
A
M
A
S
V
S
S
Q
S
T
T
S
P
D
T
I
A
Q
W
A
T
L
E
A
L
T
N
Q
---
E
A
--
S
RAF
V
E
M
A
R
E
A
Y
R
R
R
R
D
L
L
L
E
G
L
T
A
L
-
G
L
K
A
V
R
P
S
G
A
F
Y
V
L
MDTSPIA
P
D
E
V
R
A
A
E
R
-------------
L
L
E
A
G
V
A
V
V
P
G
T
D
F
A
A
--
F
G
H
--
V
R
L
S
Y
A
T
S
E
E
N
L
R
K
A
L
E
R
F
A
R
V
L
-----
29
PsiBlast_CBE
80.28
38%
-67
- C1 -
-
1GC4
4
AAT_THET8
D:
[4-382]
--
L
S
R
R
V
Q
A
M
K
P
D
A
V
V
A
V
N
A
K
A
L
E
L
R
R
Q
G
V
D
L
V
A
L
T
A
G
E
P
D
F
D
T
P
E
H
V
K
E
A
A
R
R
A
L
A
Q
G
K
T
K
-
Y
A
P
P
A
G
I
P
E
L
R
E
A
L
A
E
K
F
R
R
E
N
G
L
S
V
-
T
P
-
E
E
T
I
V
T
V
G
G
S
Q
A
L
F
N
L
F
Q
A
I
L
D
P
G
D
E
V
I
V
L
S
P
Y
W
V
S
Y
P
E
M
V
R
F
A
G
G
V
V
V
E
V
E
T
L
P
E
E
G
F
V
P
D
P
E
R
V
R
R
A
I
T
P
R
T
K
A
L
V
V
N
S
P
N
N
P
T
G
A
V
Y
P
K
E
V
L
E
A
L
A
R
L
A
V
E
H
D
F
Y
L
V
S
D
E
I
Y
E
H
L
L
Y
E
G
E
H
F
S
P
G
R
V
A
P
E
----
H
T
L
T
V
N
G
A
A
K
A
F
A
M
T
G
W
R
I
G
Y
A
C
G
P
K
E
V
I
K
A
M
A
S
V
S
R
Q
S
T
T
S
P
D
T
I
A
Q
W
A
T
L
E
A
L
T
N
Q
---
E
A
--
S
RAF
V
E
M
A
R
E
A
Y
R
R
R
R
D
L
L
L
E
G
L
T
A
L
-
G
L
K
A
V
R
P
S
G
A
F
Y
V
L
MDTSPIA
P
D
E
V
R
A
A
E
R
-------------
L
L
E
A
G
V
A
V
V
P
G
T
D
F
A
A
--
F
G
H
--
V
R
L
S
Y
A
T
S
E
E
N
L
R
K
A
L
E
R
F
A
R
V
L
-----
3
PsiBlast_PDB
80.00
38%
-61
- C1 -
-
1B5O
2
AAT_THET8
A:
[4-382]
--
L
S
R
R
V
Q
A
M
K
P
S
A
T
V
A
V
N
A
K
A
L
E
L
R
R
Q
G
V
D
L
V
A
L
T
A
G
E
P
D
F
D
T
P
E
H
V
K
E
A
A
R
R
A
L
A
Q
G
K
T
K
-
Y
A
P
P
A
G
I
P
E
L
R
E
A
L
A
E
K
F
R
R
E
N
G
L
S
V
-
T
P
-
E
E
T
I
V
T
V
G
G
S
Q
A
L
F
N
L
F
Q
A
I
L
D
P
G
D
E
V
I
V
L
S
P
Y
W
V
S
Y
P
E
M
V
R
F
A
G
G
V
V
V
E
V
E
T
L
P
E
E
G
F
V
P
D
P
E
R
V
R
R
A
I
T
P
R
T
K
A
L
V
V
N
S
P
N
N
P
T
G
A
V
Y
P
K
E
V
L
E
A
L
A
R
L
A
V
E
H
D
F
Y
L
V
S
D
E
I
Y
E
H
L
L
Y
E
G
E
H
F
S
P
G
R
V
A
P
E
----
H
T
L
T
V
N
G
A
A
K
A
F
A
M
T
G
W
R
I
G
Y
A
C
G
P
K
E
V
I
K
A
M
A
S
V
S
S
Q
S
T
T
S
P
D
T
I
A
Q
W
A
T
L
E
A
L
T
N
Q
---
E
A
--
S
R
A
F
V
E
M
A
R
E
A
Y
R
R
R
R
D
L
L
L
E
G
L
T
A
L
-
G
L
K
A
V
R
P
S
G
A
F
Y
V
L
M
D
TSPIA
P
D
E
V
R
A
A
E
R
-------------
L
L
E
A
G
V
A
V
V
P
G
T
D
F
A
A
--
F
G
H
--
V
R
L
S
Y
A
T
S
E
E
N
L
R
K
A
L
E
R
F
A
R
V
L
-----
30
PsiBlast_CBE
79.78
38%
-67
- C1 -
-
1GC4
4
AAT_THET8
C:
[4-382]
--
L
S
R
R
V
Q
A
M
K
P
D
A
V
V
A
V
N
A
K
A
L
E
L
R
R
Q
G
V
D
