@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : spr1510: (2018-01-13 )
MTFSFDTAAAQGAVIKVIGVGGGGGNAINRMVDEGVTGVEFIAANTDVQALSSTKAETVIQLGPKLTRGLGAGGQPEVGRKAAEESEETLTEAISGADMVFITAGMGGGSGTGAAPVIARIAKDLGALTVGVVTRPFGFEGSKRGQFAVEGINQLREHVDTLLIISNNNLLEIVDKKTPLLEALSEADNVLRQGVQGITDLITNPGLINLDFADVKTVMANKGNALMGIGIGSGEERVVEAARKAIYSPLLETTIDGAEDVIVNVTGGLDLTLIEAEEASQIVNQAAGQGVNIWLGTSIDESMRDEIRVTVVATGVRQDRVEKVVAPQARSATNYRETVKPAHSHGFDRHFDMAETVELPKQNPRRLEPTQASAFGDWDLRRESIVRTTDSVVSPVERFEAPISQDEDELDTPPFFKNR
Atome Classification :
(65 SA)
---.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.--........220.......230.......240.......250-.......260.......270.......280.......290.......300.-......310...-....320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
---MTFSFDTAAAQ
G
A
V
I
K
V
I
G
VGGG
G
G
N
A
I
N
R
M
V
DEGVT
G
V
E
F
I
AANT
D
V
Q
A
L
SSTK
A
E
T
V
I
QLGP
K
L
T
R
GLGAGGQ
P
E
V
G
R
K
A
A
E
E
S
E
E
T
L
T
E
AISGA
D
M
V
F
I
T
AGMGGGSGT
G
A
A
P
V
I
A
R
I
A
K
D
L
G
A
L
T
V
G
V
V
TRPFGFEGSKRG
Q
F
A
V
E
G
I
N
Q
L
R
E
HV
D
T
L
L
I
I
SNN
N
L
L
E
IVDKK
T
P
L
L
E
A
L
S
E
A
D
N
V
L
R
Q
G
V
Q
G
I
T
D
LITNP
G
L
I
N
L--
D
--
F
A
D
V
K
T
V
M
ANKG
N
A
L
M
G
I
GIGS
G
E
E
R
V
V
E
A
A
R
K
A
I
Y
S
P
L
L
E
-
T
TIDGA
E
D
V
I
V
N
VTGG
L
D
L
T
L
I
E
A
E
E
A
S
Q
I
V
N
Q
AAGQ
G
V
N
I
W
LGTSI
D
E
S
M
-RD
E
I
R
V
T
V
V
ATG-V
R
Q
D
R
V
E
K
V
VAPQARSATN
Y
R
E
TVKPAHSHGFDRHF
D
M
A
E
T
VELPKQNPRRLEPTQASAFG
D
W
D
L
R
R
E
S
I
V
RT
T
D
S
V
V
S
P
V
E
R
FEAPISQDEDELDTPPFFKNR
78
HHSearch
95.04
63%
-101
- C3 -
-
4M8I
1
FTSZ_STAEQ
A:
[17-327]
--------------
L
A
T
L
K
V
I
G
V
G
G
G
G
N
N
A
V
N
R
M
I
D
H
G
M
N
N
V
E
F
I
A
I
N
T
D
G
Q
A
L
N
L
S
K
A
E
S
K
I
Q
I
G
E
K
L
T
R
G
L
G
A
G
A
N
P
E
I
G
K
K
A
A
E
E
S
R
E
Q
I
E
D
A
I
Q
G
A
D
M
V
F
V
T
A
G
M
G
G
G
T
G
T
G
A
A
P
V
V
A
K
I
A
K
E
M
G
A
L
T
V
G
V
V
T
R
P
F
G
F
E
G
R
K
R
Q
T
Q
A
A
A
G
V
E
S
M
K
A
A
V
D
T
L
I
V
I
P
N
D
R
L
L
D
I
V
D
K
S
T
P
M
M
E
A
F
K
E
A
D
N
V
L
R
Q
G
V
Q
G
I
S
D
L
I
A
V
S
G
E
V
N
L
--
D
--
F
A
D
V
K
T
I
M
S
N
Q
G
S
A
L
M
G
I
G
V
S
S
G
E
N
R
A
V
E
A
A
K
K
A
I
S
S
P
L
L
E
-
T
S
I
V
G
A
Q
G
V
L
M
N
I
T
G
G
E
S
L
S
L
F
E
A
Q
E
A
A
D
I
V
Q
D
A
A
D
E
D
V
N
M
I
F
G
T
V
I
N
P
E
L
-
Q
D
E
I
V
V
T
V
I
A
T
G
-
F
E
D
K
P
S
S
-------------------------------------------------------------------------------------------------
86
HHSearch
94.53
64%
-104
- C3 -
-
5MN4
2
FTSZ_STAAU
A:
[1-304]
---------------
A
T
L
K
V
I
G
V
G
G
G
G
N
N
A
V
N
R
M
I
D
H
G
M
N
N
V
E
F
I
A
I
N
T
D
G
Q
A
L
N
L
S
K
A
E
S
K
I
Q
I
G
E
K
L
T
R
G
L
G
A
G
A
N
P
E
I
G
K
K
A
A
E
E
S
R
E
Q
I
E
D
A
I
Q
G
A
D
M
V
F
V
T
S
G
M
G
G
G
T
G
T
G
A
A
P
V
V
A
K
I
A
K
E
M
G
A
L
T
V
G
V
V
T
R
P
F
S
A
E
G
R
K
R
Q
T
Q
A
A
A
G
V
E
A
M
K
A
A
V
D
T
L
I
V
I
P
N
D
R
L
L
D
I
V
D
K
S
T
P
M
M
E
A
F
K
E
A
D
N
V
L
R
Q
G
V
Q
G
I
S
D
L
I
A
V
S
G
E
V
N
L
--
D
--
F
A
D
V
K
T
I
M
S
N
Q
G
S
A
L
M
G
I
G
V
S
S
G
E
N
R
A
V
E
A
A
K
K
A
I
S
S
P
L
L
E
-
T
S
I
V
G
A
Q
G
V
L
M
N
I
T
G
G
E
S
L
S
L
F
E
A
Q
E
A
A
D
I
V
Q
D
A
A
D
E
D
V
N
M
I
F
G
T
V
I
N
P
E
L
-
Q
D
E
I
V
V
T
V
I
A
T
G
-
F
-------------------------------------------------------------------------------------------------------
74
HHSearch
94.33
65%
-110
- C3 -
-
2VXY
1
FTSZ_BACSU
A:
[11-316]
--------------
L
A
S
I
K
V
I
G
V
G
G
G
G
N
N
A
V
N
R
M
I
E
N
E
V
Q
G
V
E
Y
I
A
V
N
T
D
A
Q
A
L
N
L
S
K
A
E
V
K
M
Q
I
G
A
K
L
T
R
G
L
G
A
G
A
N
P
E
V
G
K
K
A
A
E
E
S
K
E
Q
I
E
E
A
L
K
G
A
D
M
V
F
V
T
A
G
M
G
G
G
T
G
T
G
A
A
P
V
I
A
Q
I
A
K
D
L
G
A
L
T
V
G
V
V
T
R
P
F
T
F
E
G
R
K
R
Q
L
Q
A
A
G
G
I
S
A
M
K
E
A
V
D
T
L
I
V
I
P
N
D
R
I
L
E
I
V
D
K
N
T
P
M
L
E
A
F
R
E
A
D
N
V
L
R
Q
G
V
Q
G
I
S
D
L
I
A
T
P
G
L
I
N
L
--
D
--
F
A
D
V
K
T
I
M
S
N
K
G
S
A
L
M
G
I
G
I
A
T
G
E
N
R
A
A
E
A
A
K
K
A
I
S
S
P
L
L
E
-
A
A
I
D
G
A
Q
G
V
L
M
N
I
T
G
G
T
N
L
S
L
Y
E
V
Q
E
A
A
D
I
V
A
S
A
S
D
Q
D
V
N
M
I
F
G
S
V
I
N
E
N
L
-
K
D
E
I
V
V
T
V
I
A
T
G
-
F
I
------------------------------------------------------------------------------------------------------
87
HHSearch
93.93
58%
-120
- C3 -
-
4E6E
-
?
A:
[5-313]
----------
P
Q
N
Y
L
A
V
I
K
V
V
G
I
G
G
G
G
V
N
A
V
N
R
M
I
E
E
G
L
K
G
V
E
F
I
A
I
N
T
D
A
Q
A
L
L
M
S
D
A
D
V
K
L
D
V
G
R
E
L
T
R
----
G
A
N
P
D
V
G
R
K
A
A
E
D
H
R
E
E
I
E
E
V
L
K
G
A
D
M
V
F
V
T
A
G
E
G
G
G
T
G
T
G
G
A
P
V
V
A
N
I
A
R
S
L
G
A
L
T
I
G
V
V
T
R
P
F
S
F
E
G
K
R
R
A
T
Q
A
E
A
G
I
A
M
L
R
E
E
V
D
T
L
I
V
I
P
N
D
R
L
L
---
D
R
Q
V
S
V
L
D
A
F
K
A
A
D
Q
V
L
L
S
G
V
Q
G
I
T
D
L
I
T
T
P
G
L
I
N
L
--
D
--
F
A
D
V
K
S
V
M
S
G
A
G
S
A
L
M
G
I
G
S
A
R
G
D
D
R
A
V
A
A
A
E
M
A
I
S
S
P
L
L
E
-
A
S
I
D
G
A
H
G
V
L
L
S
I
Q
G
G
S
D
L
G
L
F
E
I
N
E
A
A
Q
L
V
A
N
S
A
A
A
E
A
N
I
I
F
G
A
V
I
D
D
A
L
-
G
D
E
V
R
V
T
V
I
A
A
G
-
F
-------------------------------------------------------------------------------------------------------
76
HHSearch
93.00
62%
-102
- C3 -
-
3WGL
1
FTSZ_STAAM
B:
[13-316]
--------------
L
A
T
L
K
V
I
G
V
G
G
G
G
N
N
A
V
N
R
M
I
D
H
G
M
N
N
V
E
F
I
A
I
N
T
D
G
Q
A
L
N
L
S
K
A
E
S
K
I
Q
I
G
E
K
L
T
R
G
L
G
A
G
A
N
P
E
I
G
K
K
A
A
E
E
S
R
E
Q
I
E
D
A
I
Q
G
A
D
M
V
F
V
T
S
G
M
G
G
G
T
G
T
G
A
A
P
V
V
A
K
I
A
K
E
M
G
A
L
T
V
G
V
V
T
R
P
F
S
F
E
G
R
K
R
Q
T
Q
A
A
A
G
V
E
A
M
K
A
A
V
D
T
L
I
V
I
P
N
D
R
L
L
D
I
V
D
K
S
T
P
M
M
E
A
F
K
E
A
D
N
V
L
R
Q
G
V
Q
G
I
S
D
L
I
A
V
G
--
A
N
L
--
D
--
F
A
D
V
K
T
I
M
S
N
Q
G
S
A
L
M
G
I
G
V
S
S
G
E
N
R
A
V
E
A
A
K
K
A
I
S
S
P
L
L
E
-
T
S
I
V
G
A
Q
G
V
L
M
N
I
T
G
G
E
S
L
S
L
F
E
A
Q
E
A
A
D
I
V
Q
D
A
A
D
E
D
V
N
M
I
F
G
T
V
I
N
P
E
L
-
Q
D
E
I
V
V
T
V
I
A
T
G
-
F
D
------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
92.94
64%
-109
- C3 -
-
5H5H
1
?
