@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : spr1825: (2018-01-20 )
MICSDSSYSFHNKNFMIFIRRKSLMVVKVGINGFGRIGRLAFRRIQNVEGVEVTRINDLTDPVMLAHLLKYDTTQGRFDGTVEVKEGGFEVNGKFIKVSAERDPEQIDWATDGVEIVLEATGFFAKKEAAEKHLKGGAKKVVITAPGGNDVKTVVFNTNHDVLDGTETVISGASCTTNCLAPMAKALQDNFGVVEGLMTTIHAYTGDQMILDGPHRGGDLRRARAGAANIVPNSTGAAKAIGLVIPELNGKLDGSAQRVPTPTGSVTELVAVLEKNVTVDEVNAAMKAASNESYGYTEDPIVSSDIVGMSYGSLFDATQTKVLDVDGKQLVKVVSWYDNEMSYTAQLVRTLEYFAKIAK
Atome Classification :
(21 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130..-.....140.......150.......160..-.....170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270...-....280.......290.----......300.......310.......320.......330.......340.......350.......
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MICSDSS
Y
S
FHNK
N
F
M
I
F
I
R
RK
S
L
M
V
V
K
VGINGF
G
R
I
G
R
L
A
F
R
R
IQNVEG
V
E
V
T
R
INDLT
D
P
V
M
L
A
H
L
L
KYDTTQGRFD
G
T
V
E
V
KEG
G
F
E
VN
G
K
F
I
K
V
SAERDPEQIDWATD
G
V
E
I
V
L
EATGFF
A
K
K
E
A
A
E
K
H
L-KGGA
K
K
V
V
I
TAPGGN
D
V
K
T
V
V
FNTNHDVLD-G
T
E
T
V
ISGASC
T
T
N
C
L
A
P
M
A
K
A
L
Q
DN
F
G
V
V
E
G
L
M
T
T
I
H
AYTGD
Q
M
I
LDGPHRGG
D
L
R
R
ARAGAANIVPNSTGA
A
K
A
I
G
L
V
IPELNGKLDGSAQRVPTPT
G
S
V
T
E
L
V
A
V
L
E
K-NV
T
V
D
E
V
N
A
A
M
KAASNES----YGYTEDPIVSSDIVGMSYGSLFDAT
Q
T
K
V
LDVD
G
K
Q
L
V
K
V
V
S
W
YDN
E
M
S
Y
T
A
Q
L
V
R
T
L
E
Y
F
A
K
IAK
1
PsiBlast_PDB
88.63
99%
-70
- C6 -
-
5M6D
1
?
A:
[22-355]
-------------------------
V
V
K
V
G
I
N
G
F
G
R
I
G
R
L
A
F
R
R
I
Q
N
V
E
G
V
E
V
T
R
I
N
D
L
T
D
P
V
M
L
A
H
L
L
K
Y
D
T
T
Q
G
R
F
D
G
T
V
E
V
K
E
G
G
F
E
V
N
G
K
F
I
K
V
S
A
E
R
D
P
E
Q
I
D
W
A
T
D
G
V
E
I
V
L
E
A
T
G
F
F
A
K
K
E
A
A
E
K
H
L
-
K
G
G
A
K
K
V
V
I
T
A
P
G
G
N
D
V
K
T
V
V
F
N
T
N
H
D
V
L
D
-
G
T
E
T
V
I
S
G
A
S
-
T
T
N
C
L
A
P
M
A
K
A
L
Q
D
N
F
G
V
V
E
G
L
M
T
T
I
H
A
Y
T
G
D
Q
M
I
L
D
G
P
H
R
G
G
D
L
R
R
A
R
A
G
A
A
N
I
V
P
N
S
T
G
A
A
K
A
I
G
L
V
I
P
E
L
N
G
K
L
D
G
S
A
Q
R
V
P
T
P
T
G
S
V
T
E
L
V
A
V
L
E
K
-
N
V
T
V
D
E
V
N
A
A
M
K
A
A
S
N
E
S
----
Y
G
Y
T
E
D
P
I
V
S
S
D
I
V
G
M
S
Y
G
S
L
F
D
A
T
Q
T
K
V
L
D
V
D
G
K
Q
L
V
K
V
V
S
W
Y
D
N
E
M
S
Y
T
A
Q
L
V
R
T
L
E
Y
F
A
K
I
A
K
24
PsiBlast_CBE
88.58
90%
-78
- C6 -
-
5JY6
2
?
