@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : spr1712: (2018-01-18 )
MEWYKKIGLLATTGLALFGLGACSNYGKSADGTVTIEYFNQKKEMTKTLEEITRDFEKENPKIKVKVVNVPNAGEVLKTRVLAGDVPDVVNIYPQSIELQEWAKAGVFEDLSNKDYLKRVKNGYAEKYAVNEKVYNVPFTANAYGIYYNKDKFEELGLKVPETWDEFEQLVKDIVAKGQTPFGIAGADAWTLNGYNQLAFATATGGGKEANQYLRYSQPNAIKLSDPIMKDDIKVMDILRINGSKQKNWEGAGYTDVIGAFARGDVLMTPNGSWAITAINEQKPNFKIGTFMIPGKEKGQSLTVGAGDLAWSISATTKHPKEANAFVEYMTRPEVMQKYYDVDGSPTAIEGVKQAGEDSPLAGMTEYAFTDRHLVWLQQYWTSEADFHTLTMNYVLTGDKEGMVNDLNAFFNPMKADVD
Atome Classification :
(20 SA)
.........10........20........30........40...--......50.......----.60........70..--..-----.....80........90.........100......----.110--------...---.------...120.......130---.........140...-.....150......---.-160.......170......---.180.......190.......200.......210.--......220...-.....230.......240.......250.--...-...260.......270........280---.---.---.....290.......300-.--.-..-...-..310.......320......-.-330.......340....-...350..-.-.---.---..360...-....370..-.-...----..380.-.-.....390......--.400.......410.......-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
M
E
W
Y
K
K
IG
L
L
A
TT
G
L
A
L
F
G
L
G
A
CSNYGKSAD
G
T
V
T
I
E
Y
F
N
-
Q
K
K
--
E
M
T
K
T
L
E
E
I
T
R
D
F
EK----ENP
K
I
K
V
K
V
V
NV-PN--A
G
-----
E
V
L
K
T
R
V
LAGDVP
D
V
V
-
N
IYPQSI
E
L
Q
E
W
A
KAG
V
F
----
E
DLS--------N
K
D
---
Y
------
L
K
R
V
K
NGYAE
K
Y
AV-----N
E
K
V
Y
NVPFT-A
N
A
Y
-
G
I
YYN
K
D
K
F
E
E
LGL---K-VPE
T
W
D
E
F
E
Q
L
V
K
D
I
V
AKG---QT
P
F
G
IAGA
D
A
W
T
LNGYN
Q
L
A
F
A
TATGG
G
K
E
A
N
Q
Y
--
L
RYSQP
N
-
A
I
KL-SDPIMKDD
I
K
V
M
D
I
L
RINGSKQKNWEGAG--
Y
T
D
-
V
I
G
A
FARG
D
V
L
MTPN-G
S
W
A
I
T
A
INEQ---K---P---N
F
K
I
G
T
F
M
IPGKEKG
Q
---
S
--
L
-
T
V-GAG-
D
L
A
W
S
ISATTKHP
K
E
A
N
A
F
V
E
-
Y
-MT
R
P
E
V
M
Q
K
Y
YDVDGS
P
-
T
A
I
E
G
V
K
Q-A-G---E---DSPLAGMT-EYAFTD-
R
H
-
L
-
V
W
L
----
Q
Q
Y
WTS-E-AD
F
H
T
L
T
M
N
Y
V
L
TG--DKEG
M
V
N
D
L
N
A
FFN
P
M
KADVD-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
99.40
99%
-75
- C1 -
-
2HQ0
-
?
A:
[5-387]
--------------------------------
T
V
T
I
E
Y
F
N
-
Q
K
K
--
E
M
T
K
T
L
E
E
I
T
R
D
F
E
K
----
E
N
P
-
I
K
V
K
V
V
N
V
-
P
N
--
A
G
-----
E
V
L
K
T
R
V
L
A
G
D
V
P
D
V
V
-
N
I
Y
P
Q
S
I
E
L
Q
E
W
A
K
A
G
V
F
----
E
D
L
S
--------
N
K
D
---
Y
------
L
K
R
V
K
N
G
Y
A
E
K
Y
A
V
-----
N
E
K
V
Y
N
V
P
F
T
-
A
N
A
Y
-
G
I
Y
Y
N
K
D
K
F
E
E
L
G
L
---
K
-
V
P
E
T
W
D
E
F
E
Q
L
V
K
D
I
V
A
K
G
---
Q
T
P
F
G
I
A
G
A
D
A
W
T
L
N
G
Y
N
Q
L
A
F
A
T
A
T
G
G
G
K
E
A
N
Q
Y
--
L
R
Y
S
Q
P
N
-
A
I
K
L
-
S
D
P
I
M
K
D
D
I
K
V
M
D
I
L
R
I
N
G
S
K
Q
K
N
W
E
G
A
G
--
Y
T
D
-
V
I
G
A
F
A
R
G
D
V
L
M
T
P
N
-
G
S
W
A
I
T
A
I
N
E
Q
---
K
---
P
---
N
F
K
I
G
T
F
M
I
P
G
K
E
K
G
Q
---
S
--
L
-
T
V
-
G
A
G
-
D
L
A
W
S
I
S
A
T
T
K
H
P
K
E
A
N
A
F
V
E
-
Y
-
M
T
R
P
E
V
M
Q
K
Y
Y
D
V
D
G
S
P
-
T
A
I
E
G
V
K
Q
-
A
-
G
---
E
---
D
S
P
L
A
G
M
T
-
E
Y
A
F
T
D
-
R
H
-
L
-
V
W
L
----
Q
Q
Y
W
T
S
-
E
-
A
D
F
H
T
L
T
M
N
Y
V
L
T
G
--
D
K
Q
G
M
V
N
D
L
N
A
F
F
N
P
M
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
PsiBlast_CBE
99.25
99%
-75
- C1 -
-
2I58
1
?
