@TOME V2.3
(Mar 2018)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : spr1548: (2018-01-14 )
MKIPLLTFARHKFVYVLLTLLFLALVYRDVLMTYFFFDIHAPDLAKFDGQAIKNDLLKSALDFRILQFNLGFYQSFIIPIIIVLLGFQYIELKNKVLRLSIGREVSYQGLKRKLTLQVASIPCLIYLVTVLIIAIITYFFGTFSPLGWNSLFSDGSGLQRLLDGEIKSYLFFTCVLLIGIFINAIYFLQIVDYVGNVTRSAITYLMFLWLGSMLLYSALPYYMVPMTSLMQASYGDVSLMKLFTPYILYIVPYMVLEKYEDNV
Atome Classification :
(20 SA)
-------------------------------------------------------------------------------------------------------.........-------------10----------------........20........30----......-..40..-----.-...--..50........60........70----.....--------....-------80........--90---------.........-------100---.........110.......--120.....----..130--.......--..140-..---------.....-150...-----------------------....160...---------------....------170--.....------...180...---------------------------....190--------.......----.200---------------------........-----210---.........220..-----.....230.-------...----------...---240..----...-------------..250.......-260.-----------------
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
-------------------------------------------------------------------------------------------------------MKIP
L
L
T
F
A
-------------
R
H
----------------
K
F
V
Y
V
L
L
T
L
L
F
L
A
L
V
Y
R
D
V
L
----
M
T
Y
F
F
F-DIHA
P
D
-----
L
-
A
K
F--D
G
Q
A
I
K
N
D
L
L
K
S
A
L
D
F
R
I
L
Q
F
N
L
-----
G
F
Y
Q
S
--------
F
I
I
P
-------
I
I
I
V
L
L
G
F
Q
Y
--
I
----------
E
LK
N
K
V
L
R
L
-------S-----IGR
E
V
S
Y
Q
GLK
R
K
L
T
L
Q
VA--S
I
P
C
L
I
Y
L
----
V
T
V
----
L
I
I
A
I
I
T
--
Y
F
F
GT-FS---------PLG
W
N
-
S
LFSD
G
-----------------------
S
G
L
Q
R
L
L
D
G
E
---------------
I
K
S
Y
------
L
F
---
F
T
C
V
L
------
L
I
G
I
F
I
N
A
I
---------------------------
Y
F
L
Q
I
-
V
--------
D
Y
V
G
N
V
T
----
R
S
A
----------------------
I
T
Y
L
M
F
L
W
-----
L
-----
G
S
M
L
L
Y
SA
L
P
Y
Y
M
V
-----
P
M
T
S
L
M
Q
AS-------YG
D
----------
V
S
L
---
M
K
L
F
T
----
P
Y
I
-------------
L
Y
I
V
P
Y
M
V
L
E
K
Y-EDNV-----------------
18
Fugue
64.15
21%
-106
- C2 -
-
4OC8
-
?
A:
[2-388]
---------------------------------------------------------------------------TFFTGETLGQVDLIVD
A
V
Y
A
G
Y
K
T
E
RG
G
M
A
D
P
L
V
P
L
V
GVSRQGG
F
R
Y
R
G
T
R
E
----------------
R
P
T
L
L
V
L
T
S
N
L
A
E
P
E
W
P
D
Q
L
DETT
G
T
F
I
Y
Y
G
D
N
R
H
P
G
-----
R
-
L
L
H
--
D
T
P
R
F
G
N
Q
L
L
R
Q
I
F
D
W
A
H
L
G
-----------
Q
R
--------
H
L
V
P
-------
P
I
L
V
F
T
T
----------------
