@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : spr1543: (2018-01-14 )
MVFTAKSSKINIEEVRALSKLEGQALERKSQRDQELEAIIRGEDQRILLVIGPCSSDNEEAVLEYANRLAVLQEEVADRIFMVMRVYTAKPRTNGDGYKGLIHQPNATEAPSLINGIKAVRHLHYRVITETGMTTADEMLYPENLPLVDDLISYMAVGARSVEDQQHRFVASGAGFSTGFKNPTSGNLNVMFNGIYAAQNKQSFLFLGKEVETTGNPLSHAILRGALNEYGKNIPNYYYDNLIDTIAQYEKMGLENPFIIIDTNHDNSGKQYIEQIRIVRQTLINRAWNEKIKQFVRGFMIESYLEDGRQNEPEVFGKSITDPCLGWDNTEALVREIYKTLGE
Atome Classification :
(24 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200...-----.-----..-----.210---.........220.......230.......240.......250.......260.......270.......280.......290---.......300.......310.----.----.....320.......330.......340.---
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
M
V
FTAKSSKI
N
I
E
E
V
R
A
L
S
K
LE
G
Q
A
L
E
R
K
S
Q
R
D
Q
E
L
E
A
I
IRGED
Q
R
I
L
L
V
IGPCSSD
N
E
E
A
V
L
E
Y
A
N
R
L
A
V
L
Q
E
E
V
A
D
R
I
F
M
V
M
R
VYTAKPRTNGDGYK
G
L
IHQPNATE
A
P
S
L
I
N
G
I
K
A
V
R
H
L
H
Y
R
V
I
TETGMTT
A
D
EMLYPENLP
L
V
D
D
L
I
S
Y
M
A
VGARSVED
Q
Q
H
R
F
V
ASGAGFSTGFKNPTSGN
L
N
V
M
F
N
G
I
Y
AAQNK
Q
S
F
L
-----
F
-----LG-----KE-----VETTGN
P
L
S
H
A
I
L
R
G
A
L
N
E
Y
GKNI
P
N
Y
Y
Y
D
N
L
I
D
T
I
A
Q
Y
E
K
MGLEN
P
F
I
I
I
DTNHDN
S
G
K
Q
Y
I
E
Q
I
R
I
V
R
Q
T
L
I
N
R
A
W
N
E
K
I
---
K
Q
F
V
R
G
F
M
I
E
S
Y
L
EDGRQN
E
P
----
E
----
V
FGKSITDPCLGWD
N
T
E
A
L
V
R
E
I
Y
K
T
LGE---
120
HHSearch
92.55
35%
-18
- C5 -
-
1N8F
1
AROG_ECOLI
A:
[8-347]
L
R
I
K
E
I
K
E
L
L
P
P
V
A
L
L
Q
K
F
P
A
T
E
N
A
A
N
T
V
A
H
A
R
K
A
I
H
K
I
L
K
G
N
D
D
R
L
L
V
V
I
G
P
C
S
I
H
D
P
V
A
A
K
E
Y
A
T
R
L
L
A
L
R
E
E
L
K
D
E
L
E
I
V
M
R
V
Y
F
E
K
P
R
T
T
-
V
G
W
K
G
L
I
N
D
P
H
M
D
N
S
F
Q
I
N
D
G
L
R
I
A
R
K
L
L
L
-
D
I
N
D
S
G
L
P
A
A
G
E
F
L
D
M
I
T
P
Q
Y
L
A
D
L
M
S
W
G
A
I
G
A
R
T
T
E
S
Q
V
H
R
E
L
A
S
G
L
S
C
P
V
G
F
K
N
G
T
D
G
T
I
K
V
A
I
D
A
I
N
A
A
G
A
P
H
C
F
L
-----
S
V
T
KWG
H
S
-----
A
I
-----
V
N
T
S
G
N
G
D
C
H
I
I
L
R
G
-----
G
K
-
E
P
N
Y
S
A
K
H
V
A
E
V
K
E
G
L
N
K
A
G
-
L
P
A
Q
V
M
I
D
F
S
H
A
N
S
S
K
Q
F
K
K
Q
M
D
V
C
A
D
V
C
Q
Q
I
A
G
---
G
---
E
K
A
I
I
G
V
M
V
E
S
H
L
V
E
G
N
Q
S
L
E
SGEP
L
----
A
Y
G
K
S
I
T
D
A
C
I
G
W
E
D
T
D
A
L
L
R
Q
L
A
N
A
V
K
A
---
117
HHSearch
91.06
35%
-20
- C5 -
-
5D04
7
?
