@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : spr1514: (2018-01-13 )
MKLTIHEIAQVVGAKNDISIFEDTQLEKAEFDSRLIGTGDLFVPLKGARDGHDFIETAFENGAAVTLSEKEVSNHPYILVDDVLTAFQSLASYYLEKTTVDVFAVTGSNGKTTTKDMLAHLLSTRYKTYKTQGNYNNEIGLPYTVLHMPEGTEKLVLEMGQDHLGDIHLLSELARPKTAIVTLVGEAHLAFFKDRSEIAKGKMQIADGMASGSLLLAPADPIVEDYLPIDKKVVRFGQGAELEITDLVERKDSLTFKANFLEQALDLPVTGKYNATNAMIASYVALQEGVSEEQIRLAFQHLELTRNRTEWKKAANGADILSDVYNANPTAMKLILETFSAIPANEGGKKIAVLADMKELGDQSVQLHNQMILSLSPDVLDIVIFYGEDIAQLAQLASQMFPIGHVYYFKKTEDQDQFEDLVKQVKESLGAHDQILLKGSNSMNLAKLVESLENEDK
Atome Classification :
(20 SA)
.........10.......-.20........30........40.......-.-50........60........70.----.-..------...-.80..--......-------90......--..-100.......110.......120....----..---.-130-----.-......140--..-....-----.150.......160.......170.......180.......190.......200.......210......-.-220.......-----230-----......-..---240-.-........250........260-.--...--..--...270..---.....-280.......290.......300.......310..---------.--....320.......330.......340.......350.......360.......370.......-.-380.....-----..------.390---.........400.-......410---........-.420......----.430.--......440.......450.....
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MKL
T
I
H
E
I
A
Q
V
VGAKND
I
-
S
IFEDTQL
E
K
A
EFDSRLIGTG
D
L
F
V
PLKGA-R-D
G
H
D
F
I
E
T
A
F
ENG
A
A
V
T
L
S
E
K
EV----S-NH------
P
Y
I
-
L
V
D
D
V
--
L
T
A
F
Q
S
-------
L
A
S
Y
Y
L
EK--
T
T
-
V
D
V
F
A
V
TGSNGKT
T
T
K
D
M
L
A
H
L
L
S
T
R
Y
----
K
T
---
Y
-KTQ-----G-NYNNEIGL
P
--
Y
T
-
V
L
HM-----PE
G
T
E
K
L
V
L
E
M
G
Q
D
HLG
D
I
H
L
L
S
E
LARP
K
T
A
I
V
T
L
VGE
A
H
L
A
F
F
K
D
R
S
E
I
AKG
K
M
Q
I
ADGMASG
S
L
L
LAP-A-D
P
I
V
E
D
YLP
I
-----
D
K
------
K
V
V
RFG-QG---A---E-L
E
I
T
D
L
V
ER-KDS
L
T
F
K
A
N
F
---
L
--
E
Q
A
--LD--LPVTGKYN---
A
T
N
A
M
-
I
A
S
Y
V
A
L
Q
EGV
S
E
E
Q
I
R
L
A
F
Q
H
L
E
LTR
N
R
T
E
W
K
KA---------A--N
G
A
D
I
L
S
D
V
YNA
N
P
T
A
M
K
L
I
L
E
T
F
SAIPANEGG
K
K
I
A
V
L
A
D
M
K
E
LGD
Q
S
V
Q
L
H
N
Q
-
M
I
L
SLSP
D
-
V
-
L
D
-
I
V
I
FY-----
G
E
------
D
I
-----
A
Q
L
A
Q
L
A
S
QMFPI-
G
H
V
Y
Y
F
K-----KTE
D
Q
D
Q
F
-
E
D
L
V
K
Q
V
K
E
S----LGAH
D
--
Q
I
L
L
KGSNSM
N
L
A
K
L
V
E
S
L
ENEDK
2
PsiBlast_PDB
90.23
100%
-102
- C3 -
-
3ZM6
1
?
A:
[1-454]
M
K
L
T
I
H
E
I
A
Q
V
V
G
A
K
N
D
I
-
S
I
F
E
D
T
Q
L
E
K
A
E
F
D
S
R
L
I
G
T
G
D
L
F
V
P
L
K
G
A
-
R
-
D
G
H
D
F
I
E
T
A
F
E
N
G
A
A
V
T
L
S
E
K
E
V
----
S
-
N
H
------
P
Y
I
-
L
V
D
D
V
--
L
T
A
F
Q
S
-------
L
A
S
Y
Y
L
E
K
--
T
T
-
V
D
V
F
A
V
T
G
S
N
G
K
T
T
T
K
D
M
L
A
H
L
L
S
T
R
Y
----
K
T
---
Y
-
K
T
Q
-----
G
-
N
Y
N
N
E
I
G
L
P
--
Y
T
-
V
L
H
M
-----
P
E
G
T
E
K
L
V
L
E
M
G
Q
D
H
L
G
D
I
H
L
L
S
E
L
A
R
P
K
T
A
I
V
T
L
V
G
E
A
H
L
A
F
F
K
D
R
S
E
I
A
K
G
K
M
Q
I
A
D
G
M
A
S
G
S
L
L
L
A
P
-
A
-
D
P
I
V
E
D
Y
L
P
I
-----
D
K
------
K
V
V
R
F
G
-
Q
G
---
A
---
E
-
L
E
I
T
D
L
V
E
R
-
K
D
S
L
T
F
K
A
N
F
---
L
--
E
Q
A
--
L
D
--
L
P
V
T
G
K
Y
N
---
A
T
N
A
M
-
I
A
S
Y
V
A
L
Q
E
G
V
S
E
E
Q
I
R
L
A
F
Q
H
L
E
L
T
R
N
R
T
E
W
K
K
A
---------
A
--
N
G
A
D
I
L
S
D
V
Y
N
A
N
P
T
A
M
K
L
I
L
E
T
F
S
A
I
P
A
N
E
G
G
K
K
I
A
V
L
A
D
M
K
E
L
G
D
Q
S
V
Q
L
H
N
Q
-
M
I
L
S
L
S
P
D
-
V
-
L
D
-
I
V
I
F
Y
-----
G
E
------
D
I
-----
A
Q
L
A
Q
L
A
S
Q
M
F
P
I
-
G
H
V
Y
Y
F
K
-----
K
T
E
D
Q
D
Q
F
-
E
D
L
V
K
Q
V
K
E
S
----
L
G
A
H
D
--
Q
I
L
L
K
G
S
N
S
M
N
L
A
K
L
V
E
S
L
E
N
---
1
PsiBlast_PDB
90.01
100%
-104
- C3 -
-
3ZM5
1
?
