@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : spr1544: (2018-01-14 )
MANILKTIIENDKGEIRRLEKMADKVFKYEDQMAALTDDQLKAKTVEFKERYQNGESLDSLLYEAFAVVREGAKRVLGLFPYKVQVMGGIVLHHGDVPEMRTGEGKTLTATMPVYLNALSGKGVHVVTVNEYLSERDATEMGELYSWLGLSVGINLATKSPMEKKEAYECDITYSTNSEIGFDYLRDNMVVRAENMVQRPLNYALVDEVDSILIDEARTPLIVSGANAVETSQLYHMADHYVKSLNKDDYIIDVQSKTIGLSDSGIDRAESYFKLENLYDIENVALTHFIDNALRANYIMLLDIDYVVSEEQEILIVDQFTGRTMEGRRYSDGLHQAIEAKEGVPIQDETKTSASITYQNLFRMYKKLSGMTGTGKTEEEEFREIYNIRVIPIPTNRPVQRIDHSDLLYASIESKFKAVVEDVKARYQKGQPVLVGTVAVETSDYISKKLVAAGVPHEVLNAKNHYREAQIIMNAGQRGAVTIATNMAGRGTDIKLGEGVRELGGLCVIGTERHESRRIDNQLRGRSGRQGDPGESQFYLSLEDDLMKRFGSERLKGIFERLNMSEEAIESRMLTRQVEAAQKRVEGNNHDTRKQVLQYDDVMREQREIIYAQRYDVITADRDLAPEIQAMIKRTIERVVDGHARAKQDEKLEAILNFAKYNLLPEDSITMEDLSGLSDKAIKEELFQRALKVYDSQVSKLRDEEAVKEFQKVLILRVVDNKWTDHIDALDQLRNAVGLRGYAQNNPVVEYQAEGFRMFNDMIGSIEFDVTRLMMKAQIHEQERPQAERHISTTATRNIAAHQASMPEDLDLNQIGRNELCPCGSGKKFKNCHGKRQ
Atome Classification :
(25 SA)
.........10.........20-........30........40........50...---.....60........70........80........90........100.......110.......120.......130.......140.......150..---------------.....--------------------------------------------------160.-----------------------------------......170.......180.......190.......---200.......210.......220.......230.......240.------------..---.------------.-.-.---------250.......260.......270.-------..-------....280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450--------------------------------------------------------------------------.........460.......470.......480.......490.....------------------------------------------------------------------.--------------------------------------------.-----------------------------500.......510.......520.......530.......540.......550.......560....-..-.570.......580.......590.......600.......610.......-620.......630.......640..---.--.---...650--........660---...-.----.....670.......680.......690.......700---........710.......720.......730...--------------....740----------------------------.......750.......760.......770.......------780.......790.......800.......810.......820.......830.....
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
M
A
N
I
L
K
T
I
I
E-ND
K
G
E
I
R
R
L
E
K
-
M
A
D
K
V
F
K
Y
E
D
Q
M
A
ALTD
D
Q
LK
A
K
T
V
E
F
K
E
R
YQN---G
E
S
L
D
S
L
L
Y
E
A
F
A
V
V
R
E
G
A
K
R
V
L
GLF
P
Y
K
V
Q
V
M
G
G
I
V
L
HHGDVPEMRTGEG
K
T
L
T
A
TM
P
V
Y
L
NALSGK
G
V
H
V
V
T
V
N
E
Y
LSERD
A
T
E
M
G
E
L
Y
S
W
L
G
L
S
V
G
I
---------------NLATK--------------------------------------------------SPME-----------------------------------KKE
A
Y
E
C
D
I
T
Y
STNSE
I
G
F
D
Y
L
RDN
M
V
V
R
A
E
N
M
V
QR---PL
N
Y
A
L
V
D
E
V
D
S
I
L
IDEART
P
L
I
VSGANAV
E
T
S
Q
L
Y
H
M
A
D
H
Y
V
K
------------SL---N------------K-D-
D
---------
Y
I
I
D
V
QS
K
T
IGLSDSG
I
D
R
A
E
S
Y
F
-------
K
L
-------
E
N
LY
D
I
E
N
V
A
L
T
H
F
I
D
N
A
LRA
N
Y
I
M
L
L
D
I
D
Y
VVSEE
Q
E
I
L
I
V
DQFTGRTMEGRRY
S
D
G
L
H
Q
A
I
E
AKEGVPIQDETKTS
A
S
I
T
Y
Q
N
L
F
R
M
Y
K
K
LSGMTGTGKT
E
E
E
E
F
R
E
IY
N
I
R
V
I
PIPTNRPVQRIDH
S
D
L
L
Y
A
S
I
E
S
K
F
K
A
V
V
E
D
V
K
A
R
YQKGQ
P
V
L
V
G
T
V
A
VE
T
S
D
Y
I
S
K
K
L
----------------------------------------------------------------------------
V
AAGV
P
H
E
V
L
N
AKNH
Y
R
E
A
Q
I
I
M
NAGQR
G
A
V
T
I
A
TNMAGRGTDI
K
L
G
------------------------------------------------------------------
E
--------------------------------------------
G
-----------------------------
V
R
E
LG
G
L
C
V
IGTER
H
E
S
R
R
I
D
N
Q
LRGRSGRQGDPGE
S
Q
F
Y
L
SL
E
D
D
L
M
K
R
F
G
S
E
R
L
K
G
I
F
E
RLNM
S
E
-
E
A
-
I
E
S
R
M
L
T
R
Q
V
E
A
A
Q
K
RVEGNN
H
D
T
R
K
Q
V
L
Q
Y
D
D
V
M
R
E
Q
R
E
I
I
Y
A
Q
R
Y
D
V
I
T-ADRDL
A
P
E
I
Q
A
M
I
K
R
T
I
E
R
V
VDGHA---R--A---
K
Q
D
E
K
---
L
E
A
I
L
N
F
A
K
-----YNL-L----PEDSI
T
M
E
D
LSGLS
D
K
A
I
K
E
E
L
F
Q
R
A
L
K
V
Y
D
S
Q
V
S
K
L----R
D
E
E
A
V
K
E
F
Q
K
V
L
I
L
R
VVDNKWT
D
H
I
D
A
L
D
Q
L
R
N
--------------
A
VGLRGY----------------------------AQNN
P
V
V
E
Y
Q
A
E
G
F
R
M
F
N
D
M
IGS
I
E
F
D
V
T
R
L
M
M
K
A
Q
I------HEQER
P
Q
A
E
RHISTTATRNIAAHQASMPEDL
D
L
N
QIGRNELCPCGSGK
K
F
K
N
CHGKRQ
10
PsiBlast_PDB
80.02
54%
-32
- C4 -
-
5EUL
19
SECA_BACSU
A:
[14-825]
--------------
R
T
L
N
R
Y
E
K
-
I
A
N
D
I
D
A
I
R
G
D
Y
E
N
L
S
D
D
A
L
K
H
K
T
I
E
F
K
E
R
L
E
K
---
G
A
T
T
D
D
L
L
V
E
A
F
A
V
V
R
E
A
S
R
R
V
T
G
M
F
P
F
K
V
Q
L
M
G
G
V
A
L
H
D
G
N
I
A
E
M
K
T
G
E
G
K
T
L
T
S
T
L
P
V
Y
L
N
A
L
T
G
K
G
V
H
V
V
T
V
N
E
Y
L
A
S
R
D
A
E
Q
M
G
K
I
F
E
F
L
G
L
T
V
G
L
---------------
N
L
N
S
M
--------------------------------------------------
S
K
D
E
-----------------------------------
K
R
E
A
Y
A
A
D
I
T
Y
S
T
N
N
E
L
G
F
D
Y
L
R
D
N
M
V
L
Y
K
E
Q
M
V
Q
R
---
P
L
H
F
A
V
I
D
E
V
D
S
I
L
I
D
E
A
R
T
P
L
I
I
S
G
-
Q
A
A
K
S
T
K
L
Y
V
Q
A
N
A
F
V
R
------------
T
L
---
K
--------------------------
Y
T
Y
D
I
K
T
K
A
V
Q
L
T
E
E
G
M
T
K
A
E
K
A
F
-------
G
I
-------
D
N
L
F
D
V
K
H
V
A
L
N
H
H
I
N
Q
A
L
K
A
H
V
A
M
Q
K
D
V
D
Y
V
V
-
E
D
G
Q
V
V
I
V
D
S
F
T
G
R
L
M
K
G
R
R
Y
S
E
G
L
H
Q
A
I
E
A
K
E
G
L
E
I
Q
N
E
S
M
T
L
A
T
I
T
F
Q
N
Y
F
R
M
Y
E
K
L
A
G
M
T
G
T
A
K
T
E
E
E
E
F
R
N
I
Y
N
M
Q
V
V
T
I
P
T
N
R
P
V
V
R
D
D
R
P
D
L
I
Y
R
T
M
E
G
K
F
K
A
V
A
E
D
V
A
Q
R
Y
M
T
G
Q
P
V
L
V
G
T
V
A
V
E
T
S
E
L
I
S
K
L
L
----------------------------------------------------------------------------
K
N
K
G
I
P
H
Q
V
L
N
A
K
N
H
E
R
E
A
Q
I
I
E
E
A
G
Q
K
G
A
V
T
I
A
T
N
M
A
G
--
T
D
I
K
L
G
------------------------------------------------------------------
E
--------------------------------------------
G
-----------------------------
V
K
E
L
G
G
L
A
V
V
G
T
E
R
H
E
S
R
R
I
D
N
Q
L
R
G
R
S
G
R
Q
G
D
P
G
I
T
Q
F
Y
L
S
M
E
D
E
L
M
R
R
F
G
A
E
R
T
M
A
M
L
D
R
F
G
M
D
D
-
S
T
P
I
Q
S
K
M
V
S
R
A
V
E
S
S
Q
K
R
V
E
G
N
N
F
D
S
R
K
Q
L
L
Q
Y
D
D
V
L
R
Q
Q
R
E
V
I
Y
K
Q
R
F
E
V
I
D
-------
E
I
V
E
N
M
I
K
S
S
L
E
R
A
I
A
A
Y
-----------------------------------------------------------
M
L
E
L
I
M
D
R
I
I
T
K
Y
N
E
----------
K
E
Q
-
M
R
E
F
E
K
V
I
V
L
R
A
V
D
S
K
W
M
D
H
I
D
A
M
D
Q
L
R
Q
G
IHLRGSKKTA
I
A
I
A
V
A
L
A
G
F
A
T
V
ASYAQYEDGCSGELERQHTFAGGPG
A
---
P
L
R
E
Y
Q
M
E
G
F
A
M
F
E
H
M
I
E
S
I
E
D
E
V
A
K
F
V
M
K
A
------------------------------------------------------------------
2
PsiBlast_PDB
79.49
55%
10
- C4 -
-
1TF5
-
SECA_BACSU
A:
[1-780]
M
L
G
I
L
N
-------
K
R
T
L
N
R
Y
E
K
-
I
A
N
D
I
D
A
I
R
G
D
Y
E
N
L
S
D
D
A
L
K
H
K
T
I
E
F
K
E
R
L
E
K
---
G
A
T
T
D
D
L
L
V
E
A
F
A
V
V
R
E
A
S
R
R
V
T
G
M
F
P
F
K
V
Q
L
M
G
G
V
A
L
H
D
G
N
I
A
E
M
K
T
G
E
G
K
T
L
T
S
T
L
P
V
Y
L
N
A
L
T
G
K
G
V
H
V
V
T
V
N
E
Y
L
A
S
R
D
A
E
Q
M
G
K
I
F
E
F
L
G
L
T
V
G
L
---------------
N
L
N
S
M
--------------------------------------------------
S
K
D
E
-----------------------------------
K
R
E
A
Y
A
A
D
I
T
Y
S
T
N
N
E
L
G
F
D
Y
L
R
D
N
M
V
L
Y
K
E
Q
M
V
Q
R
---
P
L
H
F
A
V
I
D
E
V
D
S
I
L
I
D
E
A
R
T
P
L
I
I
S
G
-
Q
A
A
K
S
T
K
L
Y
V
Q
A
N
A
F
V
R
------------
T
L
---
K
------------
A
-
E
K
D
---------
Y
T
Y
D
I
K
T
K
A
V
Q
L
T
E
E
G
M
T
K
A
E
K
A
F
-------
G
I
-------
D
N
L
F
D
V
K
H
V
A
L
N
H
H
I
N
Q
A
L
K
A
H
V
A
M
Q
K
D
V
D
Y
V
V
-
E
D
G
Q
V
V
I
V
D
