@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : spr1515: (2018-01-13 )
MKQTIILLYGGRSAEREVSVLSAESVMRAVDYDRFTVKTFFISQSGDFIKTQEFSHAPGQEDRLMTNETIDWDKKVAPSAIYEEGAVVFPVLHGPMGEDGSVQGFLEVLKMPYVGCNILSSSLAMDKITTKRVLESAGIAQVPYVAIVEGDDVTAKIAEVEEKLAYPVFTKPSNMGSSVGISKSENQEELRQALKLAFRYDSRVLVEQGVNAREIEVGLLGNYDVKSTLPGEVVKDVAFYDYDAKYIDNKVTMDIPAKISDDVVAVMRQNAETAFRAIGGLGLSRCDFFYTDKGEIFLNELNTMPGFTQWSMYPLLWENMGISYPELIERLVDLAKESFDKREAHLI
Atome Classification :
(54 SA)
.........10........20......---..30-.-.....--..--40........50...--------.-------------.-------------.--..-60-...----.--...---------------.70------..--.---..-----...-.80.....------.--..90........100.......110.......120.......130.....-.-.140.....-------.----.150..---.----....-160--........170.......180.......190.......200.......210-.-.......220.--..------....230..-----..-----...240.....--..-250.---------........260.......270.......280.......290.......300.......310.......320.......330.......340.....
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
M
K
Q
T
I
I
L
L
YGGRSAE
R
E
V
S
V
L
S
A
E
S
V
M
---
R
A
VD-Y-D
R
F
T
V
--
K
T
--
F
F
ISQSG
D
F
I
KTQEF--------S-------------H-------------A--PG-QE-DRL----M--TNE---------------TI-------DW--D---KK-----VA
P
-
S
A
I
YEEG
A
------
V
--
V
F
P
V
LHGPMGEDG
S
V
Q
G
F
L
E
V
LKMPYV
G
C
N
I
L
S
S
S
LAM
D
K
I
T
T
K
R
V
L
E
SA-G-IAQV
P
Y
V
A
I
-------
V
----EGDD
V
T
---
A
----
K
I
A
E
-
V
E
---
E
KLAYPVFTKPSNMGSSVGISKSE
N
Q
E
E
L
R
Q
A
L
K
L
A
F
RYD
S
R
V
L
V
E
QGV-N-
A
-
R
E
I
E
V
G
L
LGNY--DV------KSTL
P
G
E
V
V
-----
K
D
-----
V
AFYDYD
A
K
Y
I--D
N
-
K
--
V
---------
T
MDIPAKI
S
D
D
V
V
A
V
M
R
Q
N
A
E
T
A
F
R
A
I
GGLGLS
R
C
D
F
F
YTDKG
E
I
F
L
N
E
LNTMPGFTQWS
M
Y
P
L
L
W
E
NMGI
S
Y
P
E
L
I
E
R
L
V
D
L
A
K
E
SFDKREAHLI
1
PsiBlast_PDB
87.55
73%
-37
- C1 -
-
3K3P
-
DDL_STRMU
A:
[3-346]
-
K
E
T
L
V
L
L
Y
G
G
R
S
A
E
R
D
V
S
V
L
S
A
E
S
V
M
---
R
A
I
N
-
Y
-
D
N
F
L
V
--
K
T
--
Y
F
I
T
Q
A
G
D
F
I
K
T
Q
E
F
--------
D
-------------
S
-------------
Q
--
P
S
----
D
K
L
----
M
--
T
N
D
---------------
T
I
-------
I
A
--
S
---
Q
K
-----
I
K
P
-
S
D
I
Y
E
E
E
A
------
V
--
V
F
P
V
L
H
G
P
M
G
E
D
G
S
I
Q
G
F
L
E
V
L
K
M
P
Y
V
G
T
N
I
L
S
S
S
V
A
M
D
K
I
T
T
N
Q
V
L
E
S
A
-
T
T
I
P
Q
V
A
Y
V
A
L
-------
I
----
E
G
E
P
L
E
---
S
----
K
L
A
E
-
V
E
---
E
K
L
I
Y
P
V
F
V
K
P
A
N
------
I
S
K
A
E
N
R
T
D
L
K
Q
A
I
A
L
A
L
K
Y
D
S
R
V
L
I
E
Q
G
V
-
D
-
A
-
R
E
I
E
V
G
I
L
G
N
T
--
D
V
------
K
T
T
L
P
G
E
I
V
-----------------------------------------
T
M
A
I
P
A
E
I
D
P
V
I
V
E
K
M
R
D
Y
A
A
T
A
F
R
T
L
G
C
C
G
L
S
R
C
D
F
F
L
T
E
D
G
K
V
Y
L
N
E
L
N
T
M
P
G
F
T
--
S
M
Y
P
L
L
W
E
N
M
G
L
S
Y
S
V
L
I
E
E
L
V
S
L
A
K
E
M
F
D
K
R
E
S
---
105
HHSearch
85.92
72%
-28
- C1 -
-
3K3P
-
DDL_STRMU
B:
[3-346]
-
K
E
T
L
V
L
L
Y
G
G
R
S
A
E
R
D
V
S
V
L
S
A
E
S
V
M
---
R
A
I
N
-
Y
-
D
N
F
L
V
--
K
T
--
Y
F
I
T
Q
A
G
D
F
I
K
T
Q
E
F
--------
D
-------------
S
-------------
Q
PS-
D
K
L
M
-
T
N
D
----
T
--
I
I
A
---------------
S
----------------
Q
K
-----
I
K
P
-
S
D
I
Y
E
E
E
A
------
V
--
V
F
P
V
L
H
G
P
M
G
E
D
G
S
I
Q
G
F
L
E
V
L
K
M
P
Y
V
G
T
N
I
L
S
S
S
V
A
M
D
K
I
T
T
N
Q
V
L
E
S
A
T
T
-
I
P
Q
V
A
Y
V
A
L
-------
I
----
E
G
E
P
L
E
---
S
----
K
L
A
E
-
V
E
---
E
K
L
I
Y
P
V
F
V
K
P
A
N
-----
G
I
S
K
A
E
N
R
T
D
L
K
Q
A
I
A
L
A
L
K
Y
D
S
R
V
L
I
E
Q
G
V
-
D
-
A
-
R
E
I
E
V
G
I
L
G
N
T
--
D
V
------
K
T
T
L
P
G
E
I
V
-----------------------------------------
T
M
A
I
P
A
E
I
D
P
V
I
V
E
K
M
R
D
Y
A
A
T
A
F
R
T
L
G
C
C
G
L
S
R
C
D
F
F
L
T
E
D
G
K
V
Y
L
N
E
L
N
T
M
P
G
F
T
--
S
M
Y
P
L
L
W
E
N
M
G
L
S
Y
S
V
L
I
E
E
L
V
S
L
A
K
E
M
F
D
K
R
E
S
---
3
PsiBlast_PDB
74.04
46%
5
- C1 -
-
2I87
-
DDL_STAAC
A:
[3-351]
-
K
E
N
I
C
I
V
F
G
G
K
S
A
E
H
E
V
S
I
L
T
A
Q
N
V
L
---
N
A
I
D
-
K
-
D
K
Y
H
V
--
D
I
--
I
Y
I
T
N
D
G
D
W
R
K
Q
N
N
I
--------
T
-------------
A
-------------
E
--
I
K
-
S
T
-
D
E
L
----
H
LE
N
G
E
---------------
A
L
-------
E
I
--
S
---
Q
L
-----
L
K
E
-
S
S
S
G
Q
P
Y
D
------
A
--
V
F
P
L
L
H
G
P
N
G
E
D
G
T
I
Q
G
L
F
E
V
L
D
V
P
Y
V
G
N
G
V
L
S
A
A
S
S
M
D
K
L
V
M
K
Q
L
F
E
H
R
-
G
-
L
P
Q
L
P
Y
I
S
F
-------
L
R
S
--
E
Y
E
K
Y
E
---
H
----
N
I
L
K
L
V
N
---
D
K
L
N
Y
P
V
F
V
K
P
A
N
L
G
S
S
V
G
I
S
K
C
N
N
E
A
E
L
K
E
G
I
K
E
A
F
Q
F
D
R
K
L
V
I
E
Q
G
V
-
N
-
A
-
R
E
I
E
V
A
V
L
G
N
D
--
Y
P
------
E
A
T
W
P
G
E
V
V
-----
K
D
-----
V
A
F
----------------
V
---------
Q
L
Q
I
P
A
D
L
D
E
D
V
Q
L
T
L
R
N
M
A
L
E
A
F
K
A
T
D
C
S
G
L
V
R
A
D
F
F
V
T
E
D
N
Q
I
Y
I
N
E
T
N
A
M
P
G
F
T
A
F
S
M
Y
P
K
L
W
E
N
M
G
L
S
Y
P
E
L
I
T
K
L
I
E
L
A
K
E
R
H
Q
D
K
Q
K
N
--
21
PsiBlast_CBE
73.92
46%
3
- C1 -
-
2I80
1
DDL_STAAC
B:
[3-351]
-
K
E
N
I
C
I
V
F
G
G
K
S
A
E
H
E
V
S
I
L
T
A
Q
N
V
L
---
N
A
I
D
-
K
-
D
K
Y
H
V
--
D
I
--
I
Y
I
T
N
D
G
D
W
R
K
Q
N
N
I
--------
T
-------------
A
-------------
E
--
I
K
-
S
T
-
D
E
L
----
H
LE
N
G
E
---------------
A
L
-------
E
I
--
S
---
Q
L
-----
L
K
E
-
S
S
S
G
Q
P
Y
D
------
A
--
V
F
P
L
L
H
G
P
N
G
E
D
G
T
I
Q
G
L
F
E
V
L
D
V
P
Y
V
G
N
G
V
L
S
A
A
S
S
M
D
K
L
V
M
K
Q
L
F
E
H
R
-
G
-
L
P
Q
L
P
Y
I
S
F
-------
L
RS--
E
Y
E
K
Y
E
---
H
----
N
I
L
K
L
V
N
---
D
K
L
N
Y
P
V
F
V
K
P
A
N
L
G
S
S
V
G
I
S
K
C
N
N
E
A
E
L
K
E
G
I
K
E
A
F
Q
F
D
R
K
L
V
I
E
Q
G
V
-
N
-
A
-
R
E
I
E
V
A
V
L
G
N
D
--
Y
P
------
E
A
T
W
P
G
E
V
V
-----
K
D
-----
V
A
F
----------------
V
---------
Q
L
Q
I
P
A
D
L
D
E
D
V
Q
L
T
L
R
N
M
A
L
E
A
F
K
A
T
D
C
S
G
L
V
R
A
D
F
F
V
T
E
D
N
Q
I
Y
I
N
E
T
N
A
M
P
G
F
T
A
F
S
M
Y
P
K
L
W
E
N
M
G
L
S
Y
P
E
L
I
T
K
L
I
E
L
A
K
E
R
H
Q
D
K
Q
K
N
--
95
HHSearch
73.02
48%
2
- C1 -
-
2I87
-
DDL_STAAC
B:
[3-349]
-
K
E
N
I
C
I
V
F
G
G
K
S
A
E
H
E
V
S
I
L
T
A
Q
N
V
L
---
N
A
I
D
-
K
-
D
K
Y
H
V
--
D
I
--
I
Y
I
T
N
D
G
D
W
R
K
Q
N
N
I
--------
T
AEIKSTDE-----
L
-------------
H
--
L
E
-
N
G
-
E
-
L
----
E
--
I
S
Q
---------------
L
L
---------------
K
E
---------
S
S
S
G
Q
P
Y
D
------
A
--
V
F
P
L
L
H
G
P
--
E
D
G
T
I
Q
G
L
F
E
V
L
D
V
P
Y
V
G
N
G
V
L
S
A
A
S
S
M
D
K
L
V
M
K
Q
L
F
E
H
R
-
G
-
L
P
Q
L
P
Y
I
S
F
-------
L
----
R
S
E
Y
E
K
Y
E
-
H
----
N
I
L
K
L
V
N
---
D
K
L
N
Y
P
V
F
V
K
P
A
N
L
G
S
S
V
G
I
S
K
C
N
N
E
A
E
L
K
E
G
I
K
E
A
F
Q
F
D
R
K
L
V
I
E
Q
G
V
-
N
-
A
-
R
E
I
E
V
A
V
L
G
N
D
--
Y
P
------
E
A
T
W
P
G
E
V
V
-----
K
D
-----
V
A
F
----------------
V
---------
Q
L
Q
I
P
A
D
L
D
E
D
V
Q
L
T
L
R
N
M
A
L
E
A
F
K
A
T
D
C
S
G
L
V
R
A
D
F
F
V
T
E
D
N
Q
I
Y
I
N
E
T
N
A
M
P
G
F
T
A
F
S
M
Y
P
K
L
W
E
N
M
G
L
S
Y
P
E
L
I
T
K
L
I
E
L
A
K
E
R
H
Q
D
K
Q
----
2
PsiBlast_PDB
72.57
46%
3
- C1 -
-
2I80
1
DDL_STAAC
A:
[3-351]
-
K
E
N
I
C
I
V
F
G
G
K
S
A
E
H
E
V
S
I
L
T
A
Q
N
V
L
---
N
A
I
D
-
K
-
D
K
Y
H
V
--
D
I
--
I
Y
I
T
N
D
G
D
W
R
K
Q
N
N
I
--------
T
-------------
A
-------------
E
--
I
K
-
S
T
-
D
E
L
----
H
LE
N
G
E
---------------
A
L
-------
E
I
--
S
---
Q
L
-----
L
K
E
-
S
S
S
G
Q
P
Y
D
------
A
--
V
F
P
L
L
H
G
P
N
G
E
D
G
T
I
Q
G
