@TOME V2.3
(Mar 2018)
Ref.
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : spr1634: (2018-01-16 )
MSQEFLARILEQKAREVEQMKLEQIQPLRQTYRLAEFLKNHQDCLQVIAEVKKASPSLGDINLDVDIVQQAQTYEENGAVMISVLTDEVFFKGHLDYLREISSQVEIPTLNKDFIIDEKQIIRARNAGATVILLIVAALSEERLKELYDYATELGLEVLVETHNLAELEVAHRLGAEIIGVNNRNLTTFEVDLQTSVDLAPYFEEGRYYISESAIFTGQDAERLAPYFNGILVGTALMQAENVVQRIKELQIDKG
Atome Classification :
(25 SA)
.........10........20....-...--.30...----------.....40--.....-----...50........60........70........80........90........100.......110.......120.......130.......140......-.150.......160.......-170.......180.......190.......200..---.---....210.......220.....----..230........240.......250...
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
M
S
Q
E
F
L
A
R
I
L
E
Q
K
A
R
E
V
E
Q
M
K
L
E
Q
I
-
Q
P
L
--
R
Q
T
Y
R
L
----------
A
E
F
L
K
N
H
--
Q
D
C
L
Q
-----
V
I
A
E
V
K
KASPSLG
D
I
N
L
D
V
D
I
V
Q
Q
A
Q
T
YEENG
A
V
M
I
S
VLTD
E
V
F
F
K
G
H
L
D
Y
L
R
E
I
S
SQVEIPTLNKDFII
D
E
K
Q
I
I
R
ARNAG
A
T
V
I
L
L
I
V
A
A
L
S
E
E
R
L
K
E
L
Y
-
D
Y
A
T
E
L
G
L
E
V
L
V
ETH
N
L
A
E
L
E
-
V
A
H
RLG
A
E
I
I
GVNNR
N
L
T
T
F
E
V
D
LQTSVDLAPYFE---E---
G
R
Y
Y
ISES
A
I
FTGQ
D
A
E
R
L
A
P
Y
----
F
N
G
-
I
L
V
G
T
A
L
M
Q
A
E
N
V
V
Q
R
I
K
E
LQIDKG
2
PsiBlast_PDB
83.49
36%
-82
- C6 -
-
1I4N
-
TRPC_THEMA
A:
[3-247]
-----
L
W
E
I
V
E
A
K
K
K
D
I
L
E
I
D
G
E
N
L
-
I
V
Q
--
R
R
N
H
R
F
----------
L
E
V
L
-
S
G
--
K
E
R
V
K
-----
I
I
A
E
F
K
K
A
S
P
S
A
G
D
I
N
A
D
A
S
L
E
D
F
I
R
M
Y
D
E
-
L
A
D
A
I
S
I
L
T
E
K
H
Y
F
K
G
D
P
A
F
V
R
A
A
R
N
L
T
C
R
P
I
L
A
K
D
F
Y
I
D
T
V
Q
V
K
L
A
S
S
V
G
A
D
A
I
L
I
I
A
R
I
L
T
A
E
Q
I
K
E
I
Y
-
E
A
A
E
E
L
G
M
D
S
L
V
E
V
H
S
R
E
D
L
E
K
V
F
S
V
I
R
P
K
I
I
G
I
N
T
R
D
L
D
T
F
E
I
K
K
N
V
L
W
E
L
L
P
L
V
P
---
D
---
D
T
V
V
V
A
E
S
G
I
K
D
P
R
E
L
K
D
L
R
G
K
----
V
N
A
-
V
L
V
G
T
S
I
M
K
A
E
N
P
R
R
F
L
E
E
M
R
----
1
PsiBlast_PDB
80.93
42%
-102
- C6 -
-
3TSM
1
TRPC_BRUA2
A:
[61-265]
------------------------------------------------------------------
L
I
A
E
I
K
K
A
S
P
S
K
G
L
I
R
P
D
F
D
P
P
A
L
A
K
A
Y
E
E
G
G
A
A
C
L
S
V
L
T
D
T
P
S
F
Q
G
A
P
E
F
L
T
A
A
R
Q
A
C
S
