@TOME V2.3
(Mar 2018)
Ref.
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : spr1536: (2018-01-14 )
MSYFRNRDIDIERNSMNRSVQERKCRYSIRKLSVGAVSMIVGAVVFGTSPVLAQEGASEQPLANETQLSGESSTLTDTEKSQPSSETELSGNKQEQERKDKQEEKIPRDYYARDLENVETVIEKEDVETNASNGQRVDLSSELDKLKKLENATVHMEFKPDAKAPAFYNLFSVSSATKKDEYFTMAVYNNTATLEGRGSDGKQFYNNYNDAPLKVKPGQWNSVTFTVEKPTAELPKGRVRLYVNGVLSRTSLRSGNFIKDMPDVTHVQIGATKRANNTVWGSNLQIRNLTVYNRALTPEEVQKRSQLFKRSDLEKKLPEGAALTEKTDIFESGRNGKPNKDGIKSYRIPALLKTDKGTLIAGADERRLHSSDWGDIGMVIRRSEDNGKTWGDRVTITNLRDNPKASDPSIGSPVNIDMVLVQDPETKRIFSIYDMFPEGKGIFGMSSQKEEAYKKIDGKTYQILYREGEKGAYTIRENGTVYTPDGKATDYRVVVDPVKPAYSDKGDLYKGNQLLGNIYFTTNKTSPFRIAKDSYLWMSYSDDDGKTWSAPQDITPMVKADWMKFLGVGPGTGIVLRNGPHKGRILIPVYTTNNVSHLNGSQSSRIIYSDDHGKTWHAGEAVNDNRQVDGQKIHSSTMNNRRAQNTESTVVQLNNGDVKLFMRGLTGDLQVATSKDGGVTWEKDIKRYPQVKDVYVQMSAIHTMHEGKEYIILSNAGGPKRENGMVHLARVEENGELTWLKHNPIQKGEFAYNSLQELGNGEYGILYEHTEKGQNAYTLSFRKFNWDFLSKDLISPTEAKVKRTREMGKGVIGLEFDSEVLVNKAPTLQLANGKTARFMTQYDTKTLLFTVDSEDMGQKVTGLAEGAIESMHNLPVSVAGTKLSNGMNGSEAAVHEVPEYTGPLGTSGEEPAPTVEKPEYTGPLGTSGEEPAPTVEKPEYTGPLGTAGEEAAPTVEKPEFTGGVNGTEPAVHEIAEYKGSDSLVTLTTKEDYTYKAPLAQQALPETGNKESDLLASLGLTAFFLGLFTLGKKREQ
Atome Classification :
(30 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.--......380.......390.......400.......410.......420.......430.......440.--......450.......460.......470.......480.......490.......500.......510.......520........530.......540.......550.......560.......570.......580.......590.......600.......610.......620......-.630........640.......650.......660.......670.......680.......690.......700.--..--....710.......720.......730-----...----..-----..740.......750.......760.......770.......780.......790.......800.......810.......820.......830.......840.......850.......860.......870.......880.......890.......900.......910.......920.......930.......940.......950.......960.......970.......980.......990.......1000......1010......1020......1030..
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MSYFRNRDI
D
I
ERNSMN
R
S
V
Q
E
R
K
C
R
Y
S
I
R
KLS
V
G
A
V
S
M
I
V
G
A
V
V
FGTSPVLAQEGASEQPLANETQLSGESSTLTDTEKSQPSSETELSG
N
K
Q
E
Q
E
R
K
D
K
Q
E
EKI
P
R
D
Y
Y
A
R
D
L
E
N
V
E
T
V
I
E
K
EDVETNASNG
Q
R
V
D
L
S
S
E
L
D
K
L
K
K
LEN
A
T
V
H
M
E
FKPDAKA
P
A
F
Y
N
L
F
SVSSATKKD
E
Y
F
T
M
A
V
YN
N
T
A
T
L
EGRGSD
G
K
Q
F
Y
NNYNDAP
L
K
VKPGQW
N
S
V
T
F
T
VEKPTAELPK
G
R
V
R
L
Y
V
NGVLSRTSLRSGNFIKDMPDV
T
H
V
Q
IGATKRANNTVWGSN
L
Q
I
R
N
L
T
V
YNRAL
T
P
E
E
V
Q
K
R
S
Q
L
F
K
R
S
D
L
E
K
KLPEGAALT
E
K
T
D
I
F
ESGRNGKPNKDGIKSYR
I
P
A
L
L
KTDKG
T
L
I
AGADERRLHSSDW--GD
I
G
M
V
I
R
RSEDNGKTWG
D
R
V
T
I
TNLRDNPKASDPSIGS
P
V
N
I
D
M
V
L
VQDPET
K
R
I
F
S
I
Y
DMFPEGKGIF--GMSS
Q
K
E
E
A
Y
K
KIDG
K
T
Y
Q
I
L
Y
REGEK
G
A
Y
T
I
REN
G
T
V
YTPDGKAT
D
Y
R
V
V
VDPVKPAYSDKGDLYKG
N
Q
L
L
G
N
I
Y
F
-TTNKTS
P
F
R
IAKD
S
Y
L
W
M
S
YSDDDGKTWSAPQDI
T
P
M
V
K
A
D
W
M
K
F
LGVGPG
T
G
I
V
LRNGPHK
G
R
I
L
I
P
V
YTTNNVSHLNGSQS
S
R
I
I
Y
SDDHGKTWHAGEAVNDNRQV-D
G
Q
-
K
I
H
S
S
TMNNRRAQNTE
S
T
V
V
Q
LNNG
D
V
K
L
F
M
RGLTG
D
L
Q
V
A
TSKDG
G
V
T
W
E
K
D
I
K
RYP
Q
V
K
D
V
Y
V
Q
M
S
A
I
H
T
--MH--EGK
E
Y
I
I
L
SNAGGPKREN
G
M
V
H
L
A
R
VE-----ENG----
E
L
-----
T
W
L
KHNPIQKG
E
F
A
Y
N
S
L
Q
E
LGNGE
Y
G
I
L
Y
E
HTEKGQ
N
A
Y
T
L
S
F
RKF
N
W
D
F
L
S
K
DLISP
T
E
A
K
V
K
R
T
R
E
MGK
G
V
I
G
L
EFDSEVLVNKA
P
T
L
Q
LANGK
T
A
R
F
M
T
QYDT
K
T
L
L
F
T
VD
S
E
DM
G
Q
K
V
T
G
L
A
E
G
A
I
E
S
M
HNLP
V
S
VAGTKLSNGMNG
S
E
A
A
V
HEVPEYTGPLGTSGEEPAPTVEKPEYTGPLGTSGEEPAPTVEKPEYTGPLGTAGEEAAPTVEKPEFTGGVNGT
E
P
A
V
H
E
I
A
E
YKGSD
S
L
V
T
L
TTKED
Y
T
YKAP
L
A
Q
QALPETGN
K
E
S
D
L
L
A
S
L
G
L
T
A
F
F
L
G
L
F
T
LGKKREQ
23
PsiBlast_CBE
93.59
100%
-32
- C5 -
-
3H72
1
NANA_STRR6
B:
[1-477]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
E
G
A
A
L
T
E
K
T
D
I
F
E
S
G
R
N
G
K
P
N
K
D
G
I
K
S
Y
R
I
P
A
L
L
K
T
D
K
G
T
L
I
A
G
A
D
E
R
R
L
H
S
S
D
W
--
G
D
I
G
M
V
I
R
R
S
E
D
N
G
K
T
W
G
D
R
V
T
I
T
N
L
R
D
N
P
K
A
S
D
P
S
I
G
S
P
V
N
I
D
M
V
L
V
Q
D
P
E
T
K
R
I
F
S
I
Y
D
M
F
P
E
G
K
G
I
F
--
G
M
S
S
Q
K
E
E
A
Y
K
K
I
D
G
K
T
Y
Q
I
L
Y
R
E
G
E
K
G
A
Y
T
I
R
E
N
G
T
V
Y
T
P
D
G
K
A
T
D
Y
R
V
V
V
D
P
V
K
P
A
Y
S
D
K
G
D
L
Y
K
G
N
Q
L
L
G
N
I
Y
F
-
T
T
N
K
T
S
P
F
R
I
A
K
D
S
Y
L
W
M
S
Y
S
D
D
D
G
K
T
W
S
A
P
Q
D
I
T
P
M
V
K
A
D
W
M
K
F
L
G
V
G
P
G
T
G
I
V
L
R
N
G
P
H
K
G
R
I
L
I
P
V
Y
T
T
N
N
V
S
H
L
N
G
S
Q
S
S
R
I
I
Y
S
D
D
H
G
K
T
W
H
A
G
E
A
V
N
D
N
R
Q
V
-
D
G
Q
-
K
I
H
S
S
T
M
N
N
R
R
A
Q
N
T
E
S
T
V
V
Q
L
N
N
G
D
V
K
L
F
M
R
G
L
T
G
D
L
Q
V
A
T
S
K
D
G
G
V
T
W
E
K
D
I
K
R
Y
P
Q
V
K
D
V
Y
V
Q
M
S
A
I
H
T
--
M
H
--
E
G
K
E
Y
I
I
L
S
N
A
G
G
P
K
R
E
N
G
M
V
H
L
A
R
V
E
-----
E
N
G
----
E
L
-----
T
W
L
K
H
N
P
I
Q
K
G
E
F
A
Y
N
S
L
Q
E
L
G
N
G
E
Y
G
I
L
Y
E
H
T
E
K
G
Q
N
A
Y
T
L
S
F
R
K
F
N
W
D
F
L
S
K
D
