@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : spr1704: (2018-01-18 )
MTKEKNVILTARDIVVEFDVRDKVLTAIRGVSLELVEGEVLALVGESGSGKSVLTKTFTGMLEENGRIAQGSIDYRGQDLTALSSHKDWEQIRGAKIATIFQDPMTSLDPIKTIGSQITEVIVKHQGKTAKEAKELAIDYMNKVGIPDADRRFNEYPFQYSGGMRQRIVIAIALACRPDVLICDEPTTALDVTIQAQIIDLLKSLQNEYHFTTIFITHDLGVVASIADKVAVMYAGEIVEYGTVEEVFYDPRHPYTWSLLSSLPQLADDKGDLYSIPGTPPSLYTDLKGDAFALRSDYAMQIDFEQKAPQFSVSETHWAKTWLLHEDAPKVEKPAVIANLHDKIREKMGFAHLAD
Atome Classification :
(45 SA)
.........10........20........30........40........50........60-........70........80--........90........100...----....110...--.....120...----..-.-.130-.......140...-....150..----.....160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270....-----...280.......290.......300.......310.......320.......330.......340.......350...
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MTKEK
N
V
I
L
T
A
R
D
I
V
V
E
F
DV
R
D
K
V
L
T
A
IRG
V
S
L
E
L
VE
G
E
V
L
A
L
VGESGSGK
S
V
L
T
K
T
F
T
G
M
-
L
EENGRIAQGSIDYRGQD
L
T
--
A
LSSHK
D
W
E
Q
IRG
A
K
I
A
T
IFQDPM----TSL
D
P
I
-
K
T
I
--
G
S
Q
I
T
E
V
I
V
KH----QG-
K
-
T
A
K
E
-
A
K
E
L
A
I
D
Y
M
N
KVG-IP
D
A
DRRFN----EYPFQYSGGM
R
Q
R
I
V
I
A
I
A
LACRP
D
V
L
I
CDEPT
T
A
L
D
V
T
I
Q
A
Q
I
I
D
L
L
K
S
L
QNEY
H
F
T
T
I
F
I
THD
L
G
V
V
A
S
I
A
D
K
V
A
V
MYAGEIVEYG
T
V
E
E
V
FYDPRHP
Y
T
W
S
L
L
S
S
L
P
Q
L
ADDKG
D
L
Y
SI-----PGTP
P
S
L
Y
TDLKG
D
A
F
A
LRS
D
Y
A
M
Q
I
D
FEQKAPQFSVSETH
W
A
K
T
W
L
LHEDAPKVEK
P
A
V
I
A
N
L
H
D
K
I
R
E
K
MGFAHLAD
100
HHSearch
86.36
38%
-79
- C1 -
-
4FWI
2
?
B:
[2-321]
-----
S
I
I
I
R
V
E
D
L
R
A
V
Y
L
V
R
E
G
T
I
K
A
A
D
G
I
S
L
D
I
L
E
N
S
V
T
A
I
V
G
E
S
A
S
G
K
S
T
I
I
E
A
M
T
K
T
-
L
P
P
N
G
R
I
L
S
G
R
V
L
Y
K
G
K
D
L
L
--
T
M
R
-
E
E
E
L
R
K
I
R
W
K
E
I
A
L
V
P
Q
A
A
Q
----
Q
S
L
N
P
T
-
M
K
V
--
I
E
H
F
K
D
T
V
E
A
H
----
G
V
R
W
-
S
H
S
E
-
L
I
E
K
A
S
E
K
L
R
M
V
R
-
L
N
P
-
E
A
V
L
N
----
S
Y
P
L
Q
L
S
G
G
M
K
Q
R
V
L
I
A
L
A
L
L
L
D
P
V
V
L
I
L
D
E
P
T
S
A
L
D
V
L
T
Q
A
H
I
I
Q
L
L
K
E
L
K
K
M
L
K
I
T
L
I
F
V
T
H
D
I
A
V
A
A
E
L
A
D
K
V
A
V
I
Y
G
G
N
L
V
E
Y
N
S
T
F
Q
I
F
K
N
P
L
H
P
Y
T
R
G
L
I
N
S
I
M
----------
P
I
-----
P
G
D
P
P
S
L
L
N
P
P
S
G
C
R
F
H
P
R
C
E
Y
A
M
E
I
C
K
K
E
K
P
K
W
I
R
L
D
G
E
A
H
V
A
C
H
L
Y
E
E
-----------------------------
1
PsiBlast_PDB
84.93
39%
-82
- C1 -
-
4FWI
2
?
