@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : spr1542: (2018-01-14 )
MAFIEKGQEIDMEVIKAETQLSAEALRLKESRDRELADIISGEDDRILLVIGPCSSDNEEAVLEYARRLSALQKKVADKIFMVMRVYTAKPRTNGDGYKGLVHQPDTSKAPSLINGLQAVRQLHYRVITETGLTTADEMLYPSNLILVDDLVSYHAVGARSVEDQEHRFVASGIDAPVGMKNPTSGNLGVMFNAIYAAQNKQTFLYHGQEVETSGNPLAHVILRGAVNEYGNYMPNYYYENLLQAIERYETMGLENPFILIDTNHDNSGKQYMEQIRIVRQTLQNRDWNEKIKKTVRGFMIESYLADGRQNQPEIFGCSITDPCLGWENTEALVEEIYVTLTK
Atome Classification :
(25 SA)
.........10........20........30..--......40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200...-----.-----...210.........220.......230.......240.......250.......260.......270.....---..280.......290.......300.......310..----..--...320--.........330.......340.---
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MAFIEKGQEI
D
M
E
V
I
K
A
E
T
QL
S
A
E
A
L
R
L
K
ESR
D
--
R
E
L
A
D
I
ISGED
D
R
I
L
L
V
IGPCSSD
N
E
E
A
V
L
E
Y
A
R
R
L
S
A
L
Q
K
K
V
A
D
K
I
F
M
V
M
R
V
YTAKPRTNGDGYKGLVHQPDTSK
A
P
S
L
I
N
G
L
Q
A
V
R
Q
L
H
Y
R
V
I
TETGLT
T
A
D
EMLYPS
N
L
I
L
V
D
D
L
V
S
Y
H
AVGARSVE
D
Q
E
H
R
F
V
ASGIDAPVGMKNPTSGNL
G
V
M
F
N
A
I
Y
AAQNK
Q
T
F
L
-----
Y
-----HGQE--VETSGN
P
L
A
H
V
I
L
R
G
A
V
N
E
Y
GNYM
P
N
Y
Y
Y
E
N
L
L
Q
A
I
E
R
Y
E
TMGLEN
P
F
I
L
I
DTNHDN
S
G
K
Q
Y
M
E
Q
I
R
---
I
V
R
Q
T
L
QNR
D
W
N
E
K
I
K
K
T
V
R
G
F
M
I
E
S
Y
L
ADGRQNQP
E
----
I
F
--
G
C
SI----TDPCLGWE
N
T
E
A
L
V
E
E
I
Y
VTLTK---
118
HHSearch
90.00
38%
-29
- C4 -
-
5DCB
2
?
C:
[11-345]
-
K
I
K
E
V
K
E
L
L
P
P
I
A
H
L
Y
E
L
P
I
S
K
E
A
S
G
L
V
H
R
T
R
--
Q
E
I
S
D
L
V
H
G
R
D
K
R
L
L
V
I
I
G
P
C
S
I
H
D
P
K
A
A
L
E
Y
A
E
R
L
L
K
L
R
K
Q
Y
E
N
E
L
L
I
V
M
R
V
Y
F
E
K
P
R
T
T
V
-
G
W
K
G
L
I
N
D
P
H
L
D
G
T
F
D
I
N
F
G
L
R
Q
A
R
S
L
L
L
-
S
L
N
N
M
G
M
P
A
S
T
E
F
L
D
M
I
T
P
Q
Y
Y
A
D
L
I
S
W
G
A
I
G
A
R
T
T
E
S
Q
V
H
R
E
L
A
S
G
L
S
C
P
V
G
F
K
N
G
T
D
G
N
L
K
I
A
I
D
A
I
G
A
A
S
H
S
H
H
F
L
SVTKA
G
-----
H
S
A
I
--
V
H
T
G
G
N
P
D
C
H
V
I
L
R
G
-----
G
-
K
E
P
N
Y
D
A
E
H
V
S
E
A
A
E
Q
L
R
A
A
G
-
V
T
D
K
L
M
I
D
C
S
H
A
N
S
R
K
D
Y
T
R
Q
M
E
---
V
A
Q
D
I
A
---
A
Q
L
E
Q
D
G
G
N
I
M
G
V
M
V
E
S
H
L
V
E
G
R
Q
D
K
P
----------
E
V
Y
GKSI
T
D
A
C
I
G
W
G
A
T
E
E
L
L
A
L
L
A
G
A
N
K
K
---
117
HHSearch
87.91
37%
-25
- C4 -
-
5D04
7
?
D:
[11-345]
-
K
I
K
E
V
K
E
L
L
P
P
I
A
H
L
Y
E
L
P
I
S
K
E
A
S
G
L
V
H
R
T
R
--
Q
E
I
S
D
L
V
H
G
R
D
K
R
L
L
V
I
I
G
P
C
S
I
H
D
P
K
A
A
L
E
Y
A
E
R
L
L
K
L
R
K
Q
Y
E
N
E
L
L
I
V
M
R
V
Y
F
E
K
P
R
T
T
-
V
G
W
K
G
L
I
N
D
P
H
L
D
G
T
F
D
I
N
F
G
L
R
Q
A
R
S
L
L
L
-
S
L
N
N
M
G
M
P
A
S
T
E
F
L
D
M
I
T
P
Q
Y
Y
A
D
L
I
S
W
G
A
I
G
A
R
T
T
E
S
Q
V
H
R
E
L
A
S
G
L
S
C
P
V
G
F
K
N
G
T
D
G
N
L
K
I
A
I
D
A
I
G
A
A
S
H
S
H
H
F
L
SVTKA
G
-----
H
S
A
I
--
A
H
T
G
G
N
P
D
C
H
V
I
L
R
G
-----
G
-
K
E
P
N
Y
D
A
E
H
V
S
E
A
A
E
Q
L
R
A
A
G
-
V
T
D
K
L
M
I
D
C
S
H
A
N
S
R
K
D
Y
T
R
Q
M
E
---
V
A
Q
D
I
A
---
A
Q
L
E
Q
D
G
G
N
I
M
G
V
M
V
E
S
H
L
V
E
G
R
Q
D
K
P
----------
E
V
Y
GKSI
T
D
A
C
I
G
W
G
A
T
E
E
L
L
A
L
L
A
G
A
N
K
K
---
35
PsiBlast_CBE
85.56
38%
-30
- C4 -
-
5DCE
1
?