L
P
A
L
R
K
D
F
L
F
D
P
Y
Q
V
Y
E
A
R
S
W
G
A
D
C
I
L
I
I
M
A
S
V
D
D
D
L
A
K
E
L
E
-
D
T
A
F
A
L
G
M
D
A
L
I
E
V
H
D
E
A
E
M
E
-
R
A
L
K
L
S
S
R
L
L
G
V
N
N
R
N
L
R
S
F
E
V
N
L
A
V
S
E
R
L
A
K
M
A
P
---
S
---
D
R
L
L
V
G
E
S
G
I
F
T
H
E
D
C
L
R
L
E
K
S
----
G
I
G
T
F
L
I
G
E
S
L
M
R
Q
H
D
V
A
A
A
T
R
A
L
-----
21
PsiBlast_CBE
80.02
42%
-99
- C6 -
-
3TSM
3
TRPC_BRUA2
B:
[61-265]
------------------------------------------------------------------
L
I
A
E
I
K
K
A
S
P
S
K
G
L
I
R
P
D
F
D
P
P
A
L
A
K
A
Y
E
E
G
G
A
A
C
L
S
V
L
T
D
T
P
S
F
Q
G
A
P
E
F
L
T
A
A
R
Q
A
C
S
L
P
A
L
R
K
D
F
L
F
D
P
Y
Q
V
Y
E
A
R
S
W
G
A
D
C
I
L
I
I
M
A
S
V
D
D
D
L
A
K
E
L
E
-
D
T
A
F
A
L
G
M
D
A
L
I
E
V
H
D
E
A
E
M
E
-
R
A
L
K
L
S
S
R
L
L
G
V
N
N
R
N
L
R
S
F
E
V
N
L
A
V
S
E
R
L
A
K
M
A
P
---
S
---
D
R
L
L
V
G
E
S
G
I
F
T
H
E
D
C
L
R
L
E
K
S
----
G
I
G
T
F
L
I
G
E
S
L
M
R
Q
H
D
V
A
A
A
T
R
A
L
-----
15
PsiBlast_PDB
79.98
36%
-114
- C6 -
-
1A53
1
TRPC_SULSO
A:
[35-245]
-----------------------------------
R
I
----------
L
E
F
--
N
K
--
R
N
I
T
A
-----
I
I
A
E
Y
K
R
K
S
P
S
--
G
L
D
V
E
R
D
P
I
E
Y
S
K
-
F
M
E
R
Y
A
V
G
L
S
I
L
T
E
E
K
Y
F
N
G
S
Y
E
T
L
R
K
I
A
S
S
V
S
I
P
I
L
M
K
D
F
I
V
K
E
S
Q
I
D
D
A
Y
N
L
G
A
D
T
V
L
L
I
V
K
I
L
T
E
R
E
L
E
S
L
L
-
E
Y
A
R
S
Y
G
M
E
P
L
I
E
I
N
D
E
N
D
L
D
-
I
A
L
R
I
G
A
R
F
I
G
I
N
S
R
D
L
E
T
L
E
I
N
K
E
N
Q
R
K
L
I
S
M
I
P
---
S
---
N
V
V
K
V
A
E
S
G
I
S
E
R
N
E
I
E
E
L
R
K
L
G---
V
N
A
-
F
L
I
G
S
S
L
M
R
N
P
---
E
K
I
K
E
F
-----
13
PsiBlast_PDB
79.86
36%
-112
- C6 -
-
1LBF
1
TRPC_SULSO
A:
[35-245]
-----------------------------------
R
I
----------
L
E
F
--
N
K
--
R
N
I
T
A
-----
I
I
A
E
Y
K
R
K
S
P
S
--
G
L
D
V
E
R
D
P
I
E
Y
S
K
-
F
M
E
R
Y
A
V
G
L
S
I
L
T
E
E
K
Y
F
N
G
S
Y
E
T
L
R
K
I
A
S
S
V
S
I
P
I
L
M
K
D
F
I
V
K
E
S
Q
I
D
D
A
Y
N
L
G
A
D
T
V
L
L
I
V
K
I
L
T
E
R
E
L
E
S
L
L
-
E
Y
A
R
S
Y
G
M
E
P
L
I
E
I
N
D
E
N
D
L
D
-
I
A
L
R
I
G
A
R
F
I
G
I
N
S
R
D
L
E
T
L
E
I
N
K
E
N
Q
R
K
L
I
S
M
I
P
---
S
---
N
V
V
K
V
A
E
S
G
I
S
E
R
N
E
I
E
E
L
R
K
L
G---
V
N
A
-
F
L
I
G
S
S
L
M
R
N
P
---
E
K
I
K
E
F
-----
23
PsiBlast_CBE
79.22
37%
-36
- C6 -
-
1VC4
4
?
