@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : spr1432: (2018-01-12 )
MSRKPFIAGNWKMNKNPEEAKAFVEAVASKLPSSDLVEAGIAAPALDLTTVLAVAKGSNLKVAAQNCYFENAGAFTGETSPQVLKEIGTDYVVIGHSERRDYFHETDEDINKKAKAIFANGMLPIICCGESLETYEAGKAAEFVGAQVSAALAGLTAEQVAASVIAYEPIWAIGTGKSASQDDAQKMCKVVRDVVAADFGQEVADKVRVQYGGSVKPENVASYMACPDVDGALVGGASLEAESFLALLDFVK
Atome Classification :
(82 SA)
.........10........20......-..-30--...--.....40....-...---.50...--.....60.--.......70........80........90........100.......110.......120.......130.......140.......150.......160.--......170.......180.......190.......--200.......210.......220.......230.......240.......250
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MSRK
P
F
I
AGNWKMNK
N
P
E
E
A
K
A
F
V
E
A
V
-
A
S
-KL--P
S
S
--
D
L
V
E
AGIAAP
A
-
L
D
L
---
T
T
V
L
A
V--AKGSN
L
K
V
--
A
AQN
C
Y
FENAGAFTGET
S
P
Q
V
L
K
EIGT
D
Y
V
V
I
G
H
S
E
R
R
D
YFHE
T
D
E
D
I
N
K
K
A
K
A
I
FANG
M
L
P
I
I
CCGESL
E
T
YEAG
K
A
A
E
F
V
G
A
Q
V
S
A
A
L
AGL
T
A
E
Q
V
A
A
S
--
V
IAYEP
I
W
A
IGTGKSA
S
Q
D
D
A
Q
K
M
C
K
V
V
R
D
V
V
A
A
D
F
--
G
Q
E
V
A
D
K
V
R
V
Q
YGGSV
K
P
E
N
V
A
S
Y
MACPDVDGALVGGASL
E
A
E
S
F
L
A
L
L
D
FVK
1
PsiBlast_PDB
91.49
100%
-104
- C6 -
-
5IBX
-
TPIS_STRP2
C:
[5-254]
-
S
R
K
P
F
I
A
G
N
W
K
M
N
K
N
P
E
E
A
K
A
F
V
E
A
V
-
A
S
-
K
L
--
P
S
S
--
D
L
V
E
A
G
I
A
A
P
A
-
L
D
L
---
T
T
V
L
A
V
--
A
K
G
S
N
L
K
V
--
A
A
Q
N
C
Y
F
E
N
A
G
A
F
T
G
E
T
S
P
Q
V
L
K
E
I
G
T
D
Y
V
V
I
G
H
S
E
R
R
D
Y
F
H
E
T
D
E
D
I
N
K
K
A
K
A
I
F
A
N
G
M
L
P
I
I
C
C
G
E
S
L
E
T
Y
E
A
G
K
A
A
E
F
V
G
A
Q
V
S
A
A
L
A
G
L
T
A
E
Q
V
A
A
S
--
V
I
A
Y
E
P
I
W
A
I
G
T
G
K
S
A
S
Q
D
D
A
Q
K
M
C
K
V
V
R
D
V
V
A
A
D
F
--
G
Q
E
V
A
D
K
V
R
V
Q
Y
G
G
S
V
K
P
E
N
V
A
S
Y
M
A
C
P
D
V
D
G
A
L
V
G
G
A
S
L
E
A
E
S
F
L
A
L
L
D
F
V
-
133
HHSearch
89.29
100%
-99
- C6 -
-
5IBX
-
TPIS_STRP2
H:
[5-255]
-
S
R
K
P
F
I
A
G
N
W
K
M
N
K
N
P
E
E
A
K
A
F
V
E
A
V
-
A
S
-
K
L
--
P
S
S
--
D
L
V
E
A
G
I
A
A
P
A
-
L
D
L
---
T
T
V
L
A
V
--
A
K
G
S
N
L
K
V
--
A
A
Q
N
C
Y
F
E
N
A
G
A
F
T
G
E
T
S
P
Q
V
L
K
E
I
G
T
D
Y
V
V
I
G
H
S
E
R
R
D
Y
F
H
E
T
D
E
D
I
N
K
K
A
K
A
I
F
A
N
G
M
L
P
I
I
C
C
G
E
S
L
E
T
Y
E
A
G
K
A
A
E
F
V
G
A
Q
V
S
A
A
L
A
G
L
T
A
E
Q
V
A
A
S
--
V
I
A
Y
E
P
I
W
A
I
G
T
G
K
S
A
S
Q
D
D
A
Q
K
M
C
K
V
V
R
D
V
V
A
A
D
F
--
G
Q
E
V
A
D
K
V
R
V
Q
Y
G
G
S
V
K
P
E
N
V
A
S
Y
M
A
-
P
D
V
D
G
A
L
V
G
G
A
S
L
E
A
E
S
F
L
A
L
L
D
F
V
K
8
PsiBlast_PDB
81.19
55%
-105
- C6 -
-
2BTM
1
TPIS_GEOSE
A:
[1-247]
--
R
K
P
I
I
A
G
N
W
K
M
N
G
T
L
A
E
A
V
Q
F
V
E
D
V
-
K
G
-
H
V
--
P
P
A
--
D
E
V
I
S
V
V
C
A
P
F
-
L
F
L
---
D
R
L
V
Q
A
--
A
D
G
T
D
L
K
I
--
G
A
Q
T
M
H
F
A
D
Q
G
A
Y
T
G
E
V
S
P
V
M
L
K
D
L
G
V
T
Y
V
I
L
G
H
S
E
R
R
Q
M
F
A
E
T
D
E
T
V
N
K
K
V
L
A
A
F
T
R
G
L
I
P
I
I
C
C
G
E
S
L
E
E
R
E
A
G
Q
T
N
A
V
V
A
S
Q
V
E
K
A
L
A
G
L
T
P
E
Q
V
K
Q
A
--
V
I
A
Y
E
P
I
W
A
I
G
T
G
K
S
S
T
P
E
D
A
N
S
V
C
G
H
I
R
S
V
V
S
R
L
F
--
G
P
E
A
A
E
A
I
R
I
Q
Y
G
G
S
V
K
P
D
N
I
R
D
F
L
A
Q
Q
Q
I
D
G
A
L
V
G
G
A
S
L
E
P
A
S
F
L
Q
L
V
E
---
149
HHSearch
80.90
54%
-106
- C6 -
-
2BTM
1
TPIS_GEOSE
A:
[1-250]
--
R
K
P
I
I
A
G
N
W
K
M
N
G
T
L
A
E
A
V
Q
F
V
E
D
V
-
K
G
-
H
V
--
P
P
A
--
D
E
V
I
S
V
V
C
A
P
F
-
L
F
L
---
D
R
L
V
Q
A
--
A
D
G
T
D
L
K
I
--
G
A
Q
T
M
H
F
A
D
Q
G
A
Y
T
G
E
V
S
P
V
M
L
K
D
L
G
V
T
Y
V
I
L
G
H
S
E
R
R
Q
M
F
A
E
T
D
E
T
V
N
K
K
V
L
A
A
F
T
R
G
L
I
P
I
I
C
C
G
E
S
L
E
E
R
E
A
G
Q
T
N
A
V
V
A
S
Q
V
E
K
A
L
A
G
L
T
P
E
Q
V
K
Q
A
--
V
I
A
Y
E
P
I
W
A
I
G
T
G
K
S
S
T
P
E
D
A
N
S
V
C
G
H
I
R
S
V
V
S
R
L
F
--
G
P
E
A
A
E
A
I
R
I
Q
Y
G
G
S
V
K
P
D
N
I
R
D
F
L
A
Q
Q
Q
I
D
G
A
L
V
G
G
A
S
L
E
P
A
S
F
L
Q
L
V
E
A
G
R
33
PsiBlast_CBE
80.77
55%
-102
- C6 -
-
2BTM
1
TPIS_GEOSE
B:
[1-247]
--
R
K
P
I
I
A
G
N
W
K
M
N
G
T
L
A
E
A
V
Q
F
V
E
D
V
-
K
G
-
H
V
--
P
P
A
--
D
E
V
I
S
V
V
C
A
P
F
-
L
F
L
---
D
R
L
V
Q
A
--
A
D
G
T
D
L
K
I
--
G
A
Q
T
M
H
F
A
D
Q
G
A
Y
T
G
E
V
S
P
V
M
L
K
D
L
G
V
T
Y
V
I
L
G
H
S
E
R
R
Q
M
F
A
E
T
D
E
T
V
N
K
K
V
L
A
A
F
T
R
G
L
I
P
I
I
C
C
G
E
S
L
E
E
R
E
A
G
Q
T
N
A
V
V
A
S
Q
V
E
K
A
L
A
G
L
T
P
E
Q
V
K
Q
A
--
V
I
A
Y
E
P
I
W
A
I
G
T
G
K
S
S
T
P
E
D
A
N
S
V
C
G
H
I
R
S
V
V
S
R
L
F
--
G
P
E
A
A
E
A
I
R
I
Q
Y
G
G
S
V
K
P
D
N
I
R
D
F
L
A
Q
Q
Q
I
D
G
A
L
V
G
G
A
S
L
E
P
A
S
F
L
Q
L
V
E
---
9
PsiBlast_PDB
80.42
54%
-102
- C6 -
-
1BTM
1
TPIS_GEOSE
A:
[1-247]
--
R
K
P
I
I
A
G
N
W
K
M
H
K
T
L
A
E
A
V
Q
F
V
E
D
V
-
K
G
-
H
V
--
P
P
A
--
D
E
V
I
S
V
V
C
A
P
F
-
L
F
L
---
D
R
L
V
Q
A
--
A
D
G
T
D
L
K
I
--
G
A
Q
T
M
H
F
A
D
Q
G
A
Y
T
G
E
V
S
P
V
M
L
K
D
L
G
V
T
Y
V
I
L
G
H
S
E
R
R
Q
M
F
A
E
T
D
E
T
V
N
K
K
V
L
A
A
F
T
R
G
L
I
P
I
I
C
C
G
E
S
L
E
E
R
E
A
G
Q
T
N
A
V
V
A
S
Q
V
E
K
A
L
A
G
L
T
P
E
Q
V
K
Q
A
--
V
I
A
Y
E
P
I
W
A
I
G
T
G
K
S
S
T
P
E
D
A
N
S
V
C
G
H
I
R
S
V
V
S
R
L
F
--
G
P
E
A
A
E
A
I
R
I
Q
Y
G
G
S
V
K
P
D
N
I
R
D
F
L
A
Q
Q
Q
I
D
G
P
L
V
G
G
A
S
L
E
P
A
S
F
L
Q
L
V
E
---
34
PsiBlast_CBE
78.82
54%
-99
- C6 -
-
1BTM
1
TPIS_GEOSE
B:
[1-247]
--
R
K
P
I
I
A
G
N
W
K
M
H
K
T
L
A
E
A
V
Q
F
V
E
D
V
-
K
G
-
H
V
--
P
P
A
--
D
E
V
I
S
V
V
C
A
P
F
-
L
F
L
---
D
R
L
V
Q
A
--
A
D
G
T
D
L
K
I
--
G
A
Q
T
M
H
F
A
D
Q
G
A
Y
T
G
E
V
S
P
V
M
L
K
D
L
G
V
T
Y
V
I
L
G
H
S
E
R
R
Q
M
F
A
E
T
D
E
T
V
N
K
K
V
L
A
A
F
T
R
G
L
I
P
I
I
C
C
G
E
S
L
E
E
R
E
A
G
Q
T
N
A
V
V
A
S
Q
V
E
K
A
L
A
G
L
T
P
E
Q
V
K
Q
A
--
V
I
A
Y
E
P
I
W
A
I
G
T
G
K
S
S
T
P
E
D
A
N
S
V
C
G
H
I
R
S
V
V
S
R
L
F
--
G
P
E
A
A
E
A
I
R
I
Q
Y
G
G
S
V
K
P
D
N
I
R
D
F
L
A
Q
Q
Q
I
D
G
P
L
V
G
G
A
S
L
E
P
A
S
F
L
Q
L
V
E
---
20
PsiBlast_PDB
78.40
47%
-112
- C6 -
-
4Y96
-
?
A:
[6-251]
-
T
R
K
K
F
V
A
G
N
W
K
M
N
T
T
L
A
E
A
K
A
L
G
A
A
V
-
A
K
-
G
V
---
T
D
--
D
R
V
T
V
A
V
F
P
P
Y
-
P
W
L
---
T
A
V
G
E
V
--
L
K
G
S
P
V
A
L
--
G
A
Q
D
V
S
S
E
K
K
G
A
F
T
G
E
V
S
P
A
M
L
L
E
T
G
C
K
Y
A
L
I
G
H
S
E
R
R
H
I
I
G
E
S
E
T
F
I
N
H
K
V
H
T
A
L
E
E
G
L
S
V
V
L
C
M
G
E
T
L
A
E
R
E
R
G
L
Q
E
R
V
F
Q
R
Q
V
Y
A
A
C
A
G
L
T
D
E
Q
F
G
R
I
--
V
I
A
Y
E
P
V
W
A
I
G
T
G
K
V
A
T
P
E
Q
A
Q
E
A
H
A
F
V
R
S
K
L
R
L
L
Y
--
G
D
K
I
A
D
S
T
P
I
V
Y
G
G
S
V
T
P
D
N
T
V
G
L
M
S
Q
P
D
V
D
G
A
L
V
G
G
A
S
L
K
A
D
S
F
L
A
I
V
----
134
HHSearch
78.26
47%
-107
- C6 -
-
4Y96
-
?
