@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : spr1801: (2018-01-20 )
MIDIQGLEKKFNDRAIFSGLNLKLEKGKVYALIGKSGSGKTTLLNILGKLEKIDGGRVLYQGKDLKTIPTREYFRDQMGYLFQNFGLLENQSIKENLDLGFVGQKISKVERLERQVGALEKVNLGYLDLEQKIYTLSGGEAQRVALAKTILKNPPLILADEPTAALDPENSEEVMNLLVDLKDENRIIIIATHNPLVWNKADEIIDMRKLAHV
Atome Classification :
(32 SA)
.........--10..-.....--.20........30........40........50........60--........-.70--.-..----....-..80........90........100----...-.---.....110.....---.---.120....-..---.-130.......140.......150.......160.......170.......180.-.-.-....190.......-200.......210.
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MI
D
I
Q
G
L
E
K
--KFND-
R
A
IFS--GL
N
L
K
L
EK
G
K
V
Y
A
L
I
GKSGSG
K
T
T
L
L
N
I
L
G
K
L
E
KIDG
G
R
V
L
Y---QGKDLKTI-
P
T
---
R
-
E
Y
----
F
R
D
Q
-
M
G
Y
L
F
Q
N
FGLLENQ
S
I
K
ENLDL
G
------
F
V
G
-
Q
---
K
I
S
K
V
E
R
L
E
R
Q
VG---A---LEKVNL
G
Y
-
L
D
---L-
E
Q
K
I
Y
TLSGGE
A
Q
R
V
A
L
A
K
T
I
LKNP
P
L
I
L
ADEPTAALDPE
N
S
E
E
V
M
N
L
L
V
DLKD-E-N-
R
I
I
I
I
ATHNPLVWN-
K
A
D
E
I
I
D
M
R
K
L
AHV
2
PsiBlast_PDB
87.03
36%
0
- C- -
-
5NIL
-
?
J:
[23-236]
------------------
V
L
K
--
G
I
S
L
D
I
Y
A
G
E
M
V
A
I
V
G
A
S
G
S
G
K
S
T
L
M
N
I
L
G
C
L
D
K
A
T
S
G
T
Y
R
V
---
A
G
Q
D
V
A
T
L
-
D
A
DAL
A
-
Q
L
----
R
R
E
H
-
F
G
F
I
F
Q
R
Y
H
L
L
S
H
L
T
A
E
Q
N
V
E
V
P
------
A
V
Y
-
A
---
G
L
E
R
K
Q
R
L
L
R
A
Q
E
---
L
---
L
Q
R
--
L
G
L
-
E
D
R--
T
-
E
Y
Y
P
A
Q
L
S
G
G
Q
Q
Q
R
V
S
I
A
R
A
L
M
N
G
G
Q
V
I
L
A
D
E
P
T
G
A
L
D
S
H
S
G
E
E
V
M
A
I
L
H
Q
L
R
D
-
R
-
G
-
H
T
V
I
I
V
T
H
D
P
Q
V
A
A
-
Q
A
E
R
V
I
E
I
R
-----
1
PsiBlast_PDB
87.03
36%
0
- C- -
-
5NIK
-
?
J:
[23-236]
------------------
V
L
K
--
G
I
S
L
D
I
Y
A
G
E
M
V
A
I
V
G
A
S
G
S
G
K
S
T
L
M
N
I
L
G
C
L
D
K
A
T
S
G
T
Y
R
V
---
A
G
Q
D
V
A
T
L
-
D
A
DAL
A
-
Q
L
----
R
R
E
H
-
F
G
F
I
F
Q
R
Y
H
L
L
S
H
L
T
A
E
Q
N
V
E
V
P
------
A
V
Y
-
A
---
G
L
E
R
K
Q
R
L
L
R
A
Q
E
---
L
---
L
Q
R
--
L
G
L
-
E
D
R--
T
-
E
Y
Y
P
A
Q
L
S
G
G
Q
Q
Q
R
V
S
I
A
R
A
L
M
N
G
G
Q
V
I
L
A
D
E
P
T
G
A
L
D
S
H
S
G
E
E
V
M
A
I
L
H
Q
L
R
D
-
R
-
G
-
H
T
V
I
I
V
T
H
D
P
Q
V
A
A
-
Q
A
E
R
V
I
E
I
R
-----
153
HHSearch
80.54
29%
-97
- C1 -
-
2YYZ
1
?