D:
[10-345]
I
K
I
K
E
V
K
E
L
L
P
P
I
A
H
L
Y
E
L
P
I
S
K
E
A
S
G
L
V
H
R
T
R
Q
E
I
S
D
L
V
H
G
R
D
K
R
L
L
V
I
I
G
P
C
S
I
H
D
P
K
A
A
L
E
Y
A
E
R
L
L
K
L
R
K
Q
Y
E
N
E
L
L
I
V
M
R
V
Y
F
E
K
P
R
T
T
V
-
G
W
K
G
L
I
N
D
P
H
L
D
G
T
F
D
I
N
F
G
L
R
Q
A
R
S
L
L
L
-
S
L
N
N
M
G
M
P
A
S
T
E
F
L
D
M
I
T
P
Q
Y
Y
A
D
L
I
S
W
G
A
I
G
A
R
T
T
E
S
Q
V
H
R
E
L
A
S
G
L
S
C
P
V
G
F
K
N
G
T
D
G
N
L
K
I
A
I
D
A
I
G
A
A
S
H
S
H
H
F
L
-----
S
VTKAG
H
S
-----
A
I
-----
A
H
T
G
G
N
P
D
C
H
V
I
L
R
G
-----
G
-
K
E
P
N
Y
D
A
E
H
V
S
E
A
A
E
Q
L
R
A
A
G
-
V
T
D
K
L
M
I
D
C
S
H
A
N
S
R
K
D
Y
T
R
Q
M
E
V
A
Q
D
I
A
A
Q
L
E
Q
---
D
---
G
G
N
I
M
G
V
M
V
E
S
H
L
V
E
G
R
Q
D
K
P
----
E
----
V
Y
G
K
S
I
T
D
A
C
I
G
W
G
A
T
E
E
L
L
A
L
L
A
G
A
N
K
K
---
134
Fugue
90.98
35%
-18
- C5 -
-
1QR7
1
AROG_ECOLI
A:
[8-350]
L
R
I
K
E
I
K
E
L
L
P
P
V
A
L
L
E
K
F
P
A
T
E
N
A
A
N
T
V
A
H
A
R
K
A
I
H
K
I
L
K
G
N
D
D
R
L
L
V
V
I
G
P
C
S
I
H
D
P
V
A
A
K
E
Y
A
T
R
L
L
A
L
R
E
E
L
K
D
E
L
E
I
V
M
R
V
Y
F
E
K
P
R
T
T
-
V
G
W
K
G
L
I
N
D
P
H
M
D
N
S
F
Q
I
N
D
G
L
R
I
A
R
K
L
L
L
D
I
N
D
-
S
G
L
P
A
A
G
E
F
L
D
M
I
T
P
Q
Y
L
A
D
L
M
S
W
G
A
I
G
A
R
T
T
E
S
Q
V
H
R
E
L
A
S
G
L
S
C
P
V
G
F
K
N
G
T
D
G
T
I
K
V
A
I
D
A
I
N
A
A
G
A
P
H
C
F
L
-----
S
-----
V
T
KWG
H
S
A
I
-----
V
N
T
S
G
N
G
D
C
H
I
I
L
R
G
G
K
E
------
P
N
Y
S
A
K
H
V
A
E
V
K
E
G
L
N
K
A
G
L
-
P
A
Q
V
M
I
D
F
S
H
A
N
S
S
K
Q
F
K
K
Q
M
D
V
C
A
D
V
C
Q
Q
I
A
G
G
E
K
------
A
I
I
G
V
M
V
E
S
H
L
V
E
G
N
Q
S
L
L
----
A
-----
Y
G
K
S
I
T
D
A
C
I
G
W
E
D
T
D
A
L
L
R
Q
L
A
N
A
V
K
A
R
R
G
118
HHSearch
90.64
35%
-22
- C5 -
-
5DCB
2
?
C:
[10-345]
I
K
I
K
E
V
K
E
L
L
P
P
I
A
H
L
Y
E
L
P
I
S
K
E
A
S
G
L
V
H
R
T
R
Q
E
I
S
D
L
V
H
G
R
D
K
R
L
L
V
I
I
G
P
C
S
I
H
D
P
K
A
A
L
E
Y
A
E
R
L
L
K
L
R
K
Q
Y
E
N
E
L
L
I
V
M
R
V
Y
F
E
K
P
R
T
T
V
-
G
W
K
G
L
I
N
D
P
H
L
D
G
T
F
D
I
N
F
G
L
R
Q
A
R
S
L
L
L
-
S
L
N
N
M
G
M
P
A
S
T
E
F
L
D
M
I
T
P
Q
Y
Y
A
D
L
I
S
W
G
A
I
G
A
R
T
T
E
S
Q
V
H
R
E
L
A
S
G
L
S
C
P
V
G
F
K
N
G
T
D
G
N
L
K
I
A
I
D
A
I
G
A
A
S
H
S
H
H
F
L
-----
S
VTKAG
H
S
-----
A
I
-----
V
H
T
G
G
N
P
D
C
H
V
I
L
R
G
-----
G
-
K
E
P
N
Y
D
A
E
H
V
S
E
A
A
E
Q
L
R
A
A
G
-
V
T
D
K
L
M
I
D
C
S
H
A
N
S
R
K
D
Y
T
R
Q
M
E
V
A
Q
D
I
A
A
Q
L
E
Q
---
D
---
G
G
N
I
M
G
V
M
V
E
S
H
L
V
E
G
R
Q
D
K
P
----
E
----
V
Y
G
K
S
I
T
D
A
C
I
G
W
G
A
T
E
E
L
L
A
L
L
A
G
A
N
K
K
---
116
HHSearch
89.79
35%
-17
- C5 -
-
1KFL
-
AROG_ECOLI
F:
[8-346]
L
R
I
K
E
I
K
E
L
L
P
P
V
A
L
L
E
K
F
P
A
T
E
N
A
A
N
T
V
A
H
A
R
K
A
I
H
K
I
L
K
G
N
D
D
R
L
L
V
V
I
G
P
C
S
I
H
D
P
V
A
A
K
E
Y
A
T
R
L
L
A
L
R
E
E
L
K
D
E
L
E
I
V
M
R
V
Y
F
E
K
P
R
T
T
-
V
G
W
K
G
L
I
N
D
P
H
M
D
N
S
F
Q
I
N
D
G
L
R
I
A
R
K
L
L
L
-
D
I
N
D
S
G
L
P
A
A
G
E
F
L
D
M
I
T
P
Q
Y
L
A
D
L
M
S
W
G
A
I
G
A
R
T
T
E
S
Q
V
H
R
E
L
