@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : spr1846: (2018-01-21 )
MKNLRIALISKDWIWKVRKRNKEMTKRIPNLQVALDHSDLQGAIKAAVSVGQEVDIIEAGTVCLLQVGSELAEVLRSLFPDKIIVADTKCADAGGTVAKNNAVRGADWMTCICCATIPTMEAALKAIKTERGERGEIQIELYGDWTFEQAQLWLDAGISQAIYHQSRDALLAGETWGEKDLNKVKKLIDMGFRVSVTGGLDVDTLKLFEGVDVFTFIAGRGITEAADPAGAARAFKDEIKRIWG
Atome Classification :
(35 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.---......140.......150.......160.......170.......180.......190.......200.......210...--....220.......230.......240..
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MKN
L
R
I
A
L
ISK
D
W
I
W
K
V
R
KR
N
K
E
M
T
K
RIPN
L
Q
V
A
LD
H
S
D
L
Q
G
A
I
K
A
A
V
SVGQ
E
V
D
I
I
EA
G
T
V
C
L
L
Q
V
G
S
E
L
A
E
V
L
R
S
LFPD
K
I
I
V
A
DTKCADAGGTVAKNNAVRGA
D
W
M
T
C
I
CCATI
P
T
M
E
A
A
L
K
A
I
K
TERGE---R
G
E
I
Q
I
E
L
Y
GDW
T
F
E
Q
A
Q
L
W
L
D
AG
I
S
Q
A
I
Y
HQSRD
A
L
LAGETW
G
E
K
D
L
N
K
V
K
K
L
I
DMG
F
R
V
S
VTGGLD
V
D
T
L
K
L
FEGV
D
V
F
T
--
F
I
AGRGITEAADPA
G
A
A
R
A
F
K
D
E
I
K
R
IWG
21
PsiBlast_CBE
89.62
88%
-121
- C4 -
-
3EXS
1
?
D:
[4-221]
--------------------------
Q
L
P
N
L
Q
V
A
L
D
H
S
N
L
K
G
A
I
T
A
A
V
S
V
G
N
E
V
D
V
I
E
A
G
T
V
C
L
L
Q
V
G
S
E
L
V
E
V
L
R
S
L
F
P
D
K
I
I
V
A
D
T
K
C
A
D
A
G
G
T
V
A
K
N
N
A
V
R
G
A
D
W
M
T
C
I
C
S
A
T
I
P
T
M
K
A
A
R
K
A
I
E
D
I
N
P
D
---
K
G
E
I
Q
V
E
L
Y
G
D
W
T
Y
D
Q
A
Q
Q
W
L
D
A
G
I
S
Q
A
I
Y
H
Q
S
R
D
A
L
L
A
G
E
T
W
G
E
K
D
L
N
K
V
K
K
L
I
E
M
G
F
R
V
S
V
T
G
G
L
S
V
D
T
L
K
L
F
E
G
V
D
V
F
T
--
F
I
A
G
R
G
I
T
E
A
K
N
P
A
G
A
A
R
A
F
K
D
E
I
K
R
I
W
G
2
PsiBlast_PDB
88.43
88%
-125
- C4 -
-
3EXS
1
?
A:
[5-221]
---------------------------
L
P
N
L
Q
V
A
L
D
H
S
N
L
K
G
A
I
T
A
A
V
S
V
G
N
E
V
D
V
I
E
A
G
T
V
C
L
L
Q
V
G
S
E
L
V
E
V
L
R
S
L
F
P
D
K
I
I
V
A
D
T
K
C
A
D
A
G
G
T
V
A
K
N
N
A
V
R
G
A
D
W
M
T
C
I
C
S
A
T
I
P
T
M
K
A
A
R
K
A
I
E
D
I
N
P
D
---
K
G
E
I
Q
V
E
L
Y
G
D
W
T
Y
D
Q
A
Q
Q
W
L
D
A
G
I
S
Q
A
I
Y
H
Q
S
R
---------
G
E
K
D
L
N
K
V
K
K
L
I
E
M
G
F
R
V
S
V
T
G
G
L
S
V
D
T
L
K
L
F
E
G
V
D
V
F
T
--
F
I
A
G
R
G
I
T
E
A
K
N
P
A
G
A
A
R
A
F
K
D
E
I
K
R
I
W
G
3
PsiBlast_PDB
87.71
88%
-126
- C4 -
-
3EXT
-
?
A:
[4-221]
--------------------------
Q
L
P
N
L
Q
V
A
L
D
H
S
N
L
K
G
A
I
T
A
A
V
S
V
G
N
E
V
D
V
I
E
A
G
T
V
C
L
L
Q
V
G
S
E
L
V
E
V
L
R
S
L
F
P
D
K
I
I
V
A
D
T
K
C
A
D
A
G
G
T
V
A
K
N
N
A
V
R
G
A
D
W
M
T
C
I
C
S
A
T
I
P
T
M
K
A
A
R
K
A
I
E
D
I
N
P
D
---
K
G
E
I
Q
V
E
L
Y
G
D
W
T
Y
D
Q
A
Q
Q
W
L
D
A
G
I
S
Q
A
I
Y
H
Q
S
R
-------
T
W
G
E
K
D
L
N
K
V
K
K
L
I
E
M
G
F
R
V
S
V
T
G
G
L
S
V
D
T
L
K
L
F
E
G
V
D
V
F
T
--
F
I
A
G
R
G
I
T
E
A
K
N
P
A
G
A
A
R
A
F
K
D
E
I
K
R
I
W
G
23
PsiBlast_CBE
87.02
88%
-127
- C4 -
-
3EXS
1
?