B:
[27-336]
-----------------
E
L
P
I
S
K
E
A
S
G
L
V
H
R
T
R
--
Q
E
I
S
D
L
V
H
G
R
D
K
R
L
L
V
I
I
G
P
C
S
I
H
D
P
K
A
A
L
E
Y
A
E
R
L
L
K
L
R
K
Q
Y
E
N
E
L
L
I
V
M
R
V
Y
F
E
K
P
R
T
T
-
V
G
W
K
G
L
I
N
D
P
H
L
D
G
T
F
D
I
N
F
G
L
R
Q
A
R
S
L
-
L
L
S
L
N
N
M
G
M
P
A
S
T
E
F
L
D
M
I
T
P
Q
Y
Y
A
D
L
I
S
W
G
A
I
G
A
R
T
T
E
S
Q
V
H
R
E
L
A
S
G
L
S
C
P
V
G
F
K
N
G
T
D
G
N
L
K
I
A
I
D
A
I
G
A
A
S
H
S
H
H
F
L
-----
S
V
T
KAG
H
S
A
I
--
V
H
T
G
G
N
P
D
C
H
V
I
L
R
G
G
K
E
------
P
N
Y
D
A
E
H
V
S
E
A
A
E
Q
L
R
A
A
G
V
T
D
K
-
L
M
I
D
C
S
H
A
N
S
R
K
D
Y
T
R
Q
M
E
---
V
A
Q
D
I
A
A
Q
L
---
E
Q
D
G
G
N
I
M
G
V
M
V
E
S
H
L
V
E
G
R
Q
D
K
P
E
----
V
Y
--
G
K
S
I
----
T
D
A
C
I
G
W
G
A
T
E
E
L
L
------------
134
Fugue
85.55
36%
-23
- C4 -
-
1QR7
1
AROG_ECOLI
A:
[8-350]
L
R
I
K
E
I
K
E
L
L
P
P
V
A
L
L
E
K
F
P
A
T
E
N
A
A
N
T
V
A
H
A
R
--
K
A
I
H
K
I
L
K
G
N
D
D
R
L
L
V
V
I
G
P
C
S
I
H
D
P
V
A
A
K
E
Y
A
T
R
L
L
A
L
R
E
E
L
K
D
E
L
E
I
V
M
R
V
Y
F
E
K
P
R
T
T
-
V
G
W
K
G
L
I
N
D
P
H
M
D
N
S
F
Q
I
N
D
G
L
R
I
A
R
K
L
L
L
D
I
N
D
-
S
G
L
P
A
A
G
E
F
L
D
M
I
T
P
Q
Y
L
A
D
L
M
S
W
G
A
I
G
A
R
T
T
E
S
Q
V
H
R
E
L
A
S
G
L
S
C
P
V
G
F
K
N
G
T
D
G
T
I
K
V
A
I
D
A
I
N
A
A
G
A
P
H
C
F
L
-----
S
V
T
KWG
H
S
A
I
--
V
N
T
S
G
N
G
D
C
H
I
I
L
R
G
G
K
E
------
P
N
Y
S
A
K
H
V
A
E
V
K
E
G
L
N
K
A
G
L
-
P
A
Q
V
M
I
D
F
S
H
A
N
S
S
K
Q
F
K
K
Q
M
D
---
V
C
A
D
V
C
Q
Q
I
A
G
G
E
K
---
A
I
I
G
V
M
V
E
S
H
L
V
E
G
N
Q
S
L
L
A
-----
Y
--
G
K
S
I
----
T
D
A
C
I
G
W
E
D
T
D
A
L
L
R
Q
L
A
N
A
V
K
A
R
R
G
23
PsiBlast_CBE
85.43
38%
-28
- C4 -
-
5CZS
2
?
B:
[27-336]
-----------------
E
L
P
I
S
K
E
A
S
G
L
V
H
R
T
R
--
Q
E
I
S
D
L
V
H
G
R
D
K
R
L
L
V
I
I
G
P
C
S
I
H
D
P
K
A
A
L
E
Y
A
E
R
L
L
K
L
R
K
Q
Y
E
N
E
L
L
I
V
M
R
V
Y
F
A
K
P
R
---
V
G
W
K
G
L
I
N
D
P
H
L
D
G
T
F
D
I
N
F
G
L
R
Q
A
R
S
L
-
L
L
S
L
N
N
M
G
M
P
A
S
T
E
F
L
D
M
I
T
P
Q
Y
Y
A
D
L
I
S
W
G
A
I
G
A
R
T
T
E
S
Q
V
H
R
E
L
A
S
G
L
S
C
P
V
G
F
K
N
G
T
D
G
N
L
K
I
A
I
D
A
I
G
A
A
S
H
S
H
H
F
L
-----
S
V
T
K
AG
H
S
A
I
--
V
H
T
G
G
N
P
D
C
H
V
I
L
R
G
G
K
E
------
P
N
Y
D
A
E
H
V
S
E
A
A
E
Q
L
R
A
A
G
V
T
D
K
-
L
M
I
D
C
S
H
A
N
S
R
K
D
Y
T
R
Q
M
E
---
V
A
Q
D
I
A
A
Q
L
---
E
Q
D
G
G
N
I
M
G
V
M
V
E
S
H
L
V
E
G
R
Q
D
K
P
E
----
V
Y
--
G
K
S
I
----
T
D
A
C
I
G
W
G
A
T
E
E
L
L
------------
33
PsiBlast_CBE
85.38
38%
-29
- C4 -
-
5DCE
1
?