A:
[4-306]
---------------
A
T
L
K
V
I
G
V
G
G
G
G
N
N
A
V
N
A
M
I
D
H
G
M
N
N
V
E
F
I
A
I
N
T
D
G
Q
A
L
N
L
S
K
A
E
S
K
I
Q
I
G
E
K
L
T
R
G
L
G
A
G
A
N
P
E
I
G
K
K
A
A
E
E
S
R
E
Q
I
E
D
A
I
Q
G
A
D
M
V
F
V
T
S
G
M
G
G
G
T
G
T
G
A
A
P
V
V
A
K
I
A
K
E
M
G
A
L
T
V
G
V
V
T
R
P
F
S
F
E
G
R
K
R
Q
T
Q
A
A
A
G
V
E
A
M
K
A
A
V
D
T
L
I
V
I
P
N
D
R
L
L
D
I
V
D
K
S
T
P
M
M
E
A
F
K
E
A
D
N
V
L
R
Q
G
V
Q
G
I
S
D
L
I
A
V
S
G
E
V
N
L
--
D
--
F
A
D
V
K
T
I
M
S
N
Q
G
S
A
L
M
G
I
G
V
S
S
G
E
N
R
A
V
E
A
A
K
K
A
I
S
S
P
L
L
E
-
T
S
I
V
G
A
Q
G
V
L
M
N
I
T
G
G
E
S
L
S
L
F
E
A
Q
E
A
A
D
I
V
Q
D
A
A
D
E
D
V
N
M
I
F
G
T
V
I
N
P
E
L
-
Q
D
E
I
V
V
T
V
I
A
T
G
---------------------------------------------------------------------------------------------------------
70
PsiBlast_CBE
91.25
50%
-113
- C3 -
-
1W5A
1
FTSZ1_METJA
A:
[38-345]
---------------
A
K
I
T
V
V
G
C
G
G
A
G
N
N
T
I
T
R
L
K
M
E
G
I
E
G
A
K
T
V
A
I
N
T
D
A
Q
Q
L
I
R
T
K
A
D
K
K
I
L
I
G
K
K
L
T
R
G
L
G
A
G
G
N
P
K
I
G
E
E
A
A
K
E
S
A
E
E
I
K
A
A
I
Q
D
S
D
M
V
F
I
T
C
G
L
G
G
G
T
G
T
G
S
A
P
V
V
A
E
I
S
K
K
I
G
A
L
T
V
A
V
V
T
L
P
F
V
M
E
G
K
V
R
M
K
N
A
M
E
G
L
E
R
L
K
Q
H
T
D
T
L
V
V
I
P
N
E
K
L
F
E
I
V
-
P
N
M
P
L
K
L
A
F
K
V
A
D
E
V
L
I
N
A
V
K
G
L
V
E
L
I
T
K
D
G
L
I
N
V
--
D
--
F
A
D
V
K
A
V
M
N
N
G
G
L
A
M
I
G
I
G
E
S
D
S
E
K
R
A
K
E
A
V
S
M
A
L
N
S
P
L
L
D
-
V
D
I
D
G
A
T
G
A
L
I
H
V
M
G
P
E
D
L
T
L
E
E
A
R
E
V
V
A
T
V
S
S
R
L
D
P
N
A
T
I
I
W
G
A
T
I
D
E
N
L
-
E
N
T
V
R
V
L
L
V
I
T
G
-
V
-
Q
S
R
I
E
-------------------------------------------------------------------------------------------------
68
PsiBlast_CBE
91.22
50%
-118
- C3 -
-
1W5B
1
FTSZ1_METJA
A:
[38-345]
---------------
A
K
I
T
V
V
G
C
G
G
A
G
N
N
T
I
T
R
L
K
M
E
G
I
E
G
A
K
T
V
A
I
N
T
D
A
Q
Q
L
I
R
T
K
A
D
K
K
I
L
I
G
K
K
L
T
R
G
L
G
A
G
G
N
P
K
I
G
E
E
A
A
K
E
S
A
E
E
I
K
A
A
I
Q
D
S
D
M
V
F
I
T
C
G
L
G
G
G
T
G
T
G
S
A
P
V
V
A
E
I
S
K
K
I
G
A
L
T
V
A
V
V
T
L
P
F
V
M
E
G
K
V
R
M
K
N
A
M
E
G
L
E
R
L
K
Q
H
T
D
T
L
V
V
I
P
N
E
K
L
F
E
I
V
-
P
N
M
P
L
K
L
A
F
K
V
A
D
E
V
L
I
N
A
V
K
G
L
V
E
L
I
T
K
D
G
L
I
N
V
--
D
--
F
A
D
V
K
A
V
M
N
N
G
G
L
A
M
I
G
I
G
E
S
D
S
E
K
R
A
K
E
A
V
S
M
A
L
N
S
P
L
L
D
-
V
D
I
D
G
A
T
G
A
L
I
H
V
M
G
P
E
D
L
T
L
E
E
A
R
E
V
V
A
T
V
S
S
R
L
D
P
N
A
T
I
I
W
G
A
T
I
D
E
N
L
-
E
N
T
V
R
V
L
L
V
I
T
G
-
V
-
Q
S
R
I
E
-------------------------------------------------------------------------------------------------
75
HHSearch
91.00
55%
-110
- C3 -
-
2Q1Y
1
FTSZ_MYCTU
A:
[8-312]
--------------
L
A
V
I
K
V
V
G
I
G
G
G
G
V
N
A
V
N
R
M
I
E
Q
G
L
K
G
V
E
F
I
A
I
N
T
D
A
Q
A
L
L
M
S
D
A
D
V
K
L
D
V
G
R
D
S
T
R
G
L
G
A
G
A
D
P
E
V
G
R
K
A
A
E
D
A
K
D
E
I
E
E
L
L
R
G
A
D
M
V
F
V
T
A
G
E
G
G
G
T
G
T
G
G
A
P
V
V
A
S
I
A
R
K
L
G
A
L
T
V
G
V
V
T
R
P
F
S
F
E
G
K
R
R
S
N
Q
A
E
N
G
I
A
A
L
R
E
S
C
D
T
L
I
V
I
P
N
D
R
L
L
Q
M
G
D
A
A
V
S
L
M
D
A
F
R
S
A
D
E
V
L
L
N
G
V
Q
G
I
T
D
L
I
T
T
P
G
L
I
N
V
--
D
--
F
A
D
V
K
G
I
M
S
G
A
G
T
A
L
M
G
I
G
S
A
R
G
E
G
R
S
L
K
A
A
E
I
A
I
N
S
P
L
L
E
-
A
S
M
E
G
A
Q
G
V
L
M
S
I
A
G
G
S
D
L
G
L
F
E
I
N
E
A
A
S
L
V
Q
D
A
A
H
P
D
A
N
I
I
F
G
T
V
I
D
D
S
L
-
G
D
E
V
R
V
T
V
I
A
A
G
-
F
-------------------------------------------------------------------------------------------------------
69
PsiBlast_CBE
90.91
50%
-115
- C3 -
-
1W5A
1
FTSZ1_METJA
B:
[38-345]
---------------
A
K
I
T
V
V
G
C
G
G
A
G
N
N
T
I
T
R
L
K
M
E
G
I
E
G
A
K
T
V
A
I
N
T
D
A
Q
Q
L
I
R
T
K
A
D
K
K
I
L
I
G
K
K
L
T
R
G
L
G
A
G
G
N
P
K
I
G
E
E
A
A
K
E
S
A
E
E
I
K
A
A
I
Q
D
S
D
M
V
F
I
T
C
G
L
G
G
G
T
G
T
G
S
A
P
V
V
A
E
I
S
K
K
I
G
A
L
T
V
A
V
V
T
L
P
F
V
M
E
G
K
V
R
M
K
N
A
M
E
G
L
E
R
L
K
Q
H
T
D
T
L
V
V
I
P
N
E
K
L
F
E
I
V
-
P
N
M
P
L
K
L
A
F
K
V
A
D
E
V
L
I
N
A
V
K
G
L
V
E
L
I
T
K
D
G
L
I
N
V
--
D
--
F
A
D
V
K
A
V
M
N
N
G
G
L
A
M
I
G
I
G
E
S
D
S
E
K
R
A
K
E
A
V
S
M
A
L
N
S
P
L
L
D
-
V
D
I
D
G
A
T
G
A
L
I
H
V
M
G
P
E
D
L
T
L
E
E
A
R
E
V
V
A
T
V
S
S
R
L
D
P
N
A
T
I
I
W
G
A
T
I
D
E
N
L
-
E
N
T
V
R
V
L
L
V
I
T
G
-
V
-
Q
S
R
I
E
-------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
90.84
64%
-107
- C3 -
-
5H5I
1
?
A:
[4-306]
---------------
A
T
L
K
V
I
G
V
G
G
G
G
N
N
A
V
N
A
M
I
D
H
G
M
N
N
V
E
F
I
A
I
N
T
D
G
Q
A
L
N
L
S
K
A
E
S
K
I
Q
I
G
E
K
L
T
R
G
L
G
A
G
A
N
P
E
I
G
K
K
A
A
E
E
S
R
E
Q
I
E
D
A
I
Q
G
A
D
M
V
F
V
T
S
G
M
G
G
G
T
G
T
G
A
A
P
V
V
A
K
I
A
K
E
M
G
A
L
T
V
G
V
V
T
R
P
F
S
F
E
G
R
K
R
Q
T
Q
A
A
A
G
V
E
A
M
K
A
A
V
D
T
L
I
V
I
P
N
D
R
L
L
D
I
V
D
K
S
T
P
M
M
E
A
F
K
E
A
D
N
V
L
R
Q
G
V
Q
G
I
S
D
L
I
A
V
S
G
E
V
N
L
--
D
--
F
A
D
V
K
T
I
M
S
N
Q
G
S
A
L
M
G
I
G
V
S
S
G
E
N
R
A
V
E
A
A
K
K
A
I
S
S
P
L
L
E
-
T
S
I
V
G
A
Q
G
V
L
M
N
I
T
G
G
E
S
L
S
L
F
E
A
Q
E
A
A
D
I
V
Q
D
A
A
D
E
D
V
N
M
I
F
G
T
V
I
N
P
E
L
-
Q
D
E
I
V
V
T
V
I
A
T
G
---------------------------------------------------------------------------------------------------------
60
PsiBlast_CBE
90.83
50%
-112
- C3 -
-
1W5E
1
FTSZ1_METJA
F:
[38-345]
---------------
A
K
I
T
V
V
G
C
G
G
A
G
N
N
T
I
T
R
L
K
M
E
G
I
E
G
A
K
T
V
A
I
N
T
D
A
Q
Q
L
I
R
T
K
A
D
K
K
I
L
I
G
K
K
L
T
R
G
L
G
A
G
G
N
P
K
I
G
E
E
A
A
K
E
S
A
E
E
I
K
A
A
I
Q
D
S
D
M
V
F
I
T
C
G
L
G
G
G
T
G
T
G
S
A
P
V
V
A
E
I
S
K
K
I
G
A
L
T
V
A
V
V
T
L
P
F
V
M
E
G
K
V
R
M
K
N
A
M
E
G
L
E
R
L
K
Q
H
T
D
T
L
V
V
I
P
N
E
K
L
F
E
I
V
-
P
N
M
P
L
K
L
A
F
K
V
A
D
E
V
L
I
N
A
V
K
G
L
V
E
L
I
T
K
D
G
L
I
N
V
--
D
--
F
A
D
V
K
A
V
M
N
N
G
G
L
A
M
I
G
I
G
E
S
D
S
E
K
R
A
K
E
A
V
S
M
A
L
N
S
P
L
L
D
-
V
D
I
D
G
A
T
G
A
L
I
H
V
M
G
P
E
D
L
T
L
E
E
A
R
E
V
V
A
T
V
S
S
R
L
D
P
N
A
T
I
I
Y
G
A
T
I
D
E
N
L
-
E
N
T
V
R
V
L
L
V
I
T
G
-
V
-
Q
S
R
I
E
-------------------------------------------------------------------------------------------------
83
HHSearch
90.63
49%
-111
- C3 -
-
1W59
-
FTSZ1_METJA
A:
[34-347]
-----------
Q
Q
T
K
A
K
I
T
V
V
G
C
G
G
A
G
N
N
T
I
T
R
L
K
M
E
G
I
E
G
A
K
T
V
A
I
N
T
D
A
Q
Q
L
I
R
T
K
A
D
K
K
I
L
I
G
K
K
L
T
R
G
L
G
A
G
G
N
P
K
I
G
E
E
A
A
K
E
S
A
E
E
I
K
A
A
I
Q
D
S
D
M
V
F
I
T
C
G
L
G
G
G
T
G
T
G
S
A
P
V
V
A
E
I
S
K
K
I
G
A
L
T
V
A
V
V
T
L
P
F
V
M
E
G
K
V
R
M
K
N
A
M
E
G
L
E
R
L
K
Q
H
T
D
T
L
V
V
I
P
N
E
K
L
F
E
I
V
P
-
N
M
P
L
K
L
A
F
K
V
A
D
E
V
L
I
N
A
V
K
G
L
V
E
L
I
T
K
D
G
L
I
N
V
--
D
--
F
A
D
V
K
A
V
M
N
N
G
G
L
A
M
I
G
I
G
E
S
D
S
E
K
R
A
K
E
A
V
S
M
A
L
N
S
P
L
L
D
-
V
D
I
D
G
A
T
G
A
L
I
H
V
M
G
P
E
D
L
T
L
E
E
A
R
E
V
V
A
T
V
S
S
R
L
D
P
N
A
T
I
I
W
G
A
T
I
D
E
N
L
-
E
N
T
V
R
V
L
L
V
I
T
G
-
V
Q
S
R
I
E
F
T
------------------------------------------------------------------------------------------------
58
PsiBlast_CBE
90.50
50%
-113
- C3 -
-
1W5E
1
FTSZ1_METJA
H:
[38-345]
---------------
A
K
I
T
V
V
G
C
G
G
A
G
N
N
T
I
T
R
L
K
M
E
G
I
E
G
A
K
T
V
A
I
N
T
D
A
Q
Q
L
I
R
T
K
A
D
K
K
I
L
I
G
K
K
L
T
R
G
L
G
A
G
G
N
P
K
I
G
E
E
A
A
K
E
S
A
E
E
I
K
A
A
I
Q
D
S
D
M
V
F
I
T
C
G
L
G
G
G
T
G
T
G
S
A
P
V
V
A
E
I
S
K
K
I
G
A
L
T
V
A
V
V
T
L
P
F
V
M
E
G
K
V
R
M
K
N
A
M
E
G
L
E
R
L
K
Q
H
T
D
T
L
V
V
I
P
N
E
K
L
F
E
I
V
-
P
N
M
P
L
K
L
A
F
K
V
A
D
E
V
L
I
N
A
V
K
G
L
V
E
L
I
T
K
D
G
L
I
N
V
--
D
--
F
A
D
V
K
A
V
M
N
N
G
G
L
A
M
I
G
I
G
E
S
D
S
E
K
R
A
K
E
A
V
S
M
A
L
N
S
P
L
L
D
-
V
D
I
D
G
A
T
G
A
L
I
H
V
M
G
P
E
D
L
T
L
E
E
A
R
E
V
V
A
T
V
S
S
R
L
D
P
N
A
T
I
I
Y
G
A
T
I
D
E
N
L
-
E
N
T
V
R
V
L
L
V
I
T
G
-
V
-
Q
S
R
I
E
-------------------------------------------------------------------------------------------------
57
PsiBlast_CBE
90.40
50%
-109
- C3 -
-
1W5E
1
FTSZ1_METJA
I:
[38-345]
---------------
A
K
I
T
V
V
G
C
G
G
A
G
N
N
T
I
T
R
L
K
M
E
G
I
E
G
A
K
T
V
A
I
N
T
D
A
Q
Q
L
I
R
T
K
A
D
