@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : spr1647: (2018-01-16 )
MAILVTGGAGYIGSHTVVELLNLGKEVIIVDNLSNSSILVLDRIEAITGIRPVFYELDVCDKPALRKVFEQESIDAAIHFAGYKAVGESVQKPVMYYKNNIMSTLALVEVMSEFNVKKIVFSSSATVYGINNQSPLIETMQTSATNPYGYTKVMLEQILKDVHVADSEWSIALLRYFNPIGAHESGLIGEDPSGIPNNLMPYIAQVAVGKLSELSVFGNDYDTLDGTGVRDYIHVVDLAIGHIKALEKVSEKTDVYIYNLGSGEGTSVLQLVNTFESVNKIPIPYKIVPRRSGDVATCYANADKAYKELNWRTTKSIEDMCRDTWN
Atome Classification :
(47 SA)
-.........10........20........30...---.------.---.---..40........50........60........70.........80........90........100.......110.......120.......----130.......140.-..-.....150.......160....-------------..-.170.......180.......190.........200.......210.......220.......230.......240.......-250..----.....260.......270.......280.......290.......300.......310.......320....-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
-
M
A
I
L
V
TGGAGYI
G
S
H
T
V
V
E
L
L
NLGK
E
V
I
I
V
DNLS---N------
S
---
S
---
I
L
V
L
D
R
I
E
A
I
TGIR
P
V
F
Y
ELDVCD
K
P
A
L
R
K
V
F
E
-
Q
ESI
D
A
A
I
H
FA
G
Y
K
A
V
G
E
S
V
Q
K
P
V
M
Y
Y
K
N
N
I
M
S
T
L
A
L
V
E
V
M
S
EFN
V
K
K
I
V
FSSS
A
T
V
Y
G
----INNQ
S
P
L
I
E
T
M
Q
-T-SA-TNPY
G
Y
T
K
V
M
L
E
Q
I
L
K
DVHVAD-------------SE-
W
S
I
A
L
L
R
YFNPIGAHESGLIGE--DPSGIP
N
N
L
M
P
Y
I
A
Q
V
A
VGKL
S
E
L
S
V
FGNDYDTLDGT
G
V
R
D
Y
I
H
V
V
D
L
A
I
G
H
I
K
A
L
E
K
V-SEKT
D
----
V
Y
I
Y
NLGSGE
G
T
S
V
L
Q
L
V
N
T
F
E
S
V
NKIPI
P
Y
K
IVPRRSG
D
V
A
T
C
YA
N
A
D
K
A
Y
K
ELNWRT
T
K
S
I
E
D
M
C
R
DTWN-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
87
HHSearch
96.97
60%
-107
- C1 -
-
3ENK
2
?
A:
[6-331]
-
G
T
I
L
V
T
G
G
A
G
Y
I
G
S
H
T
A
V
E
L
L
A
H
G
Y
D
V
V
I
A
D
N
L
V
---
N
------
S
---
K
---
R
E
A
I
A
R
I
E
K
I
T
G
K
T
P
A
F
H
E
T
D
V
S
D
E
R
A
L
A
R
I
F
D
-
A
H
P
I
T
A
A
I
H
F
A
A
L
K
A
V
G
E
S
V
A
K
P
I
E
Y
Y
R
N
N
L
D
S
L
L
S
L
L
R
V
M
R
E
R
A
V
K
R
I
V
F
S
S
S
A
T
V
Y
G
----
V
P
E
R
S
P
I
D
E
T
F
P
-
L
-
S
A
-
T
N
P
Y
G
Q
T
K
L
M
A
E
Q
I
L
R
D
V
E
A
A
D
-------------
P
S
-
W
R
V
A
T
L
R
Y
F
N
P
V
G
A
H
E
S
G
L
I
G
E
--
D
P
A
G
I
P
N
N
L
M
P
Y
V
A
Q
V
A
V
G
K
L
E
K
L
R
V
F
G
S
D
Y
P
T
P
D
G
T
G
V
R
D
Y
I
H
V
V
D
L
A
R
G
H
I
A
A
L
D
A
L
-
E
R
R
D
A
----
S
L
T
V
N
L
G
T
G
R
G
Y
S
V
L
E
V
V
R
A
F
E
K
A
S
G
R
A
V
P
Y
E
L
V
A
R
R
P
G
D
V
A
E
C
Y
A
N
P
A
A
A
A
E
T
I
G
W
K
A
E
R
D
L
E
R
M
C
A
D
H
W
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
88
HHSearch
96.96
60%
-107
- C1 -
-
3ENK
2
?
B:
[6-331]
-
G
T
I
L
V
T
G
G
A
G
Y
I
G
S
H
T
A
V
E
L
L
A
H
G
Y
D
V
V
I
A
D
N
L
V
---
N
------
S
---
K
---
R
E
A
I
A
R
I
E
K
I
T
G
K
T
P
A
F
H
E
T
D
V
S
D
E
R
A
L
A
R
I
F
D
-
A
H
P
I
T
A
A
I
H
F
A
A
L
K
A
V
G
E
S
V
A
K
P
I
E
Y
Y
R
N
N
L
D
S
L
L
S
L
L
R
V
M
R
E
R
A
V
K
R
I
V
F
S
S
S
A
T
V
Y
G
----
V
P
E
R
S
P
I
D
E
T
F
P
-
L
-
S
A
-
T
N
P
Y
G
Q
T
K
L
M
A
E
Q
I
L
R
D
V
E
A
A
D
-------------
P
S
-
W
R
V
A
T
L
R
Y
F
N
P
V
G
A
H
E
S
G
L
I
G
E
--
D
P
A
G
I
P
N
N
L
M
P
Y
V
A
Q
V
A
V
G
K
L
E
K
L
R
V
F
G
S
D
Y
P
T
P
D
G
T
G
V
R
D
Y
I
H
V
V
D
L
A
R
G
H
I
A
A
L
D
A
L
-
E
R
R
D
A
----
S
L
T
V
N
L
G
T
G
R
G
Y
S
V
L
E
V
V
R
A
F
E
K
A
S
G
R
A
V
P
Y
E
L
V
A
R
R
P
G
D
V
A
E
C
Y
A
N
P
A
A
A
A
E
T
I
G
W
K
A
E
R
D
L
E
R
M
C
A
D
H
W
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
PsiBlast_CBE
95.86
60%
-108
- C1 -
-
3ENK
2
?
B:
[8-331]
---
I
L
V
T
G
G
A
G
Y
I
G
S
H
T
A
V
E
L
L
A
H
G
Y
D
V
V
I
A
D
N
L
V
---
N
------
S
---
K
---
R
E
A
I
A
R
I
E
K
I
T
G
K
T
P
A
F
H
E
T
D
V
S
D
E
R
A
L
A
R
I
F
D
-
A
H
P
I
T
A
A
I
H
F
A
A
L
K
A
V
G
E
S
V
A
K
P
I
E
Y
Y
R
N
N
L
D
S
L
L
S
L
L
R
V
M
R
E
R
A
V
K
R
I
V
F
S
S
S
A
T
V
Y
G
----
V
P
E
R
S
P
I
D
E
T
F
P
-
L
-
S
A
-
T
N
P
Y
G
Q
T
K
L
M
A
E
Q
I
L
R
D
V
E
A
A
D
-------------
P
S
-
W
R
V
A
T
L
R
Y
F
N
P
V
G
A
H
E
S
G
L
I
G
E
--
D
P
A
G
I
P
N
N
L
M
P
Y
V
A
Q
V
A
V
G
K
L
E
K
L
R
V
F
G
S
D
Y
P
T
P
D
G
T
G
V
R
D
Y
I
H
V
V
D
L
A
R
G
H
I
A
A
L
D
A
L
-
E
R
R
D
A
----
S
L
T
V
N
L
G
T
G
R
G
Y
S
V
L
E
V
V
R
A
F
E
K
A
S
G
R
A
V
P
Y
E
L
V
A
R
R
P
G
D
V
A
E
C
Y
A
N
P
A
A
A
A
E
T
I
G
W
K
A
E
R
D
L
E
R
M
C
A
D
H
W
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
95.60
60%
-108
- C1 -
-
3ENK
2
?