D:
[27-336]
-----------------
E
L
P
I
S
K
E
A
S
G
L
V
H
R
T
R
--
Q
E
I
S
D
L
V
H
G
R
D
K
R
L
L
V
I
I
G
P
C
S
I
H
D
P
K
A
A
L
E
Y
A
E
R
L
L
K
L
R
K
Q
Y
E
N
E
L
L
I
V
M
R
V
Y
F
E
K
P
R
T
T
-
V
G
W
K
G
L
I
N
D
P
H
L
D
G
T
F
D
I
N
F
G
L
R
Q
A
R
S
L
-
L
L
S
L
N
N
M
G
M
P
A
S
T
E
F
L
D
M
I
T
P
Q
Y
Y
A
D
L
I
S
W
G
A
I
G
A
R
T
T
E
S
Q
V
H
R
E
L
A
S
G
L
S
C
P
V
G
F
K
N
G
T
D
G
N
L
K
I
A
I
D
A
I
G
A
A
S
H
S
H
H
F
L
-----
S
VTKAG
H
S
A
I
--
V
H
T
G
G
N
P
D
C
H
V
I
L
R
G
G
K
E
------
P
N
Y
D
A
E
H
V
S
E
A
A
E
Q
L
R
A
A
G
V
T
D
K
-
L
M
I
D
C
S
H
A
N
S
R
K
D
Y
T
R
Q
M
E
---
V
A
Q
D
I
A
A
Q
L
---
E
Q
D
G
G
N
I
M
G
V
M
V
E
S
H
L
V
E
G
R
Q
D
K
P
E
----
V
Y
--
G
K
S
I
----
T
D
A
C
I
G
W
G
A
T
E
E
L
L
------------
3
PsiBlast_PDB
85.30
38%
-29
- C4 -
-
5CZT
1
?
A:
[27-336]
-----------------
E
L
P
I
S
K
E
A
S
G
L
V
H
R
T
R
--
Q
E
I
S
D
L
V
H
G
R
D
K
R
L
L
V
I
I
G
P
C
S
I
H
D
P
K
A
A
L
E
Y
A
E
R
L
L
K
L
R
K
Q
Y
E
N
E
L
L
I
V
M
R
V
Y
F
E
K
P
R
T
T
-
V
G
W
K
G
L
I
N
D
P
H
L
D
G
T
F
D
I
N
F
G
L
R
Q
A
R
S
L
-
L
L
S
L
N
N
M
G
M
P
A
S
T
E
F
L
D
M
I
T
P
Q
Y
Y
A
D
L
I
S
W
G
A
I
G
A
R
T
T
E
S
Q
V
H
R
A
L
A
S
G
L
S
C
P
V
G
F
K
N
G
T
D
G
N
L
K
I
A
I
D
A
I
G
A
A
S
H
S
H
H
F
L
-----
S
V
T
KAG
H
S
A
I
--
V
H
T
G
G
N
P
D
C
H
V
I
L
R
G
G
K
E
------
P
N
Y
D
A
E
H
V
S
E
A
A
E
Q
L
R
A
A
G
V
T
D
K
-
L
M
I
D
C
S
H
A
N
S
R
K
D
Y
T
R
Q
M
E
---
V
A
Q
D
I
A
A
Q
L
---
E
Q
D
G
G
N
I
M
G
V
M
V
E
S
H
L
V
E
G
R
Q
D
K
P
E
----
V
Y
--
G
K
S
I
----
T
D
A
C
I
G
W
G
A
T
E
E
L
L
------------
29
PsiBlast_CBE
85.29
38%
-29
- C4 -
-
5CZT
1
?
B:
[27-336]
-----------------
E
L
P
I
S
K
E
A
S
G
L
V
H
R
T
R
--
Q
E
I
S
D
L
V
H
G
R
D
K
R
L
L
V
I
I
G
P
C
S
I
H
D
P
K
A
A
L
E
Y
A
E
R
L
L
K
L
R
K
Q
Y
E
N
E
L
L
I
V
M
R
V
Y
F
E
K
P
R
---
V
G
W
K
G
L
I
N
D
P
H
L
D
G
T
F
D
I
N
F
G
L
R
Q
A
R
S
L
-
L
L
S
L
N
N
M
G
M
P
A
S
T
E
F
L
D
M
I
T
P
Q
Y
Y
A
D
L
I
S
W
G
A
I
G
A
R
T
T
E
S
Q
V
H
R
A
L
A
S
G
L
S
C
P
V
G
F
K
N
G
T
D
G
N
L
K
I
A
I
D
A
I
G
A
A
S
H
S
H
H
F
L
-----
S
V
T
KAG
H
S
A
I
--
V
H
T
G
G
N
P
D
C
H
V
I
L
R
G
G
K
E
------
P
N
Y
D
A
E
H
V
S
E
A
A
E
Q
L
R
A
A
G
V
T
D
K
-
L
M
I
D
C
S
H
A
N
S
R
K
D
Y
T
R
Q
M
E
---
V
A
Q
D
I
A
A
Q
L
---
E
Q
D
G
G
N
I
M
G
V
M
V
E
S
H
L
V
E
G
R
Q
D
K
P
E
----
V
Y
--
G
K
S
I
----
T
D
A
C
I
G
W
G
A
T
E
E
L
L
------------
34
PsiBlast_CBE
85.12
38%
-27
- C4 -
-
5DCE
1
?