K
K
I
L
I
G
K
K
L
T
R
G
L
G
A
G
G
N
P
K
I
G
E
E
A
A
K
E
S
A
E
E
I
K
A
A
I
Q
D
S
D
M
V
F
I
T
C
G
L
G
G
G
T
G
T
G
S
A
P
V
V
A
E
I
S
K
K
I
G
A
L
T
V
A
V
V
T
L
P
F
V
M
E
G
K
V
R
M
K
N
A
M
E
G
L
E
R
L
K
Q
H
T
D
T
L
V
V
I
P
N
E
K
L
F
E
I
V
-
P
N
M
P
L
K
L
A
F
K
V
A
D
E
V
L
I
N
A
V
K
G
L
V
E
L
I
T
K
D
G
L
I
N
V
--
D
--
F
A
D
V
K
A
V
M
N
N
G
G
L
A
M
I
G
I
G
E
S
D
S
E
K
R
A
K
E
A
V
S
M
A
L
N
S
P
L
L
D
-
V
D
I
D
G
A
T
G
A
L
I
H
V
M
G
P
E
D
L
T
L
E
E
A
R
E
V
V
A
T
V
S
S
R
L
D
P
N
A
T
I
I
Y
G
A
T
I
D
E
N
L
-
E
N
T
V
R
V
L
L
V
I
T
G
-
V
-
Q
S
R
I
E
-------------------------------------------------------------------------------------------------
59
PsiBlast_CBE
90.22
50%
-110
- C3 -
-
1W5E
1
FTSZ1_METJA
G:
[38-345]
---------------
A
K
I
T
V
V
G
C
G
G
A
G
N
N
T
I
T
R
L
K
M
E
G
I
E
G
A
K
T
V
A
I
N
T
D
A
Q
Q
L
I
R
T
K
A
D
K
K
I
L
I
G
K
K
L
T
R
G
L
G
A
G
G
N
P
K
I
G
E
E
A
A
K
E
S
A
E
E
I
K
A
A
I
Q
D
S
D
M
V
F
I
T
C
G
L
G
G
G
T
G
T
G
S
A
P
V
V
A
E
I
S
K
K
I
G
A
L
T
V
A
V
V
T
L
P
F
V
M
E
G
K
V
R
M
K
N
A
M
E
G
L
E
R
L
K
Q
H
T
D
T
L
V
V
I
P
N
E
K
L
F
E
I
V
-
P
N
M
P
L
K
L
A
F
K
V
A
D
E
V
L
I
N
A
V
K
G
L
V
E
L
I
T
K
D
G
L
I
N
V
--
D
--
F
A
D
V
K
A
V
M
N
N
G
G
L
A
M
I
G
I
G
E
S
D
S
E
K
R
A
K
E
A
V
S
M
A
L
N
S
P
L
L
D
-
V
D
I
D
G
A
T
G
A
L
I
H
V
M
G
P
E
D
L
T
L
E
E
A
R
E
V
V
A
T
V
S
S
R
L
D
P
N
A
T
I
I
Y
G
A
T
I
D
E
N
L
-
E
N
T
V
R
V
L
L
V
I
T
G
-
V
-
Q
S
R
I
E
-------------------------------------------------------------------------------------------------
63
PsiBlast_CBE
90.03
50%
-107
- C3 -
-
1W5E
1
FTSZ1_METJA
C:
[38-345]
---------------
A
K
I
T
V
V
G
C
G
G
A
G
N
N
T
I
T
R
L
K
M
E
G
I
E
G
A
K
T
V
A
I
N
T
D
A
Q
Q
L
I
R
T
K
A
D
K
K
I
L
I
G
K
K
L
T
R
G
L
G
A
G
G
N
P
K
I
G
E
E
A
A
K
E
S
A
E
E
I
K
A
A
I
Q
D
S
D
M
V
F
I
T
C
G
L
G
G
G
T
G
T
G
S
A
P
V
V
A
E
I
S
K
K
I
G
A
L
T
V
A
V
V
T
L
P
F
V
M
E
G
K
V
R
M
K
N
A
M
E
G
L
E
R
L
K
Q
H
T
D
T
L
V
V
I
P
N
E
K
L
F
E
I
V
-
P
N
M
P
L
K
L
A
F
K
V
A
D
E
V
L
I
N
A
V
K
G
L
V
E
L
I
T
K
D
G
L
I
N
V
--
D
--
F
A
D
V
K
A
V
M
N
N
G
G
L
A
M
I
G
I
G
E
S
D
S
E
K
R
A
K
E
A
V
S
M
A
L
N
S
P
L
L
D
-
V
D
I
D
G
A
T
G
A
L
I
H
V
M
G
P
E
D
L
T
L
E
E
A
R
E
V
V
A
T
V
S
S
R
L
D
P
N
A
T
I
I
Y
G
A
T
I
D
E
N
L
-
E
N
T
V
R
V
L
L
V
I
T
G
-
V
-
Q
S
R
I
E
-------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
90.01
67%
-108
- C3 -
-
4U39
-
FTSZ_BACSU
A:
[19-304]
--------------------------------
R
M
I
E
N
E
V
Q
G
V
E
Y
I
A
V
N
T
D
A
Q
A
L
N
L
S
K
A
E
V
K
M
Q
I
G
A
K
L
T
R
G
L
G
A
G
A
N
P
E
V
G
K
K
A
A
E
E
S
K
E
Q
I
E
E
A
L
K
G
A
D
M
V
F
V
T
A
G
M
G
G
G
T
G
T
G
A
A
P
V
I
A
Q
I
A
K
D
L
G
A
L
T
V
G
V
V
T
R
P
F
T
F
E
G
R
K
R
Q
L
Q
A
A
G
G
I
S
A
M
K
E
A
V
D
T
L
I
V
I
P
N
D
R
I
L
E
I
V
D
K
N
T
P
M
L
E
A
F
R
E
A
D
N
V
L
R
Q
G
V
Q
G
I
S
D
L
I
A
------
L
--
D
--
F
A
D
V
K
T
I
M
--
K
G
S
A
L
M
G
I
G
I
A
T
G
E
N
R
A
A
E
A
A
K
K
A
I
S
S
P
L
L
E
-
A
A
I
D
G
A
Q
G
V
L
M
N
I
T
G
G
T
N
L
S
L
Y
E
V
Q
E
A
A
D
I
V
A
S
A
S
D
Q
D
V
N
M
I
F
G
S
V
I
N
E
N
L
-
K
D
E
I
V
V
T
V
I
A
T
G
---------------------------------------------------------------------------------------------------------
61
PsiBlast_CBE
89.91
50%
-111
- C3 -
-
1W5E
1
FTSZ1_METJA
E:
[38-345]
---------------
A
K
I
T
V
V
G
C
G
G
A
G
N
N
T
I
T
R
L
K
M
E
G
I
E
G
A
K
T
V
A
I
N
T
D
A
Q
Q
L
I
R
T
K
A
D
K
K
I
L
I
G
K
K
L
T
R
G
L
G
A
G
G
N
P
K
I
G
E
E
A
A
K
E
S
A
E
E
I
K
A
A
I
Q
D
S
D
M
V
F
I
T
C
G
L
G
G
G
T
G
T
G
S
A
P
V
V
A
E
I
S
K
K
I
G
A
L
T
V
A
V
V
T
L
P
F
V
M
E
G
K
V
R
M
K
N
A
M
E
G
L
E
R
L
K
Q
H
T
D
T
L
V
V
I
P
N
E
K
L
F
E
I
V
-
P
N
M
P
L
K
L
A
F
K
V
A
D
E
V
L
I
N
A
V
K
G
L
V
E
L
I
T
K
D
G
L
I
N
V
--
D
--
F
A
D
V
K
A
V
M
N
N
G
G
L
A
M
I
G
I
G
E
S
D
S
E
K
R
A
K
E
A
V
S
M
A
L
N
S
P
L
L
D
-
V
D
I
D
G
A
T
G
A
L
I
H
V
M
G
P
E
D
L
T
L
E
E
A
R
E
V
V
A
T
V
S
S
R
L
D
P
N
A
T
I
I
Y
G
A
T
I
D
E
N
L
-
E
N
T
V
R
V
L
L
V
I
T
G
-
V
-
Q
S
R
I
E
-------------------------------------------------------------------------------------------------
64
PsiBlast_CBE
89.88
50%
-110
- C3 -
-
1W5E
1
FTSZ1_METJA
B:
[38-345]
---------------
A
K
I
T
V
V
G
C
G
G
A
G
N
N
T
I
T
R
L
K
M
E
G
I
E
G
A
K
T
V
A
I
N
T
D
A
Q
Q
L
I
R
T
K
A
D
K
K
I
L
I
G
K
K
L
T
R
G
L
G
A
G
G
N
P
K
I
G
E
E
A
A
K
E
S
A
E
E
I
K
A
A
I
Q
D
S
D
M
V
F
I
T
C
G
L
G
G
G
T
G
T
G
S
A
P
V
V
A
E
I
S
K
K
I
G
A
L
T
V
A
V
V
T
L
P
F
V
M
E
G
K
V
R
M
K
N
A
M
E
G
L
E
R
L
K
Q
H
T
D
T
L
V
V
I
P
N
E
K
L
F
E
I
V
-
P
N
M
P
L
K
L
A
F
K
V
A
D
E
V
L
I
N
A
V
K
G
L
V
E
L
I
T
K
D
G
L
I
N
V
--
D
--
F
A
D
V
K
A
V
M
N
N
G
G
L
A
M
I
G
I
G
E
S
D
S
E
K
R
A
K
E
A
V
S
M
A
L
N
S
P
L
L
D
-
V
D
I
D
G
A
T
G
A
L
I
H
V
M
G
P
E
D
L
T
L
E
E
A
R
E
V
V
A
T
V
S
S
R
L
D
P
N
A
T
I
I
Y
G
A
T
I
D
E
N
L
-
E
N
T
V
R
V
L
L
V
I
T
G
-
V
-
Q
S
R
I
E
-------------------------------------------------------------------------------------------------
67
PsiBlast_CBE
89.85
50%
-112
- C3 -
-
1W5B
1
FTSZ1_METJA
B:
[38-345]
---------------
A
K
I
T
V
V
G
C
G
G
A
G
N
N
T
I
T
R
L
K
M
E
G
I
E
G
A
K
T
V
A
I
N
T
D
A
Q
Q
L
I
R
T
K
A
D
K
K
I
L
I
G
K
K
L
T
R
G
L
G
A
G
G
N
P
K
I
G
E
E
A
A
K
E
S
A
E
E
I
K
A
A
I
Q
D
S
D
M
V
F
I
T
C
G
L
G
G
G
T
G
T
G
S
A
P
V
V
A
E
I
S
K
K
I
G
A
L
T
V
A
V
V
T
L
P
F
V
M
E
G
K
V
R
M
K
N
A
M
E
G
L
E
R
L
K
Q
H
T
D
T
L
V
V
I
P
N
E
K
L
F
E
I
V
-
P
N
M
P
L
K
L
A
F
K
V
A
D
E
V
L
I
N
A
V
K
G
L
V
E
L
I
T
K
D
G
L
I
N
V
--
D
--
F
A
D
V
K
A
V
M
N
N
G
G
L
A
M
I
G
I
G
E
S
D
S
E
K
R
A
K
E
A
V
S
M
A
L
N
S
P
L
L
D
-
V
D
I
D
G
A
T
G
A
L
I
H
V
M
G
P
E
D
L
T
L
E
E
A
R
E
V
V
A
T
V
S
S
R
L
D
P
N
A
T
I
I
W
G
A
T
I
D
E
N
L
-
E
N
T
V
R
V
L
L
V
I
T
G
-
V
-
Q
S
R
I
E
-------------------------------------------------------------------------------------------------
66
PsiBlast_CBE
89.85
50%
-119
* C3 *
-
2VAP
1
FTSZ1_METJA
A:
[38-345]
---------------
A
K
I
T
V
V
G
C
G
G
A
G
N
N
T
I
T
R
L
K
M
E
G
I
E
G
A
K
T
V
A
I
N
T
D
A
Q
Q
L
I
R
T
K
A
D
K
K
I
L
I
G
K
K
L
T
R
G
L
G
A
G
G
N
P
K
I
G
E
E
A
A
K
E
S
A
E
E
I
K
A
A
I
Q
D
S
D
M
V
F
I
T
C
G
L
G
G
G
T
G
T
G
S
A
P
V
V
A
E
I
S
K
K
I
G
A
L
T
V
A
V
V
T
L
P
F
V
M
E
G
K
V
R
M
K
N
A
M
E
G
L
E
R
L
K
Q
H
T
D
T
L
V
V
I
P
N
E
K
L
F
E
I
V
-
P
N
M
P
L
K
L
A
F
K
V
A
D
E
V
L
I
N
A
V
K
G
L
V
E
L
I
T
K
D
G
L
I
N
V
--
D
--
F
A
D
V
K
A
V
M
N
N
G
G
L
A
M
I
G
I
G
E
S
D
S
E
K
R
A
K
E
A
V
S
M
A
L
N
S
P
L
L
D
-
V
D
I
D
G
A
T
G
A
L
I
H
V
M
G
P
E
D
L
T
L
E
E
A
R
E
V
V
A
T
V
S
S
R
L
D
P
N
A
T
I
I
W
G
A
T
I
D
E
N
L
-
E
N
T
V
R
V
L
L
V
I
T
G
-
V
-
Q
S
R
I
E
-------------------------------------------------------------------------------------------------
81
HHSearch
89.62
57%
-93
- C3 -
-
1OFU
1
FTSZ_PSEAE
B:
[11-317]
--------------
T
A
V
I
K
V
I
G
V
G
G
G
G
G
N
A
V
N
H
M
A
K
N
N
V
E
G
V
E
F
I
C
A
N
T
D
A
Q
A
L
K
N
I
A
A
R
T
V
L
Q
L
G
P
G
V
T
K
G
L
G
A
G
A
N
P
E
V
G
R
Q
A
A
L
E
D
R
E
R
I
S
E
V
L
E
G
A
D
M
V
F
I
T
T
G
M
G
G
G
T
G
T
G
A
A
P
I
I
A
E
V
A
K
E
M
G
I
L
T
V
A
V
V
T
R
P
F
P
F
E
G
R
K
R
M
Q
I
A
D
E
G
I
R
A
L
A
E
S
V
D
S
L
I
T
I
P
N
E
K
L
L
T
I
L
G
K
D
A
S
L
L
A
A
F
A
K
A
D
D
V
L
A
G
A
V
R
G
I
S
D
I
I
K
R
P
G
M
I
N
V
--
D
--
F
A
D
V
K
T
V
M
S
E
M
G
M
A
M
M
G
T
G
C
A
S
G
P
N
R
A
R
E
A
T
E
A
A
I
R
N
P
L
L
E
D
V
N
L
Q
G
A
R
G
I
L
V
N
I
T
A
G
P
D
L
S
L
G
E
Y
S
D
V
G
N
I
I
E
Q
F
A
S
E
H
A
T
V
K
V
G
T
V
I
D
A
D
M
-
R
D
E
L
H
V
T
V
V
A
T
G
-
L
G
------------------------------------------------------------------------------------------------------
84
HHSearch
89.44
49%
-116
- C3 -
-
2VAP
1
FTSZ1_METJA
A:
[34-347]
-----------
Q
Q
T
K
A
K
I
T
V
V
G
C
G
G
A
G
N
N
T
I
T
R
L
K
M
E
G
I
E
G
A
K
T
V
A
I
N
T
D
A
Q
Q
L
I
R
T
K
A
D
K
K
I
L
I
G
K
K
L
T
R
G
L
G
A
G
G
N
P
K
I
G
E
E
A
A
K
E
S
A
E
E
I
K
A
A
I
Q
D
S
D
M
V
F
I
T
C
G
L
G
G
G
T
G
T
G
S
A
P
V