B:
[6-254]
-
T
R
K
K
F
V
A
G
N
W
K
M
N
T
T
L
A
E
A
K
A
L
G
A
A
V
-
A
K
-
G
V
---
T
D
--
D
R
V
T
V
A
V
F
P
P
Y
-
P
W
L
---
T
A
V
G
E
V
--
L
K
G
S
P
V
A
L
--
G
A
Q
D
V
S
S
E
K
K
G
A
F
T
G
E
V
S
P
A
M
L
L
E
T
G
C
K
Y
A
L
I
G
H
S
E
R
R
H
I
I
G
E
S
E
T
F
I
N
H
K
V
H
T
A
L
E
E
G
L
S
V
V
L
C
M
G
E
T
L
A
E
R
E
R
G
L
Q
E
R
V
F
Q
R
Q
V
Y
A
A
C
A
G
L
T
D
E
Q
F
G
R
I
--
V
I
A
Y
E
P
V
W
A
I
G
T
G
K
V
A
T
P
E
Q
A
Q
E
A
H
A
F
V
R
S
K
L
R
L
L
Y
--
G
D
K
I
A
D
S
T
P
I
V
Y
G
G
S
V
T
P
D
N
T
V
G
L
M
S
Q
P
D
V
D
G
A
L
V
G
G
A
S
L
K
A
D
S
F
L
A
I
V
K
A
A
-
12
PsiBlast_PDB
77.79
45%
-109
- C6 -
-
1B9B
-
PGKT_THEMA
A:
[2-246]
-
T
R
K
L
I
L
A
G
N
W
K
M
H
K
T
I
S
E
A
K
K
F
V
S
L
L
-
V
N
-
E
L
--
H
D
V
--
K
E
F
E
I
V
V
C
P
P
F
-
T
A
L
---
S
E
V
G
E
I
--
L
S
G
R
N
I
K
L
--
G
A
Q
N
V
F
Y
E
D
Q
G
A
F
T
G
E
I
S
P
L
M
L
Q
E
I
G
V
E
Y
V
I
V
G
H
S
E
R
R
R
I
F
K
E
D
D
E
F
I
N
R
K
V
K
A
V
L
E
K
G
M
T
P
I
L
C
V
G
E
T
L
E
E
R
E
K
G
L
T
F
C
V
V
E
K
Q
V
R
E
G
F
Y
G
L
D
K
E
E
A
K
R
V
--
V
I
A
Y
E
P
V
W
A
I
G
T
G
R
V
A
T
P
Q
Q
A
Q
E
V
H
A
F
I
R
K
L
L
S
E
M
Y
--
D
E
E
T
A
G
S
I
R
I
L
Y
G
G
S
I
K
P
D
N
F
L
G
L
I
V
Q
K
D
I
D
G
G
L
V
G
G
A
S
L
K
-
E
S
F
I
E
L
-----
135
HHSearch
77.65
44%
-119
- C6 -
-
1B9B
-
B:
[1-250]
I
T
R
K
L
I
L
A
G
N
W
K
M
H
K
T
I
S
E
A
K
K
F
V
S
L
L
-
V
N
-
E
L
--
H
D
V
--
K
E
F
E
I
V
V
C
P
P
F
-
T
A
L
---
S
E
V
G
E
I
--
L
S
G
R
N
I
K
L
--
G
A
Q
N
V
F
Y
E
D
Q
G
A
F
T
G
E
I
S
P
L
M
L
Q
E
I
G
V
E
Y
V
I
V
G
H
S
E
R
R
R
I
F
K
E
D
D
E
F
I
N
R
K
V
K
A
V
L
E
K
G
M
T
P
I
L
C
V
G
E
T
L
E
E
R
E
K
G
L
T
F
C
V
V
E
K
Q
V
R
E
G
F
Y
G
L
D
K
E
E
A
K
R
V
--
V
I
A
Y
E
P
V
W
A
I
G
T
G
R
V
A
T
P
Q
Q
A
Q
E
V
H
A
F
I
R
K
L
L
S
E
M
Y
--
D
E
E
T
A
G
S
I
R
I
L
Y
G
G
S
I
K
P
D
N
F
L
G
L
I
V
Q
K
D
I
D
G
G
L
V
G
G
A
S
L
K
E
-
S
F
I
E
L
A
R
I
M
-
10
PsiBlast_PDB
76.65
52%
-109
- C6 -
-
4Y8F
-
TPIS_CLOPE
A:
[5-251]
--
R
T
P
I
I
A
G
N
W
K
M
H
Y
T
I
D
E
A
V
K
L
V
E
E
L
--
K
-
P
L
--
V
K
D
--
A
K
C
E
V
V
V
C
P
T
F
-
V
C
L
---
D
A
V
K
K
A
--
V
E
G
T
N
I
K
V
--
G
A
Q
N
M
H
F
E
E
K
G
A
F
T
G
E
I
A
P
R
M
L
E
A
M
N
I
D
Y
V
I
I
G
H
S
E
R
R
E
Y
F
N
E
T
D
E
T
C
N
K
K
V
K
A
A
F
A
H
N
L
T
P
I
L
C
C
G
E
T
L
E
Q
R
E
N
G
T
T
N
D
V
I
K
A
Q
I
T
A
D
L
E
G
L
T
K
E
Q
A
E
K
V
--
V
I
A
Y
E
P
I
W
A
I
G
T
G
K
T
A
T
S
D
Q
A
N
E
T
I
A
A
I
R
A
M
V
A
E
M
F
--
G
Q
E
V
A
D
K
V
R
I
Q
Y
G
G
S
V
K
P
N
T
I
A
E
Q
M
A
K
S
D
I
D
G
A
L
V
G
G
A
S
L
V
A
A
D
F
A
Q
I
V
N
Y
--
138
HHSearch
76.07
52%
-107
- C6 -
-
4Y8F
-
TPIS_CLOPE
A:
[3-250]
H
M
R
T
P
I
I
A
G
N
W
K
M
H
Y
T
I
D
E
A
V
K
L
V
E
E
L
-
K
P
-
L
V
---
K
D
--
A
K
C
E
V
V
V
C
P
T
F
-
V
C
L
---
D
A
V
K
K
A
--
V
E
G
T
N
I
K
V
--
G
A
Q
N
M
H
F
E
E
K
G
A
F
T
G
E
I
A
P
R
M
L
E
A
M
N
I
D
Y
V
I
I
G
H
S
E
R
R
E
Y
F
N
E
T
D
E
T
C
N
K
K
V
K
A
A
F
A
H
N
L
T
P
I
L
C
C
G
E
T
L
E
Q
R
E
N
G
T
T
N
D
V
I
K
A
Q
I
T
A
D
L
E
G
L
T
K
E
Q
A
E
K
V
--
V
I
A
Y
E
P
I
W
A
I
G
T
G
K
T
A
T
S
D
Q
A
N
E
T
I
A
A
I
R
A
M
V
A
E
M
F
--
G
Q
E
V
A
D
K
V
R
I
Q
Y
G
G
S
V
K
P
N
T
I
A
E
Q
M
A
K
S
D
I
D
G
A
L
V
G
G
A
S
L
V
A
A
D
F
A
Q
I
V
N
---
4
PsiBlast_PDB
75.19
58%
-18
- C6 -
-
3UWV
2
TPIS_STAAR
A:
[10-261]
--
R
T
P
I
I
A
G
N
W
K
M
N
K
T
V
Q
E
A
K
D
F
V
N
A
L
-
P
T
--
L
--
P
D
S
--
K
E
V
E
S
V
I
C
A
P
A
-
I
Q
L
D
A
L
T
T
A
V
K
E
--
G
K
A
Q
G
L
E
I
--
G
A
Q
N
T
Y
F
E
D
N
G
A
F
T
G
E
T
S
P
V
A
L
A
D
L
G
V
K
Y
V
V
I
G
H
S
E
R
R
E
L
F
H
E
T
D
E
E
I
N
K
K
A
H
A
I
F
K
H
G
M
T
P
I
I
C
V
G
E
T
D
E
E
R
E
S
G
K
A
N
D
V
V
G
E
Q
V
K
K
A
V
A
G
L
S
E
D
Q
L
K
S
V
--
V
I
A
Y
E
P
I
W
A
I
G
T
G
K
S
S
T
S
E
D
A
N
E
M
C
A
F
V
R
Q
T
I
A
D
L
S
--
S
K
E
V
S
E
A
T
R
I
Q
Y
G
G
S
V
K
P
N
N
I
K
E
Y
M
A
Q
T
D
I
D
G
A
L
V
G
G
A
S
L
K
V
E
D
F
V
Q
L
L
E
G
A
K
5
PsiBlast_PDB
75.15
58%
-21
- C6 -
-
3UWW
2
TPIS_STAAR
A:
[10-261]
--
R
T
P
I
I
A
G
N
W
K
M
N
K
T
V
Q
E
A
K
D
F
V
N
A
L
-
P
T
--
L
--
P
D
S
--
K
E
V
E
S
V
I
C
A
P
A
-
I
Q
L
D
A
L
T
T
A
V
K
E
--
G
K
A
Q
G
L
E
I
--
G
A
Q
N
T
Y
F
E
D
N
G
A
F
T
G
E
T
S
P
V
A
L
A
D
L
G
V
K
Y
V
V
I
G
H
S
E
R
R
E
L
F
H
E
T
D
E
E
I
N
K
K
A
H
A
I
F
K
H
G
M
T
P
I
I
C
V
G
E
T
D
E
E
R
E
S
G
K
A
N
D
V
V
G
E
Q
V
K
K
A
V
A
G
L
S
E
D
Q
L
K
S
V
--
V
I
A
Y
E
P
I
W
A
I
G
T
G
K
S
S
T
S
E
D
A
N
E
M
C
A
F
V
R
Q
T
I
A
D
L
S
--
S
K
E
V
S
E
A
T
R
I
Q
Y
G
G
S
V
K
P
N
N
I
K
E
Y
M
A
Q
T
D
I
D
G
A
L
V
G
G
A
S
L
K
V
E
D
F
V
Q
L
L
E
G
A
K
3
PsiBlast_PDB
75.06
58%
-15
- C6 -
-
3UWU
2
TPIS_STAAR
A:
[10-261]
--
R
T
P
I
I
A
G
N
W
K
M
N
K
T
V
Q
E
A
K
D
F
V
N
A
L
-
P
T
--
L
--
P
D
S
--
K
E
V
E
S
V
I
C
A
P
A
-
I
Q
L
D
A
L
T
T
A
V
K
E
--
G
K
A
Q
G
L
E
I
--
G
A
Q
N
T
Y
F
E
D
N
G
A
F
T
G
E
T
S
P
V
A
L
A
D
L
G
V
K
Y
V
V
I
G
H
S
E
R
R
E
L
F
H
E
T
D
E
E
I
N
K
K
A
H
A
I
F
K
H
G
M
T
P
I
I
C
V
G
E
T
D
E
E
R
E
S
G
K
A
N
D
V
V
G
E
Q
V
K
K
A
V
A
G
L
S
E
D
Q
L
K
S
V
--
V
I
A
Y
E
P
I
W
A
I
G
T
G
K
S
S
T
S
E
D
A
N
E
M
C
A
F
V
R
Q
T
I
A
D
L
S
--
S
K
E
V
S
E
A
T
R
I
Q
Y
G
G
S
V
K
P
N
N
I
K
E
Y
M
A
Q
T
D
I
D
G
A
L
V
G
G
A
S
L
K
V
E
D
F
V
Q
L
L
E
G
A
K
7
PsiBlast_PDB
75.00
58%
-16
- C6 -
-
3UWZ
1
TPIS_STAAR
A:
[10-261]
--
R
T
P
I
I
A
G
N
W
K
M
N
K
T
V
Q
E
A
K
D
F
V
N
A
L
-
P
T
--
L
--
P
D
S
--
K
E
V
E
S
V
I
C
A
P
A
-
I
Q
L
D
A
L
T
T
A
V
K
E
--
G
K
A
Q
G
L
E
I
--
G
A
Q
N
T
Y
F
E
D
N
G
A
F
T
G
E
T
S
P
V
A
L
A
D
L
G
V
K
Y
V
V
I
G
H
S
E
R
R
E
L
F
H
E
T
D
E
E
I
N
K
K
A
H
A
I
F
K
H
G
M
T
P
I
I
C
V
G
E
T
D
E
E
R
E
S
G
K
A
N
D
V
V
G
E
Q
V
K
K
A
V
A
G
L
S
E
D
Q
L
K
S
V
--
V
I
A
Y
E
P
I
W
A
I
G
T
G
K
S
S
T
S
E
D
A
N
E
M
C
A
F
V
R
Q
T
I
A
D
L
S
--
S
K
E
V
S
E
A
T
R
I
Q
Y
G
G
S
V
K
P
N
N
I
K
E
Y
M
A
Q
T
D
I
D
G
A
L
V
G
G
A
S
L
K
V
E
D
F
V
Q
L
L
E
G
A
K
31
PsiBlast_CBE
74.90
58%
-18
- C6 -
-
3UWV
2
TPIS_STAAR
B:
[10-261]
--
R
T
P
I
I
A
G
N
W
K
M
N
K
T
V
Q
E
A
K
D
F
V
N
A
L
-
P
T
--
L
--
P
D
S
--
K
E
V
E
S
V
I
C
A
P
A
-
I
Q
L
D
A
L
T
T
A
V
K
E
--
G
K
A
Q
G
L
E
I
--
G
A
Q
N
T
Y
F
E
D
N
G
A
F
T
G
E
T
S
P
V
A
L
A
D
L
G
V
K
Y
V
V
I
G
H
S
E
R
R
E
L
F
H
E
T
D
E
E
I
N
K
K
A
H
A
I
F
K
H
G
M
T
P
I
I
C
V
G
E
T
D
E
E
R
E
S
G
K
A
N
D
V
V
G
E
Q
V
K
K
A
V
A
G
L
S
E
D
Q
L
K
S
V
--
V
I
A
Y
E
P
I
W
A
I
G
T
G
K
S
S
T
S
E
D
A
N
E
M
C
A
F
V
R
Q
T
I
A
D
L
S
--
S
K
E
V
S
E
A
T
R
I
Q
Y
G
G
S
V
K
P
N
N
I
K
E
Y
M
A
Q
T
D
I
D
G
A
L
V
G
G
A
S
L
K
V
E
D
F
V
Q
L
L
E
G
A
K
30
PsiBlast_CBE
74.77
58%
-16
- C6 -
-
3UWW
2
TPIS_STAAR
B:
[10-260]
--
R
T
P
I
I
A
G
N
W
K
M
N
K
T
V
Q
E
A
K
D
F
V
N
A
L
-
P
T
--
L
--
P
D
S
--
K
E
V
E
S
V
I
C
A
P
A
-
I
Q
L
D
A
L
T
T
A
V
K
E
--
G
K
A
Q
G
L
E
I
--
G
A
Q
N
T
Y
F
E
D
N
G
A
F
T
G
E
T
S
P
V
A
L
A
D
L
G
V
K
Y
V
V
I
G
H
S
E
R
R
E
L
F
H
E
T
D
E
E
I
N
K
K
A
H
A
I
F
K
H
G
M
T
P
I
I
C
V
G
E
T
D
E
E
R
E
S
G
K
A
N
D
V
V
G
E
Q
V
K
K
A
V
A
G
L
S
E
D
Q
L
K
S
V
--
V
I
A
Y
E
P
I
W
A
I
G
T
G
K
S
S
T
S
E
D
A
N
E
M
C
A
F
V
R
Q
T
I
A
D
L
S
--
S
K
E
V
S
E
A
T
R
I
Q
Y
G
G
S
V
K
P
N
N
I
K
E
Y
M
A
Q
T
D
I
D
G
A
L
V
G
G
A
S
L
K
V
E
D
F
V
Q
L
L
E
G
A
-
6
PsiBlast_PDB
74.65
58%
-22
- C6 -
-
3UWY
-
TPIS_STAAR
A:
[2-253]
--
R
T
P
I
I
A
G
N
W
K
M
N
K
T
V
Q
E
A
K
D
F
V
N
A
L
-
P
T
--
L
--
P
D
S
--
K
E
V
E
S
V
I
C
A
P
A
-
I
Q
L
D
A
L
T
T
A
V
K
E
--
G
K
A
Q
G
L
E
I
--
G
A
Q
N
T
Y
F
E
D
N
G
A
F
T
G
E
T
S
P
V
A
L
A
D
L
G
V
K
Y
V
V
I
G
H
S
E
R
R
E
L
F
H
E
T
D
E
E
I
N
K
K
A
H
A
I
F
K
H
G
M
T
P
I
I
C
V
G
E
T
D
E
E
R
E
S
G
K
A
N
D
V
V
G
E
Q
V
K
K
A
V
A
G
L
S
E
D
Q
L
K
S
V
--
V
I
A
Y
E
P
I
W
A
I
G
T
G
K
S
S
T
S
E
D
A
N
E
M
C
A
F
V
R
Q
T
I
A
D
L
S
--
S
K
E
V
S
E
A
T
R
I
Q
Y
G
G
S
V
K
P
N
N
I
K
E
Y
M
A
Q
T
D
I
D
G
A
L
V
G
G
A
S
L
K
V
E
D
F
V
Q
L
L
E
G
A
K
77
PsiBlast_CBE
74.48
41%
-111
- C6 -
-
2I9E
2
?