B:
[5-387]
--------------------------------
T
V
T
I
E
Y
F
N
-
Q
K
K
--
E
M
T
K
T
L
E
E
I
T
R
D
F
E
K
----
E
N
P
K
I
K
V
K
V
V
N
V
-
P
N
--
A
G
-----
E
V
L
K
T
R
V
L
A
G
D
V
P
D
V
V
-
N
I
Y
P
Q
S
I
E
L
Q
E
W
A
K
A
G
V
F
----
E
D
L
S
--------
N
K
D
---
Y
------
L
K
R
V
K
N
G
Y
A
E
K
Y
A
V
-----
N
E
K
V
Y
N
V
P
F
T
-
A
N
A
Y
-
G
I
Y
Y
N
K
D
K
F
E
E
L
G
L
---
K
-
V
P
E
T
W
D
E
F
E
Q
L
V
K
D
I
V
A
K
G
---
Q
T
P
F
G
I
A
G
A
D
A
W
T
L
N
G
Y
N
Q
L
A
F
A
T
A
T
G
G
G
K
E
A
N
Q
Y
--
L
R
Y
S
Q
P
N
-
A
I
K
L
-
S
D
P
I
M
K
D
D
I
K
V
M
D
I
L
R
I
N
G
S
K
Q
K
N
W
E
G
A
G
--
Y
T
D
-
V
I
G
A
F
A
R
G
D
V
L
M
T
P
N
-
G
S
W
A
I
T
A
I
N
E
Q
---
K
---
P
---
N
F
K
I
G
T
F
M
I
P
G
K
E
K
G
Q
---
S
--
L
-
T
V
-
G
A
G
-
D
L
A
W
S
I
S
A
T
T
K
H
P
K
E
A
N
A
F
V
E
-
Y
-
M
T
R
P
E
V
M
Q
K
Y
Y
D
V
D
G
S
P
-
T
A
I
E
G
V
K
Q
-
A
-
G
---
E
---
D
S
P
L
A
G
M
T
-
E
Y
A
F
T
D
-
R
H
-
L
-
V
W
L
----
Q
Q
Y
W
T
S
-
E
-
A
D
F
H
T
L
T
M
N
Y
V
L
T
G
--
D
K
Q
G
M
V
N
D
L
N
A
F
F
N
P
M
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
97.57
99%
-68
- C1 -
-
2I58
1
?
A:
[5-387]
--------------------------------
T
V
T
I
E
Y
F
N
-
Q
K
K
--
E
M
T
K
T
L
E
E
I
T
R
D
F
E
K
----
E
N
P
K
I
K
V
K
V
V
N
V
-
P
N
--
A
G
-----
E
V
L
K
T
R
V
L
A
G
D
V
P
D
V
V
-
N
I
Y
P
Q
S
I
E
L
Q
E
W
A
K
A
G
V
F
----
E
D
L
S
--------
N
K
D
---
Y
------
L
K
R
V
K
N
G
Y
A
E
K
Y
A
V
-----
N
E
K
V
Y
N
V
P
F
T
-
A
N
A
Y
-
G
I
Y
Y
N
K
D
K
F
E
E
L
G
L
---
K
-
V
P
E
T
W
D
E
F
E
Q
L
V
K
D
I
V
A
K
G
---
Q
T
P
F
G
I
A
G
A
D
A
W
T
L
N
G
Y
N
Q
L
A
F
A
T
A
T
G
G
G
K
E
A
N
Q
Y
--
L
R
Y
S
Q
P
N
-
A
I
K
L
-
S
D
P
I
M
K
D
D
I
K
V
M
D
I
L
R
I
N
G
S
K
Q
K
N
W
E
G
A
G
--
Y
T
D
-
V
I
G
A
F
A
R
G
D
V
L
M
T
P
N
-
G
S
W
A
I
T
A
I
N
E
Q
---
K
---
P
---
N
F
K
I
G
T
F
M
I
P
G
K
E
K
G
Q
---
S
--
L
-
T
V
-
G
A
G
-
D
L
A
W
S
I
S
A
T
T
K
H
P
K
E
A
N
A
F
V
E
-
Y
-
M
T
R
P
E
V
M
Q
K
Y
Y
D
V
D
G
S
P
-
T
A
I
E
G
V
K
Q
-
A
-
G
---
E
---
D
S
P
L
A
G
M
T
-
E
Y
A
F
T
D
-
R
H
-
L
-
V
W
L
----
Q
Q
Y
W
T
S
-
E
-
A
D
F
H
T
L
T
M
N
Y
V
L
T
G
--
D
K
Q
G
M
V
N
D
L
N
A
F
F
N
P
M
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
97.29
99%
-75
- C1 -
-
2HEU
-
?
A:
[18-400]
--------------------------------
T
V
T
I
E
Y
F
N
-
Q
K
K
--
E
M
T
K
T
L
E
E
I
T
R
D
F
E
K
----
E
N
P
K
I
-
V
K
V
V
N
V
-
P
N
--
A
G
-----
E
V
L
K
T
R
V
L
A
G
D
V
P
D
V
V
-
N
I
Y
P
Q
S
I
E
L
Q
E
W
A
K
A
G
V
F
----
E
D
L
S
--------
N
K
D
---
Y
------
L
K
R
V
K
N
G
Y
A
E
K
Y
A
V
-----
N
E
K
V
Y
N
V
P
F
T
-
A
N
A
Y
-
G
I
Y
Y
N
K
D
K
F
E
E
L
G
L
---
K
-
V
P
E
T
W
D
E
F
E
Q
L
V
K
D
I
V
A
K
G
---
Q
T
P
F
G
I
A
G
A
D
A
W
T
L
N
G
Y
N
Q
L
A
F
A
T
A
T
G
G
G
K
E
A
N
Q
Y
--
L
R
Y
S
Q
P
N
-
A
I
K
L
-
S
D
P
I
M
K
D
D
I
K
V
M
D
I
L
R
I
N
G
S
K
Q
K
N
W
E
G
A
G
--
Y
T
D
-
V
I
G
A
F
A
R
G
D
V
L
M
T
P
N
-
G
S
W
A
I
T
A
I
N
E
Q
---
K
---
P
---
N
F
K
I
G
T
F
M
I
P
G
K
E
K
G
Q
---
S
--
L
-
T
V
-
G
A
G
-
D
L
A
W
S
I
S
A
T
T
K
H
P
K
E
A
N
A
F
V
E
-
Y
-
M
T
R
P
E
V
M
Q
K
Y
Y
D
V
D
G
S
P
-
T
A
I
E
G
V
K
Q
-
A
-
G
---
E
---
D
S
P
L
A
G
M
T
-
E
Y
A
F
T
D
-
R
H
-
L
-
V
W
L
----
Q
Q
Y
W
T
S
-
E
-
A
D
F
H
T
L
T
M
N
Y
V
L
T
G
--
D
K
Q
G
M
V
N
D
L
N
A
F
F
N
P
M
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
PsiBlast_CBE
97.16
99%
-73
- C1 -
-
2HEU
1
?