B:
[4-221]
--------------------------
Q
L
P
N
L
Q
V
A
L
D
H
S
N
L
K
G
A
I
T
A
A
V
S
V
G
N
E
V
D
V
I
E
A
G
T
V
C
L
L
Q
V
G
S
E
L
V
E
V
L
R
S
L
F
P
D
K
I
I
V
A
D
T
K
C
A
D
A
G
G
T
V
A
K
N
N
A
V
R
G
A
D
W
M
T
C
I
C
S
A
T
I
P
T
M
K
A
A
R
K
A
I
E
D
I
N
P
D
---
K
G
E
I
Q
V
E
L
Y
G
D
W
T
Y
D
Q
A
Q
Q
W
L
D
A
G
I
S
Q
A
I
Y
H
Q
S
R
-------
T
W
G
E
K
D
L
N
K
V
K
K
L
I
E
M
G
F
R
V
S
V
T
G
G
L
S
V
D
T
L
K
L
F
E
G
V
D
V
F
T
--
F
I
A
G
R
G
I
T
E
A
K
N
P
A
G
A
A
R
A
F
K
D
E
I
K
R
I
W
G
22
PsiBlast_CBE
86.33
88%
-120
- C4 -
-
3EXS
1
?
C:
[5-221]
---------------------------
L
P
N
L
Q
V
A
L
D
H
S
N
L
K
G
A
I
T
A
A
V
S
V
G
N
E
V
D
V
I
E
A
G
T
V
C
L
L
Q
V
G
S
E
L
V
E
V
L
R
S
L
F
P
D
K
I
I
V
A
D
T
K
C
A
D
A
G
G
T
V
A
K
N
N
A
V
R
G
A
D
W
M
T
C
I
C
S
A
T
I
P
T
M
K
A
A
R
K
A
I
E
D
I
N
P
D
---
K
G
E
I
Q
V
E
L
Y
G
D
W
T
Y
D
Q
A
Q
Q
W
L
D
A
G
I
S
Q
A
I
Y
H
Q
S
R
---------
G
E
K
D
L
N
K
V
K
K
L
I
E
M
G
F
R
V
S
V
T
G
G
L
S
V
D
T
L
K
L
F
E
G
V
D
V
F
T
--
F
I
A
G
R
G
I
T
E
A
K
N
P
A
G
A
A
R
A
F
K
D
E
I
K
R
I
W
G
1
PsiBlast_PDB
83.80
88%
-
- C4 -
-
3EXR
-
?
A:
[3-221]
-------------------------
K
Q
L
P
N
L
Q
V
A
L
D
H
S
N
L
K
G
A
I
T
A
A
V
S
V
G
N
E
V
D
V
I
E
A
G
T
V
C
L
L
Q
V
G
S
E
L
V
E
V
L
R
S
L
F
P
D
K
I
I
V
A
D
T
K
C
A
D
A
G
G
T
V
A
K
N
N
A
V
R
G
A
D
W
M
T
C
I
C
S
A
T
I
P
T
M
K
A
A
R
K
A
I
E
D
I
N
P
D
---
K
G
E
I
Q
V
E
L
Y
G
D
W
T
Y
D
Q
A
Q
Q
W
L
D
A
G
I
S
Q
A
I
Y
H
Q
S
R
D
A
L
L
A
G
E
T
W
G
E
K
D
L
N
K
V
K
K
L
I
E
M
G
F
R
V
S
V
T
G
G
L
S
V
D
T
L
K
L
F
E
G
V
D
V
F
T
--
F
I
A
G
R
G
I
T
E
A
K
N
P
A
G
A
A
R
A
F
K
D
E
I
K
R
I
W
G
49
HHSearch
81.76
87%
-
- C4 -
-
3EXR
-
?
A:
[3-221]
-------------------------
K
Q
L
P
N
L
Q
V
A
L
D
H
S
N
L
K
G
A
I
T
A
A
V
S
V
G
N
E
V
D
V
I
E
A
G
T
V
C
L
L
Q
V
G
S
E
L
V
E
V
L
R
S
L
F
P
D
K
I
I
V
A
D
T
K
C
A
D
A
G
G
T
V
A
K
N
N
A
V
R
G
A
D
W
M
T
C
I
C
S
A
T
I
P
T
M
K
A
A
R
K
A
I
E
D
---
I
N
PD
K
G
E
I
Q
V
E
L
Y
G
D
W
T
Y
D
Q
A
Q
Q
W
L
D
A
G
I
S
Q
A
I
Y
H
Q
S
R
D
A
L
L
A
G
E
T
W
G
E
K
D
L
N
K
V
K
K
L
I
E
M
G
F
R
V
S
V
T
G
G
L
S
V
D
T
L
K
L
F
--
E
G
V
D
V
F
T
F
I
A
G
R
G
I
T
E
A
K
N
P
A
G
A
A
R
A
F
K
D
E
I
K
R
I
W
G
48
HHSearch
78.27
87%
-
- C4 -
-
3EXR
-
?