B:
[2-302]
-----
S
I
I
I
R
V
E
D
L
R
A
V
Y
L
V
R
E
G
T
I
K
A
A
D
G
I
S
L
D
I
L
E
N
S
V
T
A
I
V
G
E
S
A
S
G
K
S
T
I
I
E
A
M
T
K
T
-
L
P
P
N
G
R
I
L
S
G
R
V
L
Y
K
G
K
D
L
L
--
T
M
R
E
-
E
E
L
R
K
I
R
W
K
E
I
A
L
V
P
Q
A
A
Q
----
Q
S
L
N
P
T
-
M
K
V
--
I
E
H
F
K
D
T
V
E
A
H
----
G
V
-
R
W
S
H
S
E
-
L
I
E
K
A
S
E
K
L
R
M
V
R
-
L
-
N
P
E
A
V
L
N
----
S
Y
P
L
Q
L
S
G
G
M
K
Q
R
V
L
I
A
L
A
L
L
L
D
P
V
V
L
I
L
D
E
P
T
S
A
L
D
V
L
T
Q
A
H
I
I
Q
L
L
K
E
L
K
K
M
L
K
I
T
L
I
F
V
T
H
D
I
A
V
A
A
E
L
A
D
K
V
A
V
I
Y
G
G
N
L
V
E
Y
N
S
T
F
Q
I
F
K
N
P
L
H
P
Y
T
R
G
L
I
N
S
I
M
----------
P
I
-----
P
G
D
P
P
S
L
L
N
P
P
S
G
C
R
F
H
P
R
C
E
Y
A
M
E
I
C
K
K
E
K
------------------------------------------------
91
Fugue
78.82
26%
-122
- C1 -
-
3TUZ
1
METN_ECOLI
H:
[23-362]
------
H
M
I
K
L
S
N
I
T
K
V
F
H
Q
G
T
R
T
I
Q
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
-----
E
R
P
T
E
G
S
V
L
V
D
G
Q
E
L
T
--
T
L
S
-
E
S
E
L
T
K
A
R
R
Q
-
I
G
M
I
F
Q
H
F
------
N
L
L
S
S
-
R
T
V
--
F
G
N
V
A
L
P
L
E
L
D
-----
N
-
T
-
P
K
D
E
-
V
K
R
R
V
T
E
L
L
S
L
V
G
-
L
G
D
---
K
H
D
----
S
Y
P
S
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
L
E
L
L
K
D
I
N
R
R
L
G
L
T
I
L
L
I
T
H
E
M
D
V
V
K
R
I
C
D
C
V
A
V
I
S
N
G
E
L
I
E
Q
D
T
V
S
E
V
F
S
H
P
K
T
P
L
A
Q
K
F
I
Q
S
T
L
H
L
D
I
P
E
D
Y
Q
E
R
L
QAEPF
T
D
C
V
P
M
L
R
L
E
F
T
G
Q
S
V
D
A
P
L
L
S
E
T
A
R
R
F
N
V
N
N
N
I
I
S
A
Q
M
D
Y
A
G
G
V
K
F
G
I
M
L
T
E
M
H
G
T
Q
Q
D
T
Q
A
A
I
A
W
L
Q
E
H
H
V
K
V
E
V
--
102
HHSearch
77.50
32%
-147
- C1 -
-
3TUI
1
METN_ECOLI
C:
[23-269]
------
H
M
I
K
L
S
N
I
T
K
V
F
H
Q
G
T
R
T
I
Q
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
-
E
R
P
T
----
E
G
S
V
L
V
D
G
Q
E
L
T
--
T
L
S
-
E
S
E
L
T
K
A
R
-
R
Q
I
G
M
I
F
Q
H
F
------
N
L
L
S
S
-
R
T
V
--
F
G
N
V
A
L
P
L
E
L
D
----
N
--
T
-
P
K
D
E
-
V
K
R
R
V
T
E
L
L
S
L
V
G
-
L
G
D
---
K
H
D
----
S
Y
P
S
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
L
E
L
L
K
D
I
N
R
R
L
G
L
T
I
L
L
I
T
H
E
M
D
V
V
K
R
I
C
D
C
V
A
V
I
S
N
G
E
L
I
E
Q
D
T
V
S
E
V
F
S
H
P
K
T
P
L
A
Q
K
F
I
Q
S
T
L
H
-----------------------------------------------------------------------------------------------
22
PsiBlast_CBE
76.93
36%
-137
- C1 -
-
4YMU
1
?
A:
[14-239]
------------------------
L
E
V
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
-
L
-
L
E
E
P
---
T
K
G
E
V
F
I
D
G
V
K
I
N
----
N
G
K
V
N
I
N
K
V
R
-
Q
K
V
G
M
V
F
Q
H
------
F
N
L
F
P
H
-
L
T
A
--
I
E
N
I
T
L
A
P
V
K
V
----
K
K
-
M
-
N
K
K
E
-
A
E
E
L
A
V
D
L
L
A
K
V
G
-
L
L
D
---
K
K
D
----
Q
Y
P
I
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
N
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
G
V
I
V
E
E
G
T
P
E
E
I
F
Y
R
A
K
N
E
R
T
R
E
F
L
S
K
I
-------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
75.68
33%
-157
- C1 -
-
3TUJ
-
METN_ECOLI
C:
[6-243]
------------
N
I
T
K
V
F
H
Q
G
T
R
T
I
Q
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
-
L
-
L
E
---
R
P
T
E
G
S
V
L
V
D
G
Q
E
L
T
--
T
L
S
E
S
E
L
T
K
A
R
R
--
Q
I
G
M
I
F
Q
H
------
F
N
L
L
S
S
-
R
T
V
--
F
G
N
V
A
-
L
P
L
E
L
----
D
N
-
T
-
P
K
D
E
-
V
K
R
R
V
T
E
L
L
S
L
V
G
-
L
G
D
---
K
H
D
----
S
Y
P
S
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
L
E
L
L
K
D
I
N
R
R
L
G
L
T
I
L
L
I
T
H
E
M
D
V
V
K
R
I
C
D
C
V
A
V
I
S
N
G
E
L
I
E
Q
D
T
V
S
E
V
F
S
H
P
K
T
P
L
A
Q
K
F
I
Q
S
--------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
75.56
36%
-133
- C1 -
-
4YMU
1
?
J:
[14-239]
------------------------
L
E
V
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
-
L
-
L
E
E
P
---
T
K
G
E
V
F
I
D
G
V
K
I
N
----
N
G
K
V
N
I
N
K
V
R
-
Q
K
V
G
M
V
F
Q
H
------
F
N
L
F
P
H
-
L
T
A
--
I
E
N
I
T
L
A
P
V
K
V
----
K
K
-
M
-
N
K
K
E
-
A
E
E
L
A
V
D
L
L
A
K
V
G
-
L
L
D
---
K
K
D
----
Q
Y
P
I
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
N
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
G
V
I
V
E
E
G
T
P
E
E
I
F
Y
R
A
K
N
E
R
T
R
E
F
L
S
K
I
-------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
75.49
36%
-137
- C1 -
-
4YMV
1
?