B:
[2-244]
-
A
R
K
F
V
V
G
G
N
W
K
M
N
G
D
K
K
Q
I
N
E
I
I
G
F
L
-
K
S
-
G
---
P
L
N
--
Q
D
T
E
V
V
V
G
V
P
A
-
I
Y
L
---
E
L
V
R
T
C
--
V
P
A
S
-
I
G
V
--
A
A
Q
N
C
Y
K
V
P
K
G
A
F
T
G
E
I
S
P
A
M
I
K
D
V
G
A
D
W
V
I
L
G
H
S
E
R
R
Q
I
F
G
E
S
D
E
L
I
A
E
K
V
C
H
A
L
E
S
G
L
K
V
I
A
C
I
G
E
T
L
E
E
R
E
A
G
K
T
E
E
V
V
F
R
Q
T
K
A
I
A
A
K
V
N
--
D
W
S
N
V
--
V
I
A
Y
E
P
V
W
A
I
G
T
G
K
T
A
T
P
Q
Q
A
Q
D
V
H
K
A
L
R
Q
W
I
C
E
N
I
--
D
A
K
V
G
N
S
I
R
I
Q
Y
G
G
S
V
T
A
A
N
C
K
E
L
A
S
Q
P
D
I
D
G
F
L
V
G
G
A
S
L
K
P
E
-
F
V
D
I
I
N
---
28
PsiBlast_CBE
74.20
58%
-16
- C6 -
-
3M9Y
1
TPIS_STAAR
B:
[3-254]
--
R
T
P
I
I
A
G
N
W
K
M
N
K
T
V
Q
E
A
K
D
F
V
N
A
L
-
P
T
--
L
--
P
D
S
--
K
E
V
E
S
V
I
C
A
P
A
-
I
Q
L
D
A
L
T
T
A
V
K
E
--
G
K
A
Q
G
L
E
I
--
G
A
Q
N
T
Y
F
E
D
N
G
A
F
T
G
E
T
S
P
V
A
L
A
D
L
G
V
K
Y
V
V
I
G
H
S
E
R
R
E
L
F
H
E
T
D
E
E
I
N
K
K
A
H
A
I
F
K
H
G
M
T
P
I
I
C
V
G
E
T
D
E
E
R
E
S
G
K
A
N
D
V
V
G
E
Q
V
K
K
A
V
A
G
L
S
E
D
Q
L
K
S
V
--
V
I
A
Y
E
P
I
W
A
I
G
T
G
K
S
S
T
S
E
D
A
N
E
M
C
A
F
V
R
Q
T
I
A
D
L
S
--
S
K
E
V
S
E
A
T
R
I
Q
Y
G
G
S
V
K
P
N
N
I
K
E
Y
M
A
Q
T
D
I
D
G
A
L
V
G
G
A
S
L
K
V
E
D
F
V
Q
L
L
E
G
A
K
29
PsiBlast_CBE
74.13
58%
-19
- C6 -
-
3UWZ
1
TPIS_STAAR
B:
[10-261]
--
R
T
P
I
I
A
G
N
W
K
M
N
K
T
V
Q
E
A
K
D
F
V
N
A
L
-
P
T
--
L
--
P
D
S
--
K
E
V
E
S
V
I
C
A
P
A
-
I
Q
L
D
A
L
T
T
A
V
K
E
--
G
K
A
Q
G
L
E
I
--
G
A
Q
N
T
Y
F
E
D
N
G
A
F
T
G
E
T
S
P
V
A
L
A
D
L
G
V
K
Y
V
V
I
G
H
S
E
R
R
E
L
F
H
E
T
D
E
E
I
N
K
K
A
H
A
I
F
K
H
G
M
T
P
I
I
C
V
G
E
T
D
E
E
R
E
S
G
K
A
N
D
V
V
G
E
Q
V
K
K
A
V
A
G
L
S
E
D
Q
L
K
S
V
--
V
I
A
Y
E
P
I
W
A
I
---
K
S
S
T
S
E
D
A
N
E
M
C
A
F
V
R
Q
T
I
A
D
L
S
--
S
K
E
V
S
E
A
T
R
I
Q
Y
G
G
S
V
K
P
N
N
I
K
E
Y
M
A
Q
T
D
I
D
G
A
L
V
G
G
A
S
L
K
V
E
D
F
V
Q
L
L
E
G
A
K
75
PsiBlast_CBE
74.11
41%
-112
- C6 -
-
2I9E
3
?
D:
[2-244]
-
A
R
K
F
V
V
G
G
N
W
K
M
N
G
D
K
K
Q
I
N
E
I
I
G
F
L
-
K
S
-
G
---
P
L
N
--
Q
D
T
E
V
V
V
G
V
P
A
-
I
Y
L
---
E
L
V
R
T
C
--
V
P
A
S
-
I
G
V
--
A
A
Q
N
C
Y
K
V
P
K
G
A
F
T
G
E
I
S
P
A
M
I
K
D
V
G
A
D
W
V
I
L
G
H
S
E
R
R
Q
I
F
G
E
S
D
E
L
I
A
E
K
V
C
H
A
L
E
S
G
L
K
V
I
A
C
I
G
E
T
L
E
E
R
E
A
G
K
T
E
E
V
V
F
R
Q
T
K
A
I
A
A
K
V
N
--
D
W
S
N
V
--
V
I
A
Y
E
P
V
W
A
I
G
T
G
K
T
A
T
P
Q
Q
A
Q
D
V
H
K
A
L
R
Q
W
I
C
E
N
I
--
D
A
K
V
G
N
S
I
R
I
Q
Y
G
G
S
V
T
A
A
N
C
K
E
L
A
S
Q
P
D
I
D
G
F
L
V
G
G
A
S
L
K
P
E
-
F
V
D
I
I
N
---
32
PsiBlast_CBE
74.09
58%
-15
- C6 -
-
3UWU
1
TPIS_STAAR
B:
[10-260]
--
R
T
P
I
I
A
G
N
W
K
M
N
K
T
V
Q
E
A
K
D
F
V
N
A
L
-
P
T
--
L
--
P
D
S
--
K
E
V
E
S
V
I
C
A
P
A
-
I
Q
L
DAL
T
T
A
V
K
E
--
G
K
A
Q
G
L
E
I
--
G
A
Q
N
T
Y
F
E
D
N
G
A
F
T
G
E
T
S
P
V
A
L
A
D
L
G
V
K
Y
V
V
I
G
H
S
E
R
R
E
L
F
H
E
T
D
E
E
I
N
K
K
A
H
A
I
F
K
H
G
M
T
P
I
I
C
V
G
E
T
D
E
E
R
E
S
G
K
A
N
D
V
V
G
E
Q
V
K
K
A
V
A
G
L
S
E
D
Q
L
K
S
V
--
V
I
A
Y
E
P
I
W
A
I
G
T
G
K
S
S
T
S
E
D
A
N
E
M
C
A
F
V
R
Q
T
I
A
D
L
S
--
S
K
E
V
S
E
A
T
R
I
Q
Y
G
G
S
V
K
P
N
N
I
K
E
Y
M
A
Q
T
D
I
D
G
A
L
V
G
G
A
S
L
K
V
E
D
F
V
Q
L
L
E
G
A
-
61
PsiBlast_CBE
74.05
42%
-113
- C6 -
-
4MVA
2
?
A:
[26-270]
--
R
H
P
L
V
M
G
N
W
K
L
N
G
S
R
H
M
V
H
E
L
V
S
N
L
-
R
K
-
E
L
--
A
G
V
--
A
G
C
A
V
A
I
A
P
P
E
-
M
Y
I
---
D
M
A
K
R
E
--
A
E
G
S
H
I
M
L
--
G
A
Q
N
V
D
L
N
L
S
G
A
F
T
G
E
T
S
A
A
M
L
K
D
I
G
A
Q
Y
I
I
I
G
H
S
E
R
R
T
Y
H
K
E
S
D
E
L
I
A
K
K
F
A
V
L
K
E
Q
G
L
T
P
V
L
C
I
G
E
T
E
A
E
N
E
A
G
K
T
E
E
V
C
A
R
Q
I
D
A
V
L
K
T
Q
G
A
A
A
F
E
G
A
--
V
I
A
Y
E
P
V
W
A
I
G
T
G
K
S
A
T
P
A
Q
A
Q
A
V
H
K
F
I
R
D
H
I
-
A
K
V
--
D
A
N
I
A
E
Q
V
I
I
Q
Y
G
G
S
V
N
A
S
N
A
A
E
L
F
A
Q
P
D
I
D
G
A
L
V
G
G
A
S
L
K
A
D
A
F
A
V
I
V
----
147
HHSearch
73.42
36%
-108
- C6 -
-
4MKN
6
?
A:
[17-264]
S
S
A
K
F
F
V
G
G
N
W
K
C
N
G
S
V
A
N
V
A
K
L
V
D
E
L
-
N
A
-
G
T
---
I
P
--
R
G
V
D
V
V
V
A
P
P
F
-
I
Y
I
---
D
Y
V
M
Q
H
--
L
D
R
D
K
Y
Q
L
--
S
A
Q
N
A
W
I
G
G
N
G
A
F
T
G
E
V
S
A
E
Q
L
T
D
F
G
V
P
W
V
I
L
G
H
S
E
R
R
S
L
F
G
E
S
N
E
V
V
A
K
K
T
S
H
A
L
A
A
G
L
G
V
I
A
C
I
G
E
T
L
E
Q
R
N
S
G
S
V
F
K
V
L
D
A
Q
M
D
A
L
V
D
E
V
--
K
D
W
T
K
V
--
V
L
A
Y
E
P
V
W
A
I
G
T
G
V
V
A
S
P
E
Q
A
Q
E
V
H
A
Y
L
R
Q
Y
C
A
K
K
L
--
G
A
A
V
A
D
K
L
R
I
I
Y
G
G
S
V
S
D
T
N
C
K
D
L
S
K
Q
E
D
I
D
G
F
L
V
G
G
A
S
L
K
G
A
A
F
V
T
I
C
N
A
A
-
154
Fugue
73.33
54%
-15
- C6 -
-
2BTM
1
TPIS_GEOSE
A:
[1-250]
--
R
K
P
I
I
A
G
N
W
K
M
N
G
T
L
A
E
A
V
Q
F
V
E
D
V
-
K
G
-
H
V
--
P
P
A
--
D
E
V
I
S
V
V
C
A
P
F
-
L
F
L
---
D
R
L
V
Q
A
A
D--
G
T
D
L
K
I
--
G
A
Q
T
M
H
F
A
D
Q
G
A
Y
T
G
E
V
S
P
V
M
L
K
D
L
G
V
T
Y
V
I
L
G
H
S
E
R
R
Q
M
F
A
E
T
D
E
T
V
N
K
K
V
L
A
A
F
T
R
G
L
I
P
I
I
C
C
G
E
S
L
E
E
R
E
A
G
Q
T
N
A
V
V
A
S
Q
V
E
K
A
L
A
G
L
T
P
E
Q
V
K
Q
A
--
V
I
A
Y
E
P
I
W
A
I
G
T
G
K
S
S
T
P
E
D
A
N
S
V
C
G
H
I
R
S
V
V
S
R
L
F
--
G
P
E
A
A
E
A
I
R
I
Q
Y
G
G
S
V
K
P
D
N
I
R
D
F
L
A
Q
Q
Q
I
D
G
A
L
V
G
G
A
S
L
E
P
A
S
F
L
Q
L
V
E
A
G
R
145
HHSearch
73.15
40%
-108
- C6 -
-
2VXN
6
TPIS_LEIME
A:
[4-250]
-
K
P
Q
P
I
A
A
A
N
W
K
C
N
G
T
T
A
S
I
E
K
L
V
Q
V
F
-
N
E
-
H
T
---
I
S
--
H
D
V
Q
C
V
V
A
P
T
F
-
V
H
I
---
P
L
V
Q
A
K
--
L
R
N
P
K
Y
V
I
--
S
A
Q
N
A
I
-
A
K
S
G
A
F
T
G
E
V
S
M
P
I
L
K
D
I
G
V
H
W
V
I
L
G
H
S
E
R
R
T
Y
Y
G
E
T
D
E
I
V
A
Q
K
V
S
E
A
C
K
Q
G
F
M
V
I
A
C
I
G
E
T
L
Q
Q
R
E
A
N
Q
T
A
K
V
V
L
S
Q
T
S
A
I
A
A
K
L
T
K
D
A
W
N
Q
V
--
V
L
A
Y
E
P
V
W
A
I
G
T
G
K
V
A
T
P
E
Q
A
Q
E
V
H
L
L
L
R
K
W
V
S
E
N
I
--
G
T
D
V
A
A
K
L
R
I
L
Y
G
G
S
V
N
A
A
N
A
A
T
L
Y
A
K
P
D
I
N
G
F
L
V
G
G
A
S
L
K
P
E
-
F
R
D
I
I
D
A
T
-
94
PsiBlast_CBE
72.94
40%
-110
- C6 -
-
2Y61
3
TPIS_LEIME
A:
[6-248]
---
Q
P
I
A
A
A
N
W
K
C
N
G
T
T
A
S
I
E
K
L
V
Q
V
F
-
N
E
-
H
T
--
I
S
H
--
D
-
V
Q
C
V
V
A
P
T
F
-
V
H
I
---
P
L
V
Q
A
K
--
L
R
N
P
K
Y
V
I
--
S
A
Q
N
A
-
I
A
K
S
G
A
F
T
G
E
V
S
M
P
I
L
K
D
I
G
V
H
W
V
I
L
G
H
S
E
R
R
T
Y
Y
G
E
T
D
E
I
V
A
Q
K
V
S
E
A
C
K
Q
G
F
M
V
I
A
C
I
G
E
T
L
Q
Q
R
E
A
N
Q
T
A
K
V
V
L
S
Q
T
S
A
I
A
A
K
L
T
K
D
A
W
N
Q
V
--
V
L
A
Y
E
P
V
W
A
I
G
T
G
K
V
A
T
P
E
Q
A
Q
E
V
H
L
L
L
R
K
W
V
S
E
N
I
--
G
T
D
V
A
A
K
L
R
I
L
Y
G
G
S
V
N
A
A
N
A
A
T
L
Y
A
K
P
D
I
N
G
F
L
V
G
G
A
S
L
K
P
E
-
F
R
D
I
I
D
---
155
Fugue
72.81
39%
-105
- C6 -
-
1IF2
1
TPIS_LEIME
A:
[3-251]
A
K
P
Q
P
I
A
A
A
N
W
K
C
N
G
T
T
A
S
I
E
K
L
V
Q
V
F
-
N
E
-
H
T
--
I
S
H
--
D
-
V
Q
C
V
V
A
P
T
F
-
V
H
I
---
P
L
V
Q
A
K
--
L
R
N
P
K
Y
V
I
--
S
A
Q
N
A
I
A
K
S
-