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
93.06
100%
-31
- C5 -
-
3H73
1
NANA_STRR6
A:
[4-477]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
A
A
L
T
E
K
T
D
I
F
E
S
G
R
N
G
K
P
N
K
D
G
I
K
S
Y
R
I
P
A
L
L
K
T
D
K
G
T
L
I
A
G
A
D
E
R
R
L
H
S
S
D
W
--
G
D
I
G
M
V
I
R
R
S
E
D
N
G
K
T
W
G
D
R
V
T
I
T
N
L
R
D
N
P
K
A
S
D
P
S
I
G
S
P
V
N
I
D
M
V
L
V
Q
D
P
E
T
K
R
I
F
S
I
Y
D
M
F
P
E
G
K
G
I
F
--
G
M
S
S
Q
K
E
E
A
Y
K
K
I
D
G
K
T
Y
Q
I
L
Y
R
E
G
E
K
G
A
Y
T
I
R
E
N
G
T
V
Y
T
P
D
G
K
A
T
D
Y
R
V
V
V
D
P
V
K
P
A
Y
S
D
K
G
D
L
Y
K
G
N
Q
L
L
G
N
I
Y
F
-
T
T
N
K
T
S
P
F
R
I
A
K
D
S
Y
L
W
M
S
Y
S
D
D
D
G
K
T
W
S
A
P
Q
D
I
T
P
M
V
K
A
D
W
M
K
F
L
G
V
G
P
G
T
G
I
V
L
R
N
G
P
H
K
G
R
I
L
I
P
V
Y
T
T
N
N
V
S
H
L
N
G
S
Q
S
S
R
I
I
Y
S
D
D
H
G
K
T
W
H
A
G
E
A
V
N
D
N
R
Q
V
-
D
G
Q
-
K
I
H
S
S
T
M
N
N
R
R
A
Q
N
T
E
S
T
V
V
Q
L
N
N
G
D
V
K
L
F
M
R
G
L
T
G
D
L
Q
V
A
T
S
K
D
G
G
V
T
W
E
K
D
I
K
R
Y
P
Q
V
K
D
V
Y
V
Q
M
S
A
I
H
T
--
M
H
--
E
G
K
E
Y
I
I
L
S
N
A
G
G
P
K
R
E
N
G
M
V
H
L
A
R
V
E
-----
E
N
G
----
E
L
-----
T
W
L
K
H
N
P
I
Q
K
G
E
F
A
Y
N
S
L
Q
E
L
G
N
G
E
Y
G
I
L
Y
E
H
T
E
K
G
Q
N
A
Y
T
L
S
F
R
K
F
N
W
D
F
L
S
K
D
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
92.87
100%
-29
- C5 -
-
3H72
1
NANA_STRR6
A:
[4-477]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
A
A
L
T
E
K
T
D
I
F
E
S
G
R
N
G
K
P
N
K
D
G
I
K
S
Y
R
I
P
A
L
L
K
T
D
K
G
T
L
I
A
G
A
D
E
R
R
L
H
S
S
D
W
--
G
D
I
G
M
V
I
R
R
S
E
D
N
G
K
T
W
G
D
R
V
T
I
T
N
L
R
D
N
P
K
A
S
D
P
S
I
G
S
P
V
N
I
D
M
V
L
V
Q
D
P
E
T
K
R
I
F
S
I
Y
D
M
F
P
E
G
K
G
I
F
--
G
M
S
S
Q
K
E
E
A
Y
K
K
I
D
G
K
T
Y
Q
I
L
Y
R
E
G
E
K
G
A
Y
T
I
R
E
N
G
T
V
Y
T
P
D
G
K
A
T
D
Y
R
V
V
V
D
P
V
K
P
A
Y
S
D
K
G
D
L
Y
K
G
N
Q
L
L
G
N
I
Y
F
-
T
T
N
K
T
S
P
F
R
I
A
K
D
S
Y
L
W
M
S
Y
S
D
D
D
G
K
T
W
S
A
P
Q
D
I
T
P
M
V
K
A
D
W
M
K
F
L
G
V
G
P
G
T
G
I
V
L
R
N
G
P
H
K
G
R
I
L
I
P
V
Y
T
T
N
N
V
S
H
L
N
G
S
Q
S
S
R
I
I
Y
S
D
D
H
G
K
T
W
H
A
G
E
A
V
N
D
N
R
Q
V
-
D
G
Q
-
K
I
H
S
S
T
M
N
N
R
R
A
Q
N
T
E
S
T
V
V
Q
L
N
N
G
D
V
K
L
F
M
R
G
L
T
G
D
L
Q
V
A
T
S
K
D
G
G
V
T
W
E
K
D
I
K
R
Y
P
Q
V
K
D
V
Y
V
Q
M
S
A
I
H
T
--
M
H
--
E
G
K
E
Y
I
I
L
S
N
A
G
G
P
K
R
E
N
G
M
V
H
L
A
R
V
E
-----
E
N
G
----
E
L
-----
T
W
L
K
H
N
P
I
Q
K
G
E
F
A
Y
N
S
L
Q
E
L
G
N
G
E
Y
G
I
L
Y
E
H
T
E
K
G
Q
N
A
Y
T
L
S
F
R
K
F
N
W
D
F
L
S
K
D
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
PsiBlast_CBE
92.85
100%
-30
- C5 -
-
3H73
1
NANA_STRR6
B:
[1-477]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
E
G
A
A
L
T
E
K
T
D
I
F
E
S
G
R
N
G
K
P
N
K
D
G
I
K
S
Y
R
I
P
A
L
L
K
T
D
K
G
T
L
I
A
G
A
D
E
R
R
L
H
S
S
D
W
--
G
D
I
G
M
V
I
R
R
S
E
D
N
G
K
T
W
G
D
R
V
T
I
T
N
L
R
D
N
P
K
A
S
D
P
S
I
G
S
P
V
N
I
D
M
V
L
V
Q
D
P
E
T
K
R
I
F
S
I
Y
D
M
F
P
E
G
K
G
I
F
--
G
M
S
S
Q
K
E
E
A
Y
K
K
I
D
G
K
T
Y
Q
I
L
Y
R
E
G
E
K
G
A
Y
T
I
R
E
N
G
T
V
Y
T
P
D
G
K
A
T
D
Y
R
V
V
V
D
P
V
K
P
A
Y
S
D
K
G
D
L
Y
K
G
N
Q
L
L
G
N
I
Y
F
-
T
T
N
K
T
S
P
F
R
I
A
K
D
S
Y
L
W
M
S
Y
S
D
D
D
G
K
T
W
S
A
P
Q
D
I
T
P
M
V
K
A
D
W
M
K
F
L
G
V
G
P
G
T
G
I
V
L
R
N
G
P
H
K
G
R
I
L
I
P
V
Y
T
T
N
N
V
S
H
L
N
G
S
Q
S
S
R
I
I
Y
S
D
D
H
G
K
T
W
H
A
G
E
A
V
N
D
N
R
Q
V
-
D
G
Q
-
K
I
H
S
S
T
M
N
N
R
R
A
Q
N
T
E
S
T
V
V
Q
L
N
N
G
D
V
K
L
F
M
R
G
L
T
G
D
L
Q
V
A
T
S
K
D
G
G
V
T
W
E
K
D
I
K
R
Y
P
Q
V
K
D
V
Y
V
Q
M
S
A
I
H
T
--
M
H
--
E
G
K
E
Y
I
I
L
S
N
A
G
G
P
K
R
E
N
G
M
V
H
L
A
R
V
E
-----
E
N
G
----
E
L
-----
T
W
L
K
H
N
P
I
Q
K
G
E
F
A
Y
N
S
L
Q
E
L
G
N
G
E
Y
G
I
L
Y
E
H
T
E
K
G
Q
N
A
Y
T
L
S
F
R
K
F
N
W
D
F
L
S
K
D
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
92.64
97%
-31
- C5 -
-
3H71
-
NANA_STRR6
A:
[320-793]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
A
A
L
T
E
K
T
D
I
F
E
S
G
R
N
G
K
P
N
K
D
G
I
K
S
Y
R
I
P
A
L
L
K
T
D
K
G
T
L
I
A
G
A
D
E
R
R
L
H
S
S
D
W
--
G
D
I
G
M
V
I
R
R
S
E
D
N
G
K
T
W
G
D
R
V
T
I
T
N
L
R
D
N
P
K
A
S
D
P
S
I
G
S
P
V
N
I
D
M
V
L
V
Q
D
P
E
T
K
R
I
F
S
I
Y
D
M
F
P
E
G
K
G
I
F
--
G
M
S
S
Q
K
E
E
A
Y
K
K
I
D
G
K
T
Y
Q
I
L
Y
R
E
G
E
K
G
A
Y
T
I
R
E
N
G
T
V
Y
T
P
D
G
K
A
T
D
Y
R
V
V
V
D
P
V
K
P
A
Y
S
D
K
G
D
L
Y
K
G
N
Q
L
L
G
N
I
Y
F
-
T
T
N
K
T
S
P
F
R
I
A
K
D
S
Y
L
W
M
S
Y
S
D
D
D
G
K
T
W
S
A
P
Q
D
I
T
P
M
V
K
A
D
W
M
K
F
L
G
V
G
P
G
T
G
I
V
L
R
N
G
P
H
K
G
R
I
L
I
P
V
Y
T
T
N
N
V
S
H
L
N
G
S
Q
S
S
R
I
I
Y
S
D
D
H
G
K
T
W
H
A
G
E
A
V
N
D
N
R
Q
V
-
D
G
Q
-
K
I
H
S
S
T
M
N
N
R
R
A
Q
N
T
E
S
T
V
V
Q
L
N
N
G
D
V
K
L
F
M
R
G
L
T
G
D
L
Q
V
A
T
S
K
D
G
G
V
T
W
E
K
D
I
K
R
Y
P
Q
V
K
D
V
Y
V
Q
M
S
A
I
H
T
--
M
H
--
E
G
K
E
Y
I
I
L
S
N
A
G
G
P
K
R
E
N
G
M
V
H
L
A
R
V
E
-----
E
N
G
----
E
L
-----
T
W
L
K
H
N
P
I
Q
K
G
E
F
A
Y
N
S
L
Q
E
L
G
N
G
E
Y
G
I
L
Y
E
H
T
E
K
G
Q
N
A
Y
T
L
S
F
R
K
F
N
W
D
F
L
S
K
D
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
92.46
98%
-30
- C5 -
-
5KKY
1
?