C:
[4-221]
--------------------------
Q
L
P
N
L
Q
V
A
L
D
H
S
N
L
K
G
A
I
T
A
A
V
S
V
G
N
E
V
D
V
I
E
A
G
T
V
C
L
L
Q
V
G
S
E
L
V
E
V
L
R
S
L
F
P
D
K
I
I
V
A
D
T
K
C
A
D
A
G
G
T
V
A
K
N
N
A
V
R
G
A
D
W
M
T
C
I
C
S
A
T
I
P
T
M
K
A
A
R
K
A
I
E
D
---
I
N
PD
K
G
E
I
Q
V
E
L
Y
G
D
W
T
Y
D
Q
A
Q
Q
W
L
D
A
G
I
S
Q
A
I
Y
H
Q
S
R
-------
T
W
G
E
K
D
L
N
K
V
K
K
L
I
E
M
G
F
R
V
S
V
T
G
G
L
S
V
D
T
L
K
L
F
--
E
G
V
D
V
F
T
F
I
A
G
R
G
I
T
E
A
K
N
P
A
G
A
A
R
A
F
K
D
E
I
K
R
I
W
G
27
PsiBlast_CBE
77.76
48%
-134
- C4 -
-
1Q6O
2
ULAD_ECOLI
B:
[3-216]
---------------------------
L
P
M
L
Q
V
A
L
D
N
Q
T
M
D
S
A
Y
E
T
T
R
L
I
A
E
E
V
D
I
I
E
V
G
T
I
L
C
V
G
E
G
V
R
A
V
R
D
L
K
A
L
Y
P
H
K
I
V
L
A
D
A
K
I
A
D
A
G
K
I
L
S
R
M
C
F
E
A
N
A
D
W
V
T
V
I
C
C
A
D
I
N
T
A
K
G
A
L
D
V
A
K
E
F
N
G
D
------
V
Q
I
E
L
T
G
Y
W
T
W
E
Q
A
Q
Q
W
R
D
A
G
I
G
Q
V
V
Y
H
R
S
R
D
A
Q
A
A
G
V
A
W
G
E
A
D
I
T
A
I
K
R
L
S
D
M
G
F
K
V
T
V
T
G
G
L
A
L
E
D
L
P
L
F
K
G
I
P
I
H
V
--
F
I
A
G
R
S
I
R
D
A
A
S
P
V
E
A
A
R
Q
F
K
R
S
I
A
E
L
W
G
61
HHSearch
77.56
47%
-132
* C4 *
-
1XBZ
2
ULAD_ECOLI
B:
[2-216]
--------------------------
S
L
P
M
L
Q
V
A
L
D
N
Q
T
M
D
S
A
Y
E
T
T
R
L
I
A
E
E
V
D
I
I
E
V
G
T
I
L
C
V
G
E
G
V
R
A
V
R
D
L
K
A
L
Y
P
H
K
I
V
L
A
D
A
K
I
A
D
A
G
K
I
L
S
R
M
C
F
E
A
N
A
D
W
V
T
V
I
C
C
A
D
I
N
T
A
K
G
A
L
D
V
A
K
E
---
F
---
N
G
D
V
Q
I
D
L
T
G
Y
W
T
W
E
Q
A
Q
Q
W
R
D
A
G
I
G
Q
V
V
Y
H
R
S
V
D
A
Q
A
A
G
V
A
W
G
E
A
D
I
T
A
I
K
R
L
S
D
M
G
F
K
V
T
V
A
G
G
L
A
L
E
D
L
P
L
F
K
G
I
P
I
H
V
--
F
I
A
G
R
S
I
R
D
A
A
S
P
V
E
A
A
R
Q
F
K
R
S
I
A
E
L
W
G
36
PsiBlast_CBE
77.38
47%
-133
- C4 -
-
1XBZ
2
ULAD_ECOLI
B:
[3-216]
---------------------------
L
P
M
L
Q
V
A
L
D
N
Q
T
M
D
S
A
Y
E
T
T
R
L
I
A
E
E
V
D
I
I
E
V
G
T
I
L
C
V
G
E
G
V
R
A
V
R
D
L
K
A
L
Y
P
H
K
I
V
L
A
D
A
K
I
A
D
A
G
K
I
L
S
R
M
C
F
E
A
N
A
D
W
V
T
V
I
C
C
A
D
I
N
T
A
K
G
A
L
D
V
A
K
E
F
N
G
D
------
V
Q
I
D
L
T
G
Y
W
T
W
E
Q
A
Q
Q
W
R
D
A
G
I
G
Q
V
V
Y
H
R
S
V
D
A
Q
A
A
G
V
A
W
G
E
A
D
I
T
A
I
K
R
L
S
D
M
G
F
K
V
T
V
A
G
G
L
A
L
E
D
L
P
L
F
K
G
I
P
I
H
V
--
F
I
A
G
R
S
I
R
D
A
A
S
P
V
E
A
A
R
Q
F
K
R
S
I
A
E
L
W
G
24
PsiBlast_CBE
77.28
48%
-135
- C4 -
-
1XBV
2
ULAD_ECOLI
B:
[3-216]
---------------------------
L
P
M
L
Q
V
A
L
D
N
Q
T
M
D
S
A
Y
E
T
T
R
L
I
A
E
E
V
D
I
I
E
V
G
T
I
L
C
V
G
E
G
V
R
A
V
R
D
L
K
A
L
Y
P
H
K
I
V
L
A
D
A
K
I
A
D
A
G
K
I
L
S
R
M
C
F
E
A
N
A
D
W
V
T
V
I
C
C
A
D
I
N
T
A
K
G
A
L
D
V
A
K
E
F
N
G
D
------
V
Q
I
E
L
T
G
Y
W
T
W
E
Q
A
Q
Q
W
R
D
A
G
I
G
Q
V
V
Y
H
R
S
R
D
A
Q
A
A
G
V
A
W
G
E
A
D
I