C:
[27-336]
-----------------
E
L
P
I
S
K
E
A
S
G
L
V
H
R
T
R
--
Q
E
I
S
D
L
V
H
G
R
D
K
R
L
L
V
I
I
G
P
C
S
I
H
D
P
K
A
A
L
E
Y
A
E
R
L
L
K
L
R
K
Q
Y
E
N
E
L
L
I
V
M
R
V
Y
F
E
K
P
R
T
T
-
V
G
W
K
G
L
I
N
D
P
H
L
D
G
T
F
D
I
N
F
G
L
R
Q
A
R
S
L
-
L
L
S
L
N
N
M
G
M
P
A
S
T
E
F
L
D
M
I
T
P
Q
Y
Y
A
D
L
I
S
W
G
A
I
G
A
R
T
T
E
S
Q
V
H
R
E
L
A
S
G
L
S
C
P
V
G
F
K
N
G
T
D
G
N
L
K
I
A
I
D
A
I
G
A
A
S
H
S
H
H
F
L
-----
S
V
T
KAG
H
S
A
I
--
V
H
T
G
G
N
P
D
C
H
V
I
L
R
G
G
K
E
------
P
N
Y
D
A
E
H
V
S
E
A
A
E
Q
L
R
A
A
G
V
T
D
K
-
L
M
I
D
C
S
H
A
N
S
R
K
D
Y
T
R
Q
M
E
---
V
A
Q
D
I
A
A
Q
L
---
E
Q
D
G
G
N
I
M
G
V
M
V
E
S
H
L
V
E
G
R
Q
D
K
P
E
----
V
Y
--
G
K
S
I
----
T
D
A
C
I
G
W
G
A
T
E
E
L
L
------------
52
PsiBlast_CBE
85.04
38%
-25
- C4 -
-
4UC5
1
?
C:
[27-336]
-----------------
E
L
P
I
S
K
E
A
S
G
L
V
H
R
T
R
--
Q
E
I
S
D
L
V
H
G
R
D
K
R
L
L
V
I
I
G
P
C
S
I
H
D
P
K
A
A
L
E
Y
A
E
R
L
L
K
L
R
K
Q
Y
E
N
E
L
L
I
V
M
R
V
Y
F
E
K
P
R
T
T
-
V
G
W
K
G
L
I
N
D
P
H
L
D
G
T
F
D
I
N
F
G
L
R
Q
A
R
S
L
-
L
L
S
L
N
N
M
G
M
P
A
S
T
E
F
L
D
M
I
T
P
Q
Y
Y
A
D
L
I
S
W
G
A
I
G
A
R
T
T
E
S
Q
V
H
R
E
L
A
S
G
L
S
C
P
V
G
F
K
N
G
T
D
G
N
L
K
I
A
I
D
A
I
G
A
A
S
H
S
H
H
F
L
-----
S
VTKAG
H
S
A
I
--
V
H
T
G
G
N
P
D
C
H
V
I
L
R
G
G
K
E
------
P
N
Y
D
A
E
H
V
S
E
A
A
E
Q
L
R
A
A
G
V
T
D
K
-
L
M
I
D
C
S
H
A
N
S
R
K
D
Y
T
R
Q
M
E
---
V
A
Q
D
I
A
A
Q
L
---
E
Q
D
G
G
N
I
M
G
V
M
V
E
S
H
L
V
E
G
R
Q
D
K
P
E
----
V
Y
--
G
K
S
I
----
T
D
A
C
I
G
W
G
A
T
E
E
L
L
------------
71
PsiBlast_CBE
85.02
38%
-27
- C4 -
-
5D05
3
?
C:
[27-336]
-----------------
E
L
P
I
S
K
E
A
S
G
L
V
H
R
T
R
--
Q
E
I
S
D
L
V
H
G
R
D
K
R
L
L
V
I
I
G
P
C
S
I
H
D
P
K
A
A
L
E
Y
A
E
R
L
L
K
L
R
K
Q
Y
E
N
E
L
L
I
V
M
R
V
Y
F
E
K
P
R
T
T
-
V
G
W
A
G
L
I
N
D
P
H
L
D
G
T
F
D
I
N
F
G
L
R
Q
A
R
S
L
-
L
L
S
L
N
N
M
G
M
P
A
S
T
E
F
L
D
M
I
T
P
Q
Y
Y
A
D
L
I
S
W
G
A
I
G
A
R
T
T
E
S
Q
V
H
R
E
L
A
S
G
L
S
C
P
V
G
F
K
N
G
T
D
G
N
L
K
I
A
I
D
A
I
G
A
A
S
H
S
H
H
F
L
-----
S
VTKAG
H
S
A
I
--
V
H
T
G
G
N
P
D
C
H
V
I
L
R
G
G
K
E
------
P
N
Y
D
A
E
H
V
S
E
A
A
E
Q
L
R
A
A
G
V
T
D
K
-
L
M
I
D
C
S
H
A
N
S
R
K
D
Y
T
R
Q
M
E
---
V
A
Q
D
I
A
A
Q
L
---
E
Q
D
G
G
N
I
M
G
V
M
V
E
S
H
L
V
E
G
R
Q
D
K
P
E
----
V
Y
--
G
K
S
I
----
T
D
A
C
I
G
W
G
A
T
E
E
L
L
------------
18
PsiBlast_PDB
85.00
38%
-28
- C4 -
-
5D05
4
?
A:
[27-336]
-----------------
E
L
P
I
S
K
E
A
S
G
L
V
H
R
T
R
--
Q
E
I
S
D
L
V
H
G
R
D
K
R
L
L
V
I
I
G
P
C
S
I
H
D
P
K
A
A
L
E
Y
A
E
R
L
L
K
L
R
K
Q
Y
E
N
E
L
L
I
V
M
R
V
Y
F
E
K
P
R
T
T
-
V
G
W
A
G
L
I
N
D
P
H
L
D
G
T
F
D
I
N
F
G
L
R
Q
A
R
S
L
-
L
L
S
L
N
N
M
G
M
P
A
S
T
E
F
L
D
M
I
T
P
Q
Y
Y
A
D
L
I
S
W
G
A
I
G
A
R
T
T
E
S
Q
V
H
R
E
L
A
S
G
L
S
C
P
V
G
F
K
N
G
T
D
G
N
L
K
I
A
I
D
A
I
G
A
A
S
H
S
H
H
F
L
-----
S
V
T
KAG
H
S
A
I
--
V
H
T
G
G
N
P
D
C
H
V
I
L
R
G
G
K
E
------
P
N
Y
D
A
E
H
V
S
E
A
A
E
Q
L
R
A
A
G
V
T
D
K
-
L
M
I
D
C
S
H
A
N
S
R
K
D
Y
T
R
Q
M
E
---
V
A
Q
D
I
A
A
Q
L
---
E
Q
D
G
G
N
I
M
G
V
M
V
E
S
H
L
V
E
G
R
Q
D
K
P
E
----
V
Y
--
G
K
S
I
----
T
D
A
C
I
G
W
G
A
T
E
E
L
L
------------
21
PsiBlast_CBE
84.97
38%
-28
- C4 -
-
5CZS
2
?