A:
[3-212]
S
I
R
V
V
N
L
K
K
--
Y
F
G
K
-
V
K
A
V
D
--
G
V
S
F
E
V
K
D
G
E
F
V
A
L
L
G
P
S
G
C
G
K
T
T
T
L
L
M
L
A
G
I
Y
K
P
T
S
G
E
I
Y
F
---
D
D
V
L
V
N
D
I
-
P
P
-----------
K
Y
R
E
-
V
G
M
V
F
Q
N
Y
A
L
Y
P
H
M
T
V
F
E
N
I
A
F
P
------
L
R
A
-
R
---
R
I
S
K
D
E
V
E
K
R
V
V
E
---
I
---
A
R
K
L
L
I
D
N
--
L
---
L
-
D
R
K
P
T
Q
L
S
G
G
Q
Q
Q
R
V
A
L
A
R
A
L
V
K
Q
P
K
V
L
L
F
D
E
P
L
S
N
L
D
A
N
L
R
M
I
M
R
A
E
I
K
H
L
Q
Q
-
E
L
G
-
I
T
S
V
Y
V
T
H
D
Q
A
E
A
M
T
M
A
S
R
I
A
V
F
N
Q
G
K
L
-
142
HHSearch
79.35
28%
-111
- C1 -
-
3RLF
2
MALK_ECOLI
A:
[3-211]
S
V
Q
L
Q
N
V
T
K
--
A
W
G
E
-
V
V
V
S
K
--
D
I
N
L
D
I
H
E
G
E
F
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
I
A
G
L
E
T
I
T
S
G
D
L
F
I
---
G
E
K
R
M
N
D
T
-
P
P
-----------
A
E
R
G
-
V
G
M
V
F
Q
S
Y
A
L
Y
P
H
L
S
V
A
E
N
M
S
F
G
------
L
K
L
-
A
---
G
A
K
K
E
V
I
N
Q
R
V
N
Q
---
V
---
A
E
V
L
Q
L
A
H
--
L
---
L
-
D
R
K
P
K
A
L
S
G
G
Q
R
Q
R
V
A
I
G
R
T
L
V
A
E
P
S
V
F
L
L
D
E
P
L
S
N
L
D
A
A
L
R
V
Q
M
R
I
E
I
S
R
L
H
K
R
L
-
G
-
R
T
M
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
K
I
V
V
L
D
A
G
R
--
106
PsiBlast_CBE
78.12
31%
-68
- C1 -
-
3NHA
3
A:
[54-259]
-
I
E
F
E
N
V
H
F
--
S
Y
A
D
-
R
E
T
L
Q
--
D
V
S
F
T
V
M
P
G
Q
T
L
A
L
V
G
P
S
G
A
G
K
S
T
I
L
R
L
L
F
R
F
Y
D
I
S
S
G
C
I
R
I
---
D
G
Q
D
I
S
Q
V
--
T
---
Q
-
A
S
----
L
R
S
H
-
I
G
V
V
P
Q
D
T
-
V
L
F
N
D
T
I
A
D
N
I
R
Y
G
------
R
V
T
-
A
---
G
N
D
E
V
E
A
A
A
Q
A
A
G
I
H
D
A
---
I
M
A
F
P
E
G
Y
R
T
Q
---
V
-
G
E
R
G
L
K
L
S
G
G
E
K
Q
R
V
A
I
A
R
T
I
L
K
A
P
G
I
I
L
L
D
E
A
T
S
A
L
D
T
S
N
E
R
A
I
Q
A
S
L
A
K
V
C
--
A
-
N
-
R
T
T
I
V
V
A
H
R
L
S
T
V
V
-
N
A
D
Q
I
L
--------
141
HHSearch
78.01
28%
-106
- C1 -
-
2AWN
1
MALK_ECOLI
B:
[3-211]
S
V
Q
L
Q
N
V
T
K
--
A
W
G
E
-
V
V
V
S
K
--
D
I
N
L
D
I
H
E
G
E
F
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
I
A
G
L
E
T
I
T
S
G
D
L
F
I
---
G
E
K
R
M
N
D
T
-
P
P
-----------
A
E
R
G
-
V
G
M
V
F
Q
S
Y
A
L
Y
P
H
L
S
V
A
E
N
M
S
F
G
------
L
K
L
-
A
---
G
A
K
K
E
V
I
N
Q
R
V
N
Q
---
V
---
A
E
V
L
Q
L
A
H
--
L
---
L
-
D
R
K
P
K
A
L
S
G
G
Q
R
Q
R
V
A
I
G
R
T
L
V
A
E
P
S
V
F
L
L
D
E
P
L
S
N
L
D
A
A
L
R
V
Q
M
R
I
E
I
S
R
L
H
K
R
L
-
G
-
R
T
M
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
K
I
V
V
L
D
A
G
R
--
105
PsiBlast_CBE
74.85
31%
-70
- C1 -
-
3NHB
2
A:
[54-259]
-
I
E
F
E
N
V
H
F
--
S
Y
A
D
-
R
E
T
L
Q
--
D
V
S
F
T
V
M
P
G
Q
T
L
A
L
V
G
P
S
G
A
G
K
S
T
I
L
R
L
L
F
R
F
Y
D
I
S
S
G
C
I
R
I
---
D
G
Q
D
I
S
Q
V
--
T
---
Q
-
A
S
----
L
R
S
H
-
I
G
V
V
P
Q
D
T
-
V
L
F
N
D
T
I
A
D
N
I
R
Y
G
------
R
V
T
-
A
---
G
N
D
E
V
E
A
A
A
Q
A
A
G
I
H
D
A
---
I
M
A
F
P
E
G
Y
R
T
Q
---
V
-
G
E
R
G
L
K
L
S
G
G
E
K
Q
R
V
A
I
A
R
T
I
L
K
A
P
G
I
I
L
L
D
E
A
T
S
A
L
D
T
S
N
E
R
A
I
Q
A
S
L
A
K
V
C
--
A
-
N
-
R
T
T
I
V
V
A
H
R
L
S
T
V
V
-
N
A
D
Q
I
L
--------
152
HHSearch
74.72
27%
-106
- C1 -
-
4TQU
-
?