C:
[18-400]
--------------------------------
T
V
T
I
E
Y
F
N
-
Q
K
K
--
E
M
T
K
T
L
E
E
I
T
R
D
F
E
K
----
E
N
P
K
I
K
V
K
V
V
N
V
-
P
N
--
A
G
-----
E
V
L
K
T
R
V
L
A
G
D
V
P
D
V
V
-
N
I
Y
P
Q
S
I
E
L
Q
E
W
A
K
A
G
V
F
----
E
D
L
S
--------
N
K
D
---
Y
------
L
K
R
V
K
N
G
Y
A
E
K
Y
A
V
-----
N
E
K
V
Y
N
V
P
F
T
-
A
N
A
Y
-
G
I
Y
Y
N
K
D
K
F
E
E
L
G
L
---
K
-
V
P
E
T
W
D
E
F
E
Q
L
V
K
D
I
V
A
K
G
---
Q
T
P
F
G
I
A
G
A
D
A
W
T
L
N
G
Y
N
Q
L
A
F
A
T
A
T
G
G
G
K
E
A
N
Q
Y
--
L
R
Y
S
Q
P
N
-
A
I
K
L
-
S
D
P
I
M
K
D
D
I
K
V
M
D
I
L
R
I
N
G
S
K
Q
K
N
W
E
G
A
G
--
Y
T
D
-
V
I
G
A
F
A
R
G
D
V
L
M
T
P
N
-
G
S
W
A
I
T
A
I
N
E
Q
---
K
---
P
---
N
F
K
I
G
T
F
M
I
P
G
K
E
K
G
Q
---
S
--
L
-
T
V
-
G
A
G
-
D
L
A
W
S
I
S
A
T
T
K
H
P
K
E
A
N
A
F
V
E
-
Y
-
M
T
R
P
E
V
M
Q
K
Y
Y
D
V
D
G
S
P
-
T
A
I
E
G
V
K
Q
-
A
-
G
---
E
---
D
S
P
L
A
G
M
T
-
E
Y
A
F
T
D
-
R
H
-
L
-
V
W
L
----
Q
Q
Y
W
T
S
-
E
-
A
D
F
H
T
L
T
M
N
Y
V
L
T
G
--
D
K
Q
G
M
V
N
D
L
N
A
F
F
N
P
M
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
27
HHSearch
96.64
96%
-69
- C1 -
-
2HQ0
-
?
A:
[3-386]
------------------------------
S
S
T
V
T
I
E
Y
F
N
-
Q
K
K
--
E
M
T
K
T
L
E
E
I
T
R
D
F
E
K
----
E
N
P
-
I
K
V
K
V
V
N
V
-
P
N
--
A
G
-----
E
V
L
K
T
R
V
L
A
G
D
V
P
D
V
V
-
N
I
Y
P
Q
S
I
E
L
Q
E
W
A
K
A
G
V
F
----
E
D
L
S
--------
N
K
D
---
Y
------
L
K
R
V
K
N
G
Y
A
E
K
Y
A
V
-----
N
E
K
V
Y
N
V
P
F
T
-
A
N
A
Y
-
G
I
Y
Y
N
K
D
K
F
E
E
L
G
L
---
K
-
V
P
E
T
W
D
E
F
E
Q
L
V
K
D
I
V
A
K
G
---
Q
T
P
F
G
I
A
G
A
D
A
W
T
L
N
G
Y
N
Q
L
A
F
A
T
A
T
G
G
G
K
E
A
N
Q
Y
--
L
R
Y
S
Q
P
N
-
A
I
K
L
-
S
D
P
I
M
K
D
D
I
K
V
M
D
I
L
R
I
N
G
S
K
Q
K
N
W
E
G
A
G
--
Y
T
D
-
V
I
G
A
F
A
R
G
D
V
L
M
T
P
N
-
G
S
W
A
I
T
A
I
N
E
Q
---
K
---
P
---
N
F
K
I
G
T
F
M
I
P
G
K
E
K
G
Q
---
S
--
L
-
T
V
-
G
A
G
-
D
L
A
W
S
I
S
A
T
T
K
H
P
K
E
A
N
A
F
V
E
-
Y
-
M
T
R
P
E
V
M
Q
K
Y
Y
D
V
D
G
S
P
-
T
A
I
E
G
V
K
Q
-
A
-
G
---
E
---
D
S
P
L
A
G
M
T
-
E
Y
A
F
T
D
-
R
H
-
L
-
V
W
L
----
Q
Q
Y
W
T
S
-
E
A
D
F
H
T
L
T
M
N
Y
V
L
T
G
---
D
K
Q
G
M
V
N
D
L
N
A
F
F
N
P
M
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
95.50
96%
-72
- C1 -
-
2HFB
-
?
A:
[23-405]
--------------------------------
T
V
T
I
E
Y
F
N
-
Q
K
K
--
E
M
T
K
T
L
E
E
I
T
R
D
F
E
K
----
E
N
P
K
I
K
V
K
V
V
N
V
-
P
N
--
A
G
-----
E
V
L
K
T
R
V
L
A
G
D
V
P
D
V
V
-
N
I
Y
P
Q
S
I
E
L
Q
E
W
A
K
A
G
V
F
----
E
D
L
S
--------
N
K
D
---
Y
------
L
K
R
V
K
N
G
Y
A
E
K
Y
A
V
-----
N
E
K
V
Y
N
V
P
F
T
-
A
N
A
Y
-
G
I
Y
Y
N
K
D
K
F
E
E
L
G
L
---
K
-
V
P
E
T
W
D
E
F
E
Q
L
V
K
D
I
V
A
K
G
---
Q
T
P
F
G
I
A
G
A
D
A
W
T
L
N
G
Y
N
Q
L
A
F
A
T
A
T
G
G
G
K
E
A
N
Q
Y
--
L
R
Y
S
Q
P
N
-
A
I
K
L
-
S
D
P
I
M
K
D
D
I
K
V
M
D
I
L
R
I
N
G
S
K
Q
K
N
W
E
G
A
G
--
Y
T
D
-
V
I
G
A
F
A
R
G
D
V
L
M
T
P
N
-
G
S
W
A
I
T
A
I
N
E
Q
---
K
---
P
---
N
F
K
I
G
T
F
M
I
P
G
K
E
K
G
Q
---
S
--
L
-
T
V
-
G
A
G
-
D
L
A
W
S
I
S
A
T
T
K
H
P
K
E
A
N
A
F
V
E
-
Y
-
M
T
R
P
E
V
M
Q
K
Y
Y
D
V
D
G
S
P
-
T
A
I
E
G
V
K
Q
-
A
-
G
---
E
---
D
S
P
L
A
G
M
T
-
E
Y
A
F
T
D
-
R
H
-
L
-
V
W
L
----
Q
Q
Y
W
T
S
-
E
-
A
D
F
H
T
L
T
M
N
Y
V
L
T
G
--
D
K
Q
G
M
V
N
D
L
N
A
F
F
N
P
M
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
28
HHSearch
94.99
96%
-68
- C1 -
-
2HEU
-
?