T
A
I
K
R
L
S
D
M
G
F
K
V
T
V
T
G
G
L
A
L
E
D
L
P
L
F
K
G
I
P
I
H
V
--
F
I
A
G
R
S
I
R
D
A
A
S
P
V
E
A
A
R
Q
F
K
R
S
I
A
E
L
W
G
9
PsiBlast_PDB
76.84
48%
-133
- C4 -
-
1Q6R
2
ULAD_ECOLI
A:
[3-215]
---------------------------
L
P
M
L
Q
V
A
L
D
N
Q
T
M
D
S
A
Y
E
T
T
R
L
I
A
E
E
V
D
I
I
E
V
G
T
I
L
C
V
G
E
G
V
R
A
V
R
D
L
K
A
L
Y
P
H
K
I
V
L
A
D
A
K
I
A
D
A
G
K
I
L
S
R
M
C
F
E
A
N
A
D
W
V
T
V
I
C
C
A
D
I
N
T
A
K
G
A
L
D
V
A
K
E
F
N
G
D
------
V
Q
I
E
L
T
G
Y
W
T
W
E
Q
A
Q
Q
W
R
D
A
G
I
G
Q
V
V
Y
H
R
S
R
D
A
Q
A
A
G
V
A
W
G
E
A
D
I
T
A
I
K
R
L
S
D
M
G
F
K
V
T
V
T
G
G
L
A
L
E
D
L
P
L
F
K
G
I
P
I
H
V
--
F
I
A
G
R
S
I
R
D
A
A
S
P
V
E
A
A
R
Q
F
K
R
S
I
A
E
L
W
-
25
PsiBlast_CBE
76.48
48%
-131
- C4 -
-
1Q6R
2
ULAD_ECOLI
B:
[3-216]
---------------------------
L
P
M
L
Q
V
A
L
D
N
Q
T
M
D
S
A
Y
E
T
T
R
L
I
A
E
E
V
D
I
I
E
V
G
T
I
L
C
V
G
E
G
V
R
A
V
R
D
L
K
A
L
Y
P
H
K
I
V
L
A
D
A
K
I
A
D
A
G
K
I
L
S
R
M
C
F
E
A
N
A
D
W
V
T
V
I
C
C
A
D
I
N
T
A
K
G
A
L
D
V
A
K
E
F
N
G
D
------
V
Q
I
E
L
T
G
Y
W
T
W
E
Q
A
Q
Q
W
R
D
A
G
I
G
Q
V
V
Y
H
R
S
R
D
A
Q
A
A
G
V
A
W
G
E
A
D
I
T
A
I
K
R
L
S
D
M
G
F
K
V
T
V
T
G
G
L
A
L
E
D
L
P
L
F
K
G
I
P
I
H
V
--
F
I
A
G
R
S
I
R
D
A
A
S
P
V
E
A
A
R
Q
F
K
R
S
I
A
E
L
W
G
32
PsiBlast_CBE
76.31
47%
-138
- C4 -
-
1SO4
2
ULAD_ECOLI
B:
[3-216]
---------------------------
L
P
M
L
Q
V
A
L
D
N
Q
T
M
D
S
A
Y
E
T
T
R
L
I
A
E
E
V
D
I
I
E
V
G
T
I
L
C
V
G
E
G
V
R
A
V
R
D
L
K
A
L
Y
P
H
K
I
V
L
A
D
A
A
I
A
D
A
G
K
I
L
S
R
M
C
F
E
A
N
A
D
W
V
T
V
I
C
C
A
D
I
N
T
A
K
G
A
L
D
V
A
K
E
F
N
G
D
------
V
Q
I
E
L
T
G
Y
W
T
W
E
Q
A
Q
Q
W
R
D
A
G
I
G
Q
V
V
Y
H
R
S
R
D
A
Q
A
A
G
V
A
W
G
E
A
D
I
T
A
I
K
R
L
S
D
M
G
F
K
V
T
V
T
G
G
L
A
L
E
D
L
P
L
F
K
G
I
P
I
H
V
--
F
I
A
G
R
S
I
R
D
A
A
S
P
V
E
A
A
R
Q
F
K
R
S
I
A
E
L
W
G
31
PsiBlast_CBE
76.31
47%
-130
- C4 -
-
1SO5
2
ULAD_ECOLI
B:
[3-216]
---------------------------
L
P
M
L
Q
V
A
L
D
N
Q
T
M
D
S
A
Y
E
T
T
R
L
I
A
E
E
V
D
I
I
E
V
G
T
I
L
C
V
G
E
G
V
R
A
V
R
D
L
K
A
L
Y
P
H
K
I
V
L
A
D
A
K
I
A
D
A
G
K
I
L
S
R
M
C
F
E
A
N
A
D
W
V
T
V
I
C
C
A
D
I
N
T
A
K
G
A
L
D
V
A
K
E
F
N
G
D
------
V
Q
I
Q
L
T
G
Y
W
T
W
E
Q
A
Q
Q
W
R
D
A
G
I
G
Q
V
V
Y
H
R
S
R
D
A
Q
A
A
G
V
A
W
G
E
A
D
I
T
A
I
K
R
L
S
D
M
G
F
K
V
T
V
T
G
G
L
A
L
E
D
L
P
L
F
K
G
I
P
I
H
V
--
F
I
A
G
R
S
I
R
D
A
A
S
P
V
E
A
A
R
Q
F
K
R
S
I
A
E
L
W
G
12
PsiBlast_PDB
76.23
47%
-137
- C4 -
-
1SO4
2
ULAD_ECOLI
A:
[3-215]
---------------------------
L
P
M
L
Q
V
A
L
D
N
Q
T
M
D
S
A
Y
E
T
T
R
L
I
A
E
E
V
D
I
I
E
V
G
T
I
L
C
V
G
E
G
V
R
A
V
R
D
L
K
A
L
Y
P
H
K
I
V
L
A