A:
[8-331]
---
I
L
V
T
G
G
A
G
Y
I
G
S
H
T
A
V
E
L
L
A
H
G
Y
D
V
V
I
A
D
N
L
V
---
N
------
S
---
K
---
R
E
A
I
A
R
I
E
K
I
T
G
K
T
P
A
F
H
E
T
D
V
S
D
E
R
A
L
A
R
I
F
D
-
A
H
P
I
T
A
A
I
H
F
A
A
L
K
A
V
G
E
S
V
A
K
P
I
E
Y
Y
R
N
N
L
D
S
L
L
S
L
L
R
V
M
R
E
R
A
V
K
R
I
V
F
S
S
S
A
T
V
Y
G
----
V
P
E
R
S
P
I
D
E
T
F
P
-
L
-
S
A
-
T
N
P
Y
G
Q
T
K
L
M
A
E
Q
I
L
R
D
V
E
A
A
D
-------------
P
S
-
W
R
V
A
T
L
R
Y
F
N
P
V
G
A
H
E
S
G
L
I
G
E
--
D
P
A
G
I
P
N
N
L
M
P
Y
V
A
Q
V
A
V
G
K
L
E
K
L
R
V
F
G
S
D
Y
P
T
P
D
G
T
G
V
R
D
Y
I
H
V
V
D
L
A
R
G
H
I
A
A
L
D
A
L
-
E
R
R
D
A
----
S
L
T
V
N
L
G
T
G
R
G
Y
S
V
L
E
V
V
R
A
F
E
K
A
S
G
R
A
V
P
Y
E
L
V
A
R
R
P
G
D
V
A
E
C
Y
A
N
P
A
A
A
A
E
T
I
G
W
K
A
E
R
D
L
E
R
M
C
A
D
H
W
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
89.20
55%
-56
- C1 -
-
1KVQ
3
GALE_ECOLI
A:
[1-327]
-
M
R
V
L
V
T
G
G
S
G
Y
I
G
S
H
T
C
V
Q
L
L
Q
N
G
H
D
V
I
I
L
D
N
L
C
---
N
------
S
---
K
---
R
S
V
L
P
V
I
E
R
L
G
G
K
H
P
T
F
V
E
G
D
I
R
N
E
A
L
M
T
E
I
L
H
-
D
H
A
I
D
T
V
I
H
F
A
G
L
K
A
V
G
E
S
V
Q
K
P
L
E
Y
Y
D
N
N
V
N
G
T
L
R
L
I
S
A
M
R
A
A
N
V
K
N
F
I
F
S
S
A
A
T
V
Y
G
----
D
N
P
K
I
P
Y
V
E
S
F
P
-
T
G
T
P
-
Q
S
P
Y
G
K
S
K
L
M
V
E
Q
I
L
T
D
L
Q
K
A
Q
-------------
P
D
-
W
S
I
A
L
L
R
Y
F
N
P
V
G
A
H
P
S
G
D
M
G
E
--
D
P
Q
G
I
P
N
N
L
M
P
Y
I
A
Q
V
A
V
G
R
R
D
S
L
A
I
F
G
N
D
Y
P
T
E
D
G
T
G
V
R
D
Y
I
H
V
M
D
L
A
D
G
H
V
V
A
M
E
K
L
-
A
N
K
P
G
----
V
H
I
Y
N
L
G
A
G
V
G
N
S
V
L
D
V
V
N
A
F
S
K
A
C
G
K
P
V
N
Y
H
F
A
P
R
R
E
G
D
L
P
A
Y
W
A
D
A
S
K
A
D
R
E
L
N
W
R
V
T
R
T
L
D
E
M
A
Q
D
T
W
H
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
88.74
56%
-58
- C1 -
-
1LRK
3
GALE_ECOLI
A:
[1-327]
-
M
R
V
L
V
T
G
G
S
G
Y
I
G
S
H
T
C
V
Q
L
L
Q
N
G
H
D
V
I
I
L
D
N
L
C
---
N
------
S
---
K
---
R
S
V
L
P
V
I
E
R
L
G
G
K
H
P
T
F
V
E
G
D
I
R
N
E
A
L
M
T
E
I
L
H
-
D
H
A
I
D
T
V
I
H
F
A
G
L
K
A
V
G
E
S
V
Q
K
P
L
E
Y
Y
D
N
N
V
N
G
T
L
R
L
I
S
A
M
R
A
A
N
V
K
N
F
I
F
S
S
S
A
T
V
Y
G
----
D
N
P
K
I
P
Y
V
E
S
F
P
-
T
G
T
P
-
Q
S
P
Y
G
K
S
K
L
M
V
E
Q
I
L
T
D
L
Q
K
A
Q
-------------
P
D
-
W
S
I
A
L
L
R
Y
F
N
P
V
G
A
H
P
S
G
D
M
G
E
--
D
P
Q
G
I
P
N
N
L
M
P
Y
I
A
Q
V
A
V
G
R
R
D
S
L
A
I
F
G
N
D
Y
P
T
E
D
G
T
G
V
R
D
Y
I
H
V
M
D
L
A
D
G
H
V
V
A
M
E
K
L
-
A
N
K
P
G
----
V
H
I
Y
N
L
G
A
G
V
G
N
S
V
L
D
V
V
N
A
F
S
K
A
C
G
K
P
V
N
Y
H
F
A
P
R
R
E
G
D
L
P
A
C
W
A
D
A
S
K
A
D
R
E
L
N
W
R
V
T
R
T
L
D
E
M
A
Q
D
T
W
H
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
88.32
56%
-55
- C1 -
-
1LRJ
3
GALE_ECOLI
A:
[1-327]
-
M
R
V
L
V
T
G
G
S
G
Y
I
G
S
H
T
C
V
Q
L
L
Q
N
G
H
D
V
I
I
L
D
N
L
C
---
N
------
S
---
K
---
R
S
V
L
P
V
I
E
R
L
G
G
K
H
P
T
F
V
E
G
D
I
R
N
E
A
L
M
T
E
I
L
H
-
D
H
A
I
D
T
V
I
H
F
A
G
L
K
A
V
G
E
S
V
Q
K
P
L
E
Y
Y
D
N
N
V
N
G
T
L
R
L
I
S
A
M
R
A
A
N
V
K
N
F
I
F
S
S
S
A
T
V
Y
G
----
D
N
P
K
I
P
Y
V
E
S
F
P
-
T
G
T
P
-
Q
S
P
Y
G
K
S
K
L
M
V
E
Q
I
L
T
D
L
Q
K
A
Q
-------------
P
D
-
W
S
I
A
L
L
R
Y
F
N
P
V
G
A
H
P
S
G
D
M
G
E
--
D
P
Q
G
I
P
N
N
L
M
P
Y
I
A
Q
V
A
V
G
R
R
D
S
L
A
I
F
G
N
D
Y
P
T
E
D
G
T
G
V
R
D
Y
I
H
V
M
D
L
A
D
G
H
V
V
A
M
E
K
L
-
A
N
K
P
G
----
V
H
I
Y
N
L
G
A
G
V
G
N
S
V
L
D
V
V
N
A
F
S
K
A
C
G
K
P
V
N
Y
H
F
A
P
R
R
E
G
D
L
P
A
Y
W
A
D
A
S
K
A
D
R
E
L
N
W
R
V
T
R
T
L
D
E
M
A
Q
D
T
W
H
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
88.30
56%
-53
- C1 -
-
1UDB
4
GALE_ECOLI
A:
[1-327]
-
M
R
V
L
V
T
G
G
S
G
Y
I
G
S
H
T
C
V
Q
L
L
Q
N
G
H
D
V
I
I
L
D
N
L
C
---
N
------
S
---
K
---
R
S
V
L
P
V
I
E
R
L
G
G
K
H
P
T
F
V
E
G
D
I
R
N
E
A
L
M
T
E
I
L
H
-
D
H
A
I
D
T
V
I
H
F
A
G
L
K
A
V
G
E
S
V
Q
K
P
L
E
Y
Y
D
N
N
V
N
G
T
L
R
L
I
S
A
M
R
A
A
N
V
K
N
F
I
F
S
S
S
A
T
V
Y
G
----
D
N
P
K
I
P
Y
V
E
S
F
P
-
T
G
T
P
-
Q
S
P
Y
G
K
S
K
L
M
V
E
Q
I
L
T
D
L
Q
K
A
Q
-------------
P
D
-
W
S
I
A
L
L
R
Y
F
N
P
V
G
A
H
P
S
G
D
M
G
E
--
D
P
Q
G
I
P
N
N
L
M
P
Y
I
A
Q
V
A
V
G
R
R
D
S
L
A
I
F
G
N
D
Y
P
T
E
D
G
T
G
V
R
D
Y
I
H
V
M
D
L
A
D
G
H
V
V
A
M
E
K
L
-
A
N
K
P
G
----
V
H
I
Y
N
L
G
A
G
V
G
N
S
V
L
D
V
V
N
A
F
S
K
A
C
G
K
P
V
N
Y
H
F
A
P
R
R
E
G
D
L
P
A
Y
W
A
D
A
S
K
A
D
R
E
L
N
W
R
V
T
R
T
L
D
E
M
A
Q
D
T
W
H
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
88.07
56%
-57
- C1 -
-
1NAI
4
GALE_ECOLI
A:
[1-327]
-
M
R
V
L
V
T
G
G
S
G
Y
I
G
S
H
T
C
V
Q
L
L
Q
N
G
H
D
V
I
I
L
D
N
L
C
---
N
------
S
---
K
---
R
S
V
L
P
V
I
E
R
L
G
G
K
H
P
T
F
V
E
G
D
I
R
N
E
A
L
M
T
E
I
L
H
-
D
H
A
I
D
T
V
I
H
F
A
G
L
K
A
V
G
E
S
V
Q
K
P
L
E
Y
Y
D
N
N
V
N
G
T
L
R
L
I
S
A
M
R
A
A
N
V
K
N
F
I
F
S
S
S
A
T
V
Y
G
----
D
N
P
K
I
P
Y
V
E
S
F
P
-
T
G
T
P
-
Q
S
P
Y
G
K
S
K
L
M
V
E
Q
I
L
T
D
L
Q
K
A
Q
-------------
P
D
-
W
S
I
A
L
L
R
Y
F
N
P
V
G
A
H
P
S
G
D
M
G
E
--
D
P
Q
G
I
P
N
N
L
M
P
Y
I
A
Q
V
A
V
G
R
R
D
S
L
A
I
F
G
N
D
Y
P
T
E
D
G
T
G
V
R
D
Y
I
H
V
M
D
L
A
D
G
H
V
V
A
M
E
K
L
-
A
N
K
P
G
----
V
H
I
Y
N
L
G
A
G
V
G
N
S
V
L
D
V
V
N
A
F
S
K
A
C
G
K
P
V
N
Y
H
F
A
P
R
R
E
G
D
L
P
A
Y
W
A
D
A
S
K
A
D
R
E
L
N
W
R
V
T
R
T
L
D
E
M
A
Q
D
T
W
H
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
87.90
56%
-54
- C1 -
-
1NAH
4
GALE_ECOLI
A:
[1-327]
-
M
R
V
L
V
T
G
G
S
G
Y
I
G
S
H
T
C
V
Q
L
L
Q
N
G
H
D
V
I
I
L
D
N
L
C
---
N
------
S
---
K
---
R
S
V
L
P
V
I
E
R
L
G
G
K
H
P
T
F
V
E
G
D
I
R
N
E
A
L
M
T
E
I
L
H
-
D
H
A
I
D
T
V
I
H
F
A
G
L
K
A
V
G
E
S
V
Q
K
P
L
E
Y
Y
D
N
N
V
N
G
T
L
R
L
I
S
A
M
R
A
A
N
V
K
N
F
I
F
S
S
S
A
T
V
Y
G
----
D
N
P
K
I
P
Y
V
E
S
F
P
-
T
G
T
P
-
Q
S
P
Y
G
K
S
K
L
M
V
E
Q
I
L
T
D
L
Q
K
A
Q
-------------
P
D
-
W
S
I
A
L
L
R
Y
F
N
P
V
G
A
H
P
S
G
D
M
G
E
--
D
P
Q
G
I
P
N
N
L
M
P
Y
I
A
Q
V
A
V
G
R
R
D
S
L
A
I
F
G
N
D
Y
P
T
E
D
G
T
G
V
R
D
Y
I
H
V
M
D
L
A
D
G
H
V
V
A
M
E
K
L
-
A
N
K
P
G
----
V
H
I
Y
N
L
G
A
G
V
G
N
S
V
L
D
V
V
N
A
F
S
K
A
C
G
K
P
V
