@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : spr1511: (2018-01-13 )
MAREGFFTGLDIGTSSVKVLVAEQRNGELNVIGVSNAKSKGVKDGIIVDIDAAATAIKSAISQAEEKAGISIKSVNVGLPGNLLQVEPTQGMIPVTSDTKEITDQDVENVVKSALTKSMTPDREVITFIPEEFIVDGFQGIRDPRGMMGVRLEMRGLLYTGPRTILHNLRKTVERAGVQVENVIISPLAMVQSVLNEGEREFGATVIDMGAGQTTVATIRNQELQFTHILQEGGDYVTKDISKVLKTSRKLAEGLKLNYGEAYPPLASKETFQVEVIGEVEAVEVTEAYLSEIISARIKHILEQIKQELDRRRLLDLPGGIVLIGGNAILPGMVELAQEVFGVRVKLYVPNQVGIRNPAFAHVISLSEFAGQLTEVNLLAQGAIKGENDLSHQPISFGGMLQKTAQFVQSTPVQPAPAPEVEPVAPTEPMADFQQASQNKPKLADRFRGLIGSMFDE
Atome Classification :
(20 SA)
.........10........20........30....--..--..40........50........60........70.-..-.....80-.........90.........100.......110.......120.......130.......140.......150-........160----...---....170.......180.......190...-..--.------.200.....---..210.......220........230-..-.....240...------------------..-..250.......260.....--.-.270...-....280....-...290.......300.....---..----310..-------..-.-..320.......330.......340--......-------.350.-------------....-----..360---------------.-.......370.......380........390.......400.......410.......420----........430......-.440.......450.....-------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MAREG
F
F
T
G
L
DIGTS
S
V
K
V
L
V
A
EQRNG
E
L
N
V
I
GVS--NA--KSKGVKD
G
I
I
V
DI
D
A
A
A
T
A
I
K
S
A
I
S
Q
A
E
E
KAG
I
S
I
-
K
S
-
V
NVGLP--G
N
L
L
Q
VEPTQ-GMIPVTSD
T
K
E
I
T
D
Q
D
V
E
N
V
V
K
S
A
L
T
KSMTPD
R
E
V
I
T
FI
P
E
E
F
I
V
D
G
F
Q
GIRDPRG
M
M
G
V
-
R
-
L
E
MR
G
L
L
YT
G
P
----
R
T
I
---
L
H
N
L
R
K
T
V
E
R
AG
V
Q
V
E
N
V
I
I
S
P
L
A
M
V
Q
S
V
L
-NE--
G
------
E
R
E
FG
A
T
V
I
---DMGAG
Q
T
T
V
A
T
IRN-QE
L
Q
F
T
H
I
L
Q
E-GG-
D
Y
V
T
K
D
I
S
K
V
L
------------------
K
T
-
S
R
K
L
A
E
GLKLNYGEAYPPLA--S-K
E
T
F
Q
V
E
-
V
I
GEV
E
A
V
E
V
T
-
E
A
Y
L
S
E
I
I
S
A
R
I
K
H
I
L
E
Q
I
K
Q
---
E
L
----
D
R
R
R
L
-------LD-L-PG
G
I
V
L
IGGN
A
I
L
P
G
M
V
E
L
A
Q
E
V
FG--
V
R
V
K
L
Y
-------VPNQV-------------GIRN-----P
A
F
A
----------------
H
-
V
I
S
L
S
E
F
AG
Q
L
T
E
V
N
L
L
A
Q-GAIKGENDLSHQPIS
F
G
G
M
L
Q
K
T
A
Q
F
V
Q
STPVQPAPAPEV-----EPVAPTE
P
M
A
D
F
Q
Q
ASQ-NK
P
K
L
A
D
R
F
R
G
L
I
G
S
MFDE-------------------------------
28
HHSearch
89.63
33%
-5
* C1 *
-
3WT0
1
FTSA_STAAW
D:
[21-394]
---
E
H
Y
Y
V
S
I
D
I
G
S
S
S
V
K
T
I
V
G
E
K
F
H
N
G
I
N
V
I
G
T
G
--
Q
T
--
Y
T
S
G
I
K
N
G
L
I
D
D
F
D
I
A
R
Q
A
I
K
D
T
I
K
K
A
S
I
A
S
G
V
D
I
-
K
E
-
V
F
L
K
L
P
II
G
T
E
V
Y
D
E
S
N
E
---
I
D
F
Y
E
-
D
T
E
I
N
G
S
H
I
E
K
V
L
E
G
I
R
E
K
N
D
V
Q
E
T
E
V
I
N
V
F
P
I
R
F
I
V
D
K
E
N
E
V
S
D
P
K
E
L
I
A
R
H
S
-
L
K
V
E
A
G
V
I
A
I
Q
----
K
S
I
---
L
I
N
M
I
K
C
V
E
A
C
G
V
D
V
L
D
V
Y
S
D
A
Y
N
Y
G
S
I
L
T
-
A
T
---------
E
K
E
L
G
A
C
V
I
---
D
I
G
E
D
V
T
Q
V
A
F
Y
E
R
-
G
E
L
V
D
A
D
S
I
E
M
-
A
G
-
R
D
I
T
D
D
I
A
Q
G
L
------------------
N
T
-
S
Y
E
T
A
E
K
V
K
H
Q
Y
G
H
A
F
Y
D
S
A
--
S
D
Q
D
I
F
T
V
E
-
Q
V
D
S
D
E
T
V
Q