B:
[12-252]
-----
L
G
E
I
A
R
K
R
A
S
E
V
A
P
Y
P
L
P
E
--
P
P
S
--
V
P
S
F
K
E
----------
A
L
L
------
R
P
G
L
S
-----
V
I
A
E
V
K
R
Q
S
P
S
E
G
L
I
R
-
E
V
D
P
V
E
A
A
L
A
Y
A
R
G
G
A
R
A
V
S
V
L
T
E
P
H
R
F
G
G
S
L
L
D
L
K
R
V
R
E
A
V
D
L
P
L
L
R
K
D
F
V
V
D
P
F
M
L
E
E
A
R
A
F
G
A
S
A
A
L
L
I
V
A
L
L
G
E
--
L
T
G
A
Y
L
E
E
A
R
R
L
G
L
E
A
L
V
E
V
H
T
E
R
E
L
E
-
I
A
L
E
A
G
A
E
V
L
G
I
N
N
R
D
L
A
T
L
H
I
N
L
E
T
A
P
R
L
G
R
L
A
R
---
K
RGF
G
G
V
L
V
A
E
S
G
Y
S
R
K
E
E
L
K
A
L
E
G
L
----
F
D
A
-
V
L
I
G
T
S
L
M
R
A
P
D
L
E
A
A
L
R
E
L
-----
14
PsiBlast_PDB
78.93
36%
-113
- C6 -
-
1LBL
1
TRPC_SULSO
A:
[35-245]
-----------------------------------
R
I
----------
L
E
F
--
N
K
--
R
N
I
T
A
-----
I
I
A
E
Y
K
R
K
S
P
S
--
G
L
D
V
E
R
D
P
I
E
Y
S
K
-
F
M
E
R
Y
A
V
G
L
S
I
L
T
E
E
K
Y
F
N
G
S
Y
E
T
L
R
K
I
A
S
S
V
S
I
P
I
L
M
K
D
F
I
V
K
E
S
Q
I
D
D
A
Y
N
L
G
A
D
T
V
L
L
I
V
K
I
L
T
E
R
E
L
E
S
L
L
-
E
Y
A
R
S
Y
G
M
E
P
L
I
E
I
N
D
E
N
D
L
D
-
I
A
L
R
I
G
A
R
F
I
G
I
N
S
R
D
L
E
T
L
E
I
N
K
E
N
Q
R
K
L
I
S
M
I
P
---
S
---
N
V
V
K
V
A
E
S
G
I
S
E
R
N
E
I
E
E
L
R
K
L
G---
V
N
A
-
F
L
I
G
S
S
L
M
R
N
P
---
E
K
I
K
E
F
-----
10
PsiBlast_PDB
78.77
36%
-111
- C6 -
-
1IGS
-
TRPC_SULSO
A:
[36-246]
-----------------------------------
R
I
----------
L
E
F
--
N
K
--
R
N
I
T
A
-----
I
I
A
E
Y
K
R
K
S
P
S
--
G
L
D
V
E
R
D
P
I
E
Y
S
K
-
F
M
E
R
Y
A
V
G
L
S
I
L
T
E
E
K
Y
F
N
G
S
Y
E
T
L
R
K
I
A
S
S
V
S
I
P
I
L
M
K
D
F
I
V
K
E
S
Q
I
D
D
A
Y
N
L
G
A
D
T
V
L
L
I
V
K
I
L
T
E
R
E
L
E
S
L
L
-
E
Y
A
R
S
Y
G
M
E
P
L
I
E
I
N
D
E
N
D
L
D
-
I
A
L
R
I
G
A
R
F
I
G
I
N
S
R
D
L
E
T
L
E
I
N
K
E
N
Q
R
K
L
I
S
M
I
P
---
S
---
N
V
V
K
V
A
E
S
G
I
S
E
R
N
E
I
E
E
L
R
K
L
G---
V
N
A
-
F
L
I
G
S
S
L
M
R
N
P
---
E
K
I
K
E
F
-----
19
PsiBlast_PDB
78.60
34%
-122
- C6 -
-
4IX0
-
TRPC_SULSO
A:
[35-245]
-----------------------------------
R
I
----------
L
E
F
--
N
K
--
R
N
I
T
A
-----
I
I
A
E
Y
K
R
K
S
P
S
--
G
L
D
V
E
R
D
P
I
E
Y
A
K
-
F
M
E
R
Y
A
V
G
L
S
I
L
T
E
E
