@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : spr1869: (2018-01-21 )
MSDSPIKYRLIKKEKHTGARLGEIITPHGTFPTPMFMPVGTQATVKTQSPEELKEMGSGIILSNTYHLWLRPGDELIARAGGLHKFMNWDQPILTDSGGFQVYSLADSRNITEEGVTFKNHLNGSKMFLSPEKAISIQNNLGSDIMMSFDECPQFYQPYDYVKKSIERTSRWAERGLKAHRRPHDQGLFGIVQGAGFEDLRRQSAHDLVSMDFSGYSIGGLAVGETHEEMNAVLDFTTQLLPENKPRYLMGVGAPDSLIDGVIRGVDMFDCVLPTRIARNGTCMTSQGRLVVKNAQFAEDFTPLDPECDCYTCNNYTRAYLRHLLKADETFGIRLTSYHNLYFLLNLMKQVRQAIMDDNLLEFREYFVEKYGYNKSGRNF
Atome Classification :
(93 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......----180----.----....----..190.......200.......210.......220...--....230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360..-.....370.......380
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MSDSP
I
K
Y
R
L
I
KKEKHTGARLG
E
I
ITPHGTFPTP
M
F
M
PVGT
Q
A
T
V
KTQ
S
P
E
E
L
K
E
MGS
G
I
I
LSN
T
Y
H
L
W
LRP
G
D
E
L
I
A
RAGG
L
H
KFMNWDQPILTDSGG
F
Q
V
Y
S
LADSRNITEEG
V
T
FKNHLNGS
K
M
F
LSPE
K
A
I
S
IQNNLG
S
D
I
M
M
S
F
D
EC
P
Q
F
Y
Q
P
Y
D
Y
V
K
K
S
I
E
R
T
S
R
W
A
E
R
G
L
K
A----HRR----P----HDQG----
L
F
G
I
VQGA
G
F
E
D
L
R
R
Q
S
AHD
L
V
S
MDFSG
Y
S
I
G
G
L
AVG
E
--
T
H
E
E
M
N
A
V
L
D
F
T
T
Q
LLPENKP
R
Y
L
M
GVGA
P
D
S
L
I
D
G
V
I
RG
V
D
M
F
D
C
VL
P
T
R
IARNG
T
C
MTSQ
G
R
L
V
V
KNAQ
F
A
EDFTPLDPEC
D
C
Y
TCN
N
Y
T
R
A
Y
L
R
H
L
L
KADET
F
G
I
R
L
TSY
H
N
L
Y
F
L
L
N
L
M
K
Q
V
R
Q
A
IMDD
N
L
L
E
F
R
-
E
Y
F
V
E
KYGYNKSGRNF
114
HHSearch
88.92
48%
-93
- C6 -
-
2ASH
3
TGT_THEMA
D:
[13-375]
-----
M
E
F
E
V
K
K
T
F
--
G
K
A
R
L
G
V
M
K
L
H
H
G
A
V
E
T
P
V
F
M
P
V
G
T
N
A
S
V
K
L
L
T
P
R
D
L
E
E
A
G
A
E
I
I
L
S
N
T
F
H
L
M
L
K
P
G
V
E
I
I
K
L
H
R
G
L
H
N
F
M
G
W
K
R
P
I
L
T
D
S
G
G
F
Q
V
F
S
L
P
K
I
R
-
I
D
D
E
G
V
V
F
R
S
P
I
D
G
S
K
V
F
L
N
P
E
I
S
M
E
V
Q
I
A
L
G
S
D
I
C
M
V
F
D
H
C
P
V
--
A
D
Y
E
E
V
K
E
A
T
E
R
T
Y
R
W
A
L
R
S
K
K
A
----
F
K
T
---------
E
N
Q
A
----
L
F
G
I
V
Q
G
G
I
Y
P
D
L
R
R
E
S
A
L
Q
L
T
S
I
G
F
D
G
Y
A
I
G
G
L
S
I
G
E
--
E
R
S
L
T
L
E
M
T
E
V
T
V
E
F
L
P
E
D
K
P
R
Y
F
M
G
G
G
S
P
E
L
I
L
E
L
V
D
R
G
V
D
M
F
D
S
V
F
P
T
R
I
A
R
H
G
T
A
L
T
W
N
G
K
L
N
L
K
A
S
Y
N
K
R
S
L
E
P
V
D
E
R
C
G
C
Y
T
C
K
N
F
T
R
S
Y
I
H
H
L
F
D
R
G
E
V
L
G
Q
I
L
L
T
I
H
N
I
N
F
M
I
S
L
M
K
E
V
R
R
S
I
E
S
G
T
F
K
E
L
K
S
K
V
V
E
V
Y
S
---------
41
PsiBlast_CBE
86.21
51%
-39
- C6 -
-
4Q4Q
5
TGT_ZYMMO
A:
[25-381]
------------------
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
A
A
T
V
K
A
L
K
P
E
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
Y
Q
V
M
S
L
S
S
L
T
K
Q
S
E
E
G
V
T
F
K
S
------
H
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
C
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
----
F
D
S
----
R
----
K
E
Q
A
E
N
A
A
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
G
F
D
G
Y
A
V
G
G
L
A
V
G
E
--
G
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
T
R
S
G
R
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
-
Q
D
F
R
A
R
Y
---------
36
PsiBlast_CBE
86.09
51%
-39
- C6 -
-
5EGR
6
TGT_ZYMMO
A:
[25-381]
------------------
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
A
A
T
V
K
A
L
K
P
E
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
Y
Q
V
M
S
---
L
T
K
Q
S
E
E
G
V
T
F
--------
H
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
C
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
----
F
D
S
----
R
----
K
E
Q
A
E
N
A
A
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
G
F
D
G
Y
A
V
G
G
L
A
V
G
E
--
G
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
T
R
S
G
R
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
-
Q
D
F
R
A
R
Y
---------
23
PsiBlast_CBE
86.03
51%
-37
- C6 -
-
5JT6
3
?