L
V
A
L
T
A
G
E
P
D
F
D
T
P
E
H
V
K
E
A
A
R
R
A
L
A
Q
G
K
T
K
-
Y
A
P
P
A
G
I
P
E
L
R
E
A
L
A
E
K
F
R
R
E
N
G
L
S
V
-
T
P
-
E
E
T
I
V
T
V
G
G
S
Q
A
L
F
N
L
F
Q
A
I
L
D
P
G
D
E
V
I
V
L
S
P
Y
W
V
S
Y
P
E
M
V
R
F
A
G
G
V
V
V
E
V
E
T
L
P
E
E
G
F
V
P
D
P
E
R
V
R
R
A
I
T
P
R
T
K
A
L
V
V
N
S
P
N
N
P
T
G
A
V
Y
P
K
E
V
L
E
A
L
A
R
L
A
V
E
H
D
F
Y
L
V
S
D
E
I
Y
E
H
L
L
Y
E
G
E
H
F
S
P
G
R
V
A
P
E
----
H
T
L
T
V
N
G
A
A
K
A
F
A
M
T
G
W
R
I
G
Y
A
C
G
P
K
E
V
I
K
A
M
A
S
V
S
R
Q
S
T
T
S
P
D
T
I
A
Q
W
A
T
L
E
A
L
T
N
Q
---
E
A
--
S
RAF
V
E
M
A
R
E
A
Y
R
R
R
R
D
L
L
L
E
G
L
T
A
L
-
G
L
K
A
V
R
P
S
G
A
F
Y
V
L
MDTSPIA
P
D
E
V
R
A
A
E
R
-------------
L
L
E
A
G
V
A
V
V
P
G
T
D
F
A
A
--
F
G
H
--
V
R
L
S
Y
A
T
S
E
E
N
L
R
K
A
L
E
R
F
A
R
V
L
-----
34
PsiBlast_CBE
79.21
38%
-64
- C1 -
-
1GC3
4
AAT_THET8
F:
[4-382]
--
L
S
R
R
V
Q
A
M
K
P
D
A
V
V
A
V
N
A
K
A
L
E
L
R
R
Q
G
V
D
L
V
A
L
T
A
G
E
P
D
F
D
T
P
E
H
V
K
E
A
A
R
R
A
L
A
Q
G
K
T
K
-
Y
A
P
P
A
G
I
P
E
L
R
E
A
L
A
E
K
F
R
R
E
N
G
L
S
V
-
T
P
-
E
E
T
I
V
T
V
G
G
S
Q
A
L
F
N
L
F
Q
A
I
L
D
P
G
D
E
V
I
V
L
S
P
Y
W
V
S
Y
P
E
M
V
R
F
A
G
G
V
V
V
E
V
E
T
L
P
E
E
G
F
V
P
D
P
E
R
V
R
R
A
I
T
P
R
T
K
A
L
V
V
N
S
P
N
N
P
T
G
A
V
Y
P
K
E
V
L
E
A
L
A
R
L
A
V
E
H
D
F
Y
L
V
S
D
E
I
Y
E
H
L
L
Y
E
G
E
H
F
S
P
G
R
V
A
P
E
----
H
T
L
T
V
N
G
A
A
K
A
F
A
M
T
G
W
R
I
G
Y
A
C
G
P
K
E
V
I
K
A
M
A
S
V
S
R
Q
S
T
T
S
P
D
T
I
A
Q
W
A
T
L
E
A
L
T
N
Q
---
E
A
--
S
RAF
V
E
M
A
R
E
A
Y
R
R
R
R
D
L
L
L
E
G
L
T
A
L
-
G
L
K
A
V
R
P
S
G
A
F
Y
V
L
MDTSPIA
P
D
E
V
R
A
A
E
R
-------------
L
L
E
A
G
V
A
V
V
P
G
T
D
F
A
A
--
F
G
H
--
V
R
L
S
Y
A
T
S
E
E
N
L
R
K
A
L
E
R
F
A
R
V
L
-----
36
PsiBlast_CBE
79.13
38%
-63
- C1 -
-
1GC3
4
AAT_THET8
D:
[4-382]
--
L
S
R
R
V
Q
A
M
K
P
D
A
V
V
A
V
N
A
K
A
L
E
L
R
R
Q
G
V
D
L
V
A
L
T
A
G
E
P
D
F
D
T
P
E
H
V
K
E
A
A
R
R
A
L
A
Q
G
K
T
K
-
Y
A
P
P
A
G
I
P
E
L
R
E
A
L
A
E
K
F
R
R
E
N
G
L
S
V
-
T
P
-
E
E
T
I
V
T
V
G
G
S
Q
A
L
F
N
L
F
Q
A
I
L
D
P
G
D
E
V
I
V
L
S
P
Y
W
V
S
Y
P
E
M
V
R
F
A
G
G
V
V
V
E
V
E
T
L
P
E
E
G
F
V
P
D
P
E
R
V
R
R
A
I
T
P
R
T
K
A
L
V
V
N
S
P
N
N
P
T
G
A
V
Y
P
K
E
V
L
E
A
L
A
R
L
A
V
E
H
D
F
Y
L
V
S
D
E
I
Y
E
H
L
L
Y
E
G
E
H
F
S
P
G
R
V
A
P
E
----
H
T
L
T
V
N
G
A
A
K
A