K
Y
F
N
G
S
Y
E
T
L
R
K
I
A
S
S
V
S
I
P
I
L
M
M
D
F
I
V
K
E
S
Q
I
D
D
A
Y
N
L
G
A
D
T
V
L
L
-
V
K
I
L
T
E
R
E
L
E
S
L
L
-
E
Y
A
R
S
Y
G
M
E
P
L
I
E
I
T
D
E
N
D
L
D
-
I
A
L
R
I
G
A
R
F
I
G
I
S
S
Q
D
D
E
T
L
E
I
N
K
E
N
Q
R
K
L
I
S
M
I
P
---
S
---
N
V
V
K
V
A
D
S
G
I
S
E
R
N
E
I
E
E
L
R
K
L
G---
V
N
A
-
F
L
I
G
S
S
L
M
R
N
P
---
E
K
I
K
E
L
-----
9
PsiBlast_PDB
78.45
37%
-108
- C6 -
-
3T78
1
TRPC_MYCTU
A:
[52-258]
-----------------------------------------------------------
I
G
-----
V
I
A
E
V
K
R
A
S
P
S
A
G
A
L
A
T
I
A
D
P
A
K
L
A
Q
A
Y
Q
D
G
G
A
R
I
V
S
V
V
T
E
Q
R
R
F
Q
G
S
L
D
D
L
D
A
V
R
A
S
V
S
I
P
V
L
R
K
D
F
V
V
Q
P
Y
Q
I
H
E
A
R
A
H
G
A
D
M
L
L
L
I
V
A
A
L
E
Q
S
V
L
V
S
M
L
-
D
R
T
E
S
L
G
M
T
A
L
V
E
V
H
T
E
Q
E
A
D
-
R
A
L
K
A
G
A
K
V
I
G
V
N
A
R
D
L
M
T
L
--
D
R
D
C
F
A
R
I
A
P
G
L
P
---
S
---
S
V
I
R
I
A
E
S
G
V
R
G
T
A
D
---
L
L
A
Y
A
G
A
G
A
D
A
-
V
L
V
G
E
G
L
V
T
S
G
D
P
R
A
A
V
A
D
L
-----
8
PsiBlast_PDB
78.38
37%
-109
- C6 -
-
3T55
1
TRPC_MYCTU
A:
[52-258]
-----------------------------------------------------------
I
G
-----
V
I
A
E
V
K
R
A
S
P
S
A
G
A
L
A
T
I
A
D
P
A
K
L
A
Q
A
Y
Q
D
G
G
A
R
I
V
S
V
V
T
E
Q
R
R
F
Q
G
S
L
D
D
L
D
A
V
R
A
S
V
S
I
P
V
L
R
K
D
F
V
V
Q
P
Y
Q
I
H
E
A
R
A
H
G
A
D
M
L
L
L
I
V
A
A
L
E
Q
S
V
L
V
S
M
L
-
D
R
T
E
S
L
G
M
T
A
L
V
E
V
H
T
E
Q
E
A
D
-
R
A
L
K
A
G
A
K
V
I
G
V
N
A
R
D
L
M
T
L
D
V
D
R
D
C
F
A
R
I
A
P
G
L
P
---
S
---
S
V
I
R
I
A
E
S
G
V
R
G
T
A
D
---
L
L
A
Y
A
G
A
G
A
D
A
-
V
L
V
G
E
G
L
V
T
S
G
D
P
R
A
A
V
A
D
L
-----
12
PsiBlast_PDB
78.35
36%
-109
- C6 -
-
1JUL
1
TRPC_SULSO
A:
[36-246]
-----------------------------------
R
I
----------
L
E
F
--
N
K
--
R
N
I
T
A
-----
I
I
A
E
Y
K
R
K
S
P
S
--
G
L
D
V
E
R
D
P
I
E
Y
S
K
-
F
M
E
R
Y
A
V
G
L
S
I
L
T
E
E
K
Y
F
N
G
S
Y
E
T
L
R
K
I
A
S
S
V
S
I
P
I
L
M
K
D
F
I
V
K
E
S
Q
I
D
D
A
Y
N
L
G
A
D
T
V
L
L
I
V
K
I
L
T
E
R
E
L
E
S
L
L
-
E
Y
A
R
S
Y
G
M
E
P
L
I
E
I
N
D
E
N
D
L
D
-
I
A
L
R
I
G
A
R
F
I
G
I
N
S
R
D
L
E
T
L
E
I
N
K
E
N
Q
R
K
L
I