L
F
E
V
L
D
V
P
Y
V
G
N
G
V
L
S
A
A
S
S
M
D
K
L
V
M
K
Q
L
F
E
H
R
-
G
-
L
P
Q
L
P
Y
I
S
F
-------
L
R
S
--
E
Y
E
K
Y
E
---
H
----
N
I
L
K
L
V
N
---
D
K
L
N
Y
P
V
F
V
K
P
A
N
L
G
S
S
V
G
I
S
K
C
N
N
E
A
E
L
K
E
G
I
K
E
A
F
Q
F
D
R
K
L
V
I
E
Q
G
V
-
N
-
A
-
R
E
I
E
V
A
V
L
G
N
D
--
Y
P
------
E
A
T
W
P
G
E
V
V
-----
K
D
-----
V
A
F
----------------
V
---------
Q
L
Q
I
P
A
D
L
D
E
D
V
Q
L
T
L
R
N
M
A
L
E
A
F
K
A
T
D
C
S
G
L
V
R
A
D
F
F
V
T
E
D
N
Q
I
Y
I
N
E
T
N
A
M
P
G
F
T
A
F
S
M
Y
P
K
L
W
E
N
M
G
L
S
Y
P
E
L
I
T
K
L
I
E
L
A
K
E
R
H
Q
D
K
Q
K
N
--
100
HHSearch
72.38
47%
0
- C1 -
-
2I80
1
DDL_STAAC
B:
[3-350]
-
K
E
N
I
C
I
V
F
G
G
K
S
A
E
H
E
V
S
I
L
T
A
Q
N
V
L
---
N
A
I
D
-
K
-
D
K
Y
H
V
--
D
I
--
I
Y
I
T
N
D
G
D
W
R
K
Q
N
N
I
--------
T
AEIKSTDE-----
L
-------------
H
--
L
E
-
N
G
-
E
A
L
----
E
--
I
S
Q
---------------
L
L
---------------
K
E
---------
S
S
S
G
Q
P
Y
D
------
A
--
V
F
P
L
L
H
G
P
N
G
E
D
G
T
I
Q
G
L
F
E
V
L
D
V
P
Y
V
G
N
G
V
L
S
A
A
S
S
M
D
K
L
V
M
K
Q
L
F
E
H
R
-
G
-
L
P
Q
L
P
Y
I
S
F
-------
L
----
R
S
E
Y
E
K
YEH
N
----
I
L
K
L
-
V
N
---
D
K
L
N
Y
P
V
F
V
K
P
A
N
L
G
S
S
V
G
I
S
K
C
N
N
E
A
E
L
K
E
G
I
K
E
A
F
Q
F
D
R
K
L
V
I
E
Q
G
V
-
N
-
A
-
R
E
I
E
V
A
V
L
G
N
D
--
Y
P
------
E
A
T
W
P
G
E
V
V
-----
K
D
-----
V
A
F
----------------
V
---------
Q
L
Q
I
P
A
D
L
D
E
D
V
Q
L
T
L
R
N
M
A
L
E
A
F
K
A
T
D
C
S
G
L
V
R
A
D
F
F
V
T
E
D
N
Q
I
Y
I
N
E
T
N
A
M
P
G
F
T
A
F
S
M
Y
P
K
L
W
E
N
M
G
L
S
Y
P
E
L
I
T
K
L
I
E
L
A
K
E
R
H
Q
D
K
Q
K
---
22
PsiBlast_CBE
72.35
46%
6
- C1 -
-
2I8C
1
DDL_STAAC
B:
[3-351]
-
K
E
N
I
C
I
V
F
G
G
K
S
A
E
H
E
V
S
I
L
T
A
Q
N
V
L
---
N
A
I
D
-
K
-
D
K
Y
H
V
--
D
I
--
I
Y
I
T
N
D
G
D
W
R
K
Q
N
N
I
--------
T
-------------
A
-------------
E
--
I
K
-
S
T
-
D
E
L
----
H
LE
N
G
E
---------------
A
L
-------
E
I
--
S
---
Q
L
-----
L
K
E
-
S
S
S
G
Q
P
Y
D
------
A
--
V
F
P
L
L
H
G
P
N
G
E
D
G
T
I
Q
G
L
F
E
V
L
D
V
P
Y
V
G
N
G
V
L
S
A
A
S
S
M
D
K
L
V
M
K
Q
L
F
E
H
R
-
G
-
L
P
Q
L
P
Y
I
S
F
-------
L
RS--
E
Y
E
K
Y
E
---
H
----
N
I
L
K
L
V
N
---
D
K
L
N
Y
P
V
F
V
K
P
A
N
L
G
S
S
V
G
I
S
K
C
N
N
E
A
E
L
K
E
G
I
K
E
A
F
Q
F
D
R
K
L
V
I
E
Q
G
V
-
N
-
A
-
R
E
I
E
V
A
V
L
G
N
D
--
Y
P
------
E
A
T
W
P
G
E
V
V
-----
K
D
-----
V
A
F
----------------
V
---------
Q
L
Q
I
P
A
D
L
D
E
D
V
Q
L
T
L
R
N
M
A
L
E
A
F
K
A
T
D
C
S
G
L
V
R
A
D
F
F
V
T
E
D
N
Q
I
Y
I
N
E
T
N
A
M
P
G
F
T
A
F
S
M
Y
P
K
L
W
E
N
M
G
L
S
Y
P
E
L
I
T
K
L
I
E
L
A
K
E
R
H
Q
D
K
Q
K
N
--
27
PsiBlast_CBE
72.24
41%
-45
- C1 -
-
2ZDQ
3
DDL_THET8
B:
[3-317]
----
V
L
L
I
A
G
G
V
S
P
E
H
E
V
S
L
L
S
A
E
G
V
L
---
R
H
I
P
-----
F
P
T
--
D
L
--
A
V
I
A
Q
D
G
R
W
L
L
G
E
K
A
--------
L
-------------
T
-------------
A
----------
L
----
E
--
A
K
A
---------------
A
P
-------
E
G
--
E
---
H
P
-----
F
P
P
-
P
L
S
W
E
R
Y
D
------
V
--
V
F
P
L
L
H
G
R
F
G
E
D
G
T
V
Q
G
F
L
E
L
L
G
K
P
Y
V
G
A
G
V
A
A
S
A
L
C
M
D
K
D
L
S
K
R
V
L
A
Q
A
-
G
-
V
P
V
V
P
W
V
A
V
-------
R
----
K
G
E
P
P
V
---
V
----
P
F
D
P
-
P
F
---
F
-------
V
K
P
A
N
T
G
S
S
V
G
I
S
R
V
E
R
F
Q
D
L
E
A
A
L
A
L
A
F
R
Y
D
E
K
A
V
V
E
K
A
L
-
S
-
P
V
R
E
L
E
V
G
V
L
G
N
V
--
F
G
------
E
A
S
P
V
G
E
V
R
-----
Y
E
-----
A
P
F
Y
D
Y
E
T
K
Y
T
--
P
G
-
R
--
A
---------
E
L
L
I
P
A
P
L
D
P
G
T
Q
E
T
V
Q
E
L
A
L
K
A
Y
K
V
L
G
V
R
G
M
A
R
V
D
F
F
L
A
E
-
G
E
L
Y
L
N
E
L
N
T
I
P
G
F
T
P
T
S
M
Y
P
R
L
F
E
A
G
G
V
A
Y
P
E
L
L
R
R
L
V
E
L
A
------------
11
PsiBlast_PDB
72.01
41%
-45
- C1 -
-
2ZDQ
3
DDL_THET8
A:
[3-317]
----
V
L
L
I
A
G
G
V
S
P
E
H
E
V
S
L
L
S
A
E
G
V
L
---
R
H
I
P
-----
F
P
T
--
D
L
--
A
V
I
A
Q
D
G
R
W
L
L
G
E
K
A
--------
L
-------------
T
-------------
A
----------
L
----
E
--
A
K
A
---------------
A
P
-------
E
G
--
E
---
H
P
-----
F
P
P
-
P
L
S
W
E
R
Y
D
------
V
--
V
F
P
L
L
H
G
R
F
G
E
D
G
T
V
Q
G
F
L
E
L
L
G
K
P
Y
V
G
A
G
V
A
A
S
A
L
C
M
D
K
D
L
S
K
R
V
L
A
Q
A
-
G
-
V
P
V
V
P
W
V
A
V
-------
R
----
K
G
E
P
P
V
---
V
----
P
F
D
P
-
P
F
---
F
-------
V
K
P
A
N
T
G
S
S
V
G
I
S
R
V
E
R
F
Q
D
L
E
A
A
L
A
L
A
F
R
Y
D
E
K
A
V
V
E
K
A
L
-
S
-
P
V
R
E
L
E
V
G
V
L
G
N
V
--
F
G
------
E
A
S
P
V
G
E
V
R
-----
Y
E
-----
A
P
F
Y
D
Y
E
T
K
Y
T
--
P
G
-
R
--
A
---------
E
L
L
I
P
A
P
L
D
P
G
T
Q
E
T
V
Q
E
L
A
L
K
A
Y
K
V
L
G
V
R
G
M
A
R
V
D
F
F
L
A
E
-
G
E
L
Y
L
N
E
L
N
T
I
P
G
F
T
P
T
S
M
Y
P
R
L
F
E
A
G
G
V
A
Y
P
E
L
L
R
R
L
V
E
L
A
------------
7
PsiBlast_PDB
71.84
41%
-49
- C1 -
-
2YZM
1
DDL_THET8
A:
[3-317]
----
V
L
L
I
A
G
G
V
S
P
E
H
E
V
S
L
L
S
A
E
G
V
L
---
R
H
I
P
-----
F
P
T
--
D
L
--
A
V
I
A
Q
D
G
R
W
L
L
G
E
K
A
--------
L
-------------
T
-------------
A
----------
L
----
E
--
A
K
A
---------------
A
P
-------
E
G
--
E
---
H
P
-----
F
P
P
-
P
L
S
W
E
R
Y
D
------
V
--
V
F
P
L
L
H
G
R
F
G
E
D
G
T
V
Q
G
F
L
E
L
L
G
K
P
Y
V
G
A
G
V
A
A
S
A
L
C
M
D
K
D
L
S
K
R
V
L
A
Q
A
-
G
-
V
P
V
V
P
W
V
A
V
-------
R
----
K
G
E
P
P
V
---
V
----
P
F
D
P
-
P
F
---
F
-------
V
K
P
A
N
T
G
S
S
V
G
I
S
R
V
E
R
F
Q
D
L
E
A
A
L
A
L
A
F
R
Y
D
E
K
A
V
V
E
K
A
L
-
S
-
P
V
R
E
L
E
V
G
V
L
G
N
V
--
F
G
------
E
A
S
P
V
G
E
V
R
-----
Y
E
-----
A
P
F
Y
D
Y
E
T
K
Y
T
--
P
G
-
R
--
A
---------
E
L
L
I
P
A
P
L
D
P
G
T
Q
E
T
V
Q
E
L
A
L
K
A
Y
K
V
L
G
V
R
G
M
A
R
V
D
F
F
L
A
E
-
G
E
L
Y
L
N
E
L
N
T
I
P
G
F
T
P
T
S
M
Y
P
R
L
F
E
A
G
G
V
A
Y
P
E
L
L
R
R
L
V
E
L
A
------------
4
PsiBlast_PDB
71.69
46%
6
- C1 -
-
2I8C
1
DDL_STAAC
A:
[3-351]
-
K
E
N
I
C
I
V
F
G
G
K
S
A
E
H
E
V
S
I
L
T
A
Q
N
V
L
---
N
A
I
D
-
K
-
D
K
Y
H
V
--
D
I
--
I
Y
I
T
N
D
G
D
W
R
K
Q
N
N
I
--------
T
-------------
A
-------------
E
--
I
K
-
S
T
-
D
E
L
----
H
LE
N
G
E
---------------
A
L
-------
E
I
--
S
---
Q
L
-----
L
K
E
-
S
S
S
G
Q
P
Y
D
------
A
--
V
F
P
L
L
H
G
P
N
G
E
D
G
T
I
Q
G
L
F
E
V
L
D
V
P
Y
V
G
N
G
V
L
S
A
A
S
S
M
D
K
L
V
M
K
Q
L
F
E
H
R
-
G
-
L
P
Q
L
P
Y
I
S
F
-------
L
R
S
--
E
Y
E
K
Y
E
---
H
----
N
I
L
K
L
V
N
---
D
K
L
N
Y
P
V
F
V
K
P
A
N
L
G
S
S
V
G
I
S
K
C
N
N
E
A
E
L
K
E
G
I
K
E
A
F
Q
F
D
R
K
L
V
I
E
Q
G
V
-
N
-
A
-
R
E
I
E
V
A
V
L
G
N
D
--
Y
P
------
E
A
T
W
P
G
E
V
V
-----
K
D
-----
V
A
F
----------------
V
---------
Q
L
Q
I
P
A
D
L
D
E
D
V
Q
L
T
L
R
N
M
A
L
E
A
F
K
A
T
D
C
S
G
L
V
R
A
D
F
F
V
T
E
D
N
Q
I
Y
I
N
E
T
N
A
M
P
G
F
T
A
F
S
M
Y
P
K
L
W
E
N
M
G
L
S
Y
P
E
L
I
T
K
L
I
E
L
A
K
E
R
H
Q
D
K
Q
K
N
--
13
PsiBlast_PDB
71.48
40%
-48
- C1 -
-
2YZG
-
DDL_THET8
A:
[3-317]
----
V
L
L
I
A
G
G
V
S
P
E
H
E
V
S
L
L
S
A
E
G
V
L
---
R
H
I
P
-----
F
P
T
--
D
L
--
A
V
I
A
Q
D
G
R
W
L
L
G
E
K
A
--------
L
-------------
T
-------------
A
----------
L
----
E
--
A
K
A
---------------
A
P
-------
E
G
--
E
---
H
P
-----
F
P
P
-
P
L
S
W
E
R
Y
D
------
V
--
V
F
P
L
L
H
G
R
F
G
E
D
G
T
V
Q
G
F
L
E
L
L
G
K
P
Y
V
G
A
G
V
A
A
S
A
L
C
M
D
K
D
L
S
K
R
V
L
A
Q
A
-
G
-
V
P
V
V
P
W
V
A
V
-------
R
----
K
G
E
P
P
V
---
V
----
P
F
D
P
-
P
F
---
F
-------
V
K
P
A
N
T
G
S
S
V
G
I
S
R
V
E
R
F
Q
D
L
E
A
A
L
A
L
A
F
R
Y
D
E
K
A
V
V
E
K
A
L
-
S
-
P
V
R
E
L
E
V