F
A
M
T
G
W
R
I
G
Y
A
C
G
P
K
E
V
I
K
A
M
A
S
V
S
R
Q
S
T
T
S
P
D
T
I
A
Q
W
A
T
L
E
A
L
T
N
Q
---
E
A
--
S
RAF
V
E
M
A
R
E
A
Y
R
R
R
R
D
L
L
L
E
G
L
T
A
L
-
G
L
K
A
V
R
P
S
G
A
F
Y
V
L
MDTSPIA
P
D
E
V
R
A
A
E
R
-------------
L
L
E
A
G
V
A
V
V
P
G
T
D
F
A
A
--
F
G
H
--
V
R
L
S
Y
A
T
S
E
E
N
L
R
K
A
L
E
R
F
A
R
V
L
-----
27
PsiBlast_CBE
78.77
38%
-60
- C1 -
-
1B5P
2
AAT_THET8
B:
[4-382]
--
L
S
R
R
V
Q
A
M
K
P
S
A
T
V
A
V
N
A
K
A
L
E
L
R
R
Q
G
V
D
L
V
A
L
T
A
G
E
P
D
F
D
T
P
E
H
V
K
E
A
A
R
R
A
L
A
Q
G
K
T
K
-
Y
A
P
P
A
G
I
P
E
L
R
E
A
L
A
E
K
F
R
R
E
N
G
L
S
V
-
T
P
-
E
E
T
I
V
T
V
G
G
S
Q
A
L
F
N
L
F
Q
A
I
L
D
P
G
D
E
V
I
V
L
S
P
Y
W
V
S
Y
P
E
M
V
R
F
A
G
G
V
V
V
E
V
E
T
L
P
E
E
G
F
V
P
D
P
E
R
V
R
R
A
I
T
P
R
T
K
A
L
V
V
N
S
P
N
N
P
T
G
A
V
Y
P
K
E
V
L
E
A
L
A
R
L
A
V
E
H
D
F
Y
L
V
S
D
E
I
Y
E
H
L
L
Y
E
G
E
H
F
S
P
G
R
V
A
P
E
----
H
T
L
T
V
N
G
A
A
K
A
F
A
M
T
G
W
R
I
G
Y
A
C
G
P
K
E
V
I
K
A
M
A
S
V
S
R
Q
S
T
T
S
P
D
T
I
A
Q
W
A
T
L
E
A
L
T
N
Q
---
E
A
--
S
RAF
V
E
M
A
R
E
A
Y
R
R
R
R
D
L
L
L
E
G
L
T
A
L
-
G
L
K
A
V
R
P
S
G
A
F
Y
V
L
MDTSPIA
P
D
E
V
R
A
A
E
R
-------------
L
L
E
A
G
V
A
V
V
P
G
T
D
F
A
A
--
F
G
H
--
V
R
L
S
Y
A
T
S
E
E
N
L
R
K
A
L
E
R
F
A
R
V
L
-----
6
PsiBlast_PDB
78.02
38%
-60
- C1 -
-
1BJW
-
AAT_THET8
A:
[4-378]
--
L
S
R
R
V
Q
A
M
K
P
S
A
T
V
A
V
N
A
K
A
L
E
L
R
R
Q
G
V
D
L
V
A
L
T
A
G
E
P
D
F
D
T
P
E
H
V
K
E
A
A
R
R
A
L
A
Q
G
K
T
K
-
Y
A
P
P
A
G
I
P
E
L
R
E
A
L
A
E
K
F
R
R
E
N
G
L
S
V
-
T
P
-
E
E
T
I
V
T
V
G
G
K
Q
A
L
F
N
L
F
Q
A
I
L
D
P
G
D
E
V
I
V
L
S
P
Y
W
V
S
Y
P
E
M
V
R
F
A
G
G
V
V
V
E
V
E
T
L
P
E
E
G
F
V
P
D
P
E
R
V
R
R
A
I
T
P
R
T
K
A
L
V
V
N
S
P
N
N
P
T
G
A
V
Y
P
K
E
V
L
E
A
L
A
R
L
A
V
E
H
D
F
Y
L
V
S
D
E
I
Y
E
H
L
L
Y
E
G
E
H
F
S
P
G
R
V
A
P
E
----
H
T
L
T
V
N
G
A
A
K
A
F
A
M
T
G
W
R
I
G
Y
A
C
G
P
K
E
V
I
K
A
M
A
S
V
S
S
Q
S
T
T
S
P
D
T
I
A
Q
W
A
T
L
E
A
L
T
N
Q
---
E
A
--
S
R
A
F
V
E
M
A
R
E
A
Y
R
R
R
R
D
L
L
L
E
G
L
T
A
L
-
G
L
K
A
V
R
P
S
G
A
F
Y
V
L
M
DTSPIA
P
D
E
V
R
A
A
E
R
-------------
L
L
E
A
G
V
A
V
V
P
G
T
D
F
A
A
--
F
G
H
--
V
R
L
S
Y
A
T
S
E
E
N
L
R
K
A
L
E
R
F
---------
64
HHSearch
77.95
39%
-64
* C1 *
-
1B5P
2
AAT_THET8
B:
[4-382]
--
L
S
R
R
V
Q
A
M
K
P
S
A
T
V
A
