@TOME V2.3
(Mar 2018)
Ref.
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : spr1577: (2018-01-15 )
MIQIGKIFAGRYRIVKQIGRGGMADVYLAKDLILDGEEVAVKVLRTNYQTDPIAVARFQREARAMADLDHPHIVRITDIGEEDGQQYLAMEYVAGLDLKRYIKEHYPLSNEEAVRIMGQILLAMRLAHTRGIVHRDLKPQNILLTPDGTAKVTDFGIAVAFAETSLTQTNSMLGSVHYLSPEQARGSKATVQSDIYAMGIIFYEMLTGHIPYDGDSAVTIALQHFQNPLPSVIAENSSVPQALENVIIKATAKKLTNRYRSVSEMYVDLSSSLSYNRRNESKLIFDETSKADTKTLPKVSQSTLTSIPKVQAQTEHKSIKNPSQAVTEETYQPQAPKKHRFKMRYLILLASLVLVAASLIWILSRTPATIAIPDVAGQTVAEAKATLKKANFEIGEEKTEASEKVEEGRIIRTDPGAGTGRKEGTKINLVVSSGKQSFQISNYVGRKSSDVIAELKEKKVPDNLIKIEEEESNESEAGTVLKQSLPEGTTYDLSKATQIVLTVAKKATTIQLGNYIGRNSTEVISELKQKKVPENLIKIEEEESSESEPGTIMKQSPGAGTTYDVSKPTQIVLTVAKKVTSVAMPSYIGSSLEFTKNNLIQIVGIKEANIEVVEVTTAPAGSVEGMVVEQSPRAGEKVDLNKTRVKISIYKPKTTSATP
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70........80..----...----...90........100.......110.......120.......130.......140.....---..150.......160.......170.......180.......190........200.......210.......220...-....230....-....240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
M
I
Q
I
G
K
I
F
A
G
R
Y
R
I
V
K
Q
IGRGGMA
D
V
Y
L
A
K
D
LILD
G
E
E
V
A
V
K
V
L
RTNYQTD
P
I
A
V
A
R
F
Q
R
E
A
R
A
M
ADLDHP
H
I
V
R
I
T
DI
G
E
E
D----
G
Q
Q
----
Y
L
A
M
E
Y
V
AGL
D
L
K
R
Y
I
K
E
HYPL
S
N
E
E
A
V
R
I
M
G
Q
I
L
L
A
M
R
L
A
H
TR
G
I
V
HRDLKPQ
N
I
L
LTPD---GT
A
K
V
T
D
F
G
I
A
V
A
F
AETSLT
Q
T
N
S
MLGSVHYL
S
P
E
QARGSKA
T
-
V
Q
S
D
I
Y
A
M
G
I
I
F
Y
E
M
L
TGHIPYDGDS
A
V
T
I
A
L
Q
H
F-QNP
L
P
S
-
V
IAE-NSS
V
P
Q
A
L
E
N
V
I
I
K
A
T
A
K
K
L
T
N
R
Y
R
S
V
S
E
M
Y
V
D
L
S
SSLSYNRRNE
S
K
L
I
F
DETSKADTKTLPKV
S
Q
S
T
L
TSIPK
V
Q
AQTEHKSIKN
P
S
Q
A
VTEETYQPQAPK
K
H
R
F
K
M
R
Y
L
I
L
L
A
S
L
V
L
V
A
A
S
L
I
W
I
LSRT
P
A
T
I
A
IPDVAG
Q
T
V
A
E
A
K
A
T
L
K
KANFEIGEEKT
E
A
S
E
K
VEEG
R
I
I
R
TDPGAGTGRKEG
T
K
I
N
L
V
VSSGK
Q
S
F
Q
ISNYVGRK
S
S
D
V
I
A
E
L
K
EKKVPDN
L
I
K
IEEEESNE
S
E
A
G
T
V
L
K
Q
SLPEGTTY
D
L
SK
A
T
Q
I
V
L
T
VAK
K
A
T
T
I
Q
LGNYIGR
N
S
T
E
V
I
S
E
L
K
Q
KKV
P
E
N
L
I
KIEEEESSESEPG
T
I
M
KQSPGAGT
T
Y
DVSKP
T
Q
I
V
L
T
V
A
K
K
V
T
S
V
A
M
P
S
YIGSS
L
E
FTKN
N
L
I
Q
I
V
G
I
KEA
N
I
E
V
V
E
V
TTAPAGSV
E
G
M
V
VEQSPRAG
E
K
VDLN
K
T
R
V
K
I
S
I
YKPKTTSATP
22
PsiBlast_CBE
87.93
47%
-94
- C2 -
-
4EQM
1
?