D
A
A
I
A
D
A
G
K
I
L
S
R
M
C
F
E
A
N
A
D
W
V
T
V
I
C
C
A
D
I
N
T
A
K
G
A
L
D
V
A
K
E
F
N
G
D
------
V
Q
I
E
L
T
G
Y
W
T
W
E
Q
A
Q
Q
W
R
D
A
G
I
G
Q
V
V
Y
H
R
S
R
D
A
Q
A
A
G
V
A
W
G
E
A
D
I
T
A
I
K
R
L
S
D
M
G
F
K
V
T
V
T
G
G
L
A
L
E
D
L
P
L
F
K
G
I
P
I
H
V
--
F
I
A
G
R
S
I
R
D
A
A
S
P
V
E
A
A
R
Q
F
K
R
S
I
A
E
L
W
-
11
PsiBlast_PDB
76.21
47%
-131
- C4 -
-
1SO5
2
ULAD_ECOLI
A:
[3-215]
---------------------------
L
P
M
L
Q
V
A
L
D
N
Q
T
M
D
S
A
Y
E
T
T
R
L
I
A
E
E
V
D
I
I
E
V
G
T
I
L
C
V
G
E
G
V
R
A
V
R
D
L
K
A
L
Y
P
H
K
I
V
L
A
D
A
K
I
A
D
A
G
K
I
L
S
R
M
C
F
E
A
N
A
D
W
V
T
V
I
C
C
A
D
I
N
T
A
K
G
A
L
D
V
A
K
E
F
N
G
D
------
V
Q
I
Q
L
T
G
Y
W
T
W
E
Q
A
Q
Q
W
R
D
A
G
I
G
Q
V
V
Y
H
R
S
R
D
A
Q
A
A
G
V
A
W
G
E
A
D
I
T
A
I
K
R
L
S
D
M
G
F
K
V
T
V
T
G
G
L
A
L
E
D
L
P
L
F
K
G
I
P
I
H
V
--
F
I
A
G
R
S
I
R
D
A
A
S
P
V
E
A
A
R
Q
F
K
R
S
I
A
E
L
W
-
33
PsiBlast_CBE
76.13
47%
-131
- C4 -
-
1XBY
2
ULAD_ECOLI
B:
[3-216]
---------------------------
L
P
M
L
Q
V
A
L
D
N
Q
T
M
D
S
A
Y
E
T
T
R
L
I
A
E
E
V
D
I
I
E
V
G
T
I
L
C
V
G
E
G
V
R
A
V
R
D
L
K
A
L
Y
P
H
K
I
V
L
A
D
A
K
I
A
D
A
G
K
I
L
S
R
M
C
F
E
A
N
A
D
W
V
T
V
I
C
C
A
D
I
N
T
A
K
G
A
L
D
V
A
K
E
F
N
G
D
------
V
Q
I
D
L
T
G
Y
W
T
W
E
Q
A
Q
Q
W
R
D
A
G
I
G
Q
V
V
Y
H
R
S
R
D
A
Q
A
A
G
V
A
W
G
E
A
D
I
T
A
I
K
R
L
S
D
M
G
F
K
V
T
V
A
G
G
L
A
L
E
D
L
P
L
F
K
G
I
P
I
H
V
--
F
I
A
G
R
S
I
R
D
A
A
S
P
V
E
A
A
R
Q
F
K
R
S
I
A
E
L
W
G
28
PsiBlast_CBE
76.04
48%
-133
- C4 -
-
1Q6L
2
ULAD_ECOLI
B:
[3-216]
---------------------------
L
P
M
L
Q
V
A
L
D
N
Q
T
M
D
S
A
Y
E
T
T
R
L
I
A
E
E
V
D
I
I
E
V
G
T
I
L
C
V
G
E
G
V
R
A
V
R
D
L
K
A
L
Y
P
H
K
I
V
L
A
D
A
K
I
A
D
A
G
K
I
L
S
R
M
C
F
E
A
N
A
D
W
V
T
V
I
C
C
A
D
I
N
T
A
K
G
A
L
D
V
A
K
E
F
N
G
D
------
V
Q
I
E
L
T
G
Y
W
T
W
E
Q
A
Q
Q
W
R
D
A
G
I
G
Q
V
V
Y
H
R
S
R
D
A
Q
A
A
G
V
A
W
G
E
A
D
I
T
A
I
K
R
L
S
D
M
G
F
K
V
T
V
T
G
G
L
A
L
E
D
L
P
L
F
K
G
I
P
I
H
V
--
F
I
A
G
R
S
I
R
D
A
A
S
P
V
E
A
A
R
Q
F
K
R
S
I
A
E
L
W
G
10
PsiBlast_PDB
76.01
48%
-130
- C4 -
-
1XBV
2
ULAD_ECOLI
A:
[3-215]
---------------------------
L
P
M
L
Q
V
A
L
D
N
Q
T
M
D
S
A
Y
E
T
T
R
L
I
A
E
E
V
D
I
I
E
V
G
T
I
L
C
V
G
E
G
V
R
A
V
R
D
L
K
A
L
Y
P
H
K
I
V
L
A
D
A
K
I
A
D
A
G
K
I
L
S
R
M
C
F
E
A
N
A
D
W
V
T
V
I
C
C
A
D
I
N
T
A
K
G
A
L
D
V
A
K
E
F
N
G
D
------
V
Q
I
E
L
T
G
Y
W
T
W
E
Q
A
Q
Q
W
R
D
A
G
I
G
Q
V
V
Y
H
R
S
R
D
A
Q
A
A
G
V
A
W
G
E
A
D
I
T
A
I
K
R
L
S
D
M
G
F
K
V
T
V
T
G
G
L
A
L
E
D
L
P
L
F
K
G
I
P
I
H
V
--
F
I
A
G
R
S
I
R
D
A
A
S
P
V
E
A
A
R
Q
F
K
R
S
I
A
E
L
W
-
14
PsiBlast_PDB
76.00