Y
T
-
Q
K
D
L
S
D
F
I
E
A
R
V
E
E
I
F
F
E
V
F
D
---
V
L
----
Q
D
L
G
L
-------
T
K
-
V
-
N
G
G
F
I
V
T
G
G
S
A
N
L
L
G
V
K
E
L
L
S
D
M
V
S
--
E
K
V
R
I
H
-------
T
P
S
Q
M
-------------
G
I
R
K
-----
P
E
F
S
----------------
S
-
A
I
S
T
I
S
S
S
I
A
F
D
E
L
L
----------------------------------------------------------------------------------------------------------------------
23
PsiBlast_CBE
88.65
34%
-15
- C1 -
-
3WT0
1
FTSA_STAAW
B:
[20-377]
--
E
E
H
Y
Y
V
S
I
D
I
G
S
S
S
V
K
T
I
V
G
E
K
F
H
N
G
I
N
V
I
G
T
G
--
Q
T
--
Y
T
S
G
I
K
N
G
L
I
D
D
F
D
I
A
R
Q
A
I
K
D
T
I
K
K
A
S
I
A
S
G
V
D
I
-
K
E
-
V
F
L
K
L
P
--
I
I
G
T
E
V
Y
D
E
S
-
N
E
I
D
F
Y
E
D
T
-
E
I
N
G
S
H
I
E
K
V
L
E
G
I
R
E
K
N
D
V
Q
E
T
E
V
I
N
V
F
P
I
R
F
I
V
D
K
E
N
E
V
S
D
P
K
E
L
I
A
R
-
H
S
L
K
V
E
A
G
V
I
A
I
Q
----
K
S
I
---
L
I
N
M
I
K
C
V
E
A
C
G
V
D
V
L
D
V
Y
-
S
D
A
Y
N
Y
G
S
I
L
-
T
A
--
T
------
E
K
E
L
G
A
C
V
I
---
D
I
G
E
D
V
T
Q
V
A
F
Y
E
R
-
G
E
L
V
D
A
D
S
I
E
M
-
A
G
-
R
D
I
T
D
D
I
A
Q
G
L
------------------
N
T
-
S
Y
E
T
A
E
K
V
K
H
Q
Y
G
H
A
F
Y
D
S
A
--
S
D
Q
D
I
F
T
V
E
-
Q
V
D
S
D
E
T
V
Q
Y
T
-
Q
K
D
L
S
D
F
I
E
A
R
V
E
E
I
F
F
E
V
F
D
---
V
L
----
Q
D
L
G
L
-------
T
K
-
V
-
N
G
G
F
I
V
T
G
G
S
A
N
L
L
G
V
K
E
L
L
S
D
M
V
S
--
E
K
V
R
I
H
-------
T
P
S
Q
M
-------------
G
I
R
K
-----
P
E
F
--------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
88.59
34%
-18
- C1 -
-
3WT0
1
FTSA_STAAW
A:
[20-377]
--
E
E
H
Y
Y
V
S
I
D
I
G
S
S
S
V
K
T
I
V
G
E
K
F
H
N
G
I
N
V
I
G
T
G
--
Q
T
--
Y
T
S
G
I
K
N
G
L
I
D
D
F
D
I
A
R
Q
A
I
K
D
T
I
K
K
A
S
I
A
S
G
V
D
I
-
K
E
-
V
F
L
K
L
P
--
I
I
G
T
E
V
Y
D
E
S
-
N
E
I
D
F
Y
E
D
T
-
E
I
N
G
S
H
I
E
K
V
L
E
G
I
R
E
K
N
D
V
Q
E
T
E
V
I
N
V
F
P
I
R
F
I
V
D
K
E
N
E
V
S
D
P
K
E
L
I
A
R
-
H
S
L
K
V
E
A
G
V
I
A
I
Q
----
K
S
I
---
L
I
N
M
I
K
C
V
E
A
C
G
V
D
V
L
D
V
Y
-
S
D
A
Y
N
Y
G
S
I
L
-
T
A
--
T
------
E
K
E
L
G
A
C
V
I
---
D
I
G
E
D
V
T
Q
V
A
F
Y
E
R
-
G
E
L
V
D
A
D
S
I
E
M
-
A
G
-
R
D
I
T
D
D
I
A
Q
G
L
------------------
N
T
-
S
Y
E
T
A
E
K
V
K
H
Q
Y
G
H
A
F
Y
D
S
A
--
S
D
Q
D
I
F
T
V
E
-
Q
V
D
S
D
E
T
V
Q
Y
T
-
Q
K
D
L
S
D
F
I
E
A
R
V
E
E
I
F
F
E
V
F
D
---
V
L
----
Q
D
L
G
L
-------
T
K
-
V
-
N
G
G
F
I
V
T
G
G
S
A
N
L
L
G
V
K
E
L
L
S
D
M
V
S
--
E
K
V
R
I
H
-------
T
P
S
Q
M
-------------
G
I
R
K
-----
P
E
F
--------------------------------------------------------------------------------------------------------------------------------------------------------
29
HHSearch
88.35
33%
-6
- C1 -
-
3WT0
1
FTSA_STAAW
C:
[22-394]
----
H
Y
Y
V
S
I
D
I
G
S
S
S
V
K
T
I
V
G
E
K
F
H
N
G
I
N
V
I
G
T
G
--
Q
T
--
Y
T
S
G
I
K
N
G
L
I
D
D
F
D
I
A
R
Q
A
I
K
D
T
I
K
K
A
S
I
A
S
G
V
D
I
-
K
E
-
V
F
L
K
L
P
II
G
T
E
V
Y
D
E
S
N
E
---
I
D
F
Y
E
-
D
T
E
I
N
G
S
H
I
E
K
V
L
E
G
I
R
E
K
N
D
V
Q
E
T
E
V
I
N
V
F
P
I
R
F
I
V
D
K
E
N
E
V
S
D
P
K
E
L
I
A
R
H
S
-
L
K
V
E
A
G
V
I
A
I
Q
----
K
S
I
---
L
I
N
M
I
K
C
V
E