C:
[23-355]
--------------------------
V
K
V
G
I
N
G
F
G
R
I
G
R
L
A
F
R
R
I
Q
N
V
E
G
V
E
V
T
R
I
N
D
L
T
D
P
N
M
L
A
H
L
L
K
Y
D
T
T
Q
G
R
F
D
G
T
V
E
V
K
E
G
G
F
E
V
N
G
Q
F
V
K
V
S
A
E
R
E
P
A
N
I
D
W
A
T
D
G
V
E
I
V
L
E
A
T
G
F
F
A
S
K
E
K
A
E
Q
H
---
N
G
A
K
K
V
V
I
T
A
P
G
G
N
D
V
K
T
V
V
F
N
T
N
H
D
I
L
D
-
G
T
E
T
V
I
S
G
A
S
C
T
T
N
C
L
A
P
M
A
K
A
L
Q
D
N
F
G
V
K
Q
G
L
M
T
T
I
H
A
Y
T
G
D
Q
M
I
L
D
G
P
H
R
G
G
D
L
R
R
A
R
A
G
A
A
N
I
V
P
N
S
T
G
A
A
K
A
I
G
L
V
I
P
E
L
N
G
K
L
D
G
A
A
Q
R
V
P
V
P
T
G
S
V
T
E
L
V
A
T
L
E
K
-
D
V
T
V
E
E
V
N
A
A
M
K
A
A
A
N
D
S
----
Y
G
Y
T
E
D
P
I
V
S
S
D
I
V
G
I
S
Y
G
S
L
F
D
A
T
Q
T
K
V
Q
T
V
D
G
N
Q
L
V
K
V
V
S
W
Y
D
N
E
M
S
Y
T
S
Q
L
V
R
T
L
E
Y
F
A
K
I
A
-
21
PsiBlast_CBE
88.08
99%
-72
- C6 -
-
5M6D
4
?
B:
[22-355]
-------------------------
V
V
K
V
G
I
N
G
F
G
R
I
G
R
L
A
F
R
R
I
Q
N
V
E
G
V
E
V
T
R
I
N
D
L
T
D
P
V
M
L
A
H
L
L
K
Y
D
T
T
Q
G
R
F
D
G
T
V
E
V
K
E
G
G
F
E
V
N
G
K
F
I
K
V
S
A
E
R
D
P
E
Q
I
D
W
A
T
D
G
V
E
I
V
L
E
A
T
G
F
F
A
K
K
E
A
A
E
K
H
L
-
K
G
G
A
K
K
V
V
I
T
A
P
G
G
N
D
V
K
T
V
V
F
N
T
N
H
D
V
L
D
-
G
T
E
T
V
I
S
G
A
S
-
T
T
N
C
L
A
P
M
A
K
A
L
Q
D
N
F
G
V
V
E
G
L
M
T
T
I
H
A
Y
T
G
D
Q
M
I
L
D
G
P
H
R
G
G
D
L
R
R
A
R
A
G
A
A
N
I
V
P
N
S
T
G
A
A
K
A
I
G
L
V
I
P
E
L
N
G
K
L
D
G
S
A
Q
R
V
P
T
P
T
G
S
V
T
E
L
V
A
V
L
E
K
-
N
V
T
V
D
E
V
N
A
A
M
K
A
A
S
N
E
S
----
Y
G
Y
T
E
D
P
I
V
S
S
D
I
V
G
M
S
Y
G
S
L
F
D
A
T
Q
T
K
V
L
D
V
D
G
K
Q
L
V
K
V
V
S
W
Y
D
N
E
M
S
Y
T
A
Q
L
V
R
T
L
E
Y
F
A
K
I
A
K
123
HHSearch
87.62
98%
-67
- C6 -
-
5M6D
1
?
A:
[15-355]
------------------
E
N
L
Y
F
Q
G
V
V
K
V
G
I
N
G
F
G
R
I
G
R
L
A
F
R
R
I
Q
N
V
E
G
V
E
V
T
R
I
N
D
L
T
D
P
V
M
L
A
H
L
L
K
Y
D
T
T
Q
G
R
F
D
G
T
V
E
V
K
E
G
G
F
E
V
N
G
K
F
I
K
V
S
A
E
R
D
P
E
Q
I
D
W
A
T
D
G
V
E
I
V
L
E
A
T
G
F
F
A
K
K
E
A
A
E
K
H
L
-
K
G
G
A
K
K
V
V
I
T
A
P
G
G
N
D
V
K
T
V
V
F
N
T
N
H
D
V
L
D
-
G
T
E
T
V
I
S
G
A
S
-
T
T
N
C
L
A
P
M
A
K
A
L
Q
D
N
F
G
V
V
E
G
L
M
T
T
I
H
A
Y
T
G
D
Q
M
I
L
D
G
P
H
R
G
G
D
L
R
R
A
R
A
G
A
A
N
I
V
P
N
S
T
G
A
A
K
A
I
G
L
V
I
P
E
L
N
G
K
L
D
G
S
A
Q
R
V
P
T
P
T
G
S
V
T
E
L
V
A
V
L
E
K
-
N
V
T
V
D
E
V
N
A
A
M
K
A
A
S
N
E
S
----
Y
G
Y
T
E
D
P
I
V
S
S
D
I
V
G
M
S
Y
G
S
L
F
D
A
T
Q
T
K
V
L
D
V
D
G
K
Q
L
V
K
V
V
S
W
Y
D
N
E
M
S
Y
T
A
Q
L
V
R
T
L
E
Y
F
A
K
I
A
K
35
PsiBlast_CBE
83.00
72%
-80
- C6 -
-
5VMT
2
?