G
A
F
T
G
E
V
S
M
P
I
L
K
D
I
G
V
H
W
V
I
L
G
H
S
E
R
R
T
Y
Y
G
E
T
D
E
I
V
A
Q
K
V
S
E
A
C
K
Q
G
F
M
V
I
A
C
I
G
E
T
L
Q
Q
R
E
A
N
Q
T
A
K
V
V
L
S
Q
T
S
A
I
A
A
K
L
T
K
D
A
W
N
Q
V
--
V
L
A
Y
E
P
V
W
A
I
G
T
G
K
V
A
T
P
E
Q
A
Q
E
V
H
L
L
L
R
K
W
V
S
E
N
I
--
G
T
D
V
A
A
K
L
R
I
L
Y
G
G
S
V
N
A
A
N
A
A
T
L
Y
A
K
P
D
I
N
G
F
L
V
G
G
A
S
L
K
P
E
-
F
R
D
I
I
D
A
T
R
93
PsiBlast_CBE
72.57
40%
-112
- C6 -
-
2Y62
3
TPIS_LEIME
A:
[6-248]
---
Q
P
I
A
A
A
N
W
K
C
N
G
T
T
A
S
I
E
K
L
V
Q
V
F
-
N
E
-
H
T
--
I
S
H
--
D
-
V
Q
C
V
V
A
P
T
F
-
V
H
I
---
P
L
V
Q
A
K
--
L
R
N
P
K
Y
V
I
--
S
A
Q
N
A
-
I
A
K
S
G
A
F
T
G
E
V
S
M
P
I
L
K
D
I
G
V
H
W
V
I
L
G
H
S
E
R
R
T
Y
Y
G
E
T
D
E
I
V
A
Q
K
V
S
E
A
C
K
Q
G
F
M
V
I
A
C
I
G
E
T
L
Q
Q
R
E
A
N
Q
T
A
K
V
V
L
S
Q
T
S
A
I
A
A
K
L
T
K
D
A
W
N
Q
V
--
V
L
A
Y
E
P
V
W
A
I
G
T
G
K
V
A
T
P
E
Q
A
Q
E
V
H
L
L
L
R
K
W
V
S
E
N
I
--
G
T
D
V
A
A
K
L
R
I
L
Y
G
G
S
V
N
A
A
N
A
A
T
L
Y
A
K
P
D
I
N
G
F
L
V
G
G
A
S
L
K
P
E
-
F
R
D
I
I
D
---
92
PsiBlast_CBE
72.49
40%
-113
- C6 -
-
2Y63
1
TPIS_LEIME
A:
[6-248]
---
Q
P
I
A
A
A
N
W
K
C
N
G
T
T
A
S
I
E
K
L
V
Q
V
F
-
N
E
-
H
T
--
I
S
H
--
D
-
V
Q
C
V
V
A
P
T
F
-
V
H
I
---
P
L
V
Q
A
K
--
L
R
N
P
K
Y
V
I
--
S
A
Q
N
A
-
I
A
K
S
G
A
F
T
G
E
V
S
M
P
I
L
K
D
I
G
V
H
W
V
I
L
G
H
S
E
R
R
T
Y
Y
G
E
T
D
E
I
V
A
Q
K
V
S
E
A
C
K
Q
G
F
M
V
I
A
C
I
G
E
T
L
Q
Q
R
E
A
N
Q
T
A
K
V
V
L
S
Q
T
S
A
I
A
A
K
L
T
K
D
A
W
N
Q
V
--
V
L
A
Y
E
P
V
W
A
I
G
T
G
K
V
A
T
P
E
Q
A
Q
E
V
H
L
L
L
R
K
W
V
S
E
N
I
--
G
T
D
V
A
A
K
L
R
I
L
Y
G
G
S
V
N
A
A
N
A
A
T
L
Y
A
K
P
D
I
N
G
F
L
V
G
G
A
S
L
K
P
E
-
F
R
D
I
I
D
---
60
PsiBlast_CBE
72.48
42%
-115
- C6 -
-
4MVA
2
?
B:
[26-270]
--
R
H
P
L
V
M
G
N
W
K
L
N
G
S
R
H
M
V
H
E
L
V
S
N
L
-
R
K
-
E
L
--
A
G
V
--
A
G
C
A
V
A
I
A
P
P
E
-
M
Y
I
---
D
M
A
K
R
E
--
A
E
G
S
H
I
M
L
--
G
A
Q
N
V
D
L
N
L
S
G
A
F
T
G
E
T
S
A
A
M
L
K
D
I
G
A
Q
Y
I
I
I
G
H
S
E
R
R
T
Y
H
K
E
S
D
E
L
I
A
K
K
F
A
V
L
K
E
Q
G
L
T
P
V
L
C
I
G
E
T
E
A
E
N
E
A
G
K
T
E
E
V
C
A
R
Q
I
D
A
V
L
K
T
Q
G
A
A
A
F
E
G
A
--
V
I
A
Y
E
P
V
W
A
I
G
T
G
K
S
A
T
P
A
Q
A
Q
A
V
H
K
F
I
R
D
H
I
-
A
K
V
--
D
A
N
I
A
E
Q
V
I
I
Q
Y
G
G
S
V
N
A
S
N
A
A
E
L
F
A
Q
P
D
I
D
G
A
L
V
G
G
A
S
L
K
A
D
A
F
A
V
I
V
----
98
PsiBlast_CBE
72.44
40%
-109
- C6 -
-
1IF2
1
TPIS_LEIME
A:
[6-248]
---
Q
P
I
A
A
A
N
W
K
C
N
G
T
T
A
S
I
E
K
L
V
Q
V
F
-
N
E
-
H
T
--
I
S
H
--
D
-
V
Q
C
V
V
A
P
T
F
-
V
H
I
---
P
L
V
Q
A
K
--
L
R
N
P
K
Y
V
I
--
S
A
Q
N
A
-
I
A
K
S
G
A
F
T
G
E
V
S
M
P
I
L
K
D
I
G
V
H
W
V
I
L
G
H
S
E
R
R
T
Y
Y
G
E
T
D
E
I
V
A
Q
K
V
S
E
A
C
K
Q
G
F
M
V
I
A
C
I
G
E
T
L
Q
Q
R
E
A
N
Q
T
A
K
V
V
L
S
Q
T
S
A
I
A
A
K
L
T
K
D
A
W
N
Q
V
--
V
L
A
Y
E
P
V
W
A
I
G
T
G
K
V
A
T
P
E
Q
A
Q
E
V
H
L
L
L
R
K
W
V
S
E
N
I
--
G
T
D
V
A
A
K
L
R
I
L
Y
G
G
S
V
N
A
A
N
A
A
T
L
Y
A
K
P
D
I
N
G
F
L
V
G
G
A
S
L
K
P
E
-
F
R
D
I
I
D
---
97
PsiBlast_CBE
72.35
40%
-111
- C6 -
-
1N55
6
TPIS_LEIME
A:
[6-248]
---
Q
P
I
A
A
A
N
W
K
C
N
G
T
T
A
S
I
E
K
L
V
Q
V
F
-
N
E
-
H
T
--
I
S
H
--
D
-
V
Q
C
V
V
A
P
T
F
-
V
H
I
---
P
L
V
Q
A
K
--
L
R
N
P
K
Y
V
I
--
S
A
Q
N
A
-
I
A
K
S
G
A
F
T
G
E
V
S
M
P
I
L
K
D
I
G
V
H
W
V
I
L
G
H
S
E
R
R
T
Y
Y
G
E
T
D
E
I
V
A
Q
K
V
S
E
A
C
K
Q
G
F
M
V
I
A
C
I
G
E
T
L
Q
Q
R
E
A
N
Q
T
A
K
V
V
L
S
Q
T
S
A
I
A
A
K
L
T
K
D
A
W
N
Q
V
--
V
L
A
Y
E
P
V
W
A
I
G
T
G
K
V
A
T
P
E
Q
A
Q
E
V
H
L
L
L
R
K
W
V
S
E
N
I
--
G
T
D
V
A
A
K
L
R
I
L
Y
G
G
S
V
N
A
A
N
A
A
T
L
Y
A
K
P
D
I
N
G
F
L
V
G
G
A
S
L
K
P
E
-
F
R
D
I
I
D
---
96
PsiBlast_CBE
72.24
40%
-111
- C6 -
-
1QDS
1
TPIS_LEIME
A:
[6-248]
---
Q
P
I
A
A
A
N
W
K
C
N
G
T
T
A
S
I
E
K
L
V
Q
V
F
-
N
E
-
H
T
--
I
S
H
--
D
-
V
Q
C
V
V
A
P
T
F
-
V
H
I
---
P
L
V
Q
A
K
--
L
R
N
P
K
Y
V
I
--
S
A
Q
N
A
-
I
A
K
S
G
A
F
T
G
E
V
S
M
P
I
L
K
D
I
G
V
H
W
V
I
L
G
H
S
E
R
R
T
Y
Y
G
E
T
D
E
I
V
A
Q
K
V
S
E
A
C
K
Q
G
F
M
V
I
A
C
I
G
E
T
L
Q
Q
R
E
A
N
Q
T
A
K
V
V
L
S
Q
T
S
A
I
A
A
K
L
T
K
D
A
W
N
Q
V
--
V
L
A
Y
E
P
V
W
A
I
G
T
G
K
V
A
T
P
E
Q
A
Q
E
V
H
L
L
L
R
K
W
V
S
E
N
I
--
G
T
D
V
A
A
K
L
R
I
L
Y
G
G
S
V
N
A
A
N
A
A
T
L
Y
A
K
P
D
I
N
G
F
L
V
G
G
A
S
L
K
P
E
-
F
R
D
I
I
D
---
95
PsiBlast_CBE
72.03
40%
-111
- C6 -
-
2VXN
6
TPIS_LEIME
A:
[6-248]
---
Q
P
I
A
A
A
N
W
K
C
N
G
T
T
A
S
I
E
K
L
V
Q
V
F
-
N
E
-
H
T
--
I
S
H
--
D
-
V
Q
C
V
V
A
P
T
F
-
V
H
I
---
P
L
V
Q
A
K
--
L
R
N
P
K
Y
V
I
--
S
A
Q
N
A
-
I
A
K
S
G
A
F
T
G
E
V
S
M
P
I
L
K
D
I
G
V
H
W
V
I
L
G
H
S
E
R
R
T
Y
Y
G
E
T
D
E
I
V
A
Q
K
V
S
E
A
C
K
Q
G
F
M
V
I
A
C
I
G
E
T
L
Q
Q
R
E
A
N
Q
T
A
K
V
V
L
S
Q
T
S
A
I
A
A
K
L
T
K
D
A
W
N
Q
V
--
V
L
A
Y
E
P
V
W
A
I
G
T
G
K
V
A
T
P
E
Q
A
Q
E
V
H
L
L
L
R
K
W
V
S
E
N
I
--
G
T
D
V
A
A
K
L
R
I
L
Y
G
G
S
V
N
A
A
N
A
A
T
L
Y
A
K
P
D
I
N
G
F
L
V
G
G
A
S
L
K
P
E
-
F
R
D
I
I
D
---
103
PsiBlast_CBE
71.32
39%
-107
- C6 -
-
1AMK
1
TPIS_LEIME
A:
[6-248]
---
Q
P
I
A
A
A
N
W
K
C
N
G
T
T
A
S
I
E
K
L
V
Q
V
F
-
N
E
-
H
T
--
I
S
H
--
D
-
V
Q
C
V
V
A
P
T
F
-
V
H
I
---
P
L
V
Q
A
K
--
L
R
N
P
K
Y
V
I
--
S
A
E
N
A
-
I
A
K
S
G
A
F
T
G
E
V
S
M
P
I
L
K
D
I
G
V
H
W
V
I
L
G
H
S
E
R
R
T
Y
Y
G
E
T
D
E
I
V
A
Q
K
V
S
E
A
C
K
Q
G
F
M
V
I
A
C
I
G
E
T
L
Q
Q
R
E
A
N
Q
T
A
K
V
V
L
S
Q
T
S
A
I
A
A
K
L
T
K
D
A
W
N
Q
V
--
V
L
A
Y
E
P
V
W
A
I
G
T
G
K
V
A
T
P
E
Q
A
Q
E
V
H
L
L
L
R
K
W
V
S
E
N
I
--
G
T
D
V
A
A
K
L
R
I
L
Y
G
G
S
V
N
A
A
N
A
A
T
L
Y
A
K
P
D
I
N
G
F
L
V
G
G
A
S
L
K
P
E
-
F
R
D
I
I
D
---
137
HHSearch
70.38
39%
-101
- C6 -
-
3YPI
1
TPIS_YEAST
B:
[1-246]
-
A
R
T
F
F
V
G
G
N
F
K
L
N
G
S
K
Q
S
I
K
E
I
V
E
R
L
-
N
T
-
A
S
---
I
P
--
E
N
V
E
V
V
I
C
P
P
A
-
T
Y
L
---
D
Y
S
V
S
L
--
V
K
K
P
Q
V
T
V
--
G
A
Q
N
A
Y
L
K
A
S
G
A
F
T
G
E
N
S
V
D
Q
I
K
D
V
G
A
K
W
V
I
L
G
Q
S
E
R
R
S
Y
F
H
E
D
D
K
F
I
A
D
K
T
K
F
A
L
G
Q
G
V
G
V
I
L
C
I
G
E
T
L
E
E
K
K
A
G
K
T
L
D
V
V
E
R
Q
L
N
A
V
L
E
E
V
--
K
D
W
T
N
V
--
V
V
A
Y
E
P
V
W
A
I
G
T
G
L
A
A
T
P
E
D
A
Q
D
I
H
A
S
I
R
K
F
L
A
S
K
L
--
G
D
K
A
A
S
E
L
R
I
L
Y
G
G
S
A
N
G
S
N
A
V
T
F
K
D
K
A
D
V
D
G
F
L
V
G
G
A
S
L
K
P
E
-
F
V
D
I
I
N
S
R
-
148
HHSearch
70.14
36%
-100
- C6 -
-
1O5X
1
TPIS_PLAFA
B:
[3-247]
--
R
K
Y
F
V
A
A
N
W
K
C
N
G
T
L
E
S
I
K
S
L
T
N
S
F
-
N
N
-
L
D
--
F
D
P
--
S
K
L
D
V
V
V
F
P
V
S
-
V
H
Y
---
D
H
T
R
K
L
--
L
Q
-
S
K
F
S
T
--
G
I
Q
N
V
S
K
F
G
N
G
S
Y
T
G
E
V
S
A
E
I
A
K
D
L
N
I
E
Y
V
I
I
G
H
F
E
R
R
K
Y
F
H
E
T
D
E
D
V
R
E
K
L
Q
A
S
L
K
N
N
L
K
A
V
V
C
F
G
E
S
L
E
Q
R
E
Q
N
K
T
I
E
V
I
T
K
Q
V
K
A