T:
[4-213]
S
V
S
I
Q
N
V
V
K
--
R
Y
D
K
-
T
T
V
V
H
--
G
V
S
L
D
I
E
P
G
E
F
V
V
L
V
G
P
S
G
C
G
K
S
T
T
L
R
M
V
A
G
L
E
E
I
S
G
G
T
I
R
I
---
D
G
R
V
I
N
D
L
-
A
P
-----------
K
D
R
D
-
V
A
M
V
F
Q
N
Y
A
L
Y
P
H
L
N
V
R
D
N
I
S
F
G
------
L
R
L
-
K
---
R
T
K
K
S
V
I
D
A
A
V
K
T
---
A
---
A
D
I
L
G
L
Q
P
--
L
---
L
-
E
R
K
P
S
D
L
S
G
G
Q
R
Q
R
V
A
M
G
R
A
I
V
R
D
P
K
V
F
L
F
D
Q
P
L
S
N
L
D
A
K
L
R
T
Q
M
R
A
E
I
K
R
L
H
Q
R
L
-
G
-
T
T
V
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
R
I
V
V
M
R
D
G
L
I
-
20
PsiBlast_PDB
70.76
34%
-13
- C1 -
-
2PCJ
-
LOLD_AQUAE
A:
[19-213]
------------------
I
L
K
--
G
I
S
L
S
V
K
K
G
E
F
V
S
I
I
G
A
S
G
S
G
K
S
T
L
L
Y
I
L
G
L
L
D
A
P
T
E
G
K
V
F
L
---
E
G
K
E
V
D
Y
T
-
N
E
---
K
-
E
L
S
L
--
L
R
N
R
K
L
G
F
V
F
Q
F
H
Y
L
I
P
E
L
T
A
L
E
N
V
I
V
P
------
M
L
K
-
M
---
G
K
P
K
K
E
A
K
E
R
G
E
Y
---
L
---
L
S
E
L
G
L
G
D
--
K
---
L
-
S
R
K
P
Y
E
L
S
G
G
E
Q
Q
R
V
A
I
A
R
A
L
A
N
E
P
I
L
L
F
A
D
E
P
T
G
N
L
D
S
A
N
T
K
R
V
M
D
I
F
L
K
I
N
E
-
G
-
G
-
T
S
I
V
M
V
T
H
E
R
E
L
A
E
-
L
T
H
R
T
L
E
M
K
-----
33
PsiBlast_CBE
70.68
35%
3
- C1 -
-
3TIF
3
Y796_METJA
B:
[24-219]
------------------------
V
N
L
N
I
K
E
G
E
F
V
S
I
M
G
P
S
G
S
G
K
S
T
M
L
N
I
I
G
C
L
D
K
P
T
E
G
E
V
Y
I
DNI
K
T
N
D
L
D
D
D
-
E
L
---
T
-
K
I
----
R
R
D
K
-
I
G
F
V
F
Q
Q
F
N
L
I
P
L
L
T
A
L
E
N
V
E
L
P
------
L
I
F
-
K
---
Y
R
G
A
M
S
G
E
E
R
R
K
R
---
A
---
L
E
C
L
K
M
A
E
-
L
E
ERF
A
-
N
H
K
P
N
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
N
N
P
P
I
I
L
A
D
Q
P
T
W
A
L
D
S
K
T
G
E
K
I
M
Q
L
L
K
K
L
N
E
-
E
-
D
G
K
T
V
V
V
V
T
H
D
I
N
V
A
R
-
F
G
E
R
I
I
Y
L
K
-----
73
PsiBlast_CBE
70.25
33%
-47
- C1 -
-
1XEF
2
HLYBP_ECOLX
A:
[12-212]
-----------
K
P
D
S
-
P
V
I
L
D
--
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
N
G
Q
V
L
I
---
D
G
H
D
L
-
A
L
-
A
D
---
P
-
N
W
----
L
R
R
Q
-
V
G
V
V
L
Q
D
N
V
L
L
-
N
R
S
I
I
D
N
I
S
L
A
------
N
P
G
-
M
---
S
V
E
K
V
I
Y
A
A
K
L
A
G
---
A
H
D
F
I
S
E
L
R
E
G
Y
-
N
T
---
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
K
-
G
-
R
-
T
V
I
I
I
A
A
R
L
S
T
V
K
N
--
A
D
R
I
I
V
M
E
K
----
35
PsiBlast_CBE
70.25
37%
-33
- C1 -
-
4YMU
1
?