A:
[1-454]
M
K
L
T
I
H
E
I
A
Q
V
V
G
A
K
N
D
I
-
S
I
F
E
D
T
Q
L
E
K
A
E
F
D
S
R
L
I
G
T
G
D
L
F
V
P
L
K
G
A
-
R
-
D
G
H
D
F
I
E
T
A
F
E
N
G
A
A
V
T
L
S
E
K
E
V
----
S
-
N
H
------
P
Y
I
-
L
V
D
D
V
--
L
T
A
F
Q
S
-------
L
A
S
Y
Y
L
E
K
--
T
T
-
V
D
V
F
A
V
T
G
S
N
G
K
T
T
T
K
D
M
L
A
H
L
L
S
T
R
Y
----
K
T
---
Y
-
K
T
Q
-----
G
-
N
Y
N
N
E
I
G
L
P
--
Y
T
-
V
L
H
M
-----
P
E
G
T
E
K
L
V
L
E
M
G
Q
D
H
L
G
D
I
H
L
L
S
E
L
A
R
P
K
T
A
I
V
T
L
V
G
E
A
H
L
A
F
F
K
D
R
S
E
I
A
K
G
K
M
Q
I
A
D
G
M
A
S
G
S
L
L
L
A
P
-
A
-
D
P
I
V
E
D
Y
L
P
I
-----
D
K
------
K
V
V
R
F
G
-
Q
G
---
A
---
E
-
L
E
I
T
D
L
V
E
R
-
K
D
S
L
T
F
K
A
N
F
---
L
--
E
Q
A
--
L
D
--
L
P
V
T
G
K
Y
N
---
A
T
N
A
M
-
I
A
S
Y
V
A
L
Q
E
G
V
S
E
E
Q
I
R
L
A
F
Q
H
L
E
L
T
R
N
R
T
E
W
K
K
A
---------
A
--
N
G
A
D
I
L
S
D
V
Y
N
A
N
P
T
A
M
K
L
I
L
E
T
F
S
A
I
P
A
N
E
G
G
K
K
I
A
V
L
A
D
M
K
E
L
G
D
Q
S
V
Q
L
H
N
Q
-
M
I
L
S
L
S
P
D
-
V
-
L
D
-
I
V
I
F
Y
-----
G
E
------
D
I
-----
A
Q
L
A
Q
L
A
S
Q
M
F
P
I
-
G
H
V
Y
Y
F
K
-----
K
T
E
D
Q
D
Q
F
-
E
D
L
V
K
Q
V
K
E
S
----
L
G
A
H
D
--
Q
I
L
L
K
G
S
N
S
M
N
L
A
K
L
V
E
S
L
E
N
---
4
PsiBlast_PDB
88.62
97%
-101
- C3 -
-
2AM2
1
?
A:
[2-454]
-
K
L
T
I
H
E
I
A
Q
V
V
G
A
K
N
D
I
-
S
I
F
E
D
T
Q
L
E
K
A
E
F
D
S
R
L
I
G
T
G
D
L
F
V
P
L
K
G
A
-
R
-
D
G
H
D
F
I
E
T
A
F
E
N
G
A
A
V
T
L
S
E
K
E
V
----
S
-
N
H
------
P
Y
I
-
L
V
D
D
V
--
L
T
A
F
Q
S
-------
L
A
S
Y
Y
L
E
K
--
T
T
-
V
D
V
F
A
V
T
G
S
N
G
K
T
T
T
K
D
M
L
A
H
L
L
S
T
R
Y
----
K
T
---
Y
-
K
T
Q
-----
G
-
N
Y
N
N
E
I
G
L
P
--
Y
T
-
V
L
H
M
-----
P
E
G
T
E
K
L
V
L
E
M
G
Q
D
H
L
G
D
I
H
L
L
S
E
L
A
R
P
K
T
A
I
V
T
L
V
G
E
A
H
L
A
F
F
K
D
R
S
E
I
A
K
G
K
M
Q
I
A
D
G
M
A
S
G
S
L
L
L
A
P
-
A
-
D
P
I
V
E
D
Y
L
P
I
-----
D
K
------
K
V
V
R
F
G
-
Q
G
---
A
---
E
-
L
E
I
T
D
L
V
E
R
-
K
D
S
L
T
F
K
A
N
F
---
L
--
E
Q
A
--
L
D
--
L
P
V
T
G
K
Y
N
---
A
T
N
A
M
-
I
A
S
Y
V
A
L
Q
E
G
V
S
E
E
Q
I
R
L
A
F
Q
H
L
E
L
T
R
N
R
T
E
W
K
K
A
---------
A
--
N
G
A
D
I
L
S
D
V
Y
N
A
N
P
T
A
M
K
L
I
L
E
T
F
S
A
I
P
A
N
E
G
G
K
K
I
A
V
L
A
D
M
K
E
L
G
D
Q
S
V
Q
L
H
N
Q
-
M
I
L
S
L
S
P
D
-
V
-
L
D
-
I
V
I
F
Y
-----
G
E
------
D
I
-----
A
Q
L
A
Q
L
A
S
Q
M
F
P
I
-
G
H
V
Y
Y
F
K
-----
K
T
E
D
Q
D
Q
F
-
E
D
L
V
K
Q
V
K
E
S
----
L
G
A
H
D
--
Q
I
L
L
K
G
S
N
S
M
N
L
A
K
L
V
E
S
L
E
N
---
3
PsiBlast_PDB
88.50
97%
-99
- C3 -
-
2AM1
2
?