G
V
L
G
N
V
--
F
G
------
E
A
S
P
V
G
E
V
R
-----
Y
E
-----
A
P
F
Y
D
Y
E
T
K
Y
T
--
P
G
-
R
--
A
---------
E
L
L
I
P
A
P
L
D
P
G
T
Q
E
T
V
Q
E
L
A
L
K
A
Y
K
V
L
G
V
R
G
M
A
R
V
D
F
F
L
A
E
-
G
E
L
Y
L
N
E
L
N
T
I
P
G
F
T
P
T
S
M
Y
P
R
L
F
E
A
G
G
V
A
Y
P
E
L
L
R
R
L
V
E
L
A
------------
12
PsiBlast_PDB
71.14
41%
-48
- C1 -
-
2FB9
-
DDL_THET8
A:
[6-320]
----
V
L
L
I
A
G
G
V
S
P
E
H
E
V
S
L
L
S
A
E
G
V
L
---
R
H
I
P
-----
F
P
T
--
D
L
--
A
V
I
A
Q
D
G
R
W
L
L
G
E
K
A
--------
L
-------------
T
-------------
A
----------
L
----
E
--
A
K
A
---------------
A
P
-------
E
G
--
E
---
H
P
-----
F
P
P
-
P
L
S
W
E
R
Y
D
------
V
--
V
F
P
L
L
H
G
R
F
G
E
D
G
T
V
Q
G
F
L
E
L
L
G
K
P
Y
V
G
A
G
V
A
A
S
A
L
C
M
D
K
D
L
S
K
R
V
L
A
Q
A
-
G
-
V
P
V
V
P
W
V
A
V
-------
R
----
K
G
E
P
P
V
---
V
----
P
F
D
P
-
P
F
---
F
-------
V
K
P
A
N
T
G
S
S
V
G
I
S
R
V
E
R
F
Q
D
L
E
A
A
L
A
L
A
F
R
Y
D
E
K
A
V
V
E
K
A
L
-
S
-
P
V
R
E
L
E
V
G
V
L
G
N
V
--
F
G
------
E
A
S
P
V
G
E
V
R
-----
Y
E
-----
A
P
F
Y
D
Y
E
T
K
Y
T
--
P
G
-
R
--
A
---------
E
L
L
I
P
A
P
L
D
P
G
T
Q
E
T
V
Q
E
L
A
L
K
A
Y
K
V
L
G
V
R
G
M
A
R
V
D
F
F
L
A
E
-
G
E
L
Y
L
N
E
L
N
T
I
P
G
F
T
P
T
S
M
Y
P
R
L
F
E
A
G
G
V
A
Y
P
E
L
L
R
R
L
V
E
L
A
------------
28
PsiBlast_CBE
71.13
41%
-46
- C1 -
-
2ZDH
2
DDL_THET8
D:
[3-317]
----
V
L
L
I
A
G
G
V
S
P
E
H
E
V
S
L
L
S
A
E
G
V
L
---
R
H
I
P
-----
F
P
T
--
D
L
--
A
V
I
A
Q
D
G
R
W
L
L
G
E
K
A
--------
L
-------------
T
-------------
A
----------
L
----
E
--
A
K
A
---------------
A
P
-------
E
G
--
E
---
H
P
-----
F
P
P
-
P
L
S
W
E
R
Y
D
------
V
--
V
F
P
L
L
H
G
R
F
G
E
D
G
T
V
Q
G
F
L
E
L
L
G
K
P
Y
V
G
A
G
V
A
A
S
A
L
C
M
D
K
D
L
S
K
R
V
L
A
Q
A
-
G
-
V
P
V
V
P
W
V
A
V
-------
R
----
K
G
E
P
P
V
---
V
----
P
F
D
P
-
P
F
---
F
-------
V
K
P
A
N
T
G
S
S
V
G
I
S
R
V
E
R
F
Q
D
L
E
A
A
L
A
L
A
F
R
Y
D
E
K
A
V
V
E
K
A
L
-
S
-
P
V
R
E
L
E
V
G
V
L
G
N
V
--
F
G
------
E
A
S
P
V
G
E
V
R
-----
Y
E
-----
A
P
F
Y
D
Y
E
T
K
Y
T
--
P
G
-
R
--
A
---------
E
L
L
I
P
A
P
L
D
P
G
T
Q
E
T
V
Q
E
L
A
L
K
A
Y
K
V
L
G
V
R
G
M
A
R
V
D
F
F
L
A
E
-
G
E
L
Y
L
N
E
L
N
T
I
P
G
F
T
P
T
S
M
Y
P
R
L
F
E
A
G
G
V
A
Y
P
E
L
L
R
R
L
V
E
L
A
------------
9
PsiBlast_PDB
71.11
41%
-50
- C1 -
-
2ZDG
1
DDL_THET8
A:
[3-317]
----
V
L
L
I
A
G
G
V
S
P
E
H
E
V
S
L
L
S
A
E
G
V
L
---
R
H
I
P
-----
F
P
T
--
D
L
--
A
V
I
A
Q
D
G
R
W
L
L
G
E
K
A
--------
L
-------------
T
-------------
A
----------
L
----
E
--
A
K
A
---------------
A
P
-------
E
G
--
E
---
H
P
-----
F
P
P
-
P
L
S
W
E
R
Y
D
------
V
--
V
F
P
L
L
H
G
R
F
G
E
D
G
T
V
Q
G
F
L
E
L
L
G
K
P
Y
V
G
A
G
V
A
A
S
A
L
C
M
D
K
D
L
S
K
R
V
L
A
Q
A
-
G
-
V
P
V
V
P
W
V
A
V
-------
R
----
K
G
E
P
P
V
---
V
----
P
F
D
P
-
P
F
---
F
-------
V
K
P
A
N
T
G
S
S
V
G
I
S
R
V
E
R
F
Q
D
L
E
A
A
L
A
L
A
F
R
Y
D
E
K
A
V
V
E
K
A
L
-
S
-
P
V
R
E
L
E
V
G
V
L
G
N
V
--
F
G
------
E
A
S
P
V
G
E
V
R
-----------------------------------------
E
L
L
I
P
A
P
L
D
P
G
T
Q
E
T
V
Q
E
L
A
L
K
A
Y
K
V
L
G
V
R
G
M
A
R
V
D
F
F
L
A
E
-
G
E
L
Y
L
N
E
L
N
T
I
P
G
F
T
P
T
S
M
Y
P
R
L
F
E
A
G
G
V
A
Y
P
E
L
L
R
R
L
V
E
L
A
------------
93
HHSearch
70.85
38%
-30
- C- -
-
3E5N
-
?
A:
[2-358]
R
K
I
R
V
G
L
I
F
G
G
K
S
A
E
H
E
V
S
L
Q
S
A
R
N
I
L
---
D
A
L
D
-
P
-
Q
R
F
E
P
--
V
L
--
I
G
I
D
K
Q
G
Q
W
H
V
N
D
P
D
--------
S
-------------
F
-------------
L
--
L
H
-
A
D
D
P
A
R
----
I
--
A
L
H
RSGR
G
V
A
L
L
P
GAQQQ
Q
L
---------------
R
P
-----
I
Q
---
Q
A
L
A
Q
I
D
------
V
--
V
F
P
I
V
H
G
T
L
G
E
D
G
S
L
Q
G
L
L
R
M
A
N
L
P
F
V
G
S
G
V
L
G
S
A
V
A
M
D
K
D
M
A
K
R
V
L
R
D
A
-
R
-
L
A
V
A
P
F
V
C
F
-------
D
----
R
H
T
A
A
H
---
A
----
D
V
D
T
-
L
I
---
A
Q
L
G
L
P
L
F
V
K
P
A
N
Q
G
S
S
V
G
V
S
Q
V
R
T
A
D
A
F
A
A
A
L
A
L
A
L
A
Y
D
H
K
V
L
V
E
A
A
V
-
A
-
G
-
R
E
I
E
C
A
V
L
G
N
A
--
V
P
------
H
A
S
V
C
G
E
V
V
-----
V
-----------------------------------
E
I
V
I
P
A
D
I
D
A
Q
T
Q
Q
R
I
Q
Q
I
A
V
Q
A
Y
Q
A
L
G
C
A
G
M
A
R
V
D
V
F
L
C
A
D
G
R
I
V
I
N
E
V
N
T
L
P
G
F
T
R
I
S
V
Y
P
K
L
W
Q
A
S
G
L
D
Y
R
G
L
I
T
R
L
I
E
L
A
L
E
R
H
T
D
D
Q
----
10
PsiBlast_PDB
70.78
41%
-44
- C1 -
-
2ZDH
2
DDL_THET8
A:
[3-317]
----
V
L
L
I
A
G
G
V
S
P
E
H
E
V
S
L
L
S
A
E
G
V
L
---
R
H
I
P
-----
F
P
T
--
D
L
--
A
V
I
A
Q
D
G
R
W
L
L
G
E
K
A
--------
L
-------------
T
-------------
A
----------
L
----
E
--
A
K
A
---------------
A
P
-------
E
G
--
E
---
H
P
-----
F
P
P
-
P
L
S
W
E
R
Y
D
------
V
--
V
F
P
L
L
H
G
R
F
G
E
D
G
T
V
Q
G
F
L
E
L
L
G
K
P
Y
V
G
A
G
V
A
A
S
A
L
C
M
D
K
D
L
S
K
R
V
L
A
Q
A
-
G
-
V
P
V
V
P
W
V
A
V
-------
R
----
K
G
E
P
P
V
---
V
----
P
F
D
P
-
P
F
---
F
-------
V
K
P
A
N
T
G
S
S
V
G
I
S
R
V
E
R
F
Q
D
L
E
A
A
L
A
L
A
F
R
Y
D
E
K
A
V
V
E
K
A
L
-
S
-
P
V
R
E
L
E
V
G
V
L
G
N
V
--
F
G
------
E
A
S
P
V
G
E
V
R
-----
Y
E
-----
A
P
F
Y
D
Y
E
T
K
Y
T
--
P
G
-
R
--
A
---------
E
L
L
I
P
A
P
L
D
P
G
T
Q
E
T
V
Q
E
L
A
L
K
A
Y
K
V
L
G
V
R
G
M
A
R
V
D
F
F
L
A
E
-
G
E
L
Y
L
N
E
L
N
T
I
P
G
F
T
P
T
S
M
Y
P
R
L
F
E
A
G
G
V
A
Y
P
E
L
L
R
R
L
V
E
L
A
------------
30
PsiBlast_CBE
70.31
41%
-51
- C1 -
-
2ZDH
2
DDL_THET8
B:
[3-317]
----
V
L
L
I
A
G
G
V
S
P
E
H
E
V
S
L
L
S
A
E
G
V
L
---
R
H
I
P
-----
F
P
T
--
D
L
--
A
V
I
A
Q
D
G
R
W
L
L
G
E
K
A
--------
L
-------------
T
-------------
A
----------
L
----
E
--
A
K
A
---------------
A
P
-------
E
G
--
E
---
H
P
-----
F
P
P
-
P
L
S
W
E
R
Y
D
------
V
--
V
F
P
L
L
H
G
R
F
G
E
D
G
T
V
Q
G
F
L
E
L
L
G
K
P
Y
V
G
A
G
V
A
A
S
A
L
C
M
D
K
D
L
S
K
R
V
L
A
Q
A
-
G
-
V
P
V
V
P
W
V
A
V
-------
R
----
K
G
E
P
P
V
---
V
----
P
F
D
P
-
P
F
---
F
-------
V
K
P
A
N
T
G
S
S
V
G
I
S
R
V
E
R
F
Q
D
L
E
A
A
L
A
L
A
F
R
Y
D
E
K
A
V
V
E
K
A
L
-
S
-
P
V
R
E
L
E
V
G
V
L
G
N
V
--
F
G
------
E
A
S
P
V
G
E
V
R
-----
Y
E
-----
A
P
F
Y
---------
P
G
-
R
--
A
---------
E
L
L
I
P
A
P
L
D
P
G
T
Q
E
T
V
Q
E
L
A
L
K
A
Y
K
V
L
G
V
R
G
M
A
R
V
D
F
F
L
A
E
-
G
E
L
Y
L
N
E
L
N
T
I
P
G
F
T
P
T
S
M
Y
P
R
L
F
E
A
G
G
V
A
Y
P
E
L
L
R
R
L
V
E
L
A
------------
32
PsiBlast_CBE
70.18
41%
-42
- C1 -
-
2ZDG
1
DDL_THET8
C:
[3-317]
----
V
L
L
I
A
G
G
V
S
P
E
H
E
V
S
L
L
S
A
E
G
V
L
---
R
H
I
P
-----
F
P
T
--
D
L
--
A
V
I
A
Q
D
G
R
W
L
L
G
E
K
A
--------
L
-------------
T
-------------
A
----------
L
----
E
--
A
K
A
---------------
A
P
-------
E
G
--
E
---
H
P
-----
F
P
P
-
P
L
S
W
E
R
Y
D
------
V
--
V
F
P
L
L
H
G
R
F
G
E
D
G
T
V
Q
G
F
L
E
L
L
G
K
P
Y
V
G
A
G
V
A
A
S
A
L
C
M
D
K
D
L
S
K
R
V
L
A
Q
A
-
G
-
V
P
V
V
P
W
V
A
V
-------
R
----
K
G
E
P
P
V
---
V
----
P
F
D
P
-
P
F
---
F
-------
V
K
P
A
N
T
G
S
S
V
G
I
S
R
V
E
R
F
Q
D
L
E
A
A
L
A
L
A
F
R
Y
D
E
K
A
V
V
E
K
A
L
-
S
-
P
V
R
E
L
E
V
G
V
L
G
N
V
--
F
G
------
E
A
S
P
V
G
E
V
R
-----
Y
E
-----
A
P
F
Y
D
Y
E
T
K
Y
T
--
P
G
-
R
--
A
---------
E
L
L
I
P
A
P
L
D
P
G
T
Q
E
T
V
Q
E
L
A
L
K
A
Y
K
V
L
G
V
R
G
M
A
R
V
D
F
F
L
A
E
-
G
E
L
Y
L
N
E
L
N
T
I
P
G
F
T
P
T
S
M
Y
P
R
L
F
E
A
G
G
V
A
Y
P
E
L
L
R
R
L
V
E
L
A
------------
97
HHSearch
69.90
38%
-23
- C1 -
-
3RFC
1
?