A:
[1-194]
M
I
F
V
N
D
V
Y
K
--
N
F
G
S
-
L
E
V
L
K
--
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
K
G
E
V
F
I
---
D
G
V
K
I
N
N
G
-
K
V
---
N
I
N
K
----
V
R
Q
K
-
V
G
M
V
F
Q
H
F
N
L
F
P
H
L
T
A
I
E
N
I
T
L
A
------
P
V
K
V
K
---
K
M
N
K
K
E
A
E
E
L
A
V
D
---
L
---
L
A
K
V
--
G
L
-
L
D
---
K
K
D
Q
Y
P
I
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
N
V
M
K
Q
L
A
N
-
E
-
G
-
M
T
M
V
V
V
T
H
---------------------
14
PsiBlast_PDB
70.05
37%
-33
- C1 -
-
4YMU
1
?
J:
[1-194]
M
I
F
V
N
D
V
Y
K
--
N
F
G
S
-
L
E
V
L
K
--
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
K
G
E
V
F
I
---
D
G
V
K
I
N
N
G
-
K
V
---
N
I
N
K
----
V
R
Q
K
-
V
G
M
V
F
Q
H
F
N
L
F
P
H
L
T
A
I
E
N
I
T
L
A
------
P
V
K
V
K
---
K
M
N
K
K
E
A
E
E
L
A
V
D
---
L
---
L
A
K
V
--
G
L
-
L
D
---
K
K
D
Q
Y
P
I
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
N
V
M
K
Q
L
A
N
-
E
-
G
-
M
T
M
V
V
V
T
H
---------------------
39
PsiBlast_CBE
69.93
34%
-15
- C1 -
-
2PCL
5
LOLD_AQUAE
A:
[19-213]
------------------
I
L
K
--
G
I
S
L
S
V
K
K
G
E
F
V
S
I
I
G
A
S
G
S
G
K
S
T
L
L
Y
I
L
G
L
L
D
A
P
T
E
G
K
V
F
L
---
E
G
K
E
V
D
Y
T
-
N
E
---
K
-
E
L
S
L
--
L
R
N
R
K
L
G
F
V
F
Q
F
H
Y
L
I
P
E
L
T
A
L
E
N
V
I
V
P
------
M
L
K
-
M
---
G
K
P
K
K
E
A
K
E
R
G
E
Y
---
L
---
L
S
E
L
G
L
G
D
--
K
---
L
-
S
R
K
P
Y
E
L
S
G
G
E
Q
Q
R
V
A
I
A
R
A
L
A
N
E
P
I
L
L
F
A
D
E
P
T
G
N
L
D
S
A
N
T
K
R
V
M
D
I
F
L
K
I
N
E
-
G
-
G
-
T
S
I
V
M
V
T
H
E
R
E
L
A
E
-
L
T
H
R
T
L
E
M
K
-----
34
PsiBlast_CBE
69.21
37%
-32
- C1 -
-
4YMV
1
?