D:
[9-339]
------------------------
M
S
I
K
V
A
I
N
G
F
G
R
I
G
R
L
A
L
R
Q
I
E
K
A
H
G
I
E
V
A
A
V
N
D
L
T
P
A
E
M
L
L
H
L
F
K
Y
D
S
T
Q
G
R
F
Q
G
T
A
E
L
K
D
D
A
I
V
V
N
G
R
E
I
K
V
F
A
N
P
N
P
E
E
L
P
W
G
E
L
G
V
D
V
V
L
E
C
T
G
F
F
T
N
K
T
K
A
E
A
H
I
-
R
A
G
A
R
K
V
V
I
S
A
P
G
G
N
D
V
K
T
V
V
Y
G
V
N
Q
D
I
L
D
-
G
S
E
T
V
I
S
A
A
S
C
T
T
N
C
L
A
P
M
A
A
V
L
Q
K
E
F
G
V
V
E
G
L
M
T
T
I
H
A
Y
T
G
D
Q
N
T
L
D
A
P
H
R
K
G
D
L
R
R
A
R
A
A
A
L
N
I
V
P
N
S
T
G
A
A
K
A
I
G
L
V
I
P
E
L
N
G
K
L
D
G
S
A
Q
R
V
P
V
A
T
G
S
L
T
E
L
V
S
V
L
E
R
-
P
A
T
K
E
E
I
N
A
A
M
K
A
A
S
S
E
S
----
Y
G
Y
N
E
D
Q
I
V
S
S
D
V
V
G
I
E
Y
G
S
L
F
D
A
T
Q
T
R
V
M
T
V
G
G
K
Q
L
V
K
T
V
A
W
Y
D
N
E
M
S
Y
T
C
Q
L
V
R
T
L
E
Y
F
A
----
4
PsiBlast_PDB
82.81
72%
-80
- C6 -
-
5VMT
2
?
A:
[9-339]
------------------------
M
S
I
K
V
A
I
N
G
F
G
R
I
G
R
L
A
L
R
Q
I
E
K
A
H
G
I
E
V
A
A
V
N
D
L
T
P
A
E
M
L
L
H
L
F
K
Y
D
S
T
Q
G
R
F
Q
G
T
A
E
L
K
D
D
A
I
V
V
N
G
R
E
I
K
V
F
A
N
P
N
P
E
E
L
P
W
G
E
L
G
V
D
V
V
L
E
C
T
G
F
F
T
N
K
T
K
A
E
A
H
I
-
R
A
G
A
R
K
V
V
I
S
A
P
G
G
N
D
V
K
T
V
V
Y
G
V
N
Q
D
I
L
D
-
G
S
E
T
V
I
S
A
A
S
C
T
T
N
C
L
A
P
M
A
A
V
L
Q
K
E
F
G
V
V
E
G
L
M
T
T
I
H
A
Y
T
G
D
Q
N
T
L
D
A
P
H
R
K
G
D
L
R
R
A
R
A
A
A
L
N
I
V
P
N
S
T
G
A
A
K
A
I
G
L
V
I
P
E
L
N
G
K
L
D
G
S
A
Q
R
V
P
V
A
T
G
S
L
T
E
L
V
S
V
L
E
R
-
P
A
T
K
E
E
I
N
A
A
M
K
A
A
S
S
E
S
----
Y
G
Y
N
E
D
Q
I
V
S
S
D
V
V
G
I
E
Y
G
S
L
F
D
A
T
Q
T
R
V
M
T
V
G
G
K
Q
L
V
K
T
V
A
W
Y
D
N
E
M
S
Y
T
C
Q
L
V
R
T
L
E
Y
F
A
----
2
PsiBlast_PDB
82.77
90%
-26
- C6 -
-
5JY6
2
?
A:
[22-355]
-------------------------
V
V
K
V
G
I
N
G
F
G
R
I
G
R
L
A
F
R
R
I
Q
N
V
E
G
V
E
V
T
R
I
N
D
L
T
D
P
N
M
L
A
H
L
L
K
Y
D
T
T
Q
G
R
F
D
G
T
V
E
V
K
E
G
G
F
E
V
N
G
Q
F
V
K
V
S
A
E
R
E
P
A
N
I
D
W
A
T
D
G
V
E
I
V
L
E
A
T
G
F
F
A
S
K
E
K
A
E
Q
H
I
H
E
N
G
A
K
K
V
V
I
T
A
P
G
G
N
D
V
K
T
V
V
F
N
T
N
H
D
I
L
D
-
G
T
E
T
V
I
S
G
A
S
C
T
T
N
C
L
A
P
M
A
K
A
L
Q
D
N
F
G
V
K
Q
G
L
M
T
T
I
H
A
Y
T
G
D
Q
M
I
L
D
G
P
H
R
G
G
D
L
R
R
A
R
A
G
A
A
N
I
V
P
N
S
T
G
A
A
K
A
I
G
L
V
I
P
E
L
N
G
K
L
D
G
A
A
Q
R
V
P
V
P
T
G
S
V
T
E
L
V
A
T
L
E
K
-
D
V
T
V
E
E
V
N
A
A
M
K
A
A
A
N
D
S
----
Y
G
Y
T
E
D
P
I
V
S
S
D
I
V
G
I
S
Y
G
S
L
F
D
A
T
Q
T
K
V
Q
T
V
D
G
N
Q
L
V
K
V
V
S
W
Y
D
N
E
M
S
Y
T
S
Q
L
V
R
T
L
E
Y
F
A
K
I
A
-
32
PsiBlast_CBE
82.68
72%
-85
- C6 -
-
5VMT
2
?