V
N
A
K
A
L
E
L
R
R
Q
G
V
D
L
V
A
L
T
A
G
E
P
D
F
D
T
P
E
H
V
K
E
A
A
R
R
A
L
A
-
Q
G
K
T
K
Y
A
P
P
A
G
I
P
E
L
R
E
A
L
A
E
K
F
R
R
E
N
G
L
S
V
-
T
P
-
E
E
T
I
V
T
V
G
G
S
Q
A
L
F
N
L
F
Q
A
I
L
D
P
G
D
E
V
I
V
L
S
P
Y
W
V
S
Y
P
E
M
V
R
F
A
G
G
V
V
V
E
V
E
T
L
P
E
E
G
F
V
P
D
P
E
R
V
R
R
A
I
T
P
R
T
K
A
L
V
V
N
S
P
N
N
P
T
G
A
V
Y
P
K
E
V
L
E
A
L
A
R
L
A
V
E
H
D
F
Y
L
V
S
D
E
I
Y
E
H
L
L
Y
E
G
E
H
F
S
P
-
G
R
V
A
P
---
E
H
T
L
T
V
N
G
A
A
K
A
F
A
M
T
G
W
R
I
G
Y
A
C
G
P
K
E
V
I
K
A
M
A
S
V
S
R
Q
S
T
T
S
P
D
T
I
A
Q
W
A
T
L
E
A
L
T
N
Q
EAS
R
A
--
F
---
V
E
M
A
R
E
A
Y
R
R
R
R
D
L
L
L
E
G
L
T
A
L
-
G
L
K
A
V
R
P
S
G
A
F
Y
V
L
-------
M
D
T
S
P
I
A
P
D
E
-----
V
R
A
A
E
R
L
-
L
E
A
G
V
A
V
V
P
G
T
D
F
A
A
--
F
G
H
--
V
R
L
S
Y
A
T
S
E
E
N
L
R
K
A
L
E
R
F
A
R
V
L
-----
35
PsiBlast_CBE
77.80
38%
-66
- C1 -
-
1GC3
4
AAT_THET8
E:
[4-382]
--
L
S
R
R
V
Q
A
M
K
P
D
A
V
V
A
V
N
A
K
A
L
E
L
R
R
Q
G
V
D
L
V
A
L
T
A
G
E
P
D
F
D
T
P
E
H
V
K
E
A
A
R
R
A
L
A
Q
G
K
T
K
-
Y
A
P
P
A
G
I
P
E
L
R
E
A
L
A
E
K
F
R
R
E
N
G
L
S
V
-
T
P
-
E
E
T
I
V
T
V
G
G
S
Q
A
L
F
N
L
F
Q
A
I
L
D
P
G
D
E
V
I
V
L
S
P
Y
W
V
S
Y
P
E
M
V
R
F
A
G
G
V
V
V
E
V
E
T
L
P
E
E
G
F
V
P
D
P
E
R
V
R
R
A
I
T
P
R
T
K
A
L
V
V
N
S
P
N
N
P
T
G
A
V
Y
P
K
E
V
L
E
A
L
A
R
L
A
V
E
H
D
F
Y
L
V
S
D
E
I
Y
E
H
L
L
Y
E
G
E
H
F
S
P
G
R
V
A
P
E
----
H
T
L
T
V
N
G
A
A
K
A
F
A
M
T
G
W
R
I
G
Y
A
C
G
P
K
E
V
I
K
A
M
A
S
V
S
R
Q
S
T
T
S
P
D
T
I
A
Q
W
A
T
L
E
A
L
T
N
Q
---
E
A
--
S
RAF
V
E
M
A
R
E
A
Y
R
R
R
R
D
L
L
L
E
G
L
T
A
L
-
G
L
K
A
V
R
P
S
G
A
F
Y
V
L
MDTSPIA
P
D
E
V
R
A
A
E
R
-------------
L
L
E
A
G
V
A
V
V
P
G
T
D
F
A
A
--
F
G
H
--
V
R
L
S
Y
A
T
S
E
E
N
L
R
K
A
L
E
R
F
A
R
V
L
-----
61
HHSearch
77.70
39%
-65
- C1 -
-
1BJW
-
AAT_THET8
B:
[3-381]
-
G
L
S
R
R
V
Q
A
M
K
P
S
A
T
V
A
V
N
A
K
A
L
E
L
R
R
Q
G
V
D
L
V
A
L
T
A
G
E
P
D
F
D
T
P
E
H
V
K
E
A
A
R
R
A
L
A
-
Q
G
K
T
K
Y
A
P
P
A
G
I
P
E
L
R
E
A
L
A
E
K
F
R
R
E
N
G
L
S
V
-
T
P
-
E
E
T
I
V
T
V
G
G
K
Q
A
L
F
N
L
F
Q
A
I
L
D
P
G
D
E
V
I
V
L
S
P
Y
W
V
S
Y
P
E
M
V
R
F
A
G
G
V
V
V
E
V
E
T
L
P
E
E
G
F
V
P
D
P
E
R
V
R
R
A
I
T
P
R
T
K
A
L
V
V
N
S
P
N
N
P
T
G
A
V
Y
P
K
E
V
L
E
A
L
A
R
L
A
V
E
H
D
F
Y
L
V
S
D
E
I
Y
E
H
L
L
Y
E
G
E
H
-
F
S
P
G