A:
[16-399]
------------------------------
S
S
T
V
T
I
E
Y
F
N
-
Q
K
K
--
E
M
T
K
T
L
E
E
I
T
R
D
F
E
K
----
E
N
P
K
I
-
V
K
V
V
N
V
-
P
N
--
A
G
-----
E
V
L
K
T
R
V
L
A
G
D
V
P
D
V
V
-
N
I
Y
P
Q
S
I
E
L
Q
E
W
A
K
A
G
V
F
----
E
D
L
S
--------
N
K
D
---
Y
------
L
K
R
V
K
N
G
Y
A
E
K
Y
A
V
-----
N
E
K
V
Y
N
V
P
F
T
-
A
N
A
Y
-
G
I
Y
Y
N
K
D
K
F
E
E
L
G
L
---
K
-
V
P
E
T
W
D
E
F
E
Q
L
V
K
D
I
V
A
K
G
---
Q
T
P
F
G
I
A
G
A
D
A
W
T
L
N
G
Y
N
Q
L
A
F
A
T
A
T
G
G
G
K
E
A
N
Q
Y
--
L
R
Y
S
Q
P
N
-
A
I
K
L
-
S
D
P
I
M
K
D
D
I
K
V
M
D
I
L
R
I
N
G
S
K
Q
K
N
W
E
G
A
G
--
Y
T
D
-
V
I
G
A
F
A
R
G
D
V
L
M
T
P
N
-
G
S
W
A
I
T
A
I
N
E
Q
---
K
---
P
---
N
F
K
I
G
T
F
M
I
P
G
K
E
K
G
Q
---
S
--
L
-
T
V
-
G
A
G
-
D
L
A
W
S
I
S
A
T
T
K
H
P
K
E
A
N
A
F
V
E
-
Y
-
M
T
R
P
E
V
M
Q
K
Y
Y
D
V
D
G
S
P
-
T
A
I
E
G
V
K
Q
-
A
-
G
---
E
---
D
S
P
L
A
G
M
T
-
E
Y
A
F
T
D
-
R
H
-
L
-
V
W
L
----
Q
Q
Y
W
T
S
-
E
A
D
F
H
T
L
T
M
N
Y
V
L
T
G
---
D
K
Q
G
M
V
N
D
L
N
A
F
F
N
P
M
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
51
Fugue
45.92
22%
5
- C1 -
-
5T0A
21
H6ST3_DANRE (first)
A:
[3-680]
----------------------------
I
E
E
G
K
L
V
I
W
I
N
G
-
D
K
G
----
Y
N
G
L
A
E
V
G
K
K
F
E
K
----
D
T
-
G
I
K
V
T
V
E
H
P
-
D
K
--
L
E
-----
E
K
F
P
Q
V
A
A
T
G
D
G
P
D
I
---
I
F
W
A
H
D
R
F
G
G
Y
A
Q
S
G
L
L
----
A
E
I
T
P
-------
A
A
A
---
F
------
Q
D
K
L
Y
P
F
T
W
D
A
V
R
Y
-----
N
G
K
L
I
A
Y
P
I
A
-
V
E
A
L
-
S
L
I
Y
N
K
D
L
L
P
N
P
--------
P
K
T
W
E
E
I
P
A
L
D
K
E
L
K
A
K
G
---
K
S
A
L
------
M
F
N
L
Q
E
P
Y
F
T
W
P
L
I
A
A
D
G
G
Y
A
F
K
Y
A
--
A
G
K
Y
D
I
K
-
D
V
G
V
-
D
N
A
G
A
K
A
G
L
T
F
L
V
D
L
I
K
N
K
H
M
N
A
D
---
T
D
--
Y
S
I
-
A
E
A
A
F
N
K
G
E
T
A
M
T
I
N
-
G
P
W
A
W
S
N
I
D
T
S
---
A
---
V
---
N
Y
G
V
T
V
L
P
T
F
---
K
G
Q
---
P
--
S
-
K
P
-
F
V
G
-
V
L
S
A
G
I
N
A
A
S
P
N
K
E
L
A
K
E
F
L
E
N
Y
-
L
L
T
-----------------
D
E
G
L
E
A
-
V
-
N
---
K
---
D
K
P
L
G
A
V
A
-
L
K
S
Y
E
E
-
E
L
---------------
A
-
K
-
D
P
R
I
A
A
T
M
E
N
A
Q
K
G
--
E
I
M
P
N
I
P
Q
M
S
A
F
W
Y
A
V
R
T
A
V
I
N
A
A
S
GRQT
V
D
A
A
L
A
A
A
Q
T
N
A
A
A
K
F
N
F
T
ERDL
T
R
D
V
DFNIKGD
D
V
I
V
F
LHIQKTG
G
T
T
F
G
R
H
L
V
RNIRLEQPCDCKAGQKKCTCHRPGKQESWLFSRFSTGWSCGLHAD
W
T
E
L
T
N
C
VPVIMDR
N
F
Y
Y
I
T
M
L
R
D
P
V
S
R
Y
L
S
E
W
K
H
V
Q
R
GATWKTSLHMCDGRSPTQDELPTCYNGDDWSGVT
L
H
D
F
M
D
CPSNLANN
R
Q
V
R
M
L
ADLSLVGCYNLSTMN
E
S
E
R
N
P
I
L
L
A
S
A
K
S
N
L
K
N
MA
F
Y
G
L
TEF
Q
R
K
T
Q
Y
L
F
E
R
T
F
HLRFI
S
A
F
T
Q
I
NSTRAANVELR
D
D
M
R
S
R
I
E
Q
L
N
M
L
D
M
Q
L
Y
E
F
A
K
D
L
F
L
Q
R
Y
Q
F
V
R
Q
R
E
R
Q
E
E
R
L
K
R
R
E
E
25
HHSearch
42.40
20%
34
* C1 *
-
3VXC
1
?
