@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : spr1854: (2018-01-21 )
MTKTIAINAGSSSLKWQLYLMPEEKVLAKGLIERIGLKDSISTVKFDGRSEQQILDIENHIQAVKILLDDLIRFDIIKAYDEITGVGHRVVAGGEYFKESTVVEGDVLEKVEELSLLAPLHNPANAAGVRAFKELLPDITSVVVFDTSFHTSMPEKAYRYPLPTKYYTENKVRKYGAHGTSHQFVAGEAAKLLGRPLEDLKLITCHIGNGGSITAVKAGKSVDTSMGFTPLGGIMMGTRTGDIDPAIIPYLMQYTEDFNTPEDISRVLNRESGLLGVSANSSDMRDIEAAVAEGNHEASLAYEMYVDRIQKHIGQYLAVLNGADAIVFTAGVGENAESFRRDVISGISWFGCDVDDEKNVFGVTGDISTEAAKIRVLVIPTDEELVIARDVERLKK
Atome Classification :
(32 SA)
.........10........20........-30........40....-....50.--..-.-....60..----......70.--...--..--.--.80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280........290.......300.......310.......320.......330.......340.......350.......---360--....--.----...370.......380.......390....-
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
M
T
K
T
I
A
INAGSS
S
L
K
W
Q
L
Y
L
M
P
E
E
K
V
L
A
K
-
G
L
I
E
RIGLKDSI
S
T
V
K
-FDGRSE
Q
--
Q
I
-
L
-
D
I
E
N
H
I
Q
A
----
V
K
I
L
L
D
D
L
I
--
R
F
D
--
I
I
--
K
--
A
Y
D
E
I
TGVG
H
R
V
VAGGEYFKESTVV
E
G
D
V
L
E
K
V
E
E
L
S
L
LAPLHNPA
N
A
A
G
V
R
A
F
K
E
L
L
P
D
I
T
S
V
V
V
FDTSFHTSMPEKAYRYPLPTKYY
T
E
N
K
V
R
K
YGAHGTSHQ
F
V
A
G
E
A
A
K
L
LGR
P
L
E
D
L
K
L
I
T
C
H
IGNGG
S
I
T
A
V
KAGKSVDTSMGFTPLG
G
I
M
MGTRTGDI
D
P
A
I
I
P
Y
L
M
Q
Y
T
EDFN
T
P
E
D
I
S
R
V
L
NRES
G
L
L
G
V
SAN-S
S
D
M
R
D
I
E
A
A
V
AEGNH
E
A
S
L
A
Y
E
M
Y
V
D
R
I
Q
K
H
I
G
Q
Y
L
A
V
LNGA
D
A
I
V
F
TAGVGE
N
A
E
S
F
R
R
D
V
I
SGI
S
W
FGCDVDDEK
N
---
V
F
---
G
VTG--D----ISTE
A
A
K
I
R
V
L
V
IPTDE
E
L
V
I
A
R
D
V
E
R
LKK-
57
Fugue
82.71
51%
-10
- C7 -
-
1G99
1
ACKA_METTE
A:
[1-398]
-
M
K
V
L
V
I
N
A
G
S
S
S
L
K
Y
Q
L
I
D
M
T
N
E
S
A
L
A
V
-
G
L
C
E
R
I
G
I
D
N
S
I
I
T
Q
K
K
F
D
G
K
K
L
E
--
K
L
-
T
-
D
L
P
T
H
K
D
A
----
L
E
E
V
V
K
A
L
T
--
D
D
E
FG
V
I
--
K
--
D
M
G
E
I
N
A
V
G
H
R
V
V
H
G
G
E
K
F
T
T
S
A
L
Y
D
E
G
V
E
K
A
I
K
D
C
F
E
L
A
P
L
H
N
P
P
N
M
M
G
I
S
A
C
A
E
I
M
P
G
T
P
M
V
I
V
F
D
T
A
F
H
Q
T
M
P
P
Y
A
Y
M
Y
A
L
P
Y
D
L
Y
E
K
H
G
V
R
K
Y
G
F
H
G
T
S
H
K
Y
V
A
E
R
A
A
L
M
L
G
K
P
A
E
E
T
K
I
I
T
C
H
L
G
N
G
S
S
I
T
A
V
E
G
G
K
S
V
E
T
S
M
G
F
T
P
L
E
G
L
A
M
G
T
R
C
G
S
I
D
P
A
I
V
P
F
L
M
E
K
E
G
--
L
T
T
R
E
I
D
T
L
M
N
K
K
S
G
V
L
G
V
S
G
L
-
S
N
D
F
R
D
L
D
E
A
A
S
K
G
N
R
K
A
E
L
A
L
E
I
F
A
Y
K
V
K
K
F
I
G
E
Y
S
A
V
L
N
G
A
D
A
V
V
F
T
A
G
I
G
E
N
S
A
S
I
R
K
R
I
L
T
G
L
D
G
I
G
I
K
I
D
D
E
K
N
K
--
I
R
---
G
Q
E
I
--
D
----
I
S
T
P
D
A
K
V
R
V
F
V
I
P
T
N
E
E
L
A
I
A
R
E
T
K
E
I
V
E
T
35
PsiBlast_CBE
82.39
39%
-107
- C7 -
-
4FWL
1
TDCD_SALTY
A:
[21-405]
----
L
V
I
N
C
G
S
S
S
I
K
F
S
V
L
D
V
A
T
C
D
V
L
M
A
-
G
I
A
D
G
M
N
T
E
N
A
F
L
S
I
N
-
G
D
---
K
P
--
I
N
-----
S
N
Y
E
D
A
----
L
K
A
I
A
F
E
L
E
--
K
R
D
--
L
T
-------
D
S
V
A
L
I
G
H
R
I
A
H
G
G
E
L
F
T
Q
S
V
I
I
T
D
E
I
I
D
N
I
R
R
V
S
P
L
A
P
L
H
N
Y
A
N
L
S
G
I
D
A
A
R
H
L
F
P
A
V
R
Q
V
A
V
F
D
T
S
F
H
Q
T
L
A
P
E
A
Y
L
Y
G
L
P
W
E
Y
F
S
S
L
G
V
R
R
Y
G
F
H
G
T
S
H
R
Y
V
S
R
R
A
Y
E
L
L
D
L
D
E
K
D
S
G
L
I
V
A
H
L
G
N
G
A
S
I
C
A
V
R
N
G
Q
S
V
D
T
S
M
G
M
T
P
L
E
G
L
M
M
G
T
R
S
G
D
V
D
F
G
A
M
A
W
I
A
K
--
E
T
G
Q
T
L
S
D
L
E
R
V
V
N
K
E
S
G
L
L
G
I
S
G
L
-
S
S
D
L
R
V
L
E
K
A
W
H
E
G
H
E
R
A
R
L
A
I
K
T
F
V
H
R
I
A
R
H
I
A
G
H
A
A
S
L
H
R
L
D
G
I
I
F
T
G
G
I
G
E
N
S
V
L
I
R
Q
L
V
I
E
H
L
G
V
L
G
L
T
L
D
V
E
M
N
---
K
Q
---
P
N
S
H
--
G
ERI-
I
S
A
N
P
S
Q
V
I
C
A
V
I
P
T
N
E
E
K
M
I
A
L
D
A
I
H
L
---
32
PsiBlast_CBE
82.01
39%
-107
- C7 -
-
4FWP
3
TDCD_SALTY
A:
[21-405]
----
L
V
I
N
C
G
S
S
S
I
K
F
S
V
L
D
V
A
T
C
D
V
L
M
A
-
G
I
A
D
G
M
N
T
E
N
A
F
L
S
I
N
-
G
D
---
K
P
--
I
N
-
L
-
A
H
S
N
Y
E
D
A
----
L
K
A
I
A
F
E
L
E
--
K
R
D
--
L
T
-------
D
S
V
A
L
I
G
H
R
I
A
H
G
G
E
L
F
T
Q
S
V
I
I
T
D
E
I
I
D
N
I
R
R
V
S
P
L
A
P
L
H
N
Y
A
N
L
S
G
I
D
A
A
R
H
L
F
P
A
V
R
Q
V
A
V
F
D
T
S
F
H
Q
T
L
A
P
E
A
Y
L
Y
G
L
P
W
E
Y
F
S
S
L
G
V
R
R
Y