F
V
D
L
I
--
D
N
F
D
N
V
--
I
L
V
Y
E
P
L
W
A
I
G
T
G
K
T
A
T
P
E
Q
A
Q
L
V
H
K
E
I
R
K
I
V
K
D
T
C
--
G
E
K
Q
A
N
Q
I
R
I
L
Y
G
G
-------
S
S
L
I
Q
Q
E
D
I
D
G
F
L
V
G
N
A
S
L
K
E
-
S
F
V
D
I
I
K
S
A
-
139
HHSearch
69.80
37%
-99
- C6 -
-
4Z0J
10
TPIS_PLAFA
B:
[2-247]
-
A
R
K
Y
F
V
A
A
N
W
K
C
N
G
T
L
E
S
I
K
S
L
T
N
S
F
-
N
N
-
L
D
--
F
D
P
--
S
K
L
D
V
V
V
F
P
V
S
-
V
H
Y
---
D
H
T
R
K
L
--
L
Q
-
S
K
F
S
T
--
G
I
Q
N
V
S
K
F
G
N
G
A
Y
T
G
E
V
S
A
E
I
A
K
D
L
N
I
E
Y
V
I
I
G
H
S
E
R
R
K
Y
F
H
E
T
D
E
D
V
R
E
K
L
Q
A
S
L
K
N
N
L
K
A
V
V
C
F
G
E
S
L
E
Q
R
E
Q
N
K
T
I
E
V
I
T
K
Q
V
K
A
F
V
D
L
I
--
D
N
F
D
N
V
--
I
L
V
Y
E
P
L
W
A
I
G
T
G
K
T
A
T
P
E
Q
A
Q
L
V
H
K
E
I
R
K
I
V
K
D
T
C
--
G
E
K
Q
A
N
Q
I
R
I
L
Y
G
G
S
------
S
S
L
I
Q
Q
E
D
I
D
G
F
L
V
G
N
A
S
L
K
E
-
S
F
V
D
I
I
K
S
A
-
79
PsiBlast_CBE
69.70
40%
1
- C6 -
-
4BI7
1
TPI1_GIAIN
A:
[3-252]
-
A
R
R
P
F
I
G
G
N
F
K
C
N
G
S
L
D
F
I
K
S
H
V
A
A
I
-
A
A
H
K
I
--
P
----
D
S
V
D
V
V
I
A
P
S
A
-
V
H
L
---
S
T
A
I
A
A
--
N
T
S
K
Q
L
R
I
--
A
A
Q
N
V
Y
L
E
G
N
G
A
W
T
G
E
T
S
V
E
M
L
Q
D
M
G
L
K
H
V
I
V
G
H
S
E
R
R
R
I
M
G
E
T
D
E
Q
S
A
K
K
A
K
R
A
L
E
K
G
M
T
V
I
F
C
V
G
E
T
L
D
E
R
K
A
N
R
T
M
E
V
N
I
A
Q
L
E
A
L
G
K
E
L
G
E
S
K
M
L
W
K
E
V
V
I
A
Y
E
P
V
W
S
I
G
T
G
V
V
A
T
P
E
Q
A
E
E
V
H
V
G
L
R
K
W
F
A
E
K
V
--
A
A
E
G
A
Q
H
I
R
I
I
Y
G
G
S
A
N
G
S
N
C
E
K
L
G
Q
C
P
N
I
D
G
F
L
V
G
G
A
S
L
K
P
E
-
F
M
T
M
I
D
I
L
-
81
PsiBlast_CBE
69.61
40%
2
- C6 -
-
4BI6
1
TPI1_GIAIN
A:
[3-252]
-
A
R
R
P
F
I
G
G
N
F
K
C
N
G
S
L
D
F
I
K
S
H
V
A
A
I
-
A
A
H
K
I
--
P
----
D
S
V
D
V
V
I
A
P
S
A
-
V
H
L
---
S
T
A
I
A
A
--
N
T
S
K
Q
L
R
I
--
A
A
Q
N
V
Y
L
E
G
N
G
A
W
T
G
E
T
S
V
E
M
L
Q
D
M
G
L
K
H
V
I
V
G
H
S
E
R
R
R
I
M
G
E
T
D
E
Q
S
A
K
K
A
K
R
A
L
E
K
G
M
T
V
I
F
C
V
G
E
T
L
D
E
R
K
A
N
R
T
M
E
V
N
I
A
Q
L
E
A
L
G
K
E
L
G
E
S
K
M
L
W
K
E
V
V
I
A
Y
E
P
V
W
S
I
G
T
G
V
V
A
T
P
E
Q
A
E
E
V
H
V
G
L
R
K
W
F
V
E
K
V
--
A
A
E
G
A
Q
H
I
R
I
I
Y
G
G
S
A
N
G
S
N
N
E
K
L
G
Q
C
P
N
I
D
G
F
L
V
G
G
A
S
L
K
P
E
-
F
M
T
M
I
D
I
L
-
43
PsiBlast_CBE
69.32
46%
-22
- C6 -
-
3GVG
2
TPIS_MYCTU
B:
[24-273]
-
S
R
K
P
L
I
A
G
N
W
K
M
N
L
N
H
Y
E
A
I
A
L
V
Q
K
I
-
A
F
-
S
L
--
P
D
K
YY
D
R
V
D
V
A
V
I
P
P
F
-
T
D
L
---
R
S
V
Q
T
L
--
V
D
G
D
K
L
R
L
TY
G
A
Q
D
L
S
P
H
D
S
G
A
Y
T
G
D
V
S
G
A
F
L
A
K
L
G
C
S
Y
V
V
V
G
H
S
E
R
R
T
Y
H
N
E
D
D
A
L
V
A
A
K
A
A
T
A
L
K
H
G
L
T
P
I
V
C
I
G
E
H
L
D
V
R
E
A
G
N
H
V
A
H
N
I
E
Q
L
R
G
S
L
A
G
L
L
A
E
Q
I
G
S
V
--
V
I
A
Y
E
P
V
W
A
I
G
T
G
R
V
A
S
A
A
D
A
Q
E
V
C
A
A
I
R
K
E
L
A
S
L
A
--
S
P
R
I
A
D
T
V
R
V
L
Y
G
G
S
V
N
A
K
N
V
G
D
I
V
A
Q
D
D
V
D
G
G
L
V
G
G
A
S
L
D
G
E
H
F
A
T
L
-----
69
PsiBlast_CBE
68.99
39%
-15
- C6 -
-
4YMZ
10
TPIS_LEPIN
A:
[2-251]
-
A
R
K
T
I
I
A
G
N
W
K
M
N
L
S
L
K
E
A
V
F
L
A
H
S
I
-
R
E
-
K
I
--
P
S
I
--
S
K
D
K
V
S
M
V
F
P
S
T
L
H
L
---
E
N
V
S
K
I
--
L
E
G
S
S
V
I
V
--
G
A
Q
N
C
Y
H
S
G
L
A
A
F
T
G
E
T
S
P
D
Q
L
K
E
I
G
V
K
V
V
M
V
G
H
S
E
R
R
Q
F
L
G
E
S
N
F
F
C
N
D
K
I
R
F
L
L
K
N
E
F
T
V
L
Y
C
V
G
E
T
L
S
E
R
E
S
G
K
T
L
E
V
L
S
S
Q
I
R
E
G
L
K
G
I
D
S
V
F
F
S
N
L
--
I
L
A
Y
E
P
V
W
A
I
G
T
G
K
V
A
T
P
S
Q
A
Q
E
V
H
S
F
I
R
K
E
I
S
G
L
F
VG
A
S
S
I
S
E
S
I
S
I
L
Y
G
G
S
V
K
P
D
N
I
Q
D
L
L
K
E
K
D
I
D
G
G
L
V
G
G
A
S
Q
K
I
S
S
F
A
G
L
F
----
19
PsiBlast_PDB
68.91
46%
-20
- C6 -
-
3GVG
1
TPIS_MYCTU
A:
[24-273]
-
S
R
K
P
L
I
A
G
N
W
K
M
N
L
N
H
Y
E
A
I
A
L
V
Q
K
I
-
A
F
-
S
L
--
P
D
K
Y
Y
D
R
V
D
V
A
V
I
P
P
F
-
T
D
L
---
R
S
V
Q
T
L
--
V
D
G
D
K
L
R
L
T
Y
G
A
Q
D
L
S
P
H
D
S
G
A
Y
T
G
D
V
S
G
A
F
L
A
K
L
G
C
S
Y
V
V
V
G
H
S
E
R
R
T
Y
H
N
E
D
D
A
L
V
A
A
K
A
A
T
A
L
K
H
G
L
T
P
I
V
C
I
G
E
H
L
D
V
R
E
A
G
N
H
V
A
H
N
I
E
Q
L
R
G
S
L
A
G
L
L
A
E
Q
I
G
S
V
--
V
I
A
Y
E
P
V
W
A
I
G
T
G
R
V
A
S
A
A
D
A
Q
E
V
C
A
A
I
R
K
E
L
A
S
L
A
--
S
P
R
I
A
D
T
V
R
V
L
Y
G
G
S
V
N
A
K
N
V
G
D
I
V
A
Q
D
D
V
D
G
G
L
V
G
G
A
S
L
D
G
E
H
F
A
T
L
-----
68
PsiBlast_CBE
68.70
39%
-17
- C6 -
-
4YMZ
8
TPIS_LEPIN
B:
[2-251]
-
A
R
K
T
I
I
A
G
N
W
K
M
N
L
S
L
K
E
A
V
F
L
A
H
S
I
-
R
E
-
K
I
--
P
S
I
--
S
K
D
K
V
S
M
V
F
P
S
T
L
H
L
---
E
N
V
S
K
I
--
L
E
G
S
S
V
I
V
--
G
A
Q
N
C
Y
H
S
G
L
A
A
F
T
G
E
T
S
P
D
Q
L
K
E
I
G
V
K
V
V
M
V
G
H
S
E
R
R
Q
F
L
G
E
S
N
F
F
C
N
D
K
I
R
F
L
L
K
N
E
F
T
V
L
Y
C
V
G
E
T
L
S
E
R
E
S
G
K
T
L
E
V
L
S
S
Q
I
R
E
G
L
K
G
I
D
S
V
F
F
S
N
L
--
I
L
A
Y
E
P
V
W
A
I
G
T
G
K
V
A
T
P
S
Q
A
Q
E
V
H
S
F
I
R
K
E
I
S
G
L
F
VG
A
S
S
I
S
E
S
I
S
I
L
Y
G
G
S
V
K
P
D
N
I
Q
D
L
L
K
E
K
D
I
D
G
G
L
V
G
G
A
S
Q
K
I
S
S
F
A
G
L
F
----
18
PsiBlast_PDB
67.73
46%
-16
- C6 -
-
3TAO
2
TPIS_MYCTU
A:
[2-251]
-
S
R
K
P
L
I
A
G
N
W
K
M
N
L
N
H
Y
E
A
I
A
L
V
Q
K
I
-
A
F
-
S
L
--
P
D
K
Y
Y
D
R
V
D
V
A
V
I
P
P
F
-
T
D
L
---
R
S
V
Q
T
L
--
V
D
G
D
K
L
R
L
T
Y
G
A
Q
D
L
S
P
H
D
S
G
A
Y
T
G
D
V
S
G
A
F
L
A
K
L
G
C
S
Y
V
V
V
G
H
S
E
R
R
T
Y
H
N
E
D
D
A
L
V
A
A
K
A
A
T
A
L
K
H
G
L
T
P
I
V
C
I
G
E
H
L
D
V
R
E
A
G
N
H
V
A
H
N
I
E
Q
L
R
G
S
L
A
G
L
L
A
E
Q
I
G
S
V
--
V
I
A
Y
E
P
V
W
A
I
G
T
G
R
V
A
S
A
A
D
A
Q
E
V
C
A
A
I
R
K
E
L
A
S
L
A
--
S
P
R
I
A
D
T
V
R
V
L
Y
G
G
S
V
N
A
K
N
V
G
D
I
V
A
Q
D
D
V
D
G
G
L
V
G
G
A
S
L
D
G
E
H
F
A
T
L
-----
82
PsiBlast_CBE
63.36
40%
-9
- C6 -
-
7TIM
1
TPIS_YEAST
B:
[1-238]
-
A
R
T
F
F
V
G
G
N
F
K
L
N
G
S
K
Q
S
I
K
E
I
V
E
R
L
N
T
A
-
S
I
--
P
E
N
----
V
E
V
V
I
C
P
P
A
-
T
Y
L
---
D
Y
S
V
S
L
--
V
K
K
P
Q
V
T
V
--
G
A
Q
N
A
Y
L
K
A
S
G
A
F
T
G
E
N
S
V
D
Q
I
K
D
V
G
A
K
W
V
I
L
G
H
S
E
R
R
S
Y
F
H
E
D
D
K
F
I
A
D
K
T
K
F
A
L
G
Q
G
V
G
V
I
L
C
I
G
E
T
L
E
E
K
K
A
G
K
T
L
D
V
V
E
R
Q
L
N
A
V
L
E
--
E
V
K
D
W
T
N
V
--
V
V
A
Y
E
P
V
W
A
I
G
T
G
L
A
A
T
P
E
D
A
Q
D
I
H
A
S
I
R
K
F
L
A
S
K
L
--
G
D
K
A
A
S
E
L
R
I
L
Y
G
G
S
A
N
G
S
N
A
V
T
F
K
D
K
A
D
V
D
G
F
L
V
G
G
A
S
L
K
P
E
----------
87
PsiBlast_CBE
62.95
39%
-6
- C6 -
-
4FF7
8
TPIS_YEAST
A:
[2-239]
-
A
R
T
F
F
V
G
G
N
F
K
L
N
G
S
K
Q
S
I
K
E
I
V
E
R
L
N
T
A
-
S
I
--
P
E
N
----
V
E
V
V
I
C
P
P
A
-
T
Y
L
---
D
Y
S
V
S
L
--
V
K
K
P
Q
V
T
V
--
G
A
Q
N
A
Y
L
K
A
S
G
A
F
T
G
E
N
S
V
D
Q
I
K
D
V
G
A
K
W
V
I
L
G
H
S
E
R
R
S
Y
F
H
E
D
D
K
F
I
A
D
K
T
K
F
A
L
G
Q
G
V
G
V
I
L
S
I
G
E
T
L
E
E
K
K
A
G
K
T
L
D
V
V
E
R
Q
L
N
A
V
L
E
--
E
V
K
D
W
T
N
V
--
V
V
A
Y
E
P
V
W
A
I
G
T
G
L
A
A
T
P
E
D
A
Q
D
I
H
A
S
I
R
K
F
L
A
S
K
L
--
G
D
K
A
A
S
E
L
R
I
L
Y
G
G
S
A
N
G
S
N
A
V
T
F
K
D
K
A
D
V
D
G