E:
[5-282]
---
I
G
K
I
I
N
E
R
Y
K
I
V
D
K
L
G
G
G
G
M
S
T
V
Y
L
A
E
D
T
I
L
N
I
K
-
V
A
I
K
A
I
F
I
P
P
R
E
K
E
E
T
L
K
R
F
E
R
E
V
H
N
S
S
Q
L
S
H
Q
N
I
V
S
M
I
D
V
D
E
E
D
----
D
C
Y
----
Y
L
V
M
E
Y
I
E
G
P
T
L
S
E
Y
I
E
S
H
G
P
L
S
V
D
T
A
I
N
F
T
N
Q
I
L
D
G
I
K
H
A
H
D
M
R
I
V
H
R
D
I
K
P
Q
N
I
L
I
D
S
N
---
K
T
L
K
I
F
D
F
G
I
A
K
---------------
T
V
Q
Y
F
S
P
E
Q
A
K
G
E
A
T
D
-
E
C
T
D
I
Y
S
I
G
I
V
L
Y
E
M
L
V
G
E
P
P
F
N
G
E
T
A
V
S
I
A
I
K
H
I
-
Q
D
S
V
P
N
-
V
T
T
D
V
R
K
D
I
P
Q
S
L
S
N
V
I
L
R
A
T
E
K
D
K
A
N
R
Y
K
T
I
Q
E
M
K
D
D
L
S
S
V
L
H
E
N
R
A
N
E
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
PsiBlast_CBE
87.77
47%
-95
- C2 -
-
4EQM
1
?
D:
[5-282]
---
I
G
K
I
I
N
E
R
Y
K
I
V
D
K
L
G
G
G
G
M
S
T
V
Y
L
A
E
D
T
I
L
N
I
K
-
V
A
I
K
A
I
F
I
P
P
R
E
K
E
E
T
L
K
R
F
E
R
E
V
H
N
S
S
Q
L
S
H
Q
N
I
V
S
M
I
D
V
D
E
E
D
----
D
C
Y
----
Y
L
V
M
E
Y
I
E
G
P
T
L
S
E
Y
I
E
S
H
G
P
L
S
V
D
T
A
I
N
F
T
N
Q
I
L
D
G
I
K
H
A
H
D
M
R
I
V
H
R
D
I
K
P
Q
N
I
L
I
D
S
N
---
K
T
L
K
I
F
D
F
G
I
A
K
---------------
T
V
Q
Y
F
S
P
E
Q
A
K
G
E
A
T
D
-
E
C
T
D
I
Y
S
I
G
I
V
L
Y
E
M
L
V
G
E
P
P
F
N
G
E
T
A
V
S
I
A
I
K
H
I
-
Q
D
S
V
P
N
-
V
T
T
D
V
R
K
D
I
P
Q
S
L
S
N
V
I
L
R
A
T
E
K
D
K
A
N
R
Y
K
T
I
Q
E
M
K
D
D
L
S
S
V
L
H
E
N
R
A
N
E
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
25
PsiBlast_CBE
87.16
47%
-93
- C2 -
-
4EQM
2
?