A:
[26-496]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
L
T
E
K
T
D
I
F
E
S
G
R
N
G
N
P
N
K
D
G
I
K
S
Y
R
I
P
A
L
L
K
T
D
K
G
T
L
I
A
G
A
D
E
R
R
L
H
S
S
D
W
--
G
D
I
G
M
V
I
R
R
S
E
D
N
G
K
T
W
G
D
R
V
T
I
T
N
L
R
D
N
P
K
A
S
D
P
S
I
G
S
P
V
N
I
D
M
V
L
V
Q
D
P
E
T
K
R
I
F
S
I
Y
D
M
F
P
E
G
K
G
I
F
--
G
M
S
S
Q
K
E
E
A
Y
K
K
I
D
G
K
T
Y
Q
I
L
Y
R
E
G
E
K
G
A
Y
T
I
R
E
N
G
T
V
Y
T
P
D
G
K
A
T
D
Y
R
V
V
V
D
P
V
K
P
A
Y
S
D
K
G
D
L
Y
K
G
D
Q
L
L
G
N
I
Y
F
-
T
T
N
K
T
S
P
F
R
I
A
K
D
S
Y
L
W
M
S
Y
S
D
D
D
G
K
T
W
S
A
P
Q
D
I
T
P
M
V
K
A
D
W
M
K
F
L
G
V
G
P
G
T
G
I
V
L
R
N
G
P
H
K
G
R
I
L
I
P
V
Y
T
T
N
N
V
S
H
L
D
G
S
Q
S
S
R
V
I
Y
S
D
D
H
G
K
T
W
H
A
G
E
A
V
N
D
N
R
Q
V
-
D
G
Q
-
K
I
H
S
S
T
M
N
N
R
R
A
Q
N
T
E
S
T
V
V
Q
L
N
N
G
D
V
K
L
F
M
R
G
L
T
G
D
L
Q
V
A
T
S
K
D
G
G
V
T
W
E
K
D
I
K
R
Y
P
Q
V
K
D
V
Y
V
Q
M
S
A
I
H
T
--
M
H
--
E
G
K
E
Y
I
I
L
S
N
A
G
G
P
K
R
E
N
G
M
V
H
L
A
R
V
E
-----
E
N
G
----
E
L
-----
T
W
L
K
H
N
P
I
Q
K
G
E
F
A
Y
N
S
L
Q
E
L
G
N
G
E
Y
G
I
L
Y
E
H
T
E
K
G
Q
N
A
Y
T
L
S
F
R
K
F
N
W
E
F
L
S
K
N
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
92.40
98%
-33
- C5 -
-
2YA7
1
NANA_STREE
A:
[23-491]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
L
T
E
K
T
D
I
F
E
S
G
R
N
G
N
P
N
K
D
G
I
K
S
Y
R
I
P
A
L
L
K
T
D
K
G
T
L
I
A
G
A
D
E
R
R
L
H
S
S
D
W
--
G
D
I
G
M
V
I
R
R
S
E
D
N
G
K
T
W
G
D
R
V
T
I
T
N
L
R
D
N
P
K
A
S
D
P
S
I
G
S
P
V
N
I
D
M
V
L
V
Q
D
P
E
T
K
R
I
F
S
I
Y
D
M
F
P
E
G
K
G
I
F
--
G
M
S
S
Q
K
E
E
A
Y
K
K
I
D
G
K
T
Y
Q
I
L
Y
R
E
G
E
K
G
A
Y
T
I
R
E
N
G
T
V
Y
T
P
D
G
K
A
T
D
Y
R
V
V
V
D
P
V
K
P
A
Y
S
D
K
G
D
L
Y
K
G
D
Q
L
L
G
N
I
Y
F
-
T
T
N
K
T
S
P
F
R
I
A
K
D
S
Y
L
W
M
S
Y
S
D
D
D
G
K
T
W
S
A
P
Q
D
I
T
P
M
V
K
A
D
W
M
K
F
L
G
V
G
P
G
T
G
I
V
L
R
N
G
P
H
K
G
R
I
L
I
P
V
Y
T
T
N
N
V
S
H
L
D
G
S
Q
S
S
R
V
I
Y
S
D
D
H
G
K
T
W
H
A
G
E
A
V
N
D
N
R
Q
V
-
D
G
Q
-
K
I
H
S
S
T
M
N
N
R
R
A
Q
N
T
E
S
T
V
V
Q
L
N
N
G
D
V
K
L
F
M
R
G
L
T
G
D
L
Q
V
A
T
S
K
D
G
G
V
T
W
E
K
D
I
K
R
Y
P
Q
V
K
D
V
Y
V
Q
M
S
A
I
H
T
--
M
H
--
E
G
K
E
Y
I
I
L
S
N
A
G
G
P
K
R
E
N
G
M
V
H
L
A
R
V
E
-----
E
N
G
----
E
L
-----
T
W
L
K
H
N
P
I
Q
K
G
E
F
A
Y
N
S
L
Q
E
L
G
N
G
E
Y
G
I
L
Y
E
H
T
E
K
G
Q
N
A
Y
T
L
S
F
R
K
F
N
W
E
F
L
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
92.19
100%
-31
- C5 -
-
2W20
5
NANA_STRR6
A:
[1-470]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
A
L
T
E
K
T
D
I
F
E
S
G
R
N
G
K
P
N
K
D
G
I
K
S
Y
R
I
P
A
L
L
K
T
D
K
G
T
L
I
A
G
A
D
E
R
R
L
H
S
S
D
W
--
G
D
I
G
M
V
I
R
R
S
E
D
N
G
K
T
W
G
D
R
V
T
I
T
N
L
R
D
N
P
K
A
S
D
P
S
I
G
S
P
V
N
I
D
M
V
L
V
Q
D
P
E
T
K
R
I
F
S
I
Y
D
M
F
P
E
G
K
G
I
F
--
G
M
S
S
Q
K
E
E
A
Y
K
K
I
D
G
K
T
Y
Q
I
L
Y
R
E
G
E
K
G
A
Y
T
I
R
E
N
G
T
V
Y
T
P
D
G
K
A
T
D
Y
R
V
V
V
D
P
V
K
P
A
Y
S
D
K
G
D
L
Y
K
G
N
Q
L
L
G
N
I
Y
F
-
T
T
N
K
T
S
P
F
R
I
A
K
D
S
Y
L
W
M
S
Y
S
D
D
D
G
K
T
W
S
A
P
Q
D
I
T
P
M
V
K
A
D
W
M
K
F
L
G
V
G
P
G
T
G
I
V
L
R
N
G
P
H
K
G
R
I
L
I
P
V
Y
T
T
N
N
V
S
H
L
N
G
S
Q
S
S
R
I
I
Y
S
D
D
H
G
K
T
W
H
A
G
E
A
V
N
D
N
R
Q
V
-
D
G
Q
-
K
I
H
S
S
T
M
N
N
R
R
A
Q
N
T
E
S
T
V
V
Q
L
N
N
G
D
V
K
L
F
M
R
G
L
T
G
D
L
Q
V
A
T
S
K
D
G
G
V
T
W
E
K
D
I
K
R
Y
P
Q
V
K
D
V
Y
V
Q
M
S
A
I
H
T
--
M
H
--
E
G
K
E
Y
I
I
L
S
N
A
G
G
P
K
R
E
N
G
M
V
H
L
A
R
V
E
-----
E
N
G
----
E
L
-----
T
W
L
K
H
N
P
I
Q
K
G
E
F
A
Y
N
S
L
Q
E
L
G
N
G
E
Y
G
I
L
Y
E
H
T
E
K
G
Q
N
A
Y
T
L
S
F
R
K
F
N
W
D
F
L
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
PsiBlast_CBE
92.16
98%
-29
- C5 -
-
5KKY
1
?
B:
[26-495]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
L
T
E
K
T
D
I
F
E
S
G
R
N
G
N
P
N
K
D
G
I
K
S
Y
R
I
P
A
L
L
K
T
D
K
G
T
L
I
A
G
A
D
E
R
R
L
H
S
S
D
W
--
G
D
I
G
M
V
I
R
R
S
E
D
N
G
K
T
W
G
D
R
V
T
I
T
N
L
R
D
N
P
K
A
S
D
P
S
I
G
S
P
V
N
I
D
M
V
L
V
Q
D
P
E
T
K
R
I
F
S
I
Y
D
M
F
P
E
G
K
G
I
F
--
G
M
S
S
Q
K
E
E
A
Y
K
K
I
D
G
K
T
Y
Q
I
L
Y
R
E
G
E
K
G
A
Y
T
I
R
E
N
G
T
V
Y
T
P
D
G
K
A
T
D
Y
R
V
V
V
D
P
V
K
P
A
Y
S
D
K
G
D
L
Y
K
G
D
Q
L
L
G
N
I
Y
F
-
T
T
N
K
T
S
P
F
R
I
A
K
D
S
Y
L
W
M
S
Y
S
D
D
D
G
K
T
W
S
A
P
Q
D
I
T
P
M
V
K
A
D
W
M
K
F
L
G
V
G
P
G
T
G
I
V
L
R
N
G
P
H
K
G
R
I
L
I
P
V
Y
T
T
N
N
V
S
H
L
D
G
S
Q
S
S
R
V
I
Y
S
D
D
H
G
K
T
W
H
A
G
E
A
V
N
D
N
R
Q
V
-
D
G
Q
-
K
I
H
S
S
T
M
N
N
R
R
A
Q
N
T
E
S
T
V
V
Q
L
N
N
G
D
V
K
L
F
M
R
G
L
T
G
D
L
Q
V
A
T
S
K
D
G
G
V
T
W
E
K
D
I
K
R
Y
P
Q
V
K
D
V
Y
V
Q
M
S
A
I
H
T
--
M
H
--
E
G
K
E
Y
I
I
L
S
N
A
G
G
P
K
R
E
N
G
M
V
H
L
A
R
V
E
-----
E
N
G
----
E
L
-----
T
W
L
K
H
N
P
I
Q
K
G
E
F
A
Y
N
S
L
Q
E
L
G
N
G
E
Y
G
I
L
Y
E
H
T
E
K
G
Q
N
A
Y
T
L
S
F
R
K
F
N
W
E
F
L
S
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
29
PsiBlast_CBE
91.99
98%
-31
- C5 -
-
2YA7
1
NANA_STREE
B:
[23-490]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
L
T
E
K
T
D
I
F
E
S
G
R
N
G
N
P
N
K
D
G
I
K
S
Y
R
I
P
A
L
L
K
T
D
K
G
T
L
I
A
G
A
D
E
R
R
L
H
S
S
D
W
--
G
D
I
G
M
V
I
R
R
S
E
D
N
G
K
T
W
G
D