J:
[14-239]
------------------------
L
E
V
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
-
L
-
L
E
E
P
---
T
K
G
E
V
F
I
D
G
V
K
I
N
----
N
G
K
V
N
I
N
K
V
R
-
Q
K
V
G
M
V
F
Q
H
------
F
N
L
F
P
H
-
L
T
A
--
I
E
N
I
T
L
A
P
V
K
V
----
K
K
-
M
-
N
K
K
E
-
A
E
E
L
A
V
D
L
L
A
K
V
G
-
L
L
D
---
K
K
D
----
Q
Y
P
I
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
N
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
G
V
I
V
E
E
G
T
P
E
E
I
F
Y
R
A
K
N
E
R
T
R
E
F
L
S
K
I
-------------------------------------------------------------------------------------------------
34
PsiBlast_CBE
75.37
32%
-142
- C1 -
-
3C4J
2
?
B:
[37-262]
------------------------
L
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
-
L
-
L
E
D
---
F
D
E
G
E
I
I
I
D
G
I
N
L
K
--
A
K
D
T
--
N
L
N
K
V
R
-
E
E
V
G
M
V
F
Q
R
------
F
N
L
F
P
H
-
M
T
V
--
L
N
N
I
T
L
A
P
M
K
V
----
R
K
-
W
-
P
R
E
K
-
A
E
A
K
A
M
E
L
L
D
K
V
G
-
L
K
D
---
K
A
H
----
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
K
V
-------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
75.21
36%
-134
- C1 -
-
4YMT
-
?
J:
[14-239]
------------------------
L
E
V
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
-
L
-
L
E
E
P
---
T
K
G
E
V
F
I
D
G
V
K
I
N
----
N
G
K
V
N
I
N
K
V
R
-
Q
K
V
G
M
V
F
Q
H
------
F
N
L
F
P
H
-
L
T
A
--
I
E
N
I
T
L
A
P
V
K
V
----
K
K
-
M
-
N
K
K
E
-
A
E
E
L
A
V
D
L
L
A
K
V
G
-
L
L
D
---
K
K
D
----
Q
Y
P
I
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
N
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
G
V
I
V
E
E
G
T
P
E
E
I
F
Y
R
A
K
N
E
R
T
R
E
F
L
S
K
I
-------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
75.14
36%
-134
- C1 -
-
4YMW
-
?
J:
[14-239]
------------------------
L
E
V
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
-
L
-
L
E
E
P
---
T
K
G
E
V
F
I
D
G
V
K
I
N
----
N
G
K
V
N
I
N
K
V
R
-
Q
K
V
G
M
V
F
Q
H
------
F
N
L
F
P
H
-
L
T
A
--
I
E
N
I
T
L
A
P
V
K
V
----
K
K
-
M
-
N
K
K
E
-
A
E
E
L
A
V
D
L
L
A
K
V
G
-
L
L
D
---
K
K
D
----
Q
Y
P
I
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
N
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
G
V
I
V
E
E
G
T
P
E
E
I
F
Y
R
A
K
N
E
R
T
R
E
F
L
S
K
I
-------------------------------------------------------------------------------------------------
101
HHSearch
75.08
33%
-154
- C1 -
-
3DHW
-
METN_ECOLI
C:
[1-246]
-------
M
I
K
L
S
N
I
T
K
V
F
H
Q
G
T
R
T
I
Q
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
-
E
R
P
T
----
E
G
S
V
L
V
D
G
Q
E
L
T
--
T
L
S
-
E
S
E
L
T
K
A
R
-
R
Q
I
G
M
I
F
Q
H
F
N
------
L
L
S
S
-
R
T
V
--
F
G
N
V
A
L
P
L
E
L
D
----
N
--
T
-
P
K
D
E
-
V
K
R
R
V
T
E
L
L
S
L
V
G
-
L
G
D
---
K
H
D
----
S
Y
P
S
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
E
A
T
S
A
L
D
P
A
T
T
R
S
I
L
E
L
L
K
D
I
N
R
R
L
G
L
T
I
L
L
I
T
H
E
M
D
V
V
K
R
I
C
D
C
V
A
V
I
S
N
G
E
L
I
E
Q
D
T
V
S
E
V
F
S
H
P
K
T
P
L
A
Q
K
F
I
Q
S
T
L
H
-----------------------------------------------------------------------------------------------
15
PsiBlast_PDB
75.06
32%
-142
- C1 -
-
2OLJ
3
?
A:
[37-262]
------------------------
L
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
-
L
-
L
E
D
---
F
D
E
G
E
I
I
I
D
G
I
N
L
K
--
A
K
D
T
--
N
L
N
K
V
R
-
E
E
V
G
M
V
F
Q
R
------
F
N
L
F
P
H
-
M
T
V
--
L
N
N
I
T
L
A
P
M
K
V
----
R
K
-
W
-
P
R
E
K
-
A
E
A
K
A
M
E
L
L
D
K
V
G
-
L
K
D
---
K
A
H
----
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
K
V
-------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
74.91
36%
-135
- C1 -
-
4YMS
-
?