B:
[5-282]
---
I
G
K
I
I
N
E
R
Y
K
I
V
D
K
L
G
G
G
G
M
S
T
V
Y
L
A
E
D
T
I
L
N
I
K
-
V
A
I
K
A
I
F
I
P
P
R
E
K
E
E
T
L
K
R
F
E
R
E
V
H
N
S
S
Q
L
S
H
Q
N
I
V
S
M
I
D
V
D
E
E
D
----
D
C
Y
----
Y
L
V
M
E
Y
I
E
G
P
T
L
S
E
Y
I
E
S
H
G
P
L
S
V
D
T
A
I
N
F
T
N
Q
I
L
D
G
I
K
H
A
H
D
M
R
I
V
H
R
D
I
K
P
Q
N
I
L
I
D
S
N
---
K
T
L
K
I
F
D
F
G
I
A
K
A
L
-------------
T
V
Q
Y
F
S
P
E
Q
A
K
G
E
A
T
D
-
E
C
T
D
I
Y
S
I
G
I
V
L
Y
E
M
L
V
G
E
P
P
F
N
G
E
T
A
V
S
I
A
I
K
H
I
-
Q
D
S
V
P
N
-
V
T
T
D
V
R
K
D
I
P
Q
S
L
S
N
V
I
L
R
A
T
E
K
D
K
A
N
R
Y
K
T
I
Q
E
M
K
D
D
L
S
S
V
L
H
E
N
R
A
N
E
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
PsiBlast_CBE
87.12
47%
-94
- C2 -
-
4EQM
1
?
F:
[5-282]
---
I
G
K
I
I
N
E
R
Y
K
I
V
D
K
L
G
G
G
G
M
S
T
V
Y
L
A
E
D
T
I
L
N
I
K
-
V
A
I
K
A
I
F
I
P
P
R
E
K
E
E
T
L
K
R
F
E
R
E
V
H
N
S
S
Q
L
S
H
Q
N
I
V
S
M
I
D
V
D
E
E
D
----
D
C
Y
----
Y
L
V
M
E
Y
I
E
G
P
T
L
S
E
Y
I
E
S
H
G
P
L
S
V
D
T
A
I
N
F
T
N
Q
I
L
D
G
I
K
H
A
H
D
M
R
I
V
H
R
D
I
K
P
Q
N
I
L
I
D
S
N
---
K
T
L
K
I
F
D
F
G
I
A
K
---------------
T
V
Q
Y
F
S
P
E
Q
A
K
G
E
A
T
D
-
E
C
T
D
I
Y
S
I
G
I
V
L
Y
E
M
L
V
G
E
P
P
F
N
G
E
T
A
V
S
I
A
I
K
H
I
-
Q
D
S
V
P
N
-
V
T
T
D
V
R
K
D
I
P
Q
S
L
S
N
V
I
L
R
A
T
E
K
D
K
A
N
R
Y
K
T
I
Q
E
M
K
D
D
L
S
S
V
L
H
E
N
R
A
N
E
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
PsiBlast_CBE
86.92
47%
-92
- C2 -
-
4EQM
2
?
C:
[5-282]
---
I
G
K
I
I
N
E
R
Y
K
I
V
D
K
L
G
G
G
G
M
S
T
V
Y
L
A
E
D
T
I
L
N
I
K
-
V
A
I
K
A
I
F
I
P
P
R
E
K
E
E
T
L
K
R
F
E
R
E
V
H
N
S
S
Q
L
S
H
Q
N
I
V
S
M
I
D
V
D
E
E
D
----
D
C
Y
----
Y
L
V
M
E
Y
I
E
G
P
T
L
S
E
Y
I
E
S
H
G
P
L
S
V
D
T
A
I
N
F
T
N
Q
I
L
D
G
I
K
H
A
H
D
M
R
I
V
H
R
D
I
K
P
Q
N
I
L
I
D
S
N
---
K
T
L
K
I
F
D
F
G
I
A
K
A
L
-------------
T
V
Q
Y
F
S
P
E
Q
A
K
G
E
A
T
D
-
E
C
T
D
I
Y
S
I
G
I
V
L
Y
E
M
L
V
G
E
P
P
F
N
G
E
T
A
V
S
I
A
I
K
H
I
-
Q
D
S
V
P
N
-
V
T
T
D
V
R
K
D
I
P
Q
S
L
S
N
V
I
L
R
A
T
E
K
D
K
A
N
R
Y
K
T
I
Q
E
M
K
D
D
L
S
S
V
L
H
E
N
R
A
N
E
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
122
HHSearch
86.08
47%
-95
- C2 -
-
4EQM
2
?