S
F
T
G
R
L
M
K
G
R
R
Y
S
E
G
L
H
Q
A
I
E
A
K
E
G
L
E
I
Q
N
E
S
M
T
L
A
T
I
T
F
Q
N
Y
F
R
M
Y
E
K
L
A
G
M
T
G
T
A
K
T
E
E
E
E
F
R
N
I
Y
N
M
Q
V
V
T
I
P
T
N
R
P
V
V
R
D
D
R
P
D
L
I
Y
R
T
M
E
G
K
F
K
A
V
A
E
D
V
A
Q
R
Y
M
T
G
Q
P
V
L
V
G
T
V
A
V
E
T
S
E
L
I
S
K
L
L
----------------------------------------------------------------------------
K
N
K
G
I
P
H
Q
V
L
N
A
K
N
H
E
R
E
A
Q
I
I
E
E
A
G
Q
K
G
A
V
T
I
A
T
N
M
A
G
R
G
T
D
I
K
L
G
------------------------------------------------------------------
E
--------------------------------------------
G
-----------------------------
V
K
E
L
G
G
L
A
V
V
G
T
E
R
H
E
S
R
R
I
D
N
Q
L
R
G
R
S
G
R
Q
G
D
P
G
I
T
Q
F
Y
L
S
M
E
D
E
L
M
R
R
F
G
A
E
R
T
M
A
M
L
D
R
F
G
M
D
D
-
S
T
P
I
Q
S
K
M
V
S
R
A
V
E
S
S
Q
K
R
V
E
G
N
N
F
D
S
R
K
Q
L
L
Q
Y
D
D
V
L
R
Q
Q
R
E
V
I
Y
K
Q
R
F
E
V
I
D
-
S
E
-
N
L
R
E
I
V
E
N
M
I
K
S
S
L
E
R
A
I
A
A
Y
T
PRE
E
--
L
---
P
E
E
W
K
---
L
D
G
L
V
D
L
I
N
-----
T
T
Y
-
L
----
D
E
G
A
L
E
K
S
D
I
F
G
K
E
P
D
E
M
L
E
L
I
M
D
R
I
I
T
K
Y
N
E
K
E
E
Q
F
-----
G
K
E
Q
M
R
E
F
E
K
V
I
V
L
R
A
V
D
S
K
W
M
D
H
I
D
A
M
D
Q
L
R
Q
--------------
G
I
H
L
R
A
Y
----------------------------
A
Q
T
N
P
L
R
E
Y
Q
M
E
G
F
A
M
F
E
H
M
I
E
S
I
E
D
E
V
A
K
F
V
M
K
A
E
I
----------------------------------------------------------------
1
PsiBlast_PDB
79.02
55%
11
- C4 -
-
1TF2
1
SECA_BACSU
A:
[4-783]
M
L
G
I
L
N
-------
K
R
T
L
N
R
Y
E
K
-
I
A
N
D
I
D
A
I
R
G
D
Y
E
N
L
S
D
D
A
L
K
H
K
T
I
E
F
K
E
R
L
E
K
---
G
A
T
T
D
D
L
L
V
E
A
F
A
V
V
R
E
A
S
R
R
V
T
G
M
F
P
F
K
V
Q
L
M
G
G
V
A
L
H
D
G
N
I
A
E
M
K
T
G
E
G
K
T
L
T
S
T
L
P
V
Y
L
N
A
L
T
G
K
G
V
H
V
V
T
V
N
E
Y
L
A
S
R
D
A
E
Q
M
G
K
I
F
E
F
L
G
L
T
V
G
L
---------------
N
L
N
S
M
--------------------------------------------------
S
K
D
E
-----------------------------------
K
R
E
A
Y
A
A
D
I
T
Y
S
T
N
N
E
L
G
F
D
Y
L
R
D
N
M
V
L
Y
K
E
Q
M
V
Q
R
---
P
L
H
F
A
V
I
D
E
V
D
S
I
L
I
D
E
A
R
T
P
L
I
I
S
G
-
Q
A
A
K
S
T
K
L
Y
V
Q
A
N
A
F
V
R
------------
T
L
---
K
------------
A
-
E
K
D
---------
Y
T
Y
D
I
K
T
K
A
V
Q
L
T
E
E
G
M
T
K
A
E
K
A
F
-------
G
I
-------
D
N
L
F
D
V
K
H
V
A
L
N
H
H
I
N
Q
A
L
K
A
H
V
A
M
Q
K
D
V
D
Y
V
V
-
E
D
G
Q
V
V
I
V
D
S
F
T
G
R
L
M
K
G
R
R
Y
S
E
G
L
H
Q
A
I
E
A
K
E
G
L
E
I
Q
N
E
S
M
T
L
A
T
I
T
F
Q
N
Y
F
R
M
Y
E
K
L
A
G
M
T
G
T
A
K
T
E
E
E
E
F
R
N
I
Y
N
M
Q
V
V
T
I
P
T
N
R
P
V
V
R
D
D
R
P
D
L
I
Y
R
T
M
E
G
K
F
K
A
V
A
E
D
V
A
Q
R
Y
M
T
G
Q
P
V
L
V
G
T
V
A
V
E
T
S
E
L
I
S
K
L
L
----------------------------------------------------------------------------
K
N
K
G
I
P
H
Q
V
L
N
A
K
N
H
E
R
E
A
Q
I
I
E
E
A
G
Q
K
G
A
V
T
I
A
T
N
M
A
G
R
G
T
D
I
K
L
G
------------------------------------------------------------------
E
--------------------------------------------
G
-----------------------------
V
K
E
L
G
G
L
A
V
V
G
T
E
R
H
E
S
R
R
I
D
N
Q
L
R
G
R
S
G
R
Q
G
D
P
G
I
T
Q
F
Y
L
S
M
E
D
E
L
M
R
R
F
G
A
E
R
T
M
A
M
L
D
R
F
G
M
D
D
-
S
T
P
I
Q
S
K
M
V
S
R
A
V
E
S
S
Q
K
R
V
E
G
N
N
F
D
S
R
K
Q
L
L
Q
Y
D
D
V
L
R
Q
Q
R
E
V
I
Y
K
Q
R
F
E
V
I
D
-
S
E
-
N
L
R
E
I
V
E
N
M
I
K
S
S
L
E
R
A
I
A
A
Y
T
PRE--------
E
E
W
K
---
L
D
G
L
V
D
L
I
N
-----
T
T
Y
-
L
----
D
E
G
A
L
E
K
S
D
I
F
G
K
E
P
D
E
M
L
E
L
I
M
D
R
I
I
T
K
Y
N
E
K
E
E
Q
F
-----
G
K
E
Q
M
R
E
F
E
K
V
I
V
L
R
A
V
D
S
K
W
M
D
H
I
D
A
M
D
Q
L
R
Q
--------------
G
I
H
L
R
A
Y
----------------------------
A
Q
T
N
P
L
R
E
Y
Q
M
E
G
F
A
M
F
E
H
M
I
E
S
I
E
D
E
V
A
K
F
V
M
K
A
E
I
----------------------------------------------------------------
21
PsiBlast_CBE
78.86
57%
8
- C4 -
-
3JV2
1
SECA_BACSU
B:
[17-782]
--------------
R
T
L
N
R
Y
E
K
-
I
A
N
D
I
D
A
I
R
G
D
Y
E
N
L
S
D
D
A
L
K
H
K
T
I
E
F
K
E
R
L
E
K
---
G
A
T
T
D
D
L
L
V
E
A
F
A
V
V
R
E
A
S
R
R
V
T
G
M
F
P
F
K
V
Q
L
M
G
G
V
A
L
H
D
G
N
I
A
E
M
K
T
G
E
G
K
T
L
T
S
T
L
P
V
Y
L
N
A
L
T
G
K
G
V
H
V
V
T
V
N
E
Y
L
A
S
R
D
A
E
Q
M
G
K
I
F
E
F
L
G
L
T
V
G
L
---------------
N
L
N
S
M
--------------------------------------------------
S
K
D
E
-----------------------------------
K
R
E
A
Y
A
A
D
I
T
Y
S
T
N
N
E
L
G
F
D
Y
L
R
D
N
M
V
L
Y
K
E
Q
M
V
Q
R
---
P
L
H
F
A
V
I
D
E
V
D
S
I
L
I
D
E
A
R
T
P
L
I
I
S
G
-
Q
A
A
K
S
T
K
L
Y
V
Q
A
N
A
F
V
R
------------
T
L
---
K
------------
A
-
E
K
D
---------
Y
T
Y
D
I
K
T
K
A
V
Q
L
T
E
E
G
M
T
K
A
E
K
A
F
-------
G
I
-------
D
N
L
F
D
V
K
H
V
A
L
N
H
H
I
N
Q
A
L
K
A
H
V
A
M
Q
K
D
V
D
Y
V
V
-
E
D
G
Q
V
V
I
V
D
S
F
T
G
R
L
M
K
G
R
R
Y
S
E
G
L
H
Q
A
I
E
A
K
E
G
L
E
I
Q
N
E
S
M
T
L
A
T
I
T
F
Q
N
Y
F
R
M
Y
E
K
L
A
G
M
T
G
T
A
K
T
E
E
E
E
F
R
N
I
Y
N
M
Q
V
V
T
I
P
T
N
R
P
V
V
R
D
D
R
P
D
L
I
Y
R
T
M
E
G
K
F
K
A
V
A
E
D
V
A
Q
R
Y
M
T
G
Q
P
V
L
V
G
T
V
A
V
E
T
S
E
L
I
S
K
L
L
----------------------------------------------------------------------------
K
N
K
G
I
P
H
Q
V
L
N
A
K
N
H
E
R
E
A
Q
I
I
E
E
A
G
Q
K
G
A
V
T
I
A
T
N
M
A
G
R
G
T
D
I
K
L
G
------------------------------------------------------------------
E
--------------------------------------------
G
-----------------------------
V
K
E
L
G
G
L
A
V
V
G
T
E
R
H
E
S
R
R
I
D
N
Q
L
R
G
R
S
G
R
Q
G
D
P
G
I
T
Q
F
Y
L
S
M
E
D
E
L
M
R
R
F
G
A
E
R
T
M
A
M
L
D
R
F
G
M
D
D
-
S
T
P
I
Q
S
K
M
V
S
R
A
V
E
S
S
Q
K
R
V
E
G
N
N
F
D
S
R
K
Q
L
L
Q
Y
D
D
V
L
R
Q
Q
R
E
V
I
Y
K
Q
R
F
E
V
I
D
-
S
E
-
N
L
R
E
I
V
E
N
M
I
K
S
S
L
E
R
A
I
A
A
Y
T
PRE---------
E
W
K
---
L
D
G
L
V
D
L
I
N
-----
T
T
Y
-
L
----
D
E
G
A
L
E
K
S
D
I
F
G
K
E
P
D
E
M
L
E
L
I
M
D
R
I
I
T
K
Y
N
E
K
E
E
Q
F
-----
G
K
E
Q
M
R
E
F
E
K
V
I
V
L
R
A
V
D
S
K
W
M
D
H
I
D
A
M
D
Q
L
R
Q
--------------
G
I
H
L
R
A
Y
----------------------------
A
Q
T
N
P
L
R
E
Y
Q
M
E
G
F
A
M
F
E
H
M
I
E
S
I
E
D
E
V
A
K
F
V
M
K
A
E
-----------------------------------------------------------------
58
Fugue
78.55
56%
13
- C4 -
-
1M6N
-
SECA_BACSU
A:
[1-802]
M
L
G
I
L
N
K
M
F
D
-
P
T
K
R
T
L
N
R
Y
E
K
-
I
A
N
D
I
D
A
I
R
G
D
Y
E
N
L
S
D
D
A
L
K
H
K
T
I
E
F
K
E
R
L
E
K
---
G
A
T
T
D
D
L
L
V
E
A
F
A
V
V
R
E
A
S
R
R
V
T
G
M
F
P
F
K
V
Q
L
M
G
G
V
A
L
H
D
G
N
I
A
E
M
K
T
G
E
G
K
T
L
T
S
T
L
P
V
Y
L
N
A
L
T
G
K
G
V
H
V
V
T
V
N
E
Y
L
A
S
R
D
A
E
Q
M
G
K
I
F
E
F
L
G
L
T
V
G
L
---------------
N
L
N
S
M
--------------------------------------------------
S
K
D
E
-----------------------------------
K
R
E
A
Y
A
A
D
I
T
Y
S
T
N
N
E
L
G
F
D
Y
L
R
D
N
M
V
L
Y
K
E
Q
M
V
Q
R
---
P
L
H
F
A
V
I
D
E
V
D
S
I
L
I
D
E
A
R
T
P
L
I
I
S
G
Q
A
A
-
K
S
T
K
L
Y
V
Q
A
N
A
F
V
R
------------
T
L
---
K
------------
A
-
E
K
D
---------
Y
T
Y
D
I
K
T
K
A
V
Q
L
T
E
E
G
M
T
K
A
E
K
A
F
-------
G
I
-------
D
N
L
F
D
V
K
H
V
A
L
N
H
H
I
N
Q
A
L
K
A
H
V
A
M
Q
K
D
V
D
Y
V
V
E
D
G
Q
-
V
V
I
V
D
S
F
T
G
R
L
M
K
G
R
R
Y
S
E
G
L
H
Q
A
I
E
A
K
E
G
L
E
I
Q
N
E
S
M
T
L
A
T
I
T
F
Q
N
Y
F
R
M
Y
E
K
L
A
G
M
T
G
T
A
K
T
E
E
E
E
F
R
N
I
Y
N
M
Q
V
V
T
I
P
T
N
R
P
V
V
R
D
D
R
P
D
L
I
Y
R
T
M
E
G
K
F
K
A
V
A
E
D
V
A
Q
R
Y
M
T
G
Q
P
V
L
V
G
T
V
A
V
E
T
S
E
L
I
S
K
L
L
----------------------------------------------------------------------------
K
N
K
G
I
P
H
Q
V
L
N
A
K
N
H
E
R
E
A
Q
I
I
E
E
A
G
Q
K
G
A
V
T
I
A
T
N
M
A
G
R
G
T
D
I
K
L
G
------------------------------------------------------------------
E
--------------------------------------------
G