47%
-129
- C4 -
-
1SO3
2
ULAD_ECOLI
A:
[3-215]
---------------------------
L
P
M
L
Q
V
A
L
D
N
Q
T
M
D
S
A
Y
E
T
T
R
L
I
A
E
E
V
D
I
I
E
V
G
T
I
L
C
V
G
E
G
V
R
A
V
R
D
L
K
A
L
Y
P
H
K
I
V
L
A
D
A
K
I
A
D
A
G
K
I
L
S
R
M
C
F
E
A
N
A
D
W
V
T
V
I
C
C
A
D
I
N
T
A
K
G
A
L
D
V
A
K
E
F
N
G
D
------
V
Q
I
E
L
T
G
Y
W
T
W
E
Q
A
Q
Q
W
R
D
A
G
I
G
Q
V
V
Y
A
R
S
R
D
A
Q
A
A
G
V
A
W
G
E
A
D
I
T
A
I
K
R
L
S
D
M
G
F
K
V
T
V
T
G
G
L
A
L
E
D
L
P
L
F
K
G
I
P
I
H
V
--
F
I
A
G
R
S
I
R
D
A
A
S
P
V
E
A
A
R
Q
F
K
R
S
I
A
E
L
W
-
5
PsiBlast_PDB
75.98
48%
-135
- C4 -
-
1KW1
2
ULAD_ECOLI
A:
[3-215]
---------------------------
L
P
M
L
Q
V
A
L
D
N
Q
T
M
D
S
A
Y
E
T
T
R
L
I
A
E
E
V
D
I
I
E
V
G
T
I
L
C
V
G
E
G
V
R
A
V
R
D
L
K
A
L
Y
P
H
K
I
V
L
A
D
A
K
I
A
D
A
G
K
I
L
S
R
M
C
F
E
A
N
A
D
W
V
T
V
I
C
C
A
D
I
N
T
A
K
G
A
L
D
V
A
K
E
F
N
G
D
------
V
Q
I
E
L
T
G
Y
W
T
W
E
Q
A
Q
Q
W
R
D
A
G
I
G
Q
V
V
Y
H
R
S
R
D
A
Q
A
A
G
V
A
W
G
E
A
D
I
T
A
I
K
R
L
S
D
M
G
F
K
V
T
V
T
G
G
L
A
L
E
D
L
P
L
F
K
G
I
P
I
H
V
--
F
I
A
G
R
S
I
R
D
A
A
S
P
V
E
A
A
R
Q
F
K
R
S
I
A
E
L
W
-
34
PsiBlast_CBE
75.77
47%
-139
- C4 -
-
1SO3
2
ULAD_ECOLI
B:
[3-216]
---------------------------
L
P
M
L
Q
V
A
L
D
N
Q
T
M
D
S
A
Y
E
T
T
R
L
I
A
E
E
V
D
I
I
E
V
G
T
I
L
C
V
G
E
G
V
R
A
V
R
D
L
K
A
L
Y
P
H
K
I
V
L
A
D
A
K
I
A
D
A
G
K
I
L
S
R
M
C
F
E
A
N
A
D
W
V
T
V
I
C
C
A
D
I
N
T
A
K
G
A
L
D
V
A
K
E
F
N
G
D
------
V
Q
I
E
L
T
G
Y
W
T
W
E
Q
A
Q
Q
W
R
D
A
G
I
G
Q
V
V
Y
A
R
S
R
D
A
Q
A
A
G
V
A
W
G
E
A
D
I
T
A
I
K
R
L
S
D
M
G
F
K
V
T
V
T
G
G
L
A
L
E
D
L
P
L
F
K
G
I
P
I
H
V
--
F
I
A
G
R
S
I
R
D
A
A
S
P
V
E
A
A
R
Q
F
K
R
S
I
A
E
L
W
G
29
PsiBlast_CBE
75.71
48%
-134
- C4 -
-
1KW1
2
ULAD_ECOLI
B:
[3-216]
---------------------------
L
P
M
L
Q
V
A
L
D
N
Q
T
M
D
S
A
Y
E
T
T
R
L
I
A
E
E
V
D
I
I
E
V
G
T
I
L
C
V
G
E
G
V
R
A
V
R
D
L
K
A
L
Y
P
H
K
I
V
L
A
D
A
K
I
A
D
A
G
K
I
L
S
R
M
C
F
E
A
N
A
D
W
V
T
V
I
C
C
A
D
I
N
T
A
K
G
A
L
D
V
A
K
E
F
N
G
D
------
V
Q
I
E
L
T
G
Y
W
T
W
E
Q
A
Q
Q
W
R
D
A
G
I
G
Q
V
V
Y
H
R
S
R
D
A
Q
A
A
G
V
A
W
G
E
A
D
I
T
A
I
K
R
L
S
D
M
G
F
K
V
T
V
T
G
G
L
A
L
E
D
L
P
L
F
K
G
I
P
I
H
V
--
F
I
A
G
R
S
I
R
D
A
A
S
P
V
E
A
A
R
Q
F
K
R
S
I
A
E
L
W
G
26
PsiBlast_CBE
75.66
48%
-133
- C4 -
-
1Q6Q
2
ULAD_ECOLI
B:
[3-215]
---------------------------
L
P
M
L
Q
V
A
L
D
N
Q
T
M
D
S
A
Y
E
T
T
R
L
I
A
E
E
V
D
I
I
E
V
G
T
I
L
C
V
G
E
G
V
R
A
V
R
D
L
K
A
L
Y
P
H
K
I
V
L
A
D
A
K
I
A
D
A
G
K
I
L
S
R
M
C
F
E
A
N
A
D
W
V
T
V
I
C
C
A
D
I
N
T
A
K
G
A
L
D
V
A
K
E
F
N
G
D
------
V
Q
I
E
L
T
G
Y
W
T
W
E
Q
A
Q
Q
W
R
D
A
G
I
G
Q
V
V