D:
[27-336]
-----------------
E
L
P
I
S
K
E
A
S
G
L
V
H
R
T
R
--
Q
E
I
S
D
L
V
H
G
R
D
K
R
L
L
V
I
I
G
P
C
S
I
H
D
P
K
A
A
L
E
Y
A
E
R
L
L
K
L
R
K
Q
Y
E
N
E
L
L
I
V
M
R
V
Y
F
A
K
P
R
---
V
G
W
K
G
L
I
N
D
P
H
L
D
G
T
F
D
I
N
F
G
L
R
Q
A
R
S
L
-
L
L
S
L
N
N
M
G
M
P
A
S
T
E
F
L
D
M
I
T
P
Q
Y
Y
A
D
L
I
S
W
G
A
I
G
A
R
T
T
E
S
Q
V
H
R
E
L
A
S
G
L
S
C
P
V
G
F
K
N
G
T
D
G
N
L
K
I
A
I
D
A
I
G
A
A
S
H
S
H
H
F
L
-----
S
VTKAG
H
S
A
I
--
V
H
T
G
G
N
P
D
C
H
V
I
L
R
G
G
K
E
------
P
N
Y
D
A
E
H
V
S
E
A
A
E
Q
L
R
A
A
G
V
T
D
K
-
L
M
I
D
C
S
H
A
N
S
R
K
D
Y
T
R
Q
M
E
---
V
A
Q
D
I
A
A
Q
L
---
E
Q
D
G
G
N
I
M
G
V
M
V
E
S
H
L
V
E
G
R
Q
D
K
P
E
----
V
Y
--
G
K
S
I
----
T
D
A
C
I
G
W
G
A
T
E
E
L
L
------------
38
PsiBlast_CBE
84.94
38%
-28
- C4 -
-
5DCD
2
?
B:
[27-336]
-----------------
E
L
P
I
S
K
E
A
S
G
L
V
H
R
T
R
--
Q
E
I
S
D
L
V
H
G
R
D
K
R
L
L
V
I
I
G
P
C
S
I
H
D
P
K
A
A
L
E
Y
A
E
R
L
L
K
L
R
K
Q
Y
E
N
E
L
L
I
V
M
R
V
Y
F
E
K
P
R
T
T
-
V
G
W
K
G
L
I
N
D
P
H
L
D
G
T
F
D
I
N
F
G
L
R
Q
A
R
S
L
-
L
L
S
L
N
N
M
G
M
P
A
S
T
E
F
L
D
M
I
T
P
Q
Y
Y
A
D
L
I
S
W
G
A
I
G
A
R
T
T
E
S
Q
V
H
R
E
L
A
S
G
L
S
C
P
V
G
F
K
N
G
T
D
G
N
L
K
I
A
I
D
A
I
G
A
A
S
H
S
H
H
F
L
-----
S
VTKAG
H
S
A
I
--
V
H
T
G
G
N
P
D
C
H
V
I
L
R
G
G
K
E
------
P
N
Y
D
A
E
H
V
S
E
A
A
E
Q
L
R
A
A
G
V
T
D
K
-
L
M
I
D
C
S
H
A
N
S
R
K
D
Y
T
R
Q
M
E
---
V
A
Q
D
I
A
A
Q
L
---
E
Q
D
G
G
N
I
M
G
V
M
V
E
S
H
L
V
E
G
R
Q
D
K
P
E
----
V
Y
--
G
K
S
I
----
T
D
A
C
I
G
W
G
A
T
E
E
L
L
------------
9
PsiBlast_PDB
84.92
38%
-28
- C4 -
-
4UC5
2
?
A:
[27-336]
-----------------
E
L
P
I
S
K
E
A
S
G
L
V
H
R
T
R
--
Q
E
I
S
D
L
V
H
G
R
D
K
R
L
L
V
I
I
G
P
C
S
I
H
D
P
K
A
A
L
E
Y
A
E
R
L
L
K
L
R
K
Q
Y
E
N
E
L
L
I
V
M
R
V
Y
F
E
K
P
R
T
T
-
V
G
W
K
G
L
I
N
D
P
H
L
D
G
T
F
D
I
N
F
G
L
R
Q
A
R
S
L
-
L
L
S
L
N
N
M
G
M
P
A
S
T
E
F
L
D
M
I
T
P
Q
Y
Y
A
D
L
I
S
W
G
A
I
G
A
R
T
T
E
S
Q
V
H
R
E
L
A
S
G
L
S
C
P
V
G
F
K
N
G
T
D
G
N
L
K
I
A
I
D
A
I
G
A
A
S
H
S
H
H
F
L
-----
S
V
T
KAG
H
S
A
I
--
V
H
T
G
G
N
P
D
C
H
V
I
L
R
G
G
K
E
------
P
N
Y
D
A
E
H
V
S
E
A
A
E
Q
L
R
A
A
G
V
T
D
K
-
L
M
I
D
C
S
H
A
N
S
R
K
D
Y
T
R
Q
M
E
---
V
A
Q
D
I
A
A
Q
L
---
E
Q
D
G
G
N
I
M
G
V
M
V
E
S
H
L
V
E
G
R
Q
D
K
P
E
----
V
Y
--
G
K
S
I
----
T
D
A
C
I
G
W
G
A
T
E
E
L
L
------------
39
PsiBlast_CBE
84.91
38%
-28
- C4 -
-
5DCB
3
?
