@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : spr1421: (2018-01-11 )
MSQLYDITIVGGGPVGLFAAFYAHLRQAKVQIIDSLPQLGGQPAILYPEKEILDVPGFPNLTGEELTNRLIEQLNGFDTPIHLNETVLEIDKQEEEFAITTSKGSHLTKTVIIAMGGGAFKPRPLELEGVEDYENIHYHVSNIQQYAGKKVTILGGGDSAVDWALAFEKIAPTTLVHRRDNFRALEHSVQALQESSVTIKTPFAPSQLLGDGKTLDKLEITKVKSDETETIDLDHLFVNYGFKSSVGNLKNWGLDLNRHKIIVNSKQESSQAGIYAIGDCCYYDGKIDLIATGLGEAPTAVNNAINYIDPEQKVQPKHSTSL
Atome Classification :
(20 SA)
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------.........10........20........30...-.....40........50......-.-.-60........70........80---........90--...---.-.-.-...-100.-...-...-.110.......120....-...130.---.--...-.-.140...---....150.......160.......-170.-.-.-.....180..----.----.-...190.----..-..-...200.......210.......220.......-230.......240.......250.....-..-260...-----..-----.-----.270.......280.......290.......300.......310.......320
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MS
Q
L
Y
D
I
T
I
VGGG
P
V
G
L
F
A
A
F
Y
A
H
L
R
Q
A
K
V
Q
I
I
D
-
S
L
P
QLGGQ
P
A
I
LYP
E
K
E
ILDVPG-F-P-NL
T
G
E
E
L
T
N
R
L
I
E
Q
LNGFDTPI---HLN
E
T
V
L
EI---DKQ---E-E-
E
-
F
A
I
-TT-S-KGS-
H
L
T
-
K
T
V
I
I
A
MGGGAFKPRPLE-LEGVED
Y
---
E
--
N
I
H
-
Y
-
H
V
S
N
I
Q
Q
---YAG
K
K
V
T
I
LGGGD
S
A
V
D
W
A
L
A
F
E
K-IA-P-T-
T
-
L
V
HRRD
N
F
R
A
----
L
----
E
-
H
S
V
Q
-
A
L
----
Q
E-SS-
V
T
I
KTPFA
P
S
Q
LLGDGKTL
D
K
L
E
I
T
KVKSDET
E
-
T
I
D
LD
H
L
F
VNYGFKSSVGNLKNWGLDLN-
R
H
-
K
I
I
V
NS-----KQ-----E-----SSQA
G
I
Y
A
IG
D
C
C
Y
YDG
K
I
D
L
I
ATGLGEA
P
T
A
V
NNAINYIDPEQKVQPKHSTSL
50
HHSearch
84.89
56%
-22
- C1 -
-
3LZX
3
FENR2_BACSU
B:
[5-328]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
K
V
Y
D
I
T
I
I
G
G
G
P
V
G
L
F
T
A
F
Y
G
G
M
R
Q
A
S
V
K
I
I
E
-
S
L
P
Q
L
G
G
Q
L
S
A
L
Y
P
E
K
Y
I
Y
D
V
A
G
-
F
-
P
-
K
I
R
A
Q
E
L
I
N
N
L
K
E
Q
M
A
K
F
D
Q
T
I
---
C
L
E
Q
A
V
E
S
V
---
E
K
Q
---
A
D
G
-
V
-
F
K
L
-
V
T
-
N
-
E
E
T
-
H
Y
S
-
K
T
V
I
I
T
A
G
N
G
A
F
K
P
R
K
L
E
-
L
E
N
A
E
Q
Y
---
E
GK
N
L
H
-
Y
-
F
V
D
D
L
Q
K
---
F
A
G
R
R
V
A
I
L
G
G
G
D
S
A
V
D
W
A
L
M
L
E
P
-
I
A
-
K
E
V
-
S
-
I
I
H
R
R
D
K
F
R
A
----
H
----
E
-
H
S
V
E
-
N
L
----
H
A
-
S
K
-
V
N
V
L
T
P
F
V
P
A
E
L
I
G
E
-
D
K
I
E
Q
L
V
L
E
E
V
K
G
D
R
K
E
-
I
L
E
I
D
D
L
I
V
N
Y
G
F
V
S
S
L
G
P
I
K
N
W
G
L
D
I
E
-
K
N
-
S
I
V
V
K
S
-----
T
M
-----
E
-----
T
N
I
E
G
F
F
A
A
G
D
I
C
T
Y
E
G
K
V
N
L
I
A
S
G
F
G
E
A
P
T
A
V
N
N
A
K
A
Y
M
D
P
K
A
R
V
Q
P
L
H
S