E
A
T
G
R
T
F
R
F
R
G
L
A
V
P
G
S
-----
P
A
L
A
A
T
E
D
L
V
A
L
W
K
T
T
E
G
Q
--
R
F
Q
N
Y
K
A
V
----
F
T
I
----
L
D
E
A
V
I
P
--
R
A
W
V
H
-
A
V
G
R
GETSGLA
P
V
A
W
N
-
A
W
L
S
A
G
G
I
R
P
L
M
A
P
R
S
L
L
V
R
S
K
A
E
Q
L
PAT
P
E
D
Q
A
L
I
E
V
I
---------------
R
Q
R
Y
K
EN
P
F
G
F
E
---
A
C
A
G
A
------
L
T
R
L
L
L
P
D
V
---------------------------
A
R
L
D
L
-
T
R
P
W
RDG
G
R
D
G
I
G
R
L
R
I
G
QS
P
A
A
----------------------
I
E
V
D
F
A
L
E
-----
A
K
CYGA
N
N
A
V
G
V
K
E
V
S
R
L
I
S
R
I
K
HR
E
F
G
V
L
V
T
T
S
-------
Y
V
D
----------
R
Q
A
---
Y
Q
E
V
T
D
D
GH
P
V
I
-------------
L
T
T
A
Q
D
I
V
G
L
L
R
-
S
A
G
V
RT
P
T
Q
V
D
A
W
L
D
G
I
T
A
S
V
15
Fugue
56.37
15%
-55
- C4 -
-
5JX2
3
MGLB_TREPA
A:
[20-387]
-------------------------------------------------------------------------------------------------------
R
D
K
P
L
V
F
F
N
-------------
R
Q
PSDPGKVD
M
A
A
M
N
WND
K
T
Y
Y
V
G
F
D
A
K
F
G
G
S
I
Q
G
K
M
I
----
L
D
F
L
A
S
-
S
E
S
S
V
D
RNGDG
I
-
I
G
Y
--
V
L
C
I
G
D
V
G
H
N
D
S
K
V
R
T
E
G
I
R
R
A
L
-----
G
T
W
T
G
--------
S
S
D
P
GQA
K
E
G
Q
A
V
V
G
G
K
S
Y
K
V
--
V
----------
E
L
E
G
K
A
M
T
G
-------
T
-----
D
G
S
T
W
N
T
N
S
A
T
E
S
M
G
S
W
V
A
--
K
F
A
D
K
I
D
L
----
V
I
S
NN
D
G
M
A
M
G
C
L
Q
AS
N
Y
P
R
G
-
L
P
---------
I
F
G
Y
D
A
N
A
D
A
V
E
-----------------------
S
V
G
K
G
E
L
T
G
T
---------------
V
S
Q
N
------
V
D
---
A
Q
A
V
A
------
V
L
Q
I
I
R
N
L
L
D
GSSG
E
D
V
V
A
NGISRPDAHGNIS
A
P
V
Q
Y
W
E
D
V
K
A
--------
I
M
A
D
N
S
E
----
V
T
S
ANWKEYTRGARDAGVRQVS
A
P
T
K
K
V
L
L
T
V
H
NASN
D
F
-----
L
A
S
A
Y
L
P
A
L
K
H
Y
A
P
-----
L
L
N
V
D
L
T
V
V
-------
Q
G
D
GQN
E
L
S
C
L
D
K
F
T
N
---
L
D
M
F
D
----
A
F
A
-------------
V
N
M
V
K
T
N
S
G
A
D
Y
-
T
D
K
L
K
Y---------------
14
Fugue
55.65
14%
-102
- C4 -
-
5SV0
-
EXBB_ECOLI
A:
[2-234]
---------------------------------------------------------------------------------------------------GNNL
M
Q
T
D
L
S
V
W
G
-------------
M
Y
----------------
Q
H
A
D
I
V
V
K
C
V
M
I
G
L
I
L
A
S
V
V
----
T
W
A
I
F
F
-
S
K
S
V
E
F
-----
F
-
N
Q
K
--
R
R
L
K
R
E
Q
Q
L
L
A
E
A
R
S
L
N
Q
A
N
D
I
A
-----
A
D
F
G
S
--------
K
S
L
S
-------
L
H
L
L
N
E
A
Q
N
E
--
L
----------
E
L
S
E
G
S
D
D
N
-------
E
-----
G
I
E
R
T
S
F
R
L
E
R
R
V
A
A
V
G
R
Q
--
M
G
R
G
N
G
Y
L
----
A
T
I
----
G
A
I
S
P
F
V
--
G
L
F
G
T
-
V
-------------
W
G
-
I
M
N
S
F
I
-----------------------
G
I
A
Q
T
Q
T
T
N
-------------------------------------------
L
A
V
V
A
P
G
I
---------------------------