-----------------------------
V
K
E
L
G
G
L
A
V
V
G
T
E
R
H
E
S
R
R
I
D
N
Q
L
R
G
R
S
G
R
Q
G
D
P
G
I
T
Q
F
Y
L
S
M
E
D
E
L
M
R
R
F
G
A
E
R
T
M
A
M
L
D
R
F
G
M
D
D
S
T
P
-
I
Q
S
K
M
V
S
R
A
V
E
S
S
Q
K
R
V
E
G
N
N
F
D
S
R
K
Q
L
L
Q
Y
D
D
V
L
R
Q
Q
R
E
V
I
Y
K
Q
R
F
E
V
I
D
-
S
E
-
N
L
R
E
I
V
E
N
M
I
K
S
S
L
E
R
A
I
A
A
Y
T
---
P
--
R
---
E
E
L
P
E
EWK
L
D
G
L
V
D
L
I
N
-----
T
T
Y
-
L
----
D
E
G
A
L
E
K
S
D
I
F
G
K
E
P
D
E
M
L
E
L
I
M
D
R
I
I
T
K
Y
N
E
K
E
E
Q
F
-----
G
K
E
Q
M
R
E
F
E
K
V
I
V
L
R
A
V
D
S
K
W
M
D
H
I
D
A
M
D
Q
L
R
Q
--------------
G
I
H
L
R
A
Y
----------------------------
A
Q
T
N
P
L
R
E
Y
Q
M
E
G
F
A
M
F
E
H
M
I
E
S
I
E
D
E
V
A
K
F
V
M
K
A
E
I
------
E
N
N
L
E
R
E
E
V
V
Q
G
Q
T
T
A
H
Q
P
Q
E
G
------------------------------------
4
PsiBlast_PDB
78.50
57%
9
- C4 -
-
1M6N
-
SECA_BACSU
A:
[1-780]
M
L
G
I
L
N
K
M
F
D
-
P
T
K
R
T
L
N
R
Y
E
K
-
I
A
N
D
I
D
A
I
R
G
D
Y
E
N
L
S
D
D
A
L
K
H
K
T
I
E
F
K
E
R
L
E
K
---
G
A
T
T
D
D
L
L
V
E
A
F
A
V
V
R
E
A
S
R
R
V
T
G
M
F
P
F
K
V
Q
L
M
G
G
V
A
L
H
D
G
N
I
A
E
M
K
T
G
E
G
K
T
L
T
S
T
L
P
V
Y
L
N
A
L
T
G
K
G
V
H
V
V
T
V
N
E
Y
L
A
S
R
D
A
E
Q
M
G
K
I
F
E
F
L
G
L
T
V
G
L
---------------
N
L
N
S
M
--------------------------------------------------
S
K
D
E
-----------------------------------
K
R
E
A
Y
A
A
D
I
T
Y
S
T
N
N
E
L
G
F
D
Y
L
R
D
N
M
V
L
Y
K
E
Q
M
V
Q
R
---
P
L
H
F
A
V
I
D
E
V
D
S
I
L
I
D
E
A
R
T
P
L
I
I
S
G
-
Q
A
A
K
S
T
K
L
Y
V
Q
A
N
A
F
V
R
------------
T
L
---
K
------------
A
-
E
K
D
---------
Y
T
Y
D
I
K
T
K
A
V
Q
L
T
E
E
G
M
T
K
A
E
K
A
F
-------
G
I
-------
D
N
L
F
D
V
K
H
V
A
L
N
H
H
I
N
Q
A
L
K
A
H
V
A
M
Q
K
D
V
D
Y
V
V
-
E
D
G
Q
V
V
I
V
D
S
F
T
G
R
L
M
K
G
R
R
Y
S
E
G
L
H
Q
A
I
E
A
K
E
G
L
E
I
Q
N
E
S
M
T
L
A
T
I
T
F
Q
N
Y
F
R
M
Y
E
K
L
A
G
M
T
G
T
A
K
T
E
E
E
E
F
R
N
I
Y
N
M
Q
V
V
T
I
P
T
N
R
P
V
V
R
D
D
R
P
D
L
I
Y
R
T
M
E
G
K
F
K
A
V
A
E
D
V
A
Q
R
Y
M
T
G
Q
P
V
L
V
G
T
V
A
V
E
T
S
E
L
I
S
K
L
L
----------------------------------------------------------------------------
K
N
K
G
I
P
H
Q
V
L
N
A
K
N
H
E
R
E
A
Q
I
I
E
E
A
G
Q
K
G
A
V
T
I
A
T
N
M
A
G
R
G
T
D
I
K
L
G
------------------------------------------------------------------
E
--------------------------------------------
G
-----------------------------
V
K
E
L
G
G
L
A
V
V
G
T
E
R
H
E
S
R
R
I
D
N
Q
L
R
G
R
S
G
R
Q
G
D
P
G
I
T
Q
F
Y
L
S
M
E
D
E
L
M
R
R
F
G
A
E
R
T
M
A
M
L
D
R
F
G
M
D
D
-
S
T
P
I
Q
S
K
M
V
S
R
A
V
E
S
S
Q
K
R
V
E
G
N
N
F
D
S
R
K
Q
L
L
Q
Y
D
D
V
L
R
Q
Q
R
E
V
I
Y
K
Q
R
F
E
V
I
D
-
S
E
-
N
L
R
E
I
V
E
N
M
I
K
S
S
L
E
R
A
I
A
A
Y
T
PRE
E
--
L
---
P
E
E
W
K
---
L
D
G
L
V
D
L
I
N
-----
T
T
Y
-
L
----
D
E
G
A
L
E
K
S
D
I
F
G
K
E
P
D
E
M
L
E
L
I
M
D
R
I
I
T
K
Y
N
E
K
E
E
Q
F
-----
G
K
E
Q
M
R
E
F
E
K
V
I
V
L
R
A
V
D
S
K
W
M
D
H
I
D
A
M
D
Q
L
R
Q
--------------
G
I
H
L
R
A
Y
----------------------------
A
Q
T
N
P
L
R
E
Y
Q
M
E
G
F
A
M
F
E
H
M
I
E
S
I
E
D
E
V
A
K
F
V
M
K
A
E
I
----------------------------------------------------------------
5
PsiBlast_PDB
77.63
57%
10
- C4 -
-
1M74
1
SECA_BACSU
A:
[1-780]
M
L
G
I
L
N
K
M
F
D
-
P
T
K
R
T
L
N
R
Y
E
K
-
I
A
N
D
I
D
A
I
R
G
D
Y
E
N
L
S
D
D
A
L
K
H
K
T
I
E
F
K
E
R
L
E
K
---
G
A
T
T
D
D
L
L
V
E
A
F
A
V
V
R
E
A
S
R
R
V
T
G
M
F
P
F
K
V
Q
L
M
G
G
V
A
L
H
D
G
N
I
A
E
M
K
T
G
E
G
K
T
L
T
S
T
L
P
V
Y
L
N
A
L
T
G
K
G
V
H
V
V
T
V
N
E
Y
L
A
S
R
D
A
E
Q
M
G
K
I
F
E
F
L
G
L
T
V
G
L
---------------
N
L
N
S
M
--------------------------------------------------
S
K
D
E
-----------------------------------
K
R
E
A
Y
A
A
D
I
T
Y
S
T
N
N
E
L
G
F
D
Y
L
R
D
N
M
V
L
Y
K
E
Q
M
V
Q
R
---
P
L
H
F
A
V
I
D
E
V
D
S
I
L
I
D
E
A
R
T
P
L
I
I
S
G
-
Q
A
A
K
S
T
K
L
Y
V
Q
A
N
A
F
V
R
------------
T
L
---
K
------------
A
-
E
K
D
---------
Y
T
Y
D
I
K
T
K
A
V
Q
L
T
E
E
G
M
T
K
A
E
K
A
F
-------
G
I
-------
D
N
L
F
D
V
K
H
V
A
L
N
H
H
I
N
Q
A
L
K
A
H
V
A
M
Q
K
D
V
D
Y
V
V
-
E
D
G
Q
V
V
I
V
D
S
F
T
G
R
L
M
K
G
R
R
Y
S
E
G
L
H
Q
A
I
E
A
K
E
G
L
E
I
Q
N
E
S
M
T
L
A
T
I
T
F
Q
N
Y
F
R
M
Y
E
K
L
A
G
M
T
G
T
A
K
T
E
E
E
E
F
R
N
I
Y
N
M
Q
V
V
T
I
P
T
N
R
P
V
V
R
D
D
R
P
D
L
I
Y
R
T
M
E
G
K
F
K
A
V
A
E
D
V
A
Q
R
Y
M
T
G
Q
P
V
L
V
G
T
V
A
V
E
T
S
E
L
I
S
K
L
L
----------------------------------------------------------------------------
K
N
K
G
I
P
H
Q
V
L
N
A
K
N
H
E
R
E
A
Q
I
I
E
E
A
G
Q
K
G
A
V
T
I
A
T
N
M
A
G
R
G
T
D
I
K
L
G
------------------------------------------------------------------
E
--------------------------------------------
G
-----------------------------
V
K
E
L
G
G
L
A
V
V
G
T
E
R
H
E
S
R
R
I
D
N
Q
L
R
G
R
S
G
R
Q
G
D
P
G
I
T
Q
F
Y
L
S
M
E
D
E
L
M
R
R
F
G
A
E
R
T
M
A
M
L
D
R
F
G
M
D
D
-
S
T
P
I
Q
S
K
M
V
S
R
A
V
E
S
S
Q
K
R
V
E
G
N
N
F
D
S
R
K
Q
L
L
Q
Y
D
D
V
L
R
Q
Q
R
E
V
I
Y
K
Q
R
F
E
V
I
D
-
S
E
-
N
L
R
E
I
V
E
N
M
I
K
S
S
L
E
R
A
I
A
A
Y
T
PRE
E
--
L
---
P
E
E
W
K
---
L
D
G
L
V
D
L
I
N
-----
T
T
Y
-
L
----
D
E
G
A
L
E
K
S
D
I
F
G
K
E
P
D
E
M
L
E
L
I
M
D
R
I
I
T
K
Y
N
E
K
E
E
Q
F
-----
G
K
E
Q
M
R
E
F
E
K
V
I
V
L
R
A
V
D
S
K
W
M
D
H
I
D
A
M
D
Q
L
R
Q
--------------
G
I
H
L
R
A
Y
----------------------------
A
Q
T
N
P
L
R
E
Y
Q
M
E
G
F
A
M
F
E
H
M
I
E
S
I
E
D
E
V
A
K
F
V
M
K
A
E
I
----------------------------------------------------------------
3
PsiBlast_PDB
77.47
55%
12
- C4 -
-
3IQY
-
SECA_BACSU
A:
[1-802]
M
L
G
I
L
N
K
M
F
D
-
P
T
K
R
T
L
N
R
Y
E
K
-
I
A
N
D
I
D
A
I
R
G
D
Y
E
N
L
S
D
D
A
L
K
H
K
T
I
E
F
K
E
R
L
E
K
---
G
A
T
T
D
D
L
L
V
E
A
F
A
V
V
R
E
A
S
R
R
V
T
G
M
F
P
F
K
V
Q
L
M
G
G
V
A
L
H
D
G
N
I
A
E
M
K
T
G
E
G
K
T
L
T
S
T
L
P
V
Y
L
N
A
L
T
G
K
G
V
H
V
V
T
V
N
E
Y
L
A
S
R
D
A
E
Q
M
G
K
I
F
E
F
L
G
L
T
V
G
L
---------------
N
L
N
S
M
--------------------------------------------------
S
K
D
E
-----------------------------------
K
R
E
A
Y
A
A
D
I
T
Y
S
T
N
N
E
L
G
F
D
Y
L
R
D
N
M
V
L
Y
K
E
Q
M
V
Q
R
---
P
L
H
F
A
V
I
D
Q
V
D
S
I
L
I
D
E
A
R
T
P
L
I
I
S
G
-
Q
A
A
K
S
T
K
L
Y
V
Q
A
N
A
F
V
R
------------
T
L
---
K
------------
A
-
E
K
D
---------
Y
T
Y
D
I
K
T
K
A
V
Q
L
T
E
E
G
M
T
K
A
E
K
A
F
-------
G
I
-------
D
N
L
F
D
V
K
H
V
A
L
N
H
H
I
N
Q
A
L
K
A
H
V
A
M
Q
K
D
V
D
Y
V
V
-
E
D
G
Q
V
V
I
V
D
S
F
T
G
R
L
M
K
G
R
R
Y
S
E
G
L
H
Q
A
I
E
A
K
E
G
L
E
I
Q
N
E
S
M
T
L
A
T
I
T
F
Q
N
Y
F
R
M
Y
E
K
L
A
G
M
T
G
T
A
K
T
E
E
E
E
F
R
N
I
Y
N
M
Q
V
V
T
I
P
T
N
R
P
V
V
R
D
D
R
P
D
L
I
Y
R
T
M
E
G
K
F
K
A
V
A
E
D
V
A
Q
R
Y
M
T
G
Q
P
V
L
V
G
T
V
A
V
E
T
S
E
L
I
S
K
L
L
----------------------------------------------------------------------------
K
N
K
G
I
P
H
Q
V
L
N
A
K
N
H
E
R
E
A
Q
I
I
E
E
A
G
Q
K
G
A
V
T
I
A
T
N
M
A
G
K
G
T
D
I
K
L
G
------------------------------------------------------------------
E
--------------------------------------------
G
-----------------------------
V
K
E
L
G
G
L
A
V
V
G
T
E
R
H
E
S
R
R
I
D
N
Q
L
R
G
R
S
G
R
Q
G
D
P
G
I
T
Q
F
Y
L
S
M
E
D
E
L
M
R
R
F
G
A
E
R
T
M
A
M
L
D
R
F
G
M
D
D
-
S
T
P
I
Q
S
K
M
V
S
R
A
V
E
S
S
Q
K
R
V
E
G
N
N
F
D
S
R
K
Q
L
L
Q
Y
D
D
V
L
R
Q
Q
R
E
V
I
Y
K
Q
R
F
E
V
I
D
-
S
E
-
N
L
R
E
I
V
E
N
M
I
K
S
S
L
E
R
A
I
A
A
Y
T
PRE
E
--
L
---
P
E
E
W
K
---
L
D
G
L
V
D
L
I
N
-----
T
T
Y
-
L
----
D
E
G
A
L
E
K
S
D
I
F
G
K
E
P
D
E
M
L
E
L
I
M
D
R
I
I
T
K
Y
N
E
K
E
E
Q
F
-----
G
K
E
Q
M
R
E
F
E
K
V
I
V
L
R
A
V
D
S