Y
H
R
S
R
D
A
Q
A
A
G
V
A
W
G
E
A
D
I
T
A
I
K
R
L
S
D
M
G
F
K
V
T
V
T
G
G
L
A
L
E
D
L
P
L
F
K
G
I
P
I
H
V
--
F
I
A
G
R
S
I
R
D
A
A
S
P
V
E
A
A
R
Q
F
K
R
S
I
A
E
L
W
-
13
PsiBlast_PDB
75.56
47%
-130
- C4 -
-
1XBY
2
ULAD_ECOLI
A:
[3-215]
---------------------------
L
P
M
L
Q
V
A
L
D
N
Q
T
M
D
S
A
Y
E
T
T
R
L
I
A
E
E
V
D
I
I
E
V
G
T
I
L
C
V
G
E
G
V
R
A
V
R
D
L
K
A
L
Y
P
H
K
I
V
L
A
D
A
K
I
A
D
A
G
K
I
L
S
R
M
C
F
E
A
N
A
D
W
V
T
V
I
C
C
A
D
I
N
T
A
K
G
A
L
D
V
A
K
E
F
N
G
D
------
V
Q
I
D
L
T
G
Y
W
T
W
E
Q
A
Q
Q
W
R
D
A
G
I
G
Q
V
V
Y
H
R
S
R
D
A
Q
A
A
G
V
A
W
G
E
A
D
I
T
A
I
K
R
L
S
D
M
G
F
K
V
T
V
A
G
G
L
A
L
E
D
L
P
L
F
K
G
I
P
I
H
V
--
F
I
A
G
R
S
I
R
D
A
A
S
P
V
E
A
A
R
Q
F
K
R
S
I
A
E
L
W
-
35
PsiBlast_CBE
75.55
47%
-138
- C4 -
-
1SO6
2
ULAD_ECOLI
B:
[3-216]
---------------------------
L
P
M
L
Q
V
A
L
D
N
Q
T
M
D
S
A
Y
E
T
T
R
L
I
A
E
E
V
D
I
I
E
V
G
T
I
L
C
V
G
E
G
V
R
A
V
R
D
L
K
A
L
Y
P
H
K
I
V
L
A
D
A
K
I
A
D
A
G
K
I
L
S
R
M
C
F
E
A
N
A
D
W
V
T
V
I
C
C
A
D
I
N
T
A
K
G
A
L
D
V
A
K
E
F
N
G
D
------
V
Q
I
Q
L
T
G
Y
W
T
W
E
Q
A
Q
Q
W
R
D
A
G
I
G
Q
V
V
Y
A
R
S
R
D
A
Q
A
A
G
V
A
W
G
E
A
D
I
T
A
I
K
R
L
S
D
M
G
F
K
V
T
V
T
G
G
L
A
L
E
D
L
P
L
F
K
G
I
P
I
H
V
--
F
I
A
G
R
S
I
R
D
A
A
S
P
V
E
A
A
R
Q
F
K
R
S
I
A
E
L
W
G
16
PsiBlast_PDB
75.47
47%
-134
- C4 -
-
1XBX
2
ULAD_ECOLI
A:
[3-215]
---------------------------
L
P
M
L
Q
V
A
L
D
N
Q
T
M
D
S
A
Y
E
T
T
R
L
I
A
E
E
V
D
I
I
E
V
G
T
I
L
C
V
G
E
G
V
R
A
V
R
D
L
K
A
L
Y
P
H
K
I
V
L
A
D
A
K
I
A
D
A
G
K
I
L
S
R
M
C
F
E
A
N
A
D
W
V
T
V
I
C
C
A
D
I
N
T
A
K
G
A
L
D
V
A
K
E
F
N
G
D
------
V
Q
I
D
L
T
G
Y
W
T
W
E
Q
A
Q
Q
W
R
D
A
G
I
G
Q
V
V
Y
H
R
S
V
D
A
Q
A
A
G
V
A
W
G
E
A
D
I
T
A
I
K
R
L
S
D
M
G
F
K
V
T
V
A
G
G
L
A
L
E
D
L
P
L
F
K
G
I
P
I
H
V
--
F
I
A
G
R
S
I
R
D
A
A
S
P
V
E
A
A
R
Q
F
K
R
S
I
A
E
L
W
-
15
PsiBlast_PDB
75.46
47%
-133
- C4 -
-
1SO6
2
ULAD_ECOLI
A:
[3-216]
---------------------------
L
P
M
L
Q
V
A
L
D
N
Q
T
M
D
S
A
Y
E
T
T
R
L
I
A
E
E
V
D
I
I
E
V
G
T
I
L
C
V
G
E
G
V
R
A
V
R
D
L
K
A
L
Y
P
H
K
I
V
L
A
D
A
K
I
A
D
A
G
K
I
L
S
R
M
C
F
E
A
N
A
D
W
V
T
V
I
C
C
A
D
I
N
T
A
K
G
A
L
D
V
A
K
E
F
N
G
D
------
V
Q
I
Q
L
T
G
Y
W
T
W
E
Q
A
Q
Q
W
R
D
A
G
I
G
Q
V
V
Y
A
R
S
R
D
A
Q
A
A
G
V
A
W
G
E
A
D
I
T
A
I
K
R
L
S
D
M
G
F
K
V
T
V
T
G
G
L
A
L
E
D
L
P
L
F
K
G
I
P
I
H
V
--
F
I
A
G
R
S
I
R
D
A
A
S
P
V
E
A
A
R
Q
F
K
R
S
I
A
E
L
W
G
8
PsiBlast_PDB
75.38
48%
-137
- C4 -
-
1Q6Q
2
ULAD_ECOLI
A:
[3-215]
---------------------------
L
P
M
L
Q
V
A
L
D
N
Q
T
M
D
S
A
Y
E
T
T
R
L
I
A
E
E
V
D
I
I
E
V
G
T
I
L
C
V
G
E