H:
[10-339]
-------------------------
S
I
K
V
A
I
N
G
F
G
R
I
G
R
L
A
L
R
Q
I
E
K
A
H
G
I
E
V
A
A
V
N
D
L
T
P
A
E
M
L
L
H
L
F
K
Y
D
S
T
Q
G
R
F
Q
G
T
A
E
L
K
D
D
A
I
V
V
N
G
R
E
I
K
V
F
A
N
P
N
P
E
E
L
P
W
G
E
L
G
V
D
V
V
L
E
C
T
G
F
F
T
N
K
T
K
A
E
A
H
I
-
R
A
G
A
R
K
V
V
I
S
A
P
G
G
N
D
V
K
T
V
V
Y
G
V
N
Q
D
I
L
D
-
G
S
E
T
V
I
S
A
A
S
C
T
T
N
C
L
A
P
M
A
A
V
L
Q
K
E
F
G
V
V
E
G
L
M
T
T
I
H
A
Y
T
G
D
Q
N
T
L
D
A
P
H
R
K
G
D
L
R
R
A
R
A
A
A
L
N
I
V
P
N
S
T
G
A
A
K
A
I
G
L
V
I
P
E
L
N
G
K
L
D
G
S
A
Q
R
V
P
V
A
T
G
S
L
T
E
L
V
S
V
L
E
R
-
P
A
T
K
E
E
I
N
A
A
M
K
A
A
S
S
E
S
----
Y
G
Y
N
E
D
Q
I
V
S
S
D
V
V
G
I
E
Y
G
S
L
F
D
A
T
Q
T
R
V
M
T
V
G
G
K
Q
L
V
K
T
V
A
W
Y
D
N
E
M
S
Y
T
C
Q
L
V
R
T
L
E
Y
F
A
----
28
PsiBlast_CBE
82.34
90%
-23
- C6 -
-
4QX6
2
?
B:
[22-356]
-------------------------
V
V
K
V
G
I
N
G
F
G
R
I
G
R
L
A
F
R
R
I
Q
N
V
E
G
V
E
V
T
R
I
N
D
L
T
D
P
N
M
L
A
H
L
L
K
Y
D
T
T
Q
G
R
F
D
G
T
V
E
V
K
E
G
G
F
E
V
N
G
Q
F
V
K
V
S
A
E
R
E
P
A
N
I
D
W
A
T
D
G
V
E
I
V
L
E
A
T
G
F
F
A
S
K
E
K
A
E
Q
H
I
H
E
N
G
A
K
K
V
V
I
T
A
P
G
G
N
D
V
K
T
V
V
F
N
T
N
H
D
I
L
D
-
G
T
E
T
V
I
S
G
A
S
C
T
T
N
C
L
A
P
M
A
K
A
L
Q
D
N
F
G
V
K
Q
G
L
M
T
T
I
H
A
Y
T
G
D
Q
M
I
L
D
G
P
H
R
G
G
D
L
R
R
A
R
A
G
A
A
N
I
V
P
N
S
T
G
A
A
K
A
I
G
L
V
I
P
E
L
N
G
K
L
D
G
A
A
Q
R
V
P
V
P
T
G
S
V
T
E
L
V
A
T
L
E
K
-
D
V
T
V
E
E
V
N
A
A
M
K
A
A
A
N
D
S
----
Y
G
Y
T
E
D
P
I
V
S
S
D
I
V
G
I
S
Y
G
S
L
F
D
A
T
Q
T
K
V
Q
T
V
D
G
N
Q
L
V
K
V
V
S
W
Y
D
N
E
M
S
Y
T
S
Q
L
V
R
T
L
E
Y
F
A
K
I
A
K
23
PsiBlast_CBE
82.15
90%
-25
- C6 -
-
5JY6
2
?
D:
[23-355]
--------------------------
V
K
V
G
I
N
G
F
G
R
I
G
R
L
A
F
R
R
I
Q
N
V
E
G
V
E
V
T
R
I
N
D
L
T
D
P
N
M
L
A
H
L
L
K
Y
D
T
T
Q
G
R
F
D
G
T
V
E
V
K
E
G
G
F
E
V
N
G
Q
F
V
K
V
S
A
E
R
E
P
A
N
I
D
W
A
T
D
G
V
E
I
V
L
E
A
T
G
F
F
A
S
K
E
K
A
E
Q
H
I
H
E
N
G
A
K
K
V
V
I
T
A
P
G
G
N
D
V
K
T
V
V
F
N
T
N
H
D
I
L
D
-
G
T
E
T
V
I
S
G
A
S
C
T
T
N
C
L
A
P
M
A
K
A
L
Q
D
N
F
G
V
K
Q
G
L
M
T
T
I
H
A
Y
T
G
D
Q
M
I
L
D
G
P
H
R
G
G
D
L
R
R
A
R
A
G
A
A
N
I
V
P
N
S
T
G
A
A
K
A
I
G
L
V
I
P
E
L
N
G
K
L
D
G
A
A
Q
R
V
P
V
P
T
G
S
V
T
E
L
V
A
T
L
E
K
-
D
V
T
V
E
E
V
N
A
A
M
K
A
A
A
N
D
S
----
Y
G
Y
T
E
D
P
I
V
S
S
D
I
V
G
I
S
Y
G
S
L
F
D
A
T
Q
T
K
V
Q
T
V
D
G
N
Q
L
V
K
V
V
S
W
Y
D
N
E
M
S
Y
T
S
Q
L
V
R
T
L
E
Y
F
A
K
I
A
-
27
PsiBlast_CBE
81.78
90%
-24
- C6 -
-
4QX6
4
?