K
W
M
D
H
I
D
A
M
D
Q
L
R
Q
--------------
G
I
H
L
R
A
Y
----------------------------
A
Q
T
N
P
L
R
E
Y
Q
M
E
G
F
A
M
F
E
H
M
I
E
S
I
E
D
E
V
A
K
F
V
M
K
A
E
I
E
N
N
L
E
R
E
E
V
V
Q
G
Q
T
T
A
H
Q
P
Q
E
G
------------------------------------------
8
PsiBlast_PDB
77.43
57%
13
- C4 -
-
3JV2
1
SECA_BACSU
A:
[18-782]
---------------
T
L
N
R
Y
E
K
-
I
A
N
D
I
D
A
I
R
G
D
Y
E
N
L
S
D
D
A
L
K
H
K
T
I
E
F
K
E
R
L
E
K
---
G
A
T
T
D
D
L
L
V
E
A
F
A
V
V
R
E
A
S
R
R
V
T
G
M
F
P
F
K
V
Q
L
M
G
G
V
A
L
H
D
G
N
I
A
E
M
K
T
G
E
G
K
T
L
T
S
T
L
P
V
Y
L
N
A
L
T
G
K
G
V
H
V
V
T
V
N
E
Y
L
A
S
R
D
A
E
Q
M
G
K
I
F
E
F
L
G
L
T
V
G
L
---------------
N
L
N
S
M
--------------------------------------------------
S
K
D
E
-----------------------------------
K
R
E
A
Y
A
A
D
I
T
Y
S
T
N
N
E
L
G
F
D
Y
L
R
D
N
M
V
L
Y
K
E
Q
M
V
Q
R
---
P
L
H
F
A
V
I
D
E
V
D
S
I
L
I
D
E
A
R
T
P
L
I
I
S
G
-
Q
A
A
K
S
T
K
L
Y
V
Q
A
N
A
F
V
R
------------
T
L
---
K
------------
A
-
E
K
D
---------
Y
T
Y
D
I
K
T
K
A
V
Q
L
T
E
E
G
M
T
K
A
E
K
A
F
-------
G
I
-------
D
N
L
F
D
V
K
H
V
A
L
N
H
H
I
N
Q
A
L
K
A
H
V
A
M
Q
K
D
V
D
Y
V
V
-
E
D
G
Q
V
V
I
V
D
S
F
T
G
R
L
M
K
G
R
R
Y
S
E
G
L
H
Q
A
I
E
A
K
E
G
L
E
I
Q
N
E
S
M
T
L
A
T
I
T
F
Q
N
Y
F
R
M
Y
E
K
L
A
G
M
T
G
T
A
K
T
E
E
E
E
F
R
N
I
Y
N
M
Q
V
V
T
I
P
T
N
R
P
V
V
R
D
D
R
P
D
L
I
Y
R
T
M
E
G
K
F
K
A
V
A
E
D
V
A
Q
R
Y
M
T
G
Q
P
V
L
V
G
T
V
A
V
E
T
S
E
L
I
S
K
L
L
----------------------------------------------------------------------------
K
N
K
G
I
P
H
Q
V
L
N
A
K
N
H
E
R
E
A
Q
I
I
E
E
A
G
Q
K
G
A
V
T
I
A
T
N
M
A
G
R
G
T
D
I
K
L
G
------------------------------------------------------------------
E
--------------------------------------------
G
-----------------------------
V
K
E
L
G
G
L
A
V
V
G
T
E
R
H
E
S
R
R
I
D
N
Q
L
R
G
R
S
G
R
Q
G
D
P
G
I
T
Q
F
Y
L
S
M
E
D
E
L
M
R
R
F
G
A
E
R
T
M
A
M
L
D
R
F
G
M
D
D
-
S
T
P
I
Q
S
K
M
V
S
R
A
V
E
S
S
Q
K
R
V
E
G
N
N
F
D
S
R
K
Q
L
L
Q
Y
D
D
V
L
R
Q
Q
R
E
V
I
Y
K
Q
R
F
E
V
I
D
-
S
E
-
N
L
R
E
I
V
E
N
M
I
K
S
S
L
E
R
A
I
A
A
Y
T
P------------
W
K
---
L
D
G
L
V
D
L
I
N
-----
T
T
Y
-
L
----
D
E
G
A
L
E
K
S
D
I
F
G
K
E
P
D
E
M
L
E
L
I
M
D
R
I
I
T
K
Y
N
E
K
E
E
Q
F
-----
G
K
E
Q
M
R
E
F
E
K
V
I
V
L
R
A
V
D
S
K
W
M
D
H
I
D
A
M
D
Q
L
R
Q
--------------
G
I
H
L
R
A
Y
----------------------------
A
Q
T
N
P
L
R
E
Y
Q
M
E
G
F
A
M
F
E
H
M
I
E
S
I
E
D
E
V
A
K
F
V
M
K
A
E
-----------------------------------------------------------------
45
HHSearch
77.33
57%
9
- C4 -
-
1M6N
-
SECA_BACSU
A:
[2-789]
-
L
G
I
L
N
K
M
F
D
-
P
T
K
R
T
L
N
R
Y
E
K
-
I
A
N
D
I
D
A
I
R
G
D
Y
E
N
L
S
D
D
A
L
K
H
K
T
I
E
F
K
E
R
L
E
K
---
G
A
T
T
D
D
L
L
V
E
A
F
A
V
V
R
E
A
S
R
R
V
T
G
M
F
P
F
K
V
Q
L
M
G
G
V
A
L
H
D
G
N
I
A
E
M
K
T
G
E
G
K
T
L
T
S
T
L
P
V
Y
L
N
A
L
T
G
K
G
V
H
V
V
T
V
N
E
Y
L
A
S
R
D
A
E
Q
M
G
K
I
F
E
F
L
G
L
T
V
G
L
---------------
N
L
N
S
M
--------------------------------------------------
S
K
D
E
-----------------------------------
K
R
E
A
Y
A
A
D
I
T
Y
S
T
N
N
E
L
G
F
D
Y
L
R
D
N
M
V
L
Y
K
E
Q
M
V
Q
R
---
P
L
H
F
A
V
I
D
E
V
D
S
I
L
I
D
E
A
R
T
P
L
I
I
S
G
Q
A
A
K
S
-
T
K
L
Y
V
Q
A
N
A
F
V
R
------------
T
L
---
K
------------
A
E
K
-
D
---------
Y
T
Y
D
I
K
T
K
A
V
Q
L
T
E
E
G
M
T
K
A
E
K
A
F
-------
G
I
-------
D
N
L
F
D
V
K
H
V
A
L
N
H
H
I
N
Q
A
L
K
A
H
V
A
M
Q
K
D
V
D
Y
V
V
E
D
-
G
Q
V
V
I
V
D
S
F
T
G
R
L
M
K
G
R
R
Y
S
E
G
L
H
Q
A
I
E
A
K
E
G
L
E
I
Q
N
E
S
M
T
L
A
T
I
T
F
Q
N
Y
F
R
M
Y
E
K
L
A
G
M
T
G
T
A
K
T
E
E
E
E
F
R
N
I
Y
N
M
Q
V
V
T
I
P
T
N
R
P
V
V
R
D
D
R
P
D
L
I
Y
R
T
M
E
G
K
F
K
A
V
A
E
D
V
A
Q
R
Y
M
T
G
Q
P
V
L
V
G
T
V
A
V
E
T
S
E
L
I
S
K
L
L
----------------------------------------------------------------------------
K
N
K
G
I
P
H
Q
V
L
N
A
K
N
H
E
R
E
A
Q
I
I
E
E
A
G
Q
K
G
A
V
T
I
A
T
N
M
A
G
R
G
T
D
I
K
L
G
------------------------------------------------------------------
E
--------------------------------------------
G
-----------------------------
V
K
E
L
G
G
L
A
V
V
G
T
E
R
H
E
S
R
R
I
D
N
Q
L
R
G
R
S
G
R
Q
G
D
P
G
I
T
Q
F
Y
L
S
M
E
D
E
L
M
R
R
F
G
A
E
R
T
M
A
M
L
D
R
F
G
M
D
D
S
T
P
-
I
Q
S
K
M
V
S
R
A
V
E
S
S
Q
K
R
V
E
G
N
N
F
D
S
R
K
Q
L
L
Q
Y
D
D
V
L
R
Q
Q
R
E
V
I
Y
K
Q
R
F
E
V
I
D
-
S
E
-
N
L
R
E
I
V
E
N
M
I
K
S
S
L
E
R
A
I
A
A
Y
T
---
P
--
R
EEL
P
E
E
W
K
---
L
D
G
L
V
D
L
I
N
T
T
---
Y
L
D
E
G
----
A
L
---
E
K
S
D
I
F
G
K
E
P
D
E
M
L
E
L
I
M
D
R
I
I
T
K
Y
N
E
K
E
E
Q
F
----
G
-
K
E
Q
M
R
E
F
E
K
V
I
V
L
R
A
V
D
S
K
W
M
D
H
I
D
A
M
D
Q
L
R
Q
--------------
G
I
H
L
R
A
Y
----------------------------
A
Q
T
N
P
L
R
E
Y
Q
M
E
G
F
A
M
F
E
H
M
I
E
S
I
E
D
E
V
A
K
F
V
M
K
A
E
I
------
E
N
N
L
E
R
E
E
V
-------------------------------------------------
6
PsiBlast_PDB
76.63
57%
11
- C4 -
-
3IQM
-
SECA_BACSU
A:
[1-780]
M
L
G
I
L
N
K
M
F
D
-
P
T
K
R
T
L
N
R
Y
E
K
-
I
A
N
D
I
D
A
I
R
G
D
Y
E
N
L
S
D
D
A
L
K
H
K
T
I
E
F
K
E
R
L
E
K
---
G
A
T
T
D
D
L
L
V
E
A
F
A
V
V
R
E
A
S
R
R
V
T
G
M
F
P
F
K
V
Q
L
M
G
G
V
A
L
H
D
G
N
I
A
E
M
K
T
G
E
G
K
T
L
T
S
T
L
P
V
Y
L
N
A
L
T
G
K
G
V
H
V
V
T
V
N
E
Y
L
A
S
R
D
A
E
Q
M
G
K
I
F
E
F
L
G
L
T
V
G
L
---------------
N
L
N
S
M
--------------------------------------------------
S
K
D
E
-----------------------------------
K
R
E
A
Y
A
A
D
I
T
Y
S
T
N
N
E
L
G
F
D
Y
L
R
D
N
M
V
L
Y
K
E
Q
M
V
Q
R
---
P
L
H
F
A
V
I
D
Q
V
D
S
I
L
I
D
E
A
R
T
P
L
I
I
S
G
-
Q
A
A
K
S
T
K
L
Y
V
Q
A
N
A
F
V
R
------------
T
L
---
K
------------
A
-
E
K
D
---------
Y
T
Y
D
I
K
T
K
A
V
Q
L
T
E
E
G
M
T
K
A
E
K
A
F
-------
G
I
-------
D
N
L
F
D
V
K
H
V
A
L
N
H
H
I
N
Q
A
L
K
A
H
V
A
M
Q
K
D
V
D
Y
V
V
-
E
D
G
Q
V
V
I
V
D
S
F
T
G
R
L
M
K
G
R
R
Y
S
E
G
L
H
Q
A
I
E
A
K
E
G
L
E
I
Q
N
E
S
M
T
L
A
T
I
T
F
Q
N
Y
F
R
M
Y
E
K
L
A
G
M
T
G
T
A
K
T
E
E
E
E
F
R
N
I
Y
N
M
Q
V
V
T
I
P
T
N
R
P
V
V
R
D
D
R
P
D
L
I
Y
R
T
M
E
G
K
F
K
A
V
A
E
D
V
A
Q
R
Y
M
T
G
Q
P
V
L
V
G
T
V
A
V
E
T
S
E
L
I
S
K
L
L
----------------------------------------------------------------------------
K
N
K
G
I
P
H
Q
V
L
N
A
K
N
H
E
R
E
A
Q
I
I
E
E
A
G
Q
K
G
A
V
T
I
A
T
N
M
A
G
R
G
T
D
I
K
L
G
------------------------------------------------------------------
E
--------------------------------------------
G
-----------------------------
V
K
E
L
G
G
L
A
V
V
G
T
E
R
H
E
S
R
R
I
D
N
Q
L
R
G
R
S
G
R
Q
G
D
P
G
I
T
Q
F
Y
L
S
M
E
D
E
L
M
R
R
F
G
A
E
R
T
M
A
M
L
D
R
F
G
M
D
D
-
S
T
P
I
Q
S
K
M
V
S
R
A
V
E
S
S
Q
K
R
V
E
G
N
N
F
D
S
R
K
Q
L
L
Q
Y
D
D
V
L
R
Q
Q
R
E
V
I
Y
K
Q
R
F
E
V
I
D
-
S
E
-
N
L
R
E
I
V
E
N
M
I
K
S
S
L
E
R
A
I
A
A
Y
T
PRE
E
--
L
---
P
E
E
W
K
---
L
D
G
L
V
D
L
I
N
-----
T
T
Y
-
L
----
D
E
G
A
L
E
K
S
D
I
F
G
K
E
P
D
E
M
L
E
L
I
M
D
R
I
I
T
K
Y
N
E
K
E
E
Q
F
-----
G
K
E
Q
M
R
E
F
E
K
V
I
V
L
R
A
V
D
S
K
W
M
D
H
I
D
A
M
D
Q
L
R
Q
--------------
G
I
H
L
R
A
Y
----------------------------
A
Q
T
N
P
L
R
E
Y
Q
M
E
G
F
A
M
F
E
H
M
I
E
S
I
E
D
E
V
A
K
F
V
M
K
A
E
I
----------------------------------------------------------------
15
PsiBlast_PDB
75.31
44%
-26
- C4 -
-
2FSI
1
SECA_ECOLI
A:
[6-828]
-----------
N
D
R
T
-
L
R
R
M
R
K
-
V
V
N
I
I
N
A
M
E
P
E
M
E
K
L
S
D
E
E
L
K
G
K
T
A
E
F
R
A
R
L
E
K
---
G
E
V
L
E
N
L
I
P
E
A
F
A
V
V
R
E
A
S
K
R
V
F
G
M
R
H
F
D
V
Q
L
L
G
G
M
V
L
N
E
R
C
I
A
E
M
R
T
G
E
G
K
T
L
T
A
T
L