R
V
A
P
---
E
H
T
L
T
V
N
G
A
A
K
A
F
A
M
T
G
W
R
I
G
Y
A
C
G
P
K
E
V
I
K
A
M
A
S
V
S
S
Q
S
T
T
S
P
D
T
I
A
Q
W
A
T
L
E
A
L
T
N
Q
EAS
R
A
--
F
---
V
E
M
A
R
E
A
Y
R
R
R
R
D
L
L
L
E
G
L
T
A
L
-
G
L
K
A
V
R
P
S
G
A
F
Y
V
L
-------
M
D
T
S
P
I
A
P
D
E
-----
V
R
A
A
E
R
L
-
L
E
A
G
V
A
V
V
P
G
T
D
F
A
A
--
F
G
H
--
V
R
L
S
Y
A
T
S
E
E
N
L
R
K
A
L
E
R
F
A
R
V
------
26
PsiBlast_CBE
77.70
38%
-59
- C1 -
-
1GCK
4
AAT_THET8
B:
[4-382]
--
L
S
R
R
V
Q
A
M
K
P
S
A
T
V
A
V
N
A
K
A
L
E
L
R
R
Q
G
V
D
L
V
A
L
T
A
G
E
P
D
F
D
T
P
E
H
V
K
E
A
A
R
R
A
L
A
Q
G
K
T
K
-
Y
A
P
P
A
G
I
P
E
L
R
E
A
L
A
E
K
F
R
R
E
N
G
L
S
V
-
T
P
-
E
E
T
I
V
T
V
G
G
S
Q
A
L
F
N
L
F
Q
A
I
L
D
P
G
D
E
V
I
V
L
S
P
Y
W
V
S
Y
P
E
M
V
R
F
A
G
G
V
V
V
E
V
E
T
L
P
E
E
G
F
V
P
D
P
E
R
V
R
R
A
I
T
P
R
T
K
A
L
V
V
N
S
P
N
N
P
T
G
A
V
Y
P
K
E
V
L
E
A
L
A
R
L
A
V
E
H
D
F
Y
L
V
S
D
E
I
Y
E
H
L
L
Y
E
G
E
H
F
S
P
G
R
V
A
P
E
----
H
T
L
T
V
N
G
A
A
K
A
F
A
M
T
G
W
R
I
G
Y
A
C
G
P
K
E
V
I
K
A
M
A
S
V
S
R
Q
S
T
T
S
P
D
T
I
A
Q
W
A
T
L
E
A
L
T
N
Q
---
E
A
--
S
RAF
V
E
M
A
R
E
A
Y
R
R
R
R
D
L
L
L
E
G
L
T
A
L
-
G
L
K
A
V
R
P
S
G
A
F
Y
V
L
MDTSPIA
P
D
E
V
R
A
A
E
R
-------------
L
L
E
A
G
V
A
V
V
P
G
T
D
F
A
A
--
F
G
H
--
V
R
L
S
Y
A
T
S
E
E
N
L
R
K
A
L
E
R
F
A
R
V
L
-----
4
PsiBlast_PDB
76.67
38%
-62
- C1 -
-
1GCK
4
AAT_THET8
A:
[4-382]
--
L
S
R
R
V
Q
A
M
K
P
S
A
T
V
A
V
N
A
K
A
L
E
L
R
R
Q
G
V
D
L
V
A
L
T
A
G
E
P
D
F
D
T
P
E
H
V
K
E
A
A
R
R
A
L
A
Q
G
K
T
K
-
Y
A
P
P
A
G
I
P
E
L
R
E
A
L
A
E
K
F
R
R
E
N
G
L
S
V
-
T
P
-
E
E
T
I
V
T
V
G
G
S
Q
A
L
F
N
L
F
Q
A
I
L
D
P
G
D
E
V
I
V
L
S
P
Y
W
V
S
Y
P
E
M
V
R
F
A
G
G
V
V
V
E
V
E
T
L
P
E
E
G
F
V
P
D
P
E
R
V
R
R
A
I
T
P
R
T
K
A
L
V
V
N
S
P
N
N
P
T
G
A
V
Y
P
K
E
V
L
E
A
L
A
R
L
A
V
E
H
D
F
Y
L
V
S
D
E
I
Y
E
H
L
L
Y
E
G
E
H
F
S
P
G
R
V
A
P
E
----
H
T
L
T
V
N
G
A
A
K
A
F
A
M
T
G
W
R
I
G
Y
A
C
G
P
K
E
V
I
K
A
M
A
S
V
S
R
Q
S
T
T
S
P
D
T
I
A
Q
W
A
T
L
E
A
L
T
N
Q
---
E
A
--
S
R
A
F
V
E
M
A
R
E
A
Y
R
R
R
R
D
L
L
L
E
G
L
T
A
L
-
G
L
K
A
V
R
P
S
G
A
F
Y
V
L
M
D
TSPIA
P
D
E
V
R
A
A
E
R
-------------
L
L
E
A
G
V
A
V
V
P
G
T
D
F
A
A
--
F
G
H
--
V
R
L
S
Y
A
T
S
E
E
N
L
R
K
A
L
E
R
F
A
R
V
L
-----
13
PsiBlast_PDB
75.76
35%
-40
- C1 -
-
1GDE
4
?