J:
[14-239]
------------------------
L
E
V
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
-
L
-
L
E
E
P
---
T
K
G
E
V
F
I
D
G
V
K
I
N
----
N
G
K
V
N
I
N
K
V
R
-
Q
K
V
G
M
V
F
Q
H
------
F
N
L
F
P
H
-
L
T
A
--
I
E
N
I
T
L
A
P
V
K
V
----
K
K
-
M
-
N
K
K
E
-
A
E
E
L
A
V
D
L
L
A
K
V
G
-
L
L
D
---
K
K
D
----
Q
Y
P
I
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
N
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
G
V
I
V
E
E
G
T
P
E
E
I
F
Y
R
A
K
N
E
R
T
R
E
F
L
S
K
I
-------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
74.66
34%
-149
- C1 -
-
3TUZ
1
METN_ECOLI
C:
[39-266]
----------------------
R
T
I
Q
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
-
V
N
L
-
L
E
---
R
P
T
E
G
S
V
L
V
D
G
Q
E
L
T
--
T
L
S
E
S
E
L
T
K
A
R
R
--
Q
I
G
M
I
F
Q
H
------
F
N
L
L
S
S
-
R
T
V
--
F
G
N
V
A
-
L
P
L
E
L
----
D
N
-
T
-
P
K
D
E
-
V
K
R
R
V
T
E
L
L
S
L
V
G
-
L
G
D
---
K
H
D
----
S
Y
P
S
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
L
E
L
L
K
D
I
N
R
R
L
G
L
T
I
L
L
I
T
H
E
M
D
V
V
K
R
I
C
D
C
V
A
V
I
S
N
G
E
L
I
E
Q
D
T
V
S
E
V
F
S
H
P
K
T
P
L
A
Q
K
F
I
Q
S
--------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
74.57
32%
-137
- C1 -
-
2Q0H
3
?
A:
[37-262]
------------------------
L
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
-
L
-
L
E
D
---
F
D
E
G
E
I
I
I
D
G
I
N
L
K
--
A
K
D
T
--
N
L
N
K
V
R
-
E
E
V
G
M
V
F
Q
R
------
F
N
L
F
P
H
-
M
T
V
--
L
N
N
I
T
L
A
P
M
K
V
----
R
K
-
W
-
P
R
E
K
-
A
E
A
K
A
M
E
L
L
D
K
V
G
-
L
K
D
---
K
A
H
----
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
K
V
-------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
74.51
32%
-142
- C1 -
-
2OLK
1
?
A:
[37-262]
------------------------
L
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
-
L
-
L
E
D
---
F
D
E
G
E
I
I
I
D
G
I
N
L
K
--
A
K
D
T
--
N
L
N
K
V
R
-
E
E
V
G
M
V
F
Q
R
------
F
N
L
F
P
H
-
M
T
V
--
L
N
N
I
T
L
A
P
M
K
V
----
R
K
-
W
-
P
R
E
K
-
A
E
A
K
A
M
E
L
L
D
K
V
G
-
L
K
D
---
K
A
H
----
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
K
V
-------------------------------------------------------------------------------------------------
40
PsiBlast_CBE
74.44
32%
-141
- C1 -
-
2OLK
1
?
C:
[37-262]
------------------------
L
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
-
L
-
L
E
D
---
F
D
E
G
E
I
I
I
D
G
I
N
L
K
--
A
K
D
T
--
N
L
N
K
V
R
-
E
E
V
G
M
V
F
Q
R
------
F
N
L
F
P
H
-
M
T
V
--
L
N
N
I
T
L
A
P
M
K
V
----
R
K
-
W
-
P
R
E
K
-
A
E
A
K
A
M
E
L
L
D
K
V
G
-
L
K
D
---
K
A
H
----
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
K
V
-------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
74.28
32%
-142
- C1 -
-
2OUK
-
?
A:
[37-262]
------------------------
L
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
-
L
-
L
E
D
---
F
D
E
G
E
I
I
I
D
G
I
N
L
K
--
A
K
D
T
--
N
L
N
K
V
R
-
E
E
V
G
M
V
F
Q
R
------
F
N
L
F
P
H
-
M
T
V
--
L
N
N
I
T
L
A
P
M
K
V
----
R
K
-
W
-
P
R
E
K
-
A
E
A
K
A
M
E
L
L
D
K
V
G
-
L
K
D
---
K
A
H
----
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
K
V
-------------------------------------------------------------------------------------------------
21
PsiBlast_CBE
74.27
36%
-131
- C1 -
-
4YMV
1
?
A:
[14-239]
------------------------
L
E
V
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
-
L
-
L
E
E
P
---
T
K
G
E
V
F
I
D
G
V
K
I
N
----
N
G
K
V
N
I
N
K
V
R
-
Q
K
V
G
M
V
F
Q
H
------
F
N
L
F
P
H
-
L
T
A
--
I
E
N
I
T
L
A
P
V
K
V
----
K
K
-
M
-
N
K
K
E
-
A
E
E
L
A
V
D
L
L
A
K
V
G
-
L
L
D
---
K
K
D
----
Q
Y
P
I
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
N
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
G
V
I
V
E
E
G
T
P
E
E
I
F
Y
R
A
K
N
E
R
T
R
E
F
L
S
K
I
-------------------------------------------------------------------------------------------------
68
PsiBlast_CBE
49.62
32%
-31
- C1 -
-
4AYW
1
ABCBA_HUMAN
A:
[395-598]
-------------------------------
S
L
S
I
P
S
G
S
V
T
A
L
V
G
P
S
G
S
G
K
S
T
V
L
S
L
L
L
R
L
-
Y
D
P
----
A
S
G
T
I
S
L
D
G
H
D
I
R
--
Q
L
--
N
P
V
W
L
R
---
S
K
I
G
T
V
S
Q
E
P
I
----
L
F
---
S
-
C
S
I
--
A
E
N
I
A
Y
G