N
Y
H
F
A
P
R
R
E
G
D
L
P
A
Y
W
A
D
A
S
K
A
D
R
E
L
N
W
R
V
T
R
T
L
D
E
M
A
Q
D
T
W
H
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
87.76
56%
-54
- C1 -
-
1XEL
4
GALE_ECOLI
A:
[1-327]
-
M
R
V
L
V
T
G
G
S
G
Y
I
G
S
H
T
C
V
Q
L
L
Q
N
G
H
D
V
I
I
L
D
N
L
C
---
N
------
S
---
K
---
R
S
V
L
P
V
I
E
R
L
G
G
K
H
P
T
F
V
E
G
D
I
R
N
E
A
L
M
T
E
I
L
H
-
D
H
A
I
D
T
V
I
H
F
A
G
L
K
A
V
G
E
S
V
Q
K
P
L
E
Y
Y
D
N
N
V
N
G
T
L
R
L
I
S
A
M
R
A
A
N
V
K
N
F
I
F
S
S
S
A
T
V
Y
G
----
D
N
P
K
I
P
Y
V
E
S
F
P
-
T
G
T
P
-
Q
S
P
Y
G
K
S
K
L
M
V
E
Q
I
L
T
D
L
Q
K
A
Q
-------------
P
D
-
W
S
I
A
L
L
R
Y
F
N
P
V
G
A
H
P
S
G
D
M
G
E
--
D
P
Q
G
I
P
N
N
L
M
P
Y
I
A
Q
V
A
V
G
R
R
D
S
L
A
I
F
G
N
D
Y
P
T
E
D
G
T
G
V
R
D
Y
I
H
V
M
D
L
A
D
G
H
V
V
A
M
E
K
L
-
A
N
K
P
G
----
V
H
I
Y
N
L
G
A
G
V
G
N
S
V
L
D
V
V
N
A
F
S
K
A
C
G
K
P
V
N
Y
H
F
A
P
R
R
E
G
D
L
P
A
Y
W
A
D
A
S
K
A
D
R
E
L
N
W
R
V
T
R
T
L
D
E
M
A
Q
D
T
W
H
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
84
HHSearch
87.02
56%
-50
- C1 -
-
5GY7
2
GALE_ECOLI
A:
[1-327]
-
M
R
V
L
V
T
G
G
S
G
Y
I
G
S
H
T
C
V
Q
L
L
Q
N
G
H
D
V
I
I
L
D
N
L
C
---
N
------
S
---
K
---
R
S
V
L
P
V
I
E
R
L
G
G
K
H
P
T
F
V
E
G
D
I
R
N
E
A
L
M
T
E
I
L
H
-
D
H
A
I
D
T
V
I
H
F
A
G
L
K
A
V
G
E
S
V
Q
K
P
L
E
Y
Y
D
N
N
V
N
G
T
L
R
L
I
S
A
M
R
A
A
N
V
K
N
F
I
F
S
S
S
A
T
V
Y
G
----
D
Q
P
K
I
P
Y
V
E
S
F
P
T
G
-
T
P
-
Q
S
P
Y
G
K
S
K
L
M
V
E
Q
I
L
T
D
L
Q
K
A
Q
-------------
P
D
-
W
S
I
A
L
L
R
Y
F
N
P
V
G
A
H
P
S
G
D
M
G
E
--
D
P
Q
G
I
P
N
N
L
M
P
Y
I
A
Q
V
A
V
G
R
R
D
S
L
A
I
F
G
N
D
Y
P
T
E
D
G
T
G
V
R
D
Y
I
H
V
M
D
L
A
D
G
I
V
V
A
M
E
K
L
-
A
N
K
P
G
----
V
H
I
Y
N
L
G
A
G
V
G
N
S
V
L
D
V
V
N
A
F
S
K
A
C
G
K
P
V
N
Y
H
F
A
P
R
R
E
G
D
L
P
A
Y
W
A
D
A
S
K
A
D
R
E
L
N
W
R
V
T
R
T
L
D
E
M
A
Q
D
T
W
H
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
PsiBlast_CBE
86.95
55%
-55
- C1 -
-
2UDP
2
GALE_ECOLI
B:
[1-327]
-
M
R
V
L
V
T
G
G
S
G
Y
I
G
S
H
T
C
V
Q
L
L
Q
N
G
H
D
V
I
I
L
D
N
L
C
---
N
------
S
---
K
---
R
S
V
L
P
V
I
E
R
L
G
G
K
H
P
T
F
V
E
G
D
I
R
N
E
A
L
M
T
E
I
L
H
-
D
H
A
I
D
T
V
I
H
F
A
G
L
K
A
V
G
E
S
V
Q
K
P
L
E
Y
Y
D
N
N
V
N
G
T
L
R
L
I
S
A
M
R
A
A
N
V
K
N
F
I
F
S
S
S
A
T
V
Y
G
----
D
Q
P
K
I
P
Y
V
E
S
F
P
-
T
G
T
P
-
Q
S
P
Y
G
K
S
K
L
M
V
E
Q
I
L
T
D
L
Q
K
A
Q
-------------
P
D
-
W
S
I
A
L
L
R
Y
F
N
P
V
G
A
H
P
S
G
D
M
G
E
--
D
P
Q
G
I
P
N
N
L
M
P
Y
I
A
Q
V
A
V
G
R
R
D
S
L
A
I
F
G
N
D
Y
P
T
E
D
G
T
G
V
R
D
Y
I
H
V
M
D
L
A
D
G
H
V
V
A
M
E
K
L
-
A
N
K
P
G
----
V
H
I
Y
N
L
G
A
G
V
G
N
S
V
L
D
V
V
N
A
F
S
K
A
C
G
K
P
V
N
Y
H
F
A
P
R
R
E
G
D
L
P
A
Y
W
A
D
A
S
K
A
D
R
E
L
N
W
R
V
T
R
T
L
D
E
M
A
Q
D
T
W
H
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
86.90
56%
-57
- C1 -
-
1LRL
3
GALE_ECOLI
A:
[1-327]
-
M
R
V
L
V
T
G
G
S
G
Y
I
G
S
H
T
C
V
Q
L
L
Q
N
G
H
D
V
I
I
L
D
N
L
C
---
N
------
S
---
K
---
R
S
V
L
P
V
I
E
R
L
G
G
K
H
P
T
F
V
E
G
D
I
R
N
E
A
L
M
T
E
I
L
H
-
D
H
A
I
D
T
V
I
H
F
A
G
L
K
A
V
G
E
S
V
Q
K
P
L
E
Y
Y
D
N
N
V
N
G
T
L
R
L
I
S
A
M
R
A
A
N
V
K
N
F
I
F
S
S
S
A
T
V
Y
G
----
D
N
P
K
I
P
Y
V
E
S
F
P
-
T
G
T
P
-
Q
S
P
Y
G
K
S
K
L
M
V
E
Q
I
L
T
D
L
Q
K
A
Q
-------------
P
D
-
W
S
I
A
L
L
R
Y
F
N
P
V
G
A
H
P
S
G
D
M
G
E
--
D
P
Q
G
I
P
N
N
L
M
P
Y
I
A
Q
V
A
V
G
R
R
D
S
L
A
I
F
G
N
D
Y
P
T
E
D
G
T
G
V
R
D
Y
I
H
V
M
D
L
A
D
G
H
V
V
A
M
E
K
L
-
A
N
K
P
G
----
V
H
I
Y
N
L
G
A
G
V
G
N
S
V
L
D
V
V
N
A
F
S
K
A
C
G
K
P
V
N
Y
H
F
A
P
R
R
E
G
D
L
P
A
C
W
A
D
A
S
K
A
D
R
E
L
N
W
R
V
T
R
T
L
D
E
M
A
Q
D
T
W
H
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
86.85
55%
-53
- C1 -
-
1UDC
6
GALE_ECOLI
A:
[1-327]
-
M
R
V
L
V
T
G
G
S
G
Y
I
G
S
H
T
C
V
Q
L
L
Q
N
G
H
D
V
I
I
L
D
N
L
C
---
N
------
S
---
K
---
R
S
V
L
P
V
I
E
R
L
G
G
K
H
P
T
F
V
E
G
D
I
R
N
E
A
L
M
T
E
I
L
H
-
D
H
A
I
D
T
V
I
H
F
A
G
L
K
A
V
G
E
S
V
Q
K
P
L
E
Y
Y
D
N
N
V
N
G
T
L
R
L
I
S
A
M
R
A
A
N
V
K
N
F
I
F
S
S
S
A
T
V
Y
G
----
D
Q
P
K
I
P
Y
V
E
S
F
P
-
T
G
T
P
-
Q
S
P
Y
G
K
S
K
L
M
V
E
Q
I
L
T
D
L
Q
K
A
Q
-------------
P
D
-
W
S
I
A
L
L
R
Y
F
N
P
V
G
A
H
P
S
G
D
M
G
E
--
D
P
Q
G
I
P
N
N
L
M
P
Y
I
A
Q
V
A
V
G
R
R
D
S
L
A
I
F
G
N
D
Y
P
T
E
D
G
T
G
V
R
D
Y
I
H
V
M
D
L
A
D
G
H
V
V
A
M
E
K
L
-
A
N
K
P
G
----
V
H
I
Y
N
L
G
A
G
V
G
N
S
V
L
D
V
V
N
A
F
S
K
A
C
G
K
P
V
N
Y
H
F
A
P
R
R
E
G
D
L
P
A
Y
W
A
D
A
S
K
A
D
R
E
L
N
W
R
V
T
R
T
L
D
E
M
A
Q
D
T
W
H
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
86.83
56%
-50
- C1 -
-
1UDA
4
GALE_ECOLI
A:
[1-327]
-
M
R
V
L
V
T
G
G
S
G
Y
I
G
S
H
T
C
V
Q
L
L
Q
N
G
H
D
V
I
I
L
D
N
L
C
---
N
------
S
---
K
---
R
S
V
L
P
V
I
E
R
L
G
G
K
H
P
T
F
V
E
G
D
I
R
N
E
A
L
M
T
E
I
L
H
-
D
H
A
I
D
T
V
I
H
F
A
G
L
K
A
V
G
E
S
V
Q
K
P
L
E
Y
Y
D
N
N
V
N
G
T
L
R
L
I
S
A
M
R
A
A
N
V
K
N
F
I
F
S
S
S
A
T
V
Y
G
----
D
N
P
K
I
P
Y
V
E
S
F
P
-
T
G
T
P
-
Q
S
P
Y
G
K
S
K
L
M
V
E
Q
I
L
T
D
L
Q
K
A
Q
-------------
P
D
-
W
S
I
A
L
L
R
Y
F
N
P
V
G
A
H
P
S
G
D
M
G
E
--
D
P
Q
G
I
P
N
N
L
M
P
Y
I
A
Q
V
A
V
G
R
R
D
S
L
A
I
F
G
N
D
Y
P
T
E
D
G
T
G
V
R
D
Y
I
H
V
M
D
L
A
D
G
H
V
V
A
M
E
K
L
-
A
N
K
P
G
----
V
H
I
Y
N
L
G
A
G
V
G
N
S
V
L
D
V
V
N
A
F
S
K
A
C
G
K
P
V
N
Y
H
F
A
P
R
R
E
G
D
L
P
A
Y
W
A
D
A
S
K
A
D
R
E
L
N
W
R
V
T
R
T
L
D
E
M
A
Q
D
T
W
H
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
86.67
55%
-51
- C1 -
-
1KVU
4
GALE_ECOLI
A:
[1-327]
-
M
R
V
L
V
T
G
G
S
G
Y
I
G
S
H
T
C
V
Q
L
L
Q
N
G
H
D
V
I
I
L
D
N
L
C
---
N
------
S
---
K
---
R
S
V
L
P
V
I
E
R
L
G
G
K
H
P
T
F
V
E
G
D
I
R
N
E
A
L
M
T
E
I
L
H
-
D
H
A
I
D
T
V
I
H
F
A
G
L
K
A
V
G
E
S
V
Q
K
P
L
E
Y
Y
D
N
N
V
N
G
T
L
R
L
I
S
A
M
R
A
A
N
V
K
N
F
I
F
S
S
S
A
T
V
Y
G
----
D
Q
P
K
I
P
Y
V
E
S
F
P
-
T
G
T
P
-
Q
S
P
F
G
K
S
K
L
M
V
E
Q
I
L
T
D
L
Q
K
A
Q
-------------
P
D
-
W
S
I
A
L
L
R
Y
F
N
P
V
G
A
H
P