A:
[19-376]
R
K
I
R
V
G
L
I
F
G
G
K
S
A
E
H
E
V
S
L
Q
S
A
R
N
I
L
---
D
A
L
D
-
P
-
Q
R
F
E
P
--
V
L
--
I
G
I
D
K
Q
G
Q
W
H
V
N
D
P
D
--------
S
-------------
F
-------------
L
--
L
H
-
A
D
D
P
A
R
----
I
--
A
L
H
---------------
R
S
GR
G
V
A
L
L
P
G
AQ
Q
QQL
R
P
-----
I
Q
---
Q
A
L
A
Q
I
D
------
V
--
V
F
P
I
V
H
G
T
L
G
E
D
G
S
L
Q
G
L
L
R
M
A
N
L
P
F
V
G
S
G
V
L
G
S
A
V
A
M
D
K
D
M
A
K
R
V
L
R
D
A
-
R
-
L
A
V
A
P
F
V
C
F
-------
D
----
R
H
T
A
A
H
---
A
----
D
V
D
T
-
L
I
---
A
Q
L
G
L
P
L
F
V
K
P
A
N
Q
G
S
S
V
G
V
S
Q
V
R
T
A
D
A
F
A
A
A
L
A
L
A
L
A
Y
D
H
K
V
L
V
E
A
A
V
-
A
-
G
-
R
E
I
E
C
A
V
L
G
N
A
--
V
P
------
H
A
S
V
C
G
E
V
V
-----
V
-----------------------------------
E
I
V
I
P
A
D
I
D
A
Q
T
Q
Q
R
I
Q
Q
I
A
V
Q
A
Y
Q
A
L
G
C
A
G
M
A
R
V
D
V
F
L
C
A
D
G
R
I
V
I
N
E
V
N
T
L
P
G
F
T
R
I
S
V
Y
P
K
L
W
Q
A
S
G
L
D
Y
R
G
L
I
T
R
L
I
E
L
A
L
E
R
H
T
D
D
Q
L
---
8
PsiBlast_PDB
69.85
41%
-55
- C1 -
-
2YZN
1
DDL_THET8
A:
[3-317]
----
V
L
L
I
A
G
G
V
S
P
E
H
E
V
S
L
L
S
A
E
G
V
L
---
R
H
I
P
-----
F
P
T
--
D
L
--
A
V
I
A
Q
D
G
R
W
L
L
G
E
K
A
--------
L
-------------
T
-------------
A
----------
L
----
E
--
A
K
A
---------------
A
P
-------
E
G
--
E
---
H
P
-----
F
P
P
-
P
L
S
W
E
R
Y
D
------
V
--
V
F
P
L
L
H
G
R
F
G
E
D
G
T
V
Q
G
F
L
E
L
L
G
K
P
Y
V
G
A
G
V
A
A
S
A
L
C
M
D
K
D
L
S
K
R
V
L
A
Q
A
-
G
-
V
P
V
V
P
W
V
A
V
-------
R
----
K
G
E
P
P
V
---
V
----
P
F
D
P
-
P
F
---
F
-------
V
K
P
A
N
T
--
S
V
G
I
S
R
V
E
R
F
Q
D
L
E
A
A
L
A
L
A
F
R
Y
D
E
K
A
V
V
E
K
A
L
-
S
-
P
V
R
E
L
E
V
G
V
L
G
N
V
--
F
G
------
E
A
S
P
V
G
E
V
R
-----
Y
E
-----
A
P
F
Y
D
Y
E
T
K
Y
T
--
P
G
-
R
--
A
---------
E
L
L
I
P
A
P
L
D
P
G
T
Q
E
T
V
Q
E
L
A
L
K
A
Y
K
V
L
G
V
R
G
M
A
R
V
D
F
F
L
A
E
-
G
E
L
Y
L
N
E
L
N
T
I
P
G
F
T
P
T
S
M
Y
P
R
L
F
E
A
G
G
V
A
Y
P
E
L
L
R
R
L
V
E
L
A
------------
29
PsiBlast_CBE
69.41
41%
-50
- C1 -
-
2ZDH
2
DDL_THET8
C:
[3-317]
----
V
L
L
I
A
G
G
V
S
P
E
H
E
V
S
L
L
S
A
E
G
V
L
---
R
H
I
P
-----
F
P
T
--
D
L
--
A
V
I
A
Q
D
G
R
W
L
L
G
E
K
A
--------
L
-------------
T
-------------
A
----------
L
----
E
--
A
K
A
---------------
A
P
-------
E
G
--
E
---
H
P
-----
F
P
P
-
P
L
S
W
E
R
Y
D
------
V
--
V
F
P
L
L
H
G
R
F
G
E
D
G
T
V
Q
G
F
L
E
L
L
G
K
P
Y
V
G
A
G
V
A
A
S
A
L
C
M
D
K
D
L
S
K
R
V
L
A
Q
A
-
G
-
V
P
V
V
P
W
V
A
V
-------
R
----
K
G
E
P
P
V
---
V
----
P
F
D
P
-
P
F
---
F
-------
V
K
P
A
N
T
G
S
S
V
G
I
S
R
V
E
R
F
Q
D
L
E
A
A
L
A
L
A
F
R
Y
D
E
K
A
V
V
E
K
A
L
-
S
-
P
V
R
E
L
E
V
G
V
L
G
N
V
--
F
G
------
E
A
S
P
V
G
E
V
R
-----
Y
E
-----
A
P
F
Y
---
T
K
Y
T
--
P
G
-
R
--
A
---------
E
L
L
I
P
A
P
L
D
P
G
T
Q
E
T
V
Q
E
L
A
L
K
A
Y
K
V
L
G
V
R
G
M
A
R
V
D
F
F
L
A
E
-
G
E
L
Y
L
N
E
L
N
T
I
P
G
F
T
P
T
S
M
Y
P
R
L
F
E
A
G
G
V
A
Y
P
E
L
L
R
R
L
V
E
L
A
------------
36
PsiBlast_CBE
69.37
41%
-49
- C1 -
-
2YZM
1
DDL_THET8
C:
[3-317]
----
V
L
L
I
A
G
G
V
S
P
E
H
E
V
S
L
L
S
A
E
G
V
L
---
R
H
I
P
-----
F
P
T
--
D
L
--
A
V
I
A
Q
D
G
R
W
L
L
G
E
K
A
--------
L
-------------
T
-------------
A
----------
L
----
E
--
A
K
A
---------------
A
P
-------
E
G
--
E
---
H
P
-----
F
P
P
-
P
L
S
W
E
R
Y
D
------
V
--
V
F
P
L
L
H
G
R
F
G
E
D
G
T
V
Q
G
F
L
E
L
L
G
K
P
Y
V
G
A
G
V
A
A
S
A
L
C
M
D
K
D
L
S
K
R
V
L
A
Q
A
-
G
-
V
P
V
V
P
W
V
A
V
-------
R
----
K
G
E
P
P
V
---
V
----
P
F
D
P
-
P
F
---
F
-------
V
K
P
A
N
T
G
S
S
V
G
I
S
R
V
E
R
F
Q
D
L
E
A
A
L
A
L
A
F
R
Y
D
E
K
A
V
V
E
K
A
L
-
S
-
P
V
R
E
L
E
V
G
V
L
G
N
V
--
F
G
------
E
A
S
P
V
G
E
V
R
-----
Y
E
-----
A
P
--------------
R
--
A
---------
E
L
L
I
P
A
P
L
D
P
G
T
Q
E
T
V
Q
E
L
A
L
K
A
Y
K
V
L
G
V
R
G
M
A
R
V
D
F
F
L
A
E
-
G
E
L
Y
L
N
E
L
N
T
I
P
G
F
T
P
T
S
M
Y
P
R
L
F
E
A
G
G
V
A
Y
P
E
L
L
R
R
L
V
E
L
A
------------
34
PsiBlast_CBE
69.17
41%
-50
- C1 -
-
2YZN
1
DDL_THET8
C:
[3-317]
----
V
L
L
I
A
G
G
V
S
P
E
H
E
V
S
L
L
S
A
E
G
V
L
---
R
H
I
P
-----
F
P
T
--
D
L
--
A
V
I
A
Q
D
G
R
W
L
L
G
E
K
A
--------
L
-------------
T
-------------
A
----------
L
----
E
--
A
K
A
---------------
A
P
-------
E
G
--
E
---
H
P
-----
F
P
P
-
P
L
S
W
E
R
Y
D
------
V
--
V
F
P
L
L
H
G
R
F
G
E
D
G
T
V
Q
G
F
L
E
L
L
G
K
P
Y
V
G
A
G
V
A
A
S
A
L
C
M
D
K
D
L
S
K
R
V
L
A
Q
A
-
G
-
V
P
V
V
P
W
V
A
V
-------
R
----
K
G
E
P
P
V
---
V
----
P
F
D
P
-
P
F
---
F
-------
V
K
P
A
N
T
G
S
S
V
G
I
S
R
V
E
R
F
Q
D
L
E
A
A
L
A
L
A
F
R
Y
D
E
K
A
V
V
E
K
A
L
-
S
-
P
V
R
E
L
E
V
G
V
L
G
N
V
--
F
G
------
E
A
S
P
V
G
E
V
R
-----
Y
E
-----
A
------------
P
G
-
R
--
A
---------
E
L
L
I
P
A
P
L
D
P
G
T
Q
E
T
V
Q
E
L
A
L
K
A
Y
K
V
L
G
V
R
G
M
A
R
V
D
F
F
L
A
E
-
G
E
L
Y
L
N
E
L
N
T
I
P
G
F
T
P
T
S
M
Y
P
R
L
F
E
A
G
G
V
A
Y
P
E
L
L
R
R
L
V
E
L
A
------------
104
HHSearch
69.02
42%
-60
- C1 -
-
2ZDG
1
DDL_THET8
C:
[1-318]
--
M
R
V
L
L
I
A
G
G
V
S
P
E
H
E
V
S
L
L
S
A
E
G
V
L
---
R
H
I
P
---
F
P
T
D
L
--
A
V
--
I
A
Q
D
G
R
--
W
L
L
G
E
K
A
--------
L
-------------
T
-------------
A
--
L
E
-
A
K
-
A
A
P
----
E
--
G
E
H
---------------
P
F
---------------
P
P
---------
P
L
S
W
E
R
Y
D
------
V
--
V
F
P
L
L
H
G
R
F
G
E
D
G
T
V
Q
G
F
L
E
L
L
G
K
P
Y
V
G
A
G
V
A
A
S
A
L
C
M
D
K
D
L
S
K
R
V
L
A
Q
A
-
G
-
V
P
V
V
P
W
V
A
V
-------
R
----
K
G
E
P
P
---------------
V
---
V
P
F
D
P
P
F
F
V
K
P
A
N
T
G
S
S
V
G
I
S
R
V
E
R
F
Q
D
L
E
A
A
L
A
L
A
F
R
Y
D
E
K
A
V
V
E
K
A
L
-
S
P
V
-
R
E
L
E
V
G
V
L
G
N
V
F
G
E
A
------
S
P
V
G
E
V
R
Y
E
------------
A
P
F
Y
D
Y
E
T
K
Y
T
--
P
G
-
R
--
A
---------
E
L
L
I
P
A
P
L
D
P
G
T
Q
E
T
V
Q
E
L
A
L
K
A
Y
K
V
L
G
V
R
G
M
A
R
V
D
F
F
L
A
-
E
G
E
L
Y
L
N
E
L
N
T
I
P
G
F
T
P
T
S
M
Y
P
R
L
F
E
A
G
G
V
A
Y
P
E
L
L
R
R
L
V
E
L
A
L
-----------
15
PsiBlast_PDB
67.78
39%
-29
- C1 -
-
3R5F
1
?