D:
[27-336]
-----------------
E
L
P
I
S
K
E
A
S
G
L
V
H
R
T
R
--
Q
E
I
S
D
L
V
H
G
R
D
K
R
L
L
V
I
I
G
P
C
S
I
H
D
P
K
A
A
L
E
Y
A
E
R
L
L
K
L
R
K
Q
Y
E
N
E
L
L
I
V
M
R
V
Y
F
E
K
P
R
T
T
-
V
G
W
K
G
L
I
N
D
P
H
L
D
G
T
F
D
I
N
F
G
L
R
Q
A
R
S
L
-
L
L
S
L
N
N
M
G
M
P
A
S
T
E
F
L
D
M
I
T
P
Q
Y
Y
A
D
L
I
S
W
G
A
I
G
A
R
T
T
E
S
Q
V
H
R
E
L
A
S
G
L
S
C
P
V
G
F
K
N
G
T
D
G
N
L
K
I
A
I
D
A
I
G
A
A
S
H
S
H
H
F
L
-----
S
VTKAG
H
S
A
I
--
V
H
T
G
G
N
P
D
C
H
V
I
L
R
G
G
K
E
------
P
N
Y
D
A
E
H
V
S
E
A
A
E
Q
L
R
A
A
G
V
T
D
K
-
L
M
I
D
C
S
H
A
N
S
R
K
D
Y
T
R
Q
M
E
---
V
A
Q
D
I
A
A
Q
L
---
E
Q
D
G
G
N
I
M
G
V
M
V
E
S
H
L
V
E
G
R
Q
D
K
P
E
----
V
Y
--
G
K
S
I
----
T
D
A
C
I
G
W
G
A
T
E
E
L
L
------------
36
PsiBlast_CBE
84.90
38%
-27
- C4 -
-
5DCD
2
?
D:
[27-336]
-----------------
E
L
P
I
S
K
E
A
S
G
L
V
H
R
T
R
--
Q
E
I
S
D
L
V
H
G
R
D
K
R
L
L
V
I
I
G
P
C
S
I
H
D
P
K
A
A
L
E
Y
A
E
R
L
L
K
L
R
K
Q
Y
E
N
E
L
L
I
V
M
R
V
Y
F
E
K
P
R
T
T
-
V
G
W
K
G
L
I
N
D
P
H
L
D
G
T
F
D
I
N
F
G
L
R
Q
A
R
S
L
-
L
L
S
L
N
N
M
G
M
P
A
S
T
E
F
L
D
M
I
T
P
Q
Y
Y
A
D
L
I
S
W
G
A
I
G
A
R
T
T
E
S
Q
V
H
R
E
L
A
S
G
L
S
C
P
V
G
F
K
N
G
T
D
G
N
L
K
I
A
I
D
A
I
G
A
A
S
H
S
H
H
F
L
-----
S
VTKAG
H
S
A
I
--
V
H
T
G
G
N
P
D
C
H
V
I
L
R
G
G
K
E
------
P
N
Y
D
A
E
H
V
S
E
A
A
E
Q
L
R
A
A
G
V
T
D
K
-
L
M
I
D
C
S
H
A
N
S
R
K
D
Y
T
R
Q
M
E
---
V
A
Q
D
I
A
A
Q
L
---
E
Q
D
G
G
N
I
M
G
V
M
V
E
S
H
L
V
E
G
R
Q
D
K
P
E
----
V
Y
--
G
K
S
I
----
T
D
A
C
I
G
W
G
A
T
E
E
L
L
------------
24
PsiBlast_CBE
84.86
38%
-28
- C4 -
-
5CZ0
1
?
D:
[27-336]
-----------------
E
L
P
I
S
K
E
A
S
G
L
V
H
R
T
R
--
Q
E
I
S
D
L
V
H
G
R
D
K
R
L
L
V
I
I
G
P
C
S
I
H
D
P
K
A
A
L
E
Y
A
E
R
L
L
K
L
R
K
Q
Y
E
N
E
L
L
I
V
M
R
V
Y
F
A
K
P
R
T
T
-
V
G
W
K
G
L
I
N
D
P
H
L
D
G
T
F
D
I
N
F
G
L
R
Q
A
R
S
L
-
L
L
S
L
N
N
M
G
M
P
A
S
T
E
F
L
D
M
I
T
P
Q
Y
Y
A
D
L
I
S
W
G
A
I
G
A
R
T
T
E
S
Q
V
H
R
E
L
A
S
G
L
S
C
P
V
G
F
K
N
G
T
D
G
N
L
K
I
A
I
D
A
I
G
A
A
S
H
S
H
H
F
L
-----
S
VTKAG
H
S
A
I
--
V
H
T
G
G
N
P
D
C
H
V
I
L
R
G
G
K
E
------
P
N
Y
D
A
E
H
V
S
E
A
A
E
Q
L
R
A
A
G
V
T
D
K
-
L
M
I
D
C
S
H
A
N
S
R
K
D
Y
T
R
Q
M
E
---
V
A
Q
D
I
A
A
Q
L
---
E
Q
D
G
G
N
I
M
G
V
M
V
E
S
H
L
V
E
G
R
Q
D
K
P
E
----
V
Y
--
G
K
S
I
----
T
D
A
C
I
G
W
G
A
T
E
E
L
L
------------
72
PsiBlast_CBE
84.84
38%
-28
- C4 -
-
5D05
4
?