S
G
D
M
G
E
--
D
P
Q
G
I
P
N
N
L
M
P
Y
I
A
Q
V
A
V
G
R
R
D
S
L
A
I
F
G
N
D
Y
P
T
E
D
G
T
G
V
R
D
Y
I
H
V
M
D
L
A
D
G
H
V
V
A
M
E
K
L
-
A
N
K
P
G
----
V
H
I
Y
N
L
G
A
G
V
G
N
S
V
L
D
V
V
N
A
F
S
K
A
C
G
K
P
V
N
Y
H
F
A
P
R
R
E
G
D
L
P
A
Y
W
A
D
A
S
K
A
D
R
E
L
N
W
R
V
T
R
T
L
D
E
M
A
Q
D
T
W
H
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
74
HHSearch
86.52
55%
-55
* C1 *
-
1A9Y
2
GALE_ECOLI
A:
[1-327]
-
M
R
V
L
V
T
G
G
S
G
Y
I
G
S
H
T
C
V
Q
L
L
Q
N
G
H
D
V
I
I
L
D
N
L
C
---
N
------
S
---
K
---
R
S
V
L
P
V
I
E
R
L
G
G
K
H
P
T
F
V
E
G
D
I
R
N
E
A
L
M
T
E
I
L
H
-
D
H
A
I
D
T
V
I
H
F
A
G
L
K
A
V
G
E
S
V
Q
K
P
L
E
Y
Y
D
N
N
V
N
G
T
L
R
L
I
S
A
M
R
A
A
N
V
K
N
F
I
F
S
S
A
A
T
V
Y
G
----
D
Q
P
K
I
P
Y
V
E
S
F
P
T
G
-
T
P
-
Q
S
P
F
G
K
S
K
L
M
V
E
Q
I
L
T
D
L
Q
K
A
Q
-------------
P
D
-
W
S
I
A
L
L
R
Y
F
N
P
V
G
A
H
P
S
G
D
M
G
E
--
D
P
Q
G
I
P
N
N
L
M
P
Y
I
A
Q
V
A
V
G
R
R
D
S
L
A
I
F
G
N
D
Y
P
T
E
D
G
T
G
V
R
D
Y
I
H
V
M
D
L
A
D
G
H
V
V
A
M
E
K
L
-
A
N
K
P
G
----
V
H
I
Y
N
L
G
A
G
V
G
N
S
V
L
D
V
V
N
A
F
S
K
A
C
G
K
P
V
N
Y
H
F
A
P
R
R
E
G
D
L
P
A
Y
W
A
D
A
S
K
A
D
R
E
L
N
W
R
V
T
R
T
L
D
E
M
A
Q
D
T
W
H
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
86.42
55%
-50
- C1 -
-
5GY7
2
GALE_ECOLI
A:
[1-327]
-
M
R
V
L
V
T
G
G
S
G
Y
I
G
S
H
T
C
V
Q
L
L
Q
N
G
H
D
V
I
I
L
D
N
L
C
---
N
------
S
---
K
---
R
S
V
L
P
V
I
E
R
L
G
G
K
H
P
T
F
V
E
G
D
I
R
N
E
A
L
M
T
E
I
L
H
-
D
H
A
I
D
T
V
I
H
F
A
G
L
K
A
V
G
E
S
V
Q
K
P
L
E
Y
Y
D
N
N
V
N
G
T
L
R
L
I
S
A
M
R
A
A
N
V
K
N
F
I
F
S
S
S
A
T
V
Y
G
----
D
Q
P
K
I
P
Y
V
E
S
F
P
-
T
G
T
P
-
Q
S
P
Y
G
K
S
K
L
M
V
E
Q
I
L
T
D
L
Q
K
A
Q
-------------
P
D
-
W
S
I
A
L
L
R
Y
F
N
P
V
G
A
H
P
S
G
D
M
G
E
--
D
P
Q
G
I
P
N
N
L
M
P
Y
I
A
Q
V
A
V
G
R
R
D
S
L
A
I
F
G
N
D
Y
P
T
E
D
G
T
G
V
R
D
Y
I
H
V
M
D
L
A
D
G
I
V
V
A
M
E
K
L
-
A
N
K
P
G
----
V
H
I
Y
N
L
G
A
G
V
G
N
S
V
L
D
V
V
N
A
F
S
K
A
C
G
K
P
V
N
Y
H
F
A
P
R
R
E
G
D
L
P
A
Y
W
A
D
A
S
K
A
D
R
E
L
N
W
R
V
T
R
T
L
D
E
M
A
Q
D
T
W
H
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
86.25
55%
-53
- C1 -
-
1A9Z
3
GALE_ECOLI
A:
[1-327]
-
M
R
V
L
V
T
G
G
S
G
Y
I
G
S
H
T
C
V
Q
L
L
Q
N
G
H
D
V
I
I
L
D
N
L
C
---
N
------
S
---
K
---
R
S
V
L
P
V
I
E
R
L
G
G
K
H
P
T
F
V
E
G
D
I
R
N
E
A
L
M
T
E
I
L
H
-
D
H
A
I
D
T
V
I
H
F
A
G
L
K
A
V
G
E
S
V
Q
K
P
L
E
Y
Y
D
N
N
V
N
G
T
L
R
L
I
S
A
M
R
A
A
N
V
K
N
F
I
F
S
S
A
A
T
V
Y
G
----
D
N
P
K
I
P
Y
V
E
S
F
P
-
T
G
T
P
-
Q
S
P
F
G
K
S
K
L
M
V
E
Q
I
L
T
D
L
Q
K
A
Q
-------------
P
D
-
W
S
I
A
L
L
R
Y
F
N
P
V
G
A
H
P
S
G
D
M
G
E
--
D
P
Q
G
I
P
N
N
L
M
P
Y
I
A
Q
V
A
V
G
R
R
D
S
L
A
I
F
G
N
D
Y
P
T
E
D
G
T
G
V
R
D
Y
I
H
V
M
D
L
A
D
G
H
V
V
A
M
E
K
L
-
A
N
K
P
G
----
V
H
I
Y
N
L
G
A
G
V
G
N
S
V
L
D
V
V
N
A
F
S
K
A
C
G
K
P
V
N
Y
H
F
A
P
R
R
E
G
D
L
P
A
Y
W
A
D
A
S
K
A
D
R
E
L
N
W
R
V
T
R
T
L
D
E
M
A
Q
D
T
W
H
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
86.11
55%
-55
- C1 -
-
1A9Y
2
GALE_ECOLI
A:
[1-327]
-
M
R
V
L
V
T
G
G
S
G
Y
I
G
S
H
T
C
V
Q
L
L
Q
N
G
H
D
V
I
I
L
D
N
L
C
---
N
------
S
---
K
---
R
S
V
L
P
V
I
E
R
L
G
G
K
H
P
T
F
V
E
G
D
I
R
N
E
A
L
M
T
E
I
L
H
-
D
H
A
I
D
T
V
I
H
F
A
G
L
K
A
V
G
E
S
V
Q
K
P
L
E
Y
Y
D
N
N
V
N
G
T
L
R
L
I
S
A
M
R
A
A
N
V
K
N
F
I
F
S
S
A
A
T
V
Y
G
----
D
Q
P
K
I
P
Y
V
E
S
F
P
-
T
G
T
P
-
Q
S
P
F
G
K
S
K
L
M
V
E
Q
I
L
T
D
L
Q
K
A
Q
-------------
P
D
-
W
S
I
A
L
L
R
Y
F
N
P
V
G
A
H
P
S
G
D
M
G
E
--
D
P
Q
G
I
P
N
N
L
M
P
Y
I
A
Q
V
A
V
G
R
R
D
S
L
A
I
F
G
N
D
Y
P
T
E
D
G
T
G
V
R
D
Y
I
H
V
M
D
L
A
D
G
H
V
V
A
M
E
K
L
-
A
N
K
P
G
----
V
H
I
Y
N
L
G
A
G
V
G
N
S
V
L
D
V
V
N
A
F
S
K
A
C
G
K
P
V
N
Y
H
F
A
P
R
R
E
G
D
L
P
A
Y
W
A
D
A
S
K
A
D
R
E
L
N
W
R
V
T
R
T
L
D
E
M
A
Q
D
T
W
H
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
85.99
55%
-54
- C1 -
-
2UDP
3
GALE_ECOLI
A:
[1-327]
-
M
R
V
L
V
T
G
G
S
G
Y
I
G
S
H
T
C
V
Q
L
L
Q
N
G
H
D
V
I
I
L
D
N
L
C
---
N
------
S
---
K
---
R
S
V
L
P
V
I
E
R
L
G
G
K
H
P
T
F
V
E
G
D
I
R
N
E
A
L
M
T
E
I
L
H
-
D
H
A
I
D
T
V
I
H
F
A
G
L
K
A
V
G
E
S
V
Q
K
P
L
E
Y
Y
D
N
N
V
N
G
T
L
R
L
I
S
A
M
R
A
A
N
V
K
N
F
I
F
S
S
S
A
T
V
Y
G
----
D
Q
P
K
I
P
Y
V
E
S
F
P
-
T
G
T
P
-
Q
S
P
Y
G
K
S
K
L
M
V
E
Q
I
L
T
D
L
Q
K
A
Q
-------------
P
D
-
W
S
I
A
L
L
R
Y
F
N
P
V
G
A
H
P
S
G
D
M
G
E
--
D
P
Q
G
I
P
N
N
L
M
P
Y
I
A
Q
V
A
V
G
R
R
D
S
L
A
I
F
G
N
D
Y
P
T
E
D
G
T
G
V
R
D
Y
I
H
V
M
D
L
A
D
G
H
V
V
A
M
E
K
L
-
A
N
K
P
G
----
V
H
I
Y
N
L
G
A
G
V
G
N
S
V
L
D
V
V
N
A
F
S
K
A
C
G
K
P
V
N
Y
H
F
A
P
R
R
E
G
D
L
P
A
Y
W
A
D
A
S
K
A
D
R
E
L
N
W
R
V
T
R
T
L
D
E
M
A
Q
D
T
W
H
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
85.89
55%
-53
- C1 -
-
1KVR
4
GALE_ECOLI
A:
[1-327]
-
M
R
V
L
V
T
G
G
S
G
Y
I
G
S
H
T
C
V
Q
L
L
Q
N
G
H
D
V
I
I
L
D
N
L
C
---
N
------
S
---
K
---
R
S
V
L
P
V
I
E
R
L
G
G
K
H
P
T
F
V
E
G
D
I
R
N
E
A
L
M
T
E
I
L
H
-
D
H
A
I
D
T
V
I
H
F
A
G
L
K
A
V
G
E
S
V
Q
K
P
L
E
Y
Y
D
N
N
V
N
G
T
L
R
L
I
S
A
M
R
A
A
N
V
K
N
F
I
F
S
S
A
A
T
V
Y
G
----
D
Q
P
K
I
P
Y
V
E
S
F
P
-
T
G
T
P
-
Q
S
P
Y
G
K
S
K
L
M
V
E
Q
I
L
T
D
L
Q
K
A
Q
-------------
P
D
-
W
S
I
A
L
L
R
Y
F
N
P
V
G
A
H
P
S
G
D
M
G
E
--
D
P
Q
G
I
P
N
N
L
M
P
Y
I
A
Q
V
A
V
G
R
R
D
S
L
A
I
F
G
N
D
Y
P
T
E
D
G
T
G
V
R
D
Y
I
H
V
M
D
L
A
D
G
H
V
V
A
M
E
K
L
-
A
N
K
P
G
----
V
H
I
Y
N
L
G
A
G
V
G
N
S
V
L
D
V
V
N
A
F
S
K
A
C
G
K
P
V
N
Y
H
F
A
P
R
R
E
G
D
L
P
A
Y
W
A
D
A
S
K
A
D
R
E
L
N
W
R
V
T
R
T
L
D
E
M
A
Q
D
T
W
H
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
85.68
55%
-54
- C1 -
-
1KVT
3
GALE_ECOLI
A:
[1-327]
-
M
R
V
L
V
T
G
G
S
G
Y
I
G
S
H
T
C
V
Q
L
L
Q
N
G
H
D
V
I
I
L
D
N
L
C
---
N
------
S
---
K
---
R
S
V
L
P
V
I
E
R
L
G
G
K
H
P
T
F
V
E
G
D
I
R
N
E
A
L
M
T
E
I
L
H
-
D
H
A
I
D
T
V
I
H
F
A
G
L
K
A
V
G
E
S
V
Q
K
P
L
E
Y
Y
D
N