A:
[25-369]
------
L
I
F
G
G
K
S
A
E
H
E
V
S
L
Q
S
A
R
N
I
L
---
D
A
L
D
-
P
-
Q
R
F
E
P
--
V
L
--
I
G
I
D
K
Q
G
Q
W
H
V
N
D
P
D
--------
S
FLLHADDPA
R
I
A
L
H
-------------
R
--
S
G
-
R
G
-
V
A
L
----
L
--
P
G
A
---------------
Q
Q
-------
Q
Q
--
L
---
R
P
-----
I
Q
----
A
L
A
Q
I
D
------
V
--
V
F
P
I
V
H
G
T
L
G
E
D
G
S
L
Q
G
L
L
R
M
A
N
L
P
F
V
G
S
G
V
L
G
S
A
V
A
M
D
K
D
M
A
K
R
V
L
R
D
A
-
R
-
L
A
V
A
P
F
V
C
F
--------------
D
R
H
T
---
A
----
A
H
A
D
-
V
D
T
L
I
A
Q
L
G
L
P
L
F
V
K
P
A
N
Q
G
S
S
V
G
V
S
Q
V
R
T
A
D
A
F
A
A
A
L
A
L
A
L
A
Y
D
H
K
V
L
V
E
A
A
V
-
A
-
G
-
R
E
I
E
C
A
V
L
G
N
A
--
V
P
------
H
A
S
V
C
G
E
V
V
-----
V
-----------------------------------
E
I
V
I
P
A
D
I
D
A
Q
T
Q
Q
R
I
Q
Q
I
A
V
Q
A
Y
Q
A
L
G
C
A
G
M
A
R
V
D
V
F
L
C
A
D
G
R
I
V
I
N
E
V
N
T
L
P
G
F
T
R
I
S
V
Y
P
K
L
W
Q
A
S
G
L
D
Y
R
G
L
I
T
R
L
I
E
L
A
L
E
----------
103
HHSearch
67.47
42%
-66
- C1 -
-
2ZDH
2
DDL_THET8
C:
[1-318]
--
M
R
V
L
L
I
A
G
G
V
S
P
E
H
E
V
S
L
L
S
A
E
G
V
L
---
R
H
I
P
---
F
P
T
D
L
--
A
V
--
I
A
Q
D
G
R
--
W
L
L
G
E
K
A
--------
L
-------------
T
-------------
A
--
L
E
-
A
K
-
A
A
P
----
E
--
G
E
H
---------------
P
F
---------------
P
P
---------
P
L
S
W
E
R
Y
D
------
V
--
V
F
P
L
L
H
G
R
F
G
E
D
G
T
V
Q
G
F
L
E
L
L
G
K
P
Y
V
G
A
G
V
A
A
S
A
L
C
M
D
K
D
L
S
K
R
V
L
A
Q
A
-
G
-
V
P
V
V
P
W
V
A
V
-------
R
----
K
G
E
P
P
---------------
V
---
V
P
F
D
P
P
F
F
V
K
P
A
N
T
G
S
S
V
G
I
S
R
V
E
R
F
Q
D
L
E
A
A
L
A
L
A
F
R
Y
D
E
K
A
V
V
E
K
A
L
-
S
P
V
-
R
E
L
E
V
G
V
L
G
N
V
F
G
E
A
------
S
P
V
G
E
V
R
Y
E
------------
A
P
F
Y
---
T
K
Y
T
--
P
G
-
R
--
A
---------
E
L
L
I
P
A
P
L
D
P
G
T
Q
E
T
V
Q
E
L
A
L
K
A
Y
K
V
L
G
V
R
G
M
A
R
V
D
F
F
L
A
-
E
G
E
L
Y
L
N
E
L
N
T
I
P
G
F
T
P
T
S
M
Y
P
R
L
F
E
A
G
G
V
A
Y
P
E
L
L
R
R
L
V
E
L
A
L
-----------
33
PsiBlast_CBE
67.11
41%
-52
- C1 -
-
2ZDG
1
DDL_THET8
B:
[3-317]
----
V
L
L
I
A
G
G
V
S
P
E
H
E
V
S
L
L
S
A
E
G
V
L
---
R
H
I
P
-----
F
P
T
--
D
L
--
A
V
I
A
Q
D
G
R
W
L
L
G
E
K
A
--------
L
-------------
T
-------------
A
----------
L
----
E
--
A
K
A
---------------
A
P
-------
E
G
--
E
---
H
P
-----
F
P
P
-
P
L
S
W
E
R
Y
D
------
V
--
V
F
P
L
L
H
G
R
F
G
E
D
G
T
V
Q
G
F
L
E
L
L
G
K
P
Y
V
G
A
G
V
A
A
S
A
L
C
M
D
K
D
L
S
K
R
V
L
A
Q
A
-
G
-
V
P
V
V
P
W
V
A
V
-------
R
----
K
G
E
P
P
V
---
V
----
P
F
D
P
-
P
F
---
F
-------
V
K
P
A
N
T
G
S
S
V
G
I
S
R
V
E
R
F
Q
D
L
E
A
A
L
A
L
A
F
R
Y
D
E
K
A
V
V
E
K
A
L
-
S
-
P
V
R
E
L
E
V
G
V
L
G
N
V
--
F
G
------
E
A
S
P
V
G
E
V
R
-----
Y
E
-----
A
----------------------------
E
L
L
I
P
A
P
L
D
--
T
Q
E
T
V
Q
E
L
A
L
K
A
Y
K
V
L
G
V
R
G
M
A
R
V
D
F
F
L
A
E
-
G
E
L
Y
L
N
E
L
N
T
I
P
G
F
T
P
T
S
M
Y
P
R
L
F
E
A
G
G
V
A
Y
P
E
L
L
R
R
L
V
E
L
A
------------
37
PsiBlast_CBE
66.92
41%
-53
- C1 -
-
2YZM
1
DDL_THET8
B:
[3-317]
----
V
L
L
I
A
G
G
V
S
P
E
H
E
V
S
L
L
S
A
E
G
V
L
---
R
H
I
P
-----
F
P
T
--
D
L
--
A
V
I
A
Q
D
G
R
W
L
L
G
E
K
A
--------
L
-------------
T
-------------
A
----------
L
----
E
--
A
K
A
---------------
A
P
-------
E
G
--
E
---
H
P
-----
F
P
P
-
P
L
S
W
E
R
Y
D
------
V
--
V
F
P
L
L
H
G
R
F
G
E
D
G
T
V
Q
G
F
L
E
L
L
G
K
P
Y
V
G
A
G
V
A
A
S
A
L
C
M
D
K
D
L
S
K
R
V
L
A
Q
A
-
G
-
V
P
V
V
P
W
V
A
V
-------
R
----
K
G
E
P
P
V
---
V
----
P
F
D
P
-
P
F
---
F
-------
V
K
P
A
N
T
G
S
S
V
G
I
S
R
V
E
R
F
Q
D
L
E
A
A
L
A
L
A
F
R
Y
D
E
K
A
V
V
E
K
A
L
-
S
-
P
V
R
E
L
E
V
G
V
L
G
N
V
--
F
G
------
E
A
S
P
V
G
E
V
R
-----
Y
E
-----
A
P
F
-------
T
--
P
G
-
R
--
A
---------
E
L
L
I
P
A
P
L
D
P
G
T
Q
E
T
V
Q
E
L
A
L
K
A
Y
K
V
L
G
V
R
G
M
A
R
V
D
F
F
L
A
E
-
G
E
L
Y
L
N
E
L
N
T
I
P
G
F
T
P
T
S
M
Y
P
R
L
F
E
A
G
G
V
A
Y
P
E
L
L
R
R
L
V
E
L
A
------------
14
PsiBlast_PDB
66.33
39%
-28
- C1 -
-
3RFC
1
?
A:
[25-369]
------
L
I
F
G
G
K
S
A
E
H
E
V
S
L
Q
S
A
R
N
I
L
---
D
A
L
D
-
P
-
Q
R
F
E
P
--
V
L
--
I
G
I
D
K
Q
G
Q
W
H
V
N
D
P
D
--------
S
FLLHADDPA
R
I
A
L
H
-------------
R
--
S
G
-
R
G
-
V
A
L
----
L
--
P
G
A
---------------
Q
Q
-------
Q
Q
--
L
---
R
P
-----
I
Q
---
Q
A
L
A
Q
I
D
------
V
--
V
F
P
I
V
H
G
T
L
G
E
D
G
S
L
Q
G
L
L
R
M
A
N
L
P
F
V
G
S
G
V
L
G
S
A
V
A
M
D
K
D
M
A
K
R
V
L
R
D
A
-
R
-
L
A
V
A
P
F
V
C
F
--------------
D
R
H
T
---
A
----
A
H
A
D
-
V
D
T
L
I
A
Q
L
G
L
P
L
F
V
K
P
A
N
Q
G
S
S
V
G
V
S
Q
V
R
T
A
D
A
F
A
A
A
L
A
L
A
L
A
Y
D
H
K
V
L
V
E
A
A
V
-
A
-
G
-
R
E
I
E
C
A
V
L
G
N
A
--
V
P
------
H
A
S
V
C
G
E
V
V
-----
V
-----------------------------------
E
I
V
I
P
A
D
I
D
A
Q
T
Q
Q
R
I
Q
Q
I
A
V
Q
A
Y
Q
A
L
G
C
A
G
M
A
R
V
D
V
F
L
C
A
D
G
R
I
V
I
N
E
V
N
T
L
P
G
F
T
R
I
S
V
Y
P
K
L
W
Q
A
S
G
L
D
Y
R
G
L
I
T
R
L
I
E
L
A
L
E
----------
16
PsiBlast_PDB
66.20
39%
-26
- C1 -
-
4L1K
1
?
A:
[25-369]
------
L
I
F
G
G
K
S
A
E
H
E
V
S
L
Q
S
A
R
N
I
L
---
D
A
L
D
-
P
-
Q
R
F
E
P
--
V
L
--
I
G
I
D
K
Q
G
Q
W
H
V
N
D
P
D
--------
S
FLLHADDPA
R
I
A
L
H
-------------
R
--
S
G
-
R
G
-
V
A
L
----
L
--
P
G
A
---------------
Q
Q
-------
Q
Q
--
L
---
R
P
-----
I
Q
---
Q
A
L
A
Q
I
D
------
V
--
V
F
P
I
V
H
G
T
L
G
E
D
G
S
L
Q
G
L
L
R
M
A
N
L
P
F
V
G
S
G
V
L
G
S
A
V
A
M
D
K
D
M
A
K
R
V
L
R
D
A
-
R
-
L
A
V
A
P
F
V
C
F
--------------
D
R
H
T
---
A
----
A
H
A
D
-
V
D
T
L
I
A
Q
L
G
L
P
L
F
V
K
P
A
N
Q
G
S
S
V
G
V
S
Q
V
R
T
A
D
A
F
A
A
A
L
A
L
A
L
A
Y
D
H
K
V
L
V
E
A
A
V
-
A
-
G
-
R
E
I
E
C
A
V
L
G
N
A
--
V
P
------
H
A
S
V
C
G
E
V
V
-----
V
-----------------------------------
E
I
V
I
P
A
D
I
D
A
Q
T
Q
Q
R
I
Q
Q
I
A
V
Q
A
Y
Q
A
L
G
C
A
G
M
A
R
V
D
V
F
L
C
A
D
G
R
I
V
I
N
E
V
N
T
L
P
G
F
T
R
I
S
V
Y
P
K
L
W
Q
A
S
G
L
D
Y
R
G
L
I
T
R
L
I
E
L
A
L
E
----------
35
PsiBlast_CBE
66.08
41%
-49
- C1 -
-
2YZN
1
DDL_THET8
B:
[3-317]
----
V
L
L
I
A
G
G
V
S
P
E
H
E
V
S
L
L
S
A
E
G
V
L
---
R
H
I
P
-----
F
P
T
--
D
L
--
A
V
I
A
Q
D
G
R
W
L
L
G
E
K
A
--------
L
-------------
T
-------------
A
----------
L
----
E
--
A
K
A
---------------
A
P
-------
E
G
--
E
---
H
P
-----
F
P
P
-
P
L
S
W
E
R
Y
D
------
V
--
V
F
P
L
L
H
G
R
F
G
E
D
G
T
V
Q
G
F
L
E
L
L
G
K
P
Y
V
G
A
G
V
A
A
S
A
L
C
M
D
K
D
L
S
K
R
V
L
A
Q
A
-
G
-
V
P
V
V
P
W
V
A
V
-------
R
----
K
G
E
P
P
V
---
V
----
P
F
D
P
-
P
F
---
F
-------
V
K
P
A
N
T
G
S
S
V
G
I
S
R
V
E
R
F
Q
D
L
E
A
A
L
A
L
A
F
R
Y
D
E
K
A
V
V
E
K
A
L
-
S
-
P
V
R
E
L
E
V
G
V
L
G
N
V
--
F
G
------
E
A
S
P
V
G
E
V
R
-----
Y
E
-----
A
P
F
Y
------
T
--
P
G
-
R
--
A
---------
E
L
L
I
P
A
P
L
D
P
G
T
Q
E
T
V
Q
E
L
A
L
K
A
Y
K
V
L
G
V
R
G
M
A
R
V
D
F
F
L
A
E
-
G
E
L
Y
L
N
E
L
N
T
I
P
G
F
T
P
T
S
M
Y
P
R
L
F
E
A
G
G
V
A
Y
P
E
L
L
R
R
L
V
E
L
A
------------
18
PsiBlast_PDB
65.12
39%
-25
- C1 -
-
4ME6
1
?