C:
[5-276]
---
I
G
K
I
I
N
E
R
Y
K
I
V
D
K
L
G
G
G
G
M
S
T
V
Y
L
A
E
D
T
I
L
N
-
I
K
V
A
I
K
A
I
F
I
P
P
R
E
K
E
E
T
L
K
R
F
E
R
E
V
H
N
S
S
Q
L
S
H
Q
N
I
V
S
M
I
D
V
D
E
E
D
----
D
C
Y
----
Y
L
V
M
E
Y
I
E
G
P
T
L
S
E
Y
I
E
S
H
G
P
L
S
V
D
T
A
I
N
F
T
N
Q
I
L
D
G
I
K
H
A
H
D
M
R
I
V
H
R
D
I
K
P
Q
N
I
L
I
D
S
N
---
K
T
L
K
I
F
D
F
G
I
A
K
A
L
-------------
T
V
Q
Y
F
S
P
E
Q
A
K
G
E
A
T
D
-
E
C
T
D
I
Y
S
I
G
I
V
L
Y
E
M
L
V
G
E
P
P
F
N
G
E
T
A
V
S
I
A
I
K
H
I
-
Q
D
S
V
P
N
V
T
T
D
V
-
R
K
D
I
P
Q
S
L
S
N
V
I
L
R
A
T
E
K
D
K
A
N
R
Y
K
T
I
Q
E
M
K
D
D
L
S
S
V
L
H
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
85.60
47%
-90
- C2 -
-
4EQM
2
?
A:
[5-282]
---
I
G
K
I
I
N
E
R
Y
K
I
V
D
K
L
G
G
G
G
M
S
T
V
Y
L
A
E
D
T
I
L
N
I
K
-
V
A
I
K
A
I
F
I
P
P
R
E
K
E
E
T
L
K
R
F
E
R
E
V
H
N
S
S
Q
L
S
H
Q
N
I
V
S
M
I
D
V
D
E
E
D
----
D
C
Y
----
Y
L
V
M
E
Y
I
E
G
P
T
L
S
E
Y
I
E
S
H
G
P
L
S
V
D
T
A
I
N
F
T
N
Q
I
L
D
G
I
K
H
A
H
D
M
R
I
V
H
R
D
I
K
P
Q
N
I
L
I
D
S
N
---
K
T
L
K
I
F
D
F
G
I
A
K
A
L
-------------
T
V
Q
Y
F
S
P
E
Q
A
K
G
E
A
T
D
-
E
C
T
D
I
Y
S
I
G
I
V
L
Y
E
M
L
V
G
E
P
P
F
N
G
E
T
A
V
S
I
A
I
K
H
I
-
Q
D
S
V
P
N
-
V
T
T
D
V
R
K
D
I
P
Q
S
L
S
N
V
I
L
R
A
T
E
K
D
K
A
N
R
Y
K
T
I
Q
E
M
K
D
D
L
S
S
V
L
H
E
N
R
A
N
E
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
128
HHSearch
76.08
39%
-31
- C2 -
-
3ORK
2
?
A:
[6-282]
---
T
P
S
H
L
S
D
R
Y
E
L
G
E
I
L
G
F
G
G
M
S
E
V
H
L
A
R
D
L
R
D
H
-
R
D
V
A
V
K
V
L
R
A
D
L
A
R
D
P
S
F
Y
L
R
F
R
R
E
A
Q
N
A
A
A
L
N
H
P
A
I
V
A
V
Y
D
T
G
E
A
E
T
PA
G
P
L
P
----
Y
I
V
M
E
Y
V
D
G
V
T
L
R
D
I
V
H
T
E
G
P
M
T
P
K
R
A
I
E
V
I
A
D
A
C
Q
A
L
N
F
S
H
Q
N
G
I
I
H
R
D
V
K
P
A
N
I
M
I
S
A
T
---
N
A
V
K
V
M
D
F
G
I
A
----------------
T
A
Q
Y
L
S
P
E
Q
A
R
G
D
S
V
D
-
A
R
S
D
V
Y
S
L
G
C
V
L
Y
E
V
L
T
G
E
P
P
F
T
G
D
S
P
V
S
V
A
Y
Q
H
V
-
R
E
D
P
I
P
-
P
S
A
R
-
H
E
G
L
S
A
D
L
D
A
V
V
L
K
A
L
A
K
N
P
E
N
R
Y
Q
T
A
A
E
M
R
A
D
L
V
R
V
H
N
G
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
75.47
41%
-18
- C2 -
-
3ORK
2
?