S
M
I
P
---
S
---
N
V
V
K
V
A
E
S
G
I
S
E
R
N
E
I
E
E
L
R
K
L
G---
V
N
A
-
F
L
I
G
S
S
L
M
R
N
P
---
E
K
I
K
E
F
-----
65
HHSearch
78.21
37%
-2
- C6 -
-
1JCM
1
TRPC_ECOLI
P:
[1-254]
-
M
Q
C
V
L
A
K
I
V
A
D
K
A
I
W
V
E
A
R
--
K
Q
Q
-
Q
P
L
--
A
S
F
Q
N
E
VQPSTRHF--
Y
D
A
L
Q
----
G
A
R
T
A
-----
F
I
L
E
C
K
K
A
S
P
S
K
G
V
I
R
D
D
F
D
P
A
R
I
A
A
I
Y
K
-
H
Y
A
S
A
I
S
V
L
T
D
E
K
Y
F
Q
G
S
F
N
F
L
P
I
V
S
Q
I
A
P
Q
P
I
L
C
K
D
F
I
I
D
P
Y
Q
I
Y
L
A
R
Y
Y
Q
A
D
A
C
L
L
M
L
S
V
L
D
D
D
Q
Y
R
Q
L
A
-
A
V
A
H
S
L
E
M
G
V
L
T
E
V
S
N
E
E
E
Q
E
-
R
A
I
A
L
G
A
K
V
V
G
I
N
N
R
D
L
C
D
L
S
I
D
L
N
R
T
R
E
L
A
P
K
L
G
---
H
---
N
V
T
V
I
S
E
S
G
I
N
T
Y
A
Q
V
R
E
L
S
H
F
----
A
N
G
-
F
L
I
G
S
A
L
M
A
H
D
D
L
H
A
A
V
R
R
V
L
L
---
4
PsiBlast_PDB
77.96
37%
-39
- C6 -
-
1VC4
1
?
A:
[12-252]
-----
L
G
E
I
A
R
K
R
A
S
E
V
A
P
Y
P
L
P
E
--
P
P
S
--
V
P
S
F
K
E
----------
A
L
L
------
R
P
G
L
S
-----
V
I
A
E
V
K
R
Q
S
P
S
E
G
L
I
R
-
E
V
D
P
V
E
A
A
L
A
Y
A
R
G
G
A
R
A
V
S
V
L
T
E
P
H
R
F
G
G
S
L
L
D
L
K
R
V
R
E
A
V
D
L
P
L
L
R
K
D
F
V
V
D
P
F
M
L
E
E
A
R
A
F
G
A
S
A
A
L
L
I
V
A
L
L
G
E
--
L
T
G
A
Y
L
E
E
A
R
R
L
G
L
E
A
L
V
E
V
H
T
E
R
E
L
E
-
I
A
L
E
A
G
A
E
V
L
G
I
N
N
R
D
L
A
T
L
H
I
N
L
E
T
A
P
R
L
G
R
L
A
R
---
K
R
GF
G
G
V
L
V
A
E
S
G
Y
S
R
K
E
E
L
K
A
L
E
G
L
----
F
D
A
-
V
L
I
G
T
S
L
M
R
A
P
D
L
E
A
A
L
R
E
L
-----
17
PsiBlast_PDB
77.78
37%
-117
- C6 -
-
4FB7
1
TRPC_MYCTU
A:
[55-261]
-----------------------------------------------------------
I
G
-----
V
I
A
E
V
K
R
A
S
P
S
A
G
A
L
A
T
I
A
D
P
A
K
L
A
Q
A
Y
Q
D
G
G
A
R
I
V
S
V
V
T
E
Q
R
R
F
Q
G
S
L
D
D
L
D
A
V
R
A
S
V
S
I
P
V
L
R
K
D
F
V
V
Q
P
Y
Q
I
H
E
A
R
A
H
G
A
D
M
L
L
L
I
V
A
A
L
E
Q
S
V
L
V
S
M
L
-
D
R
T
E
S
L
G
M
T
A
L
V
E
V
H
T
E
Q
E
A
D
-
R
A
L
K
A
G
A
K
V
I
G
V
N
A
R
D
L
M
T
L
D
V
D
R
D
C
F
A
R
I
A
P
G
L
P
---
S
---
S
V
I
R
I
A
E
S
G
V
R
G
T
A
D
---
L
L
A
Y
A
G
A
G
A
D
A
-
V
L
V
G
E
G
L
V
T
S
G
D
P
R
A
A
V
A
D
L
-----
32
PsiBlast_CBE
77.47
33%
-127
- C6 -
-
3UXD
1
?