A
S
G
L
S
C
P
V
G
F
K
N
G
T
D
G
T
I
K
V
A
I
D
A
I
N
A
A
G
A
P
H
C
F
L
-----
S
VTKWG
H
S
-----
A
I
-----
V
N
T
S
G
N
G
D
C
H
I
I
L
R
G
-----
G
K
-
E
P
N
Y
S
A
K
H
V
A
E
V
K
E
G
L
N
K
A
G
-
L
P
A
Q
V
M
I
D
F
S
H
A
N
S
S
K
Q
F
K
K
Q
M
D
V
C
A
D
V
C
Q
Q
I
A
G
---
G
---
E
K
A
I
I
G
V
M
V
E
S
H
L
V
E
G
N
Q
S
L
E
SGEP
L
----
A
Y
G
K
S
I
T
D
A
C
I
G
W
E
D
T
D
A
L
L
R
Q
L
A
N
A
V
K
----
115
HHSearch
88.30
33%
-6
- C5 -
-
1OF8
4
AROG_YEAST
B:
[23-362]
V
R
I
L
G
Y
D
P
L
A
S
P
A
L
L
Q
V
Q
I
P
A
T
P
T
S
L
E
T
A
K
R
G
R
R
E
A
I
D
I
I
T
G
K
D
D
R
V
L
V
I
V
G
P
C
S
I
H
D
L
E
A
A
Q
E
Y
A
L
R
L
K
K
L
S
D
E
L
K
G
D
L
S
I
I
M
R
A
Y
L
E
K
P
R
T
T
V
-
G
W
K
G
L
I
N
D
P
D
V
N
N
T
F
N
I
N
K
G
L
Q
S
A
R
Q
L
F
V
-
N
L
T
N
I
G
L
P
I
G
S
E
M
L
D
T
I
S
P
Q
Y
L
A
D
L
V
S
F
G
A
I
G
A
R
T
T
E
S
Q
L
H
R
E
L
A
S
G
L
S
F
P
V
G
F
K
N
G
T
D
G
T
L
N
V
A
V
D
A
C
Q
A
A
A
H
S
H
H
F
M
-----
G
VTKHG
V
A
-----
A
I
-----
T
T
T
K
G
N
E
H
C
F
V
I
L
R
G
-----
G
K
K
G
T
N
Y
D
A
K
S
V
A
E
A
K
A
Q
L
P
A
---
G
S
N
G
L
M
I
D
Y
S
H
G
N
S
N
K
D
F
R
N
Q
P
K
V
N
D
V
V
C
E
Q
I
A
N
G
------
E
N
A
I
T
G
V
M
I
E
S
N
I
N
E
G
N
Q
G
I
P
KAG-
L
----
K
Y
G
V
S
I
T
D
A
C
I
G
W
E
T
T
E
D
V
L
R
K
L
A
A
A
V
R
----
34
PsiBlast_CBE
88.11
39%
-19
- C5 -
-
5DCE
1
?
C:
[43-336]
---------------------------------
Q
E
I
S
D
L
V
H
G
R
D
K
R
L
L
V
I
I
G
P
C
S
I
H
D
P
K
A
A
L
E
Y
A
E
R
L
L
K
L
R
K
Q
Y
E
N
E
L
L
I
V
M
R
V
Y
F
E
K
P
R
T
T
-
V
G
W
K
G
L
I
N
D
P
H
L
D
G
T
F
D
I
N
F
G
L
R
Q
A
R
S
L
-
L
L
S
L
N
N
M
G
M
P
A
S
T
E
F
L
D
M
I
T
P
Q
Y
Y
A
D
L
I
S
W
G
A
I
G
A
R
T
T
E
S
Q
V
H
R
E
L
A
S
G
L
S
C
P
V
G
F
K
N
G
T
D
G
N
L
K
I
A
I
D
A
I
G
A
A
S
H
S
H
H
F
L
-----
S
-----
V
T
-----
K
A
G
H
S
A
I
V
H
T
G
G
N
P
D
C
H
V
I
L
R
G
-----
G
K
E
-
P
N
Y
D
A
E
H
V
S
E
A
A
E
Q
L
R
A
A
G
V
T
D
K
-
L
M
I
D
C
S
H
A
N
S
R
K
D
Y
T
R
Q
M
E
V
A
Q
D
I
---
A
A
Q
L
E
Q
D
---
G
G
N
I
M
G
V
M
V
E
S
H
L
V
E
G
R
Q
D
K
P
----
E
----
V
Y
G
K
S
I
T
D
A
C
I
G
W
G
A
T
E
E
L
L
------------
31
PsiBlast_CBE
87.82
39%
-21
- C5 -
-
5D02
3
?
C:
[43-336]
---------------------------------
Q
E
I
S
D
L
V
H
G
R
D
K
R
L
L
V
I
I
G
P
C
S
I
H
D
P
K
A
A
L
E
Y
A
E
R
L
L
K
L
R
K
Q
Y
E
N
E
L
L
I
V
M
R
V
Y
F
E
K
P
R
T
T
-
V
-
W
K
G
L
I
N
D
P
H
L
D
G
T
F
D
I
N
F
G
L
R
Q
A
R
S
L
-
L
L
S
L
N
N
M
G
M
P
A
S
T
E
F
L
D
M
I
T
P
Q
Y
Y
A
D
L
I
S
W
G
A
I
G
A
R
T
T
E
S
Q
V
H
R
Q
L
A
S
G
L
S
C
P
V
G
F
K
N
G
T
D
G
N
L
K
I
A
I
D
A
I
G
A
A
S
H
S
H
H
F
L
-----
S
-----
V
T
-----
K
A
G
H
S
A
I
V
H
T
G
G
N
P
D
C
H
V
I
L
R
G
-----
G
K
E
-
P
N
Y
D
A
E
H
V
S
E
A
A
E
Q
L
R
A
A
G
V
T
D
K
-
L
M
I
D
C
S
H
A
N
S
R
K
D
Y
T
R
Q
M
E
V
A
Q
D
I
---
A
A
Q
L
E
Q
D
---
G
G
N
I
M
G
V
M
V
E
S
H
L
V
E
G
R
Q
D
K
P
----
E
----
V
Y
G
K
S
I
T
D
A
C
I
G
W
G
A
T
E
E
L
L
------------
49
PsiBlast_CBE
87.58
39%
-19
- C5 -
-
4UMA
1
?