A
E
A
L
L
-
A
--------
T
A
I
G
L
V
A
----
A
I
P
----------------------
A
V
V
I
Y
N
V
F
-----
A
-----
R
Q
I
G
G
F
K
A
M
L
G
D
V
A
-----
A
Q
V
L
L
L
Q
S
R
-------
D
L
D
----------
L
E
A
---
S
A
A
A
H
----
P
-------------------------------------------------
20
Fugue
53.29
18%
-33
- C1 -
-
4CG4
-
MEFV_HUMAN
A:
[2-377]
------------------------------------------------------------------------S
E
V
A
L
E
H
K
K
K
I
Q
K
Q
L
E
H
L
K
K
L
R
K
S
G
E
E
Q
R
S
Y
G
E
E
K
A
V
S
F
L
-------------
K
Q
----------------
T
E
A
L
K
Q
R
V
Q
R
K
L
E
Q
V
Y
Y
F
L
E
----
Q
Q
E
H
F
F
-
V
A
S
L
E
D
-----
V
-
G
Q
M
--
V
G
Q
I
R
K
A
Y
D
T
R
V
S
Q
D
I
A
L
L
D
A
L
I
-----
G
E
L
E
A
K
E
C
QS
E
W
E
L
L
Q
D
-------
I
G
D
I
L
H
R
A
K
T
--
V
PV
P
E
K
W
T
T
P
Q
E
I
K
Q
K
I
Q
L
L
-------
H
Q
K
S
E
F
V
E
K
S
T
K
Y
F
S
E
T
L
R
S
E
M
E
M
F
--
N
V
P
E
L
I
G
A
Q
A
H
A
V
N
V
----
I
L
D
A
E
T
A
--
Y
P
N
L
I
-
F
S
---------
D
--
D
L
-
K
S
V
R
L
G
-----------------------
N
K
W
E
R
L
P
D
G
P
QRFDSCI
I
V
L
G
S
PSF
L
S
G
R
------
R
Y
---
W
E
V
E
V
GDKT
A
W
I
L
G
A
C
K
T
S
I
SRKGNMTLSPENG--------------
Y
W
V
V
I
-
M
--------
M
K
E
N
E
Y
Q
----
A
S
S
----------------------
V
P
P
T
R
L
L
I
-----
K
-----
E
P
P
K
R
V
G
I
F
V
D
Y
R
V
-----
G
S
I
S
F
Y
N
V
T
ARSHIYT
F
A
S
----------
C
S
F
---
S
G
P
L
Q
----
P
I
F
S
PGTRDGGKNT
A
P
L
T
I
C
P
V
G
G
Q
G
P
D
-
A
L
E
V
LFQ--------------
12
Fugue
45.60
13%
-136
- C4 -
-
4OR2
9
C562_ECOLX (first)
A:
[5-372]
D
L
E
D
N
W
E
T
L
N
D
N
L
K
V
I
E
K
ADN
A
A
Q
V
K
D
A
L
T
K
M
R
A
A
A
L
D
A
Q
K
ATPPKLEDKSPDS
P
E
M
K
D
F
R
H
G
F
D
I
L
V
G
Q
I
D
D
A
L
K
L
A
N
E
GK
V
K
E
A
Q
A
A
A
E
Q
L
K
T
T
R
N
A
YI
Q
K
Y
L
I
P
V
R
Y
L
E
-------------
W
S
----------------
N
I
E
S
I
I
A
I
A
F
S
C
L
G
I
L
V
T
L
F
----
V
T
L
I
F
V
-
L
Y
R
D
T
P
-----
V
-
V
K
S
--
S
S
R
E
L
C
Y
I
I
L
A
G
I
F
L
G
Y
V
C
P
F
T
L
I
AKPT
T
T
S
C
Y
--------
L
Q
R
L
-------
L
V
G
L
S
S
A
M
C
Y
--
S
----------
A
L
V
T
K
T
N
R
I
-------
A
-----
R
I
L
A
R
K
P
R
F
M
S
A
W
A
Q
V
I
I
A
--
S
I
L
I
S
V
Q
L
----
T
L
V
----
V
T
L
I
I
M
E
---------
P
---------
P
---
M
-
P
I
L
S
Y
P
-----------------------
S
I
K
E
V
Y
L
I
C
N
---------------
T
S
N
L
------
G
V
---
V
A
P
L
G
------
Y
N
G
L
L
I
M
S
C
---------------------------
T
Y
Y
A
F
-
K
--------
T
R
N
V
P
A
N
----
F
N
E
----------------------
A
K
Y
I
A
F
T
M
-----
Y
-----
T
T
C
I
I
W
L
A
F
V
P
I
Y
F
-----
G
S
N
Y
K
I
I
T
T
-------
C
F
A
----------
V
S
L
S
--
V
T
V
A
L
----
G
C
M
-------------
F
T
P
K
M
Y
I
I
I
A
K
P
-
E
--------------------
17