R
V
T
I
T
N
L
R
D
N
P
K
A
S
D
P
S
I
G
S
P
V
N
I
D
M
V
L
V
Q
D
P
E
T
K
R
I
F
S
I
Y
D
M
F
P
E
G
K
G
I
F
--
G
M
S
S
Q
K
E
E
A
Y
K
K
I
D
G
K
T
Y
Q
I
L
Y
R
E
G
E
K
G
A
Y
T
I
R
E
N
G
T
V
Y
T
P
D
G
K
A
T
D
Y
R
V
V
V
D
P
V
K
P
A
Y
S
D
K
G
D
L
Y
K
G
D
Q
L
L
G
N
I
Y
F
-
T
T
N
K
T
S
P
F
R
I
A
K
D
S
Y
L
W
M
S
Y
S
D
D
D
G
K
T
W
S
A
P
Q
D
I
T
P
M
V
K
A
D
W
M
K
F
L
G
V
G
P
G
T
G
I
V
L
R
N
G
P
H
K
G
R
I
L
I
P
V
Y
T
T
N
N
V
S
H
L
D
G
S
Q
S
S
R
V
I
Y
S
D
D
H
G
K
T
W
H
A
G
E
A
V
N
D
N
R
Q
V
-
D
G
Q
-
K
I
H
S
S
T
M
N
N
R
R
A
Q
N
T
E
S
T
V
V
Q
L
N
N
G
D
V
K
L
F
M
R
G
L
T
G
D
L
Q
V
A
T
S
K
D
G
G
V
T
W
E
K
D
I
K
R
Y
P
Q
V
K
D
V
Y
V
Q
M
S
A
I
H
T
--
M
H
--
E
G
K
E
Y
I
I
L
S
N
A
G
G
P
K
R
E
N
G
M
V
H
L
A
R
V
E
-----
E
N
G
----
E
L
-----
T
W
L
K
H
N
P
I
Q
K
G
E
F
A
Y
N
S
L
Q
E
L
G
N
G
E
Y
G
I
L
Y
E
H
T
E
K
G
Q
N
A
Y
T
L
S
F
R
K
F
N
W
E
F
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
25
PsiBlast_CBE
91.74
100%
-31
- C5 -
-
2W20
3
NANA_STRR6
B:
[2-470]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
L
T
E
K
T
D
I
F
E
S
G
R
N
G
K
P
N
K
D
G
I
K
S
Y
R
I
P
A
L
L
K
T
D
K
G
T
L
I
A
G
A
D
E
R
R
L
H
S
S
D
W
--
G
D
I
G
M
V
I
R
R
S
E
D
N
G
K
T
W
G
D
R
V
T
I
T
N
L
R
D
N
P
K
A
S
D
P
S
I
G
S
P
V
N
I
D
M
V
L
V
Q
D
P
E
T
K
R
I
F
S
I
Y
D
M
F
P
E
G
K
G
I
F
--
G
M
S
S
Q
K
E
E
A
Y
K
K
I
D
G
K
T
Y
Q
I
L
Y
R
E
G
E
K
G
A
Y
T
I
R
E
N
G
T
V
Y
T
P
D
G
K
A
T
D
Y
R
V
V
V
D
P
V
K
P
A
Y
S
D
K
G
D
L
Y
K
G
N
Q
L
L
G
N
I
Y
F
-
T
T
N
K
T
S
P
F
R
I
A
K
D
S
Y
L
W
M
S
Y
S
D
D
D
G
K
T
W
S
A
P
Q
D
I
T
P
M
V
K
A
D
W
M
K
F
L
G
V
G
P
G
T
G
I
V
L
R
N
G
P
H
K
G
R
I
L
I
P
V
Y
T
T
N
N
V
S
H
L
N
G
S
Q
S
S
R
I
I
Y
S
D
D
H
G
K
T
W
H
A
G
E
A
V
N
D
N
R
Q
V
-
D
G
Q
-
K
I
H
S
S
T
M
N
N
R
R
A
Q
N
T
E
S
T
V
V
Q
L
N
N
G
D
V
K
L
F
M
R
G
L
T
G
D
L
Q
V
A
T
S
K
D
G
G
V
T
W
E
K
D
I
K
R
Y
P
Q
V
K
D
V
Y
V
Q
M
S
A
I
H
T
--
M
H
--
E
G
K
E
Y
I
I
L
S
N
A
G
G
P
K
R
E
N
G
M
V
H
L
A
R
V
E
-----
E
N
G
----
E
L
-----
T
W
L
K
H
N
P
I
Q
K
G
E
F
A
Y
N
S
L
Q
E
L
G
N
G
E
Y
G
I
L
Y
E
H
T
E
K
G
Q
N
A
Y
T
L
S
F
R
K
F
N
W
D
F
L
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
PsiBlast_CBE
91.73
100%
-31
- C5 -
-
2VVZ
1
NANA_STREE
B:
[4-473]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
L
T
E
K
T
D
I
F
E
S
G
R
N
G
K
P
N
K
D
G
I
K
S
Y
R
I
P
A
L
L
K
T
D
K
G
T
L
I
A
G
A
D
E
R
R
L
H
S
S
D
W
--
G
D
I
G
M
V
I
R
R
S
E
D
N
G
K
T
W
G
D
R
V
T
I
T
N
L
R
D
N
P
K
A
S
D
P
S
I
G
S
P
V
N
I
D
M
V
L
V
Q
D
P
E
T
K
R
I
F
S
I
Y
D
M
F
P
E
G
K
G
I
F
--
G
M
S
S
Q
K
E
E
A
Y
K
K
I
D
G
K
T
Y
Q
I
L
Y
R
E
G
E
K
G
A
Y
T
I
R
E
N
G
T
V
Y
T
P
D
G
K
A
T
D
Y
R
V
V
V
D
P
V
K
P
A
Y
S
D
K
G
D
L
Y
K
G
N
Q
L
L
G
N
I
Y
F
-
T
T
N
K
T
S
P
F
R
I
A
K
D
S
Y
L
W
M
S
Y
S
D
D
D
G
K
T
W
S
A
P
Q
D
I
T
P
M
V
K
A
D
W
M
K
F
L
G
V
G
P
G
T
G
I
V
L
R
N
G
P
H
K
G
R
I
L
I
P
V
Y
T
T
N
N
V
S
H
L
N
G
S
Q
S
S
R
I
I
Y
S
D
D
H
G
K
T
W
H
A
G
E
A
V
N
D
N
R
Q
V
-
D
G
Q
-
K
I
H
S
S
T
M
N
N
R
R
A
Q
N
T
E
S
T
V
V
Q
L
N
N
G
D
V
K
L
F
M
R
G
L
T
G
D
L
Q
V
A
T
S
K
D
G
G
V
T
W
E
K
D
I
K
R
Y
P
Q
V
K
D
V
Y
V
Q
M
S
A
I
H
T
--
M
H
--
E
G
K
E
Y
I
I
L
S
N
A
G
G
P
K
R
E
N
G
M
V
H
L
A
R
V
E
-----
E
N
G
----
E
L
-----
T
W
L
K
H
N
P
I
Q
K
G
E
F
A
Y
N
S
L
Q
E
L
G
N
G
E
Y
G
I
L
Y
E
H
T
E
K
G
Q
N
A
Y
T
L
S
F
R
K
F
N
W
D
F
L
S
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
91.73
100%
-31
- C5 -
-
2VVZ
1
NANA_STREE
A:
[4-473]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
L
T
E
K
T
D
I
F
E
S
G
R
N
G
K
P
N
K
D
G
I
K
S
Y
R
I
P
A
L
L
K
T
D
K
G
T
L
I
A
G
A
D
E
R
R
L
H
S
S
D
W
--
G
D
I
G
M
V
I
R
R
S
E
D
N
G
K
T
W
G
D
R
V
T
I
T
N
L
R
D
N
P
K
A
S
D
P
S
I
G
S
P
V
N
I
D
M
V
L
V
Q
D
P
E
T
K
R
I
F
S
I
Y
D
M
F
P
E
G
K
G
I
F
--
G
M
S
S
Q
K
E
E
A
Y
K
K
I
D
G
K
T
Y
Q
I
L
Y
R
E
G
E
K
G
A
Y
T
I
R
E
N
G
T
V
Y
T
P
D
G
K
A
T
D
Y
R
V
V
V
D
P
V
K
P
A
Y
S
D
K
G
D
L
Y
K
G
N
Q
L
L
G
N
I
Y
F
-
T
T
N
K
T
S
P
F
R
I
A
K
D
S
Y
L
W
M
S
Y
S
D
D
D
G
K
T
W
S
A
P
Q
D
I
T
P
M
V
K
A
D
W
M
K
F
L
G
V
G
P
G
T
G
I
V
L
R
N
G
P
H
K
G
R
I
L
I
P
V
Y
T
T
N
N
V
S
H
L
N
G
S
Q
S
S
R
I
I
Y
S
D
D
H
G
K
T
W
H
A
G
E
A
V
N
D
N
R
Q
V
-
D
G
Q
-
K
I
H
S
S
T
M
N
N
R
R
A
Q
N
T
E
S
T
V
V
Q
L
N
N
G
D
V
K
L
F
M
R
G
L
T
G
D
L
Q
V
A
T
S
K
D
G
G
V
T
W
E
K
D
I
K
R
Y
P
Q
V
K
D
V
Y
V
Q
M
S
A
I
H
T
--
M
H
--
E
G
K
E
Y
I
I
L
S
N
A
G
G
P
K
R
E
N
G
M
V
H
L
A
R
V
E
-----
E
N
G
----
E
L
-----
T
W
L
K
H
N
P
I
Q
K
G
E
F
A
Y
N
S
L
Q
E
L
G
N
G
E
Y
G
I
L
Y
E
H
T
E
K
G
Q
N
A
Y
T
L
S
F
R
K
F
N
W
D
F
L
S
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
91.71
98%
-30
- C5 -
-
2YA6
4
NANA_STREE
A:
[23-492]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
L
T
E
K
T
D
I
F
E
S
G
R
N
G
N
P
N
K
D
G
I
K
S
Y
R
I
P
A
L
L
K
T
D
K
G
T
L
I
A
G
A
D
E
R
R
L
H
S
S
D
W
--
G
D
I
G
M
V
I
R
R
S
E
D
N
G
K
T
W
G
D
R
V
T
I
T
N
L
R
D
N
P
K
A
S
D
P
S
I
G
S
P
V
N
I
D
M
V
L
V
Q
D
P
E
T
K
R
I
F
S
I
Y
D
M
F
P
E
G
K
G
I
F
--
G
M
S
S
Q
K
E
E
A
Y
K
K
I
D
G
K
T
Y
Q
I
L
Y
R
E
G
E
K
G
A
Y
T
I
R
E
N
G
T
V
Y
T
P
D
G
K
A
T
D
Y
R
V