V
A
E
I
S
K
K
I
G
A
L
T
V
A
V
V
T
L
P
F
V
M
E
G
K
V
R
M
K
N
A
M
E
G
L
E
R
L
K
Q
H
T
D
T
L
V
V
I
P
N
E
K
L
F
E
I
V
P
-
N
M
P
L
K
L
A
F
K
V
A
D
E
V
L
I
N
A
V
K
G
L
V
E
L
I
T
K
D
G
L
I
N
V
--
D
--
F
A
D
V
K
A
V
M
N
N
G
G
L
A
M
I
G
I
G
E
S
D
S
E
K
R
A
K
E
A
V
S
M
A
L
N
S
P
L
L
D
-
V
D
I
D
G
A
T
G
A
L
I
H
V
M
G
P
E
D
L
T
L
E
E
A
R
E
V
V
A
T
V
S
S
R
L
D
P
N
A
T
I
I
W
G
A
T
I
D
E
N
L
-
E
N
T
V
R
V
L
L
V
I
T
G
-
V
Q
S
R
I
E
F
T
------------------------------------------------------------------------------------------------
73
PsiBlast_CBE
89.18
50%
-114
- C3 -
-
1FSZ
1
FTSZ1_METJA
A:
[38-345]
---------------
A
K
I
T
V
V
G
C
G
G
A
G
N
N
T
I
T
R
L
K
M
E
G
I
E
G
A
K
T
V
A
I
N
T
D
A
Q
Q
L
I
R
T
K
A
D
K
K
I
L
I
G
K
K
L
T
R
G
L
G
A
G
G
N
P
K
I
G
E
E
A
A
K
E
S
A
E
E
I
K
A
A
I
Q
D
S
D
M
V
F
I
T
C
G
L
G
G
G
T
G
T
G
S
A
P
V
V
A
E
I
S
K
K
I
G
A
L
T
V
A
V
V
T
L
P
F
V
M
E
G
K
V
R
M
K
N
A
M
E
G
L
E
R
L
K
Q
H
T
D
T
L
V
V
I
P
N
E
K
L
F
E
I
V
-
P
N
M
P
L
K
L
A
F
K
V
A
D
E
V
L
I
N
A
V
K
G
L
V
E
L
I
T
K
D
G
L
I
N
V
--
D
--
F
A
D
V
K
A
V
M
N
N
G
G
L
A
M
I
G
I
G
E
S
D
S
E
K
R
A
K
E
A
V
S
M
A
L
N
S
P
L
L
D
-
V
D
I
D
G
A
T
G
A
L
I
H
V
M
G
P
E
D
L
T
L
E
E
A
R
E
V
V
A
T
V
S
S
R
L
D
P
N
A
T
I
I
W
G
A
T
I
D
E
N
L
-
E
N
T
V
R
V
L
L
V
I
T
G
-
V
-
Q
S
R
I
E
-------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
88.41
66%
-108
- C3 -
-
2RHL
1
FTSZ_BACSU
A:
[19-306]
--------------------------------
R
M
I
E
N
E
V
Q
G
V
E
Y
I
A
V
N
T
D
A
Q
A
L
N
L
S
K
A
E
V
K
M
Q
I
G
A
K
L
T
R
G
L
G
A
G
A
N
P
E
V
G
K
K
A
A
E
E
S
K
E
Q
I
E
E
A
L
K
G
A
D
M
V
F
V
T
A
G
M
G
G
G
T
G
T
G
A
A
P
V
I
A
Q
I
A
K
D
L
G
A
L
T
V
G
V
V
T
R
P
F
T
F
E
G
R
K
R
Q
L
Q
A
A
G
G
I
S
A
M
K
E
A
V
D
T
L
I
V
I
P
N
D
R
I
L
E
I
V
D
K
N
T
P
M
L
E
A
F
R
E
A
D
N
V
L
R
Q
G
V
Q
G
I
S
D
L
I
A
T
P
G
L
I
N
L
--
D
--
F
A
D
V
K
T
I
M
S
N
K
G
S
A
L
M
G
I
G
I
A
T
G
E
N
R
A
A
E
A
A
K
K
A
I
S
S
P
L
L
E
-
A
A
I
D
G
A
Q
G
V
L
M
N
I
T
G
G
T
N
L
S
L
Y
E
V
Q
E
A
A
D
I
V
A
S
A
S
D
Q
D
V
N
M
I
F
G
S
V
I
N
E
N
L
-
K
D
E
I
V
V
T
V
I
A
T
G
-
F
L
------------------------------------------------------------------------------------------------------
25
PsiBlast_CBE
87.99
66%
-99
- C3 -
-
2RHL
1
FTSZ_BACSU
B:
[19-308]
--------------------------------
R
M
I
E
N
E
V
Q
G
V
E
Y
I
A
V
N
T
D
A
Q
A
L
N
L
S
K
A
E
V
K
M
Q
I
G
A
K
L
T
R
G
L
G
A
G
A
N
P
E
V
G
K
K
A
A
E
E
S
K
E
Q
I
E
E
A
L
K
G
A
D
M
V
F
V
T
A
G
M
G
G
G
T
G
T
G
A
A
P
V
I
A
Q
I
A
K
D
L
G
A
L
T
V
G
V
V
T
R
P
F
T
F
E
G
R
K
R
Q
L
Q
A
A
G
G
I
S
A
M
K
E
A
V
D
T
L
I
V
I
P
N
D
R
I
L
E
I
V
D
K
N
T
P
M
L
E
A
F
R
E
A
D
N
V
L
R
Q
G
V
Q
G
I
S
D
L
I
A
T
P
G
L
I
N
L
--
D
--
F
A
D
V
K
T
I
M
S
N
K
G
S
A
L
M
G
I
G
I
A
T
G
E
N
R
A
A
E
A
A
K
K
A
I
S
S
P
L
L
E
-
A
A
I
D
G
A
Q
G
V
L
M
N
I
T
G
G
T
N
L
S
L
Y
E
V
Q
E
A
A
D
I
V
A
S
A
S
D
Q
D
V
N
M
I
F
G
S
V
I
N
E
N
L
-
K
D
E
I
V
V
T
V
I
A
T
G
-
F
L
E
N
----------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
87.69
64%
-104
- C3 -
-
4DXD
2
FTSZ_STAAU
A:
[35-320]
--------------------------------
R
M
I
D
H
G
M
N
N
V
E
F
I
A
I
N
T
D
G
Q
A
L
N
L
S
K
A
E
S
K
I
Q
I
G
E
K
L
T
R
G
L
G
A
G
A
N
P
E
I
G
K
K
A
A
E
E
S
R
E
Q
I
E
D
A
I
Q
G
A
D
M
V
F
V
T
S
G
M
G
G
G
T
G
T
G
A
A
P
V
V
A
K
I
A
K
E
M
G
A
L
T
V
G
V
V
T
R
P
F
S
F
E
G
R
K
R
Q
T
Q
A
A
A
G
V
E
A
M
K
A
A
V
D
T
L
I
V
I
P
N
D
R
L
L
D
I
V
D
K
S
T
P
M
M
E
A
F
K
E
A
D
N
V
L
R
Q
G
V
Q
G
I
S
D
L
I
A
V
S
G
E
V
N
L
--
D
--
F
A
D
V
K
T
I
M
S
N
Q
G
S
A
L
M
G
I
G
V
S
S
G
E
N
R
A
V
E
A
A
K
K
A
I
S
S
P
L
L
E
-
T
S
I
V
G
A
Q
G
V
L
M
N
I
T
G
G
E
S
L
S
L
F
E
A
Q
E
A
A
D
I
V
Q
D
A
A
D
E
D
V
N
M
I
F
G
T
V
I
N
P
E
L
-
Q
D
E
I
V
V
T
V
I
A
T
G
---------------------------------------------------------------------------------------------------------
28
PsiBlast_CBE
87.60
64%
-101
- C3 -
-
3VO8
1
FTSZ_STAAM
B:
[31-316]
--------------------------------
R
M
I
D
H
G
M
N
N
V
E
F
I
A
I
N
T
D
G
Q
A
L
N
L
S
K
A
E
S
K
I
Q
I
G
E
K
L
T
R
G
L
G
A
G
A
N
P
E
I
G
K
K
A
A
E
E
S
R
E
Q
I
E
D
A
I
Q
G
A
D
M
V
F
V
T
S
G
M
G
G
G
T
G
T
G
A
A
P
V
V
A
K
I
A
K
E
M
G
A
L
T
V
G
V
V
T
R
P
F
S
F
E
G
R
K
R
Q
T
Q
A
A
A
G
V
E
A
M
K
A
A
V
D
T
L
I
V
I
P
N
D
R
L
L
D
I
V
D
K
S
T
P
M
M
E
A
F
K
E
A
D
N
V
L
R
Q
G
V
Q
G
I
S
D
L
I
A
V
S
G
E
V
N
L
--
D
--
F
A
D
V
K
T
I
M
S
N
Q
G
S
A
L
M
G
I
G
V
S
S
G
E
N
R
A
V
E
A
A
K
K
A
I
S
S
P
L
L
E
-
T
S
I
V
G
A
Q
G
V
L
M
N
I
T
G
G
E
S
L
S
L
F
E
A
Q
E
A
A
D
I
V
Q
D
A
A
D
E
D
V
N
M
I
F
G
T
V
I
N
P
E
L
-
Q
D
E
I
V
V
T
V
I
A
T
G
---------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
87.60
64%
-97
- C3 -
-
3VOA
1
FTSZ_STAAM
A:
[21-306]
--------------------------------
R
M
I
D
H
G
M
N
N
V
E
F
I
A
I
N
T
D
G
Q
A
L
N
L
S
K
A
E
S
K
I
Q
I
G
E
K
L
T
R
G
L
G
A
G
A
N
P
E
I
G
K
K
A
A
E
E
S
R
E
Q
I
E
D
A
I
Q
G
A
D
M
V
F
V
T
S
G
M
G
G
G
T
G
T
G
A
A
P
V
V
A
K
I
A
K
E
M
G
A
L
T
V
G
V
V
T
R
P
F
S
F
E
G
R
K
R
Q
T
Q
A
A
A
G
V
E
A
M
K
A
A
V
D
T
L
I
V
I
P
N
D
R
L
L
D
I
V
D
K
S
T
P
M
M
E
A
F
K
E
A
D
N
V
L
R
Q
G
V
Q
G
I
S
D
L
I
A
V
S
G
E
V
N
L
--
D
--
F
A
D
V
K
T
I
M
S
N
Q
G
S
A
L
M
G
I
G
V
S
S
G
E
N
R
A
V
E
A
A
K
K
A
I
S
S
P
L
L
E
-
T
S
I
V
G
A
Q
G
V
L
M
N
I
T
G
G
E
S
L
S
L
F
E
A
Q
E
A
A
D
I
V
Q
D
A
A
D
E
D
V
N
M
I
F
G
T
V
I
N
P
E
L
-
Q
D
E
I
V
V
T
V
I
A
T
G
---------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
87.52
64%
-98
- C3 -
-
3VO8
1
FTSZ_STAAM
A:
[31-316]
--------------------------------
R
M
I
D
H
G
M
N
N
V
E
F
I
A
I
N
T
D
G
Q
A
L
N
L
S
K
A
E
S
K
I
Q
I
G
E
K
L
T
R
G
L
G
A
G
A
N
P
E
I
G
K
K
A
A
E
E
S
R
E
Q
I
E
D
A
I
Q
G
A
D
M
V
F
V
T
S
G
M
G
G
G
T
G
T
G
A
A
P
V
V
A
K
I
A
K
E
M
G
A
L
T
V
G
V
V
T
R
P
F
S
F
E
G
R
K
R
Q
T
Q
A
A
A
G
V
E
A
M
K
A
A
V
D
T
L
I
V
I
P
N
D
R
L
L
D
I
V
D
K
S
T
P
M
M
E
A
F
K
E
A
D
N
V
L
R
Q
G
V
Q
G
I
S
D
L
I
A
V
S
G
E
V
N
L
--
D
--
F
A
D
V
K
T
I
M
S
N
Q
G
S
A
L
M
G
I
G
V
S
S
G
E
N
R
A
V
E
A
A
K
K
A
I
S
S
P
L
L
E
-
T
S
I
V
G
A
Q
G
V
L
M
N
I
T
G
G
E
S
L
S
L
F
E
A
Q
E
A
A
D
I
V
Q
D
A
A
D
E
D
V
N
M
I
F
G
T
V
I
N
P
E
L
-
Q
D
E
I
V
V
T
V
I
A
T
G
---------------------------------------------------------------------------------------------------------
35
PsiBlast_CBE
87.23
63%
-103
- C3 -
-
3WGL
1
FTSZ_STAAM
B:
[31-314]
--------------------------------
R
M
I
D
H
G
M
N
N
V
E
F
I
A
I
N
T
D
G
Q
A
L
N
L
S
K
A
E
S
K
I
Q
I
G
E
K
L
T
R
G
L
G
A
G
A
N
P
E
I
G
K
K
A
A
E
E
S
R
E
Q
I
E
D
A
I
Q
G
A
D
M
V
F
V
T
S
G
M
G
G
G
T
G
T
G
A
A
P
V
V
A
K
I
A
K
E
M
G
A
L
T
V
G
V
V
T
R
P
F
S
F
E
G
R
K
R
Q
T
Q
A
A
A
G
V
E
A
M
K
A
A
V
D
T
L
I
V
I
P
N
D
R
L
L
D
I
V
D
K
S
T
P
M
M
E
A
F
K
E
A
D
N
V
L
R
Q
G
V
Q
G
I
S
D
L
I
A
V
G
A
--
N
L
--
D
--
F
A
D
V
K
T
I
M
S
N
Q
G
S
A
L
M
G
I
G
V
S
S
G
E
N
R
A
V
E
A
A
K
K
A
I
S
S
P
L
L
E
-
T
S
I
V
G
A
Q
G
V
L
M
N
I
T
G
G
E
S
L
S
L
F
E
A
Q
E
A
A
D
I
V
Q
D
A
A
D
E
D
V
N
M
I
F
G
T
V
I
N
P
E
L
-
Q
D
E
I
V
V
T
V
I
A
T
G
---------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
87.16
66%
-105
- C3 -
-
2RHO
1
FTSZ_BACSU
A:
[19-306]
--------------------------------
R
M
I
E
N
E
V
Q
G
V
E
Y
I
A
V
N
T
D
A
Q
A
L
N
L
S
K
A
E
V
K
M
Q
I
G
A
K
L
T
R
G
L
G
A
G
A
N
P
E
V
G
K
K
A
A
E
E
S
K
E
Q
I
E
E
A
L
K
G
A
D
M
V
F
V
T
A
G
M
G
G
G
T
G
T
G
A
A
P
V
I
A
Q
I
A
K
D
L
G
A
L
T
V
G
V
V
T
R
P
F
T
F
E
G
R
K
R
Q
L
Q
A
A
G
G
I
S
A
M
K
E
A
V
D
T
L
I
V
I
P
N
D
R
I
L
E
I
V
D
K
N
T
P
M
L
E
A
F
R
E
A
D
N
V
L
R
Q
G
V
Q
G
I
S
D
L
I
A
T
P
G
L
I
N
L
--
D
--
F
A
D
V
K
T
I
M
S
N
K
G
S
A
L
M
G
I
G
I
A
T
G
E
N
R
A
A
E
A
A
K
K
A
I
S
S
P
L
L
E
-
A
A
I
D
G
A
Q
G
V
L
M
N
I
T
G
G
T
N
L
S
L
Y
E
V
Q
E
A
A
D
I
V
A
S
A
S
D
Q
D
V
N
M
I
F
G
S
V
I
N
E
N
L
-
K
D
E
I
V
V
T
V
I
A
T
G
-
F
L
------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
87.00
64%
-101
- C3 -
-
5H5G
1
?