A:
[10-276]
-------
L
S
D
R
Y
E
L
G
E
I
L
G
F
G
G
M
S
E
V
H
L
A
R
D
L
-
R
D
H
R
D
V
A
V
K
V
L
R
A
D
L
A
R
D
P
S
F
Y
L
R
F
R
R
E
A
Q
N
A
A
A
L
N
H
P
A
I
V
A
V
Y
D
T
G
E
A
E
----
T
P
A
G
P
L
P
Y
I
V
M
E
Y
V
D
G
V
T
L
R
D
I
V
H
T
E
G
P
M
T
P
K
R
A
I
E
V
I
A
D
A
C
Q
A
L
N
F
S
H
Q
N
G
I
I
H
R
D
V
K
P
A
N
I
M
I
S
A
T
---
N
A
V
K
V
M
D
F
G
I
A
----------------
T
A
Q
Y
L
S
P
E
Q
A
R
G
D
S
V
D
-
A
R
S
D
V
Y
S
L
G
C
V
L
Y
E
V
L
T
G
E
P
P
F
T
G
D
S
P
V
S
V
A
Y
Q
H
V
R
E
D
P
I
P
P
-
S
-
A
R
-
H
E
G
L
S
A
D
L
D
A
V
V
L
K
A
L
A
K
N
P
E
N
R
Y
Q
T
A
A
E
M
R
A
D
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
75.28
41%
-12
- C2 -
-
3ORO
2
PKNB_MYCTU
A:
[12-276]
---------
D
R
Y
E
L
G
E
I
L
G
F
G
G
M
S
E
V
H
L
A
R
D
L
-
R
D
H
R
D
V
A
V
K
V
L
R
A
D
L
A
R
D
P
S
F
Y
L
R
F
R
R
E
A
Q
N
A
A
A
L
N
H
P
A
I
V
A
V
Y
D
T
G
E
A
E
----
T
P
A
G
P
L
P
Y
I
V
M
E
Y
V
D
G
V
T
L
R
D
I
V
H
T
E
G
P
M
T
P
K
R
A
I
E
V
I
A
D
A
C
Q
A
L
N
F
S
H
Q
N
G
I
I
H
R
D
V
K
P
A
N
I
M
I
S
A
T
---
N
A
V
K
V
M
D
F
G
I
A
R
A
I
A
------
T
A
A
V
I
G
T
A
Q
Y
L
S
P
E
Q
A
R
G
D
S
V
D
-
A
R
S
D
V
Y
S
L
G
C
V
L
Y
E
V
L
T
G
E
P
P
F
T
G
D
S
P
V
S
V
A
Y
Q
H
V
R
E
D
P
I
P
P
-
S
-
A
R
-
H
E
G
L
S
A
D
L
D
A
V
V
L
K
A
L
A
K
N
P
E
N
R
Y
Q
T
A
A
E
M
R
A
D
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
75.14
41%
-16
- C2 -
-
3ORP
1
?