V
V
D
P
V
K
P
A
Y
S
D
K
G
D
L
Y
K
G
D
Q
L
L
G
N
I
Y
F
-
T
T
N
K
T
S
P
F
R
I
A
K
D
S
Y
L
W
M
S
Y
S
D
D
D
G
K
T
W
S
A
P
Q
D
I
T
P
M
V
K
A
D
W
M
K
F
L
G
V
G
P
G
T
G
I
V
L
R
N
G
P
H
K
G
R
I
L
I
P
V
Y
T
T
N
N
V
S
H
L
D
G
S
Q
S
S
R
V
I
Y
S
D
D
H
G
K
T
W
H
A
G
E
A
V
N
D
N
R
Q
V
-
D
G
Q
-
K
I
H
S
S
T
M
N
N
R
R
A
Q
N
T
E
S
T
V
V
Q
L
N
N
G
D
V
K
L
F
M
R
G
L
T
G
D
L
Q
V
A
T
S
K
D
G
G
V
T
W
E
K
D
I
K
R
Y
P
Q
V
K
D
V
Y
V
Q
M
S
A
I
H
T
--
M
H
--
E
G
K
E
Y
I
I
L
S
N
A
G
G
P
K
R
E
N
G
M
V
H
L
A
R
V
E
-----
E
N
G
----
E
L
-----
T
W
L
K
H
N
P
I
Q
K
G
E
F
A
Y
N
S
L
Q
E
L
G
N
G
E
Y
G
I
L
Y
E
H
T
E
K
G
Q
N
A
Y
T
L
S
F
R
K
F
N
W
E
F
L
S
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
91.66
98%
-29
- C5 -
-
2YA5
4
NANA_STREE
A:
[23-493]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
L
T
E
K
T
D
I
F
E
S
G
R
N
G
N
P
N
K
D
G
I
K
S
Y
R
I
P
A
L
L
K
T
D
K
G
T
L
I
A
G
A
D
E
R
R
L
H
S
S
D
W
--
G
D
I
G
M
V
I
R
R
S
E
D
N
G
K
T
W
G
D
R
V
T
I
T
N
L
R
D
N
P
K
A
S
D
P
S
I
G
S
P
V
N
I
D
M
V
L
V
Q
D
P
E
T
K
R
I
F
S
I
Y
D
M
F
P
E
G
K
G
I
F
--
G
M
S
S
Q
K
E
E
A
Y
K
K
I
D
G
K
T
Y
Q
I
L
Y
R
E
G
E
K
G
A
Y
T
I
R
E
N
G
T
V
Y
T
P
D
G
K
A
T
D
Y
R
V
V
V
D
P
V
K
P
A
Y
S
D
K
G
D
L
Y
K
G
D
Q
L
L
G
N
I
Y
F
-
T
T
N
K
T
S
P
F
R
I
A
K
D
S
Y
L
W
M
S
Y
S
D
D
D
G
K
T
W
S
A
P
Q
D
I
T
P
M
V
K
A
D
W
M
K
F
L
G
V
G
P
G
T
G
I
V
L
R
N
G
P
H
K
G
R
I
L
I
P
V
Y
T
T
N
N
V
S
H
L
D
G
S
Q
S
S
R
V
I
Y
S
D
D
H
G
K
T
W
H
A
G
E
A
V
N
D
N
R
Q
V
-
D
G
Q
-
K
I
H
S
S
T
M
N
N
R
R
A
Q
N
T
E
S
T
V
V
Q
L
N
N
G
D
V
K
L
F
M
R
G
L
T
G
D
L
Q
V
A
T
S
K
D
G
G
V
T
W
E
K
D
I
K
R
Y
P
Q
V
K
D
V
Y
V
Q
M
S
A
I
H
T
--
M
H
--
E
G
K
E
Y
I
I
L
S
N
A
G
G
P
K
R
E
N
G
M
V
H
L
A
R
V
E
-----
E
N
G
----
E
L
-----
T
W
L
K
H
N
P
I
Q
K
G
E
F
A
Y
N
S
L
Q
E
L
G
N
G
E
Y
G
I
L
Y
E
H
T
E
K
G
Q
N
A
Y
T
L
S
F
R
K
F
N
W
E
F
L
S
K
N
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
31
PsiBlast_CBE
91.65
98%
-31
- C5 -
-
2YA5
3
NANA_STREE
B:
[23-492]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
L
T
E
K
T
D
I
F
E
S
G
R
N
G
N
P
N
K
D
G
I
K
S
Y
R
I
P
A
L
L
K
T
D
K
G
T
L
I
A
G
A
D
E
R
R
L
H
S
S
D
W
--
G
D
I
G
M
V
I
R
R
S
E
D
N
G
K
T
W
G
D
R
V
T
I
T
N
L
R
D
N
P
K
A
S
D
P
S
I
G
S
P
V
N
I
D
M
V
L
V
Q
D
P
E
T
K
R
I
F
S
I
Y
D
M
F
P
E
G
K
G
I
F
--
G
M
S
S
Q
K
E
E
A
Y
K
K
I
D
G
K
T
Y
Q
I
L
Y
R
E
G
E
K
G
A
Y
T
I
R
E
N
G
T
V
Y
T
P
D
G
K
A
T
D
Y
R
V
V
V
D
P
V
K
P
A
Y
S
D
K
G
D
L
Y
K
G
D
Q
L
L
G
N
I
Y
F
-
T
T
N
K
T
S
P
F
R
I
A
K
D
S
Y
L
W
M
S
Y
S
D
D
D
G
K
T
W
S
A
P
Q
D
I
T
P
M
V
K
A
D
W
M
K
F
L
G
V
G
P
G
T
G
I
V
L
R
N
G
P
H
K
G
R
I
L
I
P
V
Y
T
T
N
N
V
S
H
L
D
G
S
Q
S
S
R
V
I
Y
S
D
D
H
G
K
T
W
H
A
G
E
A
V
N
D
N
R
Q
V
-
D
G
Q
-
K
I
H
S
S
T
M
N
N
R
R
A
Q
N
T
E
S
T
V
V
Q
L
N
N
G
D
V
K
L
F
M
R
G
L
T
G
D
L
Q
V
A
T
S
K
D
G
G
V
T
W
E
K
D
I
K
R
Y
P
Q
V
K
D
V
Y
V
Q
M
S
A
I
H
T
--
M
H
--
E
G
K
E
Y
I
I
L
S
N
A
G
G
P
K
R
E
N
G
M
V
H
L
A
R
V
E
-----
E
N
G
----
E
L
-----
T
W
L
K
H
N
P
I
Q
K
G
E
F
A
Y
N
S
L
Q
E
L
G
N
G
E
Y
G
I
L
Y
E
H
T
E
K
G
Q
N
A
Y
T
L
S
F
R
K
F
N
W
E
F
L
S
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
28
PsiBlast_CBE
91.57
98%
-29
- C5 -
-
2YA7
1
NANA_STREE
C:
[23-492]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
L
T
E
K
T
D
I
F
E
S
G
R
N
G
N
P
N
K
D
G
I
K
S
Y
R
I
P
A
L
L
K
T
D
K
G
T
L
I
A
G
A
D
E
R
R
L
H
S
S
D
W
--
G
D
I
G
M
V
I
R
R
S
E
D
N
G
K
T
W
G
D
R
V
T
I
T
N
L
R
D
N
P
K
A
S
D
P
S
I
G
S
P
V
N
I
D
M
V
L
V
Q
D
P
E
T
K
R
I
F
S
I
Y
D
M
F
P
E
G
K
G
I
F
--
G
M
S
S
Q
K
E
E
A
Y
K
K
I
D
G
K
T
Y
Q
I
L
Y
R
E
G
E
K
G
A
Y
T
I
R
E
N
G
T
V
Y
T
P
D
G
K
A
T
D
Y
R
V
V
V
D
P
V
K
P
A
Y
S
D
K
G
D
L
Y
K
G
D
Q
L
L
G
N
I
Y
F
-
T
T
N
K
T
S
P
F
R
I
A
K
D
S
Y
L
W
M
S
Y
S
D
D
D
G
K
T
W
S
A
P
Q
D
I
T
P
M
V
K
A
D
W
M
K
F
L
G
V
G
P
G
T
G
I
V
L
R
N
G
P
H
K
G
R
I
L
I
P
V
Y
T
T
N
N
V
S
H
L
D
G
S
Q
S
S
R
V
I
Y
S
D
D
H
G
K
T
W
H
A
G
E
A
V
N
D
N
R
Q
V
-
D
G
Q
-
K
I
H
S
S
T
M
N
N
R
R
A
Q
N
T
E
S
T
V
V
Q
L
N
N
G
D
V
K
L
F
M
R
G
L
T
G
D
L
Q
V
A
T
S
K
D
G
G
V
T
W
E
K
D
I
K
R
Y
P
Q
V
K
D
V
Y
V
Q
M
S
A
I
H
T
--
M
H
--
E
G
K
E
Y
I
I
L
S
N
A
G
G
P
K
R
E
N
G
M
V
H
L
A
R
V
E
-----
E
N
G
----
E
L
-----
T
W
L
K
H
N
P
I
Q
K
G
E
F
A
Y
N
S
L
Q
E
L
G
N
G
E
Y
G
I
L
Y
E
H
T
E
K
G
Q
N
A
Y
T
L
S
F
R
K
F
N
W
E
F
L
S
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
27
PsiBlast_CBE
91.57
98%
-31
- C5 -
-
2YA7
1
NANA_STREE
D:
[23-492]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
L
T
E
K
T
D
I
F
E
S
G
R
N
G
N
P
N
K
D
G
I
K
S
Y
R
I
P
A
L
L
K
T
D
K
G
T
L
I
A
G
A
D
E
R
R
L
H
S
S
D
W
--
G
D
I
G
M
V
I
R
R
S
E
D
N
G
K
T
W
G
D
R
V
T
I
T
N
L
R
D
N
P
K
A
S
D
P
S
I
G
S
P
V
N
I
D
M
V
L
V
Q
D
P
E
T
K
R
I
F
S
I
Y
D
M
F
P
E
G
K
G
I
F
--
G
M
S
S
Q
K
E
E
A
Y
K
K
I
D
G
K
T
Y
Q
I
L
Y
R
E
G
E
K
G
A
Y
T
I
R
E
N
G
T
V
Y
T
P
D
G
K
A
T
D
Y
R
V
V
V
D
P
V
K
P
A
Y
S
D
K
G
D
L
Y
K
G
D
Q
L
L
G
N
I
Y
F
-
T
T
N
K
T
S
P
F
R
I
A
K
D
S
Y
L
W
M
S
Y
S
D
D
D
G
K
T
W
S
A
P
Q
D
I
T
P
M
V
K
A
D
W
M
K
F
L
G
V
G
P
G
T
G
I
V
L
R
N
G
P
H