A:
[2-380]
-
A
L
S
D
R
L
----
E
L
V
S
A
S
E
I
R
K
L
F
D
I
A
A
G
M
K
D
V
I
S
L
G
I
G
E
P
D
F
D
T
P
Q
H
I
K
E
Y
A
K
E
A
L
D
K
G
-
L
T
H
Y
G
P
N
I
G
L
L
E
L
R
E
A
I
A
E
K
L
K
K
Q
N
G
I
E
A
D
P
K
-
T
E
I
M
V
L
L
G
A
N
Q
A
F
L
M
G
L
S
A
F
L
K
D
G
E
E
V
L
I
P
T
P
A
F
V
S
Y
A
P
A
V
I
L
A
G
G
K
P
V
E
V
P
T
Y
E
E
D
E
F
R
L
N
V
D
E
L
K
K
Y
V
T
D
K
T
R
A
L
I
I
N
S
P
C
N
P
T
G
A
V
L
T
K
K
D
L
E
E
I
A
D
F
V
V
E
H
D
L
I
V
I
S
D
E
V
Y
E
H
F
I
Y
D
D
A
R
H
Y
S
I
A
S
L
-
D
G
M
F
E
R
T
I
T
V
N
G
F
S
K
T
F
A
M
T
G
W
R
L
G
F
V
A
A
P
S
W
I
I
E
R
M
V
K
F
Q
M
Y
N
A
T
C
P
V
T
F
I
Q
Y
A
A
A
K
A
L
K
D
E
---
R
S
W
K
A
---
V
E
E
M
R
K
E
Y
D
R
R
R
K
L
V
W
K
R
L
N
E
M
-
G
L
P
T
V
K
P
K
G
A
F
Y
I
F
-------
P
R
I
R
D
T
----
G
L
T
S
-
K
K
F
S
E
L
M
L
K
E
A
R
V
A
V
V
P
G
S
A
F
G
K
--
A
G
E
G
Y
V
R
I
S
Y
A
T
A
Y
E
K
L
E
E
A
M
D
R
M
E
--------
62
HHSearch
74.70
35%
-38
- C1 -
-
1GDE
4
?
A:
[2-387]
-
A
L
S
D
R
L
E
L
V
S
A
S
E
I
R
K
L
F
----
D
I
A
A
G
M
K
D
V
I
S
L
G
I
G
E
P
D
F
D
T
P
Q
H
I
K
E
Y
A
K
E
A
L
D
-
K
G
L
T
H
Y
G
P
N
I
G
L
L
E
L
R
E
A
I
A
E
K
L
K
K
Q
N
G
I
E
A
-
D
P
K
T
E
I
M
V
L
L
G
A
N
Q
A
F
L
M
G
L
S
A
F
L
K
D
G
E
E
V
L
I
P
T
P
A
F
V
S
Y
A
P
A
V
I
L
A
G
G
K
P
V
E
V
P
T
Y
E
E
D
E
F
R
L
N
V
D
E
L
K
K
Y
V
T
D
K
T
R
A
L
I
I
N
S
P
C
N
P
T
G
A
V
L
T
K
K
D
L
E
E
I
A
D
F
V
V
E
H
D
L
I
V
I
S
D
E
V
Y
E
H
F
I
Y
D
D
A
R
H
Y
S
I
A
S
L
D
G
-
M
F
E
R
T
I
T
V
N
G
F
S
K
T
F
A
M
T
G
W
R
L
G
F
V
A
A
P
S
W
I
I
E
R
M
V
K
F
Q
M
Y
N
A
T
C
P
V
T
F
I
Q
Y
A
A
A
K
A
L
K
D
E
R
S
-
W
K
--
A
---
V
E
E
M
R
K
E
Y
D
R
R
R
K
L
V
W
K
R
L
N
E
M
-
G
L
P
T
V
K
P
K
G
A
F
Y
I
F
-------
P
R
I
R
D
T
G
L
T
S
-----
K
K
F
S
E
L
M
L
K
E
A
R
V
A
V
V
P
G
S
A
F
G
K
AG
E
G
Y
--
V
R
I
S
Y
A
T
A
Y
E
K
L
E
E
A
M
D
R
M
E
R
V
L
K
E
R
K
-
14
PsiBlast_PDB
73.89
35%
-39
- C1 -
-
1GD9
2
?
A:
[2-380]
-
A
L
S
D
R
L
----
E
L
V
S
A
S
E
I
R
K
L
F
D
I
A
A
G
M
K
D
V
I
S
L
G
I
G
E
P
D
F
D
T
P
Q
H
I
K
E
Y
A
K
E
A
L
D
K
G
-
L
T
H
Y
G
P
N
I
G
L
L
E
L
R
E
A
I
A
E
K
L
K
K
Q
N
G
I
E
A
D
P
K
-
T
E
I
M
V
L
L
G
A
N
Q
A
F
L
M
G
L
S
A
F
L
K
D
G
E
E
V
L
I
P
T
P
A
F
V
S
Y
A
P
A
V
I
L
A
G
G
K
P
V
E
V
P
T
Y
E
E
D
E
F
R
L
N
V
D
E
L
K
K
Y
V
T
D
K
T
R
A
L
I
I
N
S
P
C
N
P
T
G
A
V
L
T
K
K
D
L
E
E
I
A
D
F
V
V
E
H
D
L
I
V
I
S
D
E
V
Y
E
H
F
I
Y
D
D
A
R
H
Y
S
I
A
S
L
-
D
G
M
F
E
R
T
I
T
V
N
G
F
S
K
T
F
A
M
T
G
W
R
L
G
F
V
A
A
P
S
W
I
I
E
R
M
V
K
F
Q
M
Y
N
A
T
C
P
V
T
F
I
Q
Y
A
A
A
K
A
L
K
D
E
---
R
S
W
K
A
---
V
E
E
M
R
K
E
Y
D
R
R
R
K
L
V
W
K
R
L
N
E
M
-
G
L
P
T
V
K
P
K
G
A
F
Y
I
F
-------
P
R
I
R
D
T
----
G
L
T
S
-
K
K
F
S
E
L
M
L
K
E
A
R
V
A
V
V
P
G
S
A
F
G
K
--
A
G
E
G
Y
V
R
I
S
Y
A
T
A
Y
E
K
L
E
E
A
M
D
R
M
E
--------
28
PsiBlast_CBE
73.09
38%
-61