A:
[21-306]
--------------------------------
R
M
I
D
H
G
M
N
N
V
E
F
I
A
I
N
T
D
G
Q
A
L
N
L
S
K
A
E
S
K
I
Q
I
G
E
K
L
T
R
G
L
G
A
G
A
N
P
E
I
G
K
K
A
A
E
E
S
R
E
Q
I
E
D
A
I
Q
G
A
D
M
V
F
V
T
S
G
M
G
G
G
T
G
T
G
A
A
P
V
V
A
K
I
A
K
E
M
G
A
L
T
V
G
V
V
T
R
P
F
S
F
E
G
R
K
R
Q
T
Q
A
A
A
G
V
E
A
M
K
A
A
V
D
T
L
I
V
I
P
N
D
R
L
L
D
I
V
D
K
S
T
P
M
M
E
A
F
K
E
A
D
N
V
L
R
Q
G
V
Q
G
I
S
D
L
I
A
V
S
G
E
V
N
L
--
D
--
F
A
D
V
K
T
I
M
S
N
Q
G
S
A
L
M
G
I
G
V
S
S
G
E
N
R
A
V
E
A
A
K
K
A
I
S
S
P
L
L
E
-
T
S
I
V
G
A
Q
G
V
L
M
N
I
T
G
G
E
S
L
S
L
F
E
A
Q
E
A
A
D
I
V
Q
D
A
A
D
E
D
V
N
M
I
F
G
T
V
I
N
P
E
L
-
Q
D
E
I
V
V
T
V
I
A
T
G
---------------------------------------------------------------------------------------------------------
34
PsiBlast_CBE
86.79
63%
-101
- C3 -
-
3WGM
1
FTSZ_STAAM
A:
[31-314]
--------------------------------
R
M
I
D
H
G
M
N
N
V
E
F
I
A
I
N
T
D
G
Q
A
L
N
L
S
K
A
E
S
K
I
Q
I
G
E
K
L
T
R
G
L
G
A
G
A
N
P
E
I
G
K
K
A
A
E
E
S
R
E
Q
I
E
D
A
I
Q
G
A
D
M
V
F
V
T
S
G
M
G
G
G
T
G
T
G
A
A
P
V
V
A
K
I
A
K
E
M
G
A
L
T
V
G
V
V
T
R
P
F
S
F
E
G
R
K
R
Q
T
Q
A
A
A
G
V
E
A
M
K
A
A
V
D
T
L
I
V
I
P
N
D
R
L
L
D
I
V
D
K
S
T
P
M
M
E
A
F
K
E
A
D
N
V
L
R
Q
G
V
Q
G
I
S
D
L
I
A
V
G
A
--
N
L
--
D
--
F
A
D
V
K
T
I
M
S
N
Q
G
S
A
L
M
G
I
G
V
S
S
G
E
N
R
A
V
E
A
A
K
K
A
I
S
S
P
L
L
E
-
T
S
I
V
G
A
Q
G
V
L
M
N
I
T
G
G
E
S
L
S
L
F
E
A
Q
E
A
A
D
I
V
Q
D
A
A
D
E
D
V
N
M
I
F
G
T
V
I
N
P
E
L
-
Q
D
E
I
V
V
T
V
I
A
T
G
---------------------------------------------------------------------------------------------------------
24
PsiBlast_CBE
86.60
66%
-104
- C3 -
-
2RHO
1
FTSZ_BACSU
B:
[19-305]
--------------------------------
R
M
I
E
N
E
V
Q
G
V
E
Y
I
A
V
N
T
D
A
Q
A
L
N
L
S
K
A
E
V
K
M
Q
I
G
A
K
L
T
R
G
L
G
A
G
A
N
P
E
V
G
K
K
A
A
E
E
S
K
E
Q
I
E
E
A
L
K
G
A
D
M
V
F
V
T
A
G
M
G
G
G
T
G
T
G
A
A
P
V
I
A
Q
I
A
K
D
L
G
A
L
T
V
G
V
V
T
R
P
F
T
F
E
G
R
K
R
Q
L
Q
A
A
G
G
I
S
A
M
K
E
A
V
D
T
L
I
V
I
P
N
D
R
I
L
E
I
V
D
K
N
T
P
M
L
E
A
F
R
E
A
D
N
V
L
R
Q
G
V
Q
G
I
S
D
L
I
A
T
P
G
L
I
N
L
--
D
--
F
A
D
V
K
T
I
M
S
N
--
S
A
L
M
G
I
G
I
A
T
G
E
N
R
A
A
E
A
A
K
K
A
I
S
S
P
L
L
E
-
A
A
I
D
G
A
Q
G
V
L
M
N
I
T
G
G
T
N
L
S
L
Y
E
V
Q
E
A
A
D
I
V
A
S
A
S
D
Q
D
V
N
M
I
F
G
S
V
I
N
E
N
L
-
K
D
E
I
V
V
T
V
I
A
T
G
-
F
-------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
86.49
60%
-95
- C3 -
-
4M8I
1
FTSZ_STAEQ
A:
[35-327]
--------------------------------
R
M
I
D
H
G
M
N
N
V
E
F
I
A
I
N
T
D
G
Q
A
L
N
L
S
K
A
E
S
K
I
Q
I
G
E
K
L
T
R
G
L
G
A
G
A
N
P
E
I
G
K
K
A
A
E
E
S
R
E
Q
I
E
D
A
I
Q
G
A
D
M
V
F
V
T
A
G
M
G
G
G
T
G
T
G
A
A
P
V
V
A
K
I
A
K
E
M
G
A
L
T
V
G
V
V
T
R
P
F
G
F
E
G
R
K
R
Q
T
Q
A
A
A
G
V
E
S
M
K
A
A
V
D
T
L
I
V
I
P
N
D
R
L
L
D
I
V
D
K
S
T
P
M
M
E
A
F
K
E
A
D
N
V
L
R
Q
G
V
Q
G
I
S
D
L
I
A
V
S
G
E
V
N
L
--
D
--
F
A
D
V
K
T
I
M
S
N
Q
G
S
A
L
M
G
I
G
V
S
S
G
E
N
R
A
V
E
A
A
K
K
A
I
S
S
P
L
L
E
-
T
S
I
V
G
A
Q
G
V
L
M
N
I
T
G
G
E
S
L
S
L
F
E
A
Q
E
A
A
D
I
V
Q
D
A
A
D
E
D
V
N
M
I
F
G
T
V
I
N
P
E
L
-
Q
D
E
I
V
V
T
V
I
A
T
G
------
F
E
D
K
P
S
S
--------------------------------------------------------------------------------------------
19
PsiBlast_PDB
86.40
63%
-98
- C3 -
-
5MN4
2
FTSZ_STAAU
A:
[18-303]
--------------------------------
R
M
I
D
H
G
M
N
N
V
E
F
I
A
I
N
T
D
G
Q
A
L
N
L
S
K
A
E
S
K
I
Q
I
G
E
K
L
T
R
G
L
G
A
G
A
N
P
E
I
G
K
K
A
A
E
E
S
R
E
Q
I
E
D
A
I
Q
G
A
D
M
V
F
V
T
S
G
M
G
G
G
T
G
T
G
A
A
P
V
V
A
K
I
A
K
E
M
G
A
L
T
V
G
V
V
T
R
P
F
S
A
E
G
R
K
R
Q
T
Q
A
A
A
G
V
E
A
M
K
A
A
V
D
T
L
I
V
I
P
N
D
R
L
L
D
I
V
D
K
S
T
P
M
M
E
A
F
K
E
A
D
N
V
L
R
Q
G
V
Q
G
I
S
D
L
I
A
V
S
G
E
V
N
L
--
D
--
F
A
D
V
K
T
I
M
S
N
Q
G
S
A
L
M
G
I
G
V
S
S
G
E
N
R
A
V
E
A
A
K
K
A
I
S
S
P
L
L
E
-
T
S
I
V
G
A
Q
G
V
L
M
N
I
T
G
G
E
S
L
S
L
F
E
A
Q
E
A
A
D
I
V
Q
D
A
A
D
E
D
V
N
M
I
F
G
T
V
I
N
P
E
L
-
Q
D
E
I
V
V
T
V
I
A
T
G
---------------------------------------------------------------------------------------------------------
29
PsiBlast_CBE
86.38
64%
-104
- C3 -
-
5H5G
1
?