T
S
L
21
PsiBlast_CBE
84.80
55%
-22
- C1 -
-
3LZX
3
FENR2_BACSU
B:
[5-328]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
K
V
Y
D
I
T
I
I
G
G
G
P
V
G
L
F
T
A
F
Y
G
G
M
R
Q
A
S
V
K
I
I
E
-
S
L
P
Q
L
G
G
Q
L
S
A
L
Y
P
E
K
Y
I
Y
D
V
A
G
-
F
-
P
-
K
I
R
A
Q
E
L
I
N
N
L
K
E
Q
M
A
K
F
D
Q
T
I
---
C
L
E
Q
A
V
E
S
V
---
E
K
Q
---
A
-
D
-
G
V
F
K
L
-
V
T
-
N
-
E
E
T
-
H
Y
S
-
K
T
V
I
I
T
A
G
N
G
A
F
K
P
R
K
L
E
-
L
E
N
A
E
Q
Y
---
E
GK
N
L
H
-
Y
-
F
V
D
D
L
Q
K
---
F
A
G
R
R
V
A
I
L
G
G
G
D
S
A
V
D
W
A
L
M
L
E
P
-
I
A
-
K
E
V
-
S
-
I
I
H
R
R
D
K
F
R
A
----
H
----
E
-
H
S
V
E
-
N
L
----
H
A
-
S
K
-
V
N
V
L
T
P
F
V
P
A
E
L
I
G
E
D
K
-
I
E
Q
L
V
L
E
E
V
K
G
D
R
K
E
-
I
L
E
I
D
D
L
I
V
N
Y
G
F
V
S
S
L
G
P
I
K
N
W
G
L
D
I
E
-
K
N
-
S
I
V
V
K
S
-----
T
M
-----
E
-----
T
N
I
E
G
F
F
A
A
G
D
I
C
T
Y
E
G
K
V
N
L
I
A
S
G
F
G
E
A
P
T
A
V
N
N
A
K
A
Y
M
D
P
K
A
R
V
Q
P
L
H
S
T
S
L
1
PsiBlast_PDB
83.52
55%
-25
- C1 -
-
3LZW
2
FENR2_BACSU
A:
[5-328]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
K
V
Y
D
I
T
I
I
G
G
G
P
V
G
L
F
T
A
F
Y
G
G
M
R
Q
A
S
V
K
I
I
E
-
S
L
P
Q
L
G
G
Q
L
S
A
L
Y
P
E
K
Y
I
Y
D
V
A
G
-
F
-
P
-
K
I
R
A
Q
E
L
I
N
N
L
K
E
Q
M
A
K
F
D
Q
T
I
---
C
L
E
Q
A
V
E
S
V
---
E
K
Q
---
A
-
D
-
G
V
F
K
L
-
V
T
-
N
-
E
E
T
-
H
Y
S
-
K
T
V
I
I
T
A
G
N
G
A
F
K
P
R
K
L
E
-
L
E
N
A
E
Q
Y
---
E
GK
N
L
H
-
Y
-
F
V
D
D
L
Q
K
---
F
A
G
R
R
V
A
I
L
G
G
G
D
S
A
V
D
W
A
L
M
L
E
P
-
I
A
-
K
E
V
-
S
-
I
I
H
R
R
D
K
F
R
A
----
H
----
E
-
H
S
V
E
-
N
L
----
H
A
-
S
K
-
V
N
V
L
T
P
F
V
P
A
E
L
I
G
E
D
K
-
I
E
Q
L
V
L
E
E
V
K
G
D
R
K
E
-
I
L
E
I
D
D
L
I
V
N
Y
G
F
V
S
S
L
G
P
I
K
N
W
G
L
D
I
E
-
K
N
-
S
I
V
V
K
S
-----
T
M
-----
E
-----
T
N
I
E
G
F
F
A
A
G
D
I
C
T
Y
E
G
K
V
N
L
I
A
S
G
F
G
E
A
P
T
A
V
N
N
A
K
A
Y
M
D
P
K
A
R
V
Q
P
L
H
S
T
S
L
49
HHSearch
83.30
56%
-25
- C1 -
-
3LZW
2
FENR2_BACSU
A:
[5-328]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
K
V
Y
D
I
T
I
I
G
G
G
P
V
G
L
F
T
A
F
Y
G
G
M
R
Q
A
S
V
K
I
I
E
-
S
L
P
Q
L
G
G
Q
L
S
A
L
Y
P
E
K
Y
I
Y
D
V
A
G
-
F
-
P
-
K
I
R
A
Q
E
L
I
N
N
L
K
E
Q
M
A
K
F
D
Q
T
I
---
C
L
E
Q
A
V
E
S
V
---
E
K
Q
---
A
D
G
-
V
-
F
K
L
-
V
T
-
N
-
E
E
T
-
H
Y
S
-
K
T
V
I
I
T
A
G
N
G
A
F
K
P
R
K
L
E
-
L
E
N
A
E
Q
Y
---
E
GK
N
L
H
-
Y
-
F
V
D
D
L
Q
K
---
F
A
G
R
R
V
A
I
L
G
G
G
D
S
A
V
D
W
A
L
M
L
E
P
-
I
A
-
K
E
V
-
S
-
I
I
H
R
R
D
K
F
R
A
----
H
----
E
-
H
S
V
E
-
N
L
----
H
A
-
S
K
-
V
N
V
L
T
P
F
V
P
A
E
L
I
G
E
-
D
K
I
E
Q
L
V