A:
[38-435]
----------------------------------
T
I
T
A
M
V
-
Y
G
D
--
D
A
V
K
V
Q
D
K
A
A
S
R
F
N
A
S
A
E
A
K
K
A
N
A
K
V
K
M
E
R
I
-
P
A
SD
Y
P
-----
A
K
L
R
T
A
M
G
S
P
N
A
P
D
I
F
-
F
N
W
G
G
G
-
S
I
K
A
Y
K
E
A
G
Q
L
----
V
D
L
T
--------
D
V
I
---
K
S
D
E
V
L
-
S
T
G
F
L
P
S
V
V
A
A
G
S
L
-----
D
G
H
E
Y
G
I
P
M
R
G
M
Q
P
V
-
L
L
F
Y
N
K
S
V
F
A
E
H
K
L
---
T
-
P
P
T
T
W
D
Q
L
L
D
N
V
A
K
L
K
K
A
G
---
V
T
P
F
A
L
G
G
V
E
I
W
P
E
L
M
W
L
E
Y
L
V
-
D
R
I
G
G
P
Q
----
V
--
F
D
K
I
R
N
G
D
A
S
G
W
-
G
D
P
A
V
L
K
A
A
Q
T
V
K
Q
L
V
D
E
G
A
F
G
K
G
F
S
S
V
S
YN
N
G
G
-
A
P
A
L
L
A
K
G
K
A
G
M
H
L
M
-
G
S
W
E
Y
S
T
Q
L
G
K
---
F
---
P
D
F
A
K
K
D
L
G
W
C
A
F
P
S
F
E
G
G
A
---
G
DI
R
-
N
V
V
G
N
P
-
C
N
Y
W
S
V
N
A
R
T
G
N
K
D
G
A
I
A
F
L
R
-
D
-
C
A
S
E
A
Y
T
K
D
L
I
D
-
N
G
D
V
-
P
T
T
T
I
A
E
N
-
M
-
L
DSS
P
---
N
P
E
F
A
K
F
Q
-
Y
Q
L
V
Q
K
A
P
N
F
T
L
S
W
D
----
Q
A
V
D
P
D
-
W
Q
Q
P
M
L
T
E
I
N
K
L
F
V
G
K
S-
S
P
E
Q
F
V
S
A
L
K
G
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
46
Fugue
41.88
17%
35
- C1 -
-
2B3F
1
?
A:
[1-392]
---------------------------------
M
K
L
E
I
F
S
W
W
A
G
--
D
E
G
P
A
L
E
A
L
I
R
L
Y
K
Q
----
K
Y
P
G
V
E
V
I
N
A
T
V
-
T
G
--
G
A
G
V
N
A
R
A
V
L
K
T
R
M
L
G
G
D
P
P
D
T
F
-
Q
V
H
A
G
M
E
L
I
G
T
W
V
V
A
N
R
M
EDL
S
A
L
F
R
--------
Q
E
G
---
W
------
L
Q
A
F
P
K
G
L
I
D
L
I
S
Y
-----
K
G
G
I
W
S
V
P
V
N
-
I
H
R
S
N
V
M
W
Y
L
P
A
K
L
K
G
W
G
V
---
N
-
P
P
R
T
W
D
K
F
L
A
T
C
Q
T
L
K
Q
K
G
---
L
E
A
P
-
L
A
L
G
E
N
W
T
Q
Q
H
L
W
E
S
V
A
L
A
V
L
G
-----
P
D
D
--
W
N
N
L
W
N
G
-
K
L
K
F
-
T
D
P
K
A
V
R
A
W
E
V
F
G
R
V
L
D
C
A
N
K
--
D
A
A
G
L
S
--
W
Q
Q
-
A
V
D
R
V
V
Q
G
K
A
A
F
N
I
M
-
G
D
W
A
A
G
Y
M
T
T
T
LKL
K
---
P
---
G
T
D
F
A
W
A
P
S
P
G
T
Q
G
----------
V
F
-
M
M
L
-
S
D
S
F
G
L
P
K
G
A
K
N
R
Q
N
A
I
N
W
L
R
-
L
-
V
G
S
K
E
G
Q
D
T
S
N
P
L
K
G
S
I
-
A
A
R
L
D
S
D
P
-
S
-
K
---
Y
---
N
A
Y
G
Q
S
A
M
-
R
D
W
R
S
N
-
R
I
-
V
-
G
S
L
VHGA
V
A
P
E
S
F
-
M
-
S
Q
F
G
T
V
M
E
I
F
L
Q
T
R
--
N
P
Q
A
A
A
N
A
A
Q
A
I
A
D
Q
V
G
L
G
R
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
37
HHSearch
41.44
19%
43
- C1 -
-
4G68
-
?