G
F
H
G
T
S
H
R
Y
V
S
R
R
A
Y
E
L
L
D
L
D
E
K
D
S
G
L
I
V
A
H
L
G
N
G
A
S
I
C
A
V
R
N
G
Q
S
V
D
T
S
M
G
M
T
P
L
E
G
L
M
M
G
T
R
S
G
D
V
D
F
G
A
M
A
W
I
A
K
--
E
T
G
Q
T
L
S
D
L
E
R
V
V
N
K
E
S
G
L
L
G
I
S
G
L
-
S
S
D
L
R
V
L
E
K
A
W
H
E
G
H
E
R
A
R
L
A
I
K
T
F
V
H
R
I
A
R
H
I
A
G
H
A
A
S
L
H
R
L
D
G
I
I
F
T
G
G
I
G
E
N
S
V
L
I
R
Q
L
V
I
E
H
L
G
V
L
G
L
T
L
D
V
E
M
N
---
K
Q
---
P
N
S
H
--
G
ERI-
I
S
A
N
P
S
Q
V
I
C
A
V
I
P
T
N
E
E
K
M
I
A
L
D
A
I
H
L
---
4
PsiBlast_PDB
81.95
50%
-4
- C7 -
-
2IIR
-
ACKA_THEMA
A:
[2-397]
--
R
V
L
V
I
N
S
G
S
S
S
I
K
Y
Q
L
I
E
M
E
G
E
K
V
L
C
K
-
G
I
A
E
R
I
G
I
E
G
S
R
L
V
H
R
-
V
G
D
E
K
H
V
--
I
E
-
R
-
E
L
P
D
H
E
E
A
----
L
K
L
I
L
N
T
L
V
DE
K
L
G
--
V
I
--
K
--
D
L
K
E
I
D
A
V
G
H
R
V
V
H
G
G
E
R
F
K
E
S
V
L
V
D
E
E
V
L
K
A
I
E
E
V
S
P
L
A
P
L
H
N
P
A
N
L
M
G
I
K
A
A
M
K
L
L
P
G
V
P
N
V
A
V
F
D
T
A
F
H
Q
T
I
P
Q
K
A
Y
L
Y
A
I
P
Y
E
Y
Y
E
K
Y
K
I
R
R
Y
G
F
H
G
T
S
H
R
Y
V
S
K
R
A
A
E
I
L
G
K
K
L
E
E
L
K
I
I
T
C
H
I
G
N
G
A
S
V
A
A
V
K
Y
G
K
C
V
D
T
S
M
G
F
T
P
L
E
G
L
V
M
G
T
R
S
G
D
L
D
P
A
-
I
P
F
F
I
M
E
K
E
G
I
-
S
P
Q
E
M
Y
D
I
L
N
K
K
S
G
V
Y
G
L
S
K
G
F
S
S
D
M
R
D
I
E
E
A
A
L
K
G
D
E
W
C
K
L
V
L
E
I
Y
D
Y
R
I
A
K
Y
I
G
A
Y
A
A
A
M
N
G
V
D
A
I
V
F
T
A
G
V
G
E
N
S
P
I
T
R
E
D
V
C
S
Y
L
E
F
L
G
V
K
L
D
K
Q
K
N
E
E
T
I
R
---
G
K
E
G
--
I
----
I
S
T
P
D
S
R
V
K
V
L
V
V
P
T
N
E
E
L
M
I
A
R
D
T
K
E
I
---
18
PsiBlast_PDB
81.89
39%
-107
- C7 -
-
4FWK
2
TDCD_SALTY
A:
[21-405]
----
L
V
I
N
C
G
S
S
S
I
K
F
S
V
L
D
V
A
T
C
D
V
L
M
A
-
G
I
A
D
G
M
N
T
E
N
A
F
L
S
I
N
-
G
D
---
K
P
--
I
N
-
L
-
A
H
S
N
Y
E
D
A
----
L
K
A
I
A
F
E
L
E
--
K
R
D
--
L
T
-------
D
S
V
A
L
I
G
H
R
I
A
H
G
G
E
L
F
T
Q
S
V
I
I
T
D
E
I
I
D
N
I
R
R
V
S
P
L
A
P
L
H
N
Y
A
N
L
S
G
I
D
A
A
R
H
L
F
P
A
V
R
Q
V
A
V
F
D
T
S
F
H
Q
T
L
A
P
E
A
Y
L
Y
G
L
P
W
E
Y
F
S
S
L
G
V
R
R
Y
G
F
H
G
T
S
H
R
Y
V
S
R
R
A
Y
E
L
L
D
L
D
E
K
D
S
G
L
I
V
A
H
L
G
N
G
A
S
I
C
A
V
R
N
G
Q
S
V
D
T
S
M
G
M
T
P
L
E
G
L
M
M
G
T
R
S
G
D
V
D
F
G
A
M
A
W
I
A
K
--
E
T
G
Q
T
L
S
D
L
E
R
V
V
N
K
E
S
G
L
L
G
I
S
G
L
-
S
S
D
L
R
V
L
E
K
A
W
H
E
G
H
E
R
A
R
L
A
I
K
T
F
V
H
R
I
A
R
H
I
A
G
H
A
A
S
L
H
R
L
D
G
I
I
F
T
G
G
I
G
E
N
S
V
L
I
R
Q
L
V
I
E
H
L
G
V
L
G
L
T
L
D
V
E
M
N
---
K
Q
---
P
N
S
H
--
G
ERI-
I
S
A
N
P
S
Q
V
I
C
A
V
I
P
T
N
E
E
K
M
I
A
L
D
A
I
H
L
---
14
PsiBlast_PDB
81.78
39%
-106
- C7 -
-
1X3N
2
TDCD_SALTY
A:
[21-405]
----
L
V
I
N
C
G
S
S
S
I
K
F
S
V
L
D
V
A
T
C
D
V
L
M
A
-
G
I
A
D
G
M
N
T
E
N
A
F
L
S
I
N
-
G
D
---
K
P
--
I
N
-
L
-
A
H
S
N
Y
E
D
A
----
L
K
A
I
A
F
E
L
E
--
K
R
D
--
L
T
-------
D
S
V
A
L
I
G
H
R
I
A
H
G
G
E
L
F
T
Q
S
V
I
I
T
D
E
I
I
D
N
I
R
R
V
S
P
L
A
P
L
H
N
Y
A
N
L
S
G
I
D
A
A
R
H
L
F
P
A
V
R
Q
V
A
V
F
D
T
S
F
H
Q
T
L
A
P
E
A
Y
L
Y
G
L
P
W
E
Y
F
S
S
L
G
V
R
R
Y
G
F
H
G
T
S
H
R
Y
V
S
R
R
A
Y
E
L
L
D
L
D
E
K
D
S
G
L
I
V
A
H
L
G
N
G
A
S
I
C
A
V
R
N
G
Q
S
V
D
T
S
M
G
M
T
P
L
E
G
L
M
M
G
T
R
S
G
D
V
D
F
G
A
M
A
W
I
A
K
--
E
T
G
Q
T
L
S
D
L
E
R
V
V
N
K
E
S
G
L
L
G
I
S
G
L
-
S
S
D
L
R
V
L
E
K
A
W
H
E
G
H
E
R
A
R
L
A
I
K
T
F
V
H
R
I
A
R
H
I
A
G
H
A
A
S
L
H
R
L
D
G
I
I
F
T
G
G
I
G
E
N
S
V
L
I
R
Q
L
V
I
E
H
L
G
V
L
G
L
T
L
D
V
E
M
N
---
K
Q
---
P
N
S
H
--
G
ERI-
I
S
A
N
P
S
Q
V
I
C
A
V
I
P
T
N
E
E
K
M
I
A
L
D
A
I
H
L
---
12
PsiBlast_PDB
81.75
39%
-102
- C7 -
-
4XH4
3
TDCD_SALTY
A:
[22-406]
----
L
V
I
N
C
G
S
S
S
I
K
F
S
V
L
D
V
A
T
C
D
V
L
M
A
-
G
I
A
D
G
M
N
T
E
N
A
F
L
S
I
N
-
G
D
---
K
P
--
I
N
-
L
-
A
H
S
N
Y
E
D
A
----
L
K
A
I
A
F
E
L
E
--
K
R
D
--
L
T
-------
D
S
V
A
L
I
G
H
R
I
V
H
G
G
E
L
F
T
Q
S
V
I
I
T
D
E
I
I
D
N
I
R
R
V
S
P
L
A
P
L
H
N
Y
A
N
L
S
G
I
D
A
A
R
H
L
F
P
A
V
R
Q
V
A
V
F
D
T
S
F
H
Q
T
L
A
P
E
A
Y
L
Y
G
L
P
W
E
Y
F
S
S
L
G
V
R
R
Y
G
F
H
G
T
S
H
R
Y
V
S
R
R
A
Y
E
L
L
D
L
D
E
K
D
S
G
L
I
V
A
H
L
G
N
G
A
S
I
C
A
V
R
N
G
Q
S
V
D
T
S
M
G
M
T
P
L
E
G
L
M
M
G
T
R
S
G
D
V
D
F
G
A
M
A
W
I
A
K
--
E
T
G
Q
T
L
S
D