Fugue
43.33
15%
-64
- C4 -
-
5T1O
-
PT1P_ECOLI
B:
[2-256]
--------------------------------------------------------------------------------------------------------
R
I
R
A
L
P
A
A
-------------
P
G
-------------------------
V
A
I
A
E
G
W
Q
D
A
T
----
L
P
L
M
E
Q
-
V
Y
Q
A
S
T
-----
L
D
P
A
L
--
E
R
E
R
L
T
G
A
L
E
E
A
A
N
E
F
R
R
Y
S
K
R
F
-----
A
A
G
A
Q
--------
K
E
T
A
-------
A
I
F
D
L
Y
S
H
L
L
S
D
T
----------
R
L
R
R
E
L
F
A
E
-------
V
-----
D
K
G
S
V
A
E
W
A
V
K
T
V
I
E
K
F
A
E
--
Q
F
A
A
L
S
D
---------------
N
Y
L
K
--
E
R
A
G
D
-
L
R
---------
A
L
G
Q
R
-
L
L
F
H
L
D
-----------------------
D
A
N
Q
G
P
N
A
W
P
---------------
E
R
F
I
------
L
V
A
DE
L
S
A
T
T
------
L
A
E
L
P
Q
D
R
L
---------------------------
V
G
V
V
V
-
R
--------
D
--
G
A
A
N
----
S
Q
A
----------------------
A
I
M
V
R
A
L
G
-----
I
-----
P
T
V
M
G
A
D
I
Q
P
S
V
L
H
-----
R
R
T
L
I
V
D
G
Y
-------
R
G
E
----------
L
L
V
DPE
P
V
L
L
Q
----
E
Y
Q
-------------
R
L
I
S
E
E
I
E
L
S
R
L
A
E
D
D
V
N----------------
13
Fugue
40.81
14%
-21
- C4 -
-
4WPC
1
RGD1_YEAST
A:
[14-310]
------------------------------------------------------------------------------------------------FST
P
E
I
K
K
V
L
N
S
D
V
A
I
-------------
N
A
----------------
L
L
S
R
L
K
Q
S
L
L
T
C
E
E
F
M
K
F
I
R
----
K
K
Y
A
F
E
-
E
E
H
V
Q
E
-----
L
-
S
K
Q
Y
K
H
F
F
N
I
Q
N
S
S
L
K
K
M
I
H
-
E
V
L
G
F
D
G
-----
K
M
A
Q
----------
V
K
Q
-------
S
Y
I
T
A
L
Q
K
M
Y
--
S
----------
E
I
S
S
L
L
L
T
M
-------
T
-----
K
L
R
K
S
V
K
E
N
S
K
R
L
E
K
D
V
S
D
--
A
I
H
S
A
E
K
A
----
Q
S
R
----
Y
N
S
L
C
Q
D
--
W
D
K
L
R
-
K
T
---------
K
L
T
L
R
-
G
S
K
T
T
K
-----------------------
E
Q
E
E
E
L
L
R
K
I
---------------
D
N
A
D
------
L
E
---
Y
K
Q
K
V
------
D
H
S
N
S
L
R
N
T
---------------------------
F
I
T
K
E
-
R
--------
P
R
I
V
Q
E
L
----
K
D
L
----------------------
I
L
E
I
D
T
A
M
-----
T
-----
I
Q
L
Q
K
Y
T
I
W
T
E
N
L
V
-----
L
N
T
G
V
T
I
S
P
-------
L
D
S
----------
T
K
S
---
M
K
S
F
A
----
G
S
V
S------------
N
E
R
D
L
Y
S
F
L
N
K
Y
-
N
Q
L
I
NKNLI
P
V
S
Y
K
K
H
P----
1
PsiBlast_PDB
39.43
35%
-264
- C3 -
-
2J49
-
TAF5_YEAST
A:
[178-217]
-------------------------------------------------------------------------------------------------------------------------------------------------
M
Y
P
I
F
I
Y
L
F
L
N
L
V
A
K
N
P
V
----
Y
A
R
R
F
F
-
D
R
F
S
P
D
-----
F
-
K
D
F
--
H
G
S
E
I
N
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
HHSearch
31.76
12%
-248
* C3 *
-
5G4D
-
?