A
C
G
V
D
V
L
D
V
Y
S
D
A
Y
N
Y
G
S
I
L
T
-
A
T
---------
E
K
E
L
G
A
C
V
I
---
D
I
G
E
D
V
T
Q
V
A
F
Y
E
R
-
G
E
L
V
D
A
D
S
I
E
M
-
A
G
-
R
D
I
T
D
D
I
A
Q
G
L
------------------
N
T
-
S
Y
E
T
A
E
K
V
K
H
Q
Y
G
H
A
F
Y
D
S
A
--
S
D
Q
D
I
F
T
V
E
-
Q
V
D
S
D
E
T
V
Q
Y
T
-
Q
K
D
L
S
D
F
I
E
A
R
V
E
E
I
F
F
E
V
F
D
---
V
L
----
Q
D
L
G
L
-------
T
K
-
V
-
N
G
G
F
I
V
T
G
G
S
A
N
L
L
G
V
K
E
L
L
S
D
M
V
S
--
E
K
V
R
I
H
-------
T
P
S
Q
M
-------------
G
I
R
K
-----
P
E
F
S
----------------
S
-
A
I
S
T
I
S
S
S
I
A
F
D
E
L
L
----------------------------------------------------------------------------------------------------------------------
21
PsiBlast_CBE
87.25
34%
-16
- C1 -
-
3WT0
1
FTSA_STAAW
D:
[21-377]
---
E
H
Y
Y
V
S
I
D
I
G
S
S
S
V
K
T
I
V
G
E
K
F
H
N
G
I
N
V
I
G
T
G
--
Q
T
--
Y
T
S
G
I
K
N
G
L
I
D
D
F
D
I
A
R
Q
A
I
K
D
T
I
K
K
A
S
I
A
S
G
V
D
I
-
K
E
-
V
F
L
K
L
P
--
I
I
G
T
E
V
Y
D
E
S
-
N
E
I
D
F
Y
E
D
T
-
E
I
N
G
S
H
I
E
K
V
L
E
G
I
R
E
K
N
D
V
Q
E
T
E
V
I
N
V
F
P
I
R
F
I
V
D
K
E
N
E
V
S
D
P
K
E
L
I
A
R
-
H
S
L
K
V
E
A
G
V
I
A
I
Q
----
K
S
I
---
L
I
N
M
I
K
C
V
E
A
C
G
V
D
V
L
D
V
Y
-
S
D
A
Y
N
Y
G
S
I
L
-
T
A
--
T
------
E
K
E
L
G
A
C
V
I
---
D
I
G
E
D
V
T
Q
V
A
F
Y
E
R
-
G
E
L
V
D
A
D
S
I
E
M
-
A
G
-
R
D
I
T
D
D
I
A
Q
G
L
------------------
N
T
-
S
Y
E
T
A
E
K
V
K
H
Q
Y
G
H
A
F
Y
D
S
A
--
S
D
Q
D
I
F
T
V
E
-
Q
V
D
S
D
E
T
V
Q
Y
T
-
Q
K
D
L
S
D
F
I
E
A
R
V
E
E
I
F
F
E
V
F
D
---
V
L
----
Q
D
L
G
L
-------
T
K
-
V
-
N
G
G
F
I
V
T
G
G
S
A
N
L
L
G
V
K
E
L
L
S
D
M
V
S
--
E
K
V
R
I
H
-------
T
P
S
Q
M
-------------
G
I
R
K
-----
P
E
F
--------------------------------------------------------------------------------------------------------------------------------------------------------
22
PsiBlast_CBE
86.02
34%
-19
- C1 -
-
3WT0
1
FTSA_STAAW
C:
[22-377]
----
H
Y
Y
V
S
I
D
I
G
S
S
S
V
K
T
I
V
G
E
K
F
H
N
G
I
N
V
I
G
T
G
--
Q
T
--
Y
T
S
G
I
K
N
G
L
I
D
D
F
D
I
A
R
Q
A
I
K
D
T
I
K
K
A
S
I
A
S
G
V
D
I
-
K
E
-
V
F
L
K
L
P
--
I
I
G
T
E
V
Y
D
E
S
-
N
E
I
D
F
Y
E
D
T
-
E
I
N
G
S
H
I
E
K
V
L
E
G
I
R
E
K
N
D
V
Q
E
T
E
V
I
N
V
F
P
I
R
F
I
V
D
K
E
N
E
V
S
D
P
K
E
L
I
A
R
-
H
S
L
K
V
E
A
G
V
I
A
I
Q
----
K
S
I
---
L
I
N
M
I
K
C
V
E
A
C
G
V
D
V
L
D
V
Y
-
S
D
A
Y
N
Y
G
S
I
L
-
T
A
--
T
------
E
K
E
L
G
A
C
V
I
---
D
I
G
E
D
V
T
Q
V
A
F
Y
E
R
-
G
E
L
V
D
A
D
S
I
E
M
-
A
G
-
R
D
I
T
D
D
I
A
Q
G
L
------------------
N
T
-
S
Y
E
T
A
E
K
V
K
H
Q
Y
G
H
A
F
Y
D
S
A
--
S
D
Q
D
I
F
T
V
E
-
Q
V
D
S
D
E
T
V
Q
Y
T
-
Q
K
D
L
S
D
F
I
E
A
R
V
E
E
I
F
F
E
V
F
D
---
V
L
----
Q
D
L
G
L
-------
T
K
-
V
-
N
G
G
F
I
V
T
G
G
S
A
N
L
L
G
V
K
E
L
L
S
D
M
V
S
--
E
K
V
R
I
H
-------
T
P
S
Q
M
-------------
G
I
R
K
-----
P
E
F
--------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
84.49
29%
-16
- C1 -
-
3WQT
1
FTSA_STAAR
A:
[20-393]
----
H
Y
Y
V
S
I
D
I
G
S
S
S
V
K
T
I
V
G
E
K
F
H
N
G
I
N
V
I
G
T
G
--
Q
T
--
Y
T
S
G
I
K
N
G
L
I
D
D
F