C:
[22-355]
-------------------------
V
V
K
V
G
I
N
G
F
G
R
I
G
R
L
A
F
R
R
I
Q
N
V
E
G
V
E
V
T
R
I
N
D
L
T
D
P
N
M
L
A
H
L
L
K
Y
D
T
T
Q
G
R
F
D
G
T
V
E
V
K
E
G
G
F
E
V
N
G
Q
F
V
K
V
S
A
E
R
E
P
A
N
I
D
W
A
T
D
G
V
E
I
V
L
E
A
T
G
F
F
A
S
K
E
K
A
E
Q
H
I
H
E
N
G
A
K
K
V
V
I
T
A
P
G
G
N
D
V
K
T
V
V
F
N
T
N
H
D
I
L
D
-
G
T
E
T
V
I
S
G
A
S
C
T
T
N
C
L
A
P
M
A
K
A
L
Q
D
N
F
G
V
K
Q
G
L
M
T
T
I
H
A
Y
T
G
D
Q
M
I
L
D
G
P
H
R
G
G
D
L
R
R
A
R
A
G
A
A
N
I
V
P
N
S
T
G
A
A
K
A
I
G
L
V
I
P
E
L
N
G
K
L
D
G
A
A
Q
R
V
P
V
P
T
G
S
V
T
E
L
V
A
T
L
E
K
-
D
V
T
V
E
E
V
N
A
A
M
K
A
A
A
N
D
S
----
Y
G
Y
T
E
D
P
I
V
S
S
D
I
V
G
I
S
Y
G
S
L
F
D
A
T
Q
T
K
V
Q
T
V
D
G
N
Q
L
V
K
V
V
S
W
Y
D
N
E
M
S
Y
T
S
Q
L
V
R
T
L
E
Y
F
A
K
I
A
-
22
PsiBlast_CBE
81.69
90%
-26
- C6 -
-
5JYE
2
?
C:
[22-355]
-------------------------
V
V
K
V
G
I
N
G
F
G
R
I
G
R
L
A
F
R
R
I
Q
N
V
E
G
V
E
V
T
R
I
N
D
L
T
D
P
N
M
L
A
H
L
L
K
Y
D
T
T
Q
G
R
F
D
G
T
V
E
V
K
E
G
G
F
E
V
N
G
Q
F
V
K
V
S
A
E
R
E
P
A
N
I
D
W
A
T
D
G
V
E
I
V
L
E
A
T
G
F
F
A
S
K
E
K
A
E
Q
H
I
H
E
N
G
A
K
K
V
V
I
T
A
P
G
G
N
D
V
K
T
V
V
F
N
T
N
H
D
I
L
D
-
G
T
E
T
V
I
S
G
A
S
C
T
T
N
C
L
A
P
M
A
K
A
L
Q
D
N
F
G
V
K
Q
G
L
M
T
T
I
H
A
Y
T
G
D
Q
M
I
L
D
G
P
H
R
G
G
D
L
R
R
A
R
A
G
A
A
N
I
V
P
N
S
T
G
A
A
K
A
I
G
L
V
I
P
E
L
N
G
K
L
D
G
A
A
Q
R
V
P
V
P
T
G
S
V
T
E
L
V
A
T
L
E
K
-
D
V
T
V
E
E
V
N
A
A
M
K
A
A
A
N
D
S
----
Y
G
Y
T
E
D
P
I
V
S
S
D
I
V
G
I
S
Y
G
S
L
F
D
A
T
Q
T
K
V
Q
T
V
D
G
N
Q
L
V
K
V
V
S
W
Y
D
N
E
M
S
Y
T
S
Q
L
V
R
T
L
E
Y
F
A
K
I
A
-
25
PsiBlast_CBE
81.63
90%
-23
- C6 -
-
5JY6
2
?
B:
[22-356]
-------------------------
V
V
K
V
G
I
N
G
F
G
R
I
G
R
L
A
F
R
R
I
Q
N
V
E
G
V
E
V
T
R
I
N
D
L
T
D
P
N
M
L
A
H
L
L
K
Y
D
T
T
Q
G
R
F
D
G
T
V
E
V
K
E
G
G
F
E
V
N
G
Q
F
V
K
V
S
A
E
R
E
P
A
N
I
D
W
A
T
D
G
V
E
I
V
L
E
A
T
G
F
F
A
S
K
E
K
A
E
Q
H
I
H
E
N
G
A
K
K
V
V
I
T
A
P
G
G
N
D
V
K
T
V
V
F
N
T
N
H
D
I
L
D
-
G
T
E
T
V
I
S
G
A
S
C
T
T
N
C
L
A
P
M
A
K
A
L
Q
D
N
F
G
V
K
Q
G
L
M
T
T
I
H
A
Y
T
G
D
Q
M
I
L
D
G
P
H
R
G
G
D
L
R
R
A
R
A
G
A
A
N
I
V
P
N
S
T
G
A
A
K
A
I
G
L
V
I
P
E
L
N
G
K
L
D
G
A
A
Q
R
V
P
V
P
T
G
S
V
T
E
L
V
A
T
L
E
K
-
D
V
T
V
E
E
V
N
A
A
M
K
A
A
A
N
D
S
----
Y
G
Y
T
E
D
P
I
V
S
S
D
I
V
G
I
S
Y
G
S
L
F
D
A
T
Q
T
K
V
Q
T
V
D
G
N
Q
L
V
K
V
V
S
W
Y
D
N
E
M
S
Y
T
S
Q
L
V
R
T
L
E
Y
F
A
K
I
A
K
26
PsiBlast_CBE
81.59
90%
-23
- C6 -
-
4QX6
3
?