L
E
E
V
K
G
D
R
K
E
-
I
L
E
I
D
D
L
I
V
N
Y
G
F
V
S
S
L
G
P
I
K
N
W
G
L
D
I
E
-
K
N
-
S
I
V
V
K
S
-----
T
M
-----
E
-----
T
N
I
E
G
F
F
A
A
G
D
I
C
T
Y
E
G
K
V
N
L
I
A
S
G
F
G
E
A
P
T
A
V
N
N
A
K
A
Y
M
D
P
K
A
R
V
Q
P
L
H
S
T
S
L
2
PsiBlast_PDB
83.30
55%
-21
- C1 -
-
3LZX
3
FENR2_BACSU
A:
[5-328]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
K
V
Y
D
I
T
I
I
G
G
G
P
V
G
L
F
T
A
F
Y
G
G
M
R
Q
A
S
V
K
I
I
E
-
S
L
P
Q
L
G
G
Q
L
S
A
L
Y
P
E
K
Y
I
Y
D
V
A
G
-
F
-
P
-
K
I
R
A
Q
E
L
I
N
N
L
K
E
Q
M
A
K
F
D
Q
T
I
---
C
L
E
Q
A
V
E
S
V
---
E
K
Q
---
A
-
D
-
G
V
F
K
L
-
V
T
-
N
-
E
E
T
-
H
Y
S
-
K
T
V
I
I
T
A
G
N
G
A
F
K
P
R
K
L
E
-
L
E
N
A
E
Q
Y
---
E
GK
N
L
H
-
Y
-
F
V
D
D
L
Q
K
---
F
A
G
R
R
V
A
I
L
G
G
G
D
S
A
V
D
W
A
L
M
L
E
P
-
I
A
-
K
E
V
-
S
-
I
I
H
R
R
D
K
F
R
A
----
H
----
E
-
H
S
V
E
-
N
L
----
H
A
-
S
K
-
V
N
V
L
T
P
F
V
P
A
E
L
I
G
E
D
K
-
I
E
Q
L
V
L
E
E
V
K
G
D
R
K
E
-
I
L
E
I
D
D
L
I
V
N
Y
G
F
V
S
S
L
G
P
I
K
N
W
G
L
D
I
E
-
K
N
-
S
I
V
V
K
S
-----
T
M
-----
E
-----
T
N
I
E
G
F
F
A
A
G
D
I
C
T
Y
E
G
K
V
N
L
I
A
S
G
F
G
E
A
P
T
A
V
N
N
A
K
A
Y
M
D
P
K
A
R
V
Q
P
L
H
S
T
S
L
3
PsiBlast_PDB
70.09
39%
-17
- C1 -
-
2ZBW
2
FENR_THET8
A:
[7-328]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
V
L
I
V
G
A
G
P
T
G
L
F
A
G
F
Y
V
G
M
R
G
L
S
F
R
F
V
D
-
P
L
P
E
P
G
G
Q
L
T
A
L
Y
P
E
K
Y
I
Y
D
V
A
G
-
F
-
P
-
K
V
Y
A
K
D
L
V
K
G
L
V
E
Q
V
A
P
F
N
P
V
Y
---
S
L
G
E
R
A
E
T
L
---
E
R
E
---
G
-
D
-
L
-
F
K
V
-
T
T
-
S
-
Q
G
N
-
A
Y
T
A
K
A
V
I
I
A
A
G
V
G
A
F
E
P
R
R
I
G
-
A
P
G
E
R
E
F
---
E
GR
G
V
Y
-
Y
-
A
V
K
S
K
A
E
---
F
Q
G
K
R
V
L
I
V
G
G
G
D
S
A
V
D
W
A
L
N
L
L
D
-
T
A
-
R
-
R
I
T
-
L
I
H
R
R
P
Q
F
R
A
----
H
----
E
-
A
S
V
K
-
E
L
M
K
A
H
E
E
-
G
R
-
L
E
V
L
T
P
Y
E
L
R
R
V
E
G
D
E
R
V
R
W
A
V
-
V
F
H
N
Q
T
Q
E
E
L
-
A
L
E
V
D
A
V
L
I
L
A
G
Y
I
T
K
L
G
P
L
A
N
W
G
L
A
L
E
-
K
N
-
K
I
K
V
D
T
-----
T
M
-----
A
-----
T
S
I
P
G
V
Y
A
C
G
D
I
V
T
Y
P
G
K
L
P
L
I
V
L
G
F
G
E
A
A
I
A
A
N
H
A
A
A
Y
A
N
P
A
L
K
V
N
P
G
H
S
S
--
52
HHSearch
67.99
37%
-17
- C1 -
-
3AB1
1
FENR_CHLTE
A:
[13-330]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
M
R
D
L
T
I
I
G
G
G
P
T
G
I
F
A
A
F
Q
C
G
M
N
N
I
S
C
R
I
I
E
-
S
M
P
Q
L
G
G
Q
L
A
A
L
Y
P
E
K
H
I
Y
D
V
A
G
-
F
-
P
-
E
V
P
A
I
D
L
V
E
S
L
W
A
Q
A
E
R
Y
N
P
D
V
---
V
L
N
E
T
V
T
K
Y
---
T
K
L
D--
D
-
G
-
T
-
F
E
T
-
R
T
-
N
T
G
N
V
-
Y
R
S
-
R
A
V
L
I
A
A
G
L
G
A
F
E
P
R
K
L
P
Q
L
G
N
I
D
H
L
---