D
I
A
R
Q
A
I
K
D
T
I
K
K
A
S
I
A
S
G
V
D
I
-
K
E
-
V
F
L
K
L
P
--
I
I
G
T
E
V
Y
D
E
S
-
N
E
I
D
F
Y
E
D
T
-
E
I
N
G
S
H
I
E
K
V
L
E
G
I
R
E
----
Q
E
T
E
V
I
N
V
F
P
I
R
F
I
V
D
K
E
N
E
V
S
D
P
K
E
L
I
A
R
-
H
S
L
K
V
E
A
G
V
I
A
I
Q
----
K
S
I
---
L
I
N
M
I
K
C
V
E
A
C
G
V
D
V
L
D
V
Y
-
S
D
A
Y
N
Y
G
S
I
L
-
T
A
--
T
------
E
K
E
L
G
A
C
V
I
---
D
I
G
E
D
V
T
Q
V
A
F
Y
E
R
-
G
E
L
V
D
A
D
S
I
E
M
-
A
G
-
R
D
I
T
D
D
I
A
Q
G
L
------------------
N
T
-
S
Y
E
T
A
E
K
V
K
H
Q
Y
G
H
A
F
Y
D
S
A
--
S
D
Q
D
I
F
T
V
E
-
Q
V
D
S
D
E
T
V
Q
Y
T
-
Q
K
D
L
S
D
F
I
E
A
R
V
E
E
I
F
F
E
V
F
D
---
V
L
----
Q
D
L
G
L
-------
T
K
-
V
-
N
G
G
F
I
V
T
G
G
S
A
N
L
L
G
V
K
E
L
L
S
D
M
V
S
--
E
K
V
R
I
H
-------
T
P
S
Q
M
-------------
G
I
R
K
-----
P
E
F
S
S
A
I
S
T
I
S
S
S
I
A
F
D
E
L
L
D
--------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
82.37
29%
-14
- C1 -
-
3WQU
1
FTSA_STAAR
A:
[20-393]
----
H
Y
Y
V
S
I
D
I
G
S
S
S
V
K
T
I
V
G
E
K
F
H
N
G
I
N
V
I
G
T
G
--
Q
T
--
Y
T
S
G
I
K
N
G
L
I
D
D
F
D
I
A
R
Q
A
I
K
D
T
I
K
K
A
S
I
A
S
G
V
D
I
-
K
E
-
V
F
L
K
L
P
--
I
I
G
T
E
V
Y
D
E
S
-
N
E
I
D
F
Y
E
D
T
-
E
I
N
G
S
H
I
E
K
V
L
E
G
I
R
E
----
Q
E
T
E
V
I
N
V
F
P
I
R
F
I
V
D
K
E
N
E
V
S
D
P
K
E
L
I
A
R
-
H
S
L
K
V
E
A
G
V
I
A
I
Q
----
K
S
I
---
L
I
N
M
I
K
C
V
E
A
C
G
V
D
V
L
D
V
Y
-
S
D
A
Y
N
Y
G
S
I
L
-
T
A
--
T
------
E
K
E
L
G
A
C
V
I
---
D
I
G
E
D
V
T
Q
V
A
F
Y
E
R
-
G
E
L
V
D
A
D
S
I
E
M
-
A
G
-
R
D
I
T
D
D
I
A
Q
G
L
------------------
N
T
-
S
Y
E
T
A
E
K
V
K
H
Q
Y
G
H
A
F
Y
D
S
A
--
S
D
Q
D
I
F
T
V
E
-
Q
V
D
S
D
E
T
V
Q
Y
T
-
Q
K
D
L
S
D
F
I
E
A
R
V
E
E
I
F
F
E
V
F
D
---
V
L
----
Q
D
L
G
L
-------
T
K
-
V
-
N
G
G
F
I
V
T
G
G
S
A
N
L
L
G
V
K
E
L
L
S
D
M
V
S
--
E
K
V
R
I
H
-------
T
P
S
Q
M
-------------
G
I
R
K
-----
P
E
F
S
S
A
I
S
T
I
S
S
S
I
A
F
D
E
L
L
D
--------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
78.01
23%
-28
- C1 -
-
1E4F
-
?
T:
[7-390]
---
T
V
F
Y
T
S
I
D
I
G
S
R
Y
I
K
G
L
V
L
G
K
R
D
Q
E
W
E
A
L
A
F
S
--
S
V
--
K
S
R
G
L
D
E
G
E
I
K
D
A
I
A
F
K
E
S
V
N
T
L
L
K
E
L
E
E
Q
L
Q
K
S
L
-
R
S
D
F
V
I
S
F
S
--
S
V
S
F
E
R
E
D
T
V
-
I
E
R
D
F
G
E
E
K
R
S
I
T
L
D
I
L
S
E
M
Q
S
E
A
L
E
K
L
K
E
N
G
K
T
P
L
H
I
F
S
K
R
Y
L
L
D
D
E
R
I
V
F
N
P
L
D
M
K
A
S
-
K
-
I
A
I
E
Y
T
S
I
V
V
P
----
L
K
V
YEM
F
Y
N
F
L
Q
D
T
V
K
S
P
F
Q
L
K
S
S
L
V
S
---
T
A
E
G
V
L
-
T
T
--
P
------
E
K
D
R
G
V
V
V
V
---
N
L
G
Y
N
F
T
G
L
I
A
Y
K
N
-
G
V
P
I
K
I
S
Y
V
P
V
-
G
M
-
K
H
V
I
K
D
V
S
A
V
L
------------------
D
T
-
S
F
E
E
S
E
R
L
I
I
T
H
G
N
A
V
Y
N
D
L
--
K
-
E
E
E
I
Q
Y
R
-
G
L
D
G
N
T
I
K
T
T
T
-
A
K
K
L
S
V
I
I
H
A
R
L
R
E
I
M
S
K
S
K
K
FFR
E
V
----
E
A
K
---------
I
G
-
I
-
P
G
G
V
V
L
T
G
G
G
A
K
I
P
R
I
N
E
L
A
T
E
V
F
K
SP
V
R
T
G
C
Y
ANSDRPS
I
I
N
A
D
-------------
E
V
A
N
DPSFA
A
A
F
G
----------------
N
-
V
F
A
----------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
77.48
23%
-14
- C1 -
-
4A2B
1
?