A:
[10-276]
-------
L
S
D
R
Y
E
L
G
E
I
L
G
F
G
G
M
S
E
V
H
L
A
R
D
L
-
R
D
H
R
D
V
A
V
K
V
L
R
A
D
L
A
R
D
P
S
F
Y
L
R
F
R
R
E
A
Q
N
A
A
A
L
N
H
P
A
I
V
A
V
Y
D
T
G
E
A
E
----
T
P
A
G
P
L
P
Y
I
V
M
E
Y
V
D
G
V
T
L
R
D
I
V
H
T
E
G
P
M
T
P
K
R
A
I
E
V
I
A
D
A
C
Q
A
L
N
F
S
H
Q
N
G
I
I
H
R
D
V
K
P
A
N
I
M
I
S
A
T
---
N
A
V
K
V
M
D
F
G
I
A
--------------
I
G
T
A
Q
Y
L
S
P
E
Q
A
R
G
D
S
V
D
-
A
R
S
D
V
Y
S
L
G
C
V
L
Y
E
V
L
T
G
E
P
P
F
T
G
D
S
P
V
S
V
A
Y
Q
H
V
R
E
D
P
I
P
P
-
S
-
A
R
-
H
E
G
L
S
A
D
L
D
A
V
V
L
K
A
L
A
K
N
P
E
N
R
Y
Q
T
A
A
E
M
R
A
D
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
74.84
41%
-9
- C2 -
-
2FUM
-
PKNB_MYCTU
A:
[27-293]
-------
L
S
D
R
Y
E
L
G
E
I
L
G
F
G
G
M
S
E
V
H
L
A
R
D
L
R
L
H
-
R
D
V
A
V
K
V
L
R
A
D
L
A
R
D
P
S
F
Y
L
R
F
R
R
E
A
Q
N
A
A
A
L
N
H
P
A
I
V
A
V
Y
D
T
G
E
A
E
----
T
P
A
G
P
L
P
Y
I
V
M
E
Y
V
D
G
V
T
L
R
D
I
V
H
T
E
G
P
M
T
P
K
R
A
I
E
V
I
A
D
A
C
Q
A
L
N
F
S
H
Q
N
G
I
I
H
R
D
V
K
P
A
N
I
M
I
S
A
T
---
N
A
V
K
V
M
D
F
G
I
A
R
A
I
A
D
----------
G
T
A
Q
Y
L
S
P
E
Q
A
R
G
D
S
V
D
-
A
R
S
D
V
Y
S
L
G
C
V
L
Y
E
V
L
T
G
E
P
P
F
T
G
D
S
P
V
S
V
A
Y
Q
H
V
R
E
D
P
I
P
P
-
S
-
A
R
-
H
E
G
L
S
A
D
L
D
A
V
V
L
K
A
L
A
K
N
P
E
N
R
Y
Q
T
A
A
E
M
R
A
D
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
74.49
40%
-18
- C2 -
-
3F61
1
PKNB_MYCTU
A:
[10-276]
-------
L
S
D
R
Y
E
L
G
E
I
L
G
F
G
G
M
S
E
V
H
L
A
R
D
L
-
R
D
H
R
D
V
A
V
K
V
L
R
A
D
L
A
R
D
P
S
F
Y
L
R
F
R
R
E
A
Q
N
A
A
A
L
N
H
P
A
I
V
A
V
Y
D
T
G
E
A
E
----
T
P
A
G
P
L
P
Y
I
V
M
E
Y
V
D
G
V
T
L
R
D
I
V
H
T
E
G
P
M
T
P
K
R
A
I
E
V
I
A
D
A
C
Q
A
L
N
F
S
H
Q
N
G
I
I
H
R
D
V
K
P
A
N
I
M
I
S
A
T
---
N
A
V
K
V
M
D
F
G
I
A
-----------------
A
Q
Y
L
S
P
E
Q
A
R
G
D
S
V
D
-
A
R
S
D
V
Y
S
L
G
C
V
L
Y
E
V
L
T
G
E
P
P
F
T
G
D
S
P
D
S
V
A
Y
Q
H
V
R
E
D
P
I
P
P
-
S
-
A
R
-
H
E
G
L
S
A
D
L
D
A
V
V
L
K
A
L
A
K
N
P
E
N
R
Y
Q
T
A
A
E
M
R
A
D
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
73.95
41%
-12
- C2 -
-
3ORT
2
?