C:
[43-336]
---------------------------------
Q
E
I
S
D
L
V
H
G
R
D
K
R
L
L
V
I
I
G
P
C
S
I
H
D
P
K
A
A
L
E
Y
A
E
R
L
L
K
L
R
K
Q
Y
E
N
E
L
L
I
V
M
R
V
Y
F
E
K
P
R
T
T
-
V
G
W
K
G
L
I
N
D
P
H
L
D
G
T
F
D
I
N
F
G
L
R
Q
A
R
S
L
-
L
L
S
L
N
N
M
G
M
P
A
S
T
E
F
L
D
M
I
T
P
Q
Y
Y
A
D
L
I
S
W
G
A
I
G
A
R
T
T
E
S
Q
V
H
R
E
L
A
S
G
L
S
C
P
V
G
F
K
N
G
T
D
G
N
L
K
I
A
I
D
A
I
G
A
A
S
H
S
H
H
F
L
-----
S
-----
V
T
-----
K
A
GHSAI
V
H
T
G
G
N
P
D
C
H
V
I
L
R
G
-----
G
K
E
-
P
N
Y
D
A
E
H
V
S
E
A
A
E
Q
L
R
A
A
G
V
T
D
K
-
L
M
I
D
C
S
H
A
N
S
R
K
D
Y
T
R
Q
M
E
V
A
Q
D
I
---
A
A
Q
L
E
Q
D
---
G
G
N
I
M
G
V
M
V
E
S
H
L
V
E
G
R
Q
D
K
P
----
E
----
V
Y
G
K
S
I
T
D
A
C
I
G
W
G
A
T
E
E
L
L
------------
47
PsiBlast_CBE
87.53
39%
-15
- C5 -
-
4UMB
1
?
B:
[43-336]
---------------------------------
Q
E
I
S
D
L
V
H
G
R
D
K
R
L
L
V
I
I
G
P
C
S
I
H
D
P
K
A
A
L
E
Y
A
E
R
L
L
K
L
R
K
Q
Y
E
N
E
L
L
I
V
M
R
V
Y
F
E
K
P
R
T
T
-
V
G
W
K
G
L
I
N
D
P
H
L
D
G
T
F
D
I
N
F
G
L
R
Q
A
R
S
L
-
L
L
S
L
N
N
M
G
M
P
A
S
T
E
F
L
D
M
I
T
P
Q
Y
Y
A
D
L
I
S
W
G
A
I
G
A
R
T
T
E
S
Q
V
H
R
E
L
A
S
G
L
S
C
P
V
G
F
K
N
G
T
D
G
N
L
K
I
A
I
D
A
I
G
A
A
S
H
S
H
H
F
L
-----
S
-----
V
T
-----
K
A
G
H
S
A
I
V
H
T
G
G
N
P
D
C
H
V
I
L
R
G
-----
G
K
E
-
P
N
Y
D
A
E
H
V
S
E
A
A
E
Q
L
R
A
A
G
V
T
D
K
-
L
M
I
D
C
S
H
A
N
S
R
K
D
Y
T
R
Q
M
E
V
A
Q
D
I
---
A
A
Q
L
E
Q
D
---
G
G
N
I
M
G
V
M
V
E
S
H
L
V
E
G
R
Q
D
K
P
----
E
----
V
Y
G
K
S
I
T
D
A
C
I
G
W
G
A
T
E
E
L
L
------------
35
PsiBlast_CBE
87.44
39%
-23
- C5 -
-
5DCE
1
?
B:
[43-336]
---------------------------------
Q
E
I
S
D
L
V
H
G
R
D
K
R
L
L
V
I
I
G
P
C
S
I
H
D
P
K
A
A
L
E
Y
A
E
R
L
L
K
L
R
K
Q
Y
E
N
E
L
L
I
V
M
R
V
Y
F
E
K
P
R
T
T
-
V
G
W
K
G
L
I
N
D
P
H
L
D
G
T
F
D
I
N
F
G
L
R
Q
A
R
S
L
-
L
L
S
L
N
N
M
G
M
P
A
S
T
E
F
L
D
M
I
T
P
Q
Y
Y
A
D
L
I
S
W
G
A
I
G
A
R
T
T
E
S
Q
V
H
R
E
L
A
S
G
L
S
C
P
V
G
F
K
N
G
T
D
G
N
L
K
I
A
I
D
A
I
G
A
A
S
H
S
H
H
F
L
-----
S
-----
V
T
-----
K
A
G
H
S
A
I
V
H
T
G
G
N
P
D
C
H
V
I
L
R
G
-----
G
K
E
-
P
N
Y
D
A
E
H
V
S
E
A
A
E
Q
L
R
A
A
G
V
T
D
K
-
L
M
I
D
C
S
H
A
N
S
R
K
D
Y
T
R
Q
M
E
V
A
Q
D
I
---
A
A
Q
L
E
Q
D
---
G
G
N
I
M
G
V
M
V
E
S
H
L
V
E
G
R
Q
D
K
P
----
E
----
V
Y
G
K
S
I
T
D
A
C
I
G
W
G
A
T
E
E
L
L
------------
9
PsiBlast_PDB
87.37
39%
-22
- C5 -
-
4UC5
2
?