A:
[5-37]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
V
V
I
V
Y
-
D
V
A
V
-
E
--------
R
V
----
N
R
V
K
K
F
L
R
R
H
L
H
W
V
Q
N
S
V
F
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
HHSearch
31.46
14%
-314
- C5 -
-
3DJM
-
?
B:
[40-53]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
P
V
I
Y
F
-----
P
R
E
D
V
A
M
---------------------------------------------------------------------------------------
8
HHSearch
31.45
14%
-314
* C5 *
-
3DJM
-
?
D:
[40-53]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
P
V
I
Y
F
-----
P
R
E
D
V
A
M
---------------------------------------------------------------------------------------
3
HHSearch
29.46
11%
-54
- C3 -
-
1HY5
-
B:
[2116-2133]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
Y
M
Q
Q
-----
L
-
N
S
L
--
D
A
E
M
L
Q
K
N
H
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
HHSearch
29.14
29%
-318
- C3 -
-
2N7I
-
A:
[18-31]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
A
----------------------
V
I
C
L
I
I
V
W
-----
A
-----
V
A
L
--------------------------------------------------------------------------------------------------------------
16
Fugue
27.21
18%
-186
- C4 -
-
1ECI
-
ECAA_ECTTU
A:
[1-37]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
V
-
I
P
---------
K
K
I
W
E
-
T
V
C
P
T
V
-----------------------
E
P
W
A
K
K
C
S
G
D
---------------
I
A
T
Y
------
I
K
---
R
E
C
G
K
------
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
HHSearch
26.25
18%
66
- C3 -
-
1HE1
-
?
A:
[25-41]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
A
S
E
-----
L
-
A
T
L
--
T
P
E
G
L
A
R
E
H
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
HHSearch
21.84
17%
-236
- C3 -
-
4L6R
-
GLR_HUMAN
A:
[245-268]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
----
S
F
F
----------------------
S
L
Y
L
G
I
G
W
-----
G
-----
A
-
P
M
L
F
V
V
P
W
A
V
-----------------------------------------------------------------------------------------------------
4
HHSearch
20.79
11%
122
- C3 -
-
1HY5
-
YOPE_YERPE
A:
[1116-1133]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
Y
M
Q
Q
-----
L
-
N
S
L
--
D
A
E
M
L
Q
K
N
H
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
HHSearch
17.65
25%
-182
- C3 -
-
5C1M
2
OPRM_MOUSE
A:
[188-207]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
A
--------
F
I
M
P
-------
V
L
I
I
T
V
C
Y
G
L
--
M
----------
I
L
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
HHSearch
15.60
7%
-45
- C3 -
-
2ONK
-
WTPB_ARCFU
D:
[24-85]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
R
L
L
F
S
AL
L
A
L
L
S
S
I
I
----
L
L
F
----
V
L
L
P
V
A
A
--
T
V
T
L
Q
L
F
N
---------
F
D
E
F
L
-
K
A
A
S
D
P
-----------------------
A
V
W
K
V
V
L
T
T
Y
---------------
Y
A
A
L
------
I
S
---
T
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
Fugue
12.60
20%
56
* C4 *
-
1Q90
2
?
R:
[3-41]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
S
E
-----
V
-
P
D
M
--
N
K
R
N
I
M
N
L
I
L
A
G
G
A
G
L
P
I
T
T
L
A
L
-----
G
Y
G
A
F
--------
F
V
P
P
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------