K
G
R
I
L
I
P
V
Y
T
T
N
N
V
S
H
L
D
G
S
Q
S
S
R
V
I
Y
S
D
D
H
G
K
T
W
H
A
G
E
A
V
N
D
N
R
Q
V
-
D
G
Q
-
K
I
H
S
S
T
M
N
N
R
R
A
Q
N
T
E
S
T
V
V
Q
L
N
N
G
D
V
K
L
F
M
R
G
L
T
G
D
L
Q
V
A
T
S
K
D
G
G
V
T
W
E
K
D
I
K
R
Y
P
Q
V
K
D
V
Y
V
Q
M
S
A
I
H
T
--
M
H
--
E
G
K
E
Y
I
I
L
S
N
A
G
G
P
K
R
E
N
G
M
V
H
L
A
R
V
E
-----
E
N
G
----
E
L
-----
T
W
L
K
H
N
P
I
Q
K
G
E
F
A
Y
N
S
L
Q
E
L
G
N
G
E
Y
G
I
L
Y
E
H
T
E
K
G
Q
N
A
Y
T
L
S
F
R
K
F
N
W
E
F
L
S
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
91.54
98%
-29
- C5 -
-
2YA8
5
NANA_STREE
A:
[23-492]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
L
T
E
K
T
D
I
F
E
S
G
R
N
G
N
P
N
K
D
G
I
K
S
Y
R
I
P
A
L
L
K
T
D
K
G
T
L
I
A
G
A
D
E
R
R
L
H
S
S
D
W
--
G
D
I
G
M
V
I
R
R
S
E
D
N
G
K
T
W
G
D
R
V
T
I
T
N
L
R
D
N
P
K
A
S
D
P
S
I
G
S
P
V
N
I
D
M
V
L
V
Q
D
P
E
T
K
R
I
F
S
I
Y
D
M
F
P
E
G
K
G
I
F
--
G
M
S
S
Q
K
E
E
A
Y
K
K
I
D
G
K
T
Y
Q
I
L
Y
R
E
G
E
K
G
A
Y
T
I
R
E
N
G
T
V
Y
T
P
D
G
K
A
T
D
Y
R
V
V
V
D
P
V
K
P
A
Y
S
D
K
G
D
L
Y
K
G
D
Q
L
L
G
N
I
Y
F
-
T
T
N
K
T
S
P
F
R
I
A
K
D
S
Y
L
W
M
S
Y
S
D
D
D
G
K
T
W
S
A
P
Q
D
I
T
P
M
V
K
A
D
W
M
K
F
L
G
V
G
P
G
T
G
I
V
L
R
N
G
P
H
K
G
R
I
L
I
P
V
Y
T
T
N
N
V
S
H
L
D
G
S
Q
S
S
R
V
I
Y
S
D
D
H
G
K
T
W
H
A
G
E
A
V
N
D
N
R
Q
V
-
D
G
Q
-
K
I
H
S
S
T
M
N
N
R
R
A
Q
N
T
E
S
T
V
V
Q
L
N
N
G
D
V
K
L
F
M
R
G
L
T
G
D
L
Q
V
A
T
S
K
D
G
G
V
T
W
E
K
D
I
K
R
Y
P
Q
V
K
D
V
Y
V
Q
M
S
A
I
H
T
--
M
H
--
E
G
K
E
Y
I
I
L
S
N
A
G
G
P
K
R
E
N
G
M
V
H
L
A
R
V
E
-----
E
N
G
----
E
L
-----
T
W
L
K
H
N
P
I
Q
K
G
E
F
A
Y
N
S
L
Q
E
L
G
N
G
E
Y
G
I
L
Y
E
H
T
E
K
G
Q
N
A
Y
T
L
S
F
R
K
F
N
W
E
F
L
S
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
91.41
98%
-28
- C5 -
-
2YA4
9
NANA_STREE
A:
[23-492]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
L
T
E
K
T
D
I
F
E
S
G
R
N
G
N
P
N
K
D
G
I
K
S
Y
R
I
P
A
L
L
K
T
D
K
G
T
L
I
A
G
A
D
E
R
R
L
H
S
S
D
W
--
G
D
I
G
M
V
I
R
R
S
E
D
N
G
K
T
W
G
D
R
V
T
I
T
N
L
R
D
N
P
K
A
S
D
P
S
I
G
S
P
V
N
I
D
M
V
L
V
Q
D
P
E
T
K
R
I
F
S
I
Y
D
M
F
P
E
G
K
G
I
F
--
G
M
S
S
Q
K
E
E
A
Y
K
K
I
D
G
K
T
Y
Q
I
L
Y
R
E
G
E
K
G
A
Y
T
I
R
E
N
G
T
V
Y
T
P
D
G
K
A
T
D
Y
R
V
V
V
D
P
V
K
P
A
Y
S
D
K
G
D
L
Y
K
G
D
Q
L
L
G
N
I
Y
F
-
T
T
N
K
T
S
P
F
R
I
A
K
D
S
Y
L
W
M
S
Y
S
D
D
D
G
K
T
W
S
A
P
Q
D
I
T
P
M
V
K
A
D
W
M
K
F
L
G
V
G
P
G
T
G
I
V
L
R
N
G
P
H
K
G
R
I
L
I
P
V
Y
T
T
N
N
V
S
H
L
D
G
S
Q
S
S
R
V
I
Y
S
D
D
H
G
K
T
W
H
A
G
E
A
V
N
D
N
R
Q
V
-
D
G
Q
-
K
I
H
S
S
T
M
N
N
R
R
A
Q
N
T
E
S
T
V
V
Q
L
N
N
G
D
V
K
L
F
M
R
G
L
T
G
D
L
Q
V
A
T
S
K
D
G
G
V
T
W
E
K
D
I
K
R
Y
P
Q
V
K
D
V
Y
V
Q
M
S
A
I
H
T
--
M
H
--
E
G
K
E
Y
I
I
L
S
N
A
G
G
P
K
R
E
N
G
M
V
H
L
A
R
V
E
-----
E
N
G
----
E
L
-----
T
W
L
K
H
N
P
I
Q
K
G
E
F
A
Y
N
S
L
Q
E
L
G
N
G
E
Y
G
I
L
Y
E
H
T
E
K
G
Q
N
A
Y
T
L
S
F
R
K
F
N
W
E
F
L
S
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
26
PsiBlast_CBE
91.13
98%
-29
- C5 -
-
2YA8
5
NANA_STREE
B:
[23-492]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
L
T
E
K
T
D
I
F
E
S
G
R
N
G
N
P
N
K
D
G
I
K
S
Y
R
I
P
A
L
L
K
T
D
K
G
T
L
I
A
G
A
D
E
R
R
L
H
S
S
D
W
--
G
D
I
G
M
V
I
R
R
S
E
D
N
G
K
T
W
G
D
R
V
T
I
T
N
L
R
D
N
P
K
A
S
D
P
S
I
G
S
P
V
N
I
D
M
V
L
V
Q
D
P
E
T
K
R
I
F
S
I
Y
D
M
F
P
E
G
K
G
I
F
--
G
M
S
S
Q
K
E
E
A
Y
K
K
I
D
G
K
T
Y
Q
I
L
Y
R
E
G
E
K
G
A
Y
T
I
R
E
N
G
T
V
Y
T
P
D
G
K
A
T
D
Y
R
V
V
V
D
P
V
K
P
A
Y
S
D
K
G
D
L
Y
K
G
D
Q
L
L
G
N
I
Y
F
-
T
T
N
K
T
S
P
F
R
I
A
K
D
S
Y
L
W
M
S
Y
S
D
D
D
G
K
T
W
S
A
P
Q
D
I
T
P
M
V
K
A
D
W
M
K
F
L
G
V
G
P
G
T
G
I
V
L
R
N
G
P
H
K
G
R
I
L
I
P
V
Y
T
T
N
N
V
S
H
L
D
G
S
Q
S
S
R
V
I
Y
S
D
D
H
G
K
T
W
H
A
G
E
A
V
N
D
N
R
Q
V
-
D
G
Q
-
K
I
H
S
S
T
M
N
N
R
R
A
Q
N
T
E
S
T
V
V
Q
L
N
N
G
D
V
K
L
F
M
R
G
L
T
G
D
L
Q
V
A
T
S
K
D
G
G
V
T
W
E
K
D
I
K
R
Y
P
Q
V
K
D
V
Y
V
Q
M
S
A
I
H
T
--
M
H
--
E
G
K
E
Y
I
I
L
S
N
A
G
G
P
K
R
E
N
G
M
V
H
L
A
R
V
E
-----
E
N
G
----
E
L
-----
T
W
L
K
H
N
P
I
Q
K
G
E
F
A
Y
N
S
L
Q
E
L
G
N
G
E
Y
G
I
L
Y
E
H
T
E
K
G
Q
N
A
Y
T
L
S
F
R
K
F
N
W
E
F
L
S
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
32
PsiBlast_CBE
90.99
98%
-30
- C5 -
-
2YA4
8
NANA_STREE
B:
[23-493]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
L
T
E
K
T
D
I
F
E
S
G
R
N
G
N
P
N
K
D
G
I
K
S
Y
R
I
P
A
L
L
K
T
D
K
G
T
L
I
A
G
A
D
E
R
R
L
H
S
S
D
W
--
G
D
I
G
M
V
I
R
R
S
E
D
N
G
K
T
W
G
D
R
V
T
I
T
N
L
R
D
N
P
K
A
S
D
P
S
I
G
S
P
V
N
I
D
M
V
L
V
Q
D
P
E
T
K
R
I
F
S
I
Y
D
M
F
P
E
G
K
G
I
F
--
G
M
S
S
Q
K
E
E
A
Y
K
K
I
D
G
K
T
Y
Q
I
L
Y
R
E
G
E
K
G
A
Y
T
I
R
E
N
G
T
V
Y
T
P
D
G
K
A
T
D
Y
R
V
V
V
D
P
V
K
P
A
Y
S
D
K
G
D
L
Y
K
G
D
Q
L
L
G
N
I
Y
F
-
T
T
N
K
T
S
P
F
R
I
A
K
D
S
Y
L
W
M
S
Y
S
D
D
D
G
K
T
W
S
A
P
Q
D
I
T
P
M
V
K
A
D
W
M
K
F
L
G
V
G
P
G
T
G
I
V
L
R
N
G
P
H
K
G
R
I
L
I
P
V
Y
T
T
N
N
V
S
H
L
D
G
S
Q
S
S
R
V
I
Y
S
D
D
H
G
K
T
W
H
A
G
E
A
V
N
D
N
R
Q
V
-
D
G
Q
-
K
I
H
S
S
T
M
N
N
R
R
A
Q
N
T
E
S
T
V
V
Q
L
N
N
G
D
V
K
L
F
M
R
G
L
T
G
D
L
Q
V
A
T
S
K
D
G
G