B:
[21-306]
--------------------------------
R
M
I
D
H
G
M
N
N
V
E
F
I
A
I
N
T
D
G
Q
A
L
N
L
S
K
A
E
S
K
I
Q
I
G
E
K
L
T
R
G
L
G
A
G
A
N
P
E
I
G
K
K
A
A
E
E
S
R
E
Q
I
E
D
A
I
Q
G
A
D
M
V
F
V
T
S
G
M
G
G
G
T
G
T
G
A
A
P
V
V
A
K
I
A
K
E
M
G
A
L
T
V
G
V
V
T
R
P
F
S
F
E
G
R
K
R
Q
T
Q
A
A
A
G
V
E
A
M
K
A
A
V
D
T
L
I
V
I
P
N
D
R
L
L
D
I
V
D
K
S
T
P
M
M
E
A
F
K
E
A
D
N
V
L
R
Q
G
V
Q
G
I
S
D
L
I
A
V
S
G
E
V
N
L
--
D
--
F
A
D
V
K
T
I
M
S
N
Q
G
S
A
L
M
G
I
G
V
S
S
G
E
N
R
A
V
E
A
A
K
K
A
I
S
S
P
L
L
E
-
T
S
I
V
G
A
Q
G
V
L
M
N
I
T
G
G
E
S
L
S
L
F
E
A
Q
E
A
A
D
I
V
Q
D
A
A
D
E
D
V
N
M
I
F
G
T
V
I
N
P
E
L
-
Q
D
E
I
V
V
T
V
I
A
T
G
---------------------------------------------------------------------------------------------------------
37
PsiBlast_CBE
86.33
63%
-103
- C3 -
-
3WGK
1
FTSZ_STAAM
B:
[31-314]
--------------------------------
R
M
I
D
H
G
M
N
N
V
E
F
I
A
I
N
T
D
G
Q
A
L
N
L
S
K
A
E
S
K
I
Q
I
G
E
K
L
T
R
G
L
G
A
G
A
N
P
E
I
G
K
K
A
A
E
E
S
R
E
Q
I
E
D
A
I
Q
G
A
D
M
V
F
V
T
S
G
M
G
G
G
T
G
T
G
A
A
P
V
V
A
K
I
A
K
E
M
G
A
L
T
V
G
V
V
T
R
P
F
S
F
E
G
R
K
R
Q
T
Q
A
A
A
G
V
E
A
M
K
A
A
V
D
T
L
I
V
I
P
N
D
R
L
L
D
I
V
D
K
S
T
P
M
M
E
A
F
K
E
A
D
N
V
L
R
Q
G
V
Q
G
I
S
D
L
I
A
V
G
A
--
G
L
--
D
--
F
A
D
V
K
T
I
M
S
N
Q
G
S
A
L
M
G
I
G
V
S
S
G
E
N
R
A
V
E
A
A
K
K
A
I
S
S
P
L
L
E
-
T
S
I
V
G
A
Q
G
V
L
M
N
I
T
G
G
E
S
L
S
L
F
E
A
Q
E
A
A
D
I
V
Q
D
A
A
D
E
D
V
N
M
I
F
G
T
V
I
N
P
E
L
-
Q
D
E
I
V
V
T
V
I
A
T
G
---------------------------------------------------------------------------------------------------------
33
PsiBlast_CBE
86.12
63%
-98
- C3 -
-
3WGM
1
FTSZ_STAAM
B:
[31-314]
--------------------------------
R
M
I
D
H
G
M
N
N
V
E
F
I
A
I
N
T
D
G
Q
A
L
N
L
S
K
A
E
S
K
I
Q
I
G
E
K
L
T
R
G
L
G
A
G
A
N
P
E
I
G
K
K
A
A
E
E
S
R
E
Q
I
E
D
A
I
Q
G
A
D
M
V
F
V
T
S
G
M
G
G
G
T
G
T
G
A
A
P
V
V
A
K
I
A
K
E
M
G
A
L
T
V
G
V
V
T
R
P
F
S
F
E
G
R
K
R
Q
T
Q
A
A
A
G
V
E
A
M
K
A
A
V
D
T
L
I
V
I
P
N
D
R
L
L
D
I
V
D
K
S
T
P
M
M
E
A
F
K
E
A
D
N
V
L
R
Q
G
V
Q
G
I
S
D
L
I
A
V
G
A
--
N
L
--
D
--
F
A
D
V
K
T
I
M
S
N
Q
G
S
A
L
M
G
I
G
V
S
S
G
E
N
R
A
V
E
A
A
K
K
A
I
S
S
P
L
L
E
-
T
S
I
V
G
A
Q
G
V
L
M
N
I
T
G
G
E
S
L
S
L
F
E
A
Q
E
A
A
D
I
V
Q
D
A
A
D
E
D
V
N
M
I
F
G
T
V
I
N
P
E
L
-
Q
D
E
I
V
V
T
V
I
A
T
G
---------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
85.93
64%
-96
- C3 -
-
3VOB
2
FTSZ_STAAM
A:
[21-306]
--------------------------------
R
M
I
D
H
G
M
N
N
V
E
F
I
A
I
N
T
D
G
Q
A
L
N
L
S
K
A
E
S
K
I
Q
I
G
E
K
L
T
R
G
L
G
A
G
A
N
P
E
I
G
K
K
A
A
E
E
S
R
E
Q
I
E
D
A
I
Q
G
A
D
M
V
F
V
T
S
G
M
G
G
G
T
G
T
G
A
A
P
V
V
A
K
I
A
K
E
M
G
A
L
T
V
G
V
V
T
R
P
F
S
F
E
G
R
K
R
Q
T
Q
A
A
A
G
V
E
A
M
K
A
A
V
D
T
L
I
V
I
P
N
D
R
L
L
D
I
V
D
K
S
T
P
M
M
E
A
F
K
E
A
D
N
V
L
R
Q
G
V
Q
G
I
S
D
L
I
A
V
S
G
E
V
N
L
--
D
--
F
A
D
V
K
T
I
M
S
N
Q
G
S
A
L
M
G
I
G
V
S
S
G
E
N
R
A
V
E
A
A
K
K
A
I
S
S
P
L
L
E
-
T
S
I
V
G
A
Q
G
V
L
M
N
I
T
G
G
E
S
L
S
L
F
E
A
Q
E
A
A
D
I
V
Q
D
A
A
D
E
D
V
N
M
I
F
G
T
V
I
N
P
E
L
-
Q
D
E
I
V
V
T
V
I
A
T
G
---------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
85.69
63%
-109
- C3 -
-
5MN6
1
FTSZ_STAAU
A:
[18-303]
--------------------------------
R
M
I
D
H
G
M
N
N
V
E
F
I
A
I
N
T
D
G
Q
A
L
N
L
S
K
A
E
S
K
I
Q
I
G
E
K
L
T
R
G
L
G
A
G
A
N
P
E
I
G
K
K
A
A
E
E
S
R
E
Q
I
E
D
A
I
Q
G
A
D
M
V
F
V
T
S
G
M
G
G
G
T
G
T
G
A
A
P
V
V
A
K
I
A
K
E
M
G
A
L
T
V
G
V
V
T
R
P
F
S
A
E
G
R
K
R
Q
T
Q
A
A
A
G
V
E
A
M
K
A
A
V
D
T
L
I
V
I
P
N
D
R
L
L
D
I
V
D
K
S
T
P
M
M
E
A
F
K
E
A
D
N
V
L
R
Q
G
V
Q
G
I
S
D
L
I
-------
L
--
D
--
F
A
D
V
K
T
I
M
S
N
Q
G
S
A
L
M
G
I
G
V
S
S
G
E
N
R
A
V
E
A
A
K
K
A
I
S
S
P
L
L
E
-
T
S
I
V
G
A
Q
G
V
L
M
N
I
T
G
G
E
S
L
S
L
F
E
A
Q
E
A
A
D
I
V
Q
D
A
A
D
E
D
V
N
M
I
F
G
T
V
I
N
P
E
L
-
Q
D
E
I
V
V
T
V
I
A
T
G
---------------------------------------------------------------------------------------------------------
27
PsiBlast_CBE
85.67
64%
-103
- C3 -
-
3WGN
1
FTSZ_STAAM
B:
[31-316]
--------------------------------
R
M
I
D
H
G
M
N
N
V
E
F
I
A
I
N
T
D
G
Q
A
L
N
L
S
K
A
E
S
K
I
Q
I
G
E
K
L
T
R
G
L
G
A
G
A
N
P
E
I
G
K
K
A
A
E
E
S
R
E
Q
I
E
D
A
I
Q
G
A
D
M
V
F
V
T
S
G
M
G
G
G
T
G
T
G
A
A
P
V
V
A
K
I
A
K
E
M
G
A
L
T
V
G
V
V
T
R
P
F
S
F
E
G
R
K
R
Q
T
Q
A
A
A
G
V
E
A
M
K
A
A
V
D
T
L
I
V
I
P
N
D
R
L
L
D
I
V
D
K
S
T
P
M
M
E
A
F
K
E
A
D
N
V
L
R
Q
G
V
Q
G
I
S
D
L
I
A
V
S
G
E
V
N
L
--
D
--
F
A
D
V
K
T
I
M
S
N
Q
G
S
A
L
M
G
I
G
V
S
S
G
E
N
R
A
V
E
A
A
K
K
A
I
S
S
P
L
L
E
-
T
S
I
V
G
A
Q
G
V
L
M
N
I
T
G
G
E
S
L
S
L
F
E
A
Q
E
A
A
D
I
V
Q
D
A
A
D
E
D
V
N
M
I
F
G
T
V
I
N
P
E
L
-
Q
D
E
I
V
V
T
V
I
A
T
G
---------------------------------------------------------------------------------------------------------
38
PsiBlast_CBE
85.62
63%
-107
- C3 -
-
3WGK
1
FTSZ_STAAM
A:
[31-314]
--------------------------------
R
M
I
D
H
G
M
N
N
V
E
F
I
A
I
N
T
D
G
Q
A
L
N
L
S
K
A
E
S
K
I
Q
I
G
E
K
L
T
R
G
L
G
A
G
A
N
P
E
I
G
K
K
A
A
E
E
S
R
E
Q
I
E
D
A
I
Q
G
A
D
M
V
F
V
T
S
G
M
G
G
G
T
G
T
G
A
A
P
V
V
A
K
I
A
K
E
M
G
A
L
T
V
G
V
V
T
R
P
F
S
F
E
G
R
K
R
Q
T
Q
A
A
A
G
V
E
A
M
K
A
A
V
D
T
L
I
V
I
P
N
D
R
L
L
D
I
V
D
K
S
T
P
M
M
E
A
F
K
E
A
D
N
V
L
R
Q
G
V
Q
G
I
S
D
L
I
A
V
G
A
--
G
L
--
D
--
F
A
D
V
K
T
I
M
S
N
Q
G
S
A
L
M
G
I
G
V
S
S
G
E
N
R
A
V
E
A
A
K
K
A
I
S
S
P
L
L
E
-
T
S
I
V
G
A
Q
G
V
L
M
N
I
T
G
G
E
S
L
S
L
F
E
A
Q
E
A
A
D
I
V
Q
D
A
A
D
E
D
V
N
M
I
F
G
T
V
I
N
P
E
L
-
Q
D
E
I
V
V
T
V
I
A
T
G
---------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
85.57
64%
-100
- C3 -
-
3WGN
1
FTSZ_STAAM
A:
[31-316]
--------------------------------
R
M
I
D
H
G
M
N
N
V
E
F
I
A
I
N
T
D
G
Q
A
L
N
L
S
K
A
E
S
K
I
Q
I
G
E
K
L
T
R
G
L
G
A
G
A
N
P
E
I
G
K
K
A
A
E
E
S
R
E
Q
I
E
D
A
I
Q
G
A
D
M
V
F
V
T
S
G
M
G
G
G
T
G
T
G
A
A
P
V
V
A
K
I
A
K
E
M
G
A
L
T
V
G
V
V
T
R
P
F
S
F
E
G
R
K
R
Q
T
Q
A
A
A
G
V
E
A
M
K
A
A
V
D
T
L
I
V
I
P
N
D
R
L
L
D
I
V
D
K
S
T
P
M
M
E
A
F
K
E
A
D
N
V
L
R
Q
G
V
Q
G
I
S
D
L
I
A
V
S
G
E
V
N
L
--
D
--
F
A
D
V
K
T
I
M
S
N
Q
G
S
A
L
M
G
I
G
V
S
S
G
E
N
R
A
V
E
A
A
K
K
A
I
S
S
P
L
L
E
-
T
S
I
V
G
A
Q
G
V
L
M
N
I
T
G
G
E
S
L
S
L
F
E
A
Q
E
A
A
D
I
V
Q
D
A
A
D
E
D
V
N
M
I
F
G
T
V
I
N
P
E
L
-
Q
D
E
I
V
V
T
V
I
A
T
G
---------------------------------------------------------------------------------------------------------
51
PsiBlast_CBE
85.39
56%
-108
- C3 -
-
2Q1X
1
FTSZ_MYCTU
A:
[22-311]
----------------------------
N
A
V
N
R
M
I
E
Q
G
L
K
G
V
E
F
I
A
I
N
T
D
A
Q
A
L
L
M
S
D
A
D
V
K
L
D
V
G
R
D
S
-------
A
D
P
E
V
G
R
K
A
A
E
D
A
K
D
E
I
E
E
L
L
R
G
A
D
M
V
F
V
T
A
G
E
G
G
G
T
G
T
G
G
A
P
V
V
A
S
I
A
R
K
L
G
A
L
T
V
G
V
V
T
R
P
F
S
F
E
G
K
R
R
S
N
Q
A
E
N
G
I
A
A
L
R
E
S
C
D
T
L
I
V
I
P
N
D
R
L
L
Q
M
G
D
A
A
V
S
L
M
D
A
F
R
S
A
D
E
V
L
L
N
G
V
Q
G
I
T
D
L
I
T
T
P
G
L
I
N
V
--
D
--
F
A
D
V
K
G
I
M
S
G
A
G
T
A
L
M
G
I
G
S
A
R
G
E
G
R
S
L
K
A
A
E
I
A
I
N
S
P
L
L
E
-
A
S
M
E
G
A
Q
G
V
L
M
S
I
A
G
G
S
D
L
G
L
F
E
I
N
E
A
A
S
L
V
Q
D
A
A
H
P
D
A
N
I
I
F
G
T
V
I
D
D
S
L
-
G
D
E
V
R
V
T
V
I
A
A
G
---------------------------------------------------------------------------------------------------------
40
PsiBlast_CBE
85.13
56%
-115
- C3 -
-
4KWE
1
FTSZ_MYCTU
B:
[25-314]