A:
[2-454]
-
K
L
T
I
H
E
I
A
Q
V
V
G
A
K
N
D
I
-
S
I
F
E
D
T
Q
L
E
K
A
E
F
D
S
R
L
I
G
T
G
D
L
F
V
P
L
K
G
A
-
R
-
D
G
H
D
F
I
E
T
A
F
E
N
G
A
A
V
T
L
S
E
K
E
V
----
S
-
N
H
------
P
Y
I
-
L
V
D
D
V
--
L
T
A
F
Q
S
-------
L
A
S
Y
Y
L
E
K
--
T
T
-
V
D
V
F
A
V
T
G
S
N
G
K
T
T
T
K
D
M
L
A
H
L
L
S
T
R
Y
----
K
T
---
Y
-
K
T
Q
-----
G
-
N
Y
N
N
E
I
G
L
P
--
Y
T
-
V
L
H
M
-----
P
E
G
T
E
K
L
V
L
E
M
G
Q
D
H
L
G
D
I
H
L
L
S
E
L
A
R
P
K
T
A
I
V
T
L
V
G
E
A
H
L
A
F
F
K
D
R
S
E
I
A
K
G
K
M
Q
I
A
D
G
M
A
S
G
S
L
L
L
A
P
-
A
-
D
P
I
V
E
D
Y
L
P
I
-----
D
K
------
K
V
V
R
F
G
-
Q
G
---
A
---
E
-
L
E
I
T
D
L
V
E
R
-
K
D
S
L
T
F
K
A
N
F
---
L
--
E
Q
A
--
L
D
--
L
P
V
T
G
K
Y
N
---
A
T
N
A
M
-
I
A
S
Y
V
A
L
Q
E
G
V
S
E
E
Q
I
R
L
A
F
Q
H
L
E
L
T
R
N
R
T
E
W
K
K
A
---------
A
--
N
G
A
D
I
L
S
D
V
Y
N
A
N
P
T
A
M
K
L
I
L
E
T
F
S
A
I
P
A
N
E
G
G
K
K
I
A
V
L
A
D
M
K
E
L
G
D
Q
S
V
Q
L
H
N
Q
-
M
I
L
S
L
S
P
D
-
V
-
L
D
-
I
V
I
F
Y
-----
G
E
------
D
I
-----
A
Q
L
A
Q
L
A
S
Q
M
F
P
I
-
G
H
V
Y
Y
F
K
-----
K
T
E
D
Q
D
Q
F
-
E
D
L
V
K
Q
V
K
E
S
----
L
G
A
H
D
--
Q
I
L
L
K
G
S
N
S
M
N
L
A
K
L
V
E
S
L
E
N
---
34
HHSearch
80.22
96%
-38
- C3 -
-
3ZM6
1
?
A:
[1-454]
M
K
L
T
I
H
E
I
A
Q
V
V
G
A
K
N
D
I
-
S
I
F
E
D
T
Q
L
E
K
A
E
F
D
S
R
L
I
G
T
G
D
L
F
V
P
L
K
G
A
-
R
-
D
G
H
D
F
I
E
T
A
F
E
N
G
A
A
V
T
L
S
E
K
E
V
----
S
-
N
H
------
P
Y
I
-
L
V
D
D
V
--
L
T
A
F
Q
S
-------
L
A
S
Y
Y
L
E
K
--
T
T
-
V
D
V
F
A
V
T
G
S
N
G
K
T
T
T
K
D
M
L
A
H
L
L
S
T
R
Y
----
K
T
---
Y
-
K
T
Q
-----
G
-
N
Y
N
N
E
I
G
L
P
--
Y
T
-
V
L
H
M
-----
P
E
G
T
E
K
L
V
L
E
M
G
Q
D
H
L
G
D
I
H
L
L
S
E
L
A
R
P
K
T
A
I
V
T
L
V
G
E
A
H
L
A
F
F
K
D
R
S
E
I
A
K
G
K
M
Q
I
A
D
G
M
A
S
-
G
S
L
L
L
A
-
P
-
A
D
P
---
I
V
E
D
-----
Y
L
PIDK--
K
V
V
R
F
G
-
Q
G
---
A
---
E
-
L
E
I
T
D
L
V
E
R
-
K
D
S
L
T
F
K
A
N
F
---
L
--
E
Q
A
--
L
D
--
L
P
V
T
G
K
Y
N
---
A
T
N
A
M
-
I
A
S
Y
V
A
L
Q
E
G
V
S
E
E
Q
I
R
L
A
F
Q
H
L
E
L
T
R
N
R
T
E
W
K
K
A
---------
A
--
N
G
A
D
I
L
S
D
V
Y
N
A
N
P
T
A
M
K
L
I
L
E
T
F
S
A
I
P
A
N
E
G
G
K
K
I
A
V
L
A
D
M
K
E
L
G
D
Q
S
V
Q
L
H
N
Q
-
M
I
L
S
L
-
S
P
D
V
-
L
D
-
I
V
I
F
Y
-----
G
E
------
D
I
-----
A
Q
L
A
Q
L
A
S
Q
M
F
P
I
-
G
H
V
Y
Y
F
K
K
T
EDQ
D
-
Q
-
F
----
E
D
L
V
K
Q
V
K
E
S
----
L
G
A
H
D
--
Q
I
L
L
K
G
S
N
S
M
N
L
A
K
L
V
E
S
L
E
N
---
35
HHSearch
79.39
96%
-33
- C3 -
-
2AM1
2
?
A:
[1-454]
M
K
L
T
I
H
E
I
A
Q
V
V
G
A
K
N
D
I
-
S
I
F
E
D
T
Q
L
E
K
A
E
F
D
S
R
L
I
G
T
G
D
L
F
V
P
L
K
G
A
-
R
-
D
G
H
D
F
I
E
T
A
F
E
N
G
A
A
V
T
L
S
E
K
E
V
----
S
-
N
H
------
P
Y
I
-
L
V
D
D
V
--
L
T
A
F
Q
S
-------
L
A
S
Y
Y
L
E
K
--
T
T
-
V
D
V
F
A
V
T
G
S
N
G
K
T
T
T
K
D
M
L
A
H
L
L
S
T
R
Y
----
K
T
---
Y
-
K
T
Q
-----
G
-
N
Y
N
N
E
I
G
L
P
--
Y
T
-
V
L
H
M
-----
P
E
G
T
E
K
L
V
L
E
M
G
Q
D
H
L
G
D
I
H
L
L
S
E
L
A
R
P
K
T
A
I
V
T
L
V
G
E
A
H
L
A
F
F
K
D
R
S
E
I
A
K
G
K
M
Q
I
A
D
G
M
A
S
-
G
S
L
L
L
A
-
P
-
A
D
P
---
I
V
E
D
-----
Y
L
PIDK--
K
V
V
R
F
G
-
Q
G
---
A
---
E
-
L
E
I
T
D
L
V
E
R
-
K
D
S
L
T
F
K
A
N
F
---
L
--
E
Q
A
--
L
D
--
L
P
V
T
G
K
Y
N
---
A
T
N
A
M
-
I
A
S
Y
V
A
L
Q
E
G
V
S
E
E
Q
I
R
L
A
F
Q
H
L
E
L
T
R
N
R
T
E
W
K
K
A
---------
A
--
N
G
A
D
I
L
S
D
V
Y
N
A
N
P
T
A
M
K
L
I
L
E
T
F
S
A
I
P
A
N
E
G
G
K
K
I
A
V
L
A
D
M
K
E
L
G
D
Q
S
V
Q
L
H
N
Q
-
M
I
L
S
L
-
S
P
D
V
-
L
D
-
I
V
I
F
Y
-----
G
E
------
D
I
-----
A
Q
L
A
Q
L
A
S
Q
M
F
P
I
-
G
H
V
Y
Y
F
K
K
T
EDQ
D
-
Q
-
F
----
E
D
L
V
K
Q
V
K
E
S
----
L
G
A
H
D
--
Q
I
L
L
K
G
S
N
S
M
N
L
A
K
L
V
E
S
L
E
N
---
32
HHSearch
56.48
28%
-2
- C3 -
-
4QDI
4
?