F
L
V
G
G
A
S
L
K
P
E
----------
85
PsiBlast_CBE
62.73
40%
-8
- C6 -
-
2YPI
1
TPIS_YEAST
A:
[1-238]
-
A
R
T
F
F
V
G
G
N
F
K
L
N
G
S
K
Q
S
I
K
E
I
V
E
R
L
N
T
A
-
S
I
--
P
E
N
----
V
E
V
V
I
C
P
P
A
-
T
Y
L
---
D
Y
S
V
S
L
--
V
K
K
P
Q
V
T
V
--
G
A
Q
N
A
Y
L
K
A
S
G
A
F
T
G
E
N
S
V
D
Q
I
K
D
V
G
A
K
W
V
I
L
G
H
S
E
R
R
S
Y
F
H
E
D
D
K
F
I
A
D
K
T
K
F
A
L
G
Q
G
V
G
V
I
L
C
I
G
E
T
L
E
E
K
K
A
G
K
T
L
D
V
V
E
R
Q
L
N
A
V
L
E
--
E
V
K
D
W
T
N
V
--
V
V
A
Y
E
P
V
W
A
I
G
T
G
L
A
A
T
P
E
D
A
Q
D
I
H
A
S
I
R
K
F
L
A
S
K
L
--
G
D
K
A
A
S
E
L
R
I
L
Y
G
G
S
A
N
G
S
N
A
V
T
F
K
D
K
A
D
V
D
G
F
L
V
G
G
A
S
L
K
P
E
----------
83
PsiBlast_CBE
62.65
40%
-7
- C6 -
-
7TIM
1
TPIS_YEAST
A:
[1-238]
-
A
R
T
F
F
V
G
G
N
F
K
L
N
G
S
K
Q
S
I
K
E
I
V
E
R
L
N
T
A
-
S
I
--
P
E
N
----
V
E
V
V
I
C
P
P
A
-
T
Y
L
---
D
Y
S
V
S
L
--
V
K
K
P
Q
V
T
V
--
G
A
Q
N
A
Y
L
K
A
S
G
A
F
T
G
E
N
S
V
D
Q
I
K
D
V
G
A
K
W
V
I
L
G
H
S
E
R
R
S
Y
F
H
E
D
D
K
F
I
A
D
K
T
K
F
A
L
G
Q
G
V
G
V
I
L
C
I
G
E
T
L
E
E
K
K
A
G
K
T
L
D
V
V
E
R
Q
L
N
A
V
L
E
--
E
V
K
D
W
T
N
V
--
V
V
A
Y
E
P
V
W
A
I
G
T
G
L
A
A
T
P
E
D
A
Q
D
I
H
A
S
I
R
K
F
L
A
S
K
L
--
G
D
K
A
A
S
E
L
R
I
L
Y
G
G
S
A
N
G
S
N
A
V
T
F
K
D
K
A
D
V
D
G
F
L
V
G
G
A
S
L
K
P
E
----------
86
PsiBlast_CBE
62.55
39%
-3
- C6 -
-
4FF7
8
TPIS_YEAST
B:
[2-239]
-
A
R
T
F
F
V
G
G
N
F
K
L
N
G
S
K
Q
S
I
K
E
I
V
E
R
L
N
T
A
-
S
I
--
P
E
N
----
V
E
V
V
I
C
P
P
A
-
T
Y
L
---
D
Y
S
V
S
L
--
V
K
K
P
Q
V
T
V
--
G
A
Q
N
A
Y
L
K
A
S
G
A
F
T
G
E
N
S
V
D
Q
I
K
D
V
G
A
K
W
V
I
L
G
H
S
E
R
R
S
Y
F
H
E
D
D
K
F
I
A
D
K
T
K
F
A
L
G
Q
G
V
G
V
I
L
S
I
G
E
T
L
E
E
K
K
A
G
K
T
L
D
V
V
E
R
Q
L
N
A
V
L
E
--
E
V
K
D
W
T
N
V
--
V
V
A
Y
E
P
V
W
A
I
G
T
G
L
A
A
T
P
E
D
A
Q
D
I
H
A
S
I
R
K
F
L
A
S
K
L
--
G
D
K
A
A
S
E
L
R
I
L
Y
G
G
S
A
N
G
S
N
A
V
T
F
K
D
K
A
D
V
D
G
F
L
V
G
G
A
S
L
K
P
E
----------
104
PsiBlast_CBE
61.59
39%
-5
- C6 -
-
3YPI
1
TPIS_YEAST
B:
[1-238]
-
A
R
T
F
F
V
G
G
N
F
K
L
N
G
S
K
Q
S
I
K
E
I
V
E
R
L
N
T
A
-
S
I
--
P
E
N
----
V
E
V
V
I
C
P
P
A
-
T
Y
L
---
D
Y
S
V
S
L
--
V
K
K
P
Q
V
T
V
--
G
A
Q
N
A
Y
L
K
A
S
G
A
F
T
G
E
N
S
V
D
Q
I
K
D
V
G
A
K
W
V
I
L
G
Q
S
E
R
R
S
Y
F
H
E
D
D
K
F
I
A
D
K
T
K
F
A
L
G
Q
G
V
G
V
I
L
C
I
G
E
T
L
E
E
K
K
A
G
K
T
L
D
V
V
E
R
Q
L
N
A
V
L
E
--
E
V
K
D
W
T
N
V
--
V
V
A
Y
E
P
V
W
A
I
G
T
G
L
A
A
T
P
E
D
A
Q
D
I
H
A
S
I
R
K
F
L
A
S
K
L
--
G
D
K
A
A
S
E
L
R
I
L
Y
G
G
S
A
N
G
S
N
A
V
T
F
K
D
K
A
D
V
D
G
F
L
V
G
G
A
S
L
K
P
E
----------
105
PsiBlast_CBE
61.20
39%
-8
- C6 -
-
3YPI
1
TPIS_YEAST
A:
[1-238]
-
A
R
T
F
F
V
G
G
N
F
K
L
N
G
S
K
Q
S
I
K
E
I
V
E
R
L
N
T
A
-
S
I
--
P
E
N
----
V
E
V
V
I
C
P
P
A
-
T
Y
L
---
D
Y
S
V
S
L
--
V
K
K
P
Q
V
T
V
--
G
A
Q
N
A
Y
L
K
A
S
G
A
F
T
G
E
N
S
V
D
Q
I
K
D
V
G
A
K
W
V
I
L
G
Q
S
E
R
R
S
Y
F
H
E
D
D
K
F
I
A
D
K
T
K
F
A
L
G
Q
G
V
G
V
I
L
C
I
G
E
T
L
E
E
K
K
A
G
K
T
L
D
V
V
E
R
Q
L
N
A
V
L
E
--
E
V
K
D
W
T
N
V
--
V
V
A
Y
E
P
V
W
A
I
G
T
G
L
A
A
T
P
E
D
A
Q
D
I
H
A
S
I
R
K
F
L
A
S
K
L
--
G
D
K
A
A
S
E
L
R
I
L
Y
G
G
S
A
N
G
S
N
A
V
T
F
K
D
K
A
D
V
D
G
F
L
V
G
G
A
S
L
K
P
E
----------
129
PsiBlast_CBE
61.00
38%
7
- C6 -
-
4ZZ9
3
TPIS_PLAFA
A:
[3-244]
--
R
K
Y
F
V
A
A
N
W
K
C
N
G
T
L
E
S
I
K
S
L
T
N
S
F
-
N
N
-
L
D
F
D
P
S
K
--
L
D
V
V
V
F
P
V
S
V
H
-
Y
D
H
---
T
R
K
L
L
Q
--
S
K
F
S
---
T
--
G
I
Q
N
V
S
K
F
G
N
G
S
Y
S
G
E
V
S
A
E
I
A
K
D
L
N
I
E
Y
V
I
I
G
H
F
E
R
R
K
Y
F
H
E
T
D
E
D
V
R
E
K
L
Q
A
S
L
K
N
N
L
K
A
V
V
C
F
G
E
S
L
E
Q
R
E
Q
N
K
T
I
E
V
I
T
K
Q
V
K
A
F
V
D
L
I
--
D
N
F
D
N
V
--
I
L
V
Y
E
P
L
W
A
I
G
T
---
A
T
P
E
Q
A
Q
L
V
H
K
E
I
R
K
I
V
K
D
T
C
--
G
E
K
Q
A
N
Q
I
R
I
L
Y
G
G
S
V
N
T
E
N
C
S
S
L
I
Q
Q
E
D
I
D
G
F
L
V
G
N
A
S
L
K
-
E
S
F
V
D
I
I
----
123
PsiBlast_CBE
60.65
38%
10
- C6 -
-
2VFH
1
TPIS_PLAFA
B:
[2-244]
-
A
R
K
Y
F
V
A
A
N
W
K
C
N
G
T
L
E
S
I
K
S
L
T
N
S
F
-
N
N
-
L
D
FD
P
S
K
--
L
D
V
V
V
F
P
V
S
V
H
-
Y
D
H
---
T
R
K
L
L
Q
--
S
K
F
S
---
T
--
G
I
Q
N
V
S
K
F
G
N
G
S
Y
T
G
E
V
S
A
E
I
A
K
D
L
N
I
E
Y
V
I
I
G
H
W
E
R
R
K
Y
F
H
E
T
D
E
D
V
R
E
K
L
Q
A
S
L
K
N
N
L
K
A
V
V
C
F
G
E
S
L
E
Q
R
E
Q
N
K
T
I
E
V
I
T
K
Q
V
K
A
F
V
D
L
I
--
D
N
F
D
N
V
--
I
L
V
Y
E
P
L
W
A
I
G
T
G
K
T
A
T
P
E
Q
A
Q
L
V
H
K
E
I
R
K
I
V
K
D
T
C
--
G
E
K
Q
A
N
Q
I
R
I
L
Y
G
G
S
V
N
T
E
N
C
S
S
L
I
Q
Q
E
D
I
D
G
F
L
V
G
N
A
S
L
K
-
E
S
F
V
D
I
I
----
127
PsiBlast_CBE
60.60
38%
8
- C6 -
-
3PSV
1
TPIS_PLAFA
A:
[3-244]
--
R
K
Y
F
V
A
A
N
W
K
C
N
G
T
L
E
S
I
K
S
L
T
N
S
F
-
N
N
-
L
D
F
D
P
S
K
--
L
D
V
V
V
F
P
V
S
V
H
-
Y
D
H
---
T
R
K
L
L
Q
--
S
K
F
S
---
T
--
G
I
Q
N
V
S
K
F
G
N
G
S
Y
T
G
E
V
S
A
E
I
A
K
D
L
N
I
E
Y
V
I
I
G
H
F
D
R
R
K
Y
F
H
E
T
D
E
D
V
R
E
K
L
Q
A
S
L
K
N
N
L
K
A
V
V
C
F
G
E
S
L
E
Q
R
E
Q
N
K
T
I
E
V
I
T
K
Q
V
K
A
F
V
D
L
I
--
D
N
F
D
N
V
--
I
L
V
Y
E
P
L
W
A
I
G
T
---
A
T
P
E
Q
A
Q
L
V
H
K
E
I
R
K
I
V
K
D
T
C
--
G
E
K
Q
A
N
Q
I
R
I
L
Y
G
G
S
V
N
T
E
N
C
S
S
L
I
Q
Q
E
D
I
D
G
F
L
V
G
N
A
S
L
K
-
E
S
F
V
D
I
I
----
126
PsiBlast_CBE
60.36
38%
9
- C6 -
-
3PSW
1
TPIS_PLAFA
A:
[3-244]
--
R
K
Y
F
V
A
A
N
W
K
C
N
G
T
L
E
S
I
K
S
L
T
N
S
F
-
N
N
-
L
D
F
D
P
S
K
--
L
D
V
V
V
F
P
V
S
V
H
-
Y
D
H
---
T
R
K
L
L
Q
--
S
K
F
S
---
T
--
G
I
Q
N
V
S
K
F
G
N
G
S
Y
T
G
E
V
S
A
E
I
A
K
D
L
N
I
E
Y
V
I
I
G
H
F
Q
R
R
K
Y
F
H
E
T
D
E
D
V
R
E
K
L
Q
A
S
L
K
N
N
L
K
A
V
V
C
F
G
E
S
L
E
Q
R
E
Q
N
K
T
I
E
V
I
T
K
Q
V
K
A
F
V
D
L
I
--
D
N
F
D
N
V
--
I
L
V
Y
E
P
L
W
A
I
G
T
G
K
T
A
T
P
E
Q
A
Q
L
V
H
K
E
I
R
K
I
V
K
D
T
C
--
G
E
K
Q
A
N
Q
I
R
I
L
Y
G
G
S
V
N
T
E
N
C
S
S
L
I
Q
Q
E
D
I
D
G
F
L
V
G
N
A
S
L
K
-
E
S
F
V
D
I
I
----
84
PsiBlast_CBE
60.32
40%
-0
- C6 -
-
2YPI
1
TPIS_YEAST
B:
[1-238]
-
A
R
T
F
F
V
G
G
N
F
K
L
N
G
S
K
Q
S
I
K
E
I
V
E
R
L
N
T
A
-
S
I
--
P
E
N
----
V
E
V
V
I
C
P
P
A
-
T
Y
L
---
D
Y
S
V
S
L
--
V
K
K
P
Q
V
T
V
--
G
A
Q
N
A
Y
L
K
A
S
G
A
F
T
G
E
N
S
V
D
Q
I
K
D
V
G
A
K
W
V
I
L
G
H
S
E
R
R
S
Y
F
H
E
D
D
K
F
I
A
D
K
T
K
F
A
L
G
Q
G
V
G
V
I
L
C
I
G
E
T
L
E
E
K
K
A
G
K
T
L
D
V
V
E
R
Q
L
N
A
V
L
E
--
E
V
K
D
W
T
N
V
--
V
V
A
Y
E
P
V
W
A
I
G
T
G
L
A
A
T
P
E
D
A
Q
D
I
H
A
S
I
R
K
F
L
A
S
K
L
--
G
D
K
A
A
S
E
L
R
I
L
Y
G
G
S
A
N
G
S
N
A
V
T
F
K
D
K
A
D
V
D
G
F
L
V
G
G
A
S
L
K
P
E
----------
128
PsiBlast_CBE
60.29
38%
9
- C6 -
-
4ZZ9
2
TPIS_PLAFA
B:
[2-244]
-
A
R
K
Y
F
V
A
A
N
W
K
C
N
G
T
L
E
S
I
K
S
L
T
N
S
F
-
N
N
-
L
D
F
D
P
S
K
--
L
D
V
V
V
F
P
V
S
V
H
-
Y
D
H
---
T
R
K
L
L
Q