A:
[43-336]
---------------------------------
Q
E
I
S
D
L
V
H
G
R
D
K
R
L
L
V
I
I
G
P
C
S
I
H
D
P
K
A
A
L
E
Y
A
E
R
L
L
K
L
R
K
Q
Y
E
N
E
L
L
I
V
M
R
V
Y
F
E
K
P
R
T
T
-
V
G
W
K
G
L
I
N
D
P
H
L
D
G
T
F
D
I
N
F
G
L
R
Q
A
R
S
L
-
L
L
S
L
N
N
M
G
M
P
A
S
T
E
F
L
D
M
I
T
P
Q
Y
Y
A
D
L
I
S
W
G
A
I
G
A
R
T
T
E
S
Q
V
H
R
E
L
A
S
G
L
S
C
P
V
G
F
K
N
G
T
D
G
N
L
K
I
A
I
D
A
I
G
A
A
S
H
S
H
H
F
L
-----
S
-----
V
T
-----
K
A
G
H
S
A
I
V
H
T
G
G
N
P
D
C
H
V
I
L
R
G
-----
G
K
E
-
P
N
Y
D
A
E
H
V
S
E
A
A
E
Q
L
R
A
A
G
V
T
D
K
-
L
M
I
D
C
S
H
A
N
S
R
K
D
Y
T
R
Q
M
E
V
A
Q
D
I
---
A
A
Q
L
E
Q
D
---
G
G
N
I
M
G
V
M
V
E
S
H
L
V
E
G
R
Q
D
K
P
----
E
----
V
Y
G
K
S
I
T
D
A
C
I
G
W
G
A
T
E
E
L
L
------------
45
PsiBlast_CBE
87.36
39%
-17
- C5 -
-
4UMB
1
?
D:
[43-336]
---------------------------------
Q
E
I
S
D
L
V
H
G
R
D
K
R
L
L
V
I
I
G
P
C
S
I
H
D
P
K
A
A
L
E
Y
A
E
R
L
L
K
L
R
K
Q
Y
E
N
E
L
L
I
V
M
R
V
Y
F
E
K
P
R
T
T
-
V
G
W
K
G
L
I
N
D
P
H
L
D
G
T
F
D
I
N
F
G
L
R
Q
A
R
S
L
-
L
L
S
L
N
N
M
G
M
P
A
S
T
E
F
L
D
M
I
T
P
Q
Y
Y
A
D
L
I
S
W
G
A
I
G
A
R
T
T
E
S
Q
V
H
R
E
L
A
S
G
L
S
C
P
V
G
F
K
N
G
T
D
G
N
L
K
I
A
I
D
A
I
G
A
A
S
H
S
H
H
F
L
-----
S
-----
V
T
-----
K
A
GHSAI
V
H
T
G
G
N
P
D
C
H
V
I
L
R
G
-----
G
K
E
-
P
N
Y
D
A
E
H
V
S
E
A
A
E
Q
L
R
A
A
G
V
T
D
K
-
L
M
I
D
C
S
H
A
N
S
R
K
D
Y
T
R
Q
M
E
V
A
Q
D
I
---
A
A
Q
L
E
Q
D
---
G
G
N
I
M
G
V
M
V
E
S
H
L
V
E
G
R
Q
D
K
P
----
E
----
V
Y
G
K
S
I
T
D
A
C
I
G
W
G
A
T
E
E
L
L
------------
119
HHSearch
87.31
32%
-22
- C5 -
-
3TQK
-
?
A:
[6-342]
-
N
I
K
K
E
K
V
L
I
P
A
E
V
L
I
Q
D
I
P
L
L
K
T
S
F
E
T
V
R
K
S
R
K
E
I
A
N
I
I
H
G
N
D
D
R
V
A
V
V
V
G
P
C
S
I
H
D
P
A
A
A
I
E
Y
A
T
K
L
K
E
Q
V
K
K
F
H
K
D
I
L
I
I
M
R
V
Y
F
E
K
P
R
T
T
-
I
G
W
K
G
F
I
N
D
P
D
L
D
N
S
Y
N
I
N
K
G
L
R
L
A
R
N
L
L
S
-
D
L
T
N
M
G
L
P
C
A
T
E
F
L
D
V
I
T
P
Q
Y
F
A
E
L
I
T
W
G
A
I
G
A
R
T
V
E
S
Q
V
H
R
E
L
A
S
G
L
S
A
S
I
G
F
K
N
A
T
N
G
D
V
Q
V
A
V
D
A
V
K
S
A
T
Y
P
H
H
F
L
S
T
T
KS
G
-----
S
T
-----
A
I
-----
F
A
T
K
G
N
Q
N
G
H
V
I
L
R
G
-----
G
A
S
G
P
N
F
S
K
E
H
V
D
D
C
I
A
K
L
K
K
A
D
-
I
N
T
K
V
M
I
D
C
S
H
G
N
S
Q
K
D
H
S
K
Q
I
S
V
L
A
D
I
C
E
Q
I
K
H
-------
S
N
D
I
F
G
V
M
I
E
S
N
L
V
A
G
N
Q
D
I
N
KKP-
L
----
T
Y
G
Q
S
V
T
D
K
C
V
D
F
E
E
T
V
K
M
L
E
M
L
A
E
A
V
Q
----
27
PsiBlast_CBE
87.30
39%
-22
- C5 -
-
5CZT
1
?