T
GS
S
V
Y
-
Y
-
A
V
K
S
V
E
D
---
F
K
G
K
R
V
V
I
V
G
G
G
D
S
A
L
D
W
T
V
G
L
I
K
-
N
A
-
A
S
V
-
T
-
L
V
H
R
G
H
E
F
Q
G
----
H
G
K
T
A
H
-
E
V
E
R
-
A
R
----
A
N
-
G
T
-
I
D
V
Y
L
E
T
E
V
A
S
I
E
E
S
N
G
V
L
T
R
V
H
L
R
S
S
-
D
G
S
K
W
-
T
V
E
A
D
R
L
L
I
L
I
G
F
K
S
N
L
G
P
L
A
R
W
D
L
E
L
Y
-
E
N
-
A
L
V
V
D
S
-----
H
M
-----
K
-----
T
S
V
D
G
L
Y
A
A
G
D
I
A
Y
Y
P
G
K
L
K
I
I
Q
T
G
L
S
E
A
T
M
A
V
R
H
S
L
S
Y
I
K
P
G
-----------
4
PsiBlast_PDB
66.07
37%
-22
- C1 -
-
3AB1
1
FENR_CHLTE
A:
[14-330]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
R
D
L
T
I
I
G
G
G
P
T
G
I
F
A
A
F
Q
C
G
M
N
N
I
S
C
R
I
I
E
-
S
M
P
Q
L
G
G
Q
L
A
A
L
Y
P
E
K
H
I
Y
D
V
A
G
-
F
-
P
-
E
V
P
A
I
D
L
V
E
S
L
W
A
Q
A
E
R
Y
N
P
D
V
---
V
L
N
E
T
V
T
K
Y
---
T
K
L
---
D
-
D
G
T
-
F
E
T
-
R
T
-
N
-
T
G
N
V
Y
R
S
-
R
A
V
L
I
A
A
G
L
G
A
F
E
P
R
K
L
P
-
Q
L
G
N
I
D
H
LTG
S
--
S
V
Y
-
Y
-
A
V
K
S
V
E
D
---
F
K
G
K
R
V
V
I
V
G
G
G
D
S
A
L
D
W
T
V
G
L
I
K
N
A
A
-
S
-
V
-
T
-
L
V
H
R
G
H
E
F
Q
G
HG
K
-
T
----
A
-
H
E
V
E
R
A
R
----
A
N
-
G
T
-
I
D
V
Y
L
E
T
E
V
A
S
I
E
E
S
N
G
V
L
T
R
V
H
L
R
--
S
S
D
G
S
K
W
T
V
E
A
D
R
L
L
I
L
I
G
F
K
S
N
L
G
P
L
A
R
W
D
L
E
L
Y
-
E
N
-
A
L
V
V
D
S
-----
H
M
-----
K
-----
T
S
V
D
G
L
Y
A
A
G
D
I
A
Y
Y
P
G
K
L
K
I
I
Q
T
G
L
S
E
A
T
M
A
V
R
H
S
L
S
Y
I
K
P
G
-----------
51
HHSearch
65.96
39%
-12
- C1 -
-
2ZBW
2
FENR_THET8
B:
[3-329]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
D
H
T
D
V
L
I
V
G
A
G
P
T
G
L
F
A
G
F
Y
V
G
M
R
G
L
S
F
R
F
V
D
-
P
L
P
E
P
G
G
Q
L
T
A
L
Y
P
E
K
Y
I
Y
D
V
A
G
-
F
-
P
-
K
V
Y
A
K
D
L
V
K
G
L
V
E
Q
V
A
P
F
N
P
V
Y
---
S
L
G
E
R
A
E
T
L
---
E
R
E
---
G
-
D
-
L
-
F
K
V
-
T
T
S
Q
-
G
N
A
-
Y
T
A
-
K
A
V
I
I
A
A
G
V
G
A
F
E
P
R
R
I
G
-
A
P
G
E
R
E
F
---
E
GR
G
V
Y
-
Y
-
A
V
K
S
K
A
E
---
F
Q
G
K
R
V
L
I
V
G
G
G
D
S
A
V
D
W
A
L
N
L
L
D
-
T
A
-
R
R
I
-
T
-
L
I
H
R
R
P
Q
F
R
A
----
H
E
A
S
V
K
-
E
L
M
K
-
A
H
----
E
E
-
G
R
-
L
E
V
L
T
P
Y
E
L
R
R
V
E
G
D
E
R
V
R
W
A
V
V
F
H
N
Q
-
T
Q
E
E
L
-
A
L
E
V
D
A
V
L
I
L
A
G
Y
I
T
K
L
G
P
L
A
N
W
G
L
A
L
E
-
K
N
-
K
I
K
V
D
T
-----
T
M
-----
A
-----
T
S
I
P
G
V
Y
A
C
G
D
I
V
T
Y
P
G
K
L
P
L
I
V
L
G
F
G
E
A
A
I
A
A
N
H
A
A
A
Y
A
N
P
A
L
K
V
N
P
G
H
S
S
E
-
53
HHSearch
65.84
37%
-11
- C1 -
-
3AB1
1
FENR_CHLTE
B:
[13-334]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
M
R
D
L
T
I
I
G
G
G
P
T
G
I
F
A
A
F
Q
C
G
M
N
N
I
S
C
R
I
I
E
-
S
M
P
Q
L
G
G
Q
L
A
A
L
Y
P
E
K
H
I