D:
[14-356]
-----------------
L
V
P
R
G
S
H
M
V
V
K
V
G
I
N
G
F
G
R
I
G
R
L
A
F
R
R
I
Q
N
V
E
G
V
E
V
T
R
I
N
D
L
T
D
P
N
M
L
A
H
L
L
K
Y
D
T
T
Q
G
R
F
D
G
T
V
E
V
K
E
G
G
F
E
V
N
G
Q
F
V
K
V
S
A
E
R
E
P
A
N
I
D
W
A
T
D
G
V
E
I
V
L
E
A
T
G
F
F
A
S
K
E
K
A
E
Q
H
I
H
E
N
G
A
K
K
V
V
I
T
A
P
G
G
N
D
V
K
T
V
V
F
N
T
N
H
D
I
L
D
-
G
T
E
T
V
I
S
G
A
S
C
T
T
N
C
L
A
P
M
A
K
A
L
Q
D
N
F
G
V
K
Q
G
L
M
T
T
I
H
A
Y
T
G
D
Q
M
I
L
D
G
P
H
R
G
G
D
L
R
R
A
R
A
G
A
A
N
I
V
P
N
S
T
G
A
A
K
A
I
G
L
V
I
P
E
L
N
G
K
L
D
G
A
A
Q
R
V
P
V
P
T
G
S
V
T
E
L
V
A
T
L
E
K
-
D
V
T
V
E
E
V
N
A
A
M
K
A
A
A
N
D
S
----
Y
G
Y
T
E
D
P
I
V
S
S
D
I
V
G
I
S
Y
G
S
L
F
D
A
T
Q
T
K
V
Q
T
V
D
G
N
Q
L
V
K
V
V
S
W
Y
D
N
E
M
S
Y
T
S
Q
L
V
R
T
L
E
Y
F
A
K
I
A
K
34
PsiBlast_CBE
81.12
72%
-80
- C6 -
-
5VMT
2
?
F:
[9-339]
------------------------
M
S
I
K
V
A
I
N
G
F
G
R
I
G
R
L
A
L
R
Q
I
E
K
A
H
G
I
E
V
A
A
V
N
D
L
T
P
A
E
M
L
L
H
L
F
K
Y
D
S
T
Q
G
R
F
Q
G
T
A
E
L
K
D
D
A
I
V
V
N
G
R
E
I
K
V
F
A
N
P
N
P
E
E
L
P
W
G
E
L
G
V
D
V
V
L
E
C
T
G
F
F
T
N
K
T
K
A
E
A
H
I
-
R
A
G
A
R
K
V
V
I
S
A
P
G
G
N
D
V
K
T
V
V
Y
G
V
N
Q
D
I
L
D
-
G
S
E
T
V
I
S
A
A
S
C
T
T
N
C
L
A
P
M
A
A
V
L
Q
K
E
F
G
V
V
E
G
L
M
T
T
I
H
A
Y
T
G
D
Q
N
T
L
D
A
P
H
R
K
G
D
L
R
R
A
R
A
A
A
L
N
I
V
P
N
S
T
G
A
A
K
A
I
G
L
V
I
P
E
L
N
G
K
L
D
G
S
A
Q
R
V
P
V
A
T
G
S
L
T
E
L
V
S
V
L
E
R
-
P
A
T
K
E
E
I
N
A
A
M
K
A
A
S
S
E
S
----
Y
G
Y
N
E
D
Q
I
V
S
S
D
V
V
G
I
E
Y
G
S
L
F
D
A
T
Q
T
R
V
M
T
V
G
G
K
Q
L
V
K
T
V
A
W
Y
D
N
E
M
S
Y
T
C
Q
L
V
R
T
L
E
Y
F
A
----
37
PsiBlast_CBE
80.65
72%
-77
- C6 -
-
5VMT
2
?