P
A
Y
L
N
A
L
T
G
K
G
V
H
V
V
T
V
N
D
Y
L
A
Q
R
D
A
E
N
N
R
P
L
F
E
F
L
G
L
T
V
G
I
---------------
N
L
P
G
M
--------------------------------------------------
P
A
P
A
-----------------------------------
K
R
E
A
Y
A
A
D
I
T
Y
G
T
N
N
E
Y
G
F
D
Y
L
R
D
N
M
A
F
S
P
E
E
R
V
Q
R
---
K
L
H
Y
A
L
V
D
E
V
D
S
I
L
I
D
E
A
R
T
P
L
I
I
S
G
P
-
A
E
D
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
N
E
N
Q
T
L
A
S
I
T
F
Q
N
Y
F
R
L
Y
E
K
L
A
G
M
T
G
T
A
D
T
E
A
F
E
F
S
S
I
Y
K
L
D
T
V
V
V
P
T
N
R
P
M
I
R
K
D
L
P
D
L
V
Y
M
T
E
A
E
K
I
Q
A
I
I
E
D
I
K
E
R
T
A
K
G
Q
P
V
L
V
G
T
I
S
I
E
K
S
E
L
V
S
N
E
L
----------------------------------------------------------------------------
T
K
A
G
I
K
H
N
V
L
N
A
K
F
H
A
N
E
A
A
I
V
A
Q
A
G
Y
P
A
A
V
T
I
A
T
N
M
A
G
R
G
T
D
I
V
L
G
GS
W
Q
A
E
V
A
A
LENPT
A
E
Q
I
E
K
I
K
A
D
W
Q
V
R
H
-------------------------------------
D
--------------------------------------------
A
-----------------------------
V
L
E
A
G
G
L
H
I
I
G
T
E
R
H
E
S
R
R
I
D
N
Q
L
R
G
R
S
G
R
Q
G
D
A
G
S
S
R
F
Y
L
S
M
E
D
A
L
M
R
I
F
A
S
D
R
V
S
G
M
M
R
K
L
G
M
K
P
G
E
A
-
I
E
H
P
W
V
T
K
A
I
A
N
A
Q
R
K
V
E
S
R
N
F
D
I
R
K
Q
L
L
E
Y
D
D
V
A
N
D
Q
R
R
A
I
Y
S
Q
R
N
E
L
L
D
-
V
S
-
D
V
S
E
T
I
N
S
I
R
E
D
V
F
K
A
T
I
D
A
Y
I
---
P
--
P
---
Q
S
L
E
E
---
M
W
D
I
P
G
L
Q
E
R
L
K
N
D
F
D
L
-
D
----
L
P
I
A
E
W
L
D
K
E
P
E
L
H
E
E
T
L
R
E
R
I
L
A
Q
S
I
E
V
Y
Q
R
K
-
E
E
V
----
V
G
A
E
M
M
R
H
F
E
K
G
V
M
L
Q
T
L
D
S
L
W
K
E
H
L
A
A
M
D
Y
L
R
Q
--------------
G
I
H
L
R
G
Y
----------------------------
A
Q
K
D
P
K
Q
E
Y
K
R
E
S
F
S
M
F
A
A
M
L
E
S
L
K
Y
E
V
I
S
T
L
S
K
V
Q
V
RMPEE-----------------------------------------------------------
41
HHSearch
75.24
47%
20
- C4 -
-
4YS0
1
SECA_THEMA
A:
[6-819]
-----------
K
N
K
R
I
L
K
K
Y
A
K
-
M
V
S
K
I
N
Q
I
E
S
D
L
R
S
K
K
N
S
E
L
I
R
L
S
M
V
L
K
E
K
V
N
S
---
F
E
D
A
D
E
H
L
F
E
A
F
A
L
V
R
E
A
A
R
R
T
L
G
M
R
P
F
D
V
Q
V
M
G
G
I
A
L
H
E
G
K
V
A
E
M
K
T
G
E
G
K
T
L
A
A
T
M
P
I
Y
L
N
A
L
I
G
K
G
V
H
L
V
T
V
N
D
Y
L
A
R
R
D
A
L
W
M
G
P
V
Y
L
F
L
G
L
R
V
G
V
---------------
I
N
S
L
G
K
S
Y
E
V
V
W
KN
P
D
L
A
R
K
A
I
E
E
NWSVWPDGFNGEVLKEESMN
K
E
A
V
E
A
F
Q
V
E
L
K
E
I
T
-----------------------------------
R
K
E
A
Y
L
C
D
V
T
Y
G
T
N
N
E
F
G
F
D
Y
L
R
D
N
L
V
L
D
Y
N
D
K
V
Q
R
---
G
H
F
Y
A
I
V
D
E
A
D
S
V
L
I
D
E
A
R
T
P
L
I
I
S
G
P
S
K
E
S
-
P
S
V
Y
R
R
F
A
Q
I
A
K
------------
K
F
---
V
------------
K
D
K
-
D
---------
F
T
V
D
E
K
A
R
T
I
I
L
T
E
E
G
V
A
K
A
E
K
I
I
-------
G
V
-------
E
N
L
Y
D
P
G
N
V
S
L
L
Y
H
L
I
N
A
L
K
A
L
H
L
F
K
K
D
V
D
Y
V
V
M
N
-
G
E
V
I
I
V
D
E
F
T
G
R
L
L
P
G
R
R
Y
S
G
G
L
H
Q
A
I
E
A
K
E
G
V
P
I
K
E
E
S
I
T
Y
A
T
I
T
F
Q
N
Y
F
R
M
Y
E
K
L
A
G
M
T
G
T
A
K
T
E
E
S
E
F
V
Q
V
Y
G
M
E
V
V
V
I
P
T
H
K
P
M
I
R
K
D
H
D
D
L
V
F
R
T
Q
K
E
K
Y
E
K
I
V
E
E
I
E
K
R
Y
K
K
G
Q
P
V
L
V
G
T
T
S
I
E
K
S
E
L
L
S
S
M
L
----------------------------------------------------------------------------
K
K
K
G
I
P
H
Q
V
L
N
A
K
Y
H
E
K
E
A
E
I
V
A
K
A
G
Q
K
G
M
V
T
I
A
T
N
M
A
G
R
G
T
D
I
K
L
G
------------------------------------------------------------------
P
--------------------------------------------
G
-----------------------------
V
A
E
L
G
G
L
C
I
I
G
T
E
R
H
E
S
R
R
I
D
N
Q
L
R
G
R
A
G
R
Q
G
D
P
G
E
S
I
F
F
L
S
L
E
D
D
L
L
R
I
F
G
S
E
Q
I
G
K
V
M
N
I
L
K
I
E
E
G
Q
P
-
I
Q
H
P
M
L
S
K
L
I
E
N
I
Q
K
K
V
E
G
I
N
F
S
I
R
K
T
L
M
E
M
D
D
V
L
D
K
Q
R
R
A
V
Y
S
L
R
D
Q
I
L
L
-
E
K
-
D
Y
D
E
Y
L
K
D
I
F
E
D
V
V
S
T
R
V
E
E
F
C
---
S
------
G
K
N
W
D
---
I
E
S
L
K
N
S
L
S
F----
F
P
A
G
L
F---
D
L
D
---
E
--
K
Q
F
S
S
S
E
E
L
H
D
Y
L
F
N
R
L
W
E
E
Y
Q
R
K
K
Q
E
I
----
G
--
E
D
Y
R
K
V
I
R
F
L
M
L
R
I
I
D
D
H
W
R
R
Y
L
E
E
V
E
H
V
K
E
--------------
A
V
Q
L
R
S
--------------------------------
D
P
I
V
E
F
K
K
E
T
Y
Y
M
F
D
E
M
M
R
R
I
N
D
T
I
A
N
Y
V
L
R
V
L
E
------
H
---------------------------------------------------------
13
PsiBlast_PDB
74.71
44%
-24
- C4 -
-
2FSF
-
SECA_ECOLI
A:
[14-834]
-----------
N
D
R
T
-
L
R
R
M
R
K
-
V
V
N
I
I
N
A
M
E
P
E
M
E
K
L
S
D
E
E
L
K
G
K
T
A
E
F
R
A
R
L
E
K
---
G
E
V
L
E
N
L
I
P
E
A
F
A
V
V
R
E
A
S
K
R
V
F
G
M
R
H
F
D
V
Q
L
L
G
G
M
V
L
N
E
R
C
I
A
E
M
R
T
G
E
G
K
T
L
T
A
T
L
P
A
Y
L
N
A
L
T
G
K
G
V
H
V
V
T
V
N
D
Y
L
A
Q
R
D
A
E
N
N
R
P
L
F
E
F
L
G
L
T
V
G
I
---------------
N
L
P
G
M
--------------------------------------------------
P
A
P
A
-----------------------------------
K
R
E
A
Y
A
A
D
I
T
Y
G
T
N
N
E
Y
G
F
D
Y
L
R
D
N
M
A
F
S
P
E
E
R
V
Q
R
---
K
L
H
Y
A
L
V
D
E
V
D
S
I
L
I
D
E
A
R
T
P
L
I
I
S
G
P
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
Q
N
E
N
Q
T
L
A
S
I
T
F
Q
N
Y
F
R
L
Y
E
K
L
A
G
M
T
G
T
A
D
T
E
A
F
E
F
S
S
I
Y
K
L
D
T
V
V
V
P
T
N
R
P
M
I
R
K
D
L
P
D
L
V
Y
M
T
E
A
E
K
I
Q
A
I
I
E
D
I
K
E
R
T
A
K
G
Q
P
V
L
V
G
T
I
S
I
E
K
S
E
L
V
S
N
E
L
----------------------------------------------------------------------------
T
K
A
G
I
K
H
N
V
L
N
A
K
F
H
A
N
E
A
A
I
V
A
Q
A
G
Y
P
A
A
V
T
I
A
T
N
M
A
G
R
G
T
D
I
V
L
G
GS
W
Q
A
E
V
A
A
LENPT
A
E
Q
I
E
K
I
K
A
D
W
Q
V
R
H
-------------------------------------
D
--------------------------------------------
A
-----------------------------
V
L
E
A
G
G
L
H
I
I
G
T
E
R
H
E
S
R
R
I
D
N
Q
L
R
G
R
S
G
R
Q
G
D
A
G
S
S
R
F
Y
L
S
M
E
D
A
L
M
R
I
F
A
S
D
R
V
S
G
M
M
R
K
L
G
M
K
P
G
E
A
-
I
E
H
P
W
V
T
K
A
I
A
N
A
Q
R
K
V
E
S
R
N
F
D
I
R
K
Q
L
L
E
Y
D
D
V
A
N
D
Q
R
R
A
I
Y
S
Q
R
N
E
L
L
D
-
V
S
-
D
V
S
E
T
I
N
S
I
R
E
D
V
F
K
A
T
I
D
A
Y
I
---
P
--
P
---
Q
S
L
E
E
---
M
W
D
I
P
G
L
Q
E
R
L
K
N
D
F
D
L
-
D
----
L
P
I
A
E
W
L
D
K
E
P
E
L
H
E
E
T
L
R
E
R
I
L
A
Q
S
I
E
V
Y
Q
R
K
-
E
E
V
----
V
G
A
E
M
M
R
H
F
E
K
G
V
M
L
Q
T
L
D
S
L
W
K
E
H
L
A
A
M
D
Y
L
R
Q
--------------
G
I
H
L
R
G
Y
----------------------------
A
Q
K
D
P
K
Q
E
Y
K
R
E
S
F
S
M
F
A
A
M
L
E
S
L
K
Y
E
V
I
S
T
L
S
K
V
Q
V
RMP-------------------------------------------------------------
14
PsiBlast_PDB
74.67
44%
-24
- C4 -
-
2FSH
1
SECA_ECOLI
A:
[6-828]
-----------
N
D
R
T
-
L
R
R
M
R
K
-
V
V
N
I
I
N
A
M
E
P
E
M
E
K
L
S
D
E
E
L
K
G
K
T
A
E
F
R
A
R
L
E
K
---
G
E
V
L
E
N
L
I
P
E
A
F
A
V
V
R
E
A
S
K
R
V
F
G
M
R
H
F
D
V
Q
L
L
G
G
M
V
L
N
E
R
C
I
A
E
M
R
T
G
E
G
K
T
L
T
A
T
L
P
A
Y
L
N
A
L
T
G
K
G
V
H
V
V
T
V
N
D
Y
L
A
Q
R
D
A
E
N
N
R
P
L
F
E
F
L
G
L
T
V
G
I
---------------
N
L
P
G
M
--------------------------------------------------
P
A
P
A
-----------------------------------
K
R
E
A
Y
A
A
D
I
T
Y
G
T
N
N
E
Y
G
F
D
Y
L
R
D
N
M
A
F
S
P
E
E
R
V
Q
R
---
K
L
H
Y
A
L
V
D
E
V
D
S
I
L
I
D
E
A
R
T
P
L
I
I
S
G
P
-
A
E
D
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
N
E
N
Q
T
L
A
S
I
T
F
Q
N
Y
F
R
L
Y
E
K
L
A
G
M
T
G
T
A
D
T
E
A
F
E
F
S
S
I
Y
K
L
D
T
V
V
V
P
T
N
R
P
M
I
R
K
D
L
P
D
L
V
Y
M
T
E
A
E
K
I
Q
A
I
I
E
D
I
K
E
R
T
A
K
G
Q
P
V
L
V
G
T
I
S
I
E
K
S
E
L
V
S
N
E
L
----------------------------------------------------------------------------
T
K
A
G
I
K
H
N
V
L
N
A
K
F
H
A
N
E
A
A
I
V
A
Q
A
G
Y
P
A
A
V
T
I
A
T
N
M
A
G
R
G
T
D
I
V
L
G
GS
W
Q
A
E
V
A
A
LENPT
A
E
Q
I
E
K
I
K
A
D
W
Q
V
R
H
-------------------------------------
D
--------------------------------------------
A
-----------------------------
V
L
E
A
G
G
L