L
E
R
V
V
N
K
E
S
G
L
L
G
I
S
G
L
-
S
S
D
L
R
V
L
E
K
A
W
H
E
G
H
E
R
A
R
L
A
I
K
T
F
V
H
R
I
A
R
H
I
A
G
H
A
A
S
L
H
R
L
D
G
I
I
F
T
G
G
I
G
E
N
S
V
L
I
R
Q
L
V
I
E
H
L
G
V
L
G
L
T
L
D
V
E
M
N
---
K
Q
---
P
N
S
H
--
G
ERI-
I
S
A
N
P
S
Q
V
I
C
A
V
I
P
T
N
E
E
K
M
I
A
L
D
A
I
H
L
---
36
PsiBlast_CBE
81.57
39%
-104
- C7 -
-
4XH5
3
TDCD_SALTY
A:
[22-406]
----
L
V
I
N
C
G
S
S
S
I
K
F
S
V
L
D
V
A
T
C
D
V
L
M
A
-
G
I
A
D
G
M
--
E
N
A
F
L
S
I
N
--
D
---
K
P
--
I
N
-
L
-
A
H
S
N
Y
E
D
A
----
L
K
A
I
A
F
E
L
E
--
K
R
D
--
L
T
-------
D
S
V
A
L
I
G
H
R
I
G
H
G
G
E
L
F
T
Q
S
V
I
I
T
D
E
I
I
D
N
I
R
R
V
S
P
L
A
P
L
H
N
Y
A
N
L
S
G
I
D
A
A
R
H
L
F
P
A
V
R
Q
V
A
V
F
D
T
S
F
H
Q
T
L
A
P
E
A
Y
L
Y
G
L
P
W
E
Y
F
S
S
L
G
V
R
R
Y
G
F
H
G
T
S
H
R
Y
V
S
R
R
A
Y
E
L
L
D
L
D
E
K
D
S
G
L
I
V
A
H
L
G
N
G
A
S
I
C
A
V
R
N
G
Q
S
V
D
T
S
M
G
M
T
P
L
E
G
L
M
M
G
T
R
S
G
D
V
D
F
G
A
M
A
W
I
A
K
--
E
T
G
Q
T
L
S
D
L
E
R
V
V
N
K
E
S
G
L
L
G
I
S
G
L
-
S
S
D
L
R
V
L
E
K
A
W
H
E
G
H
E
R
A
R
L
A
I
K
T
F
V
H
R
I
A
R
H
I
A
G
H
A
A
S
L
H
R
L
D
G
I
I
F
T
G
G
I
G
E
N
S
V
L
I
R
Q
L
V
I
E
H
L
G
V
L
G
L
T
L
D
V
E
M
N
---
K
Q
---
P
N
S
H
--
G
ERI-
I
S
A
N
P
S
Q
V
I
C
A
V
I
P
T
N
E
E
K
M
I
A
L
D
A
I
H
L
---
16
PsiBlast_PDB
81.53
39%
-106
- C7 -
-
2E1Z
2
TDCD_SALTY
A:
[21-405]
----
L
V
I
N
C
G
S
S
S
I
K
F
S
V
L
D
V
A
T
C
D
V
L
M
A
-
G
I
A
D
G
M
N
T
E
N
A
F
L
S
I
N
-
G
D
---
K
P
--
I
N
-
L
-
A
H
S
N
Y
E
D
A
----
L
K
A
I
A
F
E
L
E
--
K
R
D
--
L
T
-------
D
S
V
A
L
I
G
H
R
I
A
H
G
G
E
L
F
T
Q
S
V
I
I
T
D
E
I
I
D
N
I
R
R
V
S
P
L
A
P
L
H
N
Y
A
N
L
S
G
I
D
A
A
R
H
L
F
P
A
V
R
Q
V
A
V
F
D
T
S
F
H
Q
T
L
A
P
E
A
Y
L
Y
G
L
P
W
E
Y
F
S
S
L
G
V
R
R
Y
G
F
H
G
T
S
H
R
Y
V
S
R
R
A
Y
E
L
L
D
L
D
E
K
D
S
G
L
I
V
A
H
L
G
N
G
A
S
I
C
A
V
R
N
G
Q
S
V
D
T
S
M
G
M
T
P
L
E
G
L
M
M
G
T
R
S
G
D
V
D
F
G
A
M
A
W
I
A
K
--
E
T
G
Q
T
L
S
D
L
E
R
V
V
N
K
E
S
G
L
L
G
I
S
G
L
-
S
S
D
L
R
V
L
E
K
A
W
H
E
G
H
E
R
A
R
L
A
I
K
T
F
V
H
R
I
A
R
H
I
A
G
H
A
A
S
L
H
R
L
D
G
I
I
F
T
G
G
I
G
E
N
S
V
L
I
R
Q
L
V
I
E
H
L
G
V
L
G
L
T
L
D
V
E
M
N
---
K
Q
---
P
N
S
H
--
G
ERI-
I
S
A
N
P
S
Q
V
I
C
A
V
I
P
T
N
E
E
K
M
I
A
L
D
A
I
H
L
---
34
PsiBlast_CBE
81.29
39%
-106
- C7 -
-
4FWM
4
TDCD_SALTY
A:
[21-405]
----
L
V
I
N
C
G
S
S
S
I
K
F
S
V
L
D
V
A
T
C
D
V
L
M
A
-
G
I
A
D
G
M
N
T
E
N
A
F
L
S
I
N
-
G
D
---
K
P
--
I
N
-
L
-
A
H
S
N
Y
E
D
A
----
L
K
A
I
A
F
E
L
E
--
K
R
D
--
L
T
-------
D
S
V
A
L
I
G
H
R
I
A
H
G
G
E
L
F
T
Q
S
V
I
I
T
D
E
I
I
D
N
I
R
R
V
S
P
L
A
P
L
H
N
Y
A
N
L
S
G
I
D
A
A
R
H
L
F
P
A
V
R
Q
V
A
V
F
D
T
S
F
H
Q
T
L
A
P
E
A
Y
L
Y
G
L
P
W
E
Y
F
S
S
L
G
V
R
R
Y
G
F
H
G
T
S
H
R
Y
V
S
R
R
A
Y
E
L
L
D
L
D
E
K
D
S
G
L
I
V
A
H
L
G
N
G
A
S
I
C
A
V
R
N
G
Q
S
V
D
T
S
M
G
M
T
P
L
E
G
L
M
M
G
T
R
S
G
D
V
D
F
G
A
M
A
W
I
A
K
--
E
T
G
Q
T
L
S
D
L
E
R
V
V
N
K
E
S
G
L
L
G
I
S
G
L
-
S
S
D
L
R
V
L
E
K
A
W
H
E
G
H
E
R
A
R
L
A
I
K
T
F
V
H
R
I
A
R
H
I
A
G
H
A
A
S
L
H
R
L
D
G
I
I
F
T
G
G
I
G
E
N
S
V
L
I
R
Q
L
V
I
E
H
L
G
V
L
G
L
T
L
D
V
E
M
N
---
K
Q
---
P
N
S
H
--
G
ERI-
I
S
A
N
P
S
Q
V
I
C
A
V
I
P
T
N
E
E
K
M
I
A
L
D
A
I
H
L
---
7
PsiBlast_PDB
81.27
40%
-94
- C7 -
-
4IJN
3
ACKA_MYCS2
A:
[22-392]
M
V
T
V
L
V
V
N
S
G
S
S
S
L
K
Y
A
V
V
R
P
A
S
G
E
F
L
A
D
-
G
I
I
E
E
I
G
S
G
A
----------------------
V
P
D
H
D
A
A
----
L
R
A
A
F
D
E
L
A
--
A
A
G
--
L
H
--
L
--
E
D
L
D
L
K
A
V
G
H
R
M
V
H
G
G
K
T
F
Y
K
P
S
V
V
D
D
E
L
I
A
K
A
R
E
L
S
P
L
A
P
L
H
N
P
P
A
I
K
G
I
E
V
A
R
K
L
L
P
D
L
P
H
I
A
V
F
D
T
A
F
F
H
D
L
P
A
P
A
S
T
Y
A
I
D
R
E
L
A
E
T
W
H
I
K
R
Y
G
F
H
G
T
S
H
E
Y
V
S
Q
Q
A
A
I
F
L
D
R
P
L
E
S
L
N
Q
I
V
L
H
L
G
N
G
A
S
A
S
A
V
A
G
G
K
A
V
D
T
S
M
G
L
T
P
M
E
G
L
V
M
G
T
R
S
G
D
I
D
P
G
V
I
M
Y
L
W
R
-
T
A
G
M
S
V
-
D
D
I
E
S
M
L
N
R
R
S
G
V
L
G
L
-
G
G
-
A
S
D
F
R
K
L
R
E
L
I
E
S
G
D
E
H
A
K
L
A
Y
D
V
Y
I
H
R
L
R
K
Y
I
G
A
Y
M
A
V
L
G
R
T
D
V
I
S
F
T
A
G
V
G
E
N
V
P
P
V
R
R
D
A
L
A
G
L
G
G
L
G
I
E
I
D
D
A
L
N