B:
[9-339]
------------------------
M
S
I
K
V
A
I
N
G
F
G
R
I
G
R
L
A
L
R
Q
I
E
K
A
H
G
I
E
V
A
A
V
N
D
L
T
P
A
E
M
L
L
H
L
F
K
Y
D
S
T
Q
G
R
F
Q
G
T
A
E
L
K
D
D
A
I
V
V
N
G
R
E
I
K
V
F
A
N
P
N
P
E
E
L
P
W
G
E
L
G
V
D
V
V
L
E
C
T
G
F
F
T
N
K
T
K
A
E
A
H
I
-
R
A
G
A
R
K
V
V
I
S
A
P
G
G
N
D
V
K
T
V
V
Y
G
V
N
Q
D
I
L
D
-
G
S
E
T
V
I
S
A
A
S
C
T
T
N
C
L
A
P
M
A
A
V
L
Q
K
E
F
G
V
V
E
G
L
M
T
T
I
H
A
Y
T
G
D
Q
N
T
L
D
A
P
H
R
K
G
D
L
R
R
A
R
A
A
A
L
N
I
V
P
N
S
T
G
A
A
K
A
I
G
L
V
I
P
E
L
N
G
K
L
D
G
S
A
Q
R
V
P
V
A
T
G
S
L
T
E
L
V
S
V
L
E
R
-
P
A
T
K
E
E
I
N
A
A
M
K
A
A
S
S
E
S
----
Y
G
Y
N
E
D
Q
I
V
S
S
D
V
V
G
I
E
Y
G
S
L
F
D
A
T
Q
T
R
V
M
T
V
G
G
K
Q
L
V
K
T
V
A
W
Y
D
N
E
M
S
Y
T
C
Q
L
V
R
T
L
E
Y
F
A
----
31
PsiBlast_CBE
80.48
90%
-27
- C6 -
-
5JYA
3
?
B:
[22-355]
-------------------------
V
V
K
V
G
I
N
G
F
G
R
I
G
R
L
A
F
R
R
I
Q
N
V
E
G
V
E
V
T
R
I
N
D
L
T
D
P
N
M
L
A
H
L
L
K
Y
D
T
T
Q
G
R
F
D
G
T
V
E
V
K
E
G
G
F
E
V
N
G
Q
F
V
K
V
S
A
E
R
E
P
A
N
I
D
W
A
T
D
G
V
E
I
V
L
E
A
T
G
F
F
A
S
K
E
K
A
E
Q
H
I
H
E
N
G
A
K
K
V
V
I
T
A
P
G
G
N
D
V
K
T
V
V
F
N
T
N
H
D
I
L
D
-
G
T
E
T
V
I
S
G
A
S
S
T
T
N
C
L
A
P
M
A
K
A
L
Q
D
N
F
G
V
K
Q
G
L
M
T
T
I
H
A
Y
T
G
D
Q
M
I
L
D
G
P
H
R
G
G
D
L
R
R
A
R
A
G
A
A
N
I
V
P
N
S
T
G
A
A
--
I
G
L
V
I
P
E
L
N
G
K
L
D
G
A
A
Q
R
V
P
V
P
T
G
S
V
T
E
L
V
A
T
L
E
K
-
D
V
T
V
E
E
V
N
A
A
M
K
A
A
A
N
D
S
----
Y
G
Y
T
E
D
P
I
V
S
S
D
I
V
G
I
S
Y
G
S
L
F
D
A
T
Q
T
K
V
Q
T
V
D
G
N
Q
L
V
K
V
V
S
W
Y
D
N
E
M
S
Y
T
S
Q
L
V
R
T
L
E
Y
F
A
K
I
A
-
3
PsiBlast_PDB
80.38
90%
-25
- C6 -
-
5JYE
2
?
A:
[22-355]
-------------------------
V
V
K
V
G
I
N
G
F
G
R
I
G
R
L
A
F
R
R
I
Q
N
V
E
G
V
E
V
T
R
I
N
D
L
T
D
P
N
M
L
A
H
L
L
K
Y
D
T
T
Q
G
R
F
D
G
T
V
E
V
K
E
G
G
F
E
V
N
G
Q
F
V
K
V
S
A
E
R
E
P
A
N
I
D
W
A
T
D
G
V
E
I
V
L
E
A
T
G
F
F
A
S
K
E
K
A
E
Q
H
I
H
E
N
G
A
K
K
V
V
I
T
A
P
G
G
N
D
V
K
T
V
V
F
N
T
N
H
D
I
L
D
-
G
T
E
T
V
I
S
G
A
S
C
T
T
N
C
L
A
P
M
A
K
A
L
Q
D
N
F
G
V
K
Q
G
L
M
T
T
I
H
A
Y
T
G
D
Q
M
I
L
D
G
P
H
R
G
G
D
L
R
R
A
R
A
G
A
A
N
I
V
P
N
S
T
G
A
A
K
A
I
G
L
V
I
P
E
L
N
G
K
L
D
G
A
A
Q
R
V
P
V
P
T
G
S
V
T
E
L
V
A
T
L
E
K
-
D
V
T
V
E
E
V
N
A
A
M
K
A
A
A
N
D
S
----
Y
G
Y
T
E
D
P
I
V
S
S
D
I
V
G
I
S
Y
G
S
L
F
D
A
T
Q
T
K
V
Q
T
V
D
G
N
Q
L
V
K
V
V
S
W
Y
D
N
E
M
S
Y
T
S
Q
L
V
R
T
L
E
Y
F
A
K
I
A
-
40
PsiBlast_CBE
80.31
69%
-58
- C6 -