V
T
W
E
K
D
I
K
R
Y
P
Q
V
K
D
V
Y
V
Q
M
S
A
I
H
T
--
M
H
--
E
G
K
E
Y
I
I
L
S
N
A
G
G
P
K
R
E
N
G
M
V
H
L
A
R
V
E
-----
E
N
G
----
E
L
-----
T
W
L
K
H
N
P
I
Q
K
G
E
F
A
Y
N
S
L
Q
E
L
G
N
G
E
Y
G
I
L
Y
E
H
T
E
K
G
Q
N
A
Y
T
L
S
F
R
K
F
N
W
E
F
L
S
K
N
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
30
PsiBlast_CBE
90.38
98%
-28
- C5 -
-
2YA6
3
NANA_STREE
B:
[23-492]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
L
T
E
K
T
D
I
F
E
S
G
R
N
G
N
P
N
K
D
G
I
K
S
Y
R
I
P
A
L
L
K
T
D
K
G
T
L
I
A
G
A
D
E
R
R
L
H
S
S
D
W
--
G
D
I
G
M
V
I
R
R
S
E
D
N
G
K
T
W
G
D
R
V
T
I
T
N
L
R
D
N
P
K
A
S
D
P
S
I
G
S
P
V
N
I
D
M
V
L
V
Q
D
P
E
T
K
R
I
F
S
I
Y
D
M
F
P
E
G
K
G
I
F
--
G
M
S
S
Q
K
E
E
A
Y
K
K
I
D
G
K
T
Y
Q
I
L
Y
R
E
G
E
K
G
A
Y
T
I
R
E
N
G
T
V
Y
T
P
D
G
K
A
T
D
Y
R
V
V
V
D
P
V
K
P
A
Y
S
D
K
G
D
L
Y
K
G
D
Q
L
L
G
N
I
Y
F
-
T
T
N
K
T
S
P
F
R
I
A
K
D
S
Y
L
W
M
S
Y
S
D
D
D
G
K
T
W
S
A
P
Q
D
I
T
P
M
V
K
A
D
W
M
K
F
L
G
V
G
P
G
T
G
I
V
L
R
N
G
P
H
K
G
R
I
L
I
P
V
Y
T
T
N
N
V
S
H
L
D
G
S
Q
S
S
R
V
I
Y
S
D
D
H
G
K
T
W
H
A
G
E
A
V
N
D
N
R
Q
V
-
D
G
Q
-
K
I
H
S
S
T
M
N
N
R
R
A
Q
N
T
E
S
T
V
V
Q
L
N
N
G
D
V
K
L
F
M
R
G
L
T
G
D
L
Q
V
A
T
S
K
D
G
G
V
T
W
E
K
D
I
K
R
Y
P
Q
V
K
D
V
Y
V
Q
M
S
A
I
H
T
--
M
H
--
E
G
K
E
Y
I
I
L
S
N
A
G
G
P
K
R
E
N
G
M
V
H
L
A
R
V
E
-----
E
N
G
----
E
L
-----
T
W
L
K
H
N
P
I
Q
K
G
E
F
A
Y
N
S
L
Q
E
L
G
N
G
E
Y
G
I
L
Y
E
H
T
E
K
G
Q
N
A
Y
T
L
S
F
R
K
F
N
W
E
F
L
S
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
56.93
41%
80
- C5 -
-
2VK6
2
?
A:
[2-438]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
G
A
V
K
T
E
P
V
D
L
F
H
P
G
F
L
N
S
S
N
------
Y
R
I
P
A
L
F
K
T
K
E
G
T
L
I
A
S
I
D
A
R
R
H
G
G
A
D
A
PN
N
D
I
D
T
A
V
R
R
S
E
D
G
G
K
T
W
D
E
G
Q
I
I
M
D
Y
P
D
K
S
S
V
----------
I
D
T
T
L
I
Q
D
D
E
T
G
R
I
F
L
L
V
T
H
F
P
S
K
Y
G
F
W
NA
G
L
G
S
----
G
F
K
N
I
D
G
K
E
Y
L
C
L
Y
D
S
S
G
K
-
E
F
T
V
R
E
N
-
V
V
Y
D
K
D
S
N
K
T
E
Y
T
T
---------
N
A
L
G
D
L
F
K
N
G
T
K
I
D
N
I
----
N
S
S
T
A
P
L
K
A
K
G
T
S
Y
I
N
L
V
Y
S
D
D
D
G
K
T
W
S
E
P
Q
N
I
N
F
Q
V
K
K
D
W
M
K
F
L
G
I
A
P
G
R
G
I
Q
I
K
N
G
E
H
K
G
R
I
V
V
P
V
Y
Y
T
N
E
----
K
G
K
Q
S
S
A
V
I
Y
S
D
D
S
G
K
N
W
T
I
G
E
S
P
N
D
N
R
K
L
E
N
G
K
-
I
I
N
S
K
T
L
S
D
D
A
P
Q
L
T
E
C
Q
V
V
E
M
P
N
G
Q
L
K
L
F
M
R
N
L
S
G
Y
L
N
I
A
T
S
F
D
G
G
A
T
W
D
E
T
V
E
K
D
T
N
V
L
E
P
Y
C
Q
L
S
V
I
N
Y
--
S
Q
KV
D
G
K
D
A
V
I
F
S
N
P
N
A
R
S
R
S
N
G
T
V
R
I
G
L
I
N
QVGTY
E
N
G
E
P
K
Y
E
F
-----
D
W
K
Y
N
K
L
V
K
P
G
Y
Y
A
Y
S
C
L
T
E
L
S
N
G
N
I
G
L
L
Y
E
G
T
P
S
E
E
M
S
Y
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
34
PsiBlast_CBE
56.91
41%
78
- C5 -
-
2VK7
1
?
B:
[2-438]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
G
A
V
K
T
E
P
V
D
L
F
H
P
G
F
L
N
S
S
N
------
Y
R
I
P
A
L
F
K
T
K
E
G
T
L
I
A
S
I
D
A
R
R
H
G
G
A
D
A
PN
N
D
I
D
T
A
V
R
R
S
E
D
G
G
K
T
W
D
E
G
Q
I
I
M
D
Y
P
D
K
S
S
V
----------
I
D
T
T
L
I
Q
D
D
E
T
G
R
I
F
L
L
V
T
H
F
P
S
K
Y
G
F
W
NA
G
L
G
S
----
G
F
K
N
I
D
G
K
E
Y
L
C
L
Y
D
S
S
G
K
-
E
F
T
V
R
E
N
-
V
V
Y
D
K
D
S
N
K
T
E
Y
T
T
---------
N
A
L
G
D
L
F
K
N
G
T
K
I
D
N
I
----
N
S
S
T
A
P
L
K
A
K
G
T
S
Y
I
N
L
V
Y
S
D
D
D
G
K
T
W
S
E
P
Q
N
I
N
F
Q
V
K
K
D
W
M
K
F
L
G
I
A
P
G
R
G
I
Q
I
K
N
G
E
H
K
G
R
I
V
V
P
V
Y
Y
T
N
E
----
K
G
K
Q
S
S
A
V
I
Y
S
D
D
S
G
K
N
W
T
I
G
E
S
P
N
D
N
R
K
L
E
N
G
K
-
I
I
N
S
K
T
L
S
D
D
A
P
Q
L
T
E
C
Q
V
V
E
M
P
N
G
Q
L
K
L
F
M
R
N
L
S
G
Y
L
N
I
A
T
S
F
D
G
G
A
T
W
D
E
T
V
E
K
D
T
N
V
L
E
P
Y
C
Q
L
S
V
I
N
Y
--
S
Q
KV
D
G
K
D
A
V
I
F
S
N
P
N
A
R
S
R
S
N
G
T
V
R
I
G
L
I
N
QVGTY
E
N
G
EPKY
E
F
-----
D
W
K
Y
N
K
L
V
K
P
G
Y
Y
A
Y
S
C
L
T
E
L
S
N
G
N
I
G
L
L
Y
E
G
T
P
S
E
E
M
S
Y
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
91
HHSearch
56.59
41%
50
- C5 -
-
2BF6
3
?
A:
[1-448]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
E
G
A
V
K
T
E
P
V
D
L
F
H
P
G
------
F
L
N
S
S
N
Y
R
I
P
A
L
F
K
T
K
E
G
T
L
I
A
S
I
D
A
R
R
H
G
G
A
D
A
PN
N
D
I
D
T
A
V
R
R
S
E
D
G
G
K
T
W
D
E
G
Q
I
I
M
D
Y
P
D
----------
K
S
S
V
I
D
T
T
L
I
Q
D
D
E
T
G
R
I
F
L
L
V
T
H
F
P
S
K
Y
G
F
W
--
N
A
G
L
--
G
S
G
F
K
----------
N
I
D
G
K
E
Y
L
C
L
Y
D
S
S
G
K
E
F
T
V
R
E
N
V
V
Y
-
D
K
D
S
N
K
T
E
Y
T
T
N
A
L
G
D
L
F
K
N
----
G
T
K
I
D
N
I
N
S
S
T
A
P
L
K
A
K
G
T
S
Y
I
N
L
V
Y
S
D
D
D
G
K
T
W
S
E
P
Q
N
I
N
F
Q
V
K
K
D
W
M
K
F
L
G
I
A
P
G
R
G
I
Q
I
K
N
G
E
H
K
G
R
I
V
V
P
V
Y
Y
T
N
E
----
K
G
K
Q
S
S
A
V
I
Y
S
D
D
S
G
K
N
W
T
I
G
E
S
P
N
D
N
R
K
L
-
E
N
G
K
I
I
N
S
K
T
L
S
D
D
A
P
Q
L
T
E
C
Q
V
V
E
M
P
N
G
Q
L
K
L
F
M
R
N
L
S
G
Y
L
N
I
A
T
S
F
D
G
G
A
T
W
D
E
T
V
E
K
D
T
N
V
L
E
P
Y
C
Q
L
S
V
I
N
Y
SQ
K
V
--
D
G
K
D
A
V
I
F
S
N
P
N
A
R
S
R
S
N
G
T
V
R
I
G
-
L
I
N
Q
VGT
Y
E
N
----
G
E
P
K
Y
E
F
D
W
K
Y
N
K
L
V
K
P
G
Y
Y
A
Y
S
C
L
T
E
L
S
N
G
N
I
G
L
L
Y
E
G
T
P
----
S
E
E
M
S
Y
I
E
M
N
L
K
Y
L
E
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
56.51
41%
77
- C5 -
-
2BF6
3
?