C:
[39-430]
---------------------------------
I
T
L
T
F
W
N
-
L
F
T
GE
P
A
K
T
K
V
K
E
I
I
D
Q
W
N
K
----
E
N
P
N
V
Q
I
V
E
S
V
T
-
E
N
DA
Y
K
-----
T
K
I
K
A
A
I
A
A
N
E
A
P
D
I
F
-
Q
T
W
A
G
G
-
F
S
Q
P
F
V
E
A
G
K
V
----
L
Q
L
D
--------
S
Y
L
NDG
T
------
K
D
Q
L
L
P
G
S
F
D
N
V
T
Y
-----
N
G
K
I
Y
G
I
P
F
D
-
Q
Q
A
S
-
V
L
Y
I
N
K
E
L
F
D
K
Y
N
V
---
K
-
V
P
T
T
F
S
E
L
I
D
A
I
K
T
F
K
S
K
G
---
V
T
P
F
A
L
G
E
K
D
E
W
P
G
M
W
Y
Y
D
M
I
A
L
R
-
E
G
G
V
Q
L
T
R
------
D
A
L
N
G
-
K
A
S
F
-
D
N
Q
A
F
T
D
A
A
Q
K
L
Q
D
M
V
N
A
G
A
F
D
S
G
F
M
G
L
T
--
R
D
E
-
A
T
A
E
F
N
Q
G
K
A
A
M
Y
F
G
-
G
N
F
D
A
A
A
F
V
S
D
---
P
SSL
V
---
K
G
K
I
E
A
V
R
F
P
T
I
E
G
G
K
GD-
P
--
T
E
Y
I
-
G
G
T
-
V
G
A
L
M
V
S
A
N
S
K
Y
K
D
E
A
V
R
A
A
K
-
Y
-
L
A
K
Q
L
S
D
M
D
Y
L
I
A
T
G
-
L
-
P
A
W
K
Y
D
N
I
D
Q
-
S
K--
V
---
D
P
L
E
I
Q
I
M
N
N
I
V
A
N
A
K
G
S
-
V
-
P
A
W
----
D
I
Y
L
S
G
D
A
A
Q
T
H
K
D
L
V
A
Q
L
F
A
K
Q
I-
T
P
E
E
Y
S
K
Q
M
Q
Q
K
I
N
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
HHSearch
40.93
20%
38
- C1 -
-
3VXB
4
?
A:
[38-435]
----------------------------------
T
I
T
A
M
V
-
Y
G
D
--
D
A
V
K
V
Q
D
K
A
A
S
R
F
N
A
S
A
E
A
K
K
A
N
A
K
V
K
M
E
R
I
-
P
A
SD
Y
P
-----
A
K
L
R
T
A
M
G
S
P
N
A
P
D
I
F
-
F
N
W
G
G
G
-
S
I
K
A
Y
K
E
A
G
Q
L
----
V
D
L
T
--------
D
V
I
---
K
S
D
E
V
L
-
S
T
G
F
L
P
S
V
V
A
A
G
S
L
-----
D
G
H
E
Y
G
I
P
M
R
G
M
Q
P
V
-
L
L
F
Y
N
K
S
V
F
A
E
H
K
L
---
T
-
P
P
T
T
W
D
Q
L
L
D
N
V
A
K
L
K
K
A
G
---
V
T
P
F
A
L
G
G
V
E
I
W
P
E
L
M
W
L
E
Y
L
V
-
D
R
I
G
G
P
Q
----
V
--
F
D
K
I
R
N
G
D
A
S
G
W
-
G
D
P
A
V
L
K
A
A
Q
T
V
K
Q
L
V
D
E
G
A
F
G
K
G
F
S
S
V
S
YN
N
G
G
-
A
P
A
L
L
A
K
G
K
A
G
M
H
L
M
-
G
S
W
E
Y
S
T
Q
L
G
K
---
F
---
P
D
F
A
K
K
D
L
G
W
C
A
F
P
S
F
E
G
G
A
---
G
DI
R
-
N
V
V
G
N
P
-
C
N
Y
W
S
V
N
A
R
T
G
N
K
D
G
A
I
A
F
L
R
-
D
-
C
A
S
E
A
Y
T
K
D
L
I
D
-
N
G
D
V
-
P
T
T
T
I
A
E
N
-
M
-
L
DSS
P
---
N
P
E
F
A
K
F
Q
-
Y
Q
L
V
Q
K
A
P
N
F
T
L
S
W
D
----
Q
A
V
D
P
D
-
W
Q
Q
P
M
L
T
E
I
N
K
L
F
V
G
K
S-
S
P
E
Q
F
V
S
A
L
K
G
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
26
HHSearch
40.07
19%
44
- C1 -
-
4G68
1
?
A:
[63-454]
---------------------------------
I
T
L
T
F
W
N
-
L
F
T
GE
P
A
K
T
K
V
K
E
I
I
D
Q
W
N
K
----
E
N
P
N
V
Q
I
V
E
S
V
T
-
E
N
D
A
Y
K
-----
T
K
I
K
A
A
I
A
A
N
E
A
P
D
I
F
-
Q
T
W
A
G
G
-
F
S
Q
P
F
V
E
A
G
K
V
----
L
Q
L
D
--------
S
Y
L
NDG
T
------
K
D
Q
L
L
P
G
S
F
D
N
V
T
Y
-----
N
G
K
I
Y
G
I
P
F
D
-
Q
Q
A
S
-
V
L
Y
I
N
K
E
L
F
D
K
Y
N
V
---
K
-
V
P
T
T
F
S
E
L
I
D
A
I
K
T
F
K
S
K
G
---
V
T
P
F
A
L
G
E
K
D
E
W
P
G
M
W
Y
Y
D
M
I
A
L
R
-
E
G
G
V
Q
L
T
R
-----
D
-
A
L
N
G
-
K
A
S
F
-
D
N
Q
A
F
T
D
A
A
Q
K
L
Q
D
M
V
N
A
G
A
F
D
S
G
F
M
G
L
T
--
R
D
E
-
A
T
A
E
F
N
Q
G
K
A
A
M
Y
F
G
-
G
N
F
D
A
A
A
F
V
S
D
---
P
SSL
V
---
K
G
K
I
E
A
V
R
F
P
T
I
E
G
G
K
GD-
P
--
T
E
Y
I
-
G
G
T
-
V
G
A
L
M
V
S
A
N
S
K
Y
K
D
E
A
V
R
A
A
K
-
Y
-
L
A
K
Q
L
S
D
M
D
Y
L
I
A
T
G
-
L
-
P
A
W
K
Y
D
N
I
-
D
Q
S
K--
V
---
D
P
L
E
I
Q
I
M
N
N
I
V
A
N
A
K
G
S
-
V
-
P
A
W
----
D
I
Y
L
S
G
D
A
A
Q
T
H
K
D
L
V
A
Q
L
F
A
K
Q
I-
T
P
E
E
Y
S
K
Q
M
Q
Q
K
I
N
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
39.82
26%
19
- C1 -
-
4ZZE
3
?