----------------------------
N
A
V
N
R
M
I
E
Q
G
L
K
G
V
E
F
I
A
I
N
T
D
A
Q
A
L
L
M
S
D
A
D
V
K
L
D
V
G
----------
A
D
P
E
V
G
R
K
A
A
E
D
A
K
D
E
I
E
E
L
L
R
G
A
D
M
V
F
V
T
A
G
E
G
G
G
T
G
T
G
G
A
P
V
V
A
S
I
A
R
K
L
G
A
L
T
V
G
V
V
T
R
P
F
S
F
E
G
K
R
R
S
N
Q
A
E
N
G
I
A
A
L
R
E
S
C
D
T
L
I
V
I
P
N
D
R
L
L
Q
M
G
D
A
A
V
S
L
M
D
A
F
R
S
A
D
E
V
L
L
N
G
V
Q
G
I
T
D
L
I
T
T
P
G
L
I
N
V
--
D
--
F
A
D
V
K
G
I
M
S
G
A
G
T
A
L
M
G
I
G
S
A
R
G
E
G
R
S
L
K
A
A
E
I
A
I
N
S
P
L
L
E
-
A
S
M
E
G
A
Q
G
V
L
M
S
I
A
G
G
S
D
L
G
L
F
E
I
N
E
A
A
S
L
V
Q
D
A
A
H
P
D
A
N
I
I
F
G
T
V
I
D
D
S
L
-
G
D
E
V
R
V
T
V
I
A
A
G
---------------------------------------------------------------------------------------------------------
39
PsiBlast_CBE
85.06
56%
-115
- C3 -
-
4KWE
1
FTSZ_MYCTU
C:
[25-314]
----------------------------
N
A
V
N
R
M
I
E
Q
G
L
K
G
V
E
F
I
A
I
N
T
D
A
Q
A
L
L
M
S
D
A
D
V
K
L
D
V
G
----------
A
D
P
E
V
G
R
K
A
A
E
D
A
K
D
E
I
E
E
L
L
R
G
A
D
M
V
F
V
T
A
G
E
G
G
G
T
G
T
G
G
A
P
V
V
A
S
I
A
R
K
L
G
A
L
T
V
G
V
V
T
R
P
F
S
F
E
G
K
R
R
S
N
Q
A
E
N
G
I
A
A
L
R
E
S
C
D
T
L
I
V
I
P
N
D
R
L
L
Q
M
G
D
A
A
V
S
L
M
D
A
F
R
S
A
D
E
V
L
L
N
G
V
Q
G
I
T
D
L
I
T
T
P
G
L
I
N
V
--
D
--
F
A
D
V
K
G
I
M
S
G
A
G
T
A
L
M
G
I
G
S
A
R
G
E
G
R
S
L
K
A
A
E
I
A
I
N
S
P
L
L
E
-
A
S
M
E
G
A
Q
G
V
L
M
S
I
A
G
G
S
D
L
G
L
F
E
I
N
E
A
A
S
L
V
Q
D
A
A
H
P
D
A
N
I
I
F
G
T
V
I
D
D
S
L
-
G
D
E
V
R
V
T
V
I
A
A
G
---------------------------------------------------------------------------------------------------------
36
PsiBlast_CBE
84.79
63%
-101
- C3 -
-
3WGL
1
FTSZ_STAAM
A:
[31-314]
--------------------------------
R
M
I
D
H
G
M
N
N
V
E
F
I
A
I
N
T
D
G
Q
A
L
N
L
S
K
A
E
S
K
I
Q
I
G
E
K
L
T
R
G
L
G
A
G
A
N
P
E
I
G
K
K
A
A
E
E
S
R
E
Q
I
E
D
A
I
Q
G
A
D
M
V
F
V
T
S
G
M
G
G
G
T
G
T
G
A
A
P
V
V
A
K
I
A
K
E
M
G
A
L
T
V
G
V
V
T
R
P
F
S
F
E
G
R
K
R
Q
T
Q
A
A
A
G
V
E
A
M
K
A
A
V
D
T
L
I
V
I
P
N
D
R
L
L
D
I
V
D
K
S
T
P
M
M
E
A
F
K
E
A
D
N
V
L
R
Q
G
V
Q
G
I
S
D
L
I
A
V
G
A
--
N
L
--
D
--
F
A
D
V
K
T
I
M
S
N
Q
G
S
A
L
M
G
I
G
V
S
S
G
E
N
R
A
V
E
A
A
K
K
A
I
S
S
P
L
L
E
-
T
S
I
V
G
A
Q
G
V
L
M
N
I
T
G
G
E
S
L
S
L
F
E
A
Q
E
A
A
D
I
V
Q
D
A
A
D
E
D
V
N
M
I
F
G
T
V
I
N
P
E
L
-
Q
D
E
I
V
V
T
V
I
A
T
G
---------------------------------------------------------------------------------------------------------
32
PsiBlast_CBE
84.55
63%
-99
- C3 -
-
5MN6
1
FTSZ_STAAU
B:
[18-303]
--------------------------------
R
M
I
D
H
G
M
N
N
V
E
F
I
A
I
N
T
D
G
Q
A
L
N
L
S
K
A
E
S
K
I
Q
I
G
E
K
L
T
R
G
L
G
A
G
A
N
P
E
I
G
K
K
A
A
E
E
S
R
E
Q
I
E
D
A
I
Q
G
A
D
M
V
F
V
T
S
G
M
G
G
G
T
G
T
G
A
A
P
V
V
A
K
I
A
K
E
M
G
A
L
T
V
G
V
V
T
R
P
F
S
A
E
G
R
K
R
Q
T
Q
A
A
A
G
V
E
A
M
K
A
A
V
D
T
L
I
V
I
P
N
D
R
L
L
D
I
V
D
K
S
T
P
M
M
E
A
F
K
E
A
D
N
V
L
R
Q
G
V
Q
G
I
S
D
L
I
A
V
S
G
E
V
N
L
--
D
--
F
A
D
V
K
T
I
M
S
N
Q
G
S
A
L
M
G
I
G
V
S
S
G
E
N
R
A
V
E
A
A
K
K
A
I
S
S
P
L
L
E
-
T
S
I
V
G
A
Q
G
V
L
M
N
I
T
G
G
E
S
L
S
L
F
E
A
Q
E
A
A
D
I
V
Q
D
A
A
D
E
D
V
N
M
I
F
G
T
V
I
N
P
E
L
-
Q
D
E
I
V
V
T
V
I
A
T
G
---------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
84.46
63%
-107
- C3 -
-
5MN5
1
FTSZ_STAAU
A:
[18-303]
--------------------------------
R
M
I
D
H
G
M
N
N
V
E
F
I
A
I
N
T
D
G
Q
A
L
N
L
S
K
A
E
S
K
I
Q
I
G
-----------
N
P
E
I
G
K
K
A
A
E
E
S
R
E
Q
I
E
D
A
I
Q
G
A
D
M
V
F
V
T
S
G
M
G
G
G
T
G
T
G
A
A
P
V
V
A
K
I
A
K
E
M
G
A
L
T
V
G
V
V
T
R
P
F
S
F
E
G
R
K
R
Q
T
Q
A
A
A
G
V
E
A
M
K
A
A
V
D
T
L
I
V
I
P
N
D
R
L
L
D
I
V
D
K
S
T
P
M
M
E
A
F
K
E
A
D
N
V
L
R
Q
G
V
Q
G
I
S
D
L
I
A
V
S
G
E
V
N
L
--
D
--
F
A
D
V
K
T
I
M
S
N
Q
G
S
A
L
M
G
I
G
V
S
S
G
E
N
R
A
V
E
A
A
K
K
A
I
S
S
P
L
L
E
-
T
S
I
V
G
A
Q
G
V
L
M
N
I
T
G
G
E
S
L
S
L
F
E
A
Q
E
A
A
D
I
V
Q
D
A
A
D
E
D
V
N
M
I
F
G
T
V
I
N
P
E
L
-
Q
D
E
I
V
V
T
V
I
A
T
G
---------------------------------------------------------------------------------------------------------
42
PsiBlast_CBE
84.34
56%
-109
- C3 -
-
1RQ7
1
FTSZ_MYCTU
A:
[25-314]
----------------------------
N
A
V
N
R
M
I
E
Q
G
L
K
G
V
E
F
I
A
I
N
T
D
A
Q
A
L
L
M
S
D
A
D
V
K
L
D
V
G
R
D
S
T
-----
G
A
D
P
E
V
G
R
K
A
A
E
D
A
K
D
E
I
E
E
L
L
R
G
A
D
M
V
F
V
T
A
G
E
G
G
G
T
G
T
G
G
A
P
V
V
A
S
I
A
R
K
L
G
A
L
T
V
G
V
V
T
R
P
F
S
F
E
G
K
R
R
S
N
Q
A
E
N
G
I
A
A
L
R
E
S
C
D
T
L
I
V
I
P
N
D
R
L
L
Q
M
G
D
A
A
V
S
L
M
D
A
F
R
S
A
D
E
V
L
L
N
G
V
Q
G
I
T
D
L
I
T
T
P
G
L
I
N
V
--
D
--
F
A
D
V
K
G
I
M
S
G
A
G
T
A
L
M
G
I
G
S
A
R
G
E
G
R
S
L
K
A
A
E
I
A
I
N
S
P
L
L
E
-
A
S
M
E
G
A
Q
G
V
L
M
S
I
A
G
G
S
D
L
G
L
F
E
I
N
E
A
A
S
L
V
Q
D
A
A
H
P
D
A
N
I
I
F
G
T
V
I
D
D
S
L
-
G
D
E
V
R
V
T
V
I
A
A
G
---------------------------------------------------------------------------------------------------------
41
PsiBlast_CBE
83.95
56%
-111
- C3 -
-
4KWE
1
FTSZ_MYCTU
A:
[25-314]
----------------------------
N
A
V
N
R
M
I
E
Q
G
L
K
G
V
E
F
I
A
I
N
T
D
A
Q
A
L
L
M
S
D
A
D
V
K
L
D
V
G
R
D
S
T
R
G
L
G
A
G
A
D
P
E
V
G
R
K
A
A
E
D
A
K
D
E
I
E
E
L
L
R
G
A
D
M
V
F
V
T
A
G
E
G
G
G
T
G
T
G
G
A
P
V
V
A
S
I
A
R
K
L
G
A
L
T
V
G
V
V
T
R
P
F
S
F
E
G
K
R
R
S
N
Q
A
E
N
G
I
A
A
L
R
E
S
C
D
T
L
I
V
I
P
N
D
R
L
L
Q
M
G
D
A
A
V
S
L
M
D
A
F
R
S
A
D
E
V
L
L
N
G
V
Q
G
I
T
D
L
I
T
T
P
G
L
I
N
V
--
D
--
F
A
D
V
K
G
I
M
S
G
A
G
T
A
L
M
G
I
G
S
A
R
G
E
G
R
S
L
K
A
A
E
I
A
I
N
S
P
L
L
E
-
A
S
M
E
G
A
Q
G
V
L
M
S
I
A
G
G
S
D
L
G
L
F
E
I
N
E
A
A
S
L
V
Q
D
A
A
H
P
D
A
N
I
I
F
G
T
V
I
D
D
S
L
-
G
D
E
V
R
V
T
V
I
A
A
G
---------------------------------------------------------------------------------------------------------
45
PsiBlast_CBE
83.68
56%
-101
- C3 -
-
1RLU
2
FTSZ_MYCTU
A:
[25-314]
----------------------------
N
A
V
N
R
M
I
E
Q
G
L
K
G
V
E
F
I
A
I
N
T
D
A
Q
A
L
L
M
S
D
A
D
V
K
L
D
V
G
R
D
S
T
R
G
L
G
A
G
A
D
P
E
V
G
R
K
A
A
E
D
A
K
D
E
I
E
E
L
L
R
G
A
D
M
V
F
V
T
A
G
E
G
G
G
T
G
T
G
G
A
P
V
V
A
S
I
A
R
K
L
G
A
L
T
V
G
V
V
T
R
P
F
S
F
E
G
K
R
R
S
N
Q
A
E
N
G
I
A
A
L
R
E
S
C
D
T
L
I
V
I
P
N
D
R
L
L
Q
M
G
D
A
A
V
S
L
M
D
A
F
R
S
A
D
E
V
L
L
N
G
V
Q
G
I
T
D
L
I
T
T
P
G
L
I
N
V
--
D
--
F
A
D
V
K
G
I
M
S
G
A
G
T
A
L
M
G
I
G
S
A
R
G
E
G
R
S
L
K
A
A
E
I
A
I
N
S
P
L
L
E
-
A
S
M
E
G
A
Q
G
V
L
M
S
I
A
G
G
S
D
L
G
L
F
E
I
N
E
A
A
S
L
V
Q
D
A
A
H
P
D
A
N
I
I
F
G
T
V
I
D
D
S
L
-
G
D
E
V
R
V
T
V
I
A
A
G
---------------------------------------------------------------------------------------------------------
43
PsiBlast_CBE
83.60
56%
-107
- C3 -
-
1RQ2
1
FTSZ_MYCTU
A:
[25-314]
----------------------------
N
A
V
N
R
M
I
E
Q
G
L
K
G
V
E
F
I
A
I
N
T
D
A
Q
A
L
L
M
S
D
A
D
V
K
L
D
V
G
R
D
S
T
-----
G
A
D
P
E
V
G
R
K
A
A
E
D
A
K
D
E
I
E
E
L
L
R
G
A
D
M
V
F
V
T
A
G
E
G
G
G
T
G
T
G
G
A
P
V
V
A
S
I
A
R
K
L
G
A
L
T
V
G
V
V
T
R
P
F
S
F
E
G
K
R
R
S
N
Q
A
E
N
G
I
A
A
L
R
E
S
C
D
T
L
I
V
I
P
N
D
R
L
L
Q
M
G
D
A
A
V
S
L
M
D
A
F
R
S
A
D
E
V
L
L
N
G
V
Q
G
I
T
D
L
I
T
T
P
G
L
I
N
V
--
D
--
F
A
D
V
K
G
I
M
S
G
A
G
T
A
L
M
G
I
G
S
A
R
G
E
G
R
S
L
K
A
A
E
I
A
I
N
S
P
L
L
E
-
A
S
M
E
G
A
Q
G
V
L
M
S
I
A
G
G
S
D
L
G
L
F
E
I
N
E
A
A
S
L
V
Q
D
A
A
H
P
D
A
N
I
I
F
G
T
V
I
D
D
S
L
-
G
D
E
V
R
V
T
V
I
A
A
G
---------------------------------------------------------------------------------------------------------