D:
[43-336]
---------------------------------
Q
E
I
S
D
L
V
H
G
R
D
K
R
L
L
V
I
I
G
P
C
S
I
H
D
P
K
A
A
L
E
Y
A
E
R
L
L
K
L
R
K
Q
Y
E
N
E
L
L
I
V
M
R
V
Y
F
E
K
P
R
T
T
-
V
G
W
K
G
L
I
N
D
P
H
L
D
G
T
F
D
I
N
F
G
L
R
Q
A
R
S
L
-
L
L
S
L
N
N
M
G
M
P
A
S
T
E
F
L
D
M
I
T
P
Q
Y
Y
A
D
L
I
S
W
G
A
I
G
A
R
T
T
E
S
Q
V
H
R
A
L
A
S
G
L
S
C
P
V
G
F
K
N
G
T
D
G
N
L
K
I
A
I
D
A
I
G
A
A
S
H
S
H
H
F
L
-----
S
-----
V
T
-----
K
A
GHSAI
V
H
T
G
G
N
P
D
C
H
V
I
L
R
G
-----
G
K
E
-
P
N
Y
D
A
E
H
V
S
E
A
A
E
Q
L
R
A
A
G
V
T
D
K
-
L
M
I
D
C
S
H
A
N
S
R
K
D
Y
T
R
Q
M
E
V
A
Q
D
I
---
A
A
Q
L
E
Q
D
---
G
G
N
I
M
G
V
M
V
E
S
H
L
V
E
G
R
Q
D
K
P
----
E
----
V
Y
G
K
S
I
T
D
A
C
I
G
W
G
A
T
E
E
L
L
------------
61
PsiBlast_CBE
87.29
39%
-16
- C5 -
-
4HSO
2
?
C:
[43-336]
---------------------------------
Q
E
I
S
D
L
V
H
G
R
D
K
R
L
L
V
I
I
G
P
C
S
I
H
D
P
K
A
A
L
E
Y
A
E
R
L
L
K
L
R
K
Q
Y
E
N
E
L
L
I
V
M
R
V
Y
F
E
K
P
R
T
T
-
V
G
W
K
G
L
I
N
D
P
H
L
D
G
T
F
D
I
N
F
G
L
R
Q
A
R
S
L
-
L
L
S
L
N
N
M
G
M
P
A
S
T
E
F
L
D
M
I
T
P
Q
Y
Y
A
D
L
I
S
W
G
A
I
G
A
R
T
T
E
S
Q
V
H
R
E
L
A
S
G
L
S
C
P
V
G
F
K
N
G
T
D
G
N
L
K
I
A
I
D
A
I
G
A
A
S
H
S
H
H
F
L
-----
G
-----
V
T
-----
K
A
G
H
S
A
I
V
H
T
G
G
N
P
D
C
H
V
I
L
R
G
-----
G
K
E
-
P
N
Y
D
A
E
H
V
S
E
A
A
E
Q
L
R
A
A
G
V
T
D
K
-
L
M
I
D
C
S
H
A
N
S
R
K
D
Y
T
R
Q
M
E
V
A
Q
D
I
---
A
A
Q
L
E
Q
D
---
G
G
N
I
M
G
V
M
V
E
S
H
L
V
E
G
R
Q
D
K
P
----
E
----
V
Y
G
K
S
I
T
D
A
C
I
G
W
G
A
T
E
E
L
L
------------
33
PsiBlast_CBE
87.25
39%
-20
- C5 -
-
5DCE
1
?
D:
[43-336]
---------------------------------
Q
E
I
S
D
L
V
H
G
R
D
K
R
L
L
V
I
I
G
P
C
S
I
H
D
P
K
A
A
L
E
Y
A
E
R
L
L
K
L
R
K
Q
Y
E
N
E
L
L
I
V
M
R
V
Y
F
E
K
P
R
T
T
-
V
G
W
K
G
L
I
N
D
P
H
L
D
G
T
F
D
I
N
F
G
L
R
Q
A
R
S
L
-
L
L
S
L
N
N
M
G
M
P
A
S
T
E
F
L
D
M
I
T
P
Q
Y
Y
A
D
L
I
S
W
G
A
I
G
A
R
T
T
E
S
Q
V
H
R
E
L
A
S
G
L
S
C
P
V
G
F
K
N
G
T
D
G
N
L
K
I
A
I
D
A
I
G
A
A
S
H
S
H
H
F
L
-----
S
-----
V
T
-----
K
A
GHSAI
V
H
T
G
G
N
P
D
C
H
V
I
L
R
G
-----
G
K
E
-
P
N
Y
D
A
E
H
V
S
E
A
A
E
Q
L
R
A
A
G
V
T
D
K
-
L
M
I
D
C
S
H
A
N
S
R
K
D
Y
T
R
Q
M
E
V
A
Q
D
I
---
A
A
Q
L
E
Q
D
---
G
G
N
I
M
G
V
M
V
E
S
H
L
V
E
G
R
Q
D
K
P
----
E
----
V
Y
G
K
S
I
T
D
A
C
I
G
W
G
A
T
E
E
L
L
------------
36
PsiBlast_CBE
87.24
39%
-18
- C5 -
-
5DCD
2
?