A
D
D
P
----
S
S
-
V
-
T
A
E
E
-
I
Q
R
V
A
-
E
V
A
N
A
V
A
F
I
R
N
F
P
Q
G
F
N
T
V
V
G
E
K
G
V
L
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
L
K
N
P
K
I
L
L
L
D
E
----
L
D
A
E
N
E
Y
L
V
Q
E
A
L
D
R
L
M
D
G
R
--
T
V
L
V
I
A
H
H
L
S
T
I
K
N
-
A
N
M
V
A
V
L
D
Q
G
K
I
T
E
Y
G
K
H
E
E
------------------------------------------------------------------------------------------------------------------
70
PsiBlast_CBE
49.60
32%
-32
- C1 -
-
4AYT
1
ABCBA_HUMAN
A:
[364-567]
-------------------------------
S
L
S
I
P
S
G
S
V
T
A
L
V
G
P
S
G
S
G
K
S
T
V
L
S
L
L
L
R
L
-
Y
D
P
----
A
S
G
T
I
S
L
D
G
H
D
I
R
--
Q
L
--
N
P
V
W
L
R
---
S
K
I
G
T
V
S
Q
E
P
I
----
L
--------
F
--
S
C
S
I
A
E
N
I
A
Y
G
ADDP
S
S
-
V
-
T
A
E
E
-
I
Q
R
V
A
-
E
V
A
N
A
V
A
F
I
R
N
F
P
Q
G
F
N
TVVG
E
K
G
V
L
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
L
K
N
P
K
I
L
L
L
D
E
A
T
S
A
L
D
A
E
N
E
Y
L
V
Q
E
A
L
D
R
L
M
D
G
R
--
T
V
L
V
I
A
H
R
L
S
T
I
K
N
-
A
N
M
V
A
V
L
D
Q
G
K
I
T
E
Y
G
K
H
E
E
------------------------------------------------------------------------------------------------------------------
69
PsiBlast_CBE
48.72
32%
-26
- C1 -
-
4AYX
1
ABCBA_HUMAN
A:
[364-574]
-------------------------------
S
L
S
I
P
S
G
S
V
T
A
L
V
G
P
S
G
S
G
K
S
T
V
L
S
L
L
L
R
L
-
Y
D
P
----
A
S
G
T
I
S
L
D
G
H
D
I
R
--
Q
L
--
N
P
V
W
L
R
---
S
K
I
G
T
V
S
Q
E
P
I
----
L
--------
F
--
S
C
S
I
A
E
N
I
A
Y
G
ADDP
S
S
-
V
-
T
A
E
E
-
I
Q
R
V
A
-
E
V
A
N
A
V
A
F
I
R
N
F
P
Q
G
F
N
T
V
V
G
E
K
G
V
L
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
L
K
N
P
K
I
L
L
L
D
E
A
T
S
A
L
D
A
E
N
E
Y
L
V
Q
E
A
L
D
R
L
M
D
G
R
--
T
V
L
V
I
A
H
R
L
S
T
I
K
N
-
A
N
M
V
A
V
L
D
Q
G
K
I
T
E
Y
G
K
H
E
E
L
L
S
K
P
N
G
-----------------------------------------------------------------------------------------------------------
45
PsiBlast_CBE
46.73
34%
-49
- C1 -
-
2PMK
1
A:
[24-243]
------------------------------
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
N
G
Q
V
L
---
I
D
--
G
H
D
L
---
A
L
A
D
-
P
N
W
L
R
---
R
Q
V
G
V
V
L
Q
D
N
V
LLNR
S
I
I
D
N
I
-
S
L
A
NP
G
M
S
V
E
K
V
I
Y
A
A
----
K
L
-
A
-
G
A
H
D
F
I
S
E
L
R
E
G
Y
N
T
I
V
G
--------------
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
K
G
R
--
T
V
I
I
I
A
H
R
L
S
T
V
K
N
-
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
P
E
-----
S
L
Y
S
Y
L
Y
Q
L
Q
S
D
-------------------------------------------------------------------------------------------
79
PsiBlast_CBE
45.52
32%
-
- C1 -
-
3B5Z
2
MSBA_SALTY
A:
[347-566]
---------------
V
T
F
T
Y
P
G
R
E
V
P
A
L
R
N
I
N
L
K
I
P
A
G
K
T
V
A
L
V
G
R
S
G
S
G
K
S
T
I
A
S
L
I
T
R
F
-
Y
D
----
I
D
E
G
H
I
L
M
D
G
H
D
L
R
EY
T
L
A
S
L
R
N
-------
Q
V
A
L
V
S
Q
N
V
H
----
L
F
N
D
T
V
A
N
N
I
--
A
Y
A
R
T
E
E
Y
S
R
E
----
Q
I
-
E
-
E
A
A
R
-
M
A
-
Y
A
M
D
F
I
N
K
M
D
--
N
G
L
D
T
I
I
G
----
E
N
G
V
L
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
L
R
D
S
P
I
L
I
L
D
E
A
T
S
A
L
D
T
E
S
E
R
A
I
Q
A
A
L
D
E
L
Q
K
N
R
--
T
S
L
V
I
A
H
R
L
S
T
I
E
Q
-
A
D
E
I
V
V
V
E
D
G
I
I
V
E
R
G
T
H
S
E
L
L
----------------------------------------------------------------------------------------------------------------
77
PsiBlast_CBE
45.52
32%
-
- C1 -
-
3B5Z
2
MSBA_SALTY
C:
[347-566]
---------------
V
T
F
T
Y
P
G
R
E
V
P
A
L
R
N
I
N
L
K
I
P
A
G
K
T
V
A
L
V
G
R
S
G
S
G
K
S
T
I
A
S
L
I
T
R
F
-
Y
D
----
I
D
E
G
H
I
L
M
D
G
H
D
L
R
EY
T
L
A
S
L
R
N
-------
Q
V
A
L
V
S
Q
N
V
H
----
L
F
N
D
T
V
A
N
N
I
--
A
Y
A
R
T
E
E
Y
S
R
E
----
Q
I
-
E
-
E
A
A
R
-
M
A
-
Y
A
M
D
F
I
N
K
M
D
--
N
G
L
D
T
I
I
G
----
E
N
G
V
L
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
L
R
D
S
P
I
L
I
L
D
E
A
T
S
A
L
D
T
E
S
E
R
A
I
Q
A
A
L
D
E
L
Q
K
N
R
--
T
S
L
V
I
A
H
R
L
S
T
I
E
Q
-
A
D
E
I
V
V
V
E
D
G
I
I
V
E
R
G
T
H
S
E
L
L
----------------------------------------------------------------------------------------------------------------
82
PsiBlast_CBE
45.15
32%
-
- C1 -
-
3B5Y
2
MSBA_SALTY
B:
[347-566]
---------------
V
T
F
T
Y
P
G
R
E
V
P
A
L
R
N
I
N
L
K
I
P
A
G
K
T
V
A
L
V
G
R
S
G
S
G
K
S
T
I
A
S
L
I
T
R
F
-
Y
D
----