A:
[36-246]
-----------------------------------
R
I
----------
L
E
F
--
N
K
--
R
N
I
T
A
-----
I
I
A
V
Y
K
R
K
S
P
S
--
G
L
D
V
E
R
D
P
I
E
Y
A
K
-
F
M
E
R
Y
A
V
G
L
V
I
L
T
E
E
K
Y
F
N
G
S
Y
E
D
L
R
K
I
A
S
S
V
S
I
P
I
L
M
W
D
F
I
V
K
E
S
Q
I
D
D
A
Y
N
L
G
A
D
T
V
G
L
I
V
K
I
L
T
E
R
E
L
E
S
L
L
-
E
Y
A
R
S
Y
G
M
E
P
A
I
V
I
N
D
E
E
D
L
D
-
I
A
L
R
I
G
A
R
I
I
I
I
S
S
R
D
L
E
T
L
E
I
N
K
E
N
Q
R
K
L
I
S
M
I
P
---
S
---
N
V
V
K
V
A
A
S
G
I
S
E
R
N
E
I
E
E
L
R
K
L
G---
V
N
A
-
F
E
I
G
S
S
L
M
R
N
P
---
E
K
I
K
E
L
-----
63
HHSearch
77.24
38%
6
- C6 -
-
1PII
-
TRPC_ECOLI
A:
[1-254]
-
M
Q
T
V
L
A
K
I
V
A
D
K
A
I
W
V
E
A
R
--
K
Q
Q
-
Q
P
L
--
A
S
F
Q
N
E
VQPSTRH
F
--
Y
D
A
L
Q
----
G
A
R
T
A
-----
F
I
L
E
C
K
K
A
S
P
S
K
G
V
I
R
D
D
F
D
P
A
R
I
A
A
I
Y
K
-
H
Y
A
S
A
I
S
V
L
T
D
E
K
Y
F
Q
G
S
F
N
F
L
P
I
V
S
Q
I
A
P
Q
P
I
L
C
K
D
F
I
I
D
P
Y
Q
I
Y
L
A
R
Y
Y
Q
A
D
A
C
L
L
M
L
S
V
L
D
D
D
Q
Y
R
Q
L
A
-
A
V
A
H
S
L
E
M
G
V
L
T
E
V
S
N
E
E
E
Q
E
-
R
A
I
A
L
G
A
K
V
V
G
I
N
N
R
D
L
R
D
L
S
I
D
L
N
R
T
R
E
L
A
P
K
L
G
---
H
---
N
V
T
V
I
S
E
S
G
I
N
T
Y
A
Q
V
R
E
L
S
-
H
F---
A
N
G
-
F
L
I
G
S
A
L
M
A
H
D
D
L
H
A
A
V
R
R
V
L
L
---
18
PsiBlast_PDB
77.20
34%
-117
- C6 -
-
4IWW
-
TRPC_SULSO
A:
[35-245]
-----------------------------------
R
I
----------
L
E
F
--
N
K
--
R
N
I
T
A
-----
I
I
A
E
Y
K
R
K
S
P
S
--
G
L
D
V
E
R
D
P
I
E
Y
A
K
-
F
M
E
R
Y
A
V
G
L
S
I
L
T
E
E
K
Y
F
N
G
S
Y
E
T
L
R
K
I
A
S
S
V
S
I
P
I
L
M
M
D
F
I
V
K
E
S
Q
I
D
D
A
Y
N
L
G
A
D
T
V
L
L
-
V
K
I
L
T
E
R
E
L
E
S
L
L
-
E
Y
A
R
S
Y
G
M
E
P
L
I
E
I
T
D
E
N
D
L
D
-
I
A
L
R
I
G
A
R
F
I
G
I
S
S
Q
D
D
E
T
L
E
I
N
K
E
N
Q
R
K
L
I
S
M
I
P
---
S
---
N
V
V
K
V
A
D
S
G
I
S
E
R
N
E
I
E
E
L
R
K
L
G---
V
N
A
-
F
L
I
G
S
S
L
M
R
N
P
---
E
K
I
K
E
L
-----
35
PsiBlast_CBE
77.14
31%
-140
- C6 -
-
3UZJ
1
?