-
3LC2
1
G3P1_STAAR
P:
[1-334]
------------------------
M
A
V
K
V
A
I
N
G
F
G
R
I
G
R
L
A
F
R
R
I
Q
E
V
E
G
L
E
V
V
A
V
N
D
L
T
D
D
D
M
L
A
H
L
L
K
Y
D
T
M
Q
G
R
F
T
G
E
V
E
V
V
D
G
G
F
R
V
N
G
K
E
V
K
S
F
S
E
P
D
A
S
K
L
P
W
K
D
L
N
I
D
V
V
L
E
C
T
G
F
Y
T
D
K
D
K
A
Q
A
H
I
-
E
A
G
A
K
K
V
L
I
S
A
P
A
T
G
D
L
K
T
I
V
F
N
T
N
H
Q
E
L
D
-
G
S
E
T
V
V
S
G
A
S
C
T
T
N
S
L
A
P
V
A
K
V
L
N
D
D
F
G
L
V
E
G
L
M
T
T
I
H
A
Y
T
G
D
Q
N
T
Q
D
A
P
H
R
K
G
D
K
R
R
A
R
A
A
A
E
N
I
I
P
N
S
T
G
A
A
K
A
I
G
K
V
I
P
E
I
D
G
K
L
D
G
G
A
Q
R
V
P
V
A
T
G
S
L
T
E
L
T
V
V
L
E
K
Q
D
V
T
V
E
Q
V
N
E
A
M
K
N
A
S
N
E
S
----
F
G
Y
T
E
D
E
I
V
S
S
D
V
V
G
M
T
Y
G
S
L
F
D
A
T
Q
T
R
V
M
S
V
G
D
R
Q
L
V
K
V
A
A
W
Y
D
N
E
M
S
Y
T
A
Q
L
V
R
T
L
A
Y
L
A
E
L
--
6
PsiBlast_PDB
80.28
69%
-57
- C6 -
-
3L6O
-
G3P1_STAAR
Q:
[1-334]
------------------------
M
A
V
K
V
A
I
N
G
F
G
R
I
G
R
L
A
F
R
R
I
Q
E
V
E
G
L
E
V
V
A
V
N
D
L
T
D
D
D
M
L
A
H
L
L
K
Y
D
T
M
Q
G
R
F
T
G
E
V
E
V
V
D
G
G
F
R
V
N
G
K
E
V
K
S
F
S
E
P
D
A
S
K
L
P
W
K
D
L
N
I
D
V
V
L
E
C
T
G
F
Y
T
D
K
D
K
A
Q
A
H
I
-
E
A
G
A
K
K
V
L
I
S
A
P
A
T
G
D
L
K
T
I
V
F
N
T
N
H
Q
E
L
D
-
G
S
E
T
V
V
S
G
A
S
C
T
T
N
S
L
A
P
V
A
K
V
L
N
D
D
F
G
L
V
E
G
L
M
T
T
I
H
A
Y
T
G
D
Q
N
T
Q
D
A
P
H
R
K
G
D
K
R
R
A
R
A
A
A
E
N
I
I
P
N
S
T
G
A
A
K
A
I
G
K
V
I
P
E
I
D
G
K
L
D
G
G
A
Q
R
V
P
V
A
T
G
S
L
T
E
L
T
V
V
L
E
K
Q
D
V
T
V
E
Q
V
N
E
A
M
K
N
A
S
N
E
S
----
F
G
Y
T
E
D
E
I
V
S
S
D
V
V
G
M
T
Y
G
S
L
F
D
A
T
Q
T
R
V
M
S
V
G
D
R
Q
L
V
K
V
A
A
W
Y
D
N
E
M
S
Y
T
A
Q
L
V
R
T
L
A
Y
L
A
E
L
--
83
PsiBlast_CBE
72.90
56%
-35
- C6 -
-
3CMC
8
G3P_GEOSE
R:
[2-330]
--------------------------
V
K
V
G
I
N
G
F
G
R
I
G
R
N
V
F
R
A
A
L
K
N
P
D
I
E
V
V
A
V
N
D
L
T
D
A
N
T
L
A
H
L
L
K
Y
D
S
V
H
G
R
L
D
A
E
V
S
V
N
G
N
N
L
V
V
N
G
K
E
I
I
V
K
A
E
R
D
P
E
N
L
A
W
G
E
I
G
V
D
I
V
V
E
S
T
G
R
F
T
K
R
E
D
A
A
K
H
L
-
E
A
G
A
K
K
V
I
I
S
A
P
A
K
N
E
D
I
T
I
V
M
G
V
N
Q
D
K
Y
D
P
K
A
H
H
V
I
S
N
A
S
C
T
T
N
C
L
A
P
F
A
K
V
L
H
E
Q
F
G
I
V
R
G
M
M
T
T
V
H
S
Y
T
N
D
Q
R
I
L
D
L
P
H
K
--
D
L
R
R
A
R
A
A
A
E
S
I
I
P
T
T
T
G
A
A
K
A
V
A
L
V
L
P
E
L
K
G
K
L
N
G
M
A
M
R
V
P
T
P
N
V
S
V
V
D
L
V
A
E
L
E
K
-
E
V
T
V
E
E
V
N
A
A
L
K
A
A
A
E
G
E
LKGI
L
A
Y
S
E
E
P
L
V
S
R
D
Y
N
G
S
T
V
S
S
T
I
D
A
L
S
T
M
V
--
I
D
G
K
-
M
V
K
V
V
S
W
Y
D
N
E
T
G
Y
S
H
R
V
V
D
L
A
A
Y
I
A
----