A:
[10-276]
-------
L
S
D
R
Y
E
L
G
E
I
L
G
F
G
G
M
S
E
V
H
L
A
R
D
L
-
R
D
H
R
D
V
A
V
K
V
L
R
A
D
L
A
R
D
P
S
F
Y
L
R
F
R
R
E
A
Q
N
A
A
A
L
N
H
P
A
I
V
A
V
Y
D
T
G
E
A
E
----
T
P
A
G
P
L
P
Y
I
V
M
E
Y
V
D
G
V
T
L
R
D
I
V
H
T
E
G
P
M
T
P
K
R
A
I
E
V
I
A
D
A
C
Q
A
L
N
F
S
H
Q
N
G
I
I
H
R
D
V
K
P
A
N
I
M
I
S
A
T
---
N
A
V
K
V
M
D
F
G
I
A
R
----------------
A
Q
Y
L
S
P
E
Q
A
R
G
D
S
V
D
-
A
R
S
D
V
Y
S
L
G
C
V
L
Y
E
V
L
T
G
E
P
P
F
T
G
D
S
P
V
S
V
A
Y
Q
H
V
R
E
D
P
I
P
P
-
S
-
A
R
-
H
E
G
L
S
A
D
L
D
A
V
V
L
K
A
L
A
K
N
P
E
N
R
Y
Q
T
A
A
E
M
R
A
D
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
73.56
41%
-16
- C2 -
-
1O6Y
1
PKNB_MYCTU
A:
[27-293]
-------
L
S
D
R
Y
E
L
G
E
I
L
G
F
G
G
M
S
E
V
H
L
A
R
D
L
R
L
H
-
R
D
V
A
V
K
V
L
R
A
D
L
A
R
D
P
S
F
Y
L
R
F
R
R
E
A
Q
N
A
A
A
L
N
H
P
A
I
V
A
V
Y
D
T
G
E
A
E
----
T
P
A
G
P
L
P
Y
I
V
M
E
Y
V
D
G
V
T
L
R
D
I
V
H
T
E
G
P
M
T
P
K
R
A
I
E
V
I
A
D
A
C
Q
A
L
N
F
S
H
Q
N
G
I
I
H
R
D
V
K
P
A
N
I
M
I
S
A
T
---
N
A
V
K
V
M
D
F
G
I
A
R
A
I
A
--------------
Q
Y
L
S
P
E
Q
A
R
G
D
S
V
D
-
A
R
S
D
V
Y
S
L
G
C
V
L
Y
E
V
L
T
G
E
P
P
F
T
G
D
S
P
V
S
V
A
Y
Q
H
V
R
E
D
P
I
P
P
-
S
-
A
R
-
H
E
G
L
S
A
D
L
D
A
V
V
L
K
A
L
A
K
N
P
E
N
R
Y
Q
T
A
A
E
M
R
A
D
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
70.08
40%
-26
- C2 -
-
3ORM
1
?
A:
[13-276]
----------
R
Y
E
L
G
E
I
L
G
F
G
G
M
S
E
V
H
L
A
R
D
L
R
L
H
-
R
D
V
A
V
K
V
L
R
A
D
L
A
R
D
P
S
F
Y
L
R
F
R
R
E
A
Q
N
A
A
A
L
N
H
P
A
I
V
A
V
Y
A
T
G
E
A
E
----
T
P
A
G
P
L
P
Y
I
V
M
E
Y
V
D
G
V
T
L
R
D
I
V
H
T
E
G
P
M
T
P
K
R
A
I
E
V
I
A
D
A
C
Q
A
L
N
F
S
H
Q
N
G
I
I
H
R
D
V
K
P
A
N
I
M
I
S
A
T
---
N
A
V
K
V
M
D
F
G
I
A
R
A
I
A
------------
T
A
Q
Y
L
S
P
E
Q
A
R
G
D
S
V
D
-
A
R
S
D
V
Y
S
L
G
C
V
L
Y
E
V
L
T
G
E
P
P
F
T
G
D
S
P
V
S
V
A
Y
Q
H
V
R
E
D
P
I
P
P
-
S
-
A
R
-
H
E
G
L
S
A
D
L
D
A
V
V
L
K
A
L
A
K
N
P
E
N
R
Y
Q
T
A
A
E
M
R
A
D
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
66.41
36%
-109
- C2 -
-
3IEC
-
MARK2_HUMAN
A:
[7-210]
---------
G
N
Y
R
L
L
K
T
I
G
----
A
K
V
K
L
A
R
H
-
I
L
T
G
K
E
V
A
V
K
I
I
D
K
T
-
Q
L
N
S
S
S
L
Q
K
L
F
R
E
V
R
I
M
K
V
L
N
H
P
N
I
V
K
L
F
E
V
I
E
T
E
----
K
T
L
----
Y
L
V
M
E
Y
A
S
G
G
E
V
F