B:
[36-246]
-----------------------------------
R
I
----------
L
E
F
--
N
K
--
R
N
I
T
A
-----
I
M
A
V
Y
K
R
K
S
P
S
--
G
L
D
V
E
R
D
P
I
E
Y
A
K
-
F
M
E
R
G
V
V
G
L
A
I
L
T
E
E
K
Y
F
N
G
S
Y
E
D
L
R
K
I
A
S
S
V
S
V
P
I
L
M
W
D
I
I
V
K
E
S
Q
I
D
D
A
Y
N
L
G
A
D
T
V
G
L
I
V
K
I
L
T
E
R
E
L
E
S
L
L
-
E
Y
A
R
S
L
G
M
E
P
A
I
V
I
H
D
E
N
D
L
D
-
I
A
L
R
I
G
A
R
F
I
I
I
T
S
H
D
-----
I
N
N
E
N
Q
R
K
L
I
S
M
I
P
---
S
---
N
V
V
K
V
V
A
S
G
I
S
E
R
N
E
I
E
E
L
Y
K
L
G---
V
N
A
-
F
E
I
G
T
S
L
M
R
N
P
---
E
K
I
K
E
F
-----
11
PsiBlast_PDB
77.09
36%
-107
- C6 -
-
1JUK
-
TRPC_SULSO
A:
[36-246]
-----------------------------------
R
I
----------
L
E
F
--
N
K
--
R
N
I
T
A
-----
I
I
A
E
Y
K
R
K
S
P
S
--
G
L
D
V
E
R
D
P
I
E
Y
S
K
-
F
M
E
R
Y
A
V
G
L
S
I
L
T
E
E
K
Y
F
N
G
S
Y
E
T
L
R
K
I
A
S
S
V
S
I
P
I
L
M
K
D
F
I
V
K
E
S
Q
I
D
D
A
Y
N
L
G
A
D
T
V
L
L
I
V
K
I
L
T
E
R
E
L
E
S
L
L
-
E
Y
A
R
S
Y
G
M
E
P
L
I
E
I
N
D
E
N
D
L
D
-
I
A
L
R
I
G
A
R
F
I
G
I
N
S
R
D
L
E
T
L
E
I
N
K
E
N
Q
R
K
L
I
S
M
I
P
---
S
---
N
V
V
K
V
A
E
S
G
I
S
E
R
N
E
I
E
E
L
R
K
L
G---
V
N
A
-
F
L
I
G
S
S
L
M
R
N
P
---
E
K
I
K
E
F
-----
7
PsiBlast_PDB
77.07
37%
-104
- C6 -
-
3T44
2
TRPC_MYCTU
A:
[52-258]
-----------------------------------------------------------
I
G
-----
V
I
A
E
V
K
R
A
S
P
S
A
G
A
L
A
T
I
A
D
P
A
K
L
A
Q
A
Y
Q
D
G
G
A
R
I
V
S
V
V
T
E
Q
R
R
F
Q
G
S
L
D
D
L
D
A
V
R
A
S
V
S
I
P
V
L
R
K
D
F
V
V
Q
P
Y
Q
I
H
E
A
R
A
H
G
A
D
M
L
L
L
I
V
A
A
L
E
Q
S
V
L
V
S
M
L
-
D
R
T
E
S
L
G
M
T
A
L
V
E
V
H
T
E
Q
E
A
D
-
R
A
L
K
A
G
A
K
V
I
G
V
N
A
R
D
L
M
T
L
D
V
D
R
D
C
F
A
R
I
A
P
G
L
P
---
S
---
S
V
I
R
I
A
E
S
G
V
R
G
T
A
D
---
L
L
A
Y
A
G
A
G
A
D
A
-
V
L
V
G
E
G
L
V
T
S
G
D
P
R
A
A
V
A
D
L
-----
61
HHSearch
75.90
38%
-2
- C6 -
-
3TSM
4
TRPC_BRUA2
B:
[9-267]
----
I
L
R
K
I
E
A
Y
K
R
E
E
I
A
A
A
--
K
A
R
-
L
A
L
--
D
E
L
K
A
R
T
R
D
QSAPRG
F
L
K
A
L
E
A
K
R
A
A
G
Q
F
A
-----
L
I
A
E
I
K
K
A
S
P
S
K
G
L
I
R
P
D
F
D
P
P
A
L
A
K
A
Y
E
E
G
G
A
A
C
L
S
V
L
T
D
T
P
S
F
Q
G
A
P
E
F
L
T
A
A
R
Q
A
C
S
L
P
A
L
R
K
D
F
L
F
D
P
Y
Q
V
Y
E
A
R
S
W
G
A
D
C
I
L
I
I
M
A
S
V
D
D
D
L
A
K
E
L
E
-
D
T
A
F
A
L
G
M
D
A
L
I
E
V
H
D
E
A
E
M
E
-
R
A
L
K
L
S
S
R
L
L
G
V
N
N
R
N
L
R
S
F
E
V
N
L
A
V
S
E
R
L
A
K
M
A
P
---
S
---
D
R
L
L
V
G
E
S
G
I
F
T
H
E
D
C
L
R
L
E
K
S
G---
I
G
T
-
F
L
I
G
E
S
L
M
R
Q
H
D
V
A
A
A
T
R
A
L
L
T
---
64
HHSearch
74.75
38%
32
- C6 -
-
1VC4
4
?