H
I
I
G
T
E
R
H
E
S
R
R
I
D
N
Q
L
R
G
R
S
G
R
Q
G
D
A
G
S
S
R
F
Y
L
S
M
E
D
A
L
M
R
I
F
A
S
D
R
V
S
G
M
M
R
K
L
G
M
K
P
G
E
A
-
I
E
H
P
W
V
T
K
A
I
A
N
A
Q
R
K
V
E
S
R
N
F
D
I
R
K
Q
L
L
E
Y
D
D
V
A
N
D
Q
R
R
A
I
Y
S
Q
R
N
E
L
L
D
-
V
S
-
D
V
S
E
T
I
N
S
I
R
E
D
V
F
K
A
T
I
D
A
Y
I
---
P
--
P
---
Q
S
L
E
E
---
M
W
D
I
P
G
L
Q
E
R
L
K
N
D
F
D
L
-
D
----
L
P
I
A
E
W
L
D
K
E
P
E
L
H
E
E
T
L
R
E
R
I
L
A
Q
S
I
E
V
Y
Q
R
K
-
E
E
V
----
V
G
A
E
M
M
R
H
F
E
K
G
V
M
L
Q
T
L
D
S
L
W
K
E
H
L
A
A
M
D
Y
L
R
Q
--------------
G
I
H
L
R
G
Y
----------------------------
A
Q
K
D
P
K
Q
E
Y
K
R
E
S
F
S
M
F
A
A
M
L
E
S
L
K
Y
E
V
I
S
T
L
S
K
V
Q
V
R
M
P
E
E-----------------------------------------------------------
36
HHSearch
74.47
49%
39
- C4 -
-
1NKT
1
SECA1_MYCTU
A:
[30-865]
--
D
I
L
S
K
L
L
R
L
G
E
G
R
M
V
K
R
L
K
K
-
V
A
D
Y
V
G
T
L
S
D
D
V
E
K
L
T
D
A
E
L
R
A
K
T
D
E
F
K
R
R
L
A
D
QK
N
P
E
T
L
D
D
L
L
P
E
A
F
A
V
A
R
E
A
A
W
R
V
L
D
Q
R
P
F
D
V
Q
V
M
G
A
A
A
L
H
L
G
N
V
A
E
M
K
T
G
E
G
K
T
L
T
C
V
L
P
A
Y
L
N
A
L
A
G
N
G
V
H
I
V
T
V
N
D
Y
L
A
K
R
D
S
E
W
M
G
R
V
H
R
F
L
G
L
Q
V
G
V
---------------
I
L
A
T
M
--------------------------------------------------
T
P
D
E
-----------------------------------
R
R
V
A
Y
N
A
D
I
T
Y
G
T
N
N
E
F
G
F
D
Y
L
R
D
N
M
A
H
S
L
D
D
L
V
Q
R
---
G
H
H
Y
A
I
V
D
E
V
D
S
I
L
I
D
E
A
R
T
P
L
I
I
S
G
P
A
D
G
A
-
S
N
W
Y
T
E
F
A
R
L
A
P
------------
L
M
---
E
------------
K
D
V
-
H
---------
Y
E
V
D
L
R
K
R
T
V
G
V
H
E
K
G
V
E
F
V
E
D
Q
L
-------
G
I
-------
D
N
L
Y
E
A
A
N
S
P
L
V
S
Y
L
N
N
A
L
K
A
K
E
L
F
S
R
D
K
D
Y
I
V
R
D
-
G
E
V
L
I
V
D
E
F
T
G
R
V
L
I
G
R
R
Y
N
E
G
M
H
Q
A
I
E
A
K
E
H
V
E
I
K
A
E
N
Q
T
L
A
T
I
T
L
Q
N
Y
F
R
L
Y
D
K
L
A
G
M
T
G
T
A
Q
T
E
A
A
E
L
H
E
I
Y
K
L
G
V
V
S
I
P
T
N
M
P
M
I
R
E
D
Q
S
D
L
I
Y
K
T
E
E
A
K
Y
I
A
V
V
D
D
V
A
E
R
Y
A
K
G
Q
P
V
L
I
G
T
T
S
V
E
R
S
E
Y
L
S
R
Q
F
----------------------------------------------------------------------------
T
K
R
R
I
P
H
N
V
L
N
A
K
Y
H
E
Q
E
A
T
I
I
A
V
A
G
R
R
G
G
V
T
V
A
T
N
M
A
G
R
G
T
D
I
V
L
G
------------------------------------------------------------------
G
N
V
D
F
L
T
D
Q
R
L
R
E
R
GLDPVET
P
E
E
Y
E
A
A
W
H
S
E
L
P
I
V
K
E
E
A
S
K
E
A
K
E
-----------------------------
V
I
E
A
G
G
L
Y
V
L
G
T
E
R
H
E
S
R
R
I
D
N
Q
L
R
G
R
S
G
R
Q
G
D
P
G
E
S
R
F
Y
L
S
L
G
D
E
L
M
R
R
F
N
G
A
A
L
E
T
L
L
T
R
L
N
L
P
D
D
V
P
-
I
E
A
K
M
V
T
R
A
I
K
S
A
Q
T
Q
V
E
Q
Q
N
F
E
V
R
K
N
V
L
K
Y
D
E
V
M
N
Q
Q
R
K
V
I
Y
A
E
R
R
R
I
L
E
-
G
E
-
N
L
K
D
Q
A
L
D
M
V
R
D
V
I
T
A
Y
V
D
G
A
T
---
G
EG
Y
---
A
E
D
W
D
---
L
D
A
L
W
T
A
L
K
T
L
---
Y
P
V
G
I
----
T
A
D
S
L
T
-----------
L
L
E
A
L
L
K
D
A
E
R
A
Y
A
A
R
E
A
E
L
E
E
I
A
G
-
E
G
A
M
R
Q
L
E
R
N
V
L
L
N
V
I
D
R
K
W
R
E
H
L
Y
E
M
D
Y
L
K
E
--------------
G
I
G
L
R
A
M
----------------------------
A
Q
R
D
P
L
V
E
Y
Q
R
E
G
Y
D
M
F
M
A
M
L
D
G
M
K
E
E
S
V
G
F
L
F
N
V
T
V
----------------------------------------------------------------
7
PsiBlast_PDB
74.43
57%
7
- C4 -
-
2IBM
1
SECA_BACSU
A:
[1-780]
M
L
G
I
L
N
K
M
F
D
-
P
T
K
R
T
L
N
R
Y
E
K
-
I
A
N
D
I
D
A
I
R
G
D
Y
E
N
L
S
D
D
A
L
K
H
K
T
I
E
F
K
E
R
L
E
K
---
G
A
T
T
D
D
L
L
V
E
A
F
A
V
V
R
E
A
S
R
R
V
T
G
M
F
P
F
K
V
Q
L
M
G
G
V
A
L
H
D
G
N
I
A
E
M
K
T
G
E
G
K
T
L
T
S
T
L
P
V
Y
L
N
A
L
T
G
K
G
V
H
V
V
T
V
N
E
Y
L
A
S
R
D
A
E
Q
M
G
K
I
F
E
F
L
G
L
T
V
G
L
---------------
N
L
N
S
M
--------------------------------------------------
S
K
D
E
-----------------------------------
K
R
E
A
Y
A
A
D
I
T
Y
S
T
N
N
E
L
G
F
D
Y
L
R
D
N
M
V
L
Y
K
E
Q
M
V
Q
R
---
P
L
H
F
A
V
I
D
E
V
D
S
I
L
I
D
E
A
R
T
P
L
I
I
S
G
-
Q
A
A
K
S
T
K
L
Y
V
Q
A
N
A
F
V
R
------------
T
L
---
K
------------
A
-
E
K
D
---------
Y
T
Y
D
I
K
T
K
A
V
Q
L
T
E
E
G
M
T
K
A
E
K
A
F
-------
G
I
-------
D
N
L
F
D
V
K
H
V
A
L
N
H
H
I
N
Q
A
L
K
A
H
V
A
M
Q
K
D
V
D
Y
V
V
-
E
D
G
Q
V
V
I
V
D
S
F
T
G
R
L
M
K
G
R
R
Y
S
E
G
L
H
Q
A
I
E
A
K
E
G
L
E
I
Q
N
E
S
M
T
L
A
T
I
T
F
Q
N
Y
F
R
M
Y
E
K
L
A
G
M
T
G
T
A
K
T
E
E
E
E
F
R
N
I
Y
N
M
Q
V
V
T
I
P
T
N
R
P
V
V
R
D
D
R
P
D
L
I
Y
R
T
M
E
G
K
F
K
A
V
A
E
D
V
A
Q
R
Y
M
T
G
Q
P
V
L
V
G
T
V
A
V
E
T
S
E
L
I
S
K
L
L
----------------------------------------------------------------------------
K
N
K
G
I
P
H
Q
V
L
N
A
K
N
H
E
R
E
A
Q
I
I
E
E
A
G
Q
K
G
A
V
T
I
A
T
N
M
A
G
R
G
T
D
I
K
L
G
------------------------------------------------------------------
E
--------------------------------------------
G
-----------------------------
V
K
E
L
G
G
L
A
V
V
G
T
E
R
H
E
S
R
R
I
D
N
Q
L
R
G
R
S
G
R
Q
G
D
P
G
I
T
Q
F
Y
L
S
M
E
D
E
L
M
R
R
F
G
A
E
R
T
M
A
M
L
D
R
F
G
M
D
D
-
S
T
P
I
Q
S
K
M
V
S
R
A
V
E
S
S
Q
K
R
V
E
G
N
N
F
D
S
R
K
Q
L
L
Q
Y
D
D
V
L
R
Q
Q
R
E
V
I
Y
K
Q
R
F
E
V
I
D
-
S
E
-
N
L
R
E
I
V
E
N
M
I
K
S
S
L
E
R
A
I
A
A
Y
T
P
R
E
E
--
L
---
P
E
E
W
K
---
L
D
G
L
V
D
L
I
N
-----
T
T
Y
-
L
----
D
E
G
A
L
E
K
S
D
I
F
G
K
E
P
D
E
M
L
E
L
I
M
D
R
I
I
T
K
Y
N
E
K
E
E
Q
F
-----
G
K
E
Q
M
R
E
F
E
K
V
I
V
L
R
A
V
D
S
K
W
M
D
H
I
D
A
M
D
Q
L
R
Q
--------------
G
I
H
L
R
A
Y
----------------------------
A
Q
T
N
P
L
R
E
Y
Q
M
E
G
F
A
M
F
E
H
M
I
E
S
I
E
D
E
V
A
K
F
V
M
K
A
E
I
----------------------------------------------------------------
40
HHSearch
74.37
48%
8
- C4 -
-
2VDA
-
SECA_ECOLI
A:
[13-833]
-----------
R
N
D
R
T
L
R
R
M
R
K
-
V
V
N
I
I
N
A
M
E
P
E
M
E
K
L
S
D
E
E
L
K
G
K
T
A
E
F
R
A
R
L
E
K
---
G
E
V
L
E
N
L
I
P
E
A
F
A
V
V
R
E
A
S
K
R
V
F
G
M
R
H
F
D
V
Q
L
L
G
G
M
V
L
N
E
R
C
I
A
E
M
R
T
G
E
G
K
T
L
T
A
T
L
P
A
Y
L
N
A
L
T
G
K
G
V
H
V
V
T
V
N
D
Y
L
A
Q
R
D
A
E
N
N
R
P
L
F
E
F
L
G
L
T
V
G
I
---------------
N
L
P
G
M
--------------------------------------------------
P
A
P
A
-----------------------------------
K
R
E
A
Y
A
A
D
I
T
Y
G
T
N
N
E
Y
G
F
D
Y
L
R
D
N
M
A
F
S
P
E
E
R
V
Q
R
---
K
L
H
Y
A
L
V
D
E
V
D
S
I
L
I
D
E
A
R
T
P
L
I
I
S
G
P
A
E
D
S
-
S
E
M
Y
K
R
V
N
K
I
I
P
------------
H
L
---
I
RQEKEDSETFQG
E
-
G
-
H
---------
F
S
V
D
E
K
S
R
Q
V
N
L
T
E
R
G
L
V
L
I
E
E
L
L
-------
V
K
EGIMDEG
E
S
L
Y
S
P
A
N
I
M
L
M
H
H
V
T
A
A
L
R
A
H
A
L
F
T
R
D
V
D
Y
I
V
K
D
-
G
E
V
I
I
V
D
E
H
T
G
R
T
M
Q
G
R
R
W
S
D
G
L
H
Q
A
V
E
A
K
E
G
V
Q
I
Q
N
E
N
Q
T
L
A
S
I
T
F
Q
N
Y
F
R
L
Y
E
K
L
A
G
M
T
G
T
A
D
T
E
A
F
E
F
S
S
I
Y
K
L
D
T
V
V
V
P
T
N
R
P
M
I
R
K
D
L
P
D
L
V
Y
M
T
E
A
E
K
I
Q
A
I
I
E
D
I
K
E
R
T
A
K
G
Q
P
V
L
V
G
T
I
S
I
E
K
S
E
L
V
S
N
E
L
----------------------------------------------------------------------------
T
K
A
G
I
K
H
N
V
L
N
A
K
F
H
A
N
E
A
A
I
V
A
Q
A
G
Y
P
A
A
V
T
I
A
T
N
M
A
G
R
G
T
D
I
V
L
G
------------------------------------------------------------------
G
S
W
Q
A
E
V
A
A
LENPT
A
E
Q
I
E
K
I
K
A
D
W
Q
V
R
H
D
---------------
A
-----------------------------
V
L
E
A
G
G
L
H
I
I
G
T
E
R
H
E
S
R
R
I
D
N
Q
L
R
G
R
S
G
R
Q
G
D
A
G
S
S
R
F
Y
L
S
M
E
D
A
L
M
R
I
F
A
S
D
R
V
S
G
M
M
R
K
L
G
M
K
P
G
E
A
-
I
E
H
P
W
V
T
K
A
I
A
N
A
Q
R
K
V
E
S
R
N
F
D
I
R
K
Q
L
L
E
Y
D
D
V
A
N
D
Q
R
R
A
I
Y
S
Q
R
N
E
L
L
D
-
V
S
-
D
V
S
E
T
I
N
S
I
R
E
D
V
F
K
A
T
I
D
A
Y
I
---
P
--
P
QSL
E
E
M
W
D
---
I
P
G
L
Q
E
R
L
K
N
D---
F
D
L
D
L
----
P
I
A
E
W
L
D
K
-
E
P
E
L
H
E
E
T
L
R
E
R
I
L
A
Q
S
I
E
V
Y
Q
R
K
E
E
V
V
----
G
-
A
E
M
M
R
H
F
E
K
G
V
M
L
Q
T
L
D
S