Y
D
V
A
G
-
F
-
P
-
E
V
P
A
I
D
L
V
E
S
L
W
A
Q
A
E
R
Y
N
P
D
V
---
V
L
N
E
T
V
T
K
Y
---
T
K
L
D--
D
-
G
-
T
-
F
E
T
-
R
T
-
N
T
G
N
V
-
Y
R
S
-
R
A
V
L
I
A
A
G
L
G
A
F
E
P
R
K
L
P
Q
L
G
N
I
D
H
L
---
T
GS
S
V
Y
-
Y
-
A
V
K
S
V
E
D
---
F
K
G
K
R
V
V
I
V
G
G
G
D
S
A
L
D
W
T
V
G
L
I
K
-
N
A
-
A
S
V
-
T
-
L
V
H
R
G
H
E
F
Q
G
----
H
GKTA
H
-
E
V
E
R
-
A
R
----
A
N
-
G
T
-
I
D
V
Y
L
E
T
E
V
A
S
I
E
E
S
N
G
V
L
T
R
V
H
L
R
S
S
-
D
G
S
K
W
-
T
V
E
A
D
R
L
L
I
L
I
G
F
K
S
N
L
G
P
L
A
R
W
D
L
E
L
Y
-
E
N
-
A
L
V
V
D
S
-----
H
M
-----
K
-----
T
S
V
D
G
L
Y
A
A
G
D
I
A
Y
Y
P
G
K
L
K
I
I
Q
T
G
L
S
E
A
T
M
A
V
R
H
S
L
S
Y
I
K
P
G
E
K
I
R
-------
22
PsiBlast_CBE
64.51
37%
-9
- C1 -
-
3AB1
1
FENR_CHLTE
B:
[14-334]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
R
D
L
T
I
I
G
G
G
P
T
G
I
F
A
A
F
Q
C
G
M
N
N
I
S
C
R
I
I
E
-
S
M
P
Q
L
G
G
Q
L
A
A
L
Y
P
E
K
H
I
Y
D
V
A
G
-
F
-
P
-
E
V
P
A
I
D
L
V
E
S
L
W
A
Q
A
E
R
Y
N
P
D
V
---
V
L
N
E
T
V
T
K
Y
---
T
K
L
---
D
-
D
G
T
-
F
E
T
-
R
T
-
N
-
T
G
N
V
Y
R
S
-
R
A
V
L
I
A
A
G
L
G
A
F
E
P
R
K
L
P
-
Q
L
G
N
I
D
H
LTG
S
--
S
V
Y
-
Y
-
A
V
K
S
V
E
D
---
F
K
G
K
R
V
V
I
V
G
G
G
D
S
A
L
D
W
T
V
G
L
I
K
N
A
A
-
S
-
V
-
T
-
L
V
H
R
G
H
E
F
Q
G
HGK-
T
----
A
-
H
E
V
E
R
A
R
----
A
N
-
G
T
-
I
D
V
Y
L
E
T
E
V
A
S
I
E
E
S
N
G
V
L
T
R
V
H
L
R
--
S
S
D
G
S
K
W
T
V
E
A
D
R
L
L
I
L
I
G
F
K
S
N
L
G
P
L
A
R
W
D
L
E
L
Y
-
E
N
-
A
L
V
V
D
S
-----
H
M
-----
K
-----
T
S
V
D
G
L
Y
A
A
G
D
I
A
Y
Y
P
G
K
L
K
I
I
Q
T
G
L
S
E
A
T
M
A
V
R
H
S
L
S
Y
I
K
P
G
E
K
I
R
-------
58
HHSearch
59.37
27%
-31
- C1 -
-
5MIT
4
?
A:
[24-325]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
Y
D
V
V
I
I
G
S
G
P
A
G
M
T
A
A
M
Y
T
A
R
S
E
M
K
T
L
L
L
E
-
R
G
-
V
P
G
G
Q
M
N
N
T
A
E
I
---
E
N
Y
P
G
-
Y
-
E
-
T
I
M
G
P
E
L
S
M
K
M
A
E
P
L
E
G
L
G
V
E
N
---
A
Y
G
-
F
V
T
G
I
---
E
D
H
---
G
-
D
-
Y
-
K
K
I
-
I
T
-
E
-
D
D
E
-
F
I
T
-
K
S
I
I
I
A
T
G
A
N
---
H
R
K
L
E
-
I
P
G
E
E
E
Y
---
G
AR
G
V
S
Y
C
-
A
V
C
D
G
A
F
---
F
R
N
Q
E
I
L
V
I
G
G
G
D
S
A
V
E
E
A
L
Y
L
T
R
-
F
G
-
Q
S
V
-
T
-
I
M
H
R
R
D
K
L
R
A
----
Q
----
E
I
I
Q
Q
R
-
A
F
----
K
E
-
E
K
-
I
N
F
I
W
D
S
V
P
M
E
I
K
G
D
D
K
K
I
Q
S
V
V
Y
K
N
V
K
T
G
E
V
T
-
E
K
A
F
G
G
I
F
I
Y
V
G
L
D
P
V
A
E
F
V
S
D
L
G
I
T
D
E
-
A
G
-
W
I
I
T
D
D
-----
H
M
-----
R
-----
T
N
I
P
G
I
F
A
V
G
D
V
R
Q
K
-
D
-
F
R
Q
I
T
T
A
V
G
D
G
A
Q
A
A
Q
E
A
Y
K
F
V
V
E
------------
56
HHSearch
56.55
24%
-24
- C1 -
-
3F8P
1
?