50
PsiBlast_CBE
83.50
56%
-104
- C3 -
-
2Q1Y
1
FTSZ_MYCTU
A:
[22-311]
----------------------------
N
A
V
N
R
M
I
E
Q
G
L
K
G
V
E
F
I
A
I
N
T
D
A
Q
A
L
L
M
S
D
A
D
V
K
L
D
V
G
R
D
S
T
R
G
L
G
A
G
A
D
P
E
V
G
R
K
A
A
E
D
A
K
D
E
I
E
E
L
L
R
G
A
D
M
V
F
V
T
A
G
E
G
G
G
T
G
T
G
G
A
P
V
V
A
S
I
A
R
K
L
G
A
L
T
V
G
V
V
T
R
P
F
S
F
E
G
K
R
R
S
N
Q
A
E
N
G
I
A
A
L
R
E
S
C
D
T
L
I
V
I
P
N
D
R
L
L
Q
M
G
D
A
A
V
S
L
M
D
A
F
R
S
A
D
E
V
L
L
N
G
V
Q
G
I
T
D
L
I
T
T
P
G
L
I
N
V
--
D
--
F
A
D
V
K
G
I
M
S
G
A
G
T
A
L
M
G
I
G
S
A
R
G
E
G
R
S
L
K
A
A
E
I
A
I
N
S
P
L
L
E
-
A
S
M
E
G
A
Q
G
V
L
M
S
I
A
G
G
S
D
L
G
L
F
E
I
N
E
A
A
S
L
V
Q
D
A
A
H
P
D
A
N
I
I
F
G
T
V
I
D
D
S
L
-
G
D
E
V
R
V
T
V
I
A
A
G
---------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
83.15
54%
-109
- C3 -
-
2VXY
1
FTSZ_BACSU
A:
[29-316]
--------------------------------
R
M
I
E
N
E
V
Q
G
V
E
Y
I
A
V
N
T
D
A
Q
A
L
N
L
S
K
A
E
V
K
M
Q
I
G
A
K
L
T
R
G
L
G
A
G
A
N
P
E
V
G
K
K
A
A
E
E
S
K
E
Q
I
E
E
A
L
K
G
A
D
M
V
F
V
T
A
G
M
G
G
G
T
G
T
G
A
A
P
V
I
A
Q
I
A
K
D
L
G
A
L
T
V
G
V
V
T
R
P
F
T
F
E
G
R
K
R
Q
L
Q
A
A
G
G
I
S
A
M
K
E
A
V
D
T
L
I
V
I
P
N
D
R
I
L
E
I
V
D
K
N
T
P
M
L
E
A
F
R
E
A
D
N
V
L
R
Q
G
V
Q
G
I
S
D
L
I
A
T
P
G
L
I
N
L
--
D
--
F
A
D
V
K
T
I
M
S
N
K
G
S
A
L
M
G
I
G
I
A
T
G
E
N
R
A
A
E
A
A
K
K
A
I
S
S
P
L
L
E
-
A
A
I
D
G
A
Q
G
V
L
M
N
I
T
G
G
T
N
L
S
L
Y
E
V
Q
E
A
A
D
I
V
A
S
A
S
D
Q
D
V
N
M
I
F
G
S
V
I
N
E
N
L
-
K
D
E
I
V
V
T
V
I
A
T
G
F
I
-------------------------------------------------------------------------------------------------------
53
PsiBlast_CBE
82.27
55%
-84
- C3 -
-
1OFU
1
FTSZ_PSEAE
B:
[25-316]
----------------------------
N
A
V
N
H
M
A
K
N
N
V
E
G
V
E
F
I
C
A
N
T
D
A
Q
A
L
K
N
I
A
A
R
T
V
L
Q
L
G
P
G
V
T
K
G
L
G
A
G
A
N
P
E
V
G
R
Q
A
A
L
E
D
R
E
R
I
S
E
V
L
E
G
A
D
M
V
F
I
T
T
G
M
G
G
G
T
G
T
G
A
A
P
I
I
A
E
V
A
K
E
M
G
I
L
T
V
A
V
V
T
R
P
F
P
F
E
G
R
K
R
M
Q
I
A
D
E
G
I
R
A
L
A
E
S
V
D
S
L
I
T
I
P
N
E
K
L
L
T
I
L
G
K
D
A
S
L
L
A
A
F
A
K
A
D
D
V
L
A
G
A
V
R
G
I
S
D
I
I
K
R
P
G
M
I
N
V
--
D
--
F
A
D
V
K
T
V
M
S
E
M
G
M
A
M
M
G
T
G
C
A
S
G
P
N
R
A
R
E
A
T
E
A
A
I
R
N
P
L
L
E
D
V
N
L
Q
G
A
R
G
I
L
V
N
I
T
A
G
P
D
L
S
L
G
E
Y
S
D
V
G
N
I
I
E
Q
F
A
S
E
H
A
T
V
K
V
G
T
V
I
D
A
D
M
-
R
D
E
L
H
V
T
V
V
A
T
G
-
L
-------------------------------------------------------------------------------------------------------
54
PsiBlast_CBE
81.23
55%
-85
- C3 -
-
1OFU
1
FTSZ_PSEAE
A:
[25-316]
----------------------------
N
A
V
N
H
M
A
K
N
N
V
E
G
V
E
F
I
C
A
N
T
D
A
Q
A
L
K
N
I
A
A
R
T
V
L
Q
L
G
P
G
V
T
K
G
L
G
A
G
A
N
P
E
V
G
R
Q
A
A
L
E
D
R
E
R
I
S
E
V
L
E
G
A
D
M
V
F
I
T
T
G
M
G
G
G
T
G
T
G
A
A
P
I
I
A
E
V
A
K
E
M
G
I
L
T
V
A
V
V
T
R
P
F
P
F
E
G
R
K
R
M
Q
I
A
D
E
G
I
R
A
L
A
E
S
V
D
S
L
I
T
I
P
N
E
K
L
L
T
I
L
G
K
D
A
S
L
L
A
A
F
A
K
A
D
D
V
L
A
G
A
V
R
G
I
S
D
I
I
K
R
P
G
M
I
N
V
--
D
--
F
A
D
V
K
T
V
M
S
E
M
G
M
A
M
M
G
T
G
C
A
S
G
P
N
R
A
R
E
A
T
E
A
A
I
R
N
P
L
L
E
D
V
N
L
Q
G
A
R
G
I
L
V
N
I
T
A
G
P
D
L
S
L
G
E
Y
S
D
V
G
N
I
I
E
Q
F
A
S
E
H
A
T
V
K
V
G
T
V
I
D
A
D
M
-
R
D
E
L
H
V
T
V
V
A
T
G
-
L
-------------------------------------------------------------------------------------------------------
52
PsiBlast_CBE
79.31
51%
-82
- C3 -
-
2VAW
1
FTSZ_PSEAE
A:
[25-316]
----------------------------
N
A
V
N
H
M
A
K
N
N
V
E
G
V
E
F
I
C
A
N
T
D
A
Q
A
L
K
N
I
A
A
R
T
V
L
Q
L
G
P
G
V
T
K
G
L
G
A
G
A
N
P
E
V
G
R
Q
A
A
L
E
D
R
E
R
I
S
E
V
L
E
G
A
D
M
V
F
I
T
T
G
M
G
G
G
T
G
T
G
A
A
P
I
I
A
E
V
A
K
E
M
G
I
L
T
V
A
V
V
T
R
P
F
P
F
E
G
R
K
R
M
Q
I
A
D
E
G
I
R
A
L
A
E
S
V
D
S
L
I
T
I
P
N
E
K
L
L
T
I
L
G
K
D
A
S
L
L
A
A
F
A
K
A
D
D
V
L
A
G
A
V
R
G
I
S
D
I
I
K
R
P
G
M
I
N
V
--
D
--
F
A
D
V
K
T
V
M
S
E
M
G
M
A
M
M
G
T
G
C
A
S
G
P
N
R
A
R
E
A
T
E
A
A
I
R
N
P
L
L
E
D
V
N
L
Q
G
A
R
G
I
L
V
N
I
T
A
G
P
D
L
S
L
G
E
Y
S
D
V
G
N
I
I
E
Q
F
A
S
E
H
A
T
V
K
V
G
T
V
I
D
A
D
M
-
R
D
E
L
H
V
T
V
V
A
T
G
-
L
-------------------------------------------------------------------------------------------------------
55
PsiBlast_CBE
74.05
47%
-47
- C3 -
-
1W5F
1
FTSZ_THEMA
B:
[22-336]
---------------
L
K
I
K
V
I
G
V
G
G
A
G
N
N
A
I
N
R
M
I
E
I
G
I
H
G
V
E
F
V
A
V
N
T
D
L
Q
V
L
E
A
S
N
A
D
V
K
I
Q
I
G
E
N
I
T
R
G
L
G
A
G
G
R
P
E
I
G
E
Q
A
A
L
E
S
E
E
K
I
R
E
V
L
Q
D
T
H
M
V
F
I
T
A
G
F
G
G
G
T
G
T
G
A
S
P
V
I
A
K
I
A
K
E
M
G
I
L
T
V
A
I
V
T
T
P
F
Y
F
E
G
P
E
R
L
K
K
A
I
E
G
L
K
K
L
R
K
H
V
D
T
L
I
K
I
S
N
N
K
L
M
E
E
L
P
R
D
V
K
I
K
D
A
F
L
K
A
D
E
T
L
H
Q
G
V
K
G
I
S
E
L
I
T
K
R
G
Y
I
R
L
--
T
SR
F
A
R
I
E
S
V
M
K
D
A
G
A
A
I
L
G
I
G
V
G
K
G
E
H
R
A
R
E
A
A
K
K
A
M
E
S
K
L
I
E
-
H
P
V
E
N
A
S
S
I
V
F
N
I
T
A
P
S
N
I
R
M
E
E
V
H
E
A
A
M
I
I
R
Q
N
S
S
E
D
A
D
V
K
F
G
L
I
F
D
D
E
V
P
D
D
E
I
R
V
I
F
I
A
T
---
R
F
P
D
E
D
K
I
L
F
---------------------------------------------------------------------------------------------
82
HHSearch
74.04
48%
-48
- C3 -
-
1W5F
1
FTSZ_THEMA
A:
[22-336]
---------------
L
K
I
K
V
I
G
V
G
G
A
G
N
N
A
I
N
R
M
I
E
I
G
I
H
G
V
E
F
V
A
V
N
T
D
L
Q
V
L
E
A
S
N
A
D
V
K
I
Q
I
G
E
N
I
T
R
G
L
G
A
G
G
R
P
E
I
G
E
Q
A
A
L
E
S
E
E
K
I
R
E
V
L
Q
D
T
H
M
V
F
I
T
A
G
F
G
G
G
T
G
T
G
A
S
P
V
I
A
K
I
A
K
E
M
G
I
L
T
V
A
I
V
T
T
P
F
Y
F
E
G
P
E
R
L
K
K
A
I
E
G
L
K
K
L
R
K
H
V
D
T
L
I
K
I
S
N
N
K
L
M
E
E
L
P
R
D
V
K
I
K
D
A
F
L
K
A
D
E
T
L
H
Q
G
V
K
G
I
S
E
L
I
T
K
R
G
Y
I
R
L
T
S
R
--
F
A
R
I
E
S
V
M
K
D
A
G
A
A
I
L
G
I
G
V
G
K
G
E
H
R
A
R
E
A
A
K
K
A
M
E
S
K
L
I
E
-
H
P
V
E
N
A
S
S
I
V
F
N
I
T
A
P
S
N
I
R
M
E
E
V
H
E
A
A
M
I
I
R
Q
N
S
S
E
D
A
D
V
K
F
G
L
I
F
D
D
E
V
P
D
D
E
I
R
V
I
F
I
A
T
R
-
F
P
D
E
D
K
I
L
F
-----------------------------------------------------------------------------------------------
56
PsiBlast_CBE
72.91
47%
-47
- C3 -
-
1W5F
1
FTSZ_THEMA
A:
[22-336]
---------------
L
K
I
K
V
I
G
V
G
G
A
G
N
N
A
I
N
R
M
I
E
I
G
I
H
G
V
E
F
V
A
V
N
T
D
L
Q
V
L
E
A
S
N
A
D
V
K
I
Q
I
G
E
N
I
T
R
G
L
G
A
G
G
R
P
E
I
G
E
Q
A
A
L
E
S
E
E
K
I
R
E
V
L
Q
D
T
H
M
V
F
I
T
A
G
F
G
G
G
T
G
T
G
A
S
P
V
I
A
K
I
A
K
E
M
G
I
L
T
V
A
I
V
T
T
P
F
Y
F
E
G
P
E
R
L
K
K
A
I
E
G
L
K
K
L
R
K
H
V
D
T
L
I
K
I
S
N
N
K
L
M
E
E
L
P
R
D
V
K
I
K
D
A
F
L
K
A
D
E
T
L
H
Q
G
V
K
G
I
S
E
L
I
T
K
R
G
Y
I
R
L
--
T
S
R
F
A
R
I
E
S
V
M
K
D
A
G
A
A
I
L
G
I
G
V
G
K
G
E
H
R
A
R
E
A
A
K
K
A
M
E
S
K
L
I
E
-
H
P
V
E
N
A
S
S
I
V
F
N
I
T
A
P
S
N
I
R
M
E
E
V
H
E
A
A
M
I
I
R
Q
N
S
S
E
D
A
D
V
K
F
G
L
I
F
D
D
E
V
P
D
D
E
I
R
V
I
F
I
A
T
---
R
F
P
D
E
D
K
I
L
F
---------------------------------------------------------------------------------------------
97
Fugue
54.35
50%
-1
- C3 -
-
1FSZ
1
?
?:
[23-231]
S
P
E
D
K
E
L
L
E
Y
L
Q
Q
T
K
A
K
I
T
V
V
G
C
G
G
A
G
N
N
T
I
T
R
L
K
M
E
G
I
E
G
A
K
T
V
A
I
N
T
D
A
Q
Q
L
I
R
T
K
A
D
K
K
I
L
I
G
K
K
L
T
R
G
L
G
A
G
G
N
P
K
I
G
E
E
A
A
K
E
S
A
E
E
I
K
A
A
I
Q
D
S
D
M
V
F
I
T
C
G
L
G
G
G
T
G
T
G
S
A
P
V
V
A
E
I
S
K
K
I
G
A
L
T
V
A
V
V
T
L
P
F
V
M
E
G
K
V
R
M
K
N
A
M
E
G
L
E
R
L
K
Q
H
T
D
T
L
V
V
I
P
N
E
K
L
F
E
I
V
-
P
N
M
P
L
K
L
A
F
K
V
A
D
E
V
L
I
N
A
V
K
G
L
V
E
L
I
T
K
D
G
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------