A:
[8-327]
--------------------------------
Q
V
T
L
D
F
F
Q
-
F
K
A
--
E
A
A
D
W
F
K
Q
A
A
Q
E
F
E
K
----
E
N
P
D
I
R
I
N
I
N
---------------
D
L
R
T
R
F
V
K
D
R
V
P
D
V
I
-
T
-
F
N
G
D
Y
S
F
G
T
F
A
A
S
G
V
F
----
H
D
F
T
DD
P
L
V
S
E
L
N
E
G
---
M
------
V
N
I
A
K
N
L
V
Q
T
S
D
P
A
-----
K
K
R
L
Y
G
L
P
F
A
-
G
N
A
S
-
G
Y
I
Y
N
K
D
L
F
R
K
V
G
L
DPD
N
-
P
P
Q
T
W
D
E
F
I
A
M
L
K
K
F
R
D
A
G
---
I
N
P
V
Q
A
T
L
A
D
A
W
T
----
T
Q
A
P
L
A
S
L
A
G
T
L
V
P
E
S
E
Y
A
A
L
K
S
G
D
T
T
-
F
K
Q
I
W
T
E
P
I
E
K
E
----
I
E
L
F
K
Y
A
D
S
E
K
----
G
V
T
--
Y
Q
Q
-
G
T
Q
N
F
A
K
G
T
A
A
I
I
P
L
-
G
T
Y
A
I
P
Q
I
T
M
V
---
N
---
K
---
D
I
D
L
G
F
A
Q
M
P
A
T
N
D
A
S
---
K
--
Q
-
I
L
-
T
A
G
D
D
V
I
L
T
M
G
A
N
S
R
H
K
E
Q
S
M
R
F
I
R
-
F
-
L
M
S
K
K
Q
L
E
N
Y
A
D
A
Q
S
A
I
-
T
P
L
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
39.80
26%
17
- C1 -
-
4ZS9
1
?
A:
[25-344]
--------------------------------
Q
V
T
L
D
F
F
Q
-
F
K
A
--
E
A
A
D
W
F
K
Q
A
A
Q
E
F
E
K
----
E
N
P
D
I
R
I
N
I
N
N
---------------
L
R
T
R
F
V
K
D
R
V
P
D
V
I
-
T
-
F
N
G
D
Y
S
F
G
T
F
A
A
S
G
V
F
----
H
D
F
T
DD
P
L
V
S
E
L
N
E
G
---
M
------
V
N
I
A
K
N
L
V
Q
T
S
D
P
A
-----
K
K
R
L
Y
G
L
P
F
A
-
G
N
A
S
-
G
Y
I
Y
N
K
D
L
F
R
K
V
G
L
DPD
N
-
P
P
Q
T
W
D
E
F
I
A
M
L
K
K
F
R
D
A
G
---
I
N
P
V
Q
A
T
L
A
D
A
W
T
----
T
Q
A
P
L
A
S
L
A
G
T
L
V
P
E
S
E
Y
A
A
L
K
S
G
D
T
T
-
F
K
Q
I
W
T
E
P
I
E
K
E
----
I
E
L
F
K
Y
A
D
S
E
K
----
G
V
T
--
Y
Q
Q
-
G
T
Q
N
F
A
K
G
T
A
A
I
I
P
L
-
G
T
Y
A
I
P
Q
I
T
M
V
---
N
---
K
---
D
I
D
L
G
F
A
Q
M
P
A
T
N
D
A
S
---
K
--
Q
-
I
L
-
T
A
G
D
D
V
I
L
T
M
G
A
N
S
R
H
K
E
Q
S
M
R
F
I
R
-
F
-
L
M
S
K
K
Q
L
E
N
Y
A
D
A
Q
S
A
I
-
T
P
L
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
35
HHSearch
39.21
21%
-
- C1 -
-
3UOR
-
?
A:
[27-413]
--------------------------------
K
T
T
V
R
F
W
A
-
M
G
K
---
E
A
E
V
V
A
E
L
V
A
D
F
E
K
----
Q
N
P
T
I
H
V
D
V
Q
N
I
-
P
M
TA
A
H
-----
E
K
L
L
T
A
F
A
A
D
G
L
P
D
V
C
-
Q
L
G
N
-
T
-
W
L
P
E
F
A
L
L
D
T
L
----
E
P
M
Q
--------
P
Y
V
---
A
R
SKIVD
P
A
D
Y
F
P
G
V
W
D
T
N
L
V
-----
D
G
T
L
Y
G
V
P
W
Y
-
V
D
T
R
-
L
L
F
Y
R
K
D
L
L
R
E
A
G
Y
---
S
Q
M
P
K
T
W
A
E
M
E
Q
V
M
A
A
I
K
R
K
V
GPD
R
Y
A
I
L
M
P
L
N
-
E
F
E
--
Q
Q
L
S
-
F
A
-
L
Q
Q
D
D
R
L
-------
L
R
-
D
H
D
N
-
Y
G
N
F
-
R
G
A
G
F
R
K
A
L
G
F
Y
D
N
M
Y
Q
Q
G
W
A
P
K
V
S
E
-
T
Q
--
V
S
N
-
V
W
Y
E
F
F
N
G
Y
Y
A
F
Y
L
S
-
G
P
W
N
V
R
E
F
K
L
R
---
Q
PPG
M
---
E
G
N
W
G
T
A
P
L
P
G
P
N
G
L
----
G
--
A
-
G
I
-
A
G
--
G
S
S
L
V
I
F
K
S
S
Q
H
K
D
A
S
W
K
L
I
E
-
Y
-
L
S
Q
P
Q
V
Q
A
R
F
H
A
I
I
G
D
L
-
P
P
R
R
S
T
W
K
-
L
-
P
---
S
LAN
D
A
L
A
H
A
F
G
-
D
Q
L
E
R
V
-
K
A
-
T
-
P
K
-----
V
L
E
W
E
R
-
I
V
Q
E
M
R
L
V
T
E
R
V
V
R
G
G
Q-
S
H
D
A
A
V
Q
E
L
D
Q
R
V
D
E
I
L
A
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
36
HHSearch
39.07
21%
-
- C1 -
-
3UOR
-
?