A:
[18-471]
E
P
W
T
A
Q
Q
L
Q
Q
A
T
Q
G
Y
W
H
K
-
D
Q
I
P
Q
T
E
I
K
R
I
L
T
D
S
R
H
A
E
S
G
D
A
F
L
A
L
K
G
E
R
F
-
D
A
H
N
F
V
A
Q
V
V
A
N
G
C
Q
V
A
I
V
E
R
P
I
D---
A
-
E
I
------
A
Q
L
-
V
V
A
D
T
--
R
L
A
L
G
Q
-------
L
G
A
Y
R
R
E
Q
N
-
A
Q
-
L
K
V
I
A
L
T
G
S
S
G
K
T
T
T
K
E
M
L
G
S
I
L
S
R
L
A
----
P
T
---
L
-
I
T
R
-----
G
-
N
L
N
N
D
L
G
V
P
--
M
M
-
L
L
E
L
-----
R
K
E
H
Q
Y
A
V
M
E
L
G
A
N
H
Q
G
E
I
D
Y
T
S
K
I
V
Q
P
H
V
A
G
I
L
N
I
G
T
A
H
L
G
E
F
G
G
R
D
G
I
C
R
A
K
S
E
I
Y
R
H
I
L
P
Q
G
V
A
I
V
P
-
Q
-
Q
D
D
---
F
T
A
E
-----
I
R
E
A
A
KS
H
Q
I
M
S
F
G
-
E
G
---
G
---
D
-
V
F
A
T
E
I
E
L
L
-
P
Q
S
A
N
F
Q
L
H
T
PQ-
G
--
S
S
F
--
V
R
--
L
P
F
A
G
E
H
N
---
V
Q
N
A
T
-
A
A
V
A
F
A
L
A
L
G
V
S
L
E
D
I
V
K
G
L
E
Q
A
Q
G
A
K
G
R
L
N
F
I
Q
K
------------
A
P
H
L
F
I
D
D
T
Y
N
A
N
P
T
S
M
R
A
A
A
Q
V
L
L
Q
Q
----
N
G
I
K
V
M
V
M
G
D
I
G
E
L
G
D
S
S
W
Q
E
H
H
D
-
L
G
R
D
L
-
A
E
-
L
P
L
D
-
H
I
V
A
V
-----
G
Q
------
F
A
-----
S
A
A
L
E
G
A
G
L
H
S
---
T
K
L
K
A
F
Q
-------
T
-
Q
----
A
E
A
L
P
F
L
I
N
L
I
Q
TH
Q
P
Q
S
M
--
S
F
L
F
K
G
S
R
F
T
H
M
E
T
L
M
A
D
L
M
E
K
--
37
HHSearch
56.25
31%
-1
- C3 -
-
4CVM
5
?
A:
[3-451]
E
P
L
R
L
S
Q
L
T
V
A
L
D
A
R
L
I
----
G
E
D
A
V
F
S
A
V
S
T
D
S
R
A
I
G
P
G
E
L
F
I
A
L
S
G
P
R
F
-
D
G
H
D
Y
L
A
E
V
A
A
K
G
A
V
A
A
L
V
E
R
E
V
AD--
A
-
P
L
------
P
Q
L
-
L
V
R
D
T
--
R
A
A
L
G
R
-------
L
G
A
L
N
R
R
K
--
F
T
-
G
P
L
A
A
M
T
G
S
S
G
K
T
T
V
K
E
M
L
A
S
I
L
R
T
Q
A
GDAE
S
V
---
L
-
A
T
R
-----
G
-
N
L
N
N
D
L
G
V
P
--
L
T
-
L
L
Q
L
-----
A
P
Q
H
R
S
A
V
I
E
L
G
A
S
R
I
G
E
I
A
Y
T
V
E
L
T
R
P
H
V
A
I
I
T
N
A
G
T
A
H
V
---
G
G
P
E
K
I
V
E
A
K
G
E
I
L
E
G
L
A
A
D
G
T
A
V
L
N
-
L
-
D
D
K
---
A
F
D
T
-----
W
K
A
R
A
SG
R
P
L
L
T
F
S
-
L
D
RPQ
A
---
D
-
F
R
A
A
D
L
Q
R
D
A
R
G
C
M
G
F
R
L
Q
G
VA-
G
--
E
A
Q
--
V
Q
--
L
N
L
L
G
R
H
N
---
V
A
N
A
L
-
A
A
A
A
A
A
H
A
L
G
V
P
L
D
G
I
V
A
G
L
Q
A
L
Q
P
V
K
G
R
A
V
A
Q
L
T
---------
A
--
S
G
L
R
V
I
D
D
S
Y
N
A
N
P
A
S
M
L
A
A
I
D
I
L
S
G
F
----
S
G
R
T
V
L
V
L
G
D
M
G
-----
A
E
Q
A
H
R
E
-
V
G
A
Y
A
-
A
G
-
K
-
V
S
-
A
L
Y
A
V
-----
G
P
------
L
M
-----
A
H
A
V
Q
A
F
G
A
------
T
G
R
H
F
A
-------
D
-
Q
----
A
S
L
I
G
A
L
A
T
-----
E
D
P
T
T
--
T
I
L
I
K
G
S
R
S
A
A
M
D
K
V
V
A
A
L
C
----
33
HHSearch
55.12
28%
1
- C3 -
-
1GG4
-
B:
[502-947]
I
S
V
T
L
S
Q
L
T
D
I
L
N
G
E
L
Q
----
G
A
D
I
T
L
D
A
V
T
T
D
T
R
K
L
T
P
G
C
L
F
V
A
L
K
G
E
R
F
-
D
A
H
D
F
A
D
Q
A
K
A
G
G
A
G
A
L
L
V
S
R
P
L
D---
I
-
D
L
------
P
Q
L
-
I
V
K
D
T
--
R
L
A
F
G
E
-------
L
A
A
W
V
R
Q
Q
--
V
P
-
A
R
V
V
A
L
T
G
S
S
G
K
T
S
V
K
E
M
T
A
A
I
L
S
Q
C
G
----
N
T
---
L
-
Y
T
A
-----
G
-
N
L
N
N
D
I
G
V
P
--
M
T
-
L
L
R
L
-----
T
P
E
Y
D
Y
A
V
I
E
L
G
A
N
H
Q
G
E
I
A
W
T
V
S
L
T
R
P
E
A
A
L
V
N
N
L
A
--------
S
L
A
G
V
A
K
A
K
G
E
I
F
S
G
L
P
E
N
G
I
A
I
M
N
-
A
-
D
N
N
---
D
W
L
N
-----
W
Q
SVIGSR