--
S
K
F
S
---
T
--
G
I
Q
N
V
S
K
F
G
N
G
S
Y
S
G
E
V
S
A
E
I
A
K
D
L
N
I
E
Y
V
I
I
G
H
F
E
R
R
K
Y
F
H
E
T
D
E
D
V
R
E
K
L
Q
A
S
L
K
N
N
L
K
A
V
V
C
F
G
E
S
L
E
Q
R
E
Q
N
K
T
I
E
V
I
T
K
Q
V
K
A
F
V
D
L
I
--
D
N
F
D
N
V
--
I
L
V
Y
E
P
L
W
A
I
G
T
G
K
T
A
T
P
E
Q
A
Q
L
V
H
K
E
I
R
K
I
V
K
D
T
C
--
G
E
K
Q
A
N
Q
I
R
I
L
Y
G
G
S
V
N
T
E
N
C
S
S
L
I
Q
Q
E
D
I
D
G
F
L
V
G
N
A
S
L
K
-
E
S
F
V
D
I
I
----
112
PsiBlast_CBE
60.17
38%
14
- C6 -
-
2VFI
3
TPIS_PLAFA
B:
[3-244]
--
R
K
Y
F
V
A
A
N
W
K
C
N
G
T
L
E
S
I
K
S
L
T
N
S
F
-
N
N
-
L
D
FD
P
S
K
--
L
D
V
V
V
F
P
V
S
V
H
-
Y
D
H
---
T
R
K
L
L
Q
--
S
K
F
S
---
T
--
G
I
Q
N
V
S
K
F
G
N
G
S
Y
T
G
E
V
S
A
E
I
A
K
D
L
N
I
E
Y
V
I
I
G
H
F
E
R
R
K
Y
F
H
E
T
D
E
D
V
R
E
K
L
Q
A
S
L
K
N
N
L
K
A
V
V
C
F
G
E
S
L
E
Q
R
E
Q
N
K
T
I
E
V
I
T
K
Q
V
K
A
F
V
D
L
I
--
D
N
F
D
N
V
--
I
L
V
Y
E
P
L
W
A
I
G
T
G
K
T
A
T
P
E
Q
A
Q
L
V
H
K
E
I
R
K
I
V
K
D
T
C
--
G
E
K
Q
A
N
Q
I
R
I
L
Y
G
G
S
V
N
T
E
N
C
S
S
L
I
Q
Q
E
D
I
D
G
F
L
V
G
N
A
S
L
K
-
E
S
F
V
D
I
I
----
114
PsiBlast_CBE
60.10
38%
5
- C6 -
-
1O5X
1
TPIS_PLAFA
B:
[3-244]
--
R
K
Y
F
V
A
A
N
W
K
C
N
G
T
L
E
S
I
K
S
L
T
N
S
F
-
N
N
-
L
D
FD
P
S
K
--
L
D
V
V
V
F
P
V
S
V
H
-
Y
D
H
---
T
R
K
L
L
Q
--
S
K
F
S
---
T
--
G
I
Q
N
V
S
K
F
G
N
G
S
Y
T
G
E
V
S
A
E
I
A
K
D
L
N
I
E
Y
V
I
I
G
H
F
E
R
R
K
Y
F
H
E
T
D
E
D
V
R
E
K
L
Q
A
S
L
K
N
N
L
K
A
V
V
C
F
G
E
S
L
E
Q
R
E
Q
N
K
T
I
E
V
I
T
K
Q
V
K
A
F
V
D
L
I
--
D
N
F
D
N
V
--
I
L
V
Y
E
P
L
W
A
I
G
T
G
K
T
A
T
P
E
Q
A
Q
L
V
H
K
E
I
R
K
I
V
K
D
T
C
--
G
E
K
Q
A
N
Q
I
R
I
L
Y
G
G
-------
S
S
L
I
Q
Q
E
D
I
D
G
F
L
V
G
N
A
S
L
K
-
E
S
F
V
D
I
I
----
100
PsiBlast_CBE
59.96
39%
12
- C6 -
-
2VFE
3
TPIS_PLAFA
A:
[2-244]
-
A
R
K
Y
F
V
A
A
N
W
K
C
N
G
T
L
E
S
I
K
S
L
T
N
S
F
-
N
N
-
L
D
F
D
P
S
K
--
L
D
V
V
V
F
P
V
S
V
H
-
Y
D
H
---
T
R
K
L
L
Q
--
S
K
F
S
---
T
--
G
I
Q
N
V
S
K
F
G
N
G
S
Y
T
G
E
V
S
A
E
I
A
K
D
L
N
I
E
Y
V
I
I
G
H
S
E
R
R
K
Y
F
H
E
T
D
E
D
V
R
E
K
L
Q
A
S
L
K
N
N
L
K
A
V
V
C
F
G
E
S
L
E
Q
R
E
Q
N
K
T
I
E
V
I
T
K
Q
V
K
A
F
V
D
L
I
--
D
N
F
D
N
V
--
I
L
V
Y
E
P
L
W
A
I
G
T
G
K
T
A
T
P
E
Q
A
Q
L
V
H
K
E
I
R
K
I
V
K
D
T
C
--
G
E
K
Q
A
N
Q
I
R
I
L
Y
G
G
S
V
N
T
E
N
C
S
S
L
I
Q
Q
E
D
I
D
G
F
L
V
G
N
A
S
L
K
-
E
S
F
V
D
I
I
----
90
PsiBlast_CBE
59.96
39%
16
- C6 -
-
4YWI
5
TPIS_PLAFA
B:
[2-244]
-
A
R
K
Y
F
V
A
A
N
W
K
C
N
G
T
L
E
S
I
K
S
L
T
N
S
F
-
N
N
-
L
D
F
D
P
S
K
--
L
D
V
V
V
F
P
V
S
V
H
-
Y
D
H
---
T
R
K
L
L
Q
--
S
K
F
S
---
T
--
G
I
Q
N
V
S
K
F
G
N
G
S
Y
T
G
E
V
S
A
E
I
A
K
D
L
N
I
E
Y
V
I
I
G
H
S
E
R
R
K
Y
F
H
E
T
D
E
D
V
R
E
K
L
Q
A
S
L
K
N
N
L
K
A
V
V
C
F
G
E
S
L
E
Q
R
E
Q
N
K
T
I
E
V
I
T
K
Q
V
K
A
F
V
D
L
I
--
D
N
F
D
N
V
--
I
L
V
Y
E
P
V
W
A
I
G
--
K
T
A
T
P
E
Q
A
Q
L
V
H
K
E
I
R
K
I
V
K
D
T
C
--
G
E
K
Q
A
N
Q
I
R
I
L
Y
G
G
S
V
N
T
E
N
C
S
S
L
I
Q
Q
E
D
I
D
G
F
L
V
G
N
A
S
L
K
-
E
S
F
V
D
I
I
----
124
PsiBlast_CBE
59.73
38%
15
- C6 -
-
2VFH
1
TPIS_PLAFA
A:
[2-244]
-
A
R
K
Y
F
V
A
A
N
W
K
C
N
G
T
L
E
S
I
K
S
L
T
N
S
F
-
N
N
-
L
D
F
D
P
S
K
--
L
D
V
V
V
F
P
V
S
V
H
-
Y
D
H
---
T
R
K
L
L
Q
--
S
K
F
S
---
T
--
G
I
Q
N
V
S
K
F
G
N
G
S
Y
T
G
E
V
S
A
E
I
A
K
D
L
N
I
E
Y
V
I
I
G
H
W
E
R
R
K
Y
F
H
E
T
D
E
D
V
R
E
K
L
Q
A
S
L
K
N
N
L
K
A
V
V
C
F
G
E
S
L
E
Q
R
E
Q
N
K
T
I
E
V
I
T
K
Q
V
K
A
F
V
D
L
I
--
D
N
F
D
N
V
--
I
L
V
Y
E
P
L
W
A
I
G
T
G
K
T
A
T
P
E
Q
A
Q
L
V
H
K
E
I
R
K
I
V
K
D
T
C
--
G
E
K
Q
A
N
Q
I
R
I
L
Y
G
G
S
V
N
T
E
N
C
S
S
L
I
Q
Q
E
D
I
D
G
F
L
V
G
N
A
S
L
K
-
E
S
F
V
D
I
I
----
125
PsiBlast_CBE
59.72
38%
2
- C6 -
-
3PSW
2
TPIS_PLAFA
B:
[3-244]
--
R
K
Y
F
V
A
A
N
W
K
C
N
G
T
L
E
S
I
K
S
L
T
N
S
F
-
N
N
-
L
D
FD
P
S
K
--
L
D
V
V
V
F
P
V
S
V
H
-
Y
D
H
---
T
R
K
L
L
Q
--
S
K
F
S
---
T
--
G
I
Q
N
V
S
K
F
G
N
G
S
Y
T
G
E
V
S
A
E
I
A
K
D
L
N
I
E
Y
V
I
I
G
H
F
Q
R
R
K
Y
F
H
E
T
D
E
D
V
R
E
K
L
Q
A
S
L
K
N
N
L
K
A
V
V
C
F
G
E
S
L
E
Q
R
E
Q
N
K
T
I
E
V
I
T
K
Q
V
K
A
F
V
D
L
I
--
D
N
F
D
N
V
--
I
L
V
Y
E
P
L
W
A
I
G
T
G
K
T
A
T
P
E
Q
A
Q
L
V
H
K
E
I
R
K
I
V
K
D
T
C
--
G
E
K
Q
A
N
Q
I
R
I
L
Y
G
G
S
------
S
S
L
I
Q
Q
E
D
I
D
G
F
L
V
G
N
A
S
L
K
-
E
S
F
V
D
I
I
----
115
PsiBlast_CBE
59.71
38%
9
- C6 -
-
1O5X
1
TPIS_PLAFA
A:
[3-244]
--
R
K
Y
F
V
A
A
N
W
K
C
N
G
T
L
E
S
I
K
S
L
T
N
S
F
-
N
N
-
L
D
F
D
P
S
K
--
L
D
V
V
V
F
P
V
S
V
H
-
Y
D
H
---
T
R
K
L
L
Q
--
S
K
F
S
---
T
--
G
I
Q
N
V
S
K
F
G
N
G
S
Y
T
G
E
V
S
A
E
I
A
K
D
L
N
I
E
Y
V
I
I
G
H
F
E
R
R
K
Y
F
H
E
T
D
E
D
V
R
E
K
L
Q
A
S
L
K
N
N
L
K
A
V
V
C
F
G
E
S
L
E
Q
R
E
Q
N
K
T
I
E
V
I
T
K
Q
V
K
A
F
V
D
L
I
--
D
N
F
D
N
V
--
I
L
V
Y
E
P
L
W
A
I
G
T
G
K
T
A
T
P
E
Q
A
Q
L
V
H
K
E
I
R
K
I
V
K
D
T
C
--
G
E
K
Q
A
N
Q
I
R
I
L
Y
G
G
S
V
N
T
E
N
C
S
S
L
I
Q
Q
E
D
I
D
G
F
L
V
G
N
A
S
L
K
-
E
S
F
V
D
I
I
----
117
PsiBlast_CBE
59.66
38%
10
- C6 -
-
1M7P
1
TPIS_PLAFA
A:
[3-244]
--
R
K
Y
F
V
A
A
N
W
K
C
N
G
T
L
E
S
I
K
S
L
T
N
S
F
-
N
N
-
L
D
F
D
P
S
K
--
L
D
V
V
V
F
P
V
S
V
H
-
Y
D
H
---
T
R
K
L
L
Q
--
S
K
F
S
---
T
--
G
I
Q
N
V
S
K
F
G
N
G
S
Y
T
G
E
V
S
A
E
I
A
K
D
L
N
I
E
Y
V
I
I
G
H
F
E
R
R
K
Y
F
H
E
T
D
E
D
V
R
E
K
L
Q
A
S
L
K
N
N
L
K
A
V
V
C
F
G
E
S
L
E
Q
R
E
Q
N
K
T
I
E
V
I
T
K
Q
V
K
A
F
V
D
L
I
--
D
N
F
D
N
V
--
I
L
V
Y
E
P
L
W
A
I
G
T
G
K
T
A
T
P
E
Q
A
Q
L
V
H
K
E
I
R
K
I
V
K
D
T
C
--
G
E
K
Q
A
N
Q
I
R
I
L
Y
G
G
S
V
N
T
E
N
C
S
S
L
I
Q
Q
E
D
I
D
G
F
L
V
G
N
A
S
L
K
-
E
S
F
V
D
I
I
----
119
PsiBlast_CBE
59.59
38%
13
- C6 -
-
1M7O
1
TPIS_PLAFA
A:
[3-244]
--
R
K
Y
F
V
A
A
N
W
K
C
N
G
T
L
E
S
I
K
S
L
T
N
S
F
-
N
N
-
L
D
F
D
P
S
K
--
L
D
V
V
V
F
P
V
S
V
H
-
Y
D
H
---
T
R
K
L
L
Q
--
S
K
F
S
---
T
--
G
I
Q
N
V
S
K
F
G
N
G
S
Y
T
G
E
V
S
A
E
I
A
K
D
L
N
I
E
Y
V
I
I
G
H
F
E
R
R
K
Y
F
H
E
T
D
E
D
V
R
E
K
L
Q
A
S
L
K
N
N
L
K
A
V
V
C
F
G
E
S
L
E
Q
R
E
Q
N
K
T
I
E
V
I
T
K
Q
V
K
A
F
V
D
L
I
--
D
N
F
D
N
V
--
I
L
V
Y
E
P
L
W
A
I
G
T
G
K
T
A
T
P
E
Q
A
Q
L
V
H
K
E
I
R
K
I
V
K
D
T
C
--
G
E
K
Q
A
N
Q
I
R
I
L
Y
G
G
S
V
N
T
E
N
C
S
S
L
I
Q
Q
E
D
I
D
G
F
L
V
G
N
A
S
L
K
-
E
S
F
V
D
I
I
----
118
PsiBlast_CBE
59.56
38%
12
- C6 -
-
1M7O
1
TPIS_PLAFA
B:
[3-244]
--
R
K
Y
F
V
A
A
N
W
K
C
N
G
T
L
E
S
I
K
S
L
T
N
S
F
-
N
N
-
L
D
FD
P
S
K
--
L
D
V
V
V
F
P
V
S
V
H
-
Y
D
H
---
T
R
K
L
L
Q
--
S
K
F
S
---
T
--
G
I
Q
N
V
S
K
F
G
N
G
S
Y
T
G
E
V
S
A
E
I
A
K
D
L
N
I
E
Y
V
I
I
G
H
F
E
R
R
K
Y
F
H
E
T
D
E
D
V
R
E
K
L
Q
A
S
L
K
N
N
L
K
A
V
V
C
F
G
E
S
L
E
Q
R
E
Q
N
K
T
I
E
V
I
T
K
Q
V
K