I
D
E
G
H
I
L
M
D
G
H
D
L
R
EY
T
L
A
S
L
R
N
-------
Q
V
A
L
V
S
Q
N
V
H
----
L
F
N
D
T
V
A
N
N
I
--
A
Y
A
R
T
E
E
Y
S
R
E
----
Q
I
-
E
-
E
A
A
R
-
M
A
-
Y
A
M
D
F
I
N
K
M
D
--
N
G
L
D
T
I
I
G
----
E
N
G
V
L
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
L
R
D
S
P
I
L
I
L
D
E
A
T
S
A
L
D
T
E
S
E
R
A
I
Q
A
A
L
D
E
L
Q
K
N
R
--
T
S
L
V
I
A
H
R
L
S
T
I
E
Q
-
A
D
E
I
V
V
V
E
D
G
I
I
V
E
R
G
T
H
S
E
L
L
----------------------------------------------------------------------------------------------------------------
81
PsiBlast_CBE
45.12
32%
-
- C1 -
-
3B5Y
2
MSBA_SALTY
C:
[347-566]
---------------
V
T
F
T
Y
P
G
R
E
V
P
A
L
R
N
I
N
L
K
I
P
A
G
K
T
V
A
L
V
G
R
S
G
S
G
K
S
T
I
A
S
L
I
T
R
F
-
Y
D
----
I
D
E
G
H
I
L
M
D
G
H
D
L
R
EY
T
L
A
S
L
R
N
-------
Q
V
A
L
V
S
Q
N
V
H
----
L
F
N
D
T
V
A
N
N
I
--
A
Y
A
R
T
E
E
Y
S
R
E
----
Q
I
-
E
-
E
A
A
R
-
M
A
-
Y
A
M
D
F
I
N
K
M
D
--
N
G
L
D
T
I
I
G
----
E
N
G
V
L
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
L
R
D
S
P
I
L
I
L
D
E
A
T
S
A
L
D
T
E
S
E
R
A
I
Q
A
A
L
D
E
L
Q
K
N
R
--
T
S
L
V
I
A
H
R
L
S
T
I
E
Q
-
A
D
E
I
V
V
V
E
D
G
I
I
V
E
R
G
T
H
S
E
L
L
----------------------------------------------------------------------------------------------------------------
80
PsiBlast_CBE
45.12
32%
-
- C1 -
-
3B5Y
2
MSBA_SALTY
D:
[347-566]
---------------
V
T
F
T
Y
P
G
R
E
V
P
A
L
R
N
I
N
L
K
I
P
A
G
K
T
V
A
L
V
G
R
S
G
S
G
K
S
T
I
A
S
L
I
T
R
F
-
Y
D
----
I
D
E
G
H
I
L
M
D
G
H
D
L
R
EY
T
L
A
S
L
R
N
-------
Q
V
A
L
V
S
Q
N
V
H
----
L
F
N
D
T
V
A
N
N
I
--
A
Y
A
R
T
E
E
Y
S
R
E
----
Q
I
-
E
-
E
A
A
R
-
M
A
-
Y
A
M
D
F
I
N
K
M
D
--
N
G
L
D
T
I
I
G
----
E
N
G
V
L
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
L
R
D
S
P
I
L
I
L
D
E
A
T
S
A
L
D
T
E
S
E
R
A
I
Q
A
A
L
D
E
L
Q
K
N
R
--
T
S
L
V
I
A
H
R
L
S
T
I
E
Q
-
A
D
E
I
V
V
V
E
D
G
I
I
V
E
R
G
T
H
S
E
L
L
----------------------------------------------------------------------------------------------------------------
48
PsiBlast_CBE
44.98
34%
-51
- C1 -
-
3B5J
1
A:
[24-243]
------------------------------
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
A
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
N
G
Q
V
L
---
I
D
--
G
H
D
L
---
A
L
A
D
-
P
N
W
L
R
---
R
Q
V
G
V
V
L
Q
D
N
V
LLNR
S
I
I
D
N
I
-
S
L
A
NP
G
M
S
V
E
K
V
I
Y
A
A
----
K
L
-
A
-
G
A
H
D
F
I
S
E
L
R
E
G
Y
N
T
I
V
G
--------------
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
K
G
R
--
T
V
I
I
I
A
H
R
L
S
T
V
K
N
-
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
P
E
-----
S
L
Y
S
Y
L
Y
Q
L
Q
S
D
-------------------------------------------------------------------------------------------
63
PsiBlast_CBE
44.14
32%
-50
- C1 -
-
2FFA
2
A:
[28-240]
------------------------------
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
N
G
Q
V
L
---
I
D
--
G
H
D
L
A
--
L
--
A
D
P
N
W
L
R
---
R
Q
V
G
V
V
L
Q
D
N
V
LLNR
S
I
I
D
N
I
-
S
L
A
NP
G
M
S
V
E
K
V
I
Y
A
A
----
K
L
-
A
-
G
A
H
D
F
I
S
E
L
R
E
G
Y
N
T
I
V
G
--------------
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
K
G
R
--
T
V
I
I
I
A
A
R
L
S
T
V
K
N
-
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
P
E
S
L
Y
S
Y
-------------------------------------------------------------------------------------------------------
46
PsiBlast_CBE
44.03
32%
-51
- C1 -
-
2FF7
1
A:
[28-240]
------------------------------
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
N
G
Q
V
L
---
I
D
--
G
H
D
L
A
--
L
--
A
D
P
N
W
L
R
---
R
Q
V
G
V
V
L
Q
D
N
V
LLNR
S
I
I
D
N
I
-
S
L
A
NP
G
M
S
V
E
K
V
I
Y
A
A
----
K
L
-
A
-
G
A
H
D
F
I
S
E
L
R
E
G
Y
N
T
I
V
G
--------------
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
K
G
R
--
T
V
I
I
I
A
H
R
L
S
T
V
K
N
-
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
P
E
S
L
Y
S
Y
-------------------------------------------------------------------------------------------------------
61
PsiBlast_CBE
43.81
32%
-37
- C1 -
-
2FGJ
2
HLYBP_ECOLX
B:
[28-240]
------------------------------
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
N
G
Q
V
L
---
I
D
--
G
H
D
L
A
--
L
--
A
D
P
N