- C1 -
-
5BJ4
2
AAT_THET8
B:
[4-382]
--
L
S
R
R
V
Q
A
M
K
P
----------------
G
V
D
L
V
A
L
T
A
G
E
P
D
F
D
T
P
E
H
V
K
E
A
A
R
R
A
L
A
Q
G
K
T
K
-
Y
A
P
P
A
G
I
P
E
L
R
E
A
L
A
E
K
F
R
R
E
N
G
L
S
V
-
T
P
-
E
E
T
I
V
T
V
G
G
S
Q
A
L
F
N
L
F
Q
A
I
L
D
P
G
D
E
V
I
V
L
S
P
Y
W
V
S
Y
P
E
M
V
R
F
A
G
G
V
V
V
E
V
E
T
L
P
E
E
G
F
V
P
D
P
E
R
V
R
R
A
I
T
P
R
T
K
A
L
V
V
N
S
P
N
N
P
T
G
A
V
Y
P
K
E
V
L
E
A
L
A
R
L
A
V
E
H
D
F
Y
L
V
S
D
E
I
Y
E
H
L
L
Y
E
G
E
H
F
S
P
G
R
V
A
P
E
----
H
T
L
T
V
N
G
A
A
K
A
F
A
M
T
G
W
R
I
G
Y
A
C
G
P
K
E
V
I
K
A
M
A
S
V
S
R
Q
S
T
T
S
P
D
T
I
A
Q
W
A
T
L
E
A
L
T
N
Q
---
E
A
--
S
RAF
V
E
M
A
R
E
A
Y
R
R
R
R
D
L
L
L
E
G
L
T
A
L
-
G
L
K
A
V
R
P
S
G
A
F
Y
V
L
MDTSPIA
P
D
E
V
R
A
A
E
R
-------------
L
L
E
A
G
V
A
V
V
P
G
T
D
F
A
A
--
F
G
H
--
V
R
L
S
Y
A
T
S
E
E
N
L
R
K
A
L
E
R
F
A
R
V
L
-----
44
PsiBlast_CBE
73.05
35%
-39
- C1 -
-
1GDE
4
?
B:
[2-380]
-
A
L
S
D
R
L
----
E
L
V
S
A
S
E
I
R
K
L
F
D
I
A
A
G
M
K
D
V
I
S
L
G
I
G
E
P
D
F
D
T
P
Q
H
I
K
E
Y
A
K
E
A
L
D
K
G
-
L
T
H
Y
G
P
N
I
G
L
L
E
L
R
E
A
I
A
E
K
L
K
K
Q
N
G
I
E
A
D
P
K
-
T
E
I
M
V
L
L
G
A
N
Q
A
F
L
M
G
L
S
A
F
L
K
D
G
E
E
V
L
I
P
T
P
A
F
V
S
Y
A
P
A
V
I
L
A
G
G
K
P
V
E
V
P
T
Y
E
E
D
E
F
R
L
N
V
D
E
L
K
K
Y
V
T
D
K
T
R
A
L
I
I
N
S
P
C
N
P
T
G
A
V
L
T
K
K
D
L
E
E
I
A
D
F
V
V
E
H
D
L
I
V
I
S
D
E
V
Y
E
H
F
I
Y
D
D
A
R
H
Y
S
I
A
S
L
-
D
G
M
F
E
R
T
I
T
V
N
G
F
S
K
T
F
A
M
T
G
W
R
L
G
F
V
A
A
P
S
W
I
I
E
R
M
V
K
F
Q
M
Y
N
A
T
C
P
V
T
F
I
Q
Y
A
A
A
K
A
L
K
D
E
---
R
S
WK
A
---
V
E
E
M
R
K
E
Y
D
R
R
R
K
L
V
W
K
R
L
N
E
M
-
G
L
P
T
V
K
P
K
G
A
F
Y
I
F
-------
P
R
I
R
D
T
----
G
L
T
S
-
K
K
F
S
E
L
M
L
K
E
A
R
V
A
V
V
P
G
S
A
F
G
K
--
A
G
E
GY
V
R
I
S
Y
A
T
A
Y
E
K
L
E
E
A
M
D
R
M
E
--------
9
PsiBlast_PDB
72.61
38%
-62
- C1 -
-
5BJ4
2
AAT_THET8
A:
[4-382]
--
L
S
R
R
V
Q
A
M
K
P
----------------
G
V
D
L
V
A
L
T
A
G
E
P
D
F
D
T
P
E
H
V
K
E
A
A
R
R
A
L
A
Q
G
K
T
K
-
Y
A
P
P
A
G
I
P
E
L
R
E
A
L
A
E
K
F
R
R
E
N
G
L
S
V
-
T
P
-
E
E
T
I
V
T
V
G
G
S
Q
A
L
F
N
L
F
Q
A
I
L
D
P
G
D
E
V
I
V
L
S
P
Y
W
V
S
Y
P
E
M
V
R
F
A
G
G
V
V
V
E
V
E
T
L
P
E
E
G
F
V
P
D
P
E
R
V
R
R
A
I
T
P
R
T
K
A
L
V
V
N
S
P
N
N
P
T
G
A
V
Y
P
K
E
V
L
E
A
L
A
R
L
A
V
E
H
D
F
Y
L
V
S
D
E
I
Y
E
H
L
L
Y
E
G
E
H
F
S
P
G
R
V
A
P
E
----
H
T
L
T
V
N
G
A
A
K
A
F
A
M
T
G
W
R
I
G
Y
A
C
G
P
K
E
V
I
K
A
M
A
S
V
S
R
Q
S
T
T
S
P
D
T
I
A
Q
W
A
T
L
E
A
L
T
N
Q
---
E
A
--
S
R
A
F
V
E
M
A
R
E
A
Y
R
R
R
R
D
L
L
L
E
G
L
T
A
L
-
G
L
K
A
V
R
P
S
G
A
F
Y
V
L
M
D
TSPIA
P
D
E
V
R
A
A
E
R
-------------
L
L
E
A
G
V
A
V
V
P
G
T
D
F
A
A
--
F
G
H
--
V
R
L
S
Y
A
T
S
E
E
N
L
R
K
A
L
E
R
F
A
R
V
L
-----
45
PsiBlast_CBE
71.60
35%
-39
- C1 -
-
1GD9
2
?