--------
S
A
K
S
--
D
EPRL
I
S
T
P
D
S
R
V
T
V
L
V
V
P
T
N
E
E
L
A
I
A
R
--------
17
PsiBlast_PDB
81.04
39%
-104
- C7 -
-
2E20
2
TDCD_SALTY
A:
[21-405]
----
L
V
I
N
C
G
S
S
S
I
K
F
S
V
L
D
V
A
T
C
D
V
L
M
A
-
G
I
A
D
G
M
N
T
E
N
A
F
L
S
I
N
-
G
D
---
K
P
--
I
N
-
L
-
A
H
S
N
Y
E
D
A
----
L
K
A
I
A
F
E
L
E
--
K
R
D
--
L
T
-------
D
S
V
A
L
I
G
H
R
I
A
H
G
G
E
L
F
T
Q
S
V
I
I
T
D
E
I
I
D
N
I
R
R
V
S
P
L
A
P
L
H
N
Y
A
N
L
S
G
I
D
A
A
R
H
L
F
P
A
V
R
Q
V
A
V
F
D
T
S
F
H
Q
T
L
A
P
E
A
Y
L
Y
G
L
P
W
E
Y
F
S
S
L
G
V
R
R
Y
G
F
H
G
T
S
H
R
Y
V
S
R
R
A
Y
E
L
L
D
L
D
E
K
D
S
G
L
I
V
A
H
L
G
N
G
A
S
I
C
A
V
R
N
G
Q
S
V
D
T
S
M
G
M
T
P
L
E
G
L
M
M
G
T
R
S
G
D
V
D
F
G
A
M
A
W
I
A
K
--
E
T
G
Q
T
L
S
D
L
E
R
V
V
N
K
E
S
G
L
L
G
I
S
G
L
-
S
S
D
L
R
V
L
E
K
A
W
H
E
G
H
E
R
A
R
L
A
I
K
T
F
V
H
R
I
A
R
H
I
A
G
H
A
A
S
L
H
R
L
D
G
I
I
F
T
G
G
I
G
E
N
S
V
L
I
R
Q
L
V
I
E
H
L
G
V
L
G
L
T
L
D
V
E
M
N
---
K
Q
---
P
N
S
H
--
G
ERI-
I
S
A
N
P
S
Q
V
I
C
A
V
I
P
T
N
E
E
K
M
I
A
L
D
A
I
H
L
---
29
PsiBlast_CBE
80.70
39%
-103
- C7 -
-
4FWS
5
TDCD_SALTY
A:
[21-405]
----
L
V
I
N
C
G
S
S
S
I
K
F
S
V
L
D
V
A
T
C
D
V
L
M
A
-
G
I
A
D
G
M
N
T
E
N
A
F
L
S
I
N
-
G
D
---
K
P
--
I
N
-
L
-
A
H
S
N
Y
E
D
A
----
L
K
A
I
A
F
E
L
E
--
K
R
D
--
L
T
-------
D
S
V
A
L
I
G
H
R
I
A
H
G
G
E
L
F
T
Q
S
V
I
I
T
D
E
I
I
D
N
I
R
R
V
S
P
L
A
P
L
H
N
Y
A
N
L
S
G
I
D
A
A
R
H
L
F
P
A
V
R
Q
V
A
V
F
D
T
S
F
H
Q
T
L
A
P
E
A
Y
L
Y
G
L
P
W
E
Y
F
S
S
L
G
V
R
R
Y
G
F
H
G
T
S
H
R
Y
V
S
R
R
A
Y
E
L
L
D
L
D
E
K
D
S
G
L
I
V
A
H
L
G
N
G
A
S
I
C
A
V
R
N
G
Q
S
V
D
T
S
M
G
M
T
P
L
E
G
L
M
M
G
T
R
S
G
D
V
D
F
G
A
M
A
W
I
A
K
--
E
T
G
Q
T
L
S
D
L
E
R
V
V
N
K
E
S
G
L
L
G
I
S
G
L
-
S
S
D
L
R
V
L
E
K
A
W
H
E
G
H
E
R
A
R
L
A
I
K
T
F
V
H
R
I
A
R
H
I
A
G
H
A
A
S
L
H
R
L
D
G
I
I
F
T
G
G
I
G
E
N
S
V
L
I
R
Q
L
V
I
E
H
L
G
V
L
G
L
T
L
D
V
E
M
N
---
K
Q
---
P
N
S
H
--
G
ERI-
I
S
A
N
P
S
Q
V
I
C
A
V
I
P
T
N
E
E
K
M
I
A
L
D
A
I
H
L
---
27
PsiBlast_CBE
80.56
40%
-99
- C7 -
-
4IJN
2
ACKA_MYCS2
B:
[23-392]
-
V
T
V
L
V
V
N
S
G
S
S
S
L
K
Y
A
V
V
R
P
A
S
G
E
F
L
A
D
-
G
I
I
E
E
I
G
S
G
A
----------------------
V
P
D
H
D
A
A
----
L
R
A
A
F
D
E
L
A
--
A
A
G
--
L
H
--
L
--
E
D
L
D
L
K
A
V
G
H
R
M
V
H
G
G
K
T
F
Y
K
P
S
V
V
D
D
E
L
I
A
K
A
R
E
L
S
P
L
A
P
L
H
N
P
P
A
I
K
G
I
E
V
A
R
K
L
L
P
D
L
P
H
I
A
V
F
D
T
A
F
F
H
D
L
P
A
P
A
S
T
Y
A
I
D
R
E
L
A
E
T
W
H
I
K
R
Y
G
F
H
G
T
S
H
E
Y
V
S
Q
Q
A
A
I
F
L
D
R
P
L
E
S
L
N
Q
I
V
L
H
L
G
N
G
A
S
A
S
A
V
A
G
G
K
A
V
D
T
S
M
G
L
T
P
M
E
G
L
V
M
G
T
R
S
G
D
I
D
P
G
V
I
M
Y
L
W
R
-
T
A
G
M
S
V
-
D
D
I
E
S
M
L
N
R
R
S
G
V
L
G
L
-
G
G
-
A
S
D
F
R
K
L
R
E
L
I
E
S
G
D
E
H
A
K
L
A
Y
D
V
Y
I
H
R
L
R
K
Y
I
G
A
Y
M
A
V
L
G
R
T
D
V
I
S
F
T
A
G
V
G
E
N
V
P
P
V
R
R
D
A
L
A
G
L
G
G
L
G
I
E
I
D
D
A
L
N
--------
S
A
K
S
--
D
EPRL
I
S
T
P
D
S
R
V
T
V
L
V
V
P
T
N
E
E
L
A
I
A
R
--------
20
PsiBlast_PDB
80.54
39%
-106
- C7 -
-
4FWO
4
TDCD_SALTY
A:
[21-405]
----
L
V
I
N
C
G
S
S
S
I
K
F
S
V
L
D
V
A
T
C
D
V
L
M
A
-
G
I
A
D
G
M
N
T
E
N
A
F
L
S
I
N
-
G
D
---
K
P
--
I
N
-
L
-
A
H
S
N
Y
E
D
A
----
L
K
A
I
A
F
E
L
E
--
K
R
D
--
L
T
-------
D
S
V
A
L
I
G
H
R
I
A
H
G
G
E
L
F
T
Q
S
V
I
I
T
D
E
I
I
D
N
I
R
R
V
S
P
L
A
P
L
H
N
Y
A
N
L
S
G
I
D
A
A
R
H
L
F
P
A
V
R
Q
V
A
V
F
D
T
S
F
H
Q
T
L
A
P
E
A
Y
L
Y
G
L
P
W
E
Y
F
S
S
L
G
V
R
R
Y
G
F
H
G
T
S
H
R
Y
V
S
R
R
A
Y
E
L
L
D
L
D
E
K
D
S
G
L
I
V
A
H
L
G
N
G
A
S
I
C
A
V
R
N
G
Q
S
V
D
T
S
M
G
M
T
P
L
E
G
L
M
M
G
T
R
S
G
D
V
D
F
G
A
M
A
W
I
A
K
--
E
T
G
Q
T
L
S
D
L
E
R
V
V
N
K
E
S
G
L
L
G
I
S
G
L
-
S
S
D
L
R
V
L
E
K
A
W
H
E
G
H
E
R
A
R
L
A
I
K
T
F
V
H
R
I
A
R
H
I
A
G
H
A
A
S
L
H
R
L
D
G
I
I
F
T
G
G
I
G
E
N
S
V
L
I
R
Q
L
V
I
E
H
L
G
V
L
G
L
T
L
D
V
E
M
N
---
K
Q
---
P
N
S
H
--
G
ERI-
I
S
A
N
P
S
Q
V
I
C
A
V
I
P
T
N
E
E
K
M
I
A
L
D
A
I
H
L
---
30
PsiBlast_CBE
80.47
39%
-102
- C7 -
-
4FWR
3
TDCD_SALTY
A:
[21-405]
----
L
V
I
N
C
G
S
S
S
I
K
F
S
V
L
D
V
A
T
C
D
V
L