L
W
K
E
H
L
A
A
M
D
Y
L
R
Q
--------------
G
I
H
L
R
G
Y
----------------------------
A
Q
K
D
P
K
Q
E
Y
K
R
E
S
F
S
M
F
A
A
M
L
E
S
L
K
Y
E
V
I
S
T
L
S
K
V
Q
V
------
R
M
--------------------------------------------------------
44
HHSearch
74.13
48%
-10
- C4 -
-
2FSF
-
SECA_ECOLI
B:
[13-832]
-----------
R
N
D
R
T
L
R
R
M
R
K
-
V
V
N
I
I
N
A
M
E
P
E
M
E
K
L
S
D
E
E
L
K
G
K
T
A
E
F
R
A
R
L
E
K
---
G
E
V
L
E
N
L
I
P
E
A
F
A
V
V
R
E
A
S
K
R
V
F
G
M
R
H
F
D
V
Q
L
L
G
G
M
V
L
N
E
R
C
I
A
E
M
R
T
G
E
G
K
T
L
T
A
T
L
P
A
Y
L
N
A
L
T
G
K
G
V
H
V
V
T
V
N
D
Y
L
A
Q
R
D
A
E
N
N
R
P
L
F
E
F
L
G
L
T
V
G
I
---------------
N
L
P
G
M
--------------------------------------------------
P
A
P
A
-----------------------------------
K
R
E
A
Y
A
A
D
I
T
Y
G
T
N
N
E
Y
G
F
D
Y
L
R
D
N
M
A
F
S
P
E
E
R
V
Q
R
---
K
L
H
Y
A
L
V
D
E
V
D
S
I
L
I
D
E
A
R
T
P
L
I
I
S
G
P
A
E
D
S
--------------------------------------------------------------------------
V
L
I
E
E
L
L
-------
V
K
EGIMDEG
E
S
L
Y
S
P
A
N
I
M
L
M
H
H
V
T
A
A
----------------------------------------------------
I
Q
N
E
N
Q
T
L
A
S
I
T
F
Q
N
Y
F
R
L
Y
E
K
L
A
G
M
T
G
T
A
D
T
E
A
F
E
F
S
S
I
Y
K
L
D
T
V
V
V
P
T
N
R
P
M
I
R
K
D
L
P
D
L
V
Y
M
T
E
A
E
K
I
Q
A
I
I
E
D
I
K
E
R
T
A
K
G
Q
P
V
L
V
G
T
I
S
I
E
K
S
E
L
V
S
N
E
L
----------------------------------------------------------------------------
T
K
A
G
I
K
H
N
V
L
N
A
K
F
H
A
N
E
A
A
I
V
A
Q
A
G
Y
P
A
A
V
T
I
A
T
N
M
A
G
R
G
T
D
I
V
L
G
------------------------------------------------------------------
G
S
W
Q
A
E
V
A
A
LENPT
A
E
Q
I
E
K
I
K
A
D
W
Q
V
R
H
D
---------------
A
-----------------------------
V
L
E
A
G
G
L
H
I
I
G
T
E
R
H
E
S
R
R
I
D
N
Q
L
R
G
R
S
G
R
Q
G
D
A
G
S
S
R
F
Y
L
S
M
E
D
A
L
M
R
I
F
A
S
D
R
V
S
G
M
M
R
K
L
G
M
K
P
G
E
A
-
I
E
H
P
W
V
T
K
A
I
A
N
A
Q
R
K
V
E
S
R
N
F
D
I
R
K
Q
L
L
E
Y
D
D
V
A
N
D
Q
R
R
A
I
Y
S
Q
R
N
E
L
L
D
-
V
S
-
D
V
S
E
T
I
N
S
I
R
E
D
V
F
K
A
T
I
D
A
Y
I
---
P
--
P
QSL
E
E
M
W
D
---
I
P
G
L
Q
E
R
L
K
N
D
---
F
D
L
D
L
----
P
I
A
E
W
L
D
K
-
E
P
E
L
H
E
E
T
L
R
E
R
I
L
A
Q
S
I
E
V
Y
Q
R
K
E
E
V
V
----
G
-
A
E
M
M
R
H
F
E
K
G
V
M
L
Q
T
L
D
S
L
W
K
E
H
L
A
A
M
D
Y
L
R
Q
--------------
G
I
H
L
R
G
Y
----------------------------
A
Q
K
D
P
K
Q
E
Y
K
R
E
S
F
S
M
F
A
A
M
L
E
S
L
K
Y
E
V
I
S
T
L
S
K
V
Q
V
------
R
---------------------------------------------------------
59
Fugue
73.14
49%
25
- C4 -
-
2IPC
-
SECA_THET8
A:
[1-939]
M
L
G
L
L
R
R
L
F
D
-
N
N
E
R
E
I
A
R
Y
Y
K
Q
V
V
E
P
V
N
R
L
E
A
E
V
E
K
L
P
D
--
L
A
A
A
Y
R
E
L
K
E
K
H
E
K
---
G
A
S
L
D
E
L
L
P
M
A
F
A
L
T
R
E
S
A
K
R
Y
L
G
M
R
H
F
D
V
Q
L
I
G
G
A
V
L
H
E
G
K
I
A
E
M
K
T
G
E
G
K
T
L
V
A
T
L
A
V
A
L
N
A
L
T
G
K
G
V
H
V
V
T
V
N
D
Y
L
A
R
R
D
A
E
W
M
G
P
V
Y
R
G
L
G
L
S
V
G
V
---------------
I
Q
H
A
S
--------------------------------------------------
T
P
A
E
-----------------------------------
R
R
K
A
Y
L
A
D
V
T
Y
V
T
N
S
E
L
G
F
D
Y
L
R
D
N
M
A
I
S
P
D
Q
L
V
L
R
HDH
P
L
H
Y
A
I
I
D
E
V
D
S
I
L
I
D
E
A
R
T
P
L
I
I
S
G
P
A
E
K
A
T
D
L
Y
Y
K
M
A
E
I
A
K
K
L
E
R
G
L
P
A
EPGVR
K
E
---
P
------------
T
-
G
-
D
---------
Y
T
V
E
E
K
N
R
S
V
H
L
T
L
Q
G
I
A
K
A
E
K
L
L
-------
G
I
-------
E
G
L
F
S
P
E
N
M
E
L
A
H
M
L
I
Q
A
I
R
A
K
E
L
Y
H
R
D
R
D
Y
I
V
Q
D
G
Q
-
V
I
I
V
D
E
F
T
G
R
L
M
P
G
R
R
Y
G
E
G
L
H
Q
A
I
E
A
K
E
G
V
R
I
E
R
E
N
Q
T
L
A
T
I
T
Y
Q
N
F
F
R
L
Y
E
K
R
A
G
M
T
G
T
A
K
T
E
E
K
E
F
Q
E
I
Y
G
M
D
V
V
V
V
P
T
N
R
P
V
I
R
K
D
F
P
D
V
V
Y
R
T
E
K
G
K
F
Y
A
V
V
E
E
I
A
E
K
Y
E
R
G
Q
P
V
L
V
G
T
I
S
I
E
K
S
E
R
L
S
Q
M
L
K
E
PRLY
L
P
R
L
E
M
R
L
E
L
F
K
K
A
S
QKQQG
P
E
W
E
R
L
R
KLLERPAQLKDEDLAPFEGLIPPKG
N
L
R
T
A
W
E
G
L
K
R
A
V
H
T
L
A
V
L
R
Q
G
I
P
H
Q
V
L
N
A
K
H
H
A
R
E
A
E
I
V
A
Q
A
G
R
S
K
T
V
T
I
A
T
N
M
A
G
R
G
T
D
I
K
L
G
GN
P
E
Y
L
A
A
A
L
L
E
K
EGFDRYEWK
V
E
L
F
I
K
K
M
V
A
GK
E
E
E
A
R
A
L
A
Q
E
L
GIR
E
E
L
L
E
R
I
R
E
I
R
E
E
C
K
Q
D
E
E
--------------------------------------------
R
-----------------------------
V
R
A
L
G
G
L
F
I
I
G
T
E
R
H
E
S
R
R
I
D
N
Q
L
R
G
R
A
G
R
Q
G
D
P
G
G
S
R
F
Y
V
S
F
D
D
D
L
M
R
L
F
A
S
D
R
V
I
A
M
L
D
R
M
G
F
D
D
S
E
P
-
I
E
H
P
M
V
T
R
S
I
E
R
A
Q
K
R
V
E
D
R
N
F
A
I
R
K
Q
L
L
Q
F
D
D
V
L
S
R
Q
R
E
V
I
Y
A
Q
R
R
L
I
L
L
G
K
D
E
E
V
K
E
A
A
I
G
M
V
E
E
T
V
A
S
L
A
E
N
F
L
---
N
--
P
---
E
V
H
P
E
----
D
W
D
L
E
G
L
K
-----
A
T
L
-
L
D
T
A
P
Q
L
Q
D
F
P
F
A
E
L
R
A
L
K
A
E
E
A
V
E
R
L
V
E
A
A
L
K
A
Y
E
A
R
E
A
E
L
-----
S
P
P
L
M
R
A
V
E
R
F
V
I
L
N
V
V
D
N
A
W
K
E
H
L
H
N
L
D
V
L
R
Q
--------------
G
I
F
L
R
G
Y
----------------------------
G
Q
K
D
P
F
Q
E
Y
K
I
E
A
T
R
L
F
N
E
M
V
A
F
I
K
S
E
V
A
K
F
L
F
R
L
K
V
------
E
---------------------------------------------------------
42
HHSearch
72.96
47%
27
- C4 -
-
3JUX
1
SECA_THEMA
A:
[6-816]
-----------
K
N
K
R
I
L
K
K
Y
A
K
-
M
V
S
K
I
N
Q
I
E
S
D
L
R
S
K
K
N
S
E
L
I
R
L
S
M
V
L
K
E
K
V
N
S
---
F
E
D
A
D
E
H
L
F
E
A
F
A
L
V
R
E
A
A
R
R
T
L
G
M
R
P
F
D
V
Q
V
M
G
G
I
A
L
H
E
G
K
V
A
E
M
K
T
G
E
G
K
T
L
A
A
T
M
P
I
Y
L
N
A
L
I
G
K
G
V
H
L
V
T
V
N
D
Y
L
A
R
R
D
A
L
W
M
G
P
V
Y
L
F
L
G
L
R
V
G
V
---------------
I
N
S
L
G
K
S
Y
E
V
V
WKN
P
D
L
A
R
K
A
I
E
E
NWSVWPDGFNGEVLKEESMN
K
E
A
V
E
A
F
Q
V
E
L
K
E
I
T
-----------------------------------
R
K
E
A
Y
L
C
D
V
T
Y
G
T
N
N
E
F
G
F
D
Y
L
R
D
N
L
V
L
D
Y
N
D
K
V
Q
R
---
G
H
F
Y
A
I
V
D
E
A
D
S
V
L
I
D
E
A
R
T
P
L
I
I
S
G
P
S
K
E
S
-
P
S
V
Y
R
R
F
A
Q
I
A
K
------------
K
F
---
V
------------
K
D
K
-
D
---------
F
T
V
D
E
K
A
R
T
I
I
L
T
E
E
G
V
A
K
A
E
K
I
I
-------
G
V
-------
E
N
L
Y
D
P
G
N
V
S
L
L
Y
H
L
I
N
A
L
K
A
L
H
L
F
K
K
D
V
D
Y
V
V
M
N
-
G
E
V
I
I
V
D
E
F
T
G
R
L
L
P
G
R
R
Y
S
G
G
L
H
Q
A
I
E
A
K
E
G
V
P
I
K
E
E
S
I
T
Y
A
T
I
T
F
Q
N
Y
F
R
M
Y
E
K
L
A
G
M
T
G
T
A
K
T
E
E
S
E
F
V
Q
V
Y
G
M
E
V
V
V
I
P
T
H
K
P
M
I
R
K
D
H
D
D
L
V
F
R
T
Q
K
E
K
Y
E
K
I
V
E
E
I
E
K
R
Y
K
K
G
Q
P
V
L
V
G
T
T
S
I
E
K
S
E
L
L
S
S
M
L
----------------------------------------------------------------------------
K
K
K
G
I
P
H
Q
V
L
N
A
K
Y
H
E
K
E
A
E
I
V
A
K
A
G
Q
K
G
M
V
T
I
A
T
N
M
A
G
R
G
T
D
I
K
L
G
------------------------------------------------------------------
P
--------------------------------------------
G
-----------------------------
V
A
E
L
G
G
L
C
I
I
G
T
E
R
H
E
S
R
R
I
D
N
Q
L
R
G
R
A
G
R
Q
G
D
P
G
E
S
I
F
F
L
S
L
E
D
D
L
L
R
I
F
G
S
E
Q
I
G
K
V
M
N
I
L
K
I
E
E
G
Q
P
-
I
Q
H
P
M
L
S
K
L
I
E
N
I
Q
K
K
V
E
G
I
N
F
S
I
R
K
T
L
M
E
M
D
D
V
L
D
K
Q
R
R
A
V
Y
S
L
R
D
Q
I
L
L
-
E
K
-
D
Y
D
E
Y
L
K
D
I
F
E
D
V
V
S
T
R
V
E
E
F
C
---
S
------
G
K
N
W
D
---
I
E
S
L
K
N
S
L
S
F----
F
P
A
G
L
F---
D
L
D
---
E
--
K
Q
F
S
S
S
E
E
L
H
D
Y
L
F
N
R
L
W
E
E
Y
Q
R
K
K
Q
E
I
----
G
--
E
D
Y
R
K
V
I
R
F
L
M
L
R
I
I
D
D
H
W
R
R
Y
L
E
E
V
E
H
V
K
E
--------------
A
V
Q
L
R
S
Y
----------------------------
G
Q
K
D
P
I
V
E
F
K
K
E
T
Y
Y
M
F
D
E
M
M
R
R
I
N
D
T
I
A
N
Y
V
L
R
V
------------------------------------------------------------------
18
PsiBlast_PDB
72.72
45%
23
- C4 -
-
4YS0
1
SECA_THEMA
A:
[3-805]
-------
L
F
D
-
K
N
K
R
I
L
K
K
Y
A
K
-
M
V
S
K
I
N
Q
I
E
S
D
L
R
S
K
K
N
S
E
L
I
R
L
S
M
V
L
K
E
K
V
N
S
---
F
E
D
A
D
E
H
L
F
E
A
F
A
L
V
R
E
A
A
R
R
T
L
G
M
R
P
F
D
V
Q
V
M
G
G
I
A
L
H
E
G