A:
[7-392]
---
T
V
F
Y
T
S
I
D
I
G
S
R
Y
I
K
G
L
V
L
G
K
R
D
Q
E
W
E
A
L
A
F
S
--
S
V
--
K
S
R
G
L
D
E
G
E
I
K
D
A
I
A
F
K
E
S
V
N
T
L
L
K
E
L
E
E
Q
L
Q
K
S
L
-
R
S
D
F
V
I
S
F
S
--
S
V
S
F
E
R
E
D
T
V
-
I
E
R
D
F
G
E
E
K
R
S
I
T
L
D
I
L
S
E
M
Q
S
E
A
L
E
K
L
K
E
N
G
K
T
P
L
H
I
F
S
K
R
Y
L
L
D
D
E
R
I
V
F
N
P
L
D
M
K
A
S
-
K
-
I
A
I
E
Y
T
S
I
V
V
P
----
L
K
V
Y
E
M
F
Y
N
F
L
Q
D
T
V
K
S
P
F
Q
L
K
S
S
L
V
S
---
T
A
E
G
V
L
-
T
T
--
P
------
E
K
D
R
G
V
V
V
V
---
N
L
G
Y
N
F
T
G
L
I
A
Y
K
N
-
G
V
P
I
K
I
S
Y
V
P
V
-
G
M
-
K
H
V
I
K
D
V
S
A
V
L
------------------
D
T
-
S
F
E
E
S
E
R
L
I
I
T
H
G
N
A
V
Y
N
D
L
--
K
-
E
E
E
I
Q
Y
R
-
G
L
D
G
N
T
I
K
T
T
T
-
A
K
K
L
S
V
I
I
H
A
R
L
R
E
I
M
S
K
S
K
K
F
F
R
E
V
----
E
A
K
I
V
E
E
GE---
I
G
-
I
-
P
G
G
V
V
L
T
G
G
G
A
K
I
P
R
I
N
E
L
A
T
E
V
F
K
S
P
V
R
T
G
C
Y
ANSDRPS
I
I
N
A
D
-------------
E
V
A
N
DPSF
A
A
A
F
G
----------------
N
-
V
F
A
V
S
--------------------------------------------------------------------------------------------------------------------------------
53
Fugue
77.29
23%
-11
- C1 -
-
1E4F
-
?
T:
[7-390]
---
T
V
F
Y
T
S
I
D
I
G
S
R
Y
I
K
G
L
V
L
G
K
R
D
Q
E
W
E
A
L
A
F
S
--
S
V
--
K
S
R
G
L
D
E
G
E
I
K
D
A
I
A
F
K
E
S
V
N
T
L
L
K
E
L
E
E
Q
L
Q
K
S
L
-
R
S
D
F
V
I
S
F
S
--
S
V
S
F
E
R
E
D
T
V
-
I
E
R
D
F
G
E
E
K
R
S
I
T
L
D
I
L
S
E
M
Q
S
E
A
L
E
K
L
K
E
N
G
K
T
P
L
H
I
F
S
K
R
Y
L
L
D
D
E
R
I
V
F
N
P
L
D
M
K
A
S
-
K
-
I
A
I
E
Y
T
S
I
V
V
P
----
L
K
V
---
Y
E
M
F
Y
N
F
L
Q
D
T
V
K
S
P
F
Q
L
K
S
S
L
V
S
T
A
E
G
V
L
-
T
T
--
P
------
E
K
D
R
G
V
V
V
V
---
N
L
G
Y
N
F
T
G
L
I
A
Y
K
N
-
G
V
P
I
K
I
S
Y
V
P
V
-
G
M
-
K
H
V
I
K
D
V
S
A
V
L
------------------
D
T
-
S
F
E
E
S
E
R
L
I
I
T
H
G
N
A
V
Y
N
D
L
--
K
-
E
E
E
I
Q
Y
R
-
G
L
D
G
N
T
I
K
T
T
T
-
A
K
K
L
S
V
I
I
H
A
R
L
R
E
I
M
S
K
S
K
K
---
F
F
----
R
E
V
E
A
-------
K
I
G
I
-
P
G
G
V
V
L
T
G
G
G
A
K
I
P
R
I
N
E
L
A
T
E
V
F
K
--
S
P
V
R
T
G
-------
C
Y
A
N
S
-------------
D
R
P
S
---------------------------
I
I
N
A
D
E
V
A
N
D
-------------------------------------------------------------------------------
P
S
F
A
A
A
F
G
N
V
F
A
--------------------------------
31
HHSearch
77.20
22%
-4
- C1 -
-
4A2B
1
?
A:
[7-392]
---
T
V
F
Y
T
S
I
D
I
G
S
R
Y
I
K
G
L
V
L
G
K
R
D
Q
E
W
E
A
L
A
F
S
--
S
V
--
K
S
R
G
L
D
E
G
E
I
K
D
A
I
A
F
K
E
S
V
N
T
L
L
K
E
L
E
E
Q
L
Q
K
S
L
R
S
D
-
F
V
I
S
F
S
--
S
V
S
F
E
R
E
D
T
V
-
I
E
R
D
F
G
E
E
K
R
S
I
T
L
D
I
L
S
E
M
Q
S
E
A
L
E
K
L
K
E
N
G
K
T
P
L
H
I
F
S
K
R
Y
L
L
D
D
E
R
I
V
F
N
P
L
D
M
K
A
S
-
K
-
I
A
I
E
Y
T
S
I
V
V
P
----
L
K
V
---
Y
E
M
F
Y
N
F
L
Q
D
T
V
K
S
P
F
Q
L
K
S
S
L
V
S
T
A
E
G
V
L
-
T
T
--
P
------
E
K
D
R
G
V
V
V
V
---
N
L
G
Y
N
F
T
G
L
I
A
Y
K
N
-
G
V
P
I
K
I
S
Y
V
P
V
-
G
M
-
K
H
V
I
K
D
V
S
A
V
L
------------------
D
T
-
S
F
E
E
S
E
R
L
I
I
T
H
G
N
A
V
Y
N
D
L
--
K
-
E
E
E
I
Q
Y
R
-
G
L
D
G
N
T
I
K
T
T
T
-
A
K
K
L
S
V
I
I
H
A
R
L
R
E
I
M
S
K
S
K
K
---
F
F
----
R
E
V
E
A
K
I
V
E
E
GE
I
G
-
I
-
P
G
G
V
V
L
T
G
G
G
A
K
I
P
R
I
N
E
L
A
T
E
V
F
K
--
S
P
V
R
T
G
-------
C
Y
A
N
S
DRPSIINA
D
E
---
V
A
N
D
-----
P
S
F
A
----------------
A
-
A
F
G
N
V
F
A
V
S
----------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
75.62
23%
-13
- C1 -
-
1E4G
1
?