W
L
R
---
R
Q
V
G
V
V
L
Q
D
N
V
LLNR
S
I
I
D
N
I
-
S
L
A
NP
G
M
S
V
E
K
V
I
Y
A
A
----
K
L
-
A
-
G
A
H
D
F
I
S
E
L
R
E
G
Y
N
T
I
V
G
--------------
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
K
G
R
--
T
V
I
I
I
A
A
R
L
S
T
V
K
N
-
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
P
E
S
L
Y
S
Y
-------------------------------------------------------------------------------------------------------
59
PsiBlast_CBE
43.38
32%
-46
- C1 -
-
2FGJ
2
D:
[28-240]
------------------------------
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
N
G
Q
V
L
---
I
D
--
G
H
D
L
A
--
L
--
A
D
P
N
W
L
R
---
R
Q
V
G
V
V
L
Q
D
N
V
LLNR
S
I
I
D
N
I
-
S
L
A
NP
G
M
S
V
E
K
V
I
Y
A
A
----
K
L
-
A
-
G
A
H
D
F
I
S
E
L
R
E
G
Y
N
T
I
V
G
--------------
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
K
G
R
--
T
V
I
I
I
A
A
R
L
S
T
V
K
N
-
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
P
E
S
L
Y
S
Y
-------------------------------------------------------------------------------------------------------
64
PsiBlast_CBE
43.30
32%
-38
- C1 -
-
1XEF
2
D:
[22-234]
------------------------------
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
N
G
Q
V
L
---
I
D
--
G
H
D
L
A
--
L
--
A
D
P
N
W
L
R
---
R
Q
V
G
V
V
L
Q
D
N
V
LLNR
S
I
I
D
N
I
-
S
L
A
NP
G
M
S
V
E
K
V
I
Y
A
A
----
K
L
-
A
-
G
A
H
D
F
I
S
E
L
R
E
G
Y
N
T
I
V
G
--------------
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
K
G
R
--
T
V
I
I
I
A
A
R
L
S
T
V
K
N
-
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
P
E
S
L
Y
S
Y
-------------------------------------------------------------------------------------------------------
53
PsiBlast_CBE
43.27
32%
-52
- C1 -
-
2FFB
1
A:
[28-240]
------------------------------
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
N
G
Q
V
L
---
I
D
--
G
H
D
L
A
--
L
--
A
D
P
N
W
L
R
---
R
Q
V
G
V
V
L
Q
D
N
V
LLNR
S
I
I
D
N
I
-
S
L
A
NP
G
M
S
V
E
K
V
I
Y
A
A
----
K
L
-
A
-
G
A
H
D
F
I
S
E
L
R
E
G
Y
N
T
I
V
G
--------------
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
Q
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
K
G
R
--
T
V
I
I
I
A
H
R
L
S
T
V
K
N
-
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
P
E
S
L
Y
S
Y
-------------------------------------------------------------------------------------------------------
50
PsiBlast_CBE
42.96
32%
-43
- C1 -
-
2FGK
2
HLYBP_ECOLX
C:
[28-240]
------------------------------
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
N
G
Q
V
L
---
I
D
--
G
H
D
L
A
--
L
--
A
D
P
N
W
L
R
---
R
Q
V
G
V
V
L
Q
D
N
V
LLNR
S
I
I
D
N
I
-
S
L
A
NP
G
M
S
V
E
K
V
I
Y
A
A
----
K
L
-
A
-
G
A
H
D
F
I
S
E
L
R
E
G
Y
N
T
I
V
G
--------------
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
Q
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
K
G
R
--
T
V
I
I
I
A
H
R
L
S
T
V
K
N
-
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
P
E
S
L
Y
S
Y
-------------------------------------------------------------------------------------------------------
66
PsiBlast_CBE
42.79
32%
-40
- C1 -
-
1XEF
2
HLYBP_ECOLX
B:
[22-234]
------------------------------
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
N
G
Q
V
L
---
I
D
--
G
H
D
L
A
--
L
--
A
D
P
N
W
L
R
---
R
Q
V
G
V
V
L
Q
D
N
V
LLNR
S
I
I
D
N
I
-
S
L
A
NP
G
M
S
V
E
K
V
I
Y
A
A
----
K
L
-
A
-
G
A
H
D
F
I
S
E
L
R
E
G
Y
N
T
I
V
G
--------------
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
K
G
R
--
T
V
I
I
I
A
A
R
L
S
T
V
K
N
-
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
P
E
S
L
Y
S
Y
-------------------------------------------------------------------------------------------------------
65
PsiBlast_CBE
42.62
32%
-34
- C1 -
-
1XEF
2
HLYBP_ECOLX
C:
[22-234]
------------------------------
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
N
G
Q
V
L
---
I
D
--
G
H
D
L
A
--
L
--
A
D
P
N
W
L
R
---
R
Q
V
G
V
V
L
Q
D
N
V
LLNR
S
I
I
D
N
I
-
S
L
A
NP
G
M
S
V
E
K
V
I
Y
A
A
----
K
L
-
A
-
G
A
H
D
F
I
S
E
L
R
E
G
Y
N
T
I
V
G
--------------
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
K
G
R
--
T
V
I
I
I
A
A
R
L
S
T
V
K
N
-