M
A
-
G
I
A
D
G
M
N
T
E
N
A
F
L
S
I
N
-
G
D
---
K
P
--
I
N
-
L
-
A
H
S
N
Y
E
D
A
----
L
K
A
I
A
F
E
L
E
--
K
R
D
--
L
T
-------
D
S
V
A
L
I
G
H
R
I
A
H
G
G
E
L
F
T
Q
S
V
I
I
T
D
E
I
I
D
N
I
R
R
V
S
P
L
A
P
L
H
N
Y
A
N
L
S
G
I
D
A
A
R
H
L
F
P
A
V
R
Q
V
A
V
F
D
T
S
F
H
Q
T
L
A
P
E
A
Y
L
Y
G
L
P
W
E
Y
F
S
S
L
G
V
R
R
Y
G
F
H
G
T
S
H
R
Y
V
S
R
R
A
Y
E
L
L
D
L
D
E
K
D
S
G
L
I
V
A
H
L
G
N
G
A
S
I
C
A
V
R
N
G
Q
S
V
D
T
S
M
G
M
T
P
L
E
G
L
M
M
G
T
R
S
G
D
V
D
F
G
A
M
A
W
I
A
K
--
E
T
G
Q
T
L
S
D
L
E
R
V
V
N
K
E
S
G
L
L
G
I
S
G
L
-
S
S
D
L
R
V
L
E
K
A
W
H
E
G
H
E
R
A
R
L
A
I
K
T
F
V
H
R
I
A
R
H
I
A
G
H
A
A
S
L
H
R
L
D
G
I
I
F
T
G
G
I
G
E
N
S
V
L
I
R
Q
L
V
I
E
H
L
G
V
L
G
L
T
L
D
V
E
M
N
---
K
Q
---
P
N
S
H
--
G
ERI-
I
S
A
N
P
S
Q
V
I
C
A
V
I
P
T
N
E
E
K
M
I
A
L
D
A
I
H
L
---
13
PsiBlast_PDB
80.26
39%
-103
- C7 -
-
1X3M
1
TDCD_SALTY
A:
[21-405]
----
L
V
I
N
C
G
S
S
S
I
K
F
S
V
L
D
V
A
T
C
D
V
L
M
A
-
G
I
A
D
G
M
N
T
E
N
A
F
L
S
I
N
-
G
D
---
K
P
--
I
N
-
L
-
A
H
S
N
Y
E
D
A
----
L
K
A
I
A
F
E
L
E
--
K
R
D
--
L
T
-------
D
S
V
A
L
I
G
H
R
I
A
H
G
G
E
L
F
T
Q
S
V
I
I
T
D
E
I
I
D
N
I
R
R
V
S
P
L
A
P
L
H
N
Y
A
N
L
S
G
I
D
A
A
R
H
L
F
P
A
V
R
Q
V
A
V
F
D
T
S
F
H
Q
T
L
A
P
E
A
Y
L
Y
G
L
P
W
E
Y
F
S
S
L
G
V
R
R
Y
G
F
H
G
T
S
H
R
Y
V
S
R
R
A
Y
E
L
L
D
L
D
E
K
D
S
G
L
I
V
A
H
L
G
N
G
A
S
I
C
A
V
R
N
G
Q
S
V
D
T
S
M
G
M
T
P
L
E
G
L
M
M
G
T
R
S
G
D
V
D
F
G
A
M
A
W
I
A
K
--
E
T
G
Q
T
L
S
D
L
E
R
V
V
N
K
E
S
G
L
L
G
I
S
G
L
-
S
S
D
L
R
V
L
E
K
A
W
H
E
G
H
E
R
A
R
L
A
I
K
T
F
V
H
R
I
A
R
H
I
A
G
H
A
A
S
L
H
R
L
D
G
I
I
F
T
G
G
I
G
E
N
S
V
L
I
R
Q
L
V
I
E
H
L
G
V
L
G
L
T
L
D
V
E
M
N
---
K
Q
---
P
N
S
H
--
G
ERI-
I
S
A
N
P
S
Q
V
I
C
A
V
I
P
T
N
E
E
K
M
I
A
L
D
A
I
H
L
---
19
PsiBlast_PDB
80.23
39%
-100
- C7 -
-
4FWN
3
TDCD_SALTY
A:
[21-405]
----
L
V
I
N
C
G
S
S
S
I
K
F
S
V
L
D
V
A
T
C
D
V
L
M
A
-
G
I
A
D
G
M
N
T
E
N
A
F
L
S
I
N
-
G
D
---
K
P
--
I
N
-
L
-
A
H
S
N
Y
E
D
A
----
L
K
A
I
A
F
E
L
E
--
K
R
D
--
L
T
-------
D
S
V
A
L
I
G
H
R
I
A
H
G
G
E
L
F
T
Q
S
V
I
I
T
D
E
I
I
D
N
I
R
R
V
S
P
L
A
P
L
H
N
Y
A
N
L
S
G
I
D
A
A
R
H
L
F
P
A
V
R
Q
V
A
V
F
D
T
S
F
H
Q
T
L
A
P
E
A
Y
L
Y
G
L
P
W
E
Y
F
S
S
L
G
V
R
R
Y
G
F
H
G
T
S
H
R
Y
V
S
R
R
A
Y
E
L
L
D
L
D
E
K
D
S
G
L
I
V
A
H
L
G
N
G
A
S
I
C
A
V
R
N
G
Q
S
V
D
T
S
M
G
M
T
P
L
E
G
L
M
M
G
T
R
S
G
D
V
D
F
G
A
M
A
W
I
A
K
--
E
T
G
Q
T
L
S
D
L
E
R
V
V
N
K
E
S
G
L
L
G
I
S
G
L
-
S
S
D
L
R
V
L
E
K
A
W
H
E
G
H
E
R
A
R
L
A
I
K
T
F
V
H
R
I
A
R
H
I
A
G
H
A
A
S
L
H
R
L
D
G
I
I
F
T
G
G
I
G
E
N
S
V
L
I
R
Q
L
V
I
E
H
L
G
V
L
G
L
T
L
D
V
E
M
N
---
K
Q
---
P
N
S
H
--
G
ERI-
I
S
A
N
P
S
Q
V
I
C
A
V
I
P
T
N
E
E
K
M
I
A
L
D
A
I
H
L
---
33
PsiBlast_CBE
80.11
39%
-105
- C7 -
-
4XH1
4
TDCD_SALTY
A:
[22-406]
----
L
V
I
N
C
G
S
S
S
I
K
F
S
V
L
D
V
A
T
C
D
V
L
M
A
-
G
I
A
D
G
M
-
T
E
N
A
F
L
S
I
N
-
G
D
---
K
P
--
I
N
-
L
-
A
H
S
N
Y
E
D
A
----
L
K
A
I
A
F
E
L
E
--
K
R
D
--
L
T
-------
D
S
V
A
L
I
G
H
R
I
A
H
G
G
E
L
F
T
Q
S
V
I
I
T
D
E
I
I
D
N
I
R
R
V
S
P
L
A
P
L
H
N
Y
A
N
L
S
G
I
D
A
A
R
H
L
F
P
A
V
R
Q
V
A
V
F
D
T
S
F
H
Q
T
L
A
P
E
A
Y
L
Y
G
L
P
W
E
Y
F
S
S
L
G
V
R
R
Y
G
F
H
G
T
S
H
R
Y
V
S
R
R
A
Y
E
L
L
D
L
D
E
K
D
S
G
L
I
V
A
H
L
G
N
G
A
S
I
C
A
V
R
N
G
Q
S
V
D
T
S
M
G
M
T
P
L
E
G
L
M
M
G
T
R
S
G
D
V
D
F
G
A
M
A
W
I
A
K
--
E
T
G
Q
T
L
S
D
L
E
R
V
V
N
K
E
S
G
L
L
G
I
S
G
L
-
S
S
D
L
R
V
L
E
K
A
W
H
E
G
H
E
R
A
R
L
A
I
K
T
F
V
H
R
I
A
R
H
I
A
G
H
A
A
S
L
H
R
L
D
G
I
I
F
T
G
G
I
G
E
N
S
V
L
I
R
Q
L
V
I
E
H
L
G
V
L
G
L
T
L
D
V
E
M
N
---
K
Q
---
P
N
S
H
--
G
ERI-
I
S
A
N
P
S
Q
V
I
C
A
V
I
P
T
N
E
E
K
M
I
A
L
D
A
I
H
L
---
31
PsiBlast_CBE
79.57
39%
-104
- C7 -
-
4FWQ
3
TDCD_SALTY
A:
[21-405]
----
L
V
I
N
C
G
S
S
S
I
K
F
S
V
L
D
V
A
T
C
D
V
L
M
A
-
G
I
A
D
G
M
N
T
E
N
A
F
L
S
I
N
-
G
D
---
K
P
--
I
N
-
L
-
A
H
S
N
Y
E
D
A
----
L
K
A
I
A
F
E
L
E
--
K
R
D
--
L
T
-------
D
S
V
A
L
I
G
H
R
I
A
H
G
G
E
L
F
T
Q
S
V
I
I
T
D
E
I