D:
[13-319]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
E
K
F
D
V
I
I
V
G
L
G
P
A
A
Y
G
A
A
L
Y
S
A
R
Y
M
L
K
T
L
V
I
G
-
E
T
--
P
G
G
Q
L
T
E
A
G
I
V
---
D
D
Y
L
G
-
L
-
I
-
E
I
Q
A
S
D
M
I
K
V
F
N
K
H
I
E
K
Y
E
V
P
V
---
L
L
D
-
I
V
E
K
I
---
E
N
R
---
G
-
D
-
E
-
F
V
V
-
K
T
-
K
R
K
G
E
-
F
K
A
-
D
S
V
I
L
G
I
G
V
K
---
R
R
K
L
G
-
V
P
G
E
Q
E
F
---
A
GR
G
I
S
Y
C
-
S
V
C
D
A
P
L
---
F
K
N
R
V
V
A
V
I
G
G
G
D
S
A
L
E
G
A
E
I
L
S
S
-
Y
S
-
T
K
V
-
Y
-
L
I
H
R
R
D
T
F
K
A
----
Q
P---
I
-
Y
V
E
T
-
V
K
----
K
K
-
P
N
-
V
E
F
V
L
N
S
V
V
K
E
I
K
G
D
-
K
V
V
K
Q
V
V
V
E
N
L
K
T
G
E
I
K
-
E
L
N
V
N
G
V
F
I
E
I
G
F
D
P
P
T
D
F
A
K
S
N
G
I
E
T
D
T
N
G
-
Y
I
K
V
D
E
-----
W
M
-----
R
-----
T
S
V
P
G
V
F
A
A
G
D
C
T
S
A
W
L
G
F
R
Q
V
I
T
A
V
A
Q
G
A
V
A
A
T
S
A
Y
R
Y
V
T
E
K
-----------
12
PsiBlast_PDB
55.96
29%
17
- C1 -
-
5U63
8
TRXB_HAEIN
A:
[12-320]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
I
L
G
S
G
P
A
G
Y
T
A
A
I
Y
A
A
R
A
N
L
K
P
V
L
V
T
-
G
L
Q
Q
-
G
G
Q
---
L
T
T
T
D
E
I
E
N
W
P
G
D
F
-
E
-
M
T
T
G
S
G
L
M
Q
R
M
L
Q
H
A
E
K
F
E
T
E
I
V
F
D
H
I
N
R
----
V
---
D
L
S
---
S
-
R
-
P
-
F
K
L
-
F
G
-
D
-
V
Q
N
-
F
T
C
-
D
A
L
I
I
A
T
G
A
S
A
---
R
Y
I
G
-
L
P
S
E
E
N
Y
---
K
--
G
R
G
-
V
-
S
A
C
A
T
C
D
GFF
Y
R
N
K
P
V
G
V
I
G
G
G
N
T
A
V
E
E
A
L
Y
L
A
N
-
I
A
-
S
-
T
-
V
H
L
I
H
R
R
D
S
F
R
A
E
K
I
L
I
----
D
-
R
L
Y
K
-
K
V
----
E
E
-
G
K
-
I
V
L
H
T
D
R
T
L
D
E
V
L
G
D
N
M
G
V
T
G
L
R
L
A
N
T
K
T
G
E
K
E
-
E
L
K
L
D
G
L
F
V
A
I
G
H
S
P
N
T
E
I
F
Q
G
Q
-
L
E
L
N
-
N
G
-
Y
I
V
V
K
S
GLDGN
A
T
-----
A
-----
T
S
V
E
G
V
F
A
A
G
D
V
M
D
H
N
Y
R
Q
A
I
T
S
A
G
T
G
--
C
M
A
A
L
D
A
E
R
Y
L
D
A
Q
E
----------
57
HHSearch
55.08
28%
-7
- C1 -
-
5UWY
1
?
A:
[2-306]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
A
M
Y
D
T
L
I
I
G
S
G
P
A
G
M
T
A
A
L
Y
A
A
R
S
N
L
S
V
A
I
I
E
-
Q
G
A
-
P
G
G
Q
M
N
N
T
F
D
I
---
E
N
Y
P
G
-
Y
-
D
-
H
I
S
G
P
E
L
A
M
K
M
Y
E
P
L
E
K
F
N
V
E
N
---
I
Y
G
-
I
V
Q
K
I
---
E
N
F
---
G
---
D
-
Y
K
C
V
L
T
-
E
-
D
A
S
-
Y
E
A
-
K
T
V
I
I
A
T
G
A
K
---
Y
R
V
L
G
-
V
P
G
E
E
Y
Y
---
T
SR
G
V
S
Y
C
-
A
V
C
D
G
A
F
---
F
R
D
Q
D
L
L
V
V
G
G
G
D
S
A
V
E
E
A
I
Y
L
T
Q
-
F
A
-
K
K
V
-
T
-
V
V
H
R
R
D
Q
L
R
A
----
Q
----
K
I
L
Q
D
R
-
A
F
----
A
N
-
D
K
-
V
D
F
I
W
D
S
V
V
K
E
I
Q
G
N
D
I
K
V
S
N
V
L
I
E
N
V
K
T
G
Q
V
T
-
D
H
A
F
G
G
V
F
I
Y
V
G
M
N
P
V
T
G
M
V
K
D
L
E
I
T
D
S
-
E
G
-
W
I
I
T
D
D
-----
H
M
-----
R
-----
T
S
I
P
G
I
F
A
I
G
D
V
R
Q
K
-
D
-
L
R
Q
I
T
T
A
V
G
D
G
A
I
A
G
Q
G
V
Y
H
Y
L
E
S
F
-----------
60
HHSearch
55.00
24%
6
- C1 -
-