D:
[43-336]
---------------------------------
Q
E
I
S
D
L
V
H
G
R
D
K
R
L
L
V
I
I
G
P
C
S
I
H
D
P
K
A
A
L
E
Y
A
E
R
L
L
K
L
R
K
Q
Y
E
N
E
L
L
I
V
M
R
V
Y
F
E
K
P
R
T
T
-
V
G
W
K
G
L
I
N
D
P
H
L
D
G
T
F
D
I
N
F
G
L
R
Q
A
R
S
L
-
L
L
S
L
N
N
M
G
M
P
A
S
T
E
F
L
D
M
I
T
P
Q
Y
Y
A
D
L
I
S
W
G
A
I
G
A
R
T
T
E
S
Q
V
H
R
E
L
A
S
G
L
S
C
P
V
G
F
K
N
G
T
D
G
N
L
K
I
A
I
D
A
I
G
A
A
S
H
S
H
H
F
L
-----
S
-----
V
T
-----
K
A
GHSAI
V
H
T
G
G
N
P
D
C
H
V
I
L
R
G
-----
G
K
E
-
P
N
Y
D
A
E
H
V
S
E
A
A
E
Q
L
R
A
A
G
V
T
D
K
-
L
M
I
D
C
S
H
A
N
S
R
K
D
Y
T
R
Q
M
E
V
A
Q
D
I
---
A
A
Q
L
E
Q
D
---
G
G
N
I
M
G
V
M
V
E
S
H
L
V
E
G
R
Q
D
K
P
----
E
----
V
Y
G
K
S
I
T
D
A
C
I
G
W
G
A
T
E
E
L
L
------------
3
PsiBlast_PDB
87.19
39%
-21
- C5 -
-
5CZT
1
?
A:
[43-336]
---------------------------------
Q
E
I
S
D
L
V
H
G
R
D
K
R
L
L
V
I
I
G
P
C
S
I
H
D
P
K
A
A
L
E
Y
A
E
R
L
L
K
L
R
K
Q
Y
E
N
E
L
L
I
V
M
R
V
Y
F
E
K
P
R
T
T
-
V
G
W
K
G
L
I
N
D
P
H
L
D
G
T
F
D
I
N
F
G
L
R
Q
A
R
S
L
-
L
L
S
L
N
N
M
G
M
P
A
S
T
E
F
L
D
M
I
T
P
Q
Y
Y
A
D
L
I
S
W
G
A
I
G
A
R
T
T
E
S
Q
V
H
R
A
L
A
S
G
L
S
C
P
V
G
F
K
N
G
T
D
G
N
L
K
I
A
I
D
A
I
G
A
A
S
H
S
H
H
F
L
-----
S
-----
V
T
-----
K
A
G
H
S
A
I
V
H
T
G
G
N
P
D
C
H
V
I
L
R
G
-----
G
K
E
-
P
N
Y
D
A
E
H
V
S
E
A
A
E
Q
L
R
A
A
G
V
T
D
K
-
L
M
I
D
C
S
H
A
N
S
R
K
D
Y
T
R
Q
M
E
V
A
Q
D
I
---
A
A
Q
L
E
Q
D
---
G
G
N
I
M
G
V
M
V
E
S
H
L
V
E
G
R
Q
D
K
P
----
E
----
V
Y
G
K
S
I
T
D
A
C
I
G
W
G
A
T
E
E
L
L
------------
28
PsiBlast_CBE
87.16
39%
-23
- C5 -
-
5CZT
1
?
C:
[43-336]
---------------------------------
Q
E
I
S
D
L
V
H
G
R
D
K
R
L
L
V
I
I
G
P
C
S
I
H
D
P
K
A
A
L
E
Y
A
E
R
L
L
K
L
R
K
Q
Y
E
N
E
L
L
I
V
M
R
V
Y
F
E
K
P
R
T
T
-
V
G
W
K
G
L
I
N
D
P
H
L
D
G
T
F
D
I
N
F
G
L
R
Q
A
R
S
L
-
L
L
S
L
N
N
M
G
M
P
A
S
T
E
F
L
D
M
I
T
P
Q
Y
Y
A
D
L
I
S
W
G
A
I
G
A
R
T
T
E
S
Q
V
H
R
A
L
A
S
G
L
S
C
P
V
G
F
K
N
G
T
D
G
N
L
K
I
A
I
D
A
I
G
A
A
S
H
S
H
H
F
L
-----
S
-----
V
T
-----
K
A
GHSAI
V
H
T
G
G
N
P
D
C
H
V
I
L
R
G
-----
G
K
E
-
P
N
Y
D
A
E
H
V
S
E
A
A
E
Q
L
R
A
A
G
V
T
D
K
-
L
M
I
D
C
S
H
A
N
S
R
K
D
Y
T
R
Q
M
E
V
A
Q
D
I
---
A
A
Q
L
E
Q
D
---
G
G
N
I
M
G
V
M
V
E
S
H
L
V
E
G
R
Q
D
K
P
----
E
----
V
Y
G
K
S
I
T
D
A
C
I
G
W
G
A
T
E
E
L
L
------------
109
PsiBlast_CBE
83.66
34%
-4
- C5 -
-
1OFO
1
AROG_YEAST
A:
[47-357]
------------------------
S
L
E
T
A
K
R
G
R
R
E
A
I
D
I
I
T
G
K
D
D
R
V
L
V
I
V
G
P
C
S
I
H
D
L
E
A
A
Q
E
Y
A
L
R
L
K
K
L
S
D
E
L
K
G
D
L
S
I
I
M
R
A
Y
L
E
K
P
R
T
T
-
V
G
W
K
G
L
I
N
D
P
D
V
N
N
T
F
N
I
N
K
G
L
Q
S
A
R
Q
L
-
F
V
N
L
T
N
I
G
L
P
I
G
S
E
M
L
D
T
I
S
P
Q
Y
L
A
D
L
V
S
F
G
A
I
G
A
R
T
T
E
S
Q
L
H
R
E
L
A
S
G
L
S
F
P
V
G
F
K
N
G
T
D
G
T
L
N