T:
[6-392]
--
K
T
V
F
Y
T
S
I
D
I
G
S
R
Y
I
K
G
L
V
L
G
K
R
D
Q
E
W
E
A
L
A
F
S
--
S
V
--
K
S
R
G
L
D
E
G
E
I
K
D
A
I
A
F
K
E
S
V
N
T
L
L
K
E
L
E
E
Q
L
Q
K
S
L
-
R
S
D
F
V
I
S
F
S
--
S
V
S
F
E
R
E
D
T
V
-
I
E
R
D
F
G
E
E
K
R
S
I
T
L
D
I
L
S
E
M
Q
S
E
A
L
E
K
L
K
E
N
G
K
T
P
L
H
I
F
S
K
R
Y
L
L
D
D
E
R
I
V
F
N
P
L
D
M
K
A
S
-
K
-
I
A
I
E
Y
T
S
I
V
V
P
----
L
K
V
YEM
F
Y
N
F
L
Q
D
T
V
K
S
P
F
Q
L
K
S
S
L
V
S
---
T
A
E
G
V
L
-
T
T
--
P
------
E
K
D
R
G
V
V
V
V
---
N
L
G
Y
N
F
T
G
L
I
A
Y
K
N
-
G
V
P
I
K
I
S
Y
V
P
V
-
G
M
-
K
H
V
I
K
D
V
S
A
V
L
------------------
D
T
-
S
F
E
E
S
E
R
L
I
I
T
H
G
N
A
V
Y
N
D
L
--
K
-
E
E
E
I
Q
Y
R
-
G
L
D
G
N
T
I
K
T
T
T
-
A
K
K
L
S
V
I
I
H
A
R
L
R
E
I
M
S
K
S
K
K
FFR
E
V
----
E
A
K
----------
G
-
I
-
P
G
G
V
V
L
T
G
G
G
A
K
I
P
R
I
N
E
L
A
T
E
V
F
K
SP
V
R
T
G
C
Y
ANSDRPS
I
I
N
A
D
-------------
E
V
A
N
DPSFA
A
A
F
G
----------------
N
-
V
F
A
V
S
--------------------------------------------------------------------------------------------------------------------------------
30
HHSearch
74.67
22%
-10
- C1 -
-
4A2A
1
?
A:
[7-390]
---
T
V
F
Y
T
S
I
D
I
G
S
R
Y
I
K
G
L
V
L
G
K
----
W
E
A
L
A
F
S
--
S
V
--
K
S
R
G
L
D
E
G
E
I
K
D
A
I
A
F
K
E
S
V
N
T
L
L
K
E
L
E
E
Q
L
Q
K
S
L
R
S
D
-
F
V
I
S
F
S
--
S
V
S
F
E
R
E
D
T
V
-
I
E
R
D
F
G
E
E
K
R
S
I
T
L
D
I
L
S
E
M
Q
S
E
A
L
E
K
L
K
E
N
G
K
T
P
L
H
I
F
S
K
R
Y
L
L
D
D
E
R
I
V
F
N
P
L
D
M
K
A
S
-
K
-
I
A
I
E
Y
T
S
I
V
V
P
----
L
K
V
---
Y
E
M
F
Y
N
F
L
Q
D
T
V
K
S
P
F
Q
L
K
S
S
L
V
S
T
A
E
G
V
L
-
T
T
--
P
------
E
K
D
R
G
V
V
V
V
---
N
L
G
Y
N
F
T
G
L
I
A
Y
K
N
-
G
V
P
I
K
I
S
Y
V
P
V
-
G
M
-
K
H
V
I
K
D
V
S
A
V
L
------------------
D
T
-
S
F
E
E
S
E
R
L
I
I
T
H
G
N
A
V
Y
N
D
L
--
K
-
E
E
E
I
Q
Y
R
-
G
L
D
G
N
T
I
K
T
T
T
-
A
K
K
L
S
V
I
I
H
A
R
L
R
E
I
M
S
K
S
K
K
---
F
F
----
R
E
V
E
A
K---------
I
-
P
G
G
V
V
L
T
G
G
G
A
K
I
P
R
I
N
E
L
A
T
E
V
F
K
--
S
P
V
R
T
G
-------
C
Y
A
N
S
DRPSIINADE---
V
A
N
D
-----
P
S
F
A
----------------
A
-
A
F
G
N
V
F
A
------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
74.28
23%
-20
- C1 -
-
4A2A
1
?
A:
[7-390]
---
T
V
F
Y
T
S
I
D
I
G
S
R
Y
I
K
G
L
V
L
G
K
----
W
E
A
L
A
F
S
--
S
V
--
K
S
R
G
L
D
E
G
E
I
K
D
A
I
A
F
K
E
S
V
N
T
L
L
K
E
L
E
E
Q
L
Q
K
S
L
-
R
S
D
F
V
I
S
F
S
--
S
V
S
F
E
R
E
D
T
V
-
I
E
R
D
F
G
E
E
K
R
S
I
T
L
D
I
L
S
E
M
Q
S
E
A
L
E
K
L
K
E
N
G
K
T
P
L
H
I
F
S
K
R
Y
L
L
D
D
E
R
I
V
F
N
P
L
D
M
K
A
S
-
K
-
I
A
I
E
Y
T
S
I
V
V
P
----
L
K
V
Y
E
M
F
Y
N
F
L
Q
D
T
V
K
S
P
F
Q
L
K
S
S
L
V
S
---
T
A
E
G
V
L
-
T
T
--
P
------
E
K
D
R
G
V
V
V
V
---
N
L
G
Y
N
F
T
G
L
I
A
Y
K
N
-
G
V
P
I
K
I
S
Y
V
P
V
-
G
M
-
K
H
V
I
K
D
V
S
A
V
L
------------------
D
T
-
S
F
E
E
S
E
R
L
I
I
T
H
G
N
A
V
Y
N
D
L
--
K
-
E
E
E
I
Q
Y
R
-
G
L
D
G
N
T
I
K
T
T
T
-
A
K
K
L
S
V
I
I
H
A
R
L
R
E
I
M
S
K
S
K
K
F
F
R
E
V
----
E
A
K
------------
I
-
P
G
G
V
V
L
T
G
G
G
A
K
I
P
R
I
N
E
L
A
T
E
V
F
K
S
P
V
R
T
G
C
Y
ANSDRPS
I
I
N
A
D
-------------
E
V
A
N
DPSF
A
A
A
F
G
----------------
N
-
V
F
A
----------------------------------------------------------------------------------------------------------------------------------
32
HHSearch
67.25
18%
-8
- C1 -
-
2YCH
1
?