B:
[27-336]
-----------------
E
L
P
I
S
K
E
A
S
G
L
V
H
R
T
R
--
Q
E
I
S
D
L
V
H
G
R
D
K
R
L
L
V
I
I
G
P
C
S
I
H
D
P
K
A
A
L
E
Y
A
E
R
L
L
K
L
R
K
Q
Y
E
N
E
L
L
I
V
M
R
V
Y
F
E
K
P
R
T
T
-
V
G
W
A
G
L
I
N
D
P
H
L
D
G
T
F
D
I
N
F
G
L
R
Q
A
R
S
L
-
L
L
S
L
N
N
M
G
M
P
A
S
T
E
F
L
D
M
I
T
P
Q
Y
Y
A
D
L
I
S
W
G
A
I
G
A
R
T
T
E
S
Q
V
H
R
E
L
A
S
G
L
S
C
P
V
G
F
K
N
G
T
D
G
N
L
K
I
A
I
D
A
I
G
A
A
S
H
S
H
H
F
L
-----
S
V
T
KAG
H
S
A
I
--
V
H
T
G
G
N
P
D
C
H
V
I
L
R
G
G
K
E
------
P
N
Y
D
A
E
H
V
S
E
A
A
E
Q
L
R
A
A
G
V
T
D
K
-
L
M
I
D
C
S
H
A
N
S
R
K
D
Y
T
R
Q
M
E
---
V
A
Q
D
I
A
A
Q
L
---
E
Q
D
G
G
N
I
M
G
V
M
V
E
S
H
L
V
E
G
R
Q
D
K
P
E
----
V
Y
--
G
K
S
I
----
T
D
A
C
I
G
W
G
A
T
E
E
L
L
------------
22
PsiBlast_CBE
84.82
38%
-30
- C4 -
-
5CZS
4
?
C:
[27-336]
-----------------
E
L
P
I
S
K
E
A
S
G
L
V
H
R
T
R
--
Q
E
I
S
D
L
V
H
G
R
D
K
R
L
L
V
I
I
G
P
C
S
I
H
D
P
K
A
A
L
E
Y
A
E
R
L
L
K
L
R
K
Q
Y
E
N
E
L
L
I
V
M
R
V
Y
F
A
K
P
R
-
T
-
V
G
W
K
G
L
I
N
D
P
H
L
D
G
T
F
D
I
N
F
G
L
R
Q
A
R
S
L
-
L
L
S
L
N
N
M
G
M
P
A
S
T
E
F
L
D
M
I
T
P
Q
Y
Y
A
D
L
I
S
W
G
A
I
G
A
R
T
T
E
S
Q
V
H
R
E
L
A
S
G
L
S
C
P
V
G
F
K
N
G
T
D
G
N
L
K
I
A
I
D
A
I
G
A
A
S
H
S
H
H
F
L
-----
S
V
TKA
G
H
S
A
I
--
V
H
T
G
G
N
P
D
C
H
V
I
L
R
G
G
K
E
------
P
N
Y
D
A
E
H
V
S
E
A
A
E
Q
L
R
A
A
G
V
T
D
K
-
L
M
I
D
C
S
H
A
N
S
R
K
D
Y
T
R
Q
M
E
---
V
A
Q
D
I
A
A
Q
L
---
E
Q
D
G
G
N
I
M
G
V
M
V
E
S
H
L
V
E
G
R
Q
D
K
P
E
----
V
Y
--
G
K
S
I
----
T
D
A
C
I
G
W
G
A
T
E
E
L
L
------------
114
HHSearch
83.52
34%
-11
- C4 -
-
1OF8
4
AROG_YEAST
B:
[25-363]
--
I
L
G
Y
D
P
L
A
S
P
A
L
L
Q
V
Q
I
P
A
T
P
T
S
L
E
T
A
K
R
G
R
--
R
E
A
I
D
I
I
T
G
K
D
D
R
V
L
V
I
V
G
P
C
S
I
H
D
L
E
A
A
Q
E
Y
A
L
R
L
K
K
L
S
D
E
L
K
G
D
L
S
I
I
M
R
A
Y
L
E
K
P
R
T
T
-
V
G
W
K
G
L
I
N
D
P
D
V
N
N
T
F
N
I
N
K
G
L
Q
S
A
R
Q
L
F
V
-
N
L
T
N
I
G
L
P
I
G
S
E
M
L
D
T
I
S
P
Q
Y
L
A
D
L
V
S
F
G
A
I
G
A
R
T
T
E
S
Q
L
H
R
E
L
A
S
G
L
S
F
P
V
G
F
K
N
G
T
D
G
T
L
N
V
A
V
D
A
C
Q
A
A
A
H
S
H
H
F
M
GVTKH
G
-----
V
A
A
I
--
T
T
T
K
G
N
E
H
C
F
V
I
L
R
G
-----
G
K
K
G
T
N
Y
D
A
K
S
V
A
E
A
K
A
Q
L
P
A
---
G
S
N
G
L
M
I
D
Y
S
H
G
N
S
N
K
D
F
R
N
Q
P
K
---
V
N
D
V
V
C
---
E
Q
I
A
N
G
E
N
A
I
T
G
V
M
I
E
S
N
I
N
E
G
N
Q
G
I
P
-------KA
G
L
K
Y
GVSI
T
D
A
C
I
G
W
E
T
T
E
D
V
L
R
K
L
A
A
A
V
R
Q
---
113
PsiBlast_CBE
74.07
35%
43
- C4 -
-
1OF8
4
AROG_YEAST
B:
[38-361]
-----------------
Q
V
Q
I
P
A
T
P
T
S
L
E
T
A
K
R
GR
R
E
A
I
D
I
I
T
G
K
D
D
R
V
L
V
I
V
G
P
C
S
I
H
D
L
E
A
A
Q
E
Y
A
L
R
L
K
K
L
S
D
E
L
K
G
D
L
S
I
I
M
R
A
Y
L
E
K
P
R
T
T
-
V
G
W
K
G
L
I
N
D
P
D
V
N
N
T
F
N
I
N
K
G
L
Q
S
A
R
Q
L
-
F
V
N
L
T
N
I
G
L
P
I
G
S
E
M
L
D
T
I
S
P
Q
Y
L
A
D
L
V
S
F
G
A
I
G
A
R
T
T
E
S
Q
L
H
R
E
L
A
S
G
L
S
F
P
V
G