N
V
N
G
T
L
R
L
I
S
A
M
R
A
A
N
V
K
N
F
I
F
S
S
V
A
T
V
Y
G
----
D
N
P
K
I
P
Y
V
E
S
F
P
-
T
G
T
P
-
Q
S
P
Y
G
K
S
K
L
M
V
E
Q
I
L
T
D
L
Q
K
A
Q
-------------
P
D
-
W
S
I
A
L
L
R
Y
F
N
P
V
G
A
H
P
S
G
D
M
G
E
--
D
P
Q
G
I
P
N
N
L
M
P
Y
I
A
Q
V
A
V
G
R
R
D
S
L
A
I
F
G
N
D
Y
P
T
E
D
G
T
G
V
R
D
Y
I
H
V
M
D
L
A
D
G
H
V
V
A
M
E
K
L
-
A
N
K
P
G
----
V
H
I
Y
N
L
G
A
G
V
G
N
S
V
L
D
V
V
N
A
F
S
K
A
C
G
K
P
V
N
Y
H
F
A
P
R
R
E
G
D
L
P
A
Y
W
A
D
A
S
K
A
D
R
E
L
N
W
R
V
T
R
T
L
D
E
M
A
Q
D
T
W
H
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
85.29
55%
-57
- C1 -
-
1KVS
3
GALE_ECOLI
A:
[1-327]
-
M
R
V
L
V
T
G
G
S
G
Y
I
G
S
H
T
C
V
Q
L
L
Q
N
G
H
D
V
I
I
L
D
N
L
C
---
N
------
S
---
K
---
R
S
V
L
P
V
I
E
R
L
G
G
K
H
P
T
F
V
E
G
D
I
R
N
E
A
L
M
T
E
I
L
H
-
D
H
A
I
D
T
V
I
H
F
A
G
L
K
A
V
G
E
S
V
Q
K
P
L
E
Y
Y
D
N
N
V
N
G
T
L
R
L
I
S
A
M
R
A
A
N
V
K
N
F
I
F
S
S
T
A
T
V
Y
G
----
D
N
P
K
I
P
Y
V
E
S
F
P
-
T
G
T
P
-
Q
S
P
Y
G
K
S
K
L
M
V
E
Q
I
L
T
D
L
Q
K
A
Q
-------------
P
D
-
W
S
I
A
L
L
R
Y
F
N
P
V
G
A
H
P
S
G
D
M
G
E
--
D
P
Q
G
I
P
N
N
L
M
P
Y
I
A
Q
V
A
V
G
R
R
D
S
L
A
I
F
G
N
D
Y
P
T
E
D
G
T
G
V
R
D
Y
I
H
V
M
D
L
A
D
G
H
V
V
A
M
E
K
L
-
A
N
K
P
G
----
V
H
I
Y
N
L
G
A
G
V
G
N
S
V
L
D
V
V
N
A
F
S
K
A
C
G
K
P
V
N
Y
H
F
A
P
R
R
E
G
D
L
P
A
Y
W
A
D
A
S
K
A
D
R
E
L
N
W
R
V
T
R
T
L
D
E
M
A
Q
D
T
W
H
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
PsiBlast_CBE
85.04
55%
-51
- C1 -
-
5GY7
2
GALE_ECOLI
B:
[1-327]
-
M
R
V
L
V
T
G
G
S
G
Y
I
G
S
H
T
C
V
Q
L
L
Q
N
G
H
D
V
I
I
L
D
N
L
C
---
N
------
S
---
K
---
R
S
V
L
P
V
I
E
R
L
G
G
K
H
P
T
F
V
E
G
D
I
R
N
E
A
L
M
T
E
I
L
H
-
D
H
A
I
D
T
V
I
H
F
A
G
L
K
A
V
G
E
S
V
Q
K
P
L
E
Y
Y
D
N
N
V
N
G
T
L
R
L
I
S
A
M
R
A
A
N
V
K
N
F
I
F
S
S
S
A
T
V
Y
G
----
D
Q
P
K
I
P
Y
V
E
S
F
P
-
T
G
T
P
-
Q
S
P
Y
G
K
S
K
L
M
V
E
Q
I
L
T
D
L
Q
K
A
Q
-------------
P
D
-
W
S
I
A
L
L
R
Y
F
N
P
V
G
A
H
P
S
G
D
M
G
E
--
D
P
Q
G
I
P
N
N
L
M
P
Y
I
A
Q
V
A
V
G
R
R
D
S
L
A
I
F
G
N
D
Y
P
T
E
D
G
T
G
V
R
D
Y
I
H
V
M
D
L
A
D
G
I
V
V
A
M
E
K
L
-
A
N
K
P
G
----
V
H
I
Y
N
L
G
A
G
V
G
N
S
V
L
D
V
V
N
A
F
S
K
A
C
G
K
P
V
N
Y
H
F
A
P
R
R
E
G
D
L
P
A
Y
W
A
D
A
S
K
A
D
R
E
L
N
W
R
V
T
R
T
L
D
E
M
A
Q
D
T
W
H
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
36
PsiBlast_CBE
78.99
53%
-63
- C1 -
-
1Z45
2
GAL10_YEAST
A:
[14-345]
---
V
L
V
T
G
G
A
G
Y
I
G
S
H
T
V
V
E
L
I
E
N
G
Y
D
C
V
V
A
D
N
L
S
---
N
------
S
---
T
---
Y
D
S
V
A
R
L
E
V
L
T
K
H
H
I
P
F
Y
E
V
D
L
C
D
R
K
G
L
E
K
V
F
K
-
E
Y
K
I
D
S
V
I
H
F
A
G
L
K
A
V
G
E
S
T
Q
I
P
L
R
Y
Y
H
N
N
I
L
G
T
V
V
L
L
E
L
M
Q
Q
Y
N
V
S
K
F
V
F
S
S
S
A
T
V
Y
G
DATR
F
P
N
M
I
P
I
P
E
E
C
P
-
L
-
G
P
-
T
N
P
Y
G
H
T
K
Y
A
I
E
N
I
L
N
D
L
Y
N
S
D
-------------
K
K
S
W
K
F
A
I
L
R
Y
F
N
P
I
G
A
H
P
S
G
L
I
G
E
--
D
P
L
G
I
P
N
N
L
L
P
Y
M
A
Q
V
A
V
G
R
R
E
K
L
Y
I
F
------
R
D
G
T
P
I
R
D
Y
I
H
V
V
D
L
A
K
G
H
I
A
A
L
Q
Y
L
-
E
A
Y
N
E
N
E
G
L
C
R
E
W
N
L
G
S
G
K
G
S
T
V
F
E
V
Y
H
A
F
C
K
A
S
G
I
D
L
P
Y
---------
V
L
N
L
T
A
K
P
D
R
A
K
R
E
L
K
W
Q
T
E
L
Q
V
E
D
S
C
K
D
L
W
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
39
PsiBlast_CBE
76.59
46%
-39
- C1 -
-
4LIS
3
?
A:
[5-347]
--
S
V
L
V
T
G
G
T
G
Y
I
G
S
F
T
T
L
A
L
L
E
A
G
Y
K
V
V
V
A
D
N
L
Y
---
N
------
S
---
S
---
A
E
A
L
N
R
I
E
L
I
S
G
K
K
A
E
F
A
Q
L
D
V
T
D
E
A
A
F
D
K
V
F
E
A
H
P
D
I
D
S
V
I
H
F
A
A
L
K
A
V
G
E
S
G
E
K
P
L
D
Y
Y
H
V
N
V
Y
G
T
I
C
L
L
R
S
M
V
R
H
N
V
T
N
I
V
F
S
S
S
A
T
V
Y
G
DATR
F
P
D
M
I
P
I
P
E
H
C
P
-
L
-
G
P
-
T
N
P
Y
G
N
T
K
F
A
I
E
L
A
I
T
D
V
I
N
A
Q
R
N
N
A
K
K
A
GN
E
T
E
A
A
K
-
W
N
G
A
L
L
R
Y
F
N
P
A
G
A
H
P
S
G
I
M
G
E
--
D
P
Q
G
V
P
Y
N
L
L
P
L
L
A
Q
V
A
T
G
K
R
E
K
L
L
V
F
G
D
D
Y
A
S
H
D
G
T
A
I
R
D
Y
I
H
I
L
D
L
A
D
G
H
L
K
A
L
N
Y
L
R
A
N
N
P
G
----
V
R
A
W
N
L
G
T
G
R
G
S
T
V
Y
E
M
I
R
A
F
S
K
A
V
G
R
D
L
P
Y
E
V
A
P
R
R
A
G
D
V
L
N
L
T
S
N
P
T
R
A
N
T
E
L
G
W
K
A
Q
R
T
L
E
Q
A
C
E
D
L
W
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
34
PsiBlast_CBE
76.55
54%
-5
- C1 -
-
1EK6
2
GALE_HUMAN
A:
[5-335]
---
V
L
V
T
G
G
A
G
Y
I
G
S
H
T
V
L
E
L
L
E
A
G
Y
L
P
V
V
I
D
N
F
H
---
N
A
F
R
G
GG
S
---
L
---
P
E
S
L
R
R
V
Q
E
L
T
G
R
S
V
E
F
E
E
M
D
I
L
D
Q
G
A
L
Q
R
L
F
K
-
K
Y
S
F
M
A
V
I
H
F
A
G
L
K
A
V
G
E
S
V
Q
K
P
L
D
Y
Y
R
V
N
L
T
G
T
I
Q
L
L
E
I
M
K
A
H
G
V
K
N
L
V
F
S
S
S
A
T
V
Y
G
----
N
P
Q
Y
L
P
L
D
E
A
H
P
-
T
-
G
G
C
T
N
P
Y
G
K
S
K
F
F
I
E
E
M
I
R
D
L
C
Q
A
D
-------------
K
T
-
W
N
A
V
L
L
R
Y
F
N
P
T
G
A
H
A
S
G
C
I
G
E
--
D
P
Q
G
I
P
N
N
L
M
P
Y
V
S
Q
V
A
I
G
R
R
E
A
L
N
V
F
G
N
D
Y
D
T
E
D
G
T
G
V
R
D
Y
I
H
V
V
D
L
A
K
G
H
I
A
A
L
R
K
L
-
K
E
Q
C
G
----
C
R
I
Y
N
L
G
T
G
T
G
Y
S
V
L
Q
M
V
Q
A
M
E
K
A
S
G
K
K
I
P
Y
K
V
V
A
R
R
E
G
D
V
A
A
C
Y
A
N
P
S
L
A
Q
E
E
L
G
W
T
A
A
L
G
L
D
R
M
C
E
D
L
W
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
76.53
54%
-5
- C1 -
-
1HZJ
2
GALE_HUMAN
A:
[5-335]
---
V
L
V
T
G
G
A
G
Y
I
G
S
H
T
V
L
E
L
L
E
A
G
Y
L
P
V
V
I
D
N
F
H
---
N
AFRGGG
S
---
L
---
P
E
S
L
R
R
V
Q
E
L
T
G
R
S
V
E
F
E
E
M
D
I
L
D
Q
G
A
L
Q
R
L
F
K
-
K
Y
S
F
M
A
V
I
H
F
A
G
L
K
A
V
G
E
S
V
Q
K
P
L
D
Y
Y
R
V
N
L
T
G
T
I
Q
L
L
E
I
M
K
A
H
G
V
K
N
L
V
F
S
S
S
A
T
V
Y
G
----
N
P
Q
Y
L
P
L
D
E
A
H
P
-
T
-
G
G
C
T
N
P
Y
G
K
S
K
F
F
I
E
E
M
I
R
D
L
C
Q
A
D
-------------
K
T
-
W
N
V
V
L
L
R
Y
F
N
P
T
G
A
H
A
S
G
C
I
G
E
--
D
P
Q
G
I
P
N
N
L
M
P
Y
V
S
Q
V
A
I
G
R
R
E
A
L
N
V
F
G
N
D
Y
D
T
E
D
G
T
G
V
R
D
Y
I
H
V
V
D
L
A
K
G
H
I
A
A
L
R
K
L
-
K
E
Q
C
G
----
C
R
I
Y
N
L
G
T
G
T
G
Y
S
V
L
Q
M
V
Q
A
M
E
K
A
S
G
K
K
I
P
Y
K
V
V
A
R
R
E
G
D
V
A
A
C
Y
A
N
P
S
L
A
Q
E
E
L
G
W
T
A
A
L
G
L
D
R
M
C
E
D
L
W
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
37
PsiBlast_CBE
76.16
46%
-37
- C1 -
-
4LIS
2
?