D
Y
L
V
A
H
G
W
M
K
E
K
E
A
R
A
K
F
R
Q
I
V
S
A
V
Q
Y
C
H
Q
K
F
I
V
H
R
D
L
K
A
E
N
L
L
L
D
A
D
---
M
N
I
K
I
A
D
F
G
F
S
N
E
F
--
T
F
G
N
K
L
D
T
F
C
G
S
P
P
Y
A
A
P
E
L
F
Q
G
K
K
Y
D
G
P
E
V
D
V
W
S
L
G
V
I
L
Y
T
L
V
S
G
S
L
P
F
D
G
Q
N
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
115
HHSearch
65.29
29%
-72
- C2 -
-
2WEL
7
KCC2D_HUMAN
A:
[2-264]
-------
M
T
D
E
Y
Q
L
F
E
E
L
G
K
G
A
F
S
V
V
R
R
C
M
K
I
P
T
G
-
Q
E
Y
A
A
K
I
I
N
T
K
K
L
-
S
A
R
D
H
Q
K
L
E
R
E
A
R
I
C
R
L
L
K
H
P
N
I
V
R
L
H
D
S
I
S
E
E
----
G
F
H
----
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
E
Y
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
L
N
G
I
V
H
R
D
L
K
P
E
N
L
L
L
A
S
K
SKG
A
A
V
K
L
A
D
F
G
L
A
I
E
V
Q
G
D
Q
-
Q
A
W
F
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
R
K
D
P
Y
G
-
K
P
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
D
E
D
Q
H
R
L
Y
Q
Q
I
K
-
A
G
A
Y
D
F
-
P
S
P
E
-
W
D
T
V
T
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
A
K
R
I
T
-
A
S
E
A
L
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
64.52
36%
-99
- C- -
-
3FE3
-
MARK3_HUMAN
A:
[54-257]
---------
G
N
Y
R
L
L
K
T
I
G
K
G
N
F
A
K
V
K
L
A
R
H
-
I
L
T
G
R
E
V
A
I
K
I
I
D
K
T
-
Q
L
N
P
T
S
L
Q
K
L
F
R
E
V
R
I
M
K
I
L
N
H
P
N
I
V
K
L
F
E
V
I
E
T
E
----
K
T
L
----
Y
L
I
M
E
Y
A
S
G
G
E
V
F
D
Y
L
V
A
H
G
R
M
K
E
K
E
A
R
S
K
F
R
Q
I
V
S
A
V
Q
Y
C
H
Q
K
R
I
V
H
R
D
L
K
A
E
N
L
L
L
D
A
D
---
M
N
I
K
I
A
D
F
G
F
S
N
E
F
--
T
V
G
G
K
L
D
A
F
C
G
A
P
P
Y
A
A
P
E
L
F
Q
G
K
K
Y
D
G
P
E
V
D
V
W
S
L
G
V
I
L
Y
T
L
V
S
G
S
L
P
F
D
G
Q
N
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
64.36
36%
-100
- C2 -
-
2QNJ
-
MARK3_HUMAN
A:
[54-257]
---------
G
N
Y
R
L
L
K
T
I
G
K
G
N
F
A
K
V
K
L
A
R
H
-
I
L
T
G
R
E
V
A
I
K
I
I
D
K
T
-
Q
L
N
P
T
S
L
Q
K
L
F
R
E
V
R
I
M
K
I
L
N
H
P
N
I
V
K
L
F
E
V
I
E
T
E
----
K
T
L
----
Y
L
I
M
E
Y
A
S
G
G
E
V
F
D
Y
L
V
A
H
G
R
M
K
E
K
E
A
R
S
K
F
R
Q
I
V
S
A
V
Q
Y
C
H
Q
K
R
I
V
H
R
D
L
K
A
E
N
L
L
L
D
A
D
---
M
N
I
K
I
A
D
F
G
F
S
N
E
F
--
T
-----
D
T
F
C
G
S
P
P
Y
A
A
P
E
L
F
Q
G
K
K
Y
D
G
P
E
V
D
V
W
S
L
G
V
I
L
Y
T
L
V
S
G
S
L
P
F
D
G
Q
N
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------