A:
[27-371]
------
L
I
F
G
G
K
S
A
E
H
E
V
S
L
Q
S
A
R
N
I
L
---
D
A
L
D
-
P
-
Q
R
F
E
P
--
V
L
--
I
G
I
D
K
Q
G
Q
W
H
V
N
D
P
D
--------
S
FLLHADDPA
R
I
A
L
H
-------------
R
--
S
G
-
R
G
-
V
A
L
----
L
--
P
G
A
---------------
Q
Q
-------
Q
Q
--
L
---
R
P
-----
I
Q
------
A
Q
I
D
------
V
--
V
F
P
I
V
H
G
T
L
G
E
D
G
S
L
Q
G
L
L
R
M
A
N
L
P
F
V
G
S
G
V
L
G
S
A
V
A
M
D
K
D
M
A
K
R
V
L
R
D
A
-
R
-
L
A
V
A
P
F
V
C
F
--------------
D
R
H
T
--------
A
H
A
D
-
V
D
T
L
I
A
Q
L
G
L
P
L
F
V
K
P
A
N
Q
---
V
G
V
S
Q
V
R
T
A
D
A
F
A
A
A
L
A
L
A
L
A
Y
D
H
K
V
L
V
E
A
A
V
-
A
-
G
-
R
E
I
E
C
A
V
L
G
N
A
--
V
P
------
H
A
S
V
C
G
E
V
V
-----------------------------------------
E
I
V
I
P
A
D
I
D
A
Q
T
Q
Q
R
I
Q
Q
I
A
V
Q
A
Y
Q
A
L
G
C
A
G
M
A
R
V
D
V
F
L
C
A
D
G
R
I
V
I
N
E
V
N
T
L
P
G
F
T
R
I
S
V
Y
P
K
L
W
Q
A
S
G
L
D
Y
R
G
L
I
T
R
L
I
E
L
A
L
E
----------
31
PsiBlast_CBE
63.50
41%
-48
- C1 -
-
2ZDG
1
DDL_THET8
D:
[3-317]
----
V
L
L
I
A
G
G
V
S
P
E
H
E
V
S
L
L
S
A
E
G
V
L
---
R
H
I
P
-----
F
P
T
--
D
L
--
A
V
I
A
Q
D
G
R
W
L
L
G
E
K
A
--------
L
-------------
T
-------------
A
----------
L
----
E
--
A
K
A
---------------
A
P
-------
E
G
--
E
---
H
P
-----
F
P
P
-
P
L
S
W
E
R
Y
D
------
V
--
V
F
P
L
L
H
G
R
F
G
E
D
G
T
V
Q
G
F
L
E
L
L
G
K
P
Y
V
G
A
G
V
A
A
S
A
L
C
M
D
K
D
L
S
K
R
V
L
A
Q
A
-
G
-
V
P
V
V
P
W
V
A
V
-------
R
----
K
G
E
P
P
V
---
V
----
P
F
D
P
-
P
F
---
F
-------
V
K
P
A
N
T
G
S
S
V
G
I
S
R
V
E
R
F
Q
D
L
E
A
A
L
A
L
A
F
R
Y
D
E
K
A
V
V
E
K
A
L
-
S
-
P
V
R
E
L
E
V
G
V
L
G
N
V
--
F
G
------
E
A
S
P
V
G
E
V
R
-----
Y
E
-----
A
P
-----------------
A
---------
E
L
L
I
P
A
P
L
---
T
Q
E
T
V
Q
E
L
A
L
K
A
Y
K
V
L
G
V
R
G
M
A
R
V
D
F
F
L
A
E
-
G
E
L
Y
L
N
E
L
N
T
I
P
G
F
T
P
T
S
M
Y
P
R
L
F
E
A
G
G
V
A
Y
P
E
L
L
R
R
L
V
E
L
A
------------
45
PsiBlast_CBE
62.33
33%
30
- C1 -
-
1EHI
2
DDL_LEUMM
A:
[3-355]
-
K
K
R
V
A
L
I
F
G
G
N
S
S
E
H
D
V
S
K
R
S
A
Q
N
F
Y
---
N
A
I
E
A
T
-
G
K
Y
E
I
--
I
V
--
F
A
I
A
Q
N
G
F
F
L
D
T
E
S
S
--------
K
-------------
K
-------------
I
--
L
A
-
L
E
-
D
E
Q
P
I
V
D
A
--
F
M
K
---------------
T
V
-------
D
A
--
S
---
D
P
-----
L
A
R
I
H
A
L
K
S
A
G
D
FD----
I
--
F
F
P
V
V
H
G
N
L
G
E
D
G
T
L
Q
G
L
F
K
L
L
D
K
P
Y
V
G
A
P
L
R
G
H
A
V
S
F
D
K
A
L
T
K
E
L
L
T
V
N
-
G
-
I
R
N
T
K
Y
I
V
V
-------
D
----
P
E
S
A
N
N
---
W
----
S
W
D
K
-
I
V
---
A
E
L
G
N
I
V
F
V
K
A
A
N
Q
G
S
S
V
G
I
S
R
V
T
N
A
E
E
Y
T
E
A
L
S
D
S
F
Q
Y
D
Y
K
V
L
I
E
E
A
V
-
N
G
A
-
R
E
L
E
V
G
V
I
G
N
D
--
Q
P
L
V
S
E
I
G
A
H
T
V
P
N
Q
G
S
-----
G
D
------
G
W
Y
D
Y
N
N
K
F
V
--
D
N
-
S
A-
V
---------
H
F
Q
I
P
A
Q
L
S
P
E
V
T
K
E
V
K
Q
M
A
L
D
A
Y
K
V
L
N
L
R
G
E
A
R
M
D
F
L
L
D
E
N
N
V
P
Y
L
G
E
P
N
T
L
P
G
F
T
N
M
S
L
F
K
R
L
W
D
Y
S
D
I
N
N
A
K
L
V
D
M
L
I
D
Y
G
F
E
D
F
--------
46
PsiBlast_CBE
62.30
35%
-13
- C1 -
-
1E4E
8
VANA_ENTFC
B:
[6-340]
----
V
A
I
L
F
G
G
C
S
E
E
H
D
V
S
V
K
S
A
I
E
I
A
---
A
N
I
N
-
K
-
E
K
Y
E
P
--
L
Y
--
I
G
I
T
K
S
G
V
W
-
K
M
C
E
K
--------
P
-------------
C
-------------
A
--
E
W
-
E
N
-
E
N
C
----
Y
--
S
-
A
---------------
V
L
-------
S
P
--
D
---
K
K
MHGLL
V
K
K
-
N
H
E
Y
E
I
N
H
------
V
DV
A
F
S
A
L
H
G
K
S
G
E
D
G
S
I
Q
G
L
F
E
L
S
G
I
P
F
V
G
C
D
I
Q
S
S
A
I
C
M
D
K
S
L
T
Y
I
V
A
K
N
A
-
G
-
I
A
-
T
P
A
F
W
V
-------
I
----
N
K
D
D
------------
R
P
-
V
A
---
A
T
F
T
Y
P
V
F
V
K
P
A
R
S
G
S
S
F
G
V
K
K
V
N
S
A
D
E
L
D
Y
A
I
E
S
A
R
Q
Y
D
S
K
I
L
I
E
Q
A
V
-
S
-
G
-
C
E
V
G
C
A
V
L
G
N
S
----------
A
A
L
V
V
G
E
V
-------
D
-----
Q
I
R
L
Q
Y
G
I
F
R
I
--
H
Q
-
E
--
V
EPEKGSENA
V
I
T
V
P
A
D
L
S
A
E
E
R
G
R
I
Q
E
T
V
K
K
I
Y
K
T
L
G
C
R
G
L
A
R
V
D
M
F
L
Q
D
R
G
R
I
V
L
N
E
V
N
T
L
P
G
F
T
S
Y
S
R
Y
P
R
M
M
A
A
A
G
I
S
L
P
E
L
I
D
R
L
I
V
L
A
------------
91
HHSearch
62.22
33%
25
- C1 -
-
1EHI
2
DDL_LEUMM
A:
[3-357]
-
K
K
R
V
A
L
I
F
G
G
N
S
S
E
H
D
V
S
K
R
S
A
Q
N
F
Y
---
N
A
I
E
A
T
-
G
K
Y
E
I
--
I
V
--
F
A
I
A
Q
N
G
F
F
L
D
T
E
S
S
--------
K
-------------
K
I
L
A
LEDE
Q
P
I
V
D
A
F
--
M
K
-
T
V
-
D
A
S
----
D
--
P
L
A
---------------
R
I
---------------
H
A
---------
L
K
S
A
G
D
F
D
------
I
--
F
F
P
V
V
H
G
N
L
G
E
D
G
T
L
Q
G
L
F
K
L
L
D
K
P
Y
V
G
A
P
L
R
G
H
A
V
S
F
D
K
A
L
T
K
E
L
L
T
V
N
-
G
-
I
R
N
T
K
Y
I
V
V
-------
D
----
P
E
S
A
N
N
---
W
----
S
W
D
K
-
I
V
---
A
E
L
G
N
I
V
F
V
K
A
A
N
Q
G
S
S
V
G
I
S
R
V
T
N
A
E
E
Y
T
E
A
L
S
D
S
F
Q
Y
D
Y
K
V
L
I
E
E
A
V
-
N
-
G
A
R
E
L
E
V
G
V
I
G
N
D
--
Q
P
------
L
V
S
E
I
G
A
H
T
-----
V
P
NQGSG
D
G
W
Y
D
Y
N
N
K
F
V
--
D
N
-
S
A-
V
---------
H
F
Q
I
P
A
Q
L
S
P
E
V
T
K
E
V
K
Q
M
A
L
D
A
Y
K
V
L
N
L
R
G
E
A
R
M
D
F
L
L
D
E
N
N
V
P
Y
L
G
E
P
N
T
L
P
G
F
T
N
M
S
L
F
K
R
L
W
D
Y
S
D
I
N
N
A
K
L
V
D
M
L
I
D
Y
G
F
E
D
F
A
Q
------
50
PsiBlast_CBE
60.90
34%
-14
- C1 -
-
5C1P
4
DDL_YERPE
D:
[2-305]
-
A
E
K
V
A
V
L
L
G
G
T
S
A
E
R
E
V
S
L
L
S
G
Q
A
V
L
A
G
L
K
E
A
G
-
I
-
D
A
Y
G
V
--
D
T
KD
F
P
V
T
Q
----
L
K
E
Q
G
F
--------------------------------------------------------------------------------------
D
---
K
---------------------------
V
F
I
A
L
H
G
R
G
G
E
D
G
T
L
Q
G
V
L
E
F
L
Q
L
P
Y
T
G
S
G
V
M
A
S
A
L
T
M
D
K
L
R
T
K
L
V
W
Q
A
L
-
G
-
L
P
I
S
P
Y
V
A
L
N
R
Q
Q
F
E
T
L
----
S
P
E
E
L
V
---
A
----
C
V
A
--------
K
L
G
L
P
L
I
V
K
P
S
H
E
---
V
G
M
S
K
V
D
H
A
S
E
L
Q
K
A
L
V
E
A
F
Q
H
D
S
D
V
L
I
E
K
W
L
-
S
-
G
-
P
E
F
T
V
A
I
L
G
D
E
--
V
L
------
P
S
I
---
R
I
Q
-----
P
P
-----
G
V
F
Y
D
Y
D
A
K
Y
L
--
S
D
-
K
--
T
---------
Q
Y
F
C
P
S
G
L
S
D
E
S
E
Q
Q
L
A
A
L
A
L
Q
A
Y
H
A
L
D
C
S
G
W
G
R
V
D
V
M
Q
D
R
D
G
H
F
Y
L
L
E
V
N
T
S
P
G
M
T
S
H
S
L
V
P
M
A
A
R
Q
Y
G
L
S
F
S
Q
L
V
A
R
I
L
M
L
A
------------
73
PsiBlast_CBE
59.55
31%
2
- C1 -
-
4C5C
5
DDLB_ECOLI
A:
[25-329]
M
T
D
K
I
A
V
L
L
G
G
T
S
A
E
R
E
V
S
L
N
S
G
A
A
V
L
A
G
L
R
E
G
G
-
I
-
D
A
Y
P
V
D
P
K
E
--
V
D
V
T
Q
----
L
K
S
M
G
F
--------
Q
-------------
K
-----------------------------------------------------------------------------------------------
V
F
I
A
L
H
G
R
G
G
E
D
G
T
L
Q
G
M
L
E
L
M
G
L
P
Y
T
G
S
G
V
M
A
S
A
L
S
M
D
K
L
R
S
K
L
L
W
Q
G
A
-
G
-
L
P
V
A
P
W
V
A
L
-------
T
----
R
A
E
F
E
K
---
G
LS
D
K
Q
L
A
E
-
I
----
S
A
L
G
L
P
V
I
V
K
P
S
R
E
G
S
S
V
G
M
S
K
V
V
A
E
N
A
L
Q
D
A
L
R
L
A
F
Q
H
D
E
E
V
L
I
E
K
W
L
-
S
-
G
-
P
E
F
T
V
A
I
L