I
D
N
I
R
R
V
S
P
L
A
P
L
H
N
Y
A
N
L
S
G
I
D
A
A
R
H
L
F
P
A
V
R
Q
V
A
V
F
D
T
S
F
H
Q
T
L
A
P
E
A
Y
L
Y
G
L
P
W
E
Y
F
S
S
L
G
V
R
R
Y
G
F
H
G
T
S
H
R
Y
V
S
R
R
A
Y
E
L
L
D
L
D
E
K
D
S
G
L
I
V
A
H
L
G
N
G
A
S
I
C
A
V
R
N
G
Q
S
V
D
T
S
M
G
M
T
P
L
E
G
L
M
M
G
T
R
S
G
D
V
D
F
G
A
M
A
W
I
A
K
--
E
T
G
Q
T
L
S
D
L
E
R
V
V
N
K
E
S
G
L
L
G
I
S
G
L
-
S
S
D
L
R
V
L
E
K
A
W
H
E
G
H
E
R
A
R
L
A
I
K
T
F
V
H
R
I
A
R
H
I
A
G
H
A
A
S
L
H
R
L
D
G
I
I
F
T
G
G
I
G
E
N
S
V
L
I
R
Q
L
V
I
E
H
L
G
V
L
G
L
T
L
D
V
E
M
N
---
K
Q
---
P
N
S
H
--
G
ERI-
I
S
A
N
P
S
Q
V
I
C
A
V
I
P
T
N
E
E
K
M
I
A
L
D
A
I
H
L
---
48
HHSearch
78.32
50%
36
- C7 -
-
1G99
1
ACKA_METTE
B:
[1-397]
-
M
K
V
L
V
I
N
A
G
S
S
S
L
K
Y
Q
L
I
D
M
T
N
E
S
A
L
A
V
-
G
L
C
E
R
I
G
I
D
N
S
I
--
I
T
-
Q
K
K
F
D
G
K
K-
L
E
K
L
T
D
L
P
T
H
K
D
A
----
L
E
E
V
V
K
A
L
T
--
D
D
E
--
F
G
VI
K
--
D
M
G
E
I
N
A
V
G
H
R
V
V
H
G
G
E
K
F
T
T
S
A
L
Y
D
E
G
V
E
K
A
I
K
D
C
F
E
L
A
P
L
H
N
P
P
N
M
M
G
I
S
A
C
A
E
I
M
P
G
T
P
M
V
I
V
F
D
T
A
F
H
Q
T
M
P
P
Y
A
Y
M
Y
A
L
P
Y
D
L
Y
E
K
H
G
V
R
K
Y
G
F
H
G
T
S
H
K
Y
V
A
E
R
A
A
L
M
L
G
K
P
A
E
E
T
K
I
I
T
C
H
L
G
N
G
S
S
I
T
A
V
E
G
G
K
S
V
E
T
S
M
G
F
T
P
L
E
G
L
A
M
G
T
R
C
G
S
I
D
P
A
I
V
P
F
L
M
E
K
-
E
G
L
-
T
T
R
E
I
D
T
L
M
N
K
K
S
G
V
L
G
V
S
G
L
-
S
N
D
F
R
D
L
D
E
A
A
S
K
G
N
R
K
A
E
L
A
L
E
I
F
A
Y
K
V
K
K
F
I
G
E
Y
S
A
V
L
N
G
A
D
A
V
V
F
T
A
G
I
G
E
N
S
A
S
I
R
K
R
I
L
T
G
L
D
G
I
G
I
K
I
D
D
E
K
N
---
K
I
R--
G
Q
E
I
--
D
----
I
S
T
P
D
A
K
V
R
V
F
V
I
P
T
N
E
E
L
A
I
A
R
E
T
K
E
I
V
E
-
21
PsiBlast_CBE
77.89
51%
34
- C7 -
-
1G99
1
ACKA_METTE
B:
[2-395]
--
K
V
L
V
I
N
A
G
S
S
S
L
K
Y
Q
L
I
D
M
T
N
E
S
A
L
A
V
-
G
L
C
E
R
I
G
I
D
N
S
I
I
T
Q
K
K
F
D
G
K
K
L
E
--
K
L
-
T
-
D
L
P
T
H
K
D
A
LEEV
V
K
A
L
T
D
D
----
E
F
G
--
V
I
--
K
--
D
M
G
E
I
N
A
V
G
H
R
V
V
H
G
G
E
K
F
T
T
S
A
L
Y
D
E
G
V
E
K
A
I
K
D
C
F
E
L
A
P
L
H
N
P
P
N
M
M
G
I
S
A
C
A
E
I
M
P
G
T
P
M
V
I
V
F
D
T
A
F
H
Q
T
M
P
P
Y
A
Y
M
Y
A
L
P
Y
D
L
Y
E
K
H
G
V
R
K
Y
G
F
H
G
T
S
H
K
Y
V
A
E
R
A
A
L
M
L
G
K
P
A
E
E
T
K
I
I
T
C
H
L
G
N
G
S
S
I
T
A
V
E
G
G
K
S
V
E
T
S
M
G
F
T
P
L
E
G
L
A
M
G
T
R
C
G
S
I
D
P
A
I
V
P
F
L
M
E
--
K
E
G
L
T
T
R
E
I
D
T
L
M
N
K
K
S
G
V
L
G
V
S
G
L
-
S
N
D
F
R
D
L
D
E
A
A
S
K
G
N
R
K
A
E
L
A
L
E
I
F
A
Y
K
V
K
K
F
I
G
E
Y
S
A
V
L
N
G
A
D
A
V
V
F
T
A
G
I
G
E
N
S
A
S
I
R
K
R
I
L
T
G
L
D
G
I
G
I
K
I
D
D
E
K
N
K--
I
R
---
G
Q
E
I
--
D
----
I
S
T
P
D
A
K
V
R
V
F
V
I
P
T
N
E
E
L
A
I
A
R
E
T
K
E
I
---
22
PsiBlast_CBE
77.13
51%
37
- C7 -
-
1TUY
3
ACKA_METTE
B:
[2-395]
--
K
V
L
V
I
N
A
G
S
S
S
L
K
Y
Q
L
I
D
M
T
N
E
S
A
L
A
V
-
G
L
C
E
R
I
G
I
D
N
S
I
I
T
Q
K
K
F
D
G
K
K
L
E
--
K
L
-
T
-
D
L
P
T
H
K
D
A
LEEV
V
K
A
L
T
D
D
----
E
F
G
--
V
I
--
K
--
D
M
G
E
I
N
A
V
G
H
R
V
V
H
G
G
E
K
F
T
T
S
A
L
Y
D
E
G
V
E
K
A
I
K
D
C
F
E
L
A
P
L
H
N
P
P
N
M
M
G
I
S
A
C
A
E
I
M
P
G
T
P
M
V
I
V
F
D
T
A
F
H
Q
T
M
P
P
Y
A
Y
M
Y
A
L
P
Y
D
L
Y
E
K
H
G
V
R
K
Y
G
F
H
G
T
S
H
K
Y
V
A
E
R
A
A
L
M
L
G
K
P
A
E
E
T
K
I
I
T
C
H
L
G
N
G
S
S
I
T
A
V
E
G
G
K
S
V
E
T
S
M
G
F
T
P
L
E
G
L
A
M
G
T
R
C
G
S
I
D
P
A
I
V
P
F
L
M
E
--
K
E
G
L
T
T
R
E
I
D
T
L
M
N
K
K
S
G
V
L
G
V
S
G
L
-
S
N
D
F
R
D
L
D
E
A
A
S
K
G
N
R
K
A
E
L
A
L
E
I
F
A
Y
K
V
K
K
F
I
G
E
Y
S
A
V
L
N
G
A
D
A
V
V
F
T
A
G
I
G
E
N
S
A
S
I
R
K
R
I
L
T
G
L
D
G
I
G
I
K
I
D
D
E
K
N
K--
I
R
---
G
Q
E
I
--
D
----
I
S
T
P
D
A
K
V
R
V
F
V
I
P
T
N
E
E
L
A
I
A
R
E
T
K
E
I
---
23
PsiBlast_CBE
76.35
51%
35
- C7 -
-
1TUU
2
ACKA_METTE
B:
[2-395]
--
K
V
L
V
I
N
A
G
S
S
S
L
K
Y
Q
L
I
D
M
T
N
E
S
A
L
A
V
-
G
L
C
E
R
I
G
I
D
N
S
I
I
T
Q
K
K
F
D
G
K
K
L
E
--
K
L
-
T
-
D
L
P
T
H
K
D
A
LEEV
V
K
A
L
T
D
D
----
E
F
G
--
V
I
--
K
--
D
M
G
E
I
N
A
V
G
H
R
V
V
H
G
G
E
K
F
T
T
S
A
L
Y
D
E
G
V
E
K
A
I
K
D
C
F
E
L
A
P
L
H
N
P
P
N
M
M
G
I
S
A
C
A
E
I
M
P
G
T
P
M
V
I
V
F
D
T
A
F
H
Q
T
M
P
P
Y
A
Y
M
Y
A
L
P
Y
D
L
Y
E
K
H
G
V
R
K
Y
G
F
H
G
T
S
H
K
Y
V
A
E
R
A
A
L
M