A
F
V
D
L
I
--
D
N
F
D
N
V
--
I
L
V
Y
E
P
L
W
A
I
G
T
G
K
T
A
T
P
E
Q
A
Q
L
V
H
K
E
I
R
K
I
V
K
D
T
C
--
G
E
K
Q
A
N
Q
I
R
I
L
Y
G
G
S
V
N
T
E
N
C
S
S
L
I
Q
Q
E
D
I
D
G
F
L
V
G
N
A
S
L
K
-
E
S
F
V
D
I
I
----
113
PsiBlast_CBE
59.55
38%
16
- C6 -
-
2VFI
3
TPIS_PLAFA
A:
[3-244]
--
R
K
Y
F
V
A
A
N
W
K
C
N
G
T
L
E
S
I
K
S
L
T
N
S
F
-
N
N
-
L
D
F
D
P
S
K
--
L
D
V
V
V
F
P
V
S
V
H
-
Y
D
H
---
T
R
K
L
L
Q
--
S
K
F
S
---
T
--
G
I
Q
N
V
S
K
F
G
N
G
S
Y
T
G
E
V
S
A
E
I
A
K
D
L
N
I
E
Y
V
I
I
G
H
F
E
R
R
K
Y
F
H
E
T
D
E
D
V
R
E
K
L
Q
A
S
L
K
N
N
L
K
A
V
V
C
F
G
E
S
L
E
Q
R
E
Q
N
K
T
I
E
V
I
T
K
Q
V
K
A
F
V
D
L
I
--
D
N
F
D
N
V
--
I
L
V
Y
E
P
L
W
A
I
G
T
G
K
T
A
T
P
E
Q
A
Q
L
V
H
K
E
I
R
K
I
V
K
D
T
C
--
G
E
K
Q
A
N
Q
I
R
I
L
Y
G
G
S
V
N
T
E
N
C
S
S
L
I
Q
Q
E
D
I
D
G
F
L
V
G
N
A
S
L
K
-
E
S
F
V
D
I
I
----
111
PsiBlast_CBE
59.55
38%
11
- C6 -
-
4YXG
3
TPIS_PLAFA
A:
[3-244]
--
R
K
Y
F
V
A
A
N
W
K
C
N
G
T
L
E
S
I
K
S
L
T
N
S
F
-
N
N
-
L
D
FD
P
S
K
--
L
D
V
V
V
F
P
V
S
V
H
-
Y
D
H
---
T
R
K
L
L
Q
--
S
K
F
S
---
T
--
G
I
Q
N
V
S
K
F
G
N
G
S
Y
T
G
E
V
S
A
E
I
A
K
D
L
N
I
E
Y
V
I
I
G
H
Y
E
R
R
K
Y
F
H
E
T
D
E
D
V
R
E
K
L
Q
A
S
L
K
N
N
L
K
A
V
V
C
F
G
E
S
L
E
Q
R
E
Q
N
K
T
I
E
V
I
T
K
Q
V
K
A
F
V
D
L
I
--
D
N
F
D
N
V
--
I
L
V
Y
E
P
L
W
--------
T
P
E
Q
A
Q
L
V
H
K
E
I
R
K
I
V
K
D
T
C
--
G
E
K
Q
A
N
Q
I
R
I
L
Y
G
G
S
V
N
T
E
N
C
S
S
L
I
Q
Q
E
D
I
D
G
F
L
V
G
N
A
S
L
K
-
E
S
F
V
D
I
I
----
132
PsiBlast_CBE
59.45
38%
8
- C6 -
-
5BMX
2
TPIS_PLAFA
D:
[3-244]
--
R
K
Y
F
V
A
A
N
W
K
C
N
G
T
L
E
S
I
K
S
L
T
N
S
F
-
N
N
-
L
D
FD
P
S
K
--
L
D
V
V
V
F
P
V
S
V
H
-
Y
D
H
---
T
R
K
L
L
Q
--
S
K
F
S
---
T
--
G
I
Q
N
V
S
K
F
G
N
G
S
Y
N
G
E
V
S
A
E
I
A
K
D
L
N
I
E
Y
V
I
I
G
H
F
E
R
R
K
Y
F
H
E
T
D
E
D
V
R
E
K
L
Q
A
S
L
K
N
N
L
K
A
V
V
C
F
G
E
S
L
E
Q
R
E
Q
-
K
T
I
E
V
I
T
K
Q
V
K
A
F
V
D
L
I
--
D
N
F
D
N
V
--
I
L
V
Y
E
P
L
W
A
------
A
T
P
E
Q
A
Q
L
V
H
K
E
I
R
K
I
V
K
D
T
C
--
G
E
K
Q
A
N
Q
I
R
I
L
Y
G
G
S
V
N
T
E
N
C
S
S
L
I
Q
Q
E
D
I
D
G
F
L
V
G
N
A
S
L
K
-
E
S
F
V
D
I
I
----
88
PsiBlast_CBE
59.37
39%
11
- C6 -
-
4Z0J
10
TPIS_PLAFA
B:
[2-244]
-
A
R
K
Y
F
V
A
A
N
W
K
C
N
G
T
L
E
S
I
K
S
L
T
N
S
F
-
N
N
-
L
D
F
D
P
S
K
--
L
D
V
V
V
F
P
V
S
V
H
-
Y
D
H
---
T
R
K
L
L
Q
--
S
K
F
S
---
T
--
G
I
Q
N
V
S
K
F
G
N
G
A
Y
T
G
E
V
S
A
E
I
A
K
D
L
N
I
E
Y
V
I
I
G
H
S
E
R
R
K
Y
F
H
E
T
D
E
D
V
R
E
K
L
Q
A
S
L
K
N
N
L
K
A
V
V
C
F
G
E
S
L
E
Q
R
E
Q
N
K
T
I
E
V
I
T
K
Q
V
K
A
F
V
D
L
I
--
D
N
F
D
N
V
--
I
L
V
Y
E
P
L
W
A
I
G
T
G
K
T
A
T
P
E
Q
A
Q
L
V
H
K
E
I
R
K
I
V
K
D
T
C
--
G
E
K
Q
A
N
Q
I
R
I
L
Y
G
G
S
------
S
S
L
I
Q
Q
E
D
I
D
G
F
L
V
G
N
A
S
L
K
-
E
S
F
V
D
I
I
----
116
PsiBlast_CBE
59.35
38%
12
- C6 -
-
1M7P
1
TPIS_PLAFA
B:
[3-244]
--
R
K
Y
F
V
A
A
N
W
K
C
N
G
T
L
E
S
I
K
S
L
T
N
S
F
-
N
N
-
L
D
FD
P
S
K
--
L
D
V
V
V
F
P
V
S
V
H
-
Y
D
H
---
T
R
K
L
L
Q
--
S
K
F
S
---
T
--
G
I
Q
N
V
S
K
F
G
N
G
S
Y
T
G
E
V
S
A
E
I
A
K
D
L
N
I
E
Y
V
I
I
G
H
F
E
R
R
K
Y
F
H
E
T
D
E
D
V
R
E
K
L
Q
A
S
L
K
N
N
L
K
A
V
V
C
F
G
E
S
L
E
Q
R
E
Q
N
K
T
I
E
V
I
T
K
Q
V
K
A
F
V
D
L
I
--
D
N
F
D
N
V
--
I
L
V
Y
E
P
L
W
A
I
G
T
G
K
T
A
T
P
E
Q
A
Q
L
V
H
K
E
I
R
K
I
V
K
D
T
C
--
G
E
K
Q
A
N
Q
I
R
I
L
Y
G
G
S
V
N
T
E
N
C
S
S
L
I
Q
Q
E
D
I
D
G
F
L
V
G
N
A
S
L
K
-
E
S
F
V
D
I
I
----
122
PsiBlast_CBE
59.31
38%
16
- C6 -
-
1LYX
1
TPIS_PLAFA
A:
[3-244]
--
R
K
Y
F
V
A
A
N
W
K
C
N
G
T
L
E
S
I
K
S
L
T
N
S
F
-
N
N
-
L
D
F
D
P
S
K
--
L
D
V
V
V
F
P
V
S
V
H
-
Y
D
H
---
T
R
K
L
L
Q
--
S
K
F
S
---
T
--
G
I
Q
N
V
S
K
F
G
N
G
S
Y
T
G
E
V
S
A
E
I
A
K
D
L
N
I
E
Y
V
I
I
G
H
F
E
R
R
K
Y
F
H
E
T
D
E
D
V
R
E
K
L
Q
A
S
L
K
N
N
L
K
A
V
V
C
F
G
E
S
L
E
Q
R
E
Q
N
K
T
I
E
V
I
T
K
Q
V
K
A
F
V
D
L
I
--
D
N
F
D
N
V
--
I
L
V
Y
E
P
L
W
A
I
G
T
G
K
T
A
T
P
E
Q
A
Q
L
V
H
K
E
I
R
K
I
V
K
D
T
C
--
G
E
K
Q
A
N
Q
I
R
I
L
Y
G
G
S
V
N
T
E
N
C
S
S
L
I
Q
Q
E
D
I
D
G
F
L
V
G
N
A
S
L
K
-
E
S
F
V
D
I
I
----
110
PsiBlast_CBE
59.14
38%
9
- C6 -
-
4Z0S
4
TPIS_PLAFA
A:
[2-244]
-
A
R
K
Y
F
V
A
A
N
W
K
C
N
G
T
L
E
S
I
K
S
L
T
N
S
F
-
N
N
-
L
D
F
D
P
S
K
--
L
D
V
V
V
F
P
V
S
V
H
-
Y
D
H
---
T
R
K
L
L
Q
--
S
K
F
S
---
T
--
G
I
Q
N
V
S
K
F
G
N
G
S
Y
T
G
E
V
S
A
E
I
A
K
D
L
N
I
E
Y
V
I
I
G
H
A
E
R
R
K
Y
F
H
E
T
D
E
D
V
R
E
K
L
Q
A
S
L
K
N
N
L
K
A
V
V
C
F
G
E
S
L
E
Q
R
E
Q
N
K
T
I
E
V
I
T
K
Q
V
K
A
F
V
D
L
I
--
D
N
F
D
N
V
--
I
L
V
Y
E
P
L
W
A
I
G
T
G
K
T
A
T
P
E
Q
A
Q
L
V
H
K
E
I
R
K
I
V
K
D
T
C
--
G
E
K
Q
A
N
Q
I
R
I
L
Y
G
G
S
V
N
T
E
N
C
S
S
L
I
Q
Q
E
D
I
D
G
F
L
V
G
N
A
S
L
K
-
E
S
F
V
D
I
I
----
99
PsiBlast_CBE
59.05
39%
10
- C6 -
-
2VFE
3
TPIS_PLAFA
B:
[3-244]
--
R
K
Y
F
V
A
A
N
W
K
C
N
G
T
L
E
S
I
K
S
L
T
N
S
F
-
N
N
-
L
D
F
D
P
S
K
--
L
D
V
V
V
F
P
V
S
V
H
-
Y
D
H
---
T
R
K
L
L
Q
--
S
K
F
S
---
T
--
G
I
Q
N
V
S
K
F
G
N
G
S
Y
T
G
E
V
S
A
E
I
A
K
D
L
N
I
E
Y
V
I
I
G
H
S
E
R
R
K
Y
F
H
E
T
D
E
D
V
R
E
K
L
Q
A
S
L
K
N
N
L
K
A
V
V
C
F
G
E
S
L
E
Q
R
E
Q
N
K
T
I
E
V
I
T
K
Q
V
K
A
F
V
D
L
I
--
D
N
F
D
N
V
--
I
L
V
Y
E
P
L
W
A
I
G
T
G
K
T
A
T
P
E
Q
A
Q
L
V
H
K
E
I
R
K
I
V
K
D
T
C
--
G
E
K
Q
A
N
Q
I
R
I
L
Y
G
G
S
------
S
S
L
I
Q
Q
E
D
I
D
G
F
L
V
G
N
A
S
L
K
-
E
S
F
V
D
I
I
----
121
PsiBlast_CBE
58.59
38%
18
- C6 -
-
1LZO
1
TPIS_PLAFA
B:
[3-244]
--
R
K
Y
F
V
A
A
N
W
K
C
N
G
T
L
E
S
I
K
S
L
T
N
S
F
-
N
N
-
L
D
FD
P
S
K
--
L
D
V
V
V
F
P
V
S
V
H
-
Y
D
H
---
T
R
K
L
L
Q
--
S
K
F
S
---
T
--
G
I
Q
N
V
S
K
F
G
N
G
S
Y
T
G
E
V
S
A
E
I
A
K
D
L
N
I
E
Y
V
I
I
G
H
F
E
R
R
K
Y
F
H
E
T
D
E
D
V
R
E
K
L
Q
A
S
L
K
N
N
L
K
A
V
V
C
F
G
E
S
L
E
Q
R
E
Q
N
K
T
I
E
V
I
T
K
Q
V
K
A
F
V
D
L
I
--
D
N
F
D
N
V
--
I
L
V
Y
E
P
L
W
A
I
G
T
G
K
T
A
T
P
E
Q
A
Q
L
V
H
K
E
I
R
K
I
V
K
D
T
C
--
G
E
K
Q
A
N
Q
I
R
I
L
Y
G
G
S
V
N
T
E
N
C
S
S
L
I
Q
Q
E
D
I
D
G
F
L
V
G
N
A
S
L
K
-
E
S
F
V
D
I
I
----
120
PsiBlast_CBE
57.98
38%
19
- C6 -
-
1LZO
1
TPIS_PLAFA
D:
[3-244]
--
R
K
Y
F
V
A
A
N
W
K
C
N
G
T
L
E
S
I
K
S
L
T
N
S
F
-
N
N
-
L
D
FD
P
S
K
--
L
D
V
V
V
F
P
V
S
V
H
-
Y
D
H
---
T
R
K
L
L
Q
--
S
K
F
S
---
T
--
G
I
Q
N
V
S
K
F
G
N
G
S
Y
T
G
E
V
S
A
E
I
A
K
D
L
N
I
E
Y
V
I
I
G
H
F
E
R
R
K
Y
F
H
E
T
D
E
D
V
R
E
K
L
Q
A
S
L
K
N
N
L
K
A
V
V
C
F
G
E
S
L
E
Q
R
E
Q
N
K
T
I
E
V
I
T
K
Q
V
K
A
F
V
D
L
I
--
D
N
F
D
N
V
--
I
L
V
Y
E
P
L
W
A
I
G
T
G
K
T
A
T
P
E
Q
A
Q
L
V
H
K
E
I
R
K
I
V
K
D
T
C
--
G
E
K
Q
A
N
Q
I
R
I
L
Y
G
G
S
V
N
T
E
N
C
S
S
L
I
Q
Q
E
D
I
D
G
F
L
V
G
N
A
S
L
K
-
E
S
F
V
D
I
I
----