A:
[2-438]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
G
A
V
K
T
E
P
V
D
L
F
H
P
G
F
L
N
S
S
N
------
Y
R
I
P
A
L
F
K
T
K
E
G
T
L
I
A
S
I
D
A
R
R
H
G
G
A
D
A
PN
N
D
I
D
T
A
V
R
R
S
E
D
G
G
K
T
W
D
E
G
Q
I
I
M
D
Y
P
D
K
S
S
V
----------
I
D
T
T
L
I
Q
D
D
E
T
G
R
I
F
L
L
V
T
H
F
P
S
K
Y
G
F
W
NA
G
L
G
S
----
G
F
K
N
I
D
G
K
E
Y
L
C
L
Y
D
S
S
G
K
-
E
F
T
V
R
E
N
-
V
V
Y
D
K
D
S
N
K
T
E
Y
T
T
---------
N
A
L
G
D
L
F
K
N
G
T
K
I
D
N
I
----
N
S
S
T
A
P
L
K
A
K
G
T
S
Y
I
N
L
V
Y
S
D
D
D
G
K
T
W
S
E
P
Q
N
I
N
F
Q
V
K
K
D
W
M
K
F
L
G
I
A
P
G
R
G
I
Q
I
K
N
G
E
H
K
G
R
I
V
V
P
V
Y
Y
T
N
E
----
K
G
K
Q
S
S
A
V
I
Y
S
D
D
S
G
K
N
W
T
I
G
E
S
P
N
D
N
R
K
L
E
N
G
K
-
I
I
N
S
K
T
L
S
D
D
A
P
Q
L
T
E
C
Q
V
V
E
M
P
N
G
Q
L
K
L
F
M
R
N
L
S
G
Y
L
N
I
A
T
S
F
D
G
G
A
T
W
D
E
T
V
E
K
D
T
N
V
L
E
P
Y
C
Q
L
S
V
I
N
Y
--
S
Q
KV
D
G
K
D
A
V
I
F
S
N
P
N
A
R
S
R
S
N
G
T
V
R
I
G
L
I
N
Q
VGTY
E
N
G
E
P
K
Y
E
F
-----
D
W
K
Y
N
K
L
V
K
P
G
Y
Y
A
Y
S
C
L
T
E
L
S
N
G
N
I
G
L
L
Y
E
G
T
P
S
E
E
M
S
Y
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
55.58
41%
78
- C5 -
-
2VK7
1
?
A:
[2-438]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
G
A
V
K
T
E
P
V
D
L
F
H
P
G
F
L
N
S
S
N
------
Y
R
I
P
A
L
F
K
T
K
E
G
T
L
I
A
S
I
D
A
R
R
H
G
G
A
D
A
PN
N
D
I
D
T
A
V
R
R
S
E
D
G
G
K
T
W
D
E
G
Q
I
I
M
D
Y
P
D
K
S
S
V
----------
I
D
T
T
L
I
Q
D
D
E
T
G
R
I
F
L
L
V
T
H
F
P
S
K
Y
G
F
W
NA
G
L
G
S
----
G
F
K
N
I
D
G
K
E
Y
L
C
L
Y
D
S
S
G
K
-
E
F
T
V
R
E
N
-
V
V
Y
D
K
D
S
N
K
T
E
Y
T
T
---------
N
A
L
G
D
L
F
K
N
G
T
K
I
D
N
I
----
N
S
S
T
A
P
L
K
A
K
G
T
S
Y
I
N
L
V
Y
S
D
D
D
G
K
T
W
S
E
P
Q
N
I
N
F
Q
V
K
K
D
W
M
K
F
L
G
I
A
P
G
R
G
I
Q
I
K
N
G
E
H
K
G
R
I
V
V
P
V
Y
Y
T
N
E
----
K
G
K
Q
S
S
A
V
I
Y
S
D
D
S
G
K
N
W
T
I
G
E
S
P
N
D
N
R
K
L
E
N
G
K
-
I
I
N
S
K
T
L
S
D
D
A
P
Q
L
T
E
C
Q
V
V
E
M
P
N
G
Q
L
K
L
F
M
R
N
L
S
G
Y
L
N
I
A
T
S
F
D
G
G
A
T
W
D
E
T
V
E
K
D
T
N
V
L
E
P
Y
C
Q
L
S
V
I
N
Y
--
S
Q
KV
D
G
K
D
A
V
I
F
S
N
P
N
A
R
S
R
S
N
G
T
V
R
I
G
L
I
N
Q
VGTY
E
N
G
E
P
K
Y
E
F
-----
D
W
K
Y
N
K
L
V
K
P
G
Y
Y
A
Y
S
C
L
T
E
L
S
N
G
N
I
G
L
L
Y
E
G
T
P
S
E
E
M
S
Y
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
55.52
41%
78
- C5 -
-
5TSP
1
?
A:
[2-439]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
E
G
A
V
K
T
E
P
V
D
L
F
H
P
G
F
L
N
S
S
N
------
Y
R
I
P
A
L
F
K
T
K
E
G
T
L
I
A
S
I
D
A
R
R
Q
G
G
A
D
A
PN
N
D
I
D
T
A
V
R
R
S
E
D
G
G
K
T
W
D
E
G
Q
I
I
M
D
Y
P
D
K
S
S
V
----------
I
D
T
T
L
I
Q
D
D
E
T
G
R
I
F
L
L
V
T
H
F
P
S
K
Y
G
F
W
NA
G
L
G
S
----
G
F
K
N
I
D
G
K
E
Y
L
C
L
Y
D
S
S
G
K
-
E
F
T
V
R
E
N
-
V
V
Y
D
K
D
G
N
K
T
E
Y
T
T
---------
N
A
L
G
D
L
F
R
N
G
T
K
I
D
N
I
----
N
S
S
T
A
P
L
K
A
K
G
T
S
Y
I
N
L
V
Y
S
D
D
D
G
K
T
W
S
E
P
Q
N
I
N
F
Q
V
K
K
D
W
M
K
F
L
G
I
A
P
G
R
G
I
Q
I
K
N
G
E
H
K
G
R
I
V
V
P
V
Y
Y
T
N
E
----
K
G
K
Q
S
S
A
V
I
Y
S
D
D
S
G
K
N
W
T
I
G
E
S
P
N
D
N
R
K
L
E
N
G
K
-
I
I
N
S
K
T
L
S
D
D
A
P
Q
L
T
E
C
Q
V
V
E
M
P
N
G
Q
L
K
L
F
M
R
N
L
S
G
Y
L
N
I
A
T
S
F
D
G
G
A
T
W
D
E
T
V
E
K
D
T
N
V
L
E
P
Y
C
Q
L
S
V
I
N
Y
--
S
Q
KI
D
G
K
D
A
V
I
F
S
N
P
N
A
R
S
R
S
N
G
T
V
R
I
G
L
I
N
QVGTY
E
N
G
E
P
K
Y
E
F
-----
D
W
K
Y
N
K
L
V
K
P
G
Y
Y
A
Y
S
C
L
T
E
L
S
N
G
N
I
G
L
L
Y
E
G
T
P
S
E
E
M
S
Y
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
33
PsiBlast_CBE
54.06
41%
79
- C5 -
-
5TSP
1
?
B:
[2-439]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
E
G
A
V
K
T
E
P
V
D
L
F
H
P
G
F
L
N
S
S
N
------
Y
R
I
P
A
L
F
K
T
K
E
G
T
L
I
A
S
I
D
A
R
R
Q
G
G
A
D
A
PN
N
D
I
D
T
A
V
R
R
S
E
D
G
G
K
T
W
D
E
G
Q
I
I
M
D
Y
P
D
K
S
S
V
----------
I
D
T
T
L
I
Q
D
D
E
T
G
R
I
F
L
L
V
T
H
F
P
S
K
Y
G
F
W
NA
G
L
G
S
----
G
F
K
N
I
D
G
K
E
Y
L
C
L
Y
D
S
S
G
K
-
E
F
T
V
R
E
N
-
V
V
Y
D
K
D
G
N
K
T
E
Y
T
T
---------
N
A
L
G
D
L
F
R
N
G
T
K
I
D
N
I
----
N
S
S
T
A
P
L
K
A
K
G
T
S
Y
I
N
L
V
Y
S
D
D
D
G
K
T
W
S
E
P
Q
N
I
N
F
Q
V
K
K
D
W
M
K
F
L
G
I
A
P
G
R
G
I
Q
I
K
N
G
E
H
K
G
R
I
V
V
P
V
Y
Y
T
N
E
----
K
G
K
Q
S
S
A
V
I
Y
S
D
D
S
G
K
N
W
T
I
G
E
S
P
N
D
N
R
K
L
E
N
G
K
-
I
I
N
S
K
T
L
S
D
D
A
P
Q
L
T
E
C
Q
V
V
E
M
P
N
G
Q
L
K
L
F
M
R
N
L
S
G
Y
L
N
I
A
T
S
F
D
G
G
A
T
W
D
E
T
V
E
K
D
T
N
V
L
E
P
Y
C
Q
L
S
V
I
N
Y
--
S
Q
KI
D
G
K
D
A
V
I
F
S
N
P
N
A
R
S
R
S
N
G
T
V
R
I
G
L
I
N
QVGTY
E
N
G
EPKY
E
F
-----
D
W
K
Y
N
K
L
V
K
P
G
Y
Y
A
Y
S
C
L
T
E
L
S
N
G
N
I
G
L
L
Y
E
G
T
P
S
E
E
M
S
Y
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------