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
P
E
S
L
Y
S
Y
-------------------------------------------------------------------------------------------------------
52
PsiBlast_CBE
42.62
32%
-43
- C1 -
-
2FGK
2
HLYBP_ECOLX
A:
[28-240]
------------------------------
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
N
G
Q
V
L
---
I
D
--
G
H
D
L
A
--
L
--
A
D
P
N
W
L
R
---
R
Q
V
G
V
V
L
Q
D
N
V
LLNR
S
I
I
D
N
I
-
S
L
A
NP
G
M
S
V
E
K
V
I
Y
A
A
----
K
L
-
A
-
G
A
H
D
F
I
S
E
L
R
E
G
Y
N
T
I
V
G
--------------
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
Q
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
K
G
R
--
T
V
I
I
I
A
H
R
L
S
T
V
K
N
-
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
P
E
S
L
Y
S
Y
-------------------------------------------------------------------------------------------------------
62
PsiBlast_CBE
42.04
32%
-37
- C1 -
-
2FGJ
2
HLYBP_ECOLX
A:
[28-240]
------------------------------
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
N
G
Q
V
L
---
I
D
--
G
H
D
L
A
--
L
--
A
D
P
N
W
L
R
---
R
Q
V
G
V
V
L
Q
D
N
V
L
L
NR
S
I
I
D
N
I
-
S
L
A
NP
G
M
S
V
E
K
V
I
Y
A
A
----
K
L
-
A
-
G
A
H
D
F
I
S
E
L
R
E
G
Y
N
T
I
V
G
--------------
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
K
G
R
--
T
V
I
I
I
A
A
R
L
S
T
V
K
N
-
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
P
E
S
L
Y
S
Y
-------------------------------------------------------------------------------------------------------
49
PsiBlast_CBE
42.03
32%
-44
- C1 -
-
2FGK
2
D:
[28-240]
------------------------------
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
N
G
Q
V
L
---
I
D
--
G
H
D
L
A
--
L
--
A
D
P
N
W
L
R
---
R
Q
V
G
V
V
L
Q
D
N
V
LLNR
S
I
I
D
N
I
-
S
L
A
NP
G
M
S
V
E
K
V
I
Y
A
A
----
K
L
-
A
-
G
A
H
D
F
I
S
E
L
R
E
G
Y
N
T
I
V
G
--------------
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
Q
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
K
G
R
--
T
V
I
I
I
A
H
R
L
S
T
V
K
N
-
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
P
E
S
L
Y
S
Y
-------------------------------------------------------------------------------------------------------
51
PsiBlast_CBE
41.93
32%
-44
- C1 -
-
2FGK
2
HLYBP_ECOLX
B:
[28-240]
------------------------------
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
N
G
Q
V
L
---
I
D
--
G
H
D
L
A
--
L
--
A
D
P
N
W
L
R
---
R
Q
V
G
V
V
L
Q
D
N
V
LLNR
S
I
I
D
N
I
-
S
L
A
NP
G
M
S
V
E
K
V
I
Y
A
A
----
K
L
-
A
-
G
A
H
D
F
I
S
E
L
R
E
G
Y
N
T
I
V
G
--------------
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
Q
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
K
G
R
--
T
V
I
I
I
A
H
R
L
S
T
V
K
N
-
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
P
E
S
L
Y
S
Y
-------------------------------------------------------------------------------------------------------
67
PsiBlast_CBE
41.69
32%
-35
- C1 -
-
1XEF
2
HLYBP_ECOLX
A:
[22-234]
------------------------------
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
N
G
Q
V
L
---
I
D
--
G
H
D
L
A
--
L
--
A
D
P
N
W
L
R
---
R
Q
V
G
V
V
L
Q
D
N
V
L
L
NR
S
I
I
D
N
I
-
S
L
A
NP
G
M
S
V
E
K
V
I
Y
A
A
----
K
L
-
A
-
G
A
H
D
F
I
S
E
L
R
E
G
Y
N
T
I
V
G
--------------
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
K
G
R
--
T
V
I
I
I
A
A
R
L
S
T
V
K
N
-
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
P
E
S
L
Y
S
Y
-------------------------------------------------------------------------------------------------------
60
PsiBlast_CBE
41.13
32%
-35
- C1 -
-
2FGJ
2
HLYBP_ECOLX
C:
[28-240]
------------------------------
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
N
G
Q
V
L
---
I
D
--
G
H
D
L
A
--
L
--
A
D
P
N
W
L
R
---
R
Q
V
G
V
V
L
Q
D
N
V
LLNR
S
I
I
D
N
I
-
S
L
A
NP
G
M
S
V
E
K
V
I
Y
A
A
----
K
L
-
A
-
G
A
H
D
F
I
S
E
L
R
E
G
Y
N
T
I
V
G
--------------
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
K
G
R
--
T
V
I
I
I
A
A
R
L
S
T
V
K
N
-
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
P
E
S
L
Y
S
Y
-------------------------------------------------------------------------------------------------------