V
A
V
D
A
C
Q
A
A
A
H
S
H
H
F
M
-----
G
-----
V
T
-----
K
H
G
V
A
A
I
T
T
T
K
G
N
E
H
C
F
V
I
L
R
G
-----
G
K
K
G
T
N
Y
D
A
K
S
V
A
E
A
K
A
Q
---
L
P
A
G
S
N
G
L
M
I
D
Y
S
H
G
N
S
N
K
D
F
R
N
Q
P
K
------
V
N
D
V
V
C
E
Q
I
A
N
G
E
N
A
I
T
G
V
M
I
E
S
N
I
N
E
G
N
Q
G
I
P
-----AGL-
K
Y
G
V
S
I
T
D
A
C
I
G
W
E
T
T
E
D
V
L
R
K
L
---------
112
PsiBlast_CBE
83.31
34%
-1
- C5 -
-
1OFA
3
AROG_YEAST
A:
[47-357]
------------------------
S
L
E
T
A
K
R
G
R
R
E
A
I
D
I
I
T
G
K
D
D
R
V
L
V
I
V
G
P
C
S
I
H
D
L
E
A
A
Q
E
Y
A
L
R
L
K
K
L
S
D
E
L
K
G
D
L
S
I
I
M
R
A
Y
L
E
K
P
R
T
T
-
V
G
W
K
G
L
I
N
D
P
D
V
N
N
T
F
N
I
N
K
G
L
Q
S
A
R
Q
L
-
F
V
N
L
T
N
I
G
L
P
I
G
S
E
M
L
D
T
I
S
P
Q
Y
L
A
D
L
V
S
F
G
A
I
G
A
R
T
T
E
S
Q
L
H
R
E
L
A
S
G
L
S
F
P
V
G
F
K
N
G
T
D
G
T
L
N
V
A
V
D
A
C
Q
A
A
A
H
S
H
H
F
M
-----
G
-----
V
T
-----
K
H
GVA
A
I
T
T
T
K
G
N
E
H
C
F
V
I
L
R
G
-----
G
K
K
G
T
N
Y
D
A
K
S
V
A
E
A
K
A
Q
---
L
P
A
G
S
N
G
L
M
I
D
Y
S
H
G
N
S
N
K
D
F
R
N
Q
P
K
------
V
N
D
V
V
C
E
Q
I
A
N
G
E
N
A
I
T
G
V
M
I
E
S
N
I
N
E
G
N
Q
G
I
P
-----AGL-
K
Y
G
V
S
I
T
D
A
C
I
G
W
E
T
T
E
D
V
L
R
K
L
---------
113
PsiBlast_CBE
82.91
34%
-3
- C5 -
-
1OF8
4
AROG_YEAST
B:
[47-357]
------------------------
S
L
E
T
A
K
R
G
R
R
E
A
I
D
I
I
T
G
K
D
D
R
V
L
V
I
V
G
P
C
S
I
H
D
L
E
A
A
Q
E
Y
A
L
R
L
K
K
L
S
D
E
L
K
G
D
L
S
I
I
M
R
A
Y
L
E
K
P
R
T
T
-
V
G
W
K
G
L
I
N
D
P
D
V
N
N
T
F
N
I
N
K
G
L
Q
S
A
R
Q
L
-
F
V
N
L
T
N
I
G
L
P
I
G
S
E
M
L
D
T
I
S
P
Q
Y
L
A
D
L
V
S
F
G
A
I
G
A
R
T
T
E
S
Q
L
H
R
E
L
A
S
G
L
S
F
P
V
G
F
K
N
G
T
D
G
T
L
N
V
A
V
D
A
C
Q
A
A
A
H
S
H
H
F
M
-----
G
-----
V
T
-----
K
H
GVAAI
T
T
T
K
G
N
E
H
C
F
V
I
L
R
G
-----
G
K
K
G
T
N
Y
D
A
K
S
V
A
E
A
K
A
Q
---
L
P
A
G
S
N
G
L
M
I
D
Y
S
H
G
N
S
N
K
D
F
R
N
Q
P
K
------
V
N
D
V
V
C
E
Q
I
ANG
E
N
A
I
T
G
V
M
I
E
S
N
I
N
E
G
N
Q
G
I
P
-----KAGL
K
Y
G
V
S
I
T
D
A
C
I
G
W
E
T
T
E
D
V
L
R
K
L
---------
111
PsiBlast_CBE
82.20
34%
-9
- C5 -
-
1OFA
4
AROG_YEAST
B:
[47-357]
------------------------
S
L
E
T
A
K
R
G
R
R
E
A
I
D
I
I
T
G
K
D
D
R
V
L
V
I
V
G
P
C
S
I
H
D
L
E
A
A
Q
E
Y
A
L
R
L
K
K
L
S
D
E
L
K
G
D
L
S
I
I
M
R
A
Y
L
E
K
P
R
T
T
-
V
G
W
K
G
L
I
N
D
P
D
V
N
N
T
F
N
I
N
K
G
L
Q
S
A
R
Q
L
-
F
V
N
L
T
N
I
G
L
P
I
G
S
E
M
L
D
T
I
S
P
Q
Y
L
A
D
L
V
S
F
G
A
I
G
A
R
T
T
E
S
Q
L
H
R
E
L
A
S
G
L
S
F
P
V
G
F
K
N
G
T
D
G
T
L
N
V
A
V
D
A
C
Q
A
A
A
H
S
H
H
F
M
-----
G
-----
V
T
-----
K
H
GVAAI
T
T
T
K
G
N
E
H
C
F
V
I
L
R
G
-----
G
K
K
G
T
N
Y
D
A
K
S
V
A
E
A
K
A
Q
---
L
P
A
G
S
N
G
L
M
I
D
Y
S
H
G
N
S
N
K
D
F
R
N
Q
P
K
------
V
N
D
V
V
C
E
Q
I
ANG
E
N
A
I
T
G
V
M
I
E
S
N
I
N
E
G
N
Q
G
-----------
K
Y
G
V
S
I
T
D
A
C
I
G
W
E
T
T
E
D
V
L
R
K
L
---------