G
V
R
A
V
R
D
L
K
A
L
Y
P
H
K
I
V
L
A
D
A
K
I
A
D
A
G
K
I
L
S
R
M
C
F
E
A
N
A
D
W
V
T
V
I
C
C
A
D
I
N
T
A
K
G
A
L
D
V
A
K
E
F
N
G
D
------
V
Q
I
E
L
T
G
Y
W
T
W
E
Q
A
Q
Q
W
R
D
A
G
I
G
Q
V
V
Y
H
R
S
R
D
A
Q
A
A
-
V
A
W
G
E
A
D
I
T
A
I
K
R
L
S
D
M
G
F
K
V
T
V
T
G
G
L
A
L
E
D
L
P
L
F
K
G
I
P
I
H
V
--
F
I
A
G
R
S
I
R
D
A
A
S
P
V
E
A
A
R
Q
F
K
R
S
I
A
E
L
W
-
37
PsiBlast_CBE
75.14
47%
-134
- C4 -
-
1XBX
2
ULAD_ECOLI
B:
[3-216]
---------------------------
L
P
M
L
Q
V
A
L
D
N
Q
T
M
D
S
A
Y
E
T
T
R
L
I
A
E
E
V
D
I
I
E
V
G
T
I
L
C
V
G
E
G
V
R
A
V
R
D
L
K
A
L
Y
P
H
K
I
V
L
A
D
A
K
I
A
D
A
G
K
I
L
S
R
M
C
F
E
A
N
A
D
W
V
T
V
I
C
C
A
D
I
N
T
A
K
G
A
L
D
V
A
K
E
F
N
G
D
------
V
Q
I
D
L
T
G
Y
W
T
W
E
Q
A
Q
Q
W
R
D
A
G
I
G
Q
V
V
Y
H
R
S
V
D
A
Q
A
A
G
V
A
W
G
E
A
D
I
T
A
I
K
R
L
S
D
M
G
F
K
V
T
V
A
G
G
L
A
L
E
D
L
P
L
F
K
G
I
P
I
H
V
--
F
I
A
G
R
S
I
R
D
A
A
S
P
V
E
A
A
R
Q
F
K
R
S
I
A
E
L
W
G
51
HHSearch
74.87
41%
-136
- C4 -
-
3IEB
4
?
B:
[5-218]
--------------------------
T
K
P
M
I
Q
I
A
L
D
Q
T
N
L
T
D
A
V
A
V
A
S
N
V
A
S
Y
V
D
V
I
E
V
G
T
I
L
A
F
A
E
G
M
K
A
V
S
T
L
R
H
N
H
P
N
H
I
L
V
C
D
M
K
T
T
D
G
G
A
I
L
S
R
M
A
F
E
A
G
A
D
W
I
T
V
S
A
A
A
H
I
A
T
I
A
A
C
K
K
V
A
D
E
---
L
---
N
G
E
I
Q
I
E
I
Y
G
N
W
T
M
Q
D
A
K
A
W
V
D
L
G
I
T
Q
A
I
Y
H
R
S
R
D
A
E
L
A
G
I
G
W
T
T
D
D
L
D
K
M
R
Q
L
S
A
L
G
I
E
L
S
I
T
G
G
I
V
P
E
D
I
Y
L
F
E
G
I
K
T
K
T
--
F
I
A
G
R
A
L
A
G
A
E
-
G
Q
Q
T
A
A
A
L
R
E
Q
I
D
R
F
W
P
6
PsiBlast_PDB
74.78
48%
-127
- C4 -
-
1Q6L
2
ULAD_ECOLI
A:
[3-215]
---------------------------
L
P
M
L
Q
V
A
L
D
N
Q
T
M
D
S
A
Y
E
T
T
R
L
I
A
E
E
V
D
I
I
E
V
G
T
I
L
C
V
G
E
G
V
R
A
V
R
D
L
K
A
L
Y
P
H
K
I
V
L
A
D
A
K
I
A
D
A
G
K
I
L
S
R
M
C
F
E
A
N
A
D
W
V
T
V
I
C
C
A
D
I
N
T
A
K
G
A
L
D
V
A
K
E
F
N
G
D
------
V
Q
I
E
L
T
G
Y
W
T
W
E
Q
A
Q
Q
W
R
D
A
G
I
G
Q
V
V
Y
H
R
S
R
D
A
Q
A
A
G
V
A
W
G
E
A
D
I
T
A
I
K
R
L
S
D
M
G
F
K
V
T
V
T
G
G
L
A
L
E
D
L
P
L
F
K
G
I
P
I
H
V
--
F
I
A
G
R
S
I
R
D
A
A
S
P
V
E
A
A
R
Q
F
K
R
S
I
A
E
L
W
-
17
PsiBlast_PDB
74.45
47%
-132
- C4 -
-
1XBZ
2
ULAD_ECOLI
A:
[3-215]
---------------------------
L
P
M
L
Q
V
A
L
D
N
Q
T
M
D
S
A
Y
E
T
T
R
L
I
A
E
E
V
D
I
I
E
V
G
T
I
L
C
V
G
E
G
V
R
A
V
R
D
L
K
A
L
Y
P
H
K
I
V
L
A
D
A
K
I
A
D
A
G
K
I
L
S
R
M
C
F
E
A
N
A
D
W
V
T
V
I
C
C
A
D
I
N
T
A
K
G
A
L
D
V
A
K
E
F
N
G
D
------
V
Q
I
D
L
T
G
Y
W
T
W
E
Q
A
Q
Q
W
R
D
A
G
I
G
Q
V
V
Y
H
R
S
V
D
A
Q
---
V
A
W
G
E
A
D
I
T
A
I
K
R
L
S
D
M
G
F
K
V
T
V
A
G
G
L
A
L
E
D
L
P
L
F
K
G
I
P
I
H
V
--
F
I
A
G
R
S
I
R
D
A
A
S
P
V
E
A
A
R
Q
F
K
R
S
I
A
E
L
W
-