B:
[8-253]
-
V
P
G
V
L
G
E
I
A
R
K
R
A
S
E
V
A
P
Y
--
P
L
P
-
E
P
P
SV
P
S
F
-------------
K
E
A
L
L
----
R
P
G
L
S
-----
V
I
A
E
V
K
R
Q
S
P
S
E
G
L
I
R
E
-
V
D
P
V
E
A
A
L
A
Y
A
R
G
G
A
R
A
V
S
V
L
T
E
P
H
R
F
G
G
S
L
L
D
L
K
R
V
R
E
A
V
D
L
P
L
L
R
K
D
F
V
V
D
P
F
M
L
E
E
A
R
A
F
G
A
S
A
A
L
L
I
V
A
L
L
G
-
E
L
T
G
A
Y
L
-
E
E
A
R
R
L
G
L
E
A
L
V
E
V
H
T
E
R
E
L
E
-
I
A
L
E
A
G
A
E
V
L
G
I
N
N
R
D
L
A
T
L
H
I
N
L
E
T
A
P
R
L
G
R
L
A
R
KRG
F
---
G
G
V
L
V
A
E
S
G
Y
S
R
K
E
E
L
K
A
L
E
-
G
L---
F
D
A
-
V
L
I
G
T
S
L
M
R
A
P
D
L
E
A
A
L
R
E
L
V
----
5
PsiBlast_PDB
74.60
38%
-0
- C6 -
-
1JCM
1
TRPC_ECOLI
P:
[2-245]
--
Q
C
V
L
A
K
I
V
A
D
K
A
I
W
V
E
A
R
K
--
Q
Q
-
Q
P
L
--
A
S
F
Q
N
E
----------
V
Q
P
S
T
R
H
F-
Y
D
A
L
Q
GARTA
F
I
L
E
C
K
K
A
S
P
S
K
G
V
I
R
D
D
F
D
P
A
R
I
A
A
I
Y
K
H
Y
-
A
S
A
I
S
V
L
T
D
E
K
Y
F
Q
G
S
F
N
F
L
P
I
V
S
Q
I
A
P
Q
P
I
L
C
K
D
F
I
I
D
P
Y
Q
I
Y
L
A
R
Y
Y
Q
A
D
A
C
L
L
M
L
S
V
L
D
D
D
Q
Y
R
Q
L
A
-
A
V
A
H
S
L
E
M
G
V
L
T
E
V
S
N
E
E
E
Q
E
-
R
A
I
A
L
G
A
K
V
V
G
I
N
N
R
D
L
C
D
L
S
I
D
L
N
R
T
R
E
L
A
P
K
L
G
---
H
---
N
V
T
V
I
S
E
S
G
I
N
T
Y
A
Q
V
R
E
L
S
H
F
----
A
N
G
-
F
L
I
G
S
A
L
M
A
H
D
D
L
------------
67
HHSearch
69.90
33%
16
- C6 -
-
1A53
1
TRPC_SULSO
A:
[5-244]
--
K
G
W
L
K
D
V
V
Q
L
S
L
R
R
P
S
F
R
--
A
S
R
Q
R
P
I
--
I
S
L
N
-------------
E
R
I
L
E
F
N
K
R
N
I
T
A
-----
I
I
A
E
Y
K
R
K
S
P
S
G
L
D
V
--
E
R
D
P
I
E
Y
S
K
F
M
E
R
-
Y
A
V
G
L
S
I
L
T
E
E
K
Y
F
N
G
S
Y
E
T
L
R
K
I
A
S
S
V
S
I
P
I
L
M
K
D
F
I
V
K
E
S
Q
I
D
D
A
Y
N
L
G
A
D
T
V
L
L
I
V
K
I
L
T
E
R
E
L
E
S
L
L
-
E
Y
A
R
S
Y
G
M
E
P
L
I
E
I
N
D
E
N
D
L
D
-
I
A
L
R
I
G
A
R
F
I
G
I
N
S
R
D
L
E
T
L
E
I
N
K
E
N
Q
R
K
L
I
S
M
I
P
---
S
---
N
V
V
K
V
A
E
S
G
I
S
E
R
N
E
I
E
E
L
R
K
L
G---
V
N
A
-
F
L
I
G
S
S
L
M
R
N
P
E
K
I
K
E
---------