1FL2
1
AHPF_ECOLI
A:
[1-308]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
Y
D
V
L
I
V
G
S
G
P
A
G
A
A
A
A
I
Y
S
A
R
K
G
I
R
T
G
L
M
G
-
E
--
R
F
G
G
Q
I
L
D
T
V
D
I
---
E
N
Y
I
S
-
V
-
P
-
K
T
E
G
Q
K
L
A
G
A
L
K
V
H
V
D
E
Y
D
V
D
V
---
I
D
S
Q
S
A
S
K
L
---
I
P
A
AVE
G
-
G
-
L
-
H
Q
I
-
E
T
A
S
-
G
A
V
-
L
K
A
-
R
S
I
I
V
A
T
G
A
K
---
W
R
N
M
N
-
V
P
G
E
D
Q
Y
RT-
K
--
G
V
T
Y
C
-
P
H
C
D
G
P
L
---
F
K
G
K
R
V
A
V
I
G
G
G
N
S
G
V
E
A
A
I
D
L
A
G
-
I
V
-
E
H
V
-
T
-
L
L
E
F
A
P
E
M
K
A
----
D
----
Q
-
V
L
Q
D
-
K
L
----
R
S
L
K
N
-
V
D
I
I
L
N
A
Q
T
T
E
V
K
G
D
G
S
K
V
V
G
L
E
Y
R
D
R
V
S
G
D
I
H
-
N
I
E
L
A
G
I
F
V
Q
I
G
L
L
P
N
T
N
W
L
E
G
-
A
V
E
R
N
R
M
G
-
E
I
I
I
D
A
-----
K
C
-----
E
-----
T
N
V
K
G
V
F
A
A
G
D
C
T
T
V
P
--
Y
K
Q
I
I
I
A
T
G
E
G
A
K
A
S
L
S
A
F
D
Y
L
I
R
T
K
----------
11
PsiBlast_PDB
53.97
27%
26
- C1 -
-
5MJK
2
?
A:
[25-323]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
D
V
V
I
I
G
S
G
P
A
G
M
T
A
A
M
Y
T
A
R
S
E
M
K
T
L
L
L
E
R
G
V
P
--
G
G
Q
---
M
N
N
T
A
E
I
E
N
Y
P
G
-
Y
-
E
-
T
I
M
G
P
E
L
S
M
K
M
A
E
P
L
E
G
L
G
V
E
----
N
A
Y
G
F
V
T
G
I
---
E
D
H
---
G
-
D
-
Y
-
K
K
I
-
I
T
-
E
-
D
D
E
-
F
I
T
-
K
S
I
I
I
A
T
G
A
---
N
H
R
K
L
E
-
I
P
G
E
E
E
Y
GA-
R
--
G
V
S
-
Y
C
A
V
C
D
G
A
F
---
F
R
N
Q
E
I
L
V
I
G
G
G
D
S
A
V
E
E
A
L
Y
L
T
R
-
F
G
-
Q
-
S
V
T
-
I
M
H
R
R
D
K
L
R
A
----
Q
----
E
-
I
I
Q
Q
R
A
F
----
K
E
-
E
K
-
I
N
F
I
W
D
S
V
P
M
E
I
K
G
D
D
K
K
I
Q
S
V
V
Y
K
N
V
K
T
G
E
V
T
-
E
K
A
F
G
G
I
F
I
Y
V
G
L
D
P
V
A
E
F
V
S
D
L
G
I
T
D
E
-
A
G
-
W
I
I
T
D
D
-----
H
M
-----
R
-----
T
N
I
P
G
I
F
A
V
G
D
V
R
Q
K
D
F
R
--
Q
I
T
T
A
V
G
D
G
A
Q
A
A
Q
E
A
Y
K
F
V
--------------
15
PsiBlast_PDB
53.86
28%
19
- C1 -
-
5VT3
5
?
A:
[12-317]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
I
L
G
S
G
P
A
G
Y
T
A
A
V
Y
A
A
R
A
N
L
N
P
V
L
I
T
-
G
M
Q
Q
-
G
G
Q
---
L
T
T
T
T
E
V
E
N
W
P
G
-
D
-
P
E
G
L
T
G
P
G
L
M
D
R
M
K
E
H
A
E
R
F
E
T
E
I
IFD
H
I
N
E
----
V
---
D
F
S
---
T
-
R
-
P
-
F
V
L
-
K
G
-
D
-
A
A
S
-
Y
S
C
-
D
A
L
I
I
S
T
G
A
S
A
---
K
Y
L
G
-
L
E
S
E
E
A
F
---
K
--
G
R
G
-
V
-
S
A
C
A
T
C
D
GFF
Y
R
N
Q
K
V
A
V
V
G
G
G
N
T
A
V
E
E
A
L
Y
L
S
N
-
I
A
-
A
-
E
-
V
H
L
I
H
R
R
D
S
F
R
A
E
K
I
L
I
----
N
-
R
L
M
D
-
K
V
----
Q
N
-
G
N
-
I
V
L
H
T
D
R
V
L
D
E
V
L
G
D
E
M
G
V
T
G
V
R
L
K
D
V
K
T
G
G
T
E
-
E
L
D
V
M
G
A
F
I
A
I
G
H
S
P
N
T
Q
I
F
Q
G
Q
-
L
D
M
K
-
D
G
-
Y
I
L
V
K
S
-----
G
L
-----
E
GNATQ
T
S
V
E
G
I
F
A
A
G
D
V
M
D
H
N
Y
R
Q
A
I
T
S
A
G
T
G
--
C
M
A
A
L
D
A
E
R
Y
L
D
-------------
64
HHSearch
53.60
28%
17
- C1 -
-
5VT3
5
?