A:
[1-194]
M
I
F
V
N
D
V
Y
K
--
N
F
G
S
-
L
E
V
L
K
--
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
K
G
E
V
F
I
---
D
G
V
K
I
N
N
G
-
K
V
---
N
I
N
K
----
V
R
Q
K
-
V
G
M
V
F
Q
H
F
N
L
F
P
H
L
T
A
I
E
N
I
T
L
A
------
P
V
K
V
K
---
K
M
N
K
K
E
A
E
E
L
A
V
D
---
L
---
L
A
K
V
--
G
L
-
L
D
---
K
K
D
Q
Y
P
I
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
N
V
M
K
Q
L
A
N
-
E
-
G
-
M
T
M
V
V
V
T
H
---------------------
108
PsiBlast_CBE
69.16
31%
-3
- C1 -
-
3NH6
2
A:
[54-259]
-
I
E
F
E
N
V
H
F
--
S
Y
A
D
G
R
E
T
L
Q
--
D
V
S
F
T
V
M
P
G
Q
T
L
A
L
V
G
P
S
G
A
G
K
S
T
I
L
R
L
L
F
R
F
Y
D
I
S
S
G
C
I
R
I
---
D
G
Q
D
I
S
Q
V
--
T
---
Q
-
A
S
----
L
R
S
H
-
I
G
V
V
P
Q
D
T
-
V
L
F
N
D
T
I
A
D
N
I
R
Y
G
------
R
V
T
-
A
---
G
N
D
E
V
E
A
A
A
Q
A
A
G
I
H
D
A
---
I
M
A
F
P
E
G
Y
R
T
Q
---
V
-
G
E
R
G
L
K
L
S
G
G
E
K
Q
R
V
A
I
A
R
T
I
L
K
A
P
G
I
I
L
L
D
E
A
T
S
A
L
D
T
S
N
E
R
A
I
Q
A
S
L
A
K
V
C
--
A
-
N
-
R
T
T
I
V
V
A
H
R
L
S
T
V
V
-
N
A
D
Q
I
L
--------
12
PsiBlast_PDB
68.97
37%
-27
- C1 -
-
4YMS
-
?
J:
[1-194]
M
I
F
V
N
D
V
Y
K
--
N
F
G
S
-
L
E
V
L
K
--
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
K
G
E
V
F
I
---
D
G
V
K
I
N
N
G
-
K
V
---
N
I
N
K
----
V
R
Q
K
-
V
G
M
V
F
Q
H
F
N
L
F
P
H
L
T
A
I
E
N
I
T
L
A
------
P
V
K
V
K
---
K
M
N
K
K
E
A
E
E
L
A
V
D
---
L
---
L
A
K
V
--
G
L
-
L
D
---
K
K
D
Q
Y
P
I
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
N
V
M
K
Q
L
A
N
-
E
-
G
-
M
T
M
V
V
V
T
H
---------------------
71
PsiBlast_CBE
68.77
33%
-50
- C1 -
-
1XEF
2
HLYBP_ECOLX
C:
[12-212]
-----------
K
P
D
S
-
P
V
I
L
D
--
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
N
G
Q
V
L
I
---
D
G
H
D
L
-
A
L
-
A
D
---
P
-
N
W
----
L
R
R
Q
-
V
G
V
V
L
Q
D
N
V
L
L
-
N
R
S
I
I
D
N
I
S
L
A
------
N
P
G
-
M
---
S
V
E
K
V
I
Y
A
A
K
L
A
G
---
A
HDF
I
S
E
L
R
E
G
Y
-
N
T
---
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
K
-
G
-
R
-
T
V
I
I
I
A
A
R
L
S
T
V
K
N
--
A
D
R
I
I
V
M
E
K
----
11
PsiBlast_PDB
68.61
35%
-1
- C1 -
-
3TIF
4
Y796_METJA
A:
[24-219]
------------------------
V
N
L
N
I
K
E
G
E
F
V
S
I
M
G
P
S
G
S
G
K
S
T
M
L
N
I
I
G
C
L
D
K
P
T
E
G
E
V
Y
I
DNI
K
T
N
D
L
D
D
D
-
E
L
---
T
-
K
I
----
R
R
D
K
-
I
G
F
V
F
Q
Q
F
N
L
I
P
L
L
T
A
L
E
N
V
E
L
P
------
L
I
F
-
K
---
Y
R
G
A
M
S
G
E
E
R
R
K
R
---
A
---
L
E
C
L
K
M
A
E
-
L
E
ERF
A
-
N
H
K
P
N
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
N
N
P
P
I
I
L
A
D
Q
P
T
W
A
L
D
S
K
T
G
E
K
I
M
Q