K
V
A
E
M
K
T
G
E
G
K
T
L
A
A
T
M
P
I
Y
L
N
A
L
I
G
K
G
V
H
L
V
T
V
N
D
Y
L
A
R
R
D
A
L
W
M
G
P
V
Y
L
F
L
G
L
R
V
G
V
I
N
S
LG
K
S
Y
E
V
V
W
KN
P
D
L
A
R
K
--------------------------------------------------
A
I
E
E
NWSVWPDGFNGEVLKEESMN
K
E
A
V
E
A
F
Q
V
E
L
K
E
I
T
R
K
E
A
Y
L
C
D
V
T
Y
G
T
N
N
E
F
G
F
D
Y
L
R
D
N
L
V
L
D
Y
N
D
K
V
Q
R
---
G
H
F
Y
A
I
V
D
E
A
D
S
V
L
I
D
E
A
R
T
P
L
I
I
S
G
P
S
K
-
E
S
P
S
V
Y
R
R
F
A
Q
I
A
K
------------
K
F
---
V
------------
K
-
D
K
D
---------
F
T
V
D
E
K
A
R
T
I
I
L
T
E
E
G
V
A
K
A
E
K
I
I
-------
G
V
-------
E
N
L
Y
D
P
G
N
V
S
L
L
Y
H
L
I
N
A
L
K
A
L
H
L
F
K
K
D
V
D
Y
V
V
M
N
-
G
E
V
I
I
V
D
E
F
T
G
R
L
L
P
G
R
R
Y
S
G
G
L
H
Q
A
I
E
A
K
E
G
V
P
I
K
E
E
S
I
T
Y
A
T
I
T
F
Q
N
Y
F
R
M
Y
E
K
L
A
G
M
T
G
T
A
K
T
E
E
S
E
F
V
Q
V
Y
G
M
E
V
V
V
I
P
T
H
K
P
M
I
R
K
D
H
D
D
L
V
F
R
T
Q
K
E
K
Y
E
K
I
V
E
E
I
E
K
R
Y
K
K
G
Q
P
V
L
V
G
T
T
S
I
E
K
S
E
L
L
S
S
M
L
----------------------------------------------------------------------------
K
K
K
G
I
P
H
Q
V
L
N
A
K
Y
H
E
K
E
A
E
I
V
A
K
A
G
Q
K
G
M
V
T
I
A
T
N
M
A
G
R
G
T
D
I
K
L
G
------------------------------------------------------------------
P
--------------------------------------------
G
-----------------------------
V
A
E
L
G
G
L
C
I
I
G
T
E
R
H
E
S
R
R
I
D
N
Q
L
R
G
R
A
G
R
Q
G
D
P
G
E
S
I
F
F
L
S
L
E
D
D
L
L
R
I
F
G
S
E
Q
I
G
K
V
M
N
I
L
K
I
E
E
G
Q
P
-
I
Q
H
P
M
L
S
K
L
I
E
N
I
Q
K
K
V
E
G
I
N
F
S
I
R
K
T
L
M
E
M
D
D
V
L
D
K
Q
R
R
A
V
Y
S
L
R
-
D
Q
I
L
-
L
E
K
D
Y
D
E
Y
L
K
D
I
F
E
D
V
V
S
T
R
V
E
E
F
C
---
S
--
G
---
K
-
N
W
D
---
I
E
S
L
K
N
--
S
-----
L
S
F
-
F
----
P
A
G
L
F
D
L
D
E
K
Q
F
S
S
S
E
E
L
H
D
Y
L
F
N
R
L
W
E
E
Y
--
Q
R
K
K
Q
----
E
I
G
E
D
Y
R
K
V
I
R
F
L
M
L
R
I
I
D
D
H
W
R
R
Y
L
E
E
V
E
H
V
K
E
--------------
A
V
Q
L
R
S
--------------------------------
D
P
I
V
E
F
K
K
E
T
Y
Y
M
F
D
E
M
M
R
R
I
-----------------------------------------------------------------------------
19
PsiBlast_PDB
71.07
45%
31
- C4 -
-
3JUX
1
SECA_THEMA
A:
[4-805]
--------
F
D
-
K
N
K
R
I
L
K
K
Y
A
K
-
M
V
S
K
I
N
Q
I
E
S
D
L
R
S
K
K
N
S
E
L
I
R
L
S
M
V
L
K
E
K
V
N
S
---
F
E
D
A
D
E
H
L
F
E
A
F
A
L
V
R
E
A
A
R
R
T
L
G
M
R
P
F
D
V
Q
V
M
G
G
I
A
L
H
E
G
K
V
A
E
M
K
T
G
E
G
K
T
L
A
A
T
M
P
I
Y
L
N
A
L
I
G
K
G
V
H
L
V
T
V
N
D
Y
L
A
R
R
D
A
L
W
M
G
P
V
Y
L
F
L
G
L
R
V
G
V
I
N
S
LG
K
S
Y
E
V
V
WKN
P
D
L
A
R
K
--------------------------------------------------
A
I
E
E
NWSVWPDGFNGEVLKEESMN
K
E
A
V
E
A
F
Q
V
E
L
K
E
I
T
R
K
E
A
Y
L
C
D
V
T
Y
G
T
N
N
E
F
G
F
D
Y
L
R
D
N
L
V
L
D
Y
N
D
K
V
Q
R
---
G
H
F
Y
A
I
V
D
E
A
D
S
V
L
I
D
E
A
R
T
P
L
I
I
S
G
P
S
K
-
E
S
P
S
V
Y
R
R
F
A
Q
I
A
K
------------
K
F
---
V
------------
K
-
D
K
D
---------
F
T
V
D
E
K
A
R
T
I
I
L
T
E
E
G
V
A
K
A
E
K
I
I
-------
G
V
-------
E
N
L
Y
D
P
G
N
V
S
L
L
Y
H
L
I
N
A
L
K
A
L
H
L
F
K
K
D
V
D
Y
V
V
M
N
-
G
E
V
I
I
V
D
E
F
T
G
R
L
L
P
G
R
R
Y
S
G
G
L
H
Q
A
I
E
A
K
E
G
V
P
I
K
E
E
S
I
T
Y
A
T
I
T
F
Q
N
Y
F
R
M
Y
E
K
L
A
G
M
T
G
T
A
K
T
E
E
S
E
F
V
Q
V
Y
G
M
E
V
V
V
I
P
T
H
K
P
M
I
R
K
D
H
D
D
L
V
F
R
T
Q
K
E
K
Y
E
K
I
V
E
E
I
E
K
R
Y
K
K
G
Q
P
V
L
V
G
T
T
S
I
E
K
S
E
L
L
S
S
M
L
----------------------------------------------------------------------------
K
K
K
G
I
P
H
Q
V
L
N
A
K
Y
H
E
K
E
A
E
I
V
A
K
A
G
Q
K
G
M
V
T
I
A
T
N
M
A
G
R
G
T
D
I
K
L
G
------------------------------------------------------------------
P
--------------------------------------------
G
-----------------------------
V
A
E
L
G
G
L
C
I
I
G
T
E
R
H
E
S
R
R
I
D
N
Q
L
R
G
R
A
G
R
Q
G
D
P
G
E
S
I
F
F
L
S
L
E
D
D
L
L
R
I
F
G
S
E
Q
I
G
K
V
M
N
I
L
K
I
E
E
G
Q
P
-
I
Q
H
P
M
L
S
K
L
I
E
N
I
Q
K
K
V
E
G
I
N
F
S
I
R
K
T
L
M
E
M
D
D
V
L
D
K
Q
R
R
A
V
Y
S
L
R
-
D
Q
I
L
-
L
E
K
D
Y
D
E
Y
L
K
D
I
F
E
D
V
V
S
T
R
V
E
E
F
C
---
S
--
G
---
K
-
N
W
D
---
I
E
S
L
K
N
--
S
-----
L
S
F
-
F
----
P
A
G
L
F
D
L
D
E
K
Q
F
S
S
S
E
E
L
H
D
Y
L
F
N
R
L
W
E
E
Y
--
Q
R
K
K
Q
----
E
I
G
E
D
Y
R
K
V
I
R
F
L
M
L
R
I
I
D
D
H
W
R
R
Y
L
E
E
V
E
H
V
K
E
--------------
A
V
Q
L
R
S
Y
----------------------------
G
Q
K
D
P
I
V
E
F
K
K
E
T
Y
Y
M
F
D
E
M
M
R
R
I
-----------------------------------------------------------------------------
25
PsiBlast_CBE
66.39
51%
-20
- C4 -
-
5K9T
1
?
A:
[6-578]
----------------
L
R
R
M
R
K
-
V
V
N
I
I
N
A
M
E
P
E
M
E
K
L
S
D
E
E
L
K
G
K
T
A
E
F
R
A
R
L
A
A
---
G
A
V
L
E
N
L
I
P
E
A
F
A
V
V
R
E
A
S
K
R
V
F
G
M
R
H
F
D
V
Q
L
L
G
G
M
V
L
N
E
R
C
I
A
E
M
R
T
G
E
G
K
T
L
T
A
T
L
P
A
Y
L
N
A
L
T
G
K
G
V
H
V
V
T
V
N
D
Y
L
A
Q
R
D
A
E
N
N
R
P
L
F
E
F
L
G
L
T
V
G
I
---------------
N
L
P
G
M
--------------------------------------------------
P
A
P
A
-----------------------------------
K
R
E
A
Y
A
A
D
I
T
Y
G
T
N
N
E
Y
G
F
D
Y
L
R
D
N
M
A
F
S
P
A
A
R
V
Q
R
---
K
L
H
Y
A
L
V
D
E
V
D
S
I
L
I
D
E
A
R
T
P
L
I
I
S
G
P
-
A
E
D
S
S
E
M
Y
K
R
V
N
K
I
I
P
------------
H
L
I
R
Q
E
------------
K
-
E
-
D
SETFQGEGH
F
S
V
D
E
K
S
R
Q
V
N
L
T
E
R
G
L
V
L
I
E
E
L
L
V
K
E
GIMD
E
G
-------
E
S
L
Y
S
P
A
N
I
M
L
M
H
H
V
T
A
A
L
R
A
H
A
L
F
T
R
D
V
D
Y
I
V
-
K
D
G
E
V
I
I
V
D
E
H
T
G
R
T
M
Q
G
R
R
W
S
D
G
L
H
Q
A
V
E
A
K
E
G
V
Q
I
Q
N
E
N
Q
T
L
A
S
I
T
F
Q
N
Y
F
R
L
Y
E
K
L
A
G
M
T
G
T
A
D
T
E
A
F
E
F
S
S
I
Y
K
L
D
T
V
V
V
P
T
N
R
P
M
I
R
K
D
L
P
D
L
V
Y
M
T
E
A
E
K
I
Q
A
I
I
E
D
I
K
E
R
T
A
K
G
Q
P
V
L
V
G
T
I
S
I
E
K
S
E
L
V
S
N
E
L
----------------------------------------------------------------------------
T
K
A
G
I
K
H
N
V
L
N
A
K
F
H
A
N
E
A
A
I
V
A
Q
A
G
Y
P
A
A
V
T
I
A
T
N
M
A
G
R
G
T
D
I
V
L
G
GS
W
Q
A
E
V
A
A
L
ENPT
A
E
Q
I
E
K
I
K
A
D
W
Q
V
R
H
-------------------------------------
D
--------------------------------------------
A
-----------------------------
V
L
E
A
G
G
L
H
I
I
G
T
E
R
H
E
S
R
R
I
D
N
Q
L
R
G
R
S
G
R
Q
G
D
A
G
S
S
R
F
Y
L
S
M
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
47
HHSearch
64.71
60%
-60
* C4 *
-
3BXZ
2
SECA_ECOLI
B:
[15-458]
-----------
R
N
D
R
T
L
R
R
M
R
K
-
V
V
N
I
I
N
A
M
E
P
E
M
E
K
L
S
D
E
E
L
K
G
K
T
A
E
F
R
A
R
L
E
K
---
G
E
V
L
E
N
L
I
P
E
A
F
A
V
V
R
E
A
S
K
R
V
F
G
M
R
H
F
D
V
Q
L
L
G
G
M
V
L
N
E
R
C
I
A
E
M
R
T
G
E
G
K
T
L
T
A
T
L
P
A
Y
L
N
A
L
T
G
K
G
V
H
V
V
T
V
N
D
Y
L
A
Q
R
D
A
E
N
N
R
P
L
F
E
F
L
G
L
T
V
G
I
---------------
N
L
P
G
M
--------------------------------------------------
P
A
P
A
-----------------------------------
K
R
E
A
Y
A
A
D
I
T
Y
G
T
N
N
E
Y
G
F
D
Y
L
R
D
N
M
A
F
S
P
E
E
R
V
Q
R
---
K
L
H
Y
A
L
V
D
E
V
D
S
I
L
I
D
E
A
R
T
P
L
I
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
S
I
T
F
Q
N
Y
F
R
L
Y
E
K
L
A
G
M
T
G
T
A
D
T
E
A
F
E
F
S
S
I
Y
K
L
D
T
V
V
V
P
T
N
R
P
M
I
R
K
D
L
P
D
L
V
Y
M
T
E
A
E
K
I
Q
A
I
I
E
D
I
K
E
R
T
A
K
G
Q
P
V
L
V
G
T
I
S
I
E
K
S
E
L
V
S
N
E
L
----------------------------------------------------------------------------
T
K
A
G
I
K
H
N
V
L
N
A
K
F
H
A
N
E
A
A
I
V
A
Q
A
G
Y
P
A
A
V
T
I
A
T
N
M
A
G
R
G
T
D
I
V
L
G
------------------------------------------------------------------
G
--------------------------------------------
S
WQAEVAALENPTAEQIEKIKADWQVRHDA
V
L
E
A
G
G
L
H
I
I
G
T
E
R
H
E
S
R
R
I
D
N
Q
L
R
G
R
S
G
R
Q
G
D
A
G
S
S
R
F
Y
L
S
M
E
D
A
L
M
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------