G
E
E
--
I
L
------
P
S
I
---
R
I
Q
-----
P
S
-----
G
T
F
Y
D
Y
E
A
K
Y
L
--
S
D
-
E
--
T
---------
Q
Y
F
C
P
A
G
L
E
A
S
Q
E
A
N
L
Q
A
L
V
L
K
A
W
T
T
L
G
C
K
G
W
G
R
I
D
V
M
L
D
S
D
G
Q
F
Y
L
L
E
A
N
T
S
P
G
M
T
S
H
S
L
V
P
M
A
A
R
Q
A
G
M
S
F
S
Q
L
V
V
R
I
L
E
L
A
------------
78
PsiBlast_CBE
59.10
31%
0
- C1 -
-
1IOW
2
DDLB_ECOLI
A:
[1-305]
M
T
D
K
I
A
V
L
L
G
G
T
S
A
E
R
E
V
S
L
N
S
G
A
A
V
L
A
G
L
R
E
G
G
-
I
-
D
A
Y
P
V
D
P
K
E
--
V
D
V
T
Q
----
L
K
S
M
G
F
--------
Q
-------------
K
-----------------------------------------------------------------------------------------------
V
F
I
A
L
H
G
R
G
G
E
D
G
T
L
Q
G
M
L
E
L
M
G
L
P
Y
T
G
S
G
V
M
A
S
A
L
S
M
D
K
L
R
S
K
L
L
W
Q
G
A
-
G
-
L
P
V
A
P
W
V
A
L
-------
T
----
R
A
E
F
E
K
---
G
LS
D
K
Q
L
A
E
-
I
----
S
A
L
G
L
P
V
I
V
K
P
S
R
E
G
S
S
V
G
M
S
K
V
V
A
E
N
A
L
Q
D
A
L
R
L
A
F
Q
H
D
E
E
V
L
I
E
K
W
L
-
S
-
G
-
P
E
F
T
V
A
I
L
G
E
E
--
I
L
------
P
S
I
---
R
I
Q
-----
P
S
-----
G
T
F
Y
D
Y
E
A
K
F
L
--
S
D
-
E
--
T
---------
Q
Y
F
C
P
A
G
L
E
A
S
Q
E
A
N
L
Q
A
L
V
L
K
A
W
T
T
L
G
C
K
G
W
G
R
I
D
V
M
L
D
S
D
G
Q
F
Y
L
L
E
A
N
T
S
P
G
M
T
S
H
S
L
V
P
M
A
A
R
Q
A
G
M
S
F
S
Q
L
V
V
R
I
L
E
L
A
------------
76
PsiBlast_CBE
59.04
31%
4
- C1 -
-
4C5A
2
DDLB_ECOLI
B:
[27-329]
--
D
K
I
A
V
L
L
G
G
T
S
A
E
R
E
V
S
L
N
S
G
A
A
V
L
A
G
L
R
E
G
G
-
I
-
D
A
Y
P
V
D
P
K
E
--
V
D
V
T
Q
----
L
K
S
M
G
F
--------
Q
-------------
K
-----------------------------------------------------------------------------------------------
V
F
I
A
L
H
G
R
G
G
E
D
G
T
L
Q
G
M
L
E
L
M
G
L
P
Y
T
G
S
G
V
M
A
S
A
L
S
M
D
K
L
R
S
K
L
L
W
Q
G
A
-
G
-
L
P
V
A
P
W
V
A
L
-------
T
----
R
A
E
F
E
K
---
G
LS
D
K
Q
L
A
E
-
I
----
S
A
L
G
L
P
V
I
V
K
P
S
R
E
G
S
S
V
G
M
S
K
V
V
A
E
N
A
L
Q
D
A
L
R
L
A
F
Q
H
D
E
E
V
L
I
E
K
W
L
-
S
-
G
-
P
E
F
T
V
A
I
L
G
E
E
--
I
L
------
P
S
I
---
R
I
Q
-----
P
S
-----
G
T
F
Y
D
Y
E
A
K
Y
L
--
S
D
-
E
--
T
---------
Q
Y
F
C
P
A
G
L
E
A
S
Q
E
A
N
L
Q
A
L
V
L
K
A
W
T
T
L
G
C
K
G
W
G
R
I
D
V
M
L
D
S
D
G
Q
F
Y
L
L
E
A
N
T
S
P
G
M
T
S
H
S
L
V
P
M
A
A
R
Q
A
G
M
S
F
S
Q
L
V
V
R
I
L
E
L
A
------------
47
PsiBlast_CBE
58.89
35%
-13
- C1 -
-
1E4E
8
VANA_ENTFC
A:
[6-340]
----
V
A
I
L
F
G
G
C
S
E
E
H
D
V
S
V
K
S
A
I
E
I
A
---
A
N
I
N
-
K
-
E
K
Y
E
P
--
L
Y
--
I
G
I
T
K
S
G
V
W
-
K
M
C
E
K
--------
P
-------------
C
-------------
A
--
E
W
-
E
N
-
E
N
C
----
Y
--
S
-
A
---------------
V
L
-------
S
P
--
D
---
K
K
MH
G
L
L
V
K
K
-
N
H
E
Y
E
I
N
H
------
V
D
V
A
F
S
A
L
H
G
K
S
G
E
D
G
S
I
Q
G
L
F
E
L
S
G
I
P
F
V
G
C
D
I
Q
S
S
A
I
C
M
D
K
S
L
T
Y
I
V
A
K
N
A
-
G
-
I
A
-
T
P
A
F
W
V
-------
I
----
N
K
D
D
------------
R
P
-
V
A
---
A
T
F
T
Y
P
V
F
V
K
P
A
R
S
G
S
S
F
G
V
K
K
V
N
S
A
D
E
L
D
Y
A
I
E
S
A
R
Q
Y
D
S
K
I
L
I
E
Q
A
V
-
S
-
G
-
C
E
V
G
C
A
V
L
G
N
S
----------
A
A
L
V
V
G
E
V
-------
D
-----
Q
I
R
L
Q
Y
G
I
F
R
I
--
H
Q
-
E
--
V
EPEKGSEN
A
V
I
T
V
P
A
D
L
S
A
E
E
R
G
R
I
Q
E
T
V
K
K
I
Y
K
T
L
G
C
R
G
L
A
R
V
D
M
F
L
Q
D
N
G
R
I
V
L
N
E
V
N
T
L
P
G
F
T
S
Y
S
R
Y
P
R
M
M
A
A
A
G
I
S
L
P
E
L
I
D
R
L
I
V
L
A
------------
80
PsiBlast_CBE
58.82
31%
-10
- C1 -
-
4EG0
2
DDL_BURA4
A:
[16-313]
----
V
A
V
L
F
G
G
E
S
A
E
R
E
V
S
L
T
S
G
R
L
V
L
---
Q
G
------------------
L
R
D
A
G
--
I
D
A
H
P
F
--------
D
-------------
P
-------------
A
--------
E
R
P
----
L
------------------------------------------------
S
A
L
K
D
E
G
F
------
V
R-
A
F
N
A
L
H
G
G
Y
G
E
N
G
Q
I
Q
G
A
L
D
F
Y
G
I
R
Y
T
G
S
G
V
L
G
S
A
L
G
L
D
K
F
R
T
K
L
V
W
Q
Q
T
-
G
-
V
P
T
P
P
F
E
T
V
-------
M
----
R
G
D
D
Y
A
---
A
----
R
A
T
D
-
I
V
---
A
K
L
G
L
P
L
F
V
K
P
A
S
-----
A
V
L
K
V
K
T
A
D
A
L
P
A
A
L
S
E
A
A
T
H
D
K
I
V
I
V
E
K
S
I
E
G
-
G
-
G
E
Y
T
A
C
I
A
G
D
L
--
D
L
------
P
L
I
---
K
I
V
-----
P
-------------------------
T
---------
Q
Y
L
I
P
C
G
L
P
A
E
Q
E
T
E
L
K
R
I
A
R
R
A
F
D
V
L
G
C
T
D
W
G
R
A
D
F
M
L
D
A
A
G
N
A
Y
F
L
E
V
N
T
A
P
G
M
T
D
H
S
L
P
P
K
A
A
R
S
I
G
I
G
Y
S
E
L
V
V
K
V
L
S
L
-------------
74
PsiBlast_CBE
58.69
31%
6
- C1 -
-
4C5B
3
DDLB_ECOLI
B:
[25-329]
M
T
D
K
I
A
V
L
L
G
G
T
S
A
E
R
E
V
S
L
N
S
G
A
A
V
L
AGL
R
E
G
G
-
I
-
D
A
Y
P
V
DP
K
E
--
V
D
V
T
Q
----
L
K
S
M
G
F
--------
Q
-------------
K
-----------------------------------------------------------------------------------------------
V
F
I
A
L
H
G
R
G
G
E
D
G
T
L
Q
G
M
L
E
L
M
G
L
P
Y
T
G
S
G
V
M
A
S
A
L
S
M
D
K
L
R
S
K
L
L
W
Q
G
A
-
G
-
L
P
V
A
P
W
V
A
L
-------
T
----
R
A
E
F
E
K
---
G
LSDK
Q
L
A
E
-
I
----
S
A
L
G
L
P
V
I
V
K
P
S
R
E
G
S
S
V
G
M
S
K
V
V
A
E
N
A
L
Q
D
A
L
R
L
A
F
Q
H
D
E
E
V
L
I
E
K
W
L
-
S
-
G
-
P
E
F
T
V
A
I
L
G
E
E
--
I
L
------
P
S
I
---
R
I
Q
-----
P
S
-----
G
T
F
Y
D
Y
E
A
K
Y
L
--
S
D
-
E
--
T
---------
Q
Y
F
C
P
A
G
L
E
A
S
Q
E
A
N
L
Q
A
L
V
L
K
A
W
T
T
L
G
C
K
G
W
G
R
I
D
V
M
L
D
S
D
G
Q
F
Y
L
L
E
A
N
T
S
P
G
M
T
S
H
S
L
V
P
M
A
A
R
Q
A
G
M
S
F
S
Q
L
V
V
R
I
L
E
L
A
------------
75
PsiBlast_CBE
58.64
31%
2
- C1 -
-
4C5B
6
DDLB_ECOLI
A:
[25-329]
M
T
D
K
I
A
V
L
L
G
G
T
S
A
E
R
E
V
S
L
N
S
G
A
A
V
L
A
G
L
R
E
G
G
-
I
-
D
A
Y
P
V
D
P
K
E
--
V
D
V
T
Q
----
L
K
S
M
G
F
--------
Q
-------------
K
-----------------------------------------------------------------------------------------------
V
F
I
A
L
H
G
R
G
G
E
D
G
T
L
Q
G
M
L
E
L
M
G
L
P
Y
T
G
S
G
V
M
A
S
A
L
S
M
D
K
L
R
S
K
L
L
W
Q
G
A
-
G
-
L
P
V
A
P
W
V
A
L
-------
T
----
R
A
E
F
E
K
---
G
LS
D
K
Q
L
A
E
-
I
----
S
A
L
G
L
P
V
I
V
K
P
S
R
E
G
S
S
V
G
M
S
K
V
V
A
E
N
A
L
Q
D
A
L
R
L
A
F
Q
H
D
E
E
V
L
I
E
K
W
L
-
S
-
G
-
P
E
F
T
V
A
I
L
G
E
E
--
I
L
------
P
S
I
---
R
I
Q
-----
P
S
-----
G
T
F
Y
D
Y
E
A
K
Y
L
--
S
D
-
E
--
T
---------
Q
Y
F
C
P
A
G
L
E
A
S
Q
E
A
N
L
Q
A
L
V
L
K
A
W
T
T
L
G
C
K
G
W
G
R
I
D
V
M
L
D
S
D
G
Q
F
Y
L
L
E
A
N
T
S
P
G
M
T
S
H
S
L
V
P
M
A
A
R
Q
A
G
M
S
F
S
Q
L
V
V
R
I
L
E
L
A
------------
72
PsiBlast_CBE
58.62
31%
3
- C1 -
-
4C5C
3
DDLB_ECOLI
B:
[25-329]
M
T
D
K
I
A
V
L
L
G
G
T
S
A
E
R
E
V
S
L
N
S
G
A
A
V
L
AGL
R
E
G
G
-
I
-
D
A
Y
P
V
DP
K
E
--
V
D
V
T
Q
----
L
K
S
M
G
F
--------
Q
-------------
K
-----------------------------------------------------------------------------------------------
V
F
I
A
L
H
G
R
G
G
E
D
G
T
L
Q
G
M
L
E
L
M
G
L
P
Y
T
G
S
G
V
M
A
S
A
L
S
M
D
K
L
R
S
K
L
L
W
Q
G
A
-
G
-
L
P
V
A
P
W