A:
[11-373]
--
P
R
V
E
A
L
G
L
E
I
G
A
S
A
L
K
L
V
E
V
S
G
N
P
P
--
A
L
K
A
L
A
S
R
P
T
--
P
P
G
L
L
M
E
G
M
V
A
E
P
A
A
L
A
Q
E
I
K
E
L
L
L
E
----
A
R
T
R
K
-
R
Y
-
V
V
T
A
L
S
--
N
L
A
V
I
L
R
P
I
Q
---
V
P
------
K
M
P
L
K
E
M
E
E
A
V
R
W
E
A
E
R
Y
I
P
-------
F
P
I
-
E
V
V
L
D
-
F
A
P
L
T
P
L
S
E
V
-
Q
E
-
G
-
E
Q
V
Q
V
M
V
A
A
A
R
----
Q
E
A
---
V
A
G
V
L
E
A
L
R
G
A
G
L
V
P
V
V
L
D
V
K
P
F
A
G
L
Y
P
L
E
-
A
R
L
A
E
------
E
P
D
R
V
F
L
V
L
---
D
I
G
A
E
S
T
S
L
V
L
L
R
G
-
D
K
P
L
A
V
R
V
L
T
L
-
S
G
-
K
D
F
T
E
A
I
A
R
S
F
------------------
N
L
-
D
L
L
A
A
E
E
V
K
R
T
Y
---------------------------------
G
R
I
Y
D
A
I
R
P
V
L
V
E
L
T
Q
E
L
R
R
---
S
L
----
E
F
F
R
I
Q
L--------
S
-
P
E
V
G
Y
L
L
G
G
G
S
K
L
R
G
L
A
S
L
L
T
D
T
L
G
--
V
N
L
E
P
V
-------
N
P
W
E
A
V
A
V
D
PKRFE
S
E
Q
L
Q
E
I
G
-----
P
E
F
A
----------------
V
-
A
L
G
L
A
L
R
G
V
----------------------------------------------------------------------------------------------------------------------------
50
HHSearch
66.32
21%
-129
- C1 -
-
3H1Q
1
?
B:
[25-272]
-
L
P
P
P
Y
K
V
G
V
D
L
G
T
A
D
I
V
L
V
V
T
D
Q
-
E
G
-
I
P
V
A
G
A
L
--
K
W
---
A
S
V
V
K
D
G
L
V
V
D
Y
I
G
A
I
Q
I
V
R
E
L
K
A
K
V
E
R
L
L
G
S
E
L
-
F
Q
-
A
A
T
A
I
P
--
P
G
--------------------------------------------------------
T
-------------------------
V
----
G
R
N
---
A
E
A
C
G
H
V
V
A
G
A
G
L
E
L
V
T
L
V
D
E
P
V
A
A
A
R
A
L
G
-
I
-------------
N
D
G
I
V
V
---
D
I
G
G
G
T
T
G
I
A
V
I
E
K
-
G
K
I
T
A
T
F
D
E
P
T
-
G
G
-
T
H
L
S
L
V
L
A
G
S
Y
------------------
K
I
-
P
F
E
E
A
E
T
I
K
K
D
F
S
R
H
------------------------------
R
E
I
M
R
V
V
R
P
V
I
E
K
M
A
L
I
V
K
E
---
V
I
----
K
N
Y
----------
D
-
Q
-
T
L
P
V
Y
V
V
G
G
T
A
Y
L
T
G
F
S
E
E
F
S
R
F
L
G
--
K
E
V
Q
V
P
---------------------------
I
H
-----
P
L
L
V
----------------
T
-
P
L
G
I
A
L
F
G
-----------------------------------------------------------------------------------------------------------------------------
34
HHSearch
60.13
21%
-5
- C1 -
-
5EQ6
1
?
A:
[11-355]
--
K
A
N
T
L
L
G
I
D
I
S
S
T
S
V
K
L
L
E
L
S
R
S
G
G
R
Y
K
V
E
A
Y
A
--
V
E
P
L
P
P
N
A
V
V
E
K
N
I
V
E
L
E
G
V
G
Q
A
L
S
R
V
L
V
----
K
A
K
T
N
L
-
K
S
-
A
V
V
A
V
A
--
G
S
A
V
I
T
K
T
I
E
---
M
E
A
-----
G
L
S
E
D
E
L
E
N
Q
L
K
I
E
A
D
Q
Y
I
P
-------
Y
P
L
E
E
V
A
I
D
-
F
E
V
Q
G
L
S
A
---
R
N
-
P
-
E
R
V
D
V
L
L
A
A
C
R
----
K
E
N
---
V
E
V
R
E
A
A
L
A
L
A
G
L
T
A
K
V
V
D
V
E
A
Y
A
L
E
R
S
Y
A
-
L
L
--
S
SQLGAD
T
D
Q
L
T
V
A
V
V
---
D
I
G
A
T
M
T
T
L
S
V
L
H
N
-
G
R
T
I
Y
T
R
E
Q
L
F
-
G
G
-
R
Q
L
T
E
E
I
Q
R
R
Y
------------------
G
L
-
S
V
E
E
A
G
L
A
K
K
Q
G
G
L
P
D
D
-----------------------------
Y
D
S
E
V
L
R
P
F
K
D
A
V
V
Q
Q
V
S
R
---
S
L
----
Q
F
F
F
A
A
GQ----
F
N
-
D
-
V
D
Y
I
V
L
A
G
G
T
A
S
I
Q
D
L
D
R
L
I
Q
Q
K
I
G
--
T
P
T
L
V
A
-------
N
P
F
A
D
M
A
L
N
GKVN
A
G
A
L
-
A
S
D
A
-----
P
A
L
M
----------------
I
-
A
C
G
L
A
L
R
S
-----------------------------------------------------------------------------------------------------------------------------
60
Fugue
58.26
16%
12
- C1 -
-
5MB9
1
?