C:
[5-347]
--
S
V
L
V
T
G
G
T
G
Y
I
G
S
F
T
T
L
A
L
L
E
A
G
Y
K
V
V
V
A
D
N
L
Y
---
N
------
S
---
S
---
A
E
A
L
N
R
I
E
L
I
S
G
K
K
A
E
F
A
Q
L
D
V
T
D
E
A
A
F
D
K
V
F
E
A
H
P
D
I
D
S
V
I
H
F
A
A
L
K
A
V
G
E
S
G
E
K
P
L
D
Y
Y
H
V
N
V
Y
G
T
I
C
L
L
R
S
M
V
R
H
N
V
T
N
I
V
F
S
S
S
A
T
V
Y
G
DATR
F
P
D
M
I
P
I
P
E
H
C
P
-
L
-
G
P
-
T
N
P
Y
G
N
T
K
F
A
I
E
L
A
I
T
D
V
I
N
A
Q
RNNAKKAGNETEA
A
K
-
W
N
G
A
L
L
R
Y
F
N
P
A
G
A
H
P
S
G
I
M
G
E
--
D
P
Q
G
V
P
Y
N
L
L
P
L
L
A
Q
V
A
T
G
K
R
E
K
L
L
V
F
G
D
D
Y
A
S
H
D
G
T
A
I
R
D
Y
I
H
I
L
D
L
A
D
G
H
L
K
A
L
N
Y
L
R
A
N
N
P
G
----
V
R
A
W
N
L
G
T
G
R
G
S
T
V
Y
E
M
I
R
A
F
S
K
A
V
G
R
D
L
P
Y
E
V
A
P
R
R
A
G
D
V
L
N
L
T
S
N
P
T
R
A
N
T
E
L
G
W
K
A
Q
R
T
L
E
Q
A
C
E
D
L
W
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
38
PsiBlast_CBE
75.90
46%
-39
- C1 -
-
4LIS
2
?
B:
[5-347]
--
S
V
L
V
T
G
G
T
G
Y
I
G
S
F
T
T
L
A
L
L
E
A
G
Y
K
V
V
V
A
D
N
L
Y
---
N
------
S
---
S
---
A
E
A
L
N
R
I
E
L
I
S
G
K
K
A
E
F
A
Q
L
D
V
T
D
E
A
A
F
D
K
V
F
E
A
H
P
D
I
D
S
V
I
H
F
A
A
L
K
A
V
G
E
S
G
E
K
P
L
D
Y
Y
H
V
N
V
Y
G
T
I
C
L
L
R
S
M
V
R
H
N
V
T
N
I
V
F
S
S
S
A
T
V
Y
G
DATR
F
P
D
M
I
P
I
P
E
H
C
P
-
L
-
G
P
-
T
N
P
Y
G
N
T
K
F
A
I
E
L
A
I
T
D
V
I
N
A
Q
R
N
N
A
K
K
A
GN
E
T
E
A
A
K
-
W
N
G
A
L
L
R
Y
F
N
P
A
G
A
H
P
S
G
I
M
G
E
--
D
P
Q
G
V
P
Y
N
L
L
P
L
L
A
Q
V
A
T
G
K
R
E
K
L
L
V
F
G
D
D
Y
A
S
H
D
G
T
A
I
R
D
Y
I
H
I
L
D
L
A
D
G
H
L
K
A
L
N
Y
L
R
A
N
N
P
G
----
V
R
A
W
N
L
G
T
G
R
G
S
T
V
Y
E
M
I
R
A
F
S
K
A
V
G
R
D
L
P
Y
E
V
A
P
R
R
A
G
D
V
L
N
L
T
S
N
P
T
R
A
N
T
E
L
G
W
K
A
Q
R
T
L
E
Q
A
C
E
D
L
W
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
29
PsiBlast_CBE
75.64
54%
-3
- C1 -
-
1I3L
3
GALE_HUMAN
B:
[5-335]
---
V
L
V
T
G
G
A
G
Y
I
G
S
H
T
V
L
E
L
L
E
A
G
Y
L
P
V
V
I
D
N
F
H
---
N
AFRGGG
S
---
L
---
P
E
S
L
R
R
V
Q
E
L
T
G
R
S
V
E
F
E
E
M
D
I
L
D
Q
G
A
L
Q
R
L
F
K
-
K
Y
S
F
M
A
V
I
H
F
A
G
L
K
A
M
G
E
S
V
Q
K
P
L
D
Y
Y
R
V
N
L
T
G
T
I
Q
L
L
E
I
M
K
A
H
G
V
K
N
L
V
F
S
S
S
A
T
V
Y
G
----
N
P
Q
Y
L
P
L
D
E
A
H
P
-
T
-
G
G
C
T
N
P
Y
G
K
S
K
F
F
I
E
E
M
I
R
D
L
C
Q
A
D
-------------
K
T
-
W
N
V
V
L
L
R
Y
F
N
P
T
G
A
H
A
S
G
C
I
G
E
--
D
P
Q
G
I
P
N
N
L
M
P
Y
V
S
Q
V
A
I
G
R
R
E
A
L
N
V
F
G
N
D
Y
D
T
E
D
G
T
G
V
R
D
Y
I
H
V
V
D
L
A
K
G
H
I
A
A
L
R
K
L
-
K
E
Q
C
G
----
C
R
I
Y
N
L
G
T
G
T
G
Y
S
V
L
Q
M
V
Q
A
M
E
K
A
S
G
K
K
I
P
Y
K
V
V
A
R
R
E
G
D
V
A
A
C
Y
A
N
P
S
L
A
Q
E
E
L
G
W
T
A
A
L
G
L
D
R
M
C
E
D
L
W
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
82
HHSearch
75.44
55%
-4
- C1 -
-
1I3K
4
GALE_HUMAN
B:
[3-335]
-
E
K
V
L
V
T
G
G
A
G
Y
I
G
S
H
T
V
L
E
L
L
E
A
G
Y
L
P
V
V
I
D
N
F
H
---
N
------
A
FRG
G
GSL
P
E
S
L
R
R
V
Q
E
L
T
G
R
S
V
E
F
E
E
M
D
I
L
D
Q
G
A
L
Q
R
L
F
K
-
K
Y
S
F
M
A
V
I
H
F
A
G
L
K
A
M
G
E
S
V
Q
K
P
L
D
Y
Y
R
V
N
L
T
G
T
I
Q
L
L
E
I
M
K
A
H
G
V
K
N
L
V
F
S
S
S
A
T
V
Y
G
----
N
P
Q
Y
L
P
L
D
E
A
H
P
-
T
-
G
G
C
T
N
P
Y
G
K
S
K
F
F
I
E
E
M
I
R
D
L
C
Q
A
D
-------------
K
T
-
W
N
V
V
L
L
R
Y
F
N
P
T
G
A
H
A
S
G
C
I
G
E
--
D
P
Q
G
I
P
N
N
L
M
P
Y
V
S
Q
V
A
I
G
R
R
E
A
L
N
V
F
G
N
D
Y
D
T
E
D
G
T
G
V
R
D
Y
I
H
V
V
D
L
A
K
G
H
I
A
A
L
R
K
L
-
K
E
Q
C
G
----
C
R
I
Y
N
L
G
T
G
T
G
Y
S
V
L
Q
M
V
Q
A
M
E
K
A
S
G
K
K
I
P
Y
K
V
V
A
R
R
E
G
D
V
A
A
C
Y
A
N
P
S
L
A
Q
E
E
L
G
W
T
A
A
L
G
L
D
R
M
C
E
D
L
W
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
30
PsiBlast_CBE
74.85
54%
-7
- C1 -
-
1I3L
3
GALE_HUMAN
A:
[5-335]
---
V
L
V
T
G
G
A
G
Y
I
G
S
H
T
V
L
E
L
L
E
A
G
Y
L
P
V
V
I
D
N
F
H
---
N
A
F
R
G
GG
S
---
L
---
P
E
S
L
R
R
V
Q
E
L
T
G
R
S
V
E
F
E
E
M
D
I
L
D
Q
G
A
L
Q
R
L
F
K
-
K
Y
S
F
M
A
V
I
H
F
A
G
L
K
A
M
G
E
S
V
Q
K
P
L
D
Y
Y
R
V
N
L
T
G
T
I
Q
L
L
E
I
M
K
A
H
G
V
K
N
L
V
F
S
S
S
A
T
V
Y
G
----
N
P
Q
Y
L
P
L
D
E
A
H
P
-
T
-
G
G
C
T
N
P
Y
G
K
S
K
F
F
I
E
E
M
I
R
D
L
C
Q
A
D
-------------
K
T
-
W
N
V
V
L
L
R
Y
F
N
P
T
G
A
H
A
S
G
C
I
G
E
--
D
P
Q
G
I
P
N
N
L
M
P
Y
V
S
Q
V
A
I
G
R
R
E
A
L
N
V
F
G
N
D
Y
D
T
E
D
G
T
G
V
R
D
Y
I
H
V
V
D
L
A
K
G
H
I
A
A
L
R
K
L
-
K
E
Q
C
G
----
C
R
I
Y
N
L
G
T
G
T
G
Y
S
V
L
Q
M
V
Q
A
M
E
K
A
S
G
K
K
I
P
Y
K
V
V
A
R
R
E
G
D
V
A
A
C
Y
A
N
P
S
L
A
Q
E
E
L
G
W
T
A
A
L
G
L
D
R
M
C
E
D
L
W
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
81
HHSearch
74.83
55%
-4
- C1 -
-
1I3N
2
GALE_HUMAN
A:
[3-335]
-
E
K
V
L
V
T
G
G
A
G
Y
I
G
S
H
T
V
L
E
L
L
E
A
G
Y
L
P
V
V
I
D
N
F
H
---
N
------
A
F
R
G
G
GSL
P
E
S
L
R
R
V
Q
E
L
T
G
R
S
V
E
F
E
E
M
D
I
L
D
Q
G
A
L
Q
R
L
F
K
-
K
Y
S
F
M
A
V
I
H
F
A
G
L
K
A
M
G
E
S
V
Q
K
P
L
D
Y
Y
R
V
N
L
T
G
T
I
Q
L
L
E
I
M
K
A
H
G
V
K
N
L
V
F
S
S
S
A
T
V
Y
G
----
N
P
Q
Y
L
P
L
D
E
A
H
P
-
T
-
G
G
C
T
N
P
Y
G
K
S
K
F
F
I
E
E
M
I
R
D
L
C
Q
A
D
-------------
K
T
-
W
N
V
V
L
L
R
Y
F
N
P
T
G
A
H
A
S
G
C
I
G
E
--
D
P
Q
G
I
P
N
N
L
M
P
Y
V
S
Q
V
A
I
G
R
R
E
A
L
N
V
F
G
N
D
Y
D
T
E
D
G
T
G
V
R
D
Y
I
H
V
V
D
L
A
K
G
H
I
A
A
L
R
K
L
-
K
E
Q
C
G
----
C
R
I
Y
N
L
G
T
G
T
G
Y
S
V
L
Q
M
V
Q
A
M
E
K
A
S
G
K
K
I
P
Y
K
V
V
A
R
R
E
G
D
V
A
A
C
Y
A
N
P
S
L
A
Q