V
A
L
-------
T
----
R
A
E
F
E
K
---
G
LSDK
Q
L
A
E
-
I
----
S
A
L
G
L
P
V
I
V
K
P
S
R
E
G
S
S
V
G
M
S
K
V
V
A
E
N
A
L
Q
D
A
L
R
L
A
F
Q
H
D
E
E
V
L
I
E
K
W
L
-
S
-
G
-
P
E
F
T
V
A
I
L
G
E
E
--
I
L
------
P
S
I
---
R
I
Q
-----
P
S
-----
G
T
F
Y
D
Y
E
A
K
Y
L
--
S
D
-
E
--
T
---------
Q
Y
F
C
P
A
G
L
E
A
S
Q
E
A
N
L
Q
A
L
V
L
K
A
W
T
T
L
G
C
K
G
W
G
R
I
D
V
M
L
D
S
D
G
Q
F
Y
L
L
E
A
N
T
S
P
G
M
T
S
H
S
L
V
P
M
A
A
R
Q
A
G
M
S
F
S
Q
L
V
V
R
I
L
E
L
A
------------
81
Fugue
58.31
32%
23
- C1 -
-
1EHI
2
DDL_LEUMM
A:
[3-362]
-
K
K
R
V
A
L
I
F
G
G
N
S
S
E
H
D
V
S
K
R
S
A
Q
N
F
Y
---
N
A
I
E
-
A
T
G
K
Y
E
I
--
I
V
--
F
A
I
A
Q
N
G
F
F
L
D
T
E
S
S
--------
K
-------------
K
-------------
I
L
-
A
L
-
E
D
-
E
Q
P
----
I
--
V
D
A
---------------
F
M
-------
K
T
--
V
---
D
A
-----
S
D
P
-
L
A
R
I
H
A
L
K
SAGDFD
I
--
F
F
P
V
V
H
G
N
L
G
E
D
G
T
L
Q
G
L
F
K
L
L
D
K
P
Y
V
G
A
P
L
R
G
H
A
V
S
F
D
K
A
L
T
K
E
L
L
T
V
N
-
G
-
I
R
N
T
K
Y
I
V
V
-------
D
----
P
E
S
A
N
N
---
W
----
S
W
D
K
-
I
V
---
A
E
L
G
N
I
V
F
V
K
A
A
N
Q
G
S
S
V
G
I
S
R
V
T
N
A
E
E
Y
T
E
A
L
S
D
S
F
Q
Y
D
Y
K
V
L
I
E
E
A
V
N
G
-
A
-
R
E
L
E
V
G
V
I
G
N
D
--
Q
P
------
L
V
S
E
I
G
A
H
T
V
P
NQG
S
G
-----
D
G
W
Y
D
Y
N
N
K
F
V
--
D
N
S
A
--
V
---------
H
F
Q
I
P
A
Q
L
S
P
E
V
T
K
E
V
K
Q
M
A
L
D
A
Y
K
V
L
N
L
R
G
E
A
R
M
D
F
L
L
D
E
N
N
V
P
Y
L
G
E
P
N
T
L
P
G
F
T
N
M
S
L
F
K
R
L
W
D
Y
S
D
I
N
N
A
K
L
V
D
M
L
I
D
Y
G
F
E
D
F
A
Q
N
K
K
L
S
-
92
HHSearch
57.96
33%
6
- C1 -
-
1E4E
8
VANA_ENTFC
B:
[2-341]
N
R
I
K
V
A
I
L
F
G
G
C
S
E
E
H
D
V
S
V
K
S
A
I
E
I
A
---
A
N
I
N
-
K
-
E
K
Y
E
P
--
L
Y
--
I
G
I
T
K
S
G
V
W
K
M
C
E
K
P
CAEWENEN
C
-------------
Y
-------------
S
--
A
V
-
L
S
-
P
D
K
----
K
--
M
H
G
---------------
L
L
---------------
V
K
-----
K
N
H
-
E
Y
E
I
N
H
V
D
------
V
--
A
F
S
A
L
H
G
K
S
G
E
D
G
S
I
Q
G
L
F
E
L
S
G
I
P
F
V
G
C
D
I
Q
S
S
A
I
C
M
D
K
S
L
T
Y
I
V
A
K
N
A
-
G
-
I
A
T
P
A
F
W
V
I
-------
N
----
K
D
D
R
-------------
P
-
V
A
---
A
T
F
T
Y
P
V
F
V
K
P
A
R
S
G
S
S
F
G
V
K
K
V
N
S
A
D
E
L
D
Y
A
I
E
S
A
R
Q
Y
D
S
K
I
L
I
E
Q
A
V
-
S
-
G
-
C
E
V
G
C
A
V
L
G
N
S
A-
A
L
------
V
V
G
E
V
D
Q
I
R
-----
L
Q
-----
Y
G
I
F
R
I
H
Q
E
V
E
PE
K
G
-
S
EN
A
---------
V
I
T
V
P
A
D
L
S
A
E
E
R
G
R
I
Q
E
T
V
K
K
I
Y
K
T
L
G
C
R
G
L
A
R
V
D
M
F
L
Q
D
R
G
R
I
V
L
N
E
V
N
T
L
P
G
F
T
S
Y
S
R
Y
P
R
M
M
A
A
A
G
I
S
L
P
E
L
I
D
R
L
I
V
L
A
L
-----------
77
PsiBlast_CBE
57.71
31%
6
- C1 -
-
4C5A
4
DDLB_ECOLI
A:
[25-329]
M
T
D
K
I
A
V
L
L
G
G
T
S
A
E
R
E
V
S
L
N
S
G
A
A
V
L
A
G
L
R
E
G
G
-
I
-
D
A
Y
P
V
D
P
K
E
--
V
D
V
T
Q
----
L
K
S
M
G
F
--------
Q
-------------
K
-----------------------------------------------------------------------------------------------
V
F
I
A
L
H
G
R
G
G
E
D
G
T
L
Q
G
M
L
E
L
M
G
L
P
Y
T
G
S
G
V
M
A
S
A
L
S
M
D
K
L
R
S
K
L
L
W
Q
G
A
-
G
-
L
P
V
A
P
W
V
A
L
-------
T
----
R
A
E
F
E
K
---
G
LS
D
K
Q
L
A
E
-
I
----
S
A
L
G
L
P
V
I
V
K
P
S
R
E
G
S
S
V
G
M
S
K
V
V
A
E
N
A
L
Q
D
A
L
R
L
A
F
Q
H
D
E
E
V
L
I
E
K
W
L
-
S
-
G
-
P
E
F
T
V
A
I
L
G
E
E
--
I
L
------
P
S
I
---
R
I
Q
-----
P
S
-----
G
T
F
Y
D
Y
E
A
K
Y
L
--
S
D
-
E
--
T
---------
Q
Y
F
C
P
A
G
L
E
A
S
Q
E
A
N
L
Q
A
L
V
L
K
A
W
T
T
L
G
C
K
G
W
G
R
I
D
V
M
L
D
S
D
G
Q
F
Y
L
L
E
A
N
T
S
P
G
M
T
S
H
S
L
V
P
M
A
A
R
Q
A
G
M
S
F
S
Q
L
V
V
R
I
L
E
L
A
------------
71
PsiBlast_CBE
56.92
31%
3
- C1 -
-
1IOV
2
DDLB_ECOLI
A:
[1-305]
M
T
D
K
I
A
V
L
L
G
G
T
S
A
E
R
E
V
S
L
N
S
G
A
A
V
L
A
G
L
R
E
G
G
-
I
-
D
A
Y
P
V
DP
K
E
--
V
D
V
T
Q
----
L
K
S
M
G
F
--------
Q
-------------
K
-----------------------------------------------------------------------------------------------
V
F
I
A
L
H
G
R
G
G
E
D
G
T
L
Q
G
M
L
E
L
M
G
L
P
Y
T
G
S
G
V
M
A
S
A
L
S
M
D
K
L
R
S
K
L
L
W
Q
G
A
-
G
-
L
P
V
A
P
W
V
A
L
-------
T
R
A
E
F
E
K
G
L
S
D
---
K
----
Q
L
A
E
-
I
----
S
A
L
G
L
P
V
I
V
K
P
S
R
E
G
S
S
V
G
M
S
K
V
V
A
E
N
A
L
Q
D
A
L
R
L
A
F
Q
H
D
E
E
V
L
I
E
K
W
L
-
S
-
G
-
P
E
F
T
V
A
I
L
G
E
E
--
I
L
------
P
S
I
---
R
I
Q
-----
P
S
-----
G
T
F
Y
D
Y
E
A
K
Y
L
--
S
D
-
E
--
T
---------
Q
Y
F
C
P
A
G
L
E
A
S
Q
E
A
N
L
Q
A
L
V
L
K
A
W
T
T
L
G
C
K
G
W
G
R
I
D
V
M
L
D
S
D
G
Q
F
Y
L
L
E
A
N
T
S
P
G
M
T
S
H
S
L
V
P
M
A
A
R
Q
A
G
M
S
F
S
Q
L
V
V
R
I
L
E
L
A
------------
70
PsiBlast_CBE
55.29
31%
-0
- C1 -
-
2DLN
2
DDLB_ECOLI
A:
[1-305]
M
T
D
K
I
A
V
L
L
G
G
T
S
A
E
R
E
V
S
L
N
S
G
A
A
V
L
A
G
L
R
E
G
G
-
I
-
D
A
Y
P
V
D
P
K
E
--
V
D
V
T
Q
----
L
K
S
M
G
F
--------
Q
-------------
K
-----------------------------------------------------------------------------------------------
V
F
I
A
L
H
G
R
G
G
E
D
G
T
L
Q
G
M
L
E
L
M
G
L
P
Y
T
G
S
G
V
M
A
S
A
L
S
M
D
K
L
R
S
K
L
L
W
Q
G
A
-
G
-
L
P
V
A
P
W
V
A
L
-------
T
R
A
E
F
E
K
G
L
S
D
---
K
----
Q
L
A
E
-
I
----
S
A
L
G
L
P
V
I
V
K
P
S
R
E
G
S
S
V
G
M
S
K
V
V
A
E
N
A
L
Q
D
A
L
R
L
A
F
Q
H
D
E
E
V
L
I
E
K
W
L
-
S
-
G
-
P
E
F
T
V
A
I
L
G
E
E
--
I
L
------
P
S
I
---
R
I
Q
-----
P
S
-----
G
T
F
Y
D
Y
E
A
K
Y
L
--
S
D
-
E
--
T
---------
Q
Y
F
C
P
A
G
L
E
A
S
Q
E
A
N
L
Q
A
L
V
L
K
A
W
T
T
L
G
C
K
G
W
G
R
I
D
V
M
L
D
S
D
G
Q
F
Y
L
L
E
A
N
T
S
P
G
M
T
S
H
S
L
V
P
M
A
A
R
Q
A
G
M
S
F
S
Q
L
V
V
R
I
L
E
L
A
------------
86
Fugue
33.95
36%
-124
- C1 -
-
1IOW
1
?
?:
[1-96]
M
T
D
K
I
A
V
L
L
G
G
T
S
A
E
R
E
V
S
L
N
S
G
A
A
V
L
---
A
G
L
R
-
E
-
G
G
I
D
A
--
Y
P
--
V
------------------------------------------------------------------------------------------------
D
P
--
K
---
E
V
-----
D
V
T
-
Q
L
K
S
M
G
F
Q
------
K
--
V
F
I
A
L
H
G
R
G
G
E
D
G
T
L
Q
G
M
L
E
L
M
G
L
P
Y
T
G
S
G
V
M
A
S
A
L
S
M
D
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
83
Fugue
29.39
35%
55
- C1 -
-
1EHI
2
DDL_LEUMM
A:
[135-362]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
A
L
T
K
E
L
L
T
V
N
-
G
-
I
R
N
T
K
Y
I
V
V
-------
D
----
P
E
S
A
N
N
W
S-------
W
D
K
-
I
V
---
A
E
L
G
N
I
V
F
V
K
A
A
N
Q
G
S
S
V
G
I
S
R
V
T
N
A
E
E
Y
T
E
A
L
S
D
S
F
Q
Y
D
Y
K
V
L
I
E
E
A
V
N
G
-
A
-
R
E
L
E
V
G
V
I
G
N
D
--
Q
P
------
L
V
S
E
I
G
A
H
T
V
P
NQG
S
G
-----
D
G
W
Y
D
Y
N
N
K
F
V
--
D
N
S
A
--
V
---------
H
F
Q
I
P
A
Q
L
S
P
E
V
T
K
E
V
K
Q
M
A
L
D
A
Y
K
V
L
N
L
R
G
E
A
R
M
D
F
L
L
D
E
N
N
V
P
Y
L
G
E
P
N
T
L
P
G
F
T
N
M
S
L
F
K
R
L
W
D
Y
S
D
I
N
N
A
K
L
V
D
M
L
I
D
Y
G
F
E
D
F
A
Q
N
K
K
L
S
-