B:
[2-380]
-
A
L
S
D
R
L
----
E
L
V
S
A
S
E
I
R
K
L
F
D
I
A
A
G
M
K
D
V
I
S
L
G
I
G
E
P
D
F
D
T
P
Q
H
I
K
E
Y
A
K
E
A
L
D
K
G
-
L
T
H
Y
G
P
N
I
G
L
L
E
L
R
E
A
I
A
E
K
L
K
K
Q
N
G
I
E
A
D
P
K
-
T
E
I
M
V
L
L
G
A
N
Q
A
F
L
M
G
L
S
A
F
L
K
D
G
E
E
V
L
I
P
T
P
A
F
V
S
Y
A
P
A
V
I
L
A
G
G
K
P
V
E
V
P
T
Y
E
E
D
E
F
R
L
N
V
D
E
L
K
K
Y
V
T
D
K
T
R
A
L
I
I
N
S
P
C
N
P
T
G
A
V
L
T
K
K
D
L
E
E
I
A
D
F
V
V
E
H
D
L
I
V
I
S
D
E
V
Y
E
H
F
I
Y
D
D
A
R
H
Y
S
I
A
S
L
-
D
G
M
F
E
R
T
I
T
V
N
G
F
S
K
T
F
A
M
T
G
W
R
L
G
F
V
A
A
P
S
W
I
I
E
R
M
V
K
F
Q
M
Y
N
A
T
C
P
V
T
F
I
Q
Y
A
A
A
K
A
L
K
D
E
---
R
S
WK
A
---
V
E
E
M
R
K
E
Y
D
R
R
R
K
L
V
W
K
R
L
N
E
M
-
G
L
P
T
V
K
P
K
G
A
F
Y
I
F
-------
P
R
I
R
D
T
----
G
L
T
S
-
K
K
F
S
E
L
M
L
K
E
A
R
V
A
V
V
P
G
S
A
F
G
K
--
A
G
E
GY
V
R
I
S
Y
A
T
A
Y
E
K
L
E
E
A
M
D
R
M
E
--------
12
PsiBlast_PDB
66.65
36%
-41
- C1 -
-
1DJU
2
?
A:
[25-379]
-----------------------------
K
D
V
I
S
L
G
I
G
E
P
D
F
D
T
P
Q
H
I
K
E
Y
A
K
E
A
L
D
K
G
-
L
T
H
Y
G
P
N
I
G
L
L
E
L
R
E
A
I
A
E
K
L
K
K
Q
N
G
I
E
A
D
P
K
-
T
E
I
M
V
L
L
G
A
N
Q
A
F
L
M
G
L
S
A
F
L
K
D
G
E
E
V
L
I
P
T
P
A
F
V
S
Y
A
P
A
V
I
L
A
G
G
K
P
V
E
V
P
T
Y
E
E
D
E
F
R
L
N
V
D
E
L
K
K
Y
V
T
D
K
T
R
A
L
I
I
N
S
P
C
N
P
T
G
A
V
L
T
K
K
D
L
E
E
I
A
D
F
V
V
E
H
D
L
I
V
I
S
D
E
V
Y
E
H
F
I
Y
D
D
A
R
H
Y
S
I
A
S
L
-
D
G
M
F
E
R
T
I
T
V
N
G
F
S
K
T
F
A
M
T
G
W
R
L
G
F
V
A
A
P
S
W
I
I
E
R
M
V
K
F
Q
M
Y
N
A
T
C
P
V
T
F
I
Q
Y
A
A
A
K
A
L
K
D
E
---
R
S
W
K
A
---
V
E
E
M
R
K
E
Y
D
R
R
R
K
L
V
W
K
R
L
N
E
M
-
G
L
P
T
V
K
P
K
G
A
F
Y
I
F
-------
P
R
I
R
D
T
----
G
L
T
S
-
K
K
F
S
E
L
M
L
K
E
A
R
V
A
V
V
P
G
S
A
F
G
K
--
A
G
E
G
Y
V
R
I
S
Y
A
T
A
Y
E
K
L
E
E
A
M
E
R
M
E
--------