K
V
W
R
F
S
-
P
N
AAN
S
---
D
-
F
T
A
T
N
I
H
V
T
-
S
H
G
T
E
F
T
L
Q
T
---
P
TG
S
V
D
--
V
L
--
L
P
L
P
G
R
H
N
---
I
A
N
A
L
-
A
A
A
A
L
S
M
S
V
G
A
T
L
D
A
I
K
A
G
L
A
N
L
K
A
V
P
G
R
L
F
P
I
Q
L
---------
A
--
E
N
Q
L
L
L
D
D
S
Y
N
A
N
V
G
S
M
T
A
A
V
Q
V
L
A
E
M
----
P
G
Y
R
V
L
V
V
G
D
M
A
E
L
G
A
E
S
E
A
C
H
V
Q
-
V
G
E
A
A
-
K
A
-
A
G
I
D
-
R
V
L
S
V
-----
G
K
------
Q
S
-----
H
A
I
S
T
A
S
G
V
-------
G
E
H
F
A
-------
D
-
K
----
T
A
L
I
T
R
L
K
L
L
----
I
A
E
Q
Q
VI
T
I
L
V
K
G
S
R
S
A
A
M
E
E
V
V
R
A
L
Q
----
36
HHSearch
54.59
31%
1
- C3 -
-
4CVK
5
?
A:
[3-451]
E
P
L
R
L
S
Q
L
T
V
A
L
D
A
R
L
I
----
G
E
D
A
V
F
S
A
V
S
T
D
S
R
A
I
G
P
G
E
L
F
I
A
L
S
G
P
R
F
-
D
G
H
D
Y
L
A
E
V
A
A
K
G
A
V
A
A
L
V
E
R
E
V
A---
A
-
P
L
------
P
Q
L
-
L
V
R
D
T
--
R
A
A
L
G
R
-------
L
G
A
L
N
R
R
K
--
F
T
-
G
P
L
A
A
M
T
G
S
S
G
K
T
T
V
K
E
M
L
A
S
I
L
R
T
Q
A
GDAE
S
V
---
L
-
A
T
R
-----
G
-
N
L
N
N
D
L
G
V
P
--
L
T
-
L
L
Q
L
-----
A
P
Q
H
R
S
A
V
I
E
L
G
A
S
R
I
G
E
I
A
Y
T
V
E
L
T
R
P
H
V
A
I
I
T
N
A
-------
F
G
G
P
E
K
I
V
E
A
K
G
E
I
L
E
G
L
A
A
D
G
T
A
V
L
N
-
L
-
D
D
K
---
A
F
D
T
-----
W
K
A
R
A
SG
R
P
L
L
T
F
S
-
L
D
RPQ
A
---
D
-
F
R
A
A
D
L
Q
R
D
A
R
G
C
M
G
F
R
L
Q
G
VA-
G
--
E
A
Q
--
V
Q
--
L
N
L
L
G
R
H
N
---
V
A
N
A
L
-
A
A
A
A
A
A
H
A
L
G
V
P
L
D
G
I
V
A
G
L
Q
A
L
Q
P
V
K
G
R
A
V
A
Q
L
T
---------
A
--
S
G
L
R
V
I
D
D
S
Y
N
A
N
P
A
S
M
L
A
A
I
D
I
L
S
G
F
----
S
G
R
T
V
L
V
L
G
D
M
G
-----
A
E
Q
A
H
R
E
-
V
G
A
Y
A
-
A
G
-
K
-
V
S
-
A
L
Y
A
V
-----
G
P
------
L
M
-----
A
H
A
V
Q
A
F
G
A
------
T
G
R
H
F
A
-------
D
-
Q
----
A
S
L
I
G
A
L
A
T
-----
E
D
P
T
T
--
T
I
L
I
K
G
S
R
S
A
A
M
D
K
V
V
A
A
L
C
----
8
PsiBlast_PDB
52.94
28%
15
- C3 -
-
1GG4
-
MURF_ECOLI
A:
[21-447]
-----------------------
D
I
T
L
D
A
V
T
T
D
T
R
K
L
T
P
G
C
L
F
V
A
L
K
G
E
-
R
F
D
A
H
D
F
A
D
Q
A
K
A
G
G
A
G
A
L
L
V
S
R
P
L
----
D
I
D
L
------
P
Q
L
-
I
V
K
D
T
--
R
L
A
F
G
E
-------
L
A
A
W
V
R
Q
Q
--
V
P
-
A
R
V
V
A
L
T
G
S
S
G
K
T
S
V
K
E
M
T
A
A
I
L
S
Q
C
G
----
N
T
---
L
-
Y
T
A
-----
G
-
N
L
N
N
D
I
G
V
P
--
M
T
-
L
L
R
L
-----
T
P
E
Y
D
Y
A
V
I
E
L
G
A
N
H
Q
G
E
I
A
W
T
V
S
L
T
R
P
E
A
A
L
V
N
N
L
A
--------
S
L
A
G
V
A
K
A
K
G
E
I
F
S
G
L
P
E
N
G
I
A
I
M
N
-
A
-
D
N
--
N
D
W
L
N
W
Q
S
V
I
G
S
R
------
K
V
W
R
F
S
-
P
N
---
A
ANS
D
-
F
T
A
T
N
I
H
V
T
-
S
H
G
T
E
F
T
L
Q
T
---
P
--
T
G
S
--
V
D
VL
L
P
L
P
G
R
H
N
---
I
A
N
A
L
-
A
A
A
A
L
S
M
S
V
G
A
T
L
D
A
I
K
A
G
L
A
N
L
K
A
V
P
G
R
L
F
P
I
Q
L
---------
A
--
E
N
Q
L
L
L
D
D
S
Y
N
A
N
V
G
S
M
T
A
A
V
Q
V
L
A
E
M
P
----
G
Y
R
V
L
V
V
G
D
M
A
E
L
G
A
E
S
E
A
C
H
V
Q
-
V
G
E
A
A
K
A
A
-
G
-
I
D
-
R
V
L
S
V
-----
G
K
------
Q
---------
S
H
A
I
S
T
A
S
G
V
-
G
E
-
H
F
A
D
-----
K
T
A
L
I
T
R
L
-
K
L
L
I
A
E
Q
Q
V
I
-----------
T
I
L
V
K
G
S
R
S
A
A
M
E
E
V
V
R
A
L
Q
----
5
PsiBlast_PDB
49.52
30%
33
- C3 -
-
3ZL8
2
?