L
G
K
P
A
E
E
T
K
I
I
T
C
H
L
G
N
G
S
S
I
T
A
V
E
G
G
K
S
V
E
T
S
M
G
F
T
P
L
E
G
L
A
M
G
T
R
C
G
S
I
D
P
A
I
V
P
F
L
M
E
--
K
E
G
L
T
T
R
E
I
D
T
L
M
N
K
K
S
G
V
L
G
V
S
G
L
-
S
N
D
F
R
D
L
D
E
A
A
S
K
G
N
R
K
A
E
L
A
L
E
I
F
A
Y
K
V
K
K
F
I
G
E
Y
S
A
V
L
N
G
A
D
A
V
V
F
T
A
G
I
G
E
N
S
A
S
I
R
K
R
I
L
T
G
L
D
G
I
G
I
K
I
D
D
E
K
N
K--
I
R
---
G
Q
E
I
--
D
----
I
S
T
P
D
A
K
V
R
V
F
V
I
P
T
N
E
E
L
A
I
A
R
E
T
K
E
I
---
47
HHSearch
76.29
50%
34
- C7 -
-
1TUU
1
ACKA_METTE
A:
[1-397]
-
M
K
V
L
V
I
N
A
G
S
S
S
L
K
Y
Q
L
I
D
M
T
N
E
S
A
L
A
V
-
G
L
C
E
R
I
G
I
D
N
S
I
--
I
T
-
Q
K
K
F
D
G
K
K
L
E
K
-
L
T
D
L
P
T
H
K
D
A
----
L
E
E
V
V
K
A
L
T
--
D
D
E
--
F
G
VI
K
--
D
M
G
E
I
N
A
V
G
H
R
V
V
H
G
G
E
K
F
T
T
S
A
L
Y
D
E
G
V
E
K
A
I
K
D
C
F
E
L
A
P
L
H
N
P
P
N
M
M
G
I
S
A
C
A
E
I
M
P
G
T
P
M
V
I
V
F
D
T
A
F
H
Q
T
M
P
P
Y
A
Y
M
Y
A
L
P
Y
D
L
Y
E
K
H
G
V
R
K
Y
G
F
H
G
T
S
H
K
Y
V
A
E
R
A
A
L
M
L
G
K
P
A
E
E
T
K
I
I
T
C
H
L
G
N
G
S
S
I
T
A
V
E
G
G
K
S
V
E
T
S
M
G
F
T
P
L
E
G
L
A
M
G
T
R
C
G
S
I
D
P
A
I
V
P
F
L
M
E
K
-
E
G
L
-
T
T
R
E
I
D
T
L
M
N
K
K
S
G
V
L
G
V
S
G
L
-
S
N
D
F
R
D
L
D
E
A
A
S
K
G
N
R
K
A
E
L
A
L
E
I
F
A
Y
K
V
K
K
F
I
G
E
Y
S
A
V
L
N
G
A
D
A
V
V
F
T
A
G
I
G
E
N
S
A
S
I
R
K
R
I
L
T
G
L
D
G
I
G
I
K
I
D
D
E
K
N
---
K
I
R--
G
Q
E
I
--
D
----
I
S
T
P
D
A
K
V
R
V
F
V
I
P
T
N
E
E
L
A
I
A
R
E
T
K
E
I
V
E
-
43
HHSearch
76.27
40%
-33
- C7 -
-
4XH4
3
TDCD_SALTY
A:
[18-408]
F
P
V
V
L
V
I
N
C
G
S
S
S
I
K
F
S
V
L
D
V
A
T
C
D
V
L
M
A
-
G
I
A
D
G
M
N
T
E
N
A
F
--
L
S
-
I
N
G
--
D
K
--
P
I
-
N
L
A
H
S
N
Y
E
D
A
----
L
K
A
I
A
F
E
L
E
--
K
----
R
D
-----
L
T
D
S
V
A
L
I
G
H
R
I
V
H
G
G
E
L
F
T
Q
S
V
I
I
T
D
E
I
I
D
N
I
R
R
V
S
P
L
A
P
L
H
N
Y
A
N
L
S
G
I
D
A
A
R
H
L
F
P
A
V
R
Q
V
A
V
F
D
T
S
F
H
Q
T
L
A
P
E
A
Y
L
Y
G
L
P
W
E
Y
F
S
S
L
G
V
R
R
Y
G
F
H
G
T
S
H
R
Y
V
S
R
R
A
Y
E
L
L
D
L
D
E
K
D
S
G
L
I
V
A
H
L
G
N
G
A
S
I
C
A
V
R
N
G
Q
S
V
D
T
S
M
G
M
T
P
L
E
G
L
M
M
G
T
R
S
G
D
V
D
F
G
A
M
A
W
I
A
K
E
-
T
G
Q
-
T
L
S
D
L
E
R
V
V
N
K
E
S
G
L
L
G
I
S
G
L
-
S
S
D
L
R
V
L
E
K
A
W
H
E
G
H
E
R
A
R
L
A
I
K
T
F
V
H
R
I
A
R
H
I
A
G
H
A
A
S
L
H
R
L
D
G
I
I
F
T
G
G
I
G
E
N
S
V
L
I
R
Q
L
V
I
E
H
L
G
V
L
G
L
T
L
D
V
E
M
N
---
K
Q
PNS
H
G
E
R
--
I
----
I
S
A
N
P
S
Q
V
I
C
A
V
I
P
T
N
E
E
K
M
I
A
L
D
A
I
H
L
G
N
-
44
HHSearch
75.12
40%
-35
- C7 -
-
4FWM
4
TDCD_SALTY
A:
[17-406]
F
P
V
V
L
V
I
N
C
G
S
S
S
I
K
F
S
V
L
D
V
A
T
C
D
V
L
M
A
-
G
I
A
D
G
M
N
T
E
N
A
F
--
L
S
-
I
N
G
--
D
K
--
P
I
-
N
L
A
H
S
N
Y
E
D
A
----
L
K
A
I
A
F
E
L
E
--
K
----
R
D
-----
L
T
D
S
V
A
L
I
G
H
R
I
A
H
G
G
E
L
F
T
Q
S
V
I
I
T
D
E
I
I
D
N
I
R
R
V
S
P
L
A
P
L
H
N
Y
A
N
L
S
G
I
D
A
A
R
H
L
F
P
A
V
R
Q
V
A
V
F
D
T
S
F
H
Q
T
L
A
P
E
A
Y
L
Y
G
L
P
W
E
Y
F
S
S
L
G
V
R
R
Y
G
F
H
G
T
S
H
R
Y
V
S
R
R
A
Y
E
L
L
D
L
D
E
K
D
S
G
L
I
V
A
H
L
G
N
G
A
S
I
C
A
V
R
N
G
Q
S
V
D
T
S
M
G
M
T
P
L
E
G
L
M
M
G
T
R
S
G
D
V
D
F
G
A
M
A
W
I
A
K
E
-
T
G
Q
-
T
L
S
D
L
E
R
V
V
N
K
E
S
G
L
L
G
I
S
G
L
-
S
S
D
L
R
V
L
E
K
A
W
H
E
G
H
E
R
A
R
L
A
I
K
T
F
V
H
R
I
A
R
H
I
A
G
H
A
A
S
L
H
R
L
D
G
I
I
F
T
G
G
I
G
E
N
S
V
L
I
R
Q
L
V
I
E
H
L
G
V
L
G
L
T
L
D
V
E
M
N
---
K
Q
PNS
H
G
E
R
--
I
----
I
S
A
N
P
S
Q
V
I
C
A
V
I
P
T
N
E
E
K
M
I
A
L
D
A
I
H
L
G
--
45
HHSearch
74.88
43%
-24
* C7 *
-
3R9P
3
ACKA_MYCPA
A:
[12-390]
-
R
R
V
L
V
I
N
S
G
S
S
S
L
K
F
Q
L
V
D
P
E
F
G
-
V
A
A
S
T
G
I
V
E
R
I
G
E
E
S
S
--------------------
P
V
P
D
H
D
A
A
----
L
R
R
A
F
D
M
L
A
--
G
----
D
G
--
V
DL
N
T
A
G
L
V
A
V
G
H
R
V
V
H
G
G
N
T
F
Y
R
P
T
V
L
D
D
A
V
I
A
R
L
H
E
L
S
E
L
A
P
L
H
N
P
P
A
L
Q
G
I
E
V
A
R
R
L
L
P
D
I
A
H
V
A
V
F
D
T
G
F
F
H
D
L
P
P
A
A
A
T
Y
A
I
D
R
E
L
A
D
R
W
Q
I
R
R
Y
G
F
H
G
T
S
H
R
Y
V
S
E
Q
A
A
A
F
L
D
R
P
L
R
G
L
K
Q
I
V
L
H
L
G
N
G
C
S
A
S
A
I
A
G
T
R
P
L
D
T
S
M
G
L
T
P
L
E
G
L
V
M
G
T
R
S
G
D
I
D
P
S
I
V
S
Y
L
C
H
T
-
A
G
M
-
G
V
D
D
V
E
S
M
L
N
H
R
S
G
V
V
G
L
S
G
V
--
R
D
F
R
R
L