F
K
N
G
T
D
G
T
L
N
V
A
V
D
A
C
Q
A
A
A
H
S
H
H
F
M
GVT--
K
-----
H
G
V
A
AI
T
T
T
K
G
N
E
H
C
F
V
I
L
R
G
-----
G
K
K
G
T
N
Y
D
A
K
S
V
A
E
A
K
A
Q
L
P
A
---
G
S
N
G
L
M
I
D
Y
S
H
G
N
S
N
K
D
F
R
N
Q
P
K
VND
V
V
C
E
Q
I
A
N
G
E
------
N
A
I
T
G
V
M
I
E
S
N
I
N
E
G
N
Q
G
I
P
-KAGL
K
Y
--
G
V
S
I
----
T
D
A
C
I
G
W
E
T
T
E
D
V
L
R
K
L
A
A
A
V
-----
109
PsiBlast_CBE
73.62
35%
43
- C4 -
-
1OFO
1
AROG_YEAST
A:
[38-361]
-----------------
Q
V
Q
I
P
A
T
P
T
S
L
E
T
A
K
R
G
R
R
E
A
I
D
I
I
T
G
K
D
D
R
V
L
V
I
V
G
P
C
S
I
H
D
L
E
A
A
Q
E
Y
A
L
R
L
K
K
L
S
D
E
L
K
G
D
L
S
I
I
M
R
A
Y
L
E
K
P
R
T
T
-
V
G
W
K
G
L
I
N
D
P
D
V
N
N
T
F
N
I
N
K
G
L
Q
S
A
R
Q
L
-
F
V
N
L
T
N
I
G
L
P
I
G
S
E
M
L
D
T
I
S
P
Q
Y
L
A
D
L
V
S
F
G
A
I
G
A
R
T
T
E
S
Q
L
H
R
E
L
A
S
G
L
S
F
P
V
G
F
K
N
G
T
D
G
T
L
N
V
A
V
D
A
C
Q
A
A
A
H
S
H
H
F
M
G
V
T
--
K
-----
H
G
V
A
A
I
T
T
T
K
G
N
E
H
C
F
V
I
L
R
G
-----
G
K
K
G
T
N
Y
D
A
K
S
V
A
E
A
K
A
Q
L
P
A
---
G
S
N
G
L
M
I
D
Y
S
H
G
N
S
N
K
D
F
R
N
Q
P
K
V
N
D
V
V
C
E
Q
I
A
N
G
E
------
N
A
I
T
G
V
M
I
E
S
N
I
N
E
G
N
Q
G
I
P
-AGL-
K
Y
--
G
V
S
I
----
T
D
A
C
I
G
W
E
T
T
E
D
V
L
R
K
L
A
A
A
V
-----
111
PsiBlast_CBE
73.26
35%
40
- C4 -
-
1OFA
4
AROG_YEAST
B:
[38-361]
-----------------
Q
V
Q
I
P
A
T
P
T
S
L
E
T
A
K
R
GR
R
E
A
I
D
I
I
T
G
K
D
D
R
V
L
V
I
V
G
P
C
S
I
H
D
L
E
A
A
Q
E
Y
A
L
R
L
K
K
L
S
D
E
L
K
G
D
L
S
I
I
M
R
A
Y
L
E
K
P
R
T
T
-
V
G
W
K
G
L
I
N
D
P
D
V
N
N
T
F
N
I
N
K
G
L
Q
S
A
R
Q
L
-
F
V
N
L
T
N
I
G
L
P
I
G
S
E
M
L
D
T
I
S
P
Q
Y
L
A
D
L
V
S
F
G
A
I
G
A
R
T
T
E
S
Q
L
H
R
E
L
A
S
G
L
S
F
P
V
G
F
K
N
G
T
D
G
T
L
N
V
A
V
D
A
C
Q
A
A
A
H
S
H
H
F
M
GVT--
K
-----
H
G
V
A
AI
T
T
T
K
G
N
E
H
C
F
V
I
L
R
G
-----
G
K
K
G
T
N
Y
D
A
K
S
V
A
E
A
K
A
Q
L
P
A
---
G
S
N
G
L
M
I
D
Y
S
H
G
N
S
N
K
D
F
R
N
Q
P
K
VND
V
V
C
E
Q
I
A
N
G
E
------
N
A
I
T
G
V
M
I
E
S
N
I
N
E
G
N
Q
G
-------
K
Y
--
G
V
S
I
----
T
D
A
C
I
G
W
E
T
T
E
D
V
L
R
K
L
A
A
A
V
-----
112
PsiBlast_CBE
73.22
35%
45
- C4 -
-
1OFA
3
AROG_YEAST
A:
[38-361]
-----------------
Q
V
Q
I
P
A
T
P
T
S
L
E
T
A
K
R
G
R
R
E
A
I
D
I
I
T
G
K
D
D
R
V
L
V
I
V
G
P
C
S
I
H
D
L
E
A
A
Q
E
Y
A
L
R
L
K
K
L
S
D
E
L
K
G
D
L
S
I
I
M
R
A
Y
L
E
K
P
R
T
T
-
V
G
W
K
G
L
I
N
D
P
D
V
N
N
T
F
N
I
N
K
G
L
Q
S
A
R
Q
L
-
F
V
N
L
T
N
I
G
L
P
I
G
S
E
M
L
D
T
I
S
P
Q
Y
L
A
D
L
V
S
F
G
A
I
G
A
R
T
T
E
S
Q
L
H
R
E
L
A
S
G
L
S
F
P
V
G
F
K
N
G
T
D
G
T
L
N
V
A
V
D
A
C
Q
A
A
A
H
S
H
H
F
M
G
V
T
--
K
-----
H
G
V
A
A
I
T
T
T
K
G
N
E
H
C
F
V
I
L
R
G
-----
G
K
K
G
T
N
Y
D
A
K
S
V
A
E
A
K
A
Q
L
P
A
---
G
S
N
G
L
M
I
D
Y
S
H
G
N
S
N
K
D
F
R
N
Q
P
K
V
N
D
V
V
C
E
Q
I
A
N
G
E
------
N
A
I
T
G
V
M
I
E
S
N
I
N
E
G
N
Q
G
I
P
-AGL-
K
Y
--
G
V
S
I
----
T
D
A
C
I
G
W
E
T
T
E
D
V
L
R
K
L
A
A
A
V
-----