E
E
L
G
W
T
A
A
L
G
L
D
R
M
C
E
D
L
W
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
28
PsiBlast_CBE
74.77
54%
-6
- C1 -
-
1I3M
2
GALE_HUMAN
A:
[5-335]
---
V
L
V
T
G
G
A
G
Y
I
G
S
H
T
V
L
E
L
L
E
A
G
Y
L
P
V
V
I
D
N
F
H
---
N
A
F
R
G
GG
S
---
L
---
P
E
S
L
R
R
V
Q
E
L
T
G
R
S
V
E
F
E
E
M
D
I
L
D
Q
G
A
L
Q
R
L
F
K
-
K
Y
S
F
M
A
V
I
H
F
A
G
L
K
A
M
G
E
S
V
Q
K
P
L
D
Y
Y
R
V
N
L
T
G
T
I
Q
L
L
E
I
M
K
A
H
G
V
K
N
L
V
F
S
S
S
A
T
V
Y
G
----
N
P
Q
Y
L
P
L
D
E
A
H
P
-
T
-
G
G
C
T
N
P
Y
G
K
S
K
F
F
I
E
E
M
I
R
D
L
C
Q
A
D
-------------
K
T
-
W
N
V
V
L
L
R
Y
F
N
P
T
G
A
H
A
S
G
C
I
G
E
--
D
P
Q
G
I
P
N
N
L
M
P
Y
V
S
Q
V
A
I
G
R
R
E
A
L
N
V
F
G
N
D
Y
D
T
E
D
G
T
G
V
R
D
Y
I
H
V
V
D
L
A
K
G
H
I
A
A
L
R
K
L
-
K
E
Q
C
G
----
C
R
I
Y
N
L
G
T
G
T
G
Y
S
V
L
Q
M
V
Q
A
M
E
K
A
S
G
K
K
I
P
Y
K
V
V
A
R
R
E
G
D
V
A
A
C
Y
A
N
P
S
L
A
Q
E
E
L
G
W
T
A
A
L
G
L
D
R
M
C
E
D
L
W
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
35
PsiBlast_CBE
74.42
54%
-3
- C1 -
-
1EK5
1
GALE_HUMAN
A:
[5-335]
---
V
L
V
T
G
G
A
G
Y
I
G
S
H
T
V
L
E
L
L
E
A
G
Y
L
P
V
V
I
D
N
F
H
---
N
A
F
R
G
GG
S
---
L
---
P
E
S
L
R
R
V
Q
E
L
T
G
R
S
V
E
F
E
E
M
D
I
L
D
Q
G
A
L
Q
R
L
F
K
-
K
Y
S
F
M
A
V
I
H
F
A
G
L
K
A
V
G
E
S
V
Q
K
P
L
D
Y
Y
R
V
N
L
T
G
T
I
Q
L
L
E
I
M
K
A
H
G
V
K
N
L
V
F
S
S
S
A
T
V
Y
G
----
N
P
Q
Y
L
P
L
D
E
A
H
P
-
T
-
G
G
C
T
N
P
Y
G
K
S
K
F
F
I
E
E
M
I
R
D
L
C
Q
A
D
-------------
K
T
-
W
N
A
V
L
L
R
Y
F
N
P
T
G
A
H
A
S
G
C
I
G
E
--
D
P
Q
G
I
P
N
N
L
M
P
Y
V
S
Q
V
A
I
G
R
R
E
A
L
N
V
F
G
N
D
Y
D
T
E
D
G
T
G
V
R
D
Y
I
H
V
V
D
L
A
K
G
H
I
A
A
L
R
K
L
-
K
E
Q
C
G
----
C
R
I
Y
N
L
G
T
G
T
G
Y
S
V
L
Q
M
V
Q
A
M
E
K
A
S
G
K
K
I
P
Y
K
V
V
A
R
R
E
G
D
V
A
A
C
Y
A
N
P
S
L
A
Q
E
E
L
G
W
T
A
A
L
G
L
D
R
M
C
E
D
L
W
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
32
PsiBlast_CBE
74.26
54%
-6
- C1 -
-
1I3K
3
GALE_HUMAN
A:
[5-335]
---
V
L
V
T
G
G
A
G
Y
I
G
S
H
T
V
L
E
L
L
E
A
G
Y
L
P
V
V
I
D
N
F
H
---
N
A
F
R
G
GG
S
---
L
---
P
E
S
L
R
R
V
Q
E
L
T
G
R
S
V
E
F
E
E
M
D
I
L
D
Q
G
A
L
Q
R
L
F
K
-
K
Y
S
F
M
A
V
I
H
F
A
G
L
K
A
M
G
E
S
V
Q
K
P
L
D
Y
Y
R
V
N
L
T
G
T
I
Q
L
L
E
I
M
K
A
H
G
V
K
N
L
V
F
S
S
S
A
T
V
Y
G
----
N
P
Q
Y
L
P
L
D
E
A
H
P
-
T
-
G
G
C
T
N
P
Y
G
K
S
K
F
F
I
E
E
M
I
R
D
L
C
Q
A
D
-------------
K
T
-
W
N
V
V
L
L
R
Y
F
N
P
T
G
A
H
A
S
G
C
I
G
E
--
D
P
Q
G
I
P
N
N
L
M
P
Y
V
S
Q
V
A
I
G
R
R
E
A
L
N
V
F
G
N
D
Y
D
T
E
D
G
T
G
V
R
D
Y
I
H
V
V
D
L
A
K
G
H
I
A
A
L
R
K
L
-
K
E
Q
C
G
----
C
R
I
Y
N
L
G
T
G
T
G
Y
S
V
L
Q
M
V
Q
A
M
E
K
A
S
G
K
K
I
P
Y
K
V
V
A
R
R
E
G
D
V
A
A
C
Y
A
N
P
S
L
A
Q
E
E
L
G
W
T
A
A
L
G
L
D
R
M
C
E
D
L
W
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
61
Fugue
74.04
53%
-2
- C1 -
-
1Z45
3
GAL10_YEAST
A:
[11-699]
S
K
I
V
L
V
T
G
G
A
G
Y
I
G
S
H
T
V
V
E
L
I
E
N
G
Y
D
C
V
V
A
D
N
L
S
---
N
------
S
---
T
---
Y
D
S
V
A
R
L
E
V
L
T
K
H
H
I
P
F
Y
E
V
D
L
C
D
R
K
G
L
E
K
V
F
K
-
E
Y
K
I
D
S
V
I
H
F
A
G
L
K
A
V
G
E
S
T
Q
I
P
L
R
Y
Y
H
N
N
I
L
G
T
V
V
L
L
E
L
M
Q
Q
Y
N
V
S
K
F
V
F
S
S
S
A
T
V
Y
G
DATR
F
P
N
M
I
P
I
P
E
E
C
P
-
L
-
G
P
-
T
N
P
Y
G
H
T
K
Y
A
I
E
N
I
L
N
D
L
Y
N
S
D
-------------
K
K
S
W
K
F
A
I
L
R
Y
F
N
P
I
G
A
H
P
S
G
L
I
G
E
--
D
P
L
G
I
P
N
N
L
L
P
Y
M
A
Q
V
A
V
G
R
R
E
K
L
Y
I
F
R
------
D
G
T
P
I
R
D
Y
I
H
V
V
D
L
A
K
G
H
I
A
A
L
Q
Y
L
-
E
A
Y
N
E
N
E
G
L
C
R
E
W
N
L
G
S
G
K
G
S
T
V
F
E
V
Y
H
A
F
C
K
A
S
G
I
D
L
P
Y
V
L
---------
N
L
T
A
K
P
D
R
A
K
R
E
L
K
W
Q
T
E
L
Q
V
E
D
S
C
K
D
L
W
K
W
T
T
E
N
P
FGYQLRG
V
E
A
R
F
SAEDMRYDA
R
F
V
T
I
GAGTR
F
Q
A
T
F
A
NLGASIV
D
L
K
V
NGQSV
V
L
G
Y
EN
E
E
G
Y
L
NPDSAYIGATIGRYANRISKG
K
F
S
L
CN
K
D
Y
Q
L
TVNNGVNANHSSIGSFHR
K
R
F
L
G
P
I
I
Q
NPSKD
V
F
T
A
E
Y
M
L
I
D
N
EKDTEFP
G
D
L
L
V
T
I
Q
Y
T
V
N
VAQK
S
L
E
I
V
Y
K
G
K
L
TAGE
A
T
P
I
N
L
T
N
H
S
Y
F
N
LNKPYGDTIEG
T
E
I
M
V
RSK
K
S
V
D
V
D
KNMIPTG
N
I
V
D
R
EIATFNSTK
P
T
V
L
G
PKNP
Q
F
D
C
C
F
V
VDENAKPSQINTLNNELTLI
V
K
A
F
H
PDSN
I
T
L
E
V
L
S
TEP
T
Y
Q
F
Y
TGDFLSAGYEARQ
G
F
A
I
E
P
G
RYIDAINQENWKDCVTLKNG
E
T
Y
G
S
K
I
V
Y
R
F
S
31
PsiBlast_CBE
73.70
54%
-4
- C1 -
-
1I3K
4
GALE_HUMAN
B:
[5-335]
---
V
L
V
T
G
G
A
G
Y
I
G
S
H
T
V
L
E
L
L
E
A
G
Y
L
P
V
V
I
D
N
F
H
---
N
AFRGGG
S
---
L
---
P
E
S
L
R
R
V
Q
E
L
T
G
R
S
V
E
F
E
E
M
D
I
L
D
Q
G
A
L
Q
R
L
F
K
-
K
Y
S
F
M
A
V
I
H
F
A
G
L
K
A
M
G
E
S
V
Q
K
P
L
D
Y
Y
R
V
N
L
T
G
T
I
Q
L
L
E
I
M
K
A
H
G
V
K
N
L
V
F
S
S
S
A
T
V
Y
G
----
N
P
Q
Y
L
P
L
D
E
A
H
P
-
T
-
G
G
C
T
N
P
Y
G
K
S
K
F
F
I
E
E
M
I
R
D
L
C
Q
A
D
-------------
K
T
-
W
N
V
V
L
L
R
Y
F
N
P
T
G
A
H
A
S
G
C
I
G
E
--
D
P
Q
G
I
P
N
N
L
M
P
Y
V
S
Q
V
A
I
G
R
R
E
A
L
N
V
F
G
N
D
Y
D
T
E
D
G
T
G
V
R
D
Y
I
H
V
V
D
L
A
K
G
H
I
A
A
L
R
K
L
-
K
E
Q
C
G
----
C
R
I
Y
N
L
G
T
G
T
G
Y
S
V
L
Q
M
V
Q
A
M
E
K
A
S
G
K
K
I
P
Y
K
V
V
A
R
R
E
G
D
V
A
A
C
Y
A
N
P
S
L
A
Q
E
E
L
G
W
T
A
A
L
G
L
D
R
M
C
E
D
L
W
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
PsiBlast_CBE
73.55
54%
-4
- C1 -
-
1HZJ
2
GALE_HUMAN
B:
[5-335]
---
V
L
V
T
G
G
A
G
Y
I
G
S
H
T
V
L
E
L
L
E
A
G