R
E
L
I
E
S
G
D
G
A
A
Q
L
A
Y
S
V
F
T
H
R
L
R
K
Y
I
G
A
Y
L
A
V
L
G
H
T
D
V
I
S
F
T
A
G
I
G
E
N
D
A
A
V
R
R
D
A
V
S
G
M
E
E
L
G
I
V
L
D
E
R
R
N
---
L
A
GG-
K
G
A
R
--
Q
----
I
S
A
D
D
S
P
I
T
V
L
V
V
P
T
N
E
E
L
A
I
A
R
D
C
V
R
V
L
G
-
8
PsiBlast_PDB
74.31
41%
-18
- C7 -
-
3R9P
3
ACKA_MYCPA
A:
[13-388]
--
R
V
L
V
I
N
S
G
S
S
S
L
K
F
Q
L
-
V
D
P
E
F
G
V
A
A
S
T
G
I
V
E
R
I
G
E
E
S
S
--------------------
P
V
P
D
H
D
A
A
----
L
R
R
A
F
D
M
L
A
--
G
D
G
--
V
D
--
L
--
N
T
A
G
L
V
A
V
G
H
R
V
V
H
G
G
N
T
F
Y
R
P
T
V
L
D
D
A
V
I
A
R
L
H
E
L
S
E
L
A
P
L
H
N
P
P
A
L
Q
G
I
E
V
A
R
R
L
L
P
D
I
A
H
V
A
V
F
D
T
G
F
F
H
D
L
P
P
A
A
A
T
Y
A
I
D
R
E
L
A
D
R
W
Q
I
R
R
Y
G
F
H
G
T
S
H
R
Y
V
S
E
Q
A
A
A
F
L
D
R
P
L
R
G
L
K
Q
I
V
L
H
L
G
N
G
C
S
A
S
A
I
A
G
T
R
P
L
D
T
S
M
G
L
T
P
L
E
G
L
V
M
G
T
R
S
G
D
I
D
P
S
I
V
S
Y
L
C
-
H
T
A
G
M
G
V
-
D
D
V
E
S
M
L
N
H
R
S
G
V
V
G
L
S
-
G
-
V
R
D
F
R
R
L
R
E
L
I
E
S
G
D
G
A
A
Q
L
A
Y
S
V
F
T
H
R
L
R
K
Y
I
G
A
Y
L
A
V
L
G
H
T
D
V
I
S
F
T
A
G
I
G
E
N
D
A
A
V
R
R
D
A
V
S
G
M
E
E
L
G
I
V
L
D
E
R
R
N
---
L
A
---
G
G
K
G
AR
Q
----
I
S
A
D
D
S
P
I
T
V
L
V
V
P
T
N
E
E
L
A
I
A
R
D
C
V
R
V
---
42
HHSearch
73.41
42%
-7
- C7 -
-
4IJN
3
ACKA_MYCS2
A:
[22-397]
M
V
T
V
L
V
V
N
S
G
S
S
S
L
K
Y
A
V
V
R
P
A
S
G
E
F
L
A
D
-
G
I
I
E
E
I
G
S
G
----------------------
A
V
P
D
H
D
A
A
----
L
R
A
A
F
D
E
L
A
--
A
----
A
G
--
L
HL
E
D
L
D
L
K
A
V
G
H
R
M
V
H
G
G
K
T
F
Y
K
P
S
V
V
D
D
E
L
I
A
K
A
R
E
L
S
P
L
A
P
L
H
N
P
P
A
I
K
G
I
E
V
A
R
K
L
L
P
D
L
P
H
I
A
V
F
D
T
A
F
F
H
D
L
P
A
P
A
S
T
Y
A
I
D
R
E
L
A
E
T
W
H
I
K
R
Y
G
F
H
G
T
S
H
E
Y
V
S
Q
Q
A
A
I
F
L
D
R
P
L
E
S
L
N
Q
I
V
L
H
L
G
N
G
A
S
A
S
A
V
A
G
G
K
A
V
D
T
S
M
G
L
T
P
M
E
G
L
V
M
G
T
R
S
G
D
I
D
P
G
V
I
M
Y
L
W
R
T
-
A
G
M
-
S
V
D
D
I
E
S
M
L
N
R
R
S
G
V
L
G
L
G
G
A
--
S
D
F
R
K
L
R
E
L
I
E
S
G
D
E
H
A
K
L
A
Y
D
V
Y
I
H
R
L
R
K
Y
I
G
A
Y
M
A
V
L
G
R
T
D
V
I
S
F
T
A
G
V
G
E
N
V
P
P
V
R
R
D
A
L
A
G
L
G
G
L
G
I
E
I
D
D
A
L
N
---
S
A
KS-
D
E
P
R
--
L
----
I
S
T
P
D
S
R
V
T
V
L
V
V
P
T
N
E
E
L
A
I
A
R
A
C
V
G
V
---
10
PsiBlast_PDB
73.27
41%
-14
- C7 -
-
4IZ9
6
ACKA_MYCA1
A:
[14-389]
--
R
V
L
V
I
N
S
G
S
S
S
L
K
F
Q
L
-
V
D
P
E
S
G
V
A
A
S
T
G
I
V
E
R
I
G
E
--
S
--------------------
P
V
P
D
H
D
A
A
----
L
R
R
A
F
D
M
L
A
--
G
D
G
--
V
D
--
L
--
N
T
A
G
L
V
A
V
G
H
R
V
V
H
G
G
N
T
F
Y
R
P
T
V
L
D
D
A
V
I
A
R
L
H
E
L
S
E
L
A
P
L
H
N
P
P
A
L
L
G
I
E
V
A
R
R
L
L
P
G
I
A
H
V
A
V
F
D
T
G
F
F
H
D
L
P
P
A
A
A
T
Y
A
I
D
R
E
L
A
D
R
W
Q
I
R
R
Y
G
F
H
G
T
S
H
R
Y
V
S
E
Q
A
A
A
F
L
D
R
P
L
R
G
L
K
Q
I
V
L
H
L
G
N
G
C
S
A
S
A
I
A
G
T
R
P
L
D
T
S
M
G
L
T
P
L
E
G
L
V
M
G
T
R
S
G
D
I
D
P
S
V
V
S
Y
L
C
-
H
T
A
G
M
G
V
-
D
D
V
E
S
M
L
N
H
R
S
G
V
V
G
L
S
-
G
-
V
R
D
F
R
R
L
R
E
L
I
E
S
G
D
G
A
A
Q
L
A
Y
S
V
F
T
H
R
L
R
K
Y
I
G
A
Y
L
A
V
L
G
H
T
D
V
I
S
F
T
A
G
I
G
E
N
D
A
A
V
R
R
D
A
V
S
G
M
E
E
L
G
I
V
L
D
E
R
R
N
---
L
P
---
G
A
K
G
AR
Q
----
I
S
A
D
D
S
P
I
T
V
L
V
V
P
T
N
E
E
L
A
I
A
R
D
C
V
R
V
---
28
PsiBlast_CBE
72.67
41%
-15
- C7 -
-
3R9P
1
ACKA_MYCPA
B:
[13-388]
--
R
V
L
V
I
N
S
G
S
S
S
L
K
F
Q
L
-
V
D
P
E
F
G
V
A
A
S
T
G
I
V
E
R
I
G
E
--
S
--------------------
P
V
P
D
H
D
A
A
----
L
R
R
A
F
D
M
L
A
--
G
D
G
--
V
D
--
L
--
N
T
A
G
L
V
A
V
G
H
R
V
V
H
G
G
N
T
F
Y
R
P
T
V
L
D
D
A
V
I
A
R
L
H
E
L
S
E
L
A
P
L
H
N
P
P
A
L
Q
G
I
E
V
A
R
R
L
L
P
D
I
A
H
V
A
V
F
D
T
G
F
F
H
D
L
P
P
A
A
A
T
Y
A
I
D
R
E
L
A
D
R
W
Q
I
R
R
Y
G
F
H
G
T
S
H
R
Y
V
S
E
Q
A
A
A
F
L
D
R
P
L
R
G
L
K
Q
I
V
L
H
L
G
N
G
C
S
A
S
A
I
A
G
T
R
P
L
D
T
S
M
G
L
T
P
L
E
G
L
V
M
G
T
R
S
G
D
I
D
P
S
I
V
S
Y
L
C
-
H
T
A
G
M
G
V
-
D
D
V
E
S
M
L
N
H
R
S
G
V
V
G
L
S
-
G
-
V
R
D
F
R
R
L
R
E
L
I
E
S
G
D
G
A
A
Q
L
A
Y
S
V
F
T
H
R
L
R
K
Y
I
G
A
Y
L
A
V
L
G
H
T
D
V
I
S
F
T
A
G
I
G
E
N
D
A
A
V
R
R
D
A
V
S
G
M
E
E
L
G
I
V
L
D
E
R
R
N
---
L
A
---
G
G
K
G
AR
Q
----
I
S
A
D
D
S
P
I
T
V
L
V
V
P
T
N
E
E
L
A
I
A
R
D
C
V
R
V
---