B:
[7-320]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
K
H
S
K
L
L
I
L
G
S
G
P
A
G
Y
T
A
A
V
Y
A
A
R
A
N
L
N
P
V
L
I
T
-
G
M
Q
-
Q
G
G
Q
L
T
T
T
T
E
V
---
E
N
W
P
G
-
D
P
E
-
G
L
T
G
P
G
L
M
D
R
M
K
E
H
A
E
R
F
E
T
E
I
---
I
F
D
H
-
I
N
E
V
---
D
F
S
---
T
-
R
-
P
-
F
V
L
-
K
G
-
D
-
A
A
S
-
Y
S
C
-
D
A
L
I
I
S
T
G
A
S
---
A
K
Y
L
G
-
L
E
S
E
E
A
F
---
K
GR
G
V
S
A
C
-
A
T
C
D
G
F
F
---
Y
R
N
Q
K
V
A
V
V
G
G
G
N
T
A
V
E
E
A
L
Y
L
S
N
-
I
A
-
A
E
V
-
H
-
L
I
H
R
R
D
S
F
R
A
----
E
K
I
L
I
N
-
R
L
M
D
-
K
V
----
Q
N
-
G
N
-
I
V
L
H
T
D
R
V
L
D
E
V
L
G
D
E
M
G
V
T
G
V
R
L
K
D
V
K
T
G
G
T
E
-
E
L
D
V
M
G
A
F
I
A
I
G
H
S
P
N
T
Q
I
F
Q
G
-
Q
L
D
M
K
-
D
G
-
Y
I
L
V
K
S
-----
G
L
EGNAT
Q
-----
T
S
V
E
G
I
F
A
A
G
D
V
M
D
H
-
N
-
Y
R
Q
A
I
T
S
A
G
T
G
C
M
A
A
L
D
A
E
R
Y
L
D
S
L
N
----------
69
Fugue
53.58
25%
38
- C1 -
-
1HYU
1
AHPF_SALTY
A:
[1-521]
MLD
T
N
M
K
T
Q
L
R
A
Y
L
E
KLT
K
P
V
E
L
I
A
T
L
D
DS
A
K
S
A
E
I
K
E
L
L
A
E
I
A
E
L
S
DK
V
T
F
K
E
D
NTLPVRKP
S
F
L
I
T
N
PGSQ
Q
G
P
R
F
A
G
SPLGHE
F
T
S
L
V
L
A
L
L
W
T
G
G
H
P
S
KEA
Q
S
L
L
E
Q
I
R
D
I
D
G
D
F
E
F
E
T
Y
Y
S
LSCHN
C
P
D
V
V
Q
A
L
N
L
M
A
V
L
NPR
I
K
H
T
A
I
D
GGTF
Q
N
E
I
T
E
R
NVMGVP
A
V
F
V
NGKEFGQGRMT
L
T
E
I
V
A
K
V
D
TGAEK
R
A
A
E
A
L
N
K
R
D
A
Y
D
V
L
I
V
G
S
G
P
A
G
A
A
A
A
V
Y
S
A
R
K
G
I
R
T
G
L
M
G
-
E
R
F
--
G
G
---
Q
V
L
D
T
V
D
I
E
N
Y
I
S
-
V
-
P
-
K
T
E
G
Q
K
L
A
G
A
L
K
A
H
V
S
D
Y
D
V
D
V
---
I
D
S
Q
S
A
S
K
L
V
P
A
A
T
E
---
G
-
G
-
L
-
H
Q
I
-
E
T
-
A
-
S
G
A
-
V
L
K
-
A
R
S
I
I
I
A
T
G
--
A
K
W
R
N
M
N
-
V
P
G
E
D
Q
Y
RT-
K
--
G
V
T
-
Y
C
P
H
C
D
G
P
L
---
F
K
G
K
R
V
A
V
I
G
G
G
N
S
G
V
E
A
A
I
D
L
A
G
-
I
V
E
H
-
V
-
T
-
L
L
E
F
A
P
E
M
K
A
----
D
----
Q
-
V
L
Q
D
-
K
V
----
R
S
-
L
K
N
V
D
I
I
L
N
A
Q
T
T
E
V
K
G
D
G
S
K
V
V
G
L
E
Y
R
D
R
V
S
G
D
I
H
-
S
V
A
L
A
G
I
F
V
Q
I
G
L
L
P
N
T
H
W
L
E
G
-
A
L
E
R
N
-
R
M
G
E
I
I
I
D
A
-----
K
C
-----
E
-----
T
S
V
K
G
V
F
A
A
G
D
C
T
--
T
V
P
Y
K
Q
I
I
I
A
T
G
E
G
A
K
A
S
L
S
A
F
D
Y
L
I
R
T
K
I
A
--------