L
L
K
K
L
N
E
-
E
-
D
G
K
T
V
V
V
V
T
H
D
I
N
V
A
R
-
F
G
E
R
I
I
Y
L
K
-----
32
PsiBlast_CBE
67.88
34%
50
- C1 -
-
1L2T
3
Y796_METJA
B:
[1-216]
M
I
K
L
K
N
V
T
K
TY
K
M
G
E
-
E
I
I
Y
A
LK
N
V
N
L
N
I
K
E
G
E
F
V
S
I
M
G
P
S
G
S
G
K
S
T
M
L
N
I
I
G
C
L
D
K
P
T
E
G
E
V
Y
I
DNI
K
T
N
D
L
D
D
D
-
E
L
---
T
-
K
I
----
R
R
D
K
-
I
G
F
V
F
Q
Q
F
N
L
I
P
L
L
T
A
L
E
N
V
E
L
P
------
L
I
F
-
K
---
Y
R
G
A
M
S
G
E
E
R
R
K
R
---
A
---
L
E
C
L
K
M
A
E
-
L
E
ERF
A
-
N
H
K
P
N
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
N
N
P
P
I
I
L
A
D
Q
P
T
G
A
L
D
S
K
T
G
E
K
I
M
Q
L
L
K
K
L
N
E
-
E
-
D
G
K
T
V
V
V
V
T
H
D
I
N
V
A
R
-
F
G
E
R
I
I
--------
99
PsiBlast_CBE
65.60
33%
-31
- C1 -
-
4AYW
1
ABCBA_HUMAN
A:
[390-572]
------------------
I
F
Q
--
D
F
S
L
S
I
P
S
G
S
V
T
A
L
V
G
P
S
G
S
G
K
S
T
V
L
S
L
L
L
R
L
Y
D
P
A
S
G
T
I
S
L
---
D
G
H
D
I
R
Q
L
--
N
---
P
-
V
W
----
L
R
S
K
-
I
G
T
V
S
Q
E
-
P
I
L
F
S
C
S
I
A
E
N
I
A
Y
G
ADDPSS
V
T
A
-
E
---
E
I
Q
R
V
A
E
V
A
N
A
V
A
---
F
---
I
R
N
F
P
Q
G
F
N
T
V
---
V
-
G
E
K
G
V
L
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
L
K
N
P
K
I
L
L
L
D
E
----
L
D
A
E
N
E
Y
L
V
Q
E
A
L
D
R
L
M
D
-
G
-
R
-
T
V
L
V
I
A
H
H
---------------------
19
PsiBlast_PDB
64.12
35%
20
- C1 -
-
1F3O
1
Y796_METJA
A:
[24-219]
------------------------
V
N
L
N
I
K
E
G
E
F
V
S
I
M
G
P
S
G
S
G
K
S
T
M
L
N
I
I
G
C
L
D
K
P
T
E
G
E
V
Y
I
DNI
K
T
N
D
L
D
D
D
-
E
L
---
T
-
K
I
----
R
R
D
K
-
I
G
F
V
F
Q
Q
F
N
L
I
P
L
L
T
A
L
E
N
V
E
L
P
------
L
I
F
-
K
YRG
A
M
S
G
E
E
R
R
K
R
A
L
E
---
C
---
L
K
M
A
E
L
E
E
-
R
F
---
A
-
N
H
K
P
N
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
N
N
P
P
I
I
L
A
D
E
P
T
G
A
L
D
S
K
T
G
E
K
I
M
Q
L
L
K
K
L
N
E
-
E
-
D
G
K
T
V
V
V
V
T
H
D
I
N
V
A
R
-
F
G
E
R
I
I
Y
L
K
-----
111
PsiBlast_CBE
63.93
33%
-45
- C1 -
-
4AYX
1
ABCBA_HUMAN
A:
[359-539]
------------------
I
F
Q
--
D
F
S
L
S
I
P
S
G
S
V
T
A
L
V
G
P
S
G
S
G
K
S
T
V
L
S
L
L
L
R
L
Y
D
P
A
S
G
T
I
S
L
---
D
G
H
D
I
R
Q
L
N
P
V
------
W
----
L
R
S
K
-
I
G
T
V
S
Q
E
-
P
I
L
F
S
C
S
I
A
E
N
I
A
Y
G
ADDPSS
V
T
A
-
E
---
E
I
Q
R
V
A
E
V
A
N
A
V
A
---
F
---
I
R
N
F
P
Q
G
F
N
T
V
---
V
-
G
E
K
G
V
L
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
L
K
N
P
K
I
L
L
L
D
E
A
T
S
A
L
D
A
E
N
E
Y
L
V
Q
E
A
L
D
R
L
M
D
-
G
-
R
-
T
V
L
V
I
A
-----------------------
112
PsiBlast_CBE
61.46
33%
-41
- C1 -
-
4AYT
1
ABCBA_HUMAN
A:
[359-539]
------------------
I
F
Q
--
D
F
S
L
S
I
P
S