A:
[23-578]
--
G
E
R
V
V
I
G
I
T
F
G
N
S
N
S
S
I
--
A
H
T
V
D
D
K
A
E
V
I
--
A
--
N
E
--
D
G
D
R
Q
I
P
T
I
L
S
Y
V
D
G
D
E
Y
Y
G
Q
Q
A
K
N
F
L
V
R
N
P
K
N
T
V
-
A
Y
-
F
R
D
I
L
G
--
Q
D
F
K
S
V
D
P
T
H
-
N
H
---
A
S
A
H
P
Q
E
A
G
D
N
V
V
F
T
I
K
D
K
A
E
E
D
A
E
P
S
T
L
T
V
S
E
I
A
T
R
Y
L
R
R
L
V
G
A
A
S
E
Y
L
G
K
-------
K
V
T
S
A
V
I
T
I
P
TNFT
E
K
Q
---
K
A
A
L
I
A
A
A
A
A
A
D
L
E
V
L
Q
L
I
S
E
P
A
A
A
V
L
A
Y
D
-
A
R
--
P
------
E
A
T
I
S
D
K
I
I
V
V
A
D
L
G
G
S
R
S
D
V
T
V
L
A
S
-
R
S
G
M
Y
T
I
L
A
T
V
-
H
D
Y
E
Y
H
G
I
A
L
D
K
V
L
I
D
H
F
S
K
E
F
L
K
K
N
PGAKDP
R
E
-
N
P
R
S
L
A
K
L
R
L
E
A
E
S
T
K
R
A
L
S
R
S
T
-
N
A
S
F
S
V
E
S
L
I
D
G
L
D
F
A
S
T
I
N
R
L
R
Y
E
T
I
A
R
T
V
F
E
G
F
N
R
L
V
E
S
---
A
V
----
K
K
A
G
L
-------
D
P
-
L
D
V
D
E
V
I
M
S
G
G
T
S
N
T
P
R
I
A
A
N
F
R
Y
I
F
P
--
E
S
T
R
I
L
-------
A
P
S
T
-----------------
D
-----
P
S
-
A
----------------
L
-
N
P
S
E
L
Q
A
R
G
A
A
L
Q
A
S
L
I
Q
E
-
F
E
T
E
D
I
E
Q
S
T
H
A
A
V
T
T
M
P
H
V
T
N
A
I
G
V
V
S
V
S
K
F
V
P
I
I
A
P
E
T
AVP
A
R
R
T
V
H
G
G
D
V
L
V
K
V
V
E
G
S
T
-
H
I
N
V
I
K
R
E
K
V
W
K
I
G
S
T
L
A
E
A
A
V
R
G
VKKGA
K
V
E
V
T
I
N
V
N
TDL
T
V
I
V
T
A
R
E
V
59
Fugue
52.43
16%
-10
- C1 -
-
4I6M
-
ARP9_YEAST
B:
[3-439]
P
F
R
Q
D
S
I
--
L
I
I
Y
P
R
S
Q
T
T
L
V
Q
F
G
L
N
E
E
------------------------
T
F
T
V
P
E
L
E
I
P
T
Q
I
Y
R
T
T
R
Q
D
G
-
S
Y
-
T
Y
-
H
S
T
N
K
D
--
N
K
A
E
L
I
K
P
I
Q
N
G
E
I
I
D
I
S
A
F
T
Q
F
L
R
L
I
F
V
S
I
L
S
D
R
A
N
K
N
Q
D
A
F
E
A
E
L
S
N
I
P
L
L
L
I
T
H
H
S
W
S
Q
S
D
L
E
I
I
T
Q
Y
-
V
-
F
E
------------------------------
S
L
E
I
N
N
L
I
Q
L
P
A
S
L
A
A
T
Y
S
M
I
S
--
L
------
Q
N
---
C
C
I
I
---
D
V
G
T
H
H
T
D
I
I
P
I
V
D
Y
A
Q
L
D
H
L
V
S
S
I
P
M
G
G
-
Q
S
I
N
D
S
L
K
K
L
L
------------------
P
Q
W
D
D
D
Q
I
E
S
L
K
K
S
P
I
F
E
V
L
S
K
N
--
S
-
D
L
E
F
N
T
F
-
W
D
E
K
G
N
E
I
K
V
G
-
K
Q
R
F
Q
G
C
-
N
N
L
I
K
N
I
S
N
R
V
G
L
---
T
L
D
N
ID
D
I
N
K
A
-------
K
A
-
V
-
W
E
N
I
I
I
V
G
G
T
T
S
I
S
G
F
K
E
A
L
L
G
Q
L
L
--
K
D
H
L
I
I
-------
E
P
E
E
E
-------------
K
S
K
R
-----
E
E
E
A
----------------
K
S
F
V
P
T
I
E
Y
V
Q
C
P
T
V
I
K
L
A
K
Y
P
D
Y
F
P
E
W
K
K
S
G
Y
S
E
I
I
F
L
G
A
Q
I
V
S
K
Q
I
F
T
H
--------------------
P
K
D
T
F
Y
I
T
R
E
K
Y
N
M
K
G
P
A
A
L
W
D
V
Q
F
---------------------------------------