A:
[11-422]
-------------------------------
L
N
S
K
E
V
R
E
G
D
V
F
V
A
V
K
G
K
-
R
F
D
G
H
D
F
I
D
E
A
L
R
N
G
A
Y
A
I
I
A
E
R
K
T
----
V
-
N
S
------
D
R
I
F
L
V
E
S
S
--
V
D
T
L
A
K
-------
L
A
R
E
K
L
G
N
--
F
S
-
G
T
V
V
G
V
T
G
S
S
G
K
T
T
T
K
E
I
L
Y
N
L
L
K
N
K
R
----
S
V
---
F
-
K
T
P
-----
G
-
N
M
N
T
E
Y
G
L
P
--
L
S
-
I
L
N
D
-----
Y
K
G
E
E
I
L
V
L
E
M
A
A
S
R
P
G
D
I
A
H
L
C
K
I
A
P
P
D
V
A
V
L
L
N
V
G
S
A
H
L
E
F
F
G
T
R
E
R
I
M
E
T
K
M
E
I
I
K
H
S
K
E
N
A
I
A
V
T
L
-
F
D
D
P
D
L
R
K
E
V
P
R
-----
Y
R
------
N
T
L
F
F
G
K
E
G
---
G
---
D
-
S
V
L
K
D
W
W
Y
Y
-
E
G
S
T
I
A
E
F
E
A
---
F
--
D
S
L
--
F
T
--
V
K
L
S
G
Y
W
N
---
G
G
Q
L
L
N
I
A
A
S
L
C
V
M
R
T
L
G
E
T
V
D
I
F
D
L
A
S
L
K
T
V
P
G
R
F
N
V
R
E
----------
K
--
K
G
V
L
I
V
D
D
T
Y
N
A
S
P
E
A
F
Q
T
S
I
E
A
L
L
R
F
P
----
G
K
K
F
A
V
V
G
A
M
K
E
L
G
E
R
S
K
E
F
H
E
E
-
L
G
E
R
L
--
N
-
V
-
L
D
G
V
Y
V
F
L
-----
S
E
------
P
E
-----
A
E
W
I
K
S
K
K
I
I
L
---------------
K
S
D
D
P
E
K
I
A
K
D
L
A
T
R
V
K
K
G
--------
D
--
V
V
L
F
K
A
S
R
A
V
R
I
E
R
V
L
E
M
F
E
K
E
--
38
HHSearch
48.99
29%
25
- C3 -
-
3ZL8
2
?
A:
[2-422]
----------------------
K
D
L
L
T
R
R
F
V
L
N
S
K
E
V
R
E
G
D
V
F
V
A
V
K
G
K
R
F
-
D
G
H
D
F
I
D
E
A
L
R
N
G
A
Y
A
I
I
A
E
R
K
T
V---
N
-
S
D
------
R
I
F
-
L
V
E
S
S
--
V
D
T
L
A
K
-------
L
A
R
E
K
L
G
N
--
F
S
-
G
T
V
V
G
V
T
G
S
S
G
K
T
T
T
K
E
I
L
Y
N
L
L
K
N
K
R
----
S
V
---
F
-
K
T
P
-----
G
-
N
M
N
T
E
Y
G
L
P
--
L
S
-
I
L
N
D
-----
Y
K
G
E
E
I
L
V
L
E
M
A
A
S
R
P
G
D
I
A
H
L
C
K
I
A
P
P
D
V
A
V
L
L
N
V
G
S
A
H
L
E
F
F
G
T
R
E
R
I
M
E
T
K
M
E
I
I
K
H
S
K
E
N
A
I
A
V
T
L
-
F
-
D
D
P
---
D
L
R
K
-----
E
V
PRYR--
N
T
L
F
F
G
-
K
E
G--
G
---
D
-
S
V
L
K
D
W
W
Y
Y
-
E
G
S
T
I
A
E
F
E
A
---
F
--
D
S
L
--
F
T
--
V
K
L
S
G
Y
W
N
G
G
Q
L
L
N
I
A
-
A
S
L
C
V
M
R
T
L
G
E
T
V
D
I
--
F
D
L
A
S
L
K
T
V
P
G
R
F
N
V
R
E
K
------------
K
G
V
L
I
V
D
D
T
Y
N
A
S
P
E
A
F
Q
T
S
I
E
A
L
L
R
F
----
P
G
K
K
F
A
V
V
G
A
M
K
E
L
G
E
R
S
K
E
F
H
E
E
-
L
G
E
R
L
-
N
V
-
L
D
G
V
-
Y
V
F
L
S
-----
E
P
------
E
A
-----
E
W
I
K
S
K
K
--------
I
I
L
K
S
D
-------
D
-
P
----
E
K
I
A
K
D
L
A
T
R
----
V
K
K
G
D
--
V
V
L
F
K
A
S
R
A
V
R
I
E
R
V
L
E
M
F
E
K
E
--
6
PsiBlast_PDB
47.96
30%
10
- C3 -
-
4QDI
4
?