G
S
V
T
A
L
V
G
P
S
G
S
G
K
S
T
V
L
S
L
L
L
R
L
Y
D
P
A
S
G
T
I
S
L
---
D
G
H
D
I
R
Q
L
N
P
V
------
W
----
L
R
S
K
-
I
G
T
V
S
Q
E
-
P
I
L
F
S
C
S
I
A
E
N
I
A
Y
G
ADDPSS
V
T
A
-
E
---
E
I
Q
R
V
A
E
V
A
N
A
V
A
---
F
---
I
R
N
F
P
Q
G
F
N
T
V
---
V
-
G
E
K
G
V
L
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
L
K
N
P
K
I
L
L
L
D
E
A
T
S
A
L
D
A
E
N
E
Y
L
V
Q
E
A
L
D
R
L
M
D
-
G
-
R
-
T
V
L
V
I
A
-----------------------
60
PsiBlast_CBE
46.96
32%
-
- C1 -
-
3B5Z
2
MSBA_SALTY
A:
[362-549]
------------------------
I
N
L
K
I
P
A
G
K
T
V
A
L
V
G
R
S
G
S
G
K
S
T
I
A
S
L
I
T
R
F
Y
D
I
D
E
G
H
I
L
M
---
D
G
H
D
L
---------
R
-
E
Y
T
L
A
S
L
R
N
Q
-
V
A
L
V
S
Q
N
V
H
L
F
-
N
D
T
V
A
N
N
I
A
Y
A
RTEE--
Y
S
R
-
E
---
Q
I
E
E
A
A
R
M
A
Y
A
M
D
---
F
---
I
N
K
M
D
N
G
--
L
D
TI-
I
-
G
E
N
G
V
L
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
L
R
D
S
P
I
L
I
L
D
E
A
T
S
A
L
D
T
E
-
S
E
R
A
I
Q
A
A
L
D
E
L
Q
-
K
-
N
-
R
T
S
L
V
I
A
H
R
L
S
T
I
E
-
Q
A
D
E
I
V
--------
59
PsiBlast_CBE
46.96
32%
-
- C1 -
-
3B5Z
2
MSBA_SALTY
B:
[362-549]
------------------------
I
N
L
K
I
P
A
G
K
T
V
A
L
V
G
R
S
G
S
G
K
S
T
I
A
S
L
I
T
R
F
Y
D
I
D
E
G
H
I
L
M
---
D
G
H
D
L
---------
R
-
E
Y
TLAS
L
R
N
Q
-
V
A
L
V
S
Q
N
V
H
L
F
-
N
D
T
V
A
N
N
I
A
Y
A
RTEE--
Y
S
R
-
E
---
Q
I
E
E
A
A
R
M
A
Y
A
M
D
---
F
---
I
N
K
M
D
N
G
--
L
D
TI-
I
-
G
E
N
G
V
L
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
L
R
D
S
P
I
L
I
L
D
E
A
T
S
A
L
D
T
E
-
S
E
R
A
I
Q
A
A
L
D
E
L
Q
-
K
-
N
-
R
T
S
L
V
I
A
H
R
L
S
T
I
E
-
Q
A
D
E
I
V
--------
58
PsiBlast_CBE
46.96
32%
-
- C1 -
-
3B5Z
2
MSBA_SALTY
C:
[362-549]
------------------------
I
N
L
K
I
P
A
G
K
T
V
A
L
V
G
R
S
G
S
G
K
S
T
I
A
S
L
I
T
R
F
Y
D
I
D
E
G
H
I
L
M
---
D
G
H
D
L
---------
R
-
E
Y
TLAS
L
R
N
Q
-
V
A
L
V
S
Q
N
V
H
L
F
-
N
D
T
V
A
N
N
I
A
Y
A
RTEE--
Y
S
R
-
E
---
Q
I
E
E
A
A
R
M
A
Y
A
M
D
---
F
---
I
N
K
M
D
N
G
--
L
D
TI-
I
-
G
E
N
G
V
L
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
L
R
D
S
P
I
L
I
L
D
E
A
T
S
A
L
D
T
E
-
S
E
R
A
I
Q
A
A
L
D
E
L
Q
-
K
-
N
-
R
T
S
L
V
I
A
H
R
L
S
T
I
E
-
Q
A
D
E
I
V
--------
57
PsiBlast_CBE
46.95
32%
-
- C1 -
-
3B5Z
2
MSBA_SALTY
D:
[362-549]
------------------------
I
N
L
K
I
P
A
G
K
T
V
A
L
V
G
R
S
G
S
G
K
S
T
I
A
S
L
I
T
R
F
Y
D
I
D
E
G
H
I
L
M
---
D
G
H
D
L
---------
R
-
E
Y
TLAS
L
R
N
Q
-
V
A
L
V
S
Q
N
V
H
L
F
-
N
D
T
V
A
N
N
I
A
Y
A
RTEE--
Y
S
R
-
E
---
Q
I
E
E
A
A
R
M
A
Y
A
M
D
---
F
---
I
N
K
M