B:
[28-413]
---------------------------------
T
T
V
R
F
W
A
-
M
G
K
---
E
A
E
V
V
A
E
L
V
A
D
F
E
K
----
Q
N
P
T
I
H
V
D
V
Q
N
I
-
P
M
TA
A
H
-----
E
K
L
L
T
A
F
A
A
D
G
L
P
D
V
C
-
Q
L
G
N
-
T
-
W
L
P
E
F
A
L
L
D
T
L
----
E
P
M
Q
--------
P
Y
V
---
A
R
SKIVD
P
A
D
Y
F
P
G
V
W
D
T
N
L
V
-----
D
G
T
L
Y
G
V
P
W
Y
-
V
D
T
R
-
L
L
F
Y
R
K
D
L
L
R
E
A
G
Y
---
S
Q
M
P
K
T
W
A
E
M
E
Q
V
M
A
A
I
K
R
K
V
GPD
R
Y
A
I
L
M
P
L
N
-
E
F
E
--
Q
Q
L
S
-
F
A
-
L
Q
Q
D
D
R
L
-------
L
R
-
D
H
D
N
-
Y
G
N
F
-
R
G
A
G
F
R
K
A
L
G
F
Y
D
N
M
Y
Q
Q
G
W
A
P
K
V
S
E
-
T
Q
--
V
S
N
-
V
W
Y
E
F
F
N
G
Y
Y
A
F
Y
L
S
-
G
P
W
N
V
R
E
F
K
L
R
---
Q
PPG
M
---
E
G
N
W
G
T
A
P
L
P
G
P
N
G
L
----
G
--
A
-
G
I
-
A
G
--
G
S
S
L
V
I
F
K
S
S
Q
H
K
D
A
S
W
K
L
I
E
-
Y
-
L
S
Q
P
Q
V
Q
A
R
F
H
A
I
I
G
D
L
-
P
P
R
R
S
T
W
K
-
L
-
P
---
S
LAN
D
A
L
A
H
A
F
G
-
D
Q
L
E
R
V
-
K
A
-
T
-
P
K
-----
V
L
E
W
E
R
-
I
V
Q
E
M
R
L
V
T
E
R
V
V
R
G
G
Q-
S
H
D
A
A
V
Q
E
L
D
Q
R
V
D
E
I
L
A
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
50
Fugue
38.24
14%
21
- C1 -
-
3I3V
-
?
A:
[39-429]
-----------------------------
P
D
T
L
V
V
H
T
Q
L
G
-
T
T
A
--
P
G
S
P
T
Y
L
A
A
V
D
R
F
R
E
----
E
N
P
G
V
K
I
K
N
L
V
N
G
D
D
--
L
A
-----
Q
V
Y
E
T
S
R
L
A
R
K
E
A
D
V
V
M
V
N
L
Y
D
K
--
T
L
A
W
T
D
V
G
A
T
----
V
D
V
K
--------
P
Y
L
---
D
------
D
W
G
L
R
G
R
V
L
P
A
A
L
A
D
W
TDD
E
G
R
V
R
A
F
P
Y
F
-
A
T
N
W
-
P
V
A
Y
N
R
A
L
L
D
R
A
G
V
D--
A
-
I
P
T
T
G
D
Q
L
I
A
A
A
R
K
L
R
A
K
G
---
I
A
P
V
T
V
G
G
N
D
W
T
G
Q
K
L
L
A
Q
I
I
Q
T
F
---
L
S
Q
D
E
A
R
H
--
V
Y
S
T
-----
G
D
F
-
G
V
R
G
A
R
L
G
I
E
Y
F
A
H
L
R
D
A
G
V
F
A
D
K
A
Q
G
L
T
--
S
D
S
M
T
-
T
Q
F
N
T
E
E
A
A
V
Q
S
A
M
S
S
A
L
A
K
V
P
E
K
V
---
A
---
G
---
H
T
E
V
G
G
W
P
L
A
D
G
A
A
H
D
G
P
T
V
--
I
-
R
A
-
Y
T
L
-
I
G
F
W
I
S
P
N
G
V
R
K
I
E
Q
V
E
K
F
L
R
-
F
M
Y
R
-
P
D
V
V
A
R
F
V
T
E
S
G
R
D
M
A
L
R
T
D
A
V
S
-
T
-
G
---
F
---
P
L
V
G
A
A
Q
R
-
L
G
S
E
V
S
-
Q
V
-
L
-
L
P
D
----
V
Y
V
P
P
A
-
A
-
A
Q
P
L
I
T
A
T
S
T
S
F
T
R
GT
S
P
A
R
V
R
A
A
L
E
S
A
Y
R
S
V
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
38.13
26%
18
- C1 -
-
4ZZA
1
?
A:
[9-327]
---------------------------------
V
T
L
D
F
F
Q
-
F
K
A
--
E
A
A
D
W
F
K
Q
A
A
Q
E
F
E
K
----
E
N
P
D
I
R
I
N
I
N
------------------------
R
V
P
D
V
I
--
T
F
N
G
D
Y
S
F
G
T
F
A
A
S
G
V
F
----
H
D
F
T
DD
P
L
V
S
E
L
N
E
G
---
M
------
V
N
I
A
K
N
L
V
Q
T
S
D
P
A
-----
K
K
R
L
Y
G
L
P
F
A
-
G
N
A
S
-
G
Y
I
Y
N
K
D
L
F
R
K
V
G
L
DPD
N
-
P
P
Q
T
W
D
E
F
I
A
M
L
K
K
F
R
D
A
G
---
I
N
P
V
Q
A
T
L
A
D
A
W
T
----
T
Q
A
P
L
A
S
L
A
G
T
L
V
P
E
S
E
Y
A
A
L
K
S
G
D
T
T
-
F
K
Q
I
W
T
E
P
I
E
K
E
----
I
E
L
F
K
Y
A
D
S
E
K
----
G
V
T
--
Y
Q
Q
-
G
T
Q
N
F
A
K
G
T
A
A
I
I
P
L
-
G
T
Y
A
I
P
Q
I
T
M
V
---
N
---
K
---
D
I
D
L
G
F
A
Q
M
P
A
T
N
D
A
S
---
K
--
Q
-
I
L
-
T
A
G
D
D
V
I
L
T
M
G
A
N
S
R
H
K
E
Q
S
M
R
F
I
R
-
F
-
L
M
S
K
K
Q
L
E
N
Y
A
D
A
Q
S
A
I
-
T
P
L
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------