A:
[41-408]
------------------------
T
E
I
K
R
I
L
T
D
S
R
H
A
E
S
G
D
A
F
L
A
L
K
G
E
-
R
F
D
A
H
N
F
V
A
Q
V
V
A
N
G
C
Q
V
A
I
V
E
R
P
I
----
D
-
A
E
I-----
A
Q
L
-
V
V
A
D
T
--
R
L
A
L
G
Q
-------
L
G
A
Y
R
R
E
Q
--
N
A
Q
L
K
V
I
A
L
T
G
S
S
G
K
T
T
T
K
E
M
L
G
S
I
L
S
R
L
A
----
P
T
---
L
-
I
T
R
-----
G
-
N
L
N
N
D
L
G
V
P
--
M
M
-
L
L
E
L
-----
R
K
E
H
Q
Y
A
V
M
E
L
G
A
N
H
Q
G
E
I
D
Y
T
S
K
I
V
Q
P
H
V
A
G
I
L
N
I
G
T
A
H
L
G
E
F
G
G
R
D
G
I
C
R
A
K
S
E
I
Y
R
H
I
L
P
Q
G
V
A
I
V
P
Q
Q
-
D
D
F
T
A
E
I
R
E
A
-----
A
K
S
H
----
Q
I
M
S
F
G
-
E
G
---
G
---
D
-
V
F
A
T
E
I
E
L
L
-
P
Q
S
A
N
F
Q
L
H
T
---
P
--
Q
G
S
S
F
V
R
--
L
P
F
A
G
E
H
N
---
V
Q
N
A
T
-
A
A
V
A
F
A
L
A
L
G
V
S
L
E
D
I
V
K
G
L
E
Q
A
Q
G
A
K
G
R
L
N
F
I
Q
K
---------
A
--
P
H
L
-
F
I
D
D
T
Y
N
A
N
P
T
S
M
R
A
A
A
Q
V
L
----
L
Q
Q
N
G
I
K
V
M
V
M
G
D
I
G
E
L
G
D
S
S
W
Q
E
H
H
D
-
L
G
R
D
L
A
E
L
-
P
-
L
D
-
H
I
V
A
V
-----
G
Q
---------------------------------------------------------------------------------------------
7
PsiBlast_PDB
47.90
30%
8
- C3 -
-
4ZIY
4
?
A:
[43-417]
------------------------
T
E
I
K
R
I
L
T
D
S
R
H
A
E
S
G
D
A
F
L
A
L
K
G
E
-
R
F
D
A
H
N
F
V
A
Q
V
V
A
N
G
C
Q
V
A
I
V
E
R
P
I
----
D
-
A
E
I-----
A
Q
L
-
V
V
A
D
T
--
R
L
A
L
G
Q
-------
L
G
A
Y
R
R
E
Q
--
N
A
Q
L
K
V
I
A
L
T
G
S
S
G
K
T
T
T
K
E
M
L
G
S
I
L
S
R
L
A
----
P
T
---
L
-
I
T
R
-----
G
-
N
L
N
N
D
L
G
V
P
--
M
M
-
L
L
E
L
-----
R
K
E
H
Q
Y
A
V
M
E
L
G
A
N
H
Q
G
E
I
D
Y
T
S
K
I
V
Q
P
H
V
A
G
I
L
N
I
G
T
A
H
---
F
G
G
R
D
G
I
C
R
A
K
S
E
I
Y
R
H
I
L
P
Q
G
V
A
I
V
P
Q
Q
-
D
D
F
T
A
E
I
R
E
A
-----
A
K
S
H
----
Q
I
M
S
F
G
-
A
G
---
G
---
D
-
V
F
A
T
E
I
E
L
L
-
P
Q
S
A
N
F
Q
L
H
T
---
P
--
Q
G
S
S
F
V
R
--
L
P
F
A
G
E
H
N
---
V
Q
N
A
T
-
A
A
V
A
F
A
L
A
L
G
V
S
L
E
D
I
V
K
G
L
E
Q
A
Q
G
A
K
G
R
L
N
F
I
Q
K
---------
T
--
P
H
L
-
F
I
D
D
T
Y
N
A
N
P
T
S
M
R
A
A
A
Q
V
L
----
L
Q
Q
N
G
I
K
V
M
V
M
G
D
I
G
E
L
---
S
W
Q
E
H
H
D
-
L
G
R
D
L
A
E
L
-
P
-
L
D
-
H
I
V
A
V
-----
G
Q
---------------------------------------------------------------------------------------------
41
HHSearch
46.59
22%
8
- C3 -
-
4BUB
1
MURE_THEMA
B:
[2-461]
---
N
I
S
T
I
V
S
N
L
K
D
L
I
L
E
V
R
A
P
Y
D
L
E
I
T
G
V
S
N
H
S
S
K
V
K
K
G
D
L
F
I
C
R
R
G
E
---
D
S
H
E
I
I
P
E
V
M
E
K
G
A
V
A
V
V
V
E
R
E
I
D---
L
-
D
F
------
P
Y
I
-
Q
V
F
D
S
--
R
Y
F
E
A
K
-------
V
A
S
L
F
F
E
D
PW
K
D
-
V
L
T
F
G
V
T
G
T
N
G
K
T
T
T
T
M
M
I
Y
H
M
L
T
S
L
G
----
E
R
G
S
V
L
-
T
T
A
V
K
R
I
L
G
N
S
Y
Y
D
D
I
T
T
P
D
A
I
T
-
I
L
S
A
M
K
E
N
R
E
G
G
G
K
F
F
A
L
E
V
S
S
H
A
L
--
V
Q
Q
R
V
E
G
V
R
F
D
V
G
I
F
T
N
I
S
R
D
H
L
D
F
H
G
T
F
E
N
Y
L
K
A
K
L
H
L
F
D
L
L
K
D
D
G
V
A
V
L
N
-
E
-
S
L
A
---
D
A
F
N
R----
K
S
------
R
K
I
T
F
G
-
T
S
KN-
A
---
D
-
Y
R
L
G
N
I
E
V
S
-
W
E
G
T
Q
F
V
L
E
T
---
P
D
G
L
L
K
--
V
F
--
T
R
A
I
G
D
F
N
---
A
Y
N
A
A
-
A
A
I
A
A
L
H
Q
L
G
Y
D
P
K
D
L
A
S
S
L
E
T
F
T
G
V
E
G
R
F
E
V
V
R
G
---------
A
KK
I
G
L
N
V
V
V
D
-
F
A
H
S
P
D
A
L
E
K
L
L
K
N
V
R
K
I
S