D
N
G
--
L
D
TI-
I
-
G
E
N
G
V
L
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
L
R
D
S
P
I
L
I
L
D
E
A
T
S
A
L
D
T
E
-
S
E
R
A
I
Q
A
A
L
D
E
L
Q
-
K
-
N
-
R
T
S
L
V
I
A
H
R
L
S
T
I
E
-
Q
A
D
E
I
V
--------
61
PsiBlast_CBE
46.87
32%
-
- C1 -
-
3B5Y
2
MSBA_SALTY
D:
[362-549]
------------------------
I
N
L
K
I
P
A
G
K
T
V
A
L
V
G
R
S
G
S
G
K
S
T
I
A
S
L
I
T
R
F
Y
D
I
D
E
G
H
I
L
M
---
D
G
H
D
L
---------
R
-
E
Y
TLAS
L
R
N
Q
-
V
A
L
V
S
Q
N
V
H
L
F
-
N
D
T
V
A
N
N
I
A
Y
A
RTEE--
Y
S
R
-
E
---
Q
I
E
E
A
A
R
M
A
Y
A
M
D
---
F
---
I
N
K
M
D
N
G
--
L
D
TI-
I
-
G
E
N
G
V
L
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
L
R
D
S
P
I
L
I
L
D
E
A
T
S
A
L
D
T
E
-
S
E
R
A
I
Q
A
A
L
D
E
L
Q
-
K
-
N
-
R
T
S
L
V
I
A
H
R
L
S
T
I
E
-
Q
A
D
E
I
V
--------
64
PsiBlast_CBE
46.86
32%
-
- C1 -
-
3B5Y
2
MSBA_SALTY
A:
[362-549]
------------------------
I
N
L
K
I
P
A
G
K
T
V
A
L
V
G
R
S
G
S
G
K
S
T
I
A
S
L
I
T
R
F
Y
D
I
D
E
G
H
I
L
M
---
D
G
H
D
L
---------
R
-
E
Y
TL
A
S
L
R
N
Q
-
V
A
L
V
S
Q
N
V
H
L
F
-
N
D
T
V
A
N
N
I
A
Y
A
RTEE--
Y
S
R
-
E
---
Q
I
E
E
A
A
R
M
A
Y
A
M
D
---
F
---
I
N
K
M
D
N
G
--
L
D
T
I
-
I
-
G
E
N
G
V
L
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
L
R
D
S
P
I
L
I
L
D
E
A
T
S
A
L
D
T
E
-
S
E
R
A
I
Q
A
A
L
D
E
L
Q
-
K
-
N
-
R
T
S
L
V
I
A
H
R
L
S
T
I
E
-
Q
A
D
E
I
V
--------
63
PsiBlast_CBE
46.86
32%
-
- C1 -
-
3B5Y
2
MSBA_SALTY
B:
[362-549]
------------------------
I
N
L
K
I
P
A
G
K
T
V
A
L
V
G
R
S
G
S
G
K
S
T
I
A
S
L
I
T
R
F
Y
D
I
D
E
G
H
I
L
M
---
D
G
H
D
L
---------
R
-
E
Y
TLAS
L
R
N
Q
-
V
A
L
V
S
Q
N
V
H
L
F
-
N
D
T
V
A
N
N
I
A
Y
A
RTEE--
Y
S
R
-
E
---
Q
I
E
E
A
A
R
M
A
Y
A
M
D
---
F
---
I
N
K
M
D
N
G
--
L
D
TI-
I
-
G
E
N
G
V
L
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
L
R
D
S
P
I
L
I
L
D
E
A
T
S
A
L
D
T
E
-
S
E
R
A
I
Q
A
A
L
D
E
L
Q
-
K
-
N
-
R
T
S
L
V
I
A
H
R
L
S
T
I
E
-
Q
A
D
E
I
V
--------
62
PsiBlast_CBE
46.86
32%
-
- C1 -
-
3B5Y
2
MSBA_SALTY
C:
[362-549]
------------------------
I
N
L
K
I
P
A
G
K
T
V
A
L
V
G
R
S
G
S
G
K
S
T
I
A
S
L
I
T
R
F
Y
D
I
D
E
G
H
I
L
M
---
D
G
H
D
L
---------
R
-
E
Y
TLAS
L
R
N
Q
-
V
A
L
V
S
Q
N
V
H
L
F
-
N
D
T
V
A
N
N
I
A
Y
A
RTEE--
Y
S
R
-
E
---
Q
I
E
E
A
A
R
M
A
Y
A
M
D
---
F
---
I
N
K
M
D
N
G
--
L
D
TI-
I
-
G
E
N
G
V
L
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
L
R
D
S
P
I
L
I
L
D
E
A
T
S
A
L
D
T
E
-
S
E
R
A
I
Q
A
A
L
D
E
L
Q
-
K
-
N
-
R
T
S
L
V
I
A
H
R
L
S
T
I
E
-
Q
A
D
E
I
V
--------