Y
L
P
V
V
I
D
N
F
H
---
N
AFRGGG
S
---
L
---
P
E
S
L
R
R
V
Q
E
L
T
G
R
S
V
E
F
E
E
M
D
I
L
D
Q
G
A
L
Q
R
L
F
K
-
K
Y
S
F
M
A
V
I
H
F
A
G
L
K
A
V
G
E
S
V
Q
K
P
L
D
Y
Y
R
V
N
L
T
G
T
I
Q
L
L
E
I
M
K
A
H
G
V
K
N
L
V
F
S
S
S
A
T
V
Y
G
----
N
P
Q
Y
L
P
L
D
E
A
H
P
-
T
-
G
G
C
T
N
P
Y
G
K
S
K
F
F
I
E
E
M
I
R
D
L
C
Q
A
D
-------------
K
T
-
W
N
V
V
L
L
R
Y
F
N
P
T
G
A
H
A
S
G
C
I
G
E
--
D
P
Q
G
I
P
N
N
L
M
P
Y
V
S
Q
V
A
I
G
R
R
E
A
L
N
V
F
G
N
D
Y
D
T
E
D
G
T
G
V
R
D
Y
I
H
V
V
D
L
A
K
G
H
I
A
A
L
R
K
L
-
K
E
Q
C
G
----
C
R
I
Y
N
L
G
T
G
T
G
Y
S
V
L
Q
M
V
Q
A
M
E
K
A
S
G
K
K
I
P
Y
K
V
V
A
R
R
E
G
D
V
A
A
C
Y
A
N
P
S
L
A
Q
E
E
L
G
W
T
A
A
L
G
L
D
R
M
C
E
D
L
W
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
27
PsiBlast_CBE
73.50
54%
-4
- C1 -
-
1I3M
2
GALE_HUMAN
B:
[5-335]
---
V
L
V
T
G
G
A
G
Y
I
G
S
H
T
V
L
E
L
L
E
A
G
Y
L
P
V
V
I
D
N
F
H
---
N
AFRGGG
S
---
L
---
P
E
S
L
R
R
V
Q
E
L
T
G
R
S
V
E
F
E
E
M
D
I
L
D
Q
G
A
L
Q
R
L
F
K
-
K
Y
S
F
M
A
V
I
H
F
A
G
L
K
A
M
G
E
S
V
Q
K
P
L
D
Y
Y
R
V
N
L
T
G
T
I
Q
L
L
E
I
M
K
A
H
G
V
K
N
L
V
F
S
S
S
A
T
V
Y
G
----
N
P
Q
Y
L
P
L
D
E
A
H
P
-
T
-
G
G
C
T
N
P
Y
G
K
S
K
F
F
I
E
E
M
I
R
D
L
C
Q
A
D
-------------
K
T
-
W
N
V
V
L
L
R
Y
F
N
P
T
G
A
H
A
S
G
C
I
G
E
--
D
P
Q
G
I
P
N
N
L
M
P
Y
V
S
Q
V
A
I
G
R
R
E
A
L
N
V
F
G
N
D
Y
D
T
E
D
G
T
G
V
R
D
Y
I
H
V
V
D
L
A
K
G
H
I
A
A
L
R
K
L
-
K
E
Q
C
G
----
C
R
I
Y
N
L
G
T
G
T
G
Y
S
V
L
Q
M
V
Q
A
M
E
K
A
S
G
K
K
I
P
Y
K
V
V
A
R
R
E
G
D
V
A
A
C
Y
A
N
P
S
L
A
Q
E
E
L
G
W
T
A
A
L
G
L
D
R
M
C
E
D
L
W
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
26
PsiBlast_CBE
73.22
54%
-4
- C1 -
-
1I3N
2
GALE_HUMAN
A:
[5-335]
---
V
L
V
T
G
G
A
G
Y
I
G
S
H
T
V
L
E
L
L
E
A
G
Y
L
P
V
V
I
D
N
F
H
---
N
A
F
R
G
GG
S
---
L
---
P
E
S
L
R
R
V
Q
E
L
T
G
R
S
V
E
F
E
E
M
D
I
L
D
Q
G
A
L
Q
R
L
F
K
-
K
Y
S
F
M
A
V
I
H
F
A
G
L
K
A
M
G
E
S
V
Q
K
P
L
D
Y
Y
R
V
N
L
T
G
T
I
Q
L
L
E
I
M
K
A
H
G
V
K
N
L
V
F
S
S
S
A
T
V
Y
G
----
N
P
Q
Y
L
P
L
D
E
A
H
P
-
T
-
G
G
C
T
N
P
Y
G
K
S
K
F
F
I
E
E
M
I
R
D
L
C
Q
A
D
-------------
K
T
-
W
N
V
V
L
L
R
Y
F
N
P
T
G
A
H
A
S
G
C
I
G
E
--
D
P
Q
G
I
P
N
N
L
M
P
Y
V
S
Q
V
A
I
G
R
R
E
A
L
N
V
F
G
N
D
Y
D
T
E
D
G
T
G
V
R
D
Y
I
H
V
V
D
L
A
K
G
H
I
A
A
L
R
K
L
-
K
E
Q
C
G
----
C
R
I
Y
N
L
G
T
G
T
G
Y
S
V
L
Q
M
V
Q
A
M
E
K
A
S
G
K
K
I
P
Y
K
V
V
A
R
R
E
G
D
V
A
A
C
Y
A
N
P
S
L
A
Q
E
E
L
G
W
T
A
A
L
G
L
D
R
M
C
E
D
L
W
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
25
PsiBlast_CBE
72.80
54%
-4
- C1 -
-
1I3N
2
GALE_HUMAN
B:
[5-335]
---
V
L
V
T
G
G
A
G
Y
I
G
S
H
T
V
L
E
L
L
E
A
G
Y
L
P
V
V
I
D
N
F
H
---
N
AFRGGG
S
---
L
---
P
E
S
L
R
R
V
Q
E
L
T
G
R
S
V
E
F
E
E
M
D
I
L
D
Q
G
A
L
Q
R
L
F
K
-
K
Y
S
F
M
A
V
I
H
F
A
G
L
K
A
M
G
E
S
V
Q
K
P
L
D
Y
Y
R
V
N
L
T
G
T
I
Q
L
L
E
I
M
K
A
H
G
V
K
N
L
V
F
S
S
S
A
T
V
Y
G
----
N
P
Q
Y
L
P
L
D
E
A
H
P
-
T
-
G
G
C
T
N
P
Y
G
K
S
K
F
F
I
E
E
M
I
R
D
L
C
Q
A
D
-------------
K
T
-
W
N
V
V
L
L
R
Y
F
N
P
T
G
A
H
A
S
G
C
I
G
E
--
D
P
Q
G
I
P
N
N
L
M
P
Y
V
S
Q
V
A
I
G
R
R
E
A
L
N
V
F
G
N
D
Y
D
T
E
D
G
T
G
V
R
D
Y
I
H
V
V
D
L
A
K
G
H
I
A
A
L
R
K
L
-
K
E
Q
C
G
----
C
R
I
Y
N
L
G
T
G
T
G
Y
S
V
L
Q
M
V
Q
A
M
E
K
A
S
G
K
K
I
P
Y
K
V
V
A
R
R
E
G
D
V
A
A
C
Y
A
N
P
S
L
A
Q
E
E
L
G
W
T
A
A
L
G
L
D
R
M
C
E
D
L
W
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
33
PsiBlast_CBE
72.73
54%
-6
- C1 -
-
1EK6
2
GALE_HUMAN
B:
[5-335]
---
V
L
V
T
G
G
A
G
Y
I
G
S
H
T
V
L
E
L
L
E
A
G
Y
L
P
V
V
I
D
N
F
H
---
N
A
F
R
G
GG
S
---
L
---
P
E
S
L
R
R
V
Q
E
L
T
G
R
S
V
E
F
E
E
M
D
I
L
D
Q
G
A
L
Q
R
L
F
K
-
K
Y
S
F
M
A
V
I
H
F
A
G
L
K
A
V
G
E
S
V
Q
K
P
L
D
Y
Y
R
V
N
L
T
G
T
I
Q
L
L
E
I
M
K
A
H
G
V
K
N
L
V
F
S
S
S
A
T
V
Y
G
----
N
P
Q
Y
L
P
L
D
E
A
H
P
-
T
-
G
G
C
T
N
P
Y
G
K
S
K
F
F
I
E
E
M
I
R
D
L
C
Q
A
D
-------------
K
T
-
W
N
A
V
L
L
R
Y
F
N
P
T
G
A
H
A
S
G
C
I
G
E
--
D
P
Q
G
I
P
N
N
L
M
P
Y
V
S
Q
V
A
I
G
R
R
E
A
L
N
V
F
G
N
D
Y
D
T
E
D
G
T
G
V
R
D
Y
I
H
V
V
D
L
A
K
G
H
I
A
A
L
R
K
L
-
K
E
Q
C
G
----
C
R
I
Y
N
L
G
T
G
T
G
Y
S
V
L
Q
M
V
Q
A
M
E
K
A
S
G
K
K
I
P
Y
K
V
V
A
R
R
E
G
D
V
A
A
C
Y
A
N
P
S
L
A
Q
E
E
L
G
W
T
A
A
L
G
L
D
R
M
C
E
D
L
W
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
47
PsiBlast_CBE
63.09
37%
-19
- C1 -
-
4TWR
1
?
A:
[14-317]
---
V
L
V
V
G
G
A
G
F
I
G
S
H
T
A
K
L
L
A
G
Q
G
Y
A
P
V
V
Y
D
N
L
S
TGH
Q
------
S
---
A
---
V
R
W
G
D
-----------
F
V
E
G
D
I
L
D
Q
A
R
L
V
E
T
M
E
-
K
Y
A
P
V
A
V
I
H
F
A
A
S
A
Y
V
G
E
S
V
E
D
P
A
K
Y
Y
R
N
N
V
G
G
T
Q
S
L
L
D
A
C
R
L
T
R
T
Q
N
V
I
F
S
S
S
C
A
T
Y
G
----
V
P
S
R
L
P
I
G
E
G
E
A
-
Q
-
N
P
-
I
N
P
Y
G
R
T
K
L
I
A
E
H
M
L
A
D
Y
A
V
A
Y
-------------
G
L
-
R
Y
V
A
L
-
R
Y
F
N
A
S
G
A
D
I
D
G
E
L
G
E
K
H
D
P
E
---
T
H
L
I
P
R
A
M
M
A
A
A
G
R
L
D
V
L
E
V
Y
G
D
D
Y
E
T
P
D
G
T
C
I
R
D
Y
I
H
V
T
D
L
A
R
A
H
V
L
A
V
E
H
L
-
K
E
A
G
G
----
N
L
A
V
N
L
G
T
G
R
G
T
S
I
R
E
I
V
Q
S
I
G
R
L
T
G
R
S
V
P
V
A
M
R
A
R
R
A
G
D
P
P
A
L
Y
A
D
P
A
L
A
A
E
K
L
G
F
H
T
V
Y
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------