---
Q
G
R
V
I
V
V
F
G
A
G
G
N
---
S
D
-
R
G
K
R
P
M
M
S
E
V
A
-
S
K
-
L
-
A
D
-
V
V
I
L
T
-----
T
D
------
D
P
RGED
P
E
Q
I
M
E
D
L
I
K
G
I
D
K
R
K
P
Y
L
V
L
F
-------
D
-
R
----
R
E
A
I
E
T
A
L
T
I
----
A
N
R
G
D
--
S
V
V
I
A
G
R
G
H
E
R
Y
Q
I
I
---------
11
PsiBlast_PDB
39.94
33%
-169
- C3 -
-
4BUB
-
MURE_THEMA
A:
[32-103]
---------------------------------
S
S
K
V
K
K
G
D
L
F
I
C
R
R
--------
E
I
I
P
E
V
M
E
K
G
A
V
A
V
V
V
E
R
E
I
----
D
L
D
F
------
P
Y
I
-
Q
V
F
D
S
--
R
Y
F
E
A
K
-------
V
A
S
L
F
F
E
D
--
P
W
-
K
D
V
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
30
PsiBlast_CBE
36.23
40%
-120
- C3 -
-
1E8C
1
MURE_ECOLI
A:
[26-63]
-------------------------------
L
D
S
R
V
A
A
A
G
D
L
F
V
A
V
V
G
H
-
Q
A
D
G
R
R
Y
I
P
Q
A
I
A
Q
G
V
A
A
I
I
A
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
53
HHSearch
35.90
20%
4
- C3 -
-
4HV4
2
MURC_YERPE
B:
[121-478]
----------------------------------------------------------------------------------------------------------------------------
Y
-
R
H
G
I
A
V
A
G
T
H
G
K
T
T
T
T
A
M
L
S
S
I
Y
A
E
A
G
----
L
D
---
P
T
F
V
N
-----
G
-
G
L
----
V
K
A
--
A
G
-
T
H
A
R
-----
L
G
S
S
R
Y
L
I
A
E
A
D
E
S
D
A
S
-----
F
L
H
L
Q
P
M
V
A
I
V
T
N
I
E
A
D
------
D
F
E
N
L
K
Q
T
F
I
N
F
L
H
N
L
P
F
Y
G
R
A
V
M
C
-
I
-
D
D
P
---
V
V
R
E
-----
L
L
PRVG
R
-
H
I
T
T
Y
G
-
F
S
DD-
A
---
D
-
V
Q
I
A
S
Y
R
Q
E
-
G
P
Q
G
H
F
T
L
R
R
Q
DK
P
--
L
I
E
--
V
T
--
L
N
A
P
G
R
H
N
---
A
L
N
A
A
-
A
A
V
A
V
A
T
E
E
G
I
E
D
E
D
I
L
R
A
L
V
G
F
Q
G
T
G
R
R
F
D
F
L
G
N
F
P
LAPVNGK
E
--
G
S
A
M
L
V
D
D
-
Y
G
H
H
P
T
E
V
D
A
T
I
K
A
A
R
A
G
W
---
P
D
K
R
I
V
M
L
F
Q
P
H
R
Y
T
R
-
T
R
D
L
Y
D
D
-
F
A
N
V
L
-
S
Q
---
V
D
-
V
L
L
M
L
D
VYAA
G
E
PPIPGA
D
S
-----
R
A
L
C
R
T
I
R
N
R
G
K
--
L
D
P
I
L
V
P
-------
D
-
S
----
E
S
A
P
E
M
L
A
Q
I
----
L
N
G
E
D
--
L
I
L
V
Q
G
A
G
N
I
G
--
K
I
A
R
K
L
-----
43
HHSearch
35.59
23%
30
- C3 -
-
3LK7
-
MURD_STRA5
A:
[30-427]
-------------------------------------
K
L
G
A
I
V
T
V
N
D
G
K
P
F
-
D
E
N
P
T
A
Q
S
L
L
E
E
G
I
K
V
V
C
G
S
H
P
L
E
L
L
D
E
-
D
F
C
Y
M
I
K
N
P
G
I
-
P
Y
N
N
P
M
V
K
K
A
L
E
K
QI
P
V
L
T
E
V
E
L
A
Y
L
-
V
--
S
E
-
S
Q
L
I
G
I
T
G
S
N
G
K
T
T
T
T
T
M
I
A
E
V
L
N
A
G
G
----
Q
R
---
G
-
L
L
A
-----
G
-
N
----
I
G
F
P
--
A
S
E
V
V
Q
A
-----
A
N
D
K
D
T
L
V
M
E
L
S
S
F
Q
L
M
G
----
V
K
E
F
R
P
H
I
A
V
I
T
N
L
M
P
T
H
L
D
Y
H
G
S
F
E
D
Y
V
A
A
K
W
N
I
Q
N
Q
M
S
S
S
D
F
L
V
L
N
-
F
-
N
Q
G
---
I
S
K
E
-----
L
A
K
T
TK
A
-
T
I
V
P
F
S
-
T
T
EK-
V
---
D
G
A
Y
V
Q
D
------
K
Q
L
F
Y
K
G
E
N
---
I
--
M
S
V
--
D
D
--
I
G
V
P
G
S
H
N
---
V
E
N
A
L
-
A
T
I
A
V
A
K
L
A
G
I
S
N
Q
V
I
R
E
T
L
S
N
F
G
G
V
K
H
R
L
Q
S
L
G
K
---------
V
--
H
G
I
S
F
Y
N
D
S
K
S
T
N
I
L
A
T
Q
K
A
L
S
G
F
D
N
------
T
K
V
I
L
I
A
G
G
-
L
D
R
G
N
----
E
F
D
E
-
L
I
P
D
I
-
T
G
---
L
K
-
H
M
V
V
L
-----
G
E
------
S
A
-----
S
R
V
K
R
A
A
Q
K
A
G
V
---
T
Y
S
D
A
L
-------
D
-
V
----
R
D
A
V
H
K
A
Y
E
V
----
A
Q
Q
G
D
--
V
I
L
L
S
P
A
N
A
S
--------------