A:
[25-381]
------------------
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
A
A
T
V
K
A
L
K
P
E
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
Y
Q
V
M
S
L
S
---
K
Q
S
E
E
G
V
T
F
K
S
H
--
G
S
R
H
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
C
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
----
F
D
S
----
R
----
K
E
Q
A
EN
A
A
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
G
F
D
G
Y
A
V
G
G
L
A
V
G
E
--
G
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
T
R
S
G
R
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
-
Q
D
F
R
A
R
Y
---------
30
PsiBlast_CBE
86.00
51%
-37
- C6 -
-
5J9M
4
?
A:
[25-381]
------------------
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
A
A
T
V
K
A
L
K
P
E
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
Y
Q
V
M
S
L
S
--
T
K
Q
S
E
E
G
V
T
F
K
S
H
---
S
R
H
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
C
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
----
F
D
S
----
R
----
K
E
Q
A
E
N
A
A
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
G
F
D
G
Y
A
V
G
G
L
A
V
G
E
--
G
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
T
R
S
G
R
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
-
Q
D
F
R
A
R
Y
---------
29
PsiBlast_CBE
85.77
51%
-39
- C6 -
-
5J9N
4
?
A:
[25-381]
------------------
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
A
A
T
V
K
A
L
K
P
E
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
Y
Q
V
M
S
L
S
---
K
Q
S
E
E
G
V
T
F
K
S
H
--
G
S
R
H
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
C
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
----
F
D
S
----
R
----
K
E
Q
A
EN
A
A
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
G
F
D
G
Y
A
V
G
G
L
A
V
G
E
--
G
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
T
R
S
G
R
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
-
Q
D
F
R
A
R
Y
---------
96
PsiBlast_CBE
85.68
50%
-41
- C6 -
-
4PUL
2
TGT_ZYMMO
A:
[25-381]
------------------
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
A
A
T
V
K
A
L
K
P
E
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
N
S
G
G
Y
Q
V
M
S
L
S
S
L
T
K
Q
S
E
E
G
V
T
F
K
S
------
H
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
C
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
----
F
D
S
----
R
----
K
E
Q
A
EN
A
A
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
G
F
D
G
Y
A
V
G
G
L
A
V
G
E
--
G
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
T
R
S
G
R
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
-
Q
D
F
R
A
R
Y
---------
112
HHSearch
85.60
49%
-35
- C6 -
-
4Q8W
5
TGT_ZYMMO
A:
[12-385]
-
D
R
P
R
F
S
F
S
I
A
A
R
--
E
G
K
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
A
A
T
V
K
A
L
K
P
E
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
Y
Q
V
M
S
L
S
S
-
T
K
Q
S
E
E
G
V
T
F
K
S
H
---
S
R
H
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
C
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
----
F
D
S
R
K
E
Q
A
----
E
N
A
A
----
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
G
F
D
G
Y
A
V
G
G
L
A
V
G
E
--
G
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
T
R
S
G
R
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
Q
D
F
R
A
R
Y
F
A
--------
19
PsiBlast_PDB
85.51
51%
-37
- C6 -
-
1Q65
1
TGT_ZYMMO
A:
[25-381]
------------------
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
A
A
T
V
K
A
L
K
P
E
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
Y
Q
V
M
S
---
L
T
K
Q
S
E
E
G
V
T
F
K
S
H
L
D
G
S
R
H
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
C
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
----
F
D
S
----
R
----
K
E
Q
A
E
N
A
A
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
G
F
D
G
Y
A
V
G
G
L
A
V
G
E
--
G
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
T
R
S
G
R
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
-
Q
D
F
R
A
R
Y
---------
24
PsiBlast_CBE
85.42
51%
-36
- C6 -
-
5JT5
5
?
A:
[25-381]
------------------
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
A
A
T
V
K
A
L
K
P
E
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
Y
Q
V
M
S
L
S
--
T
K
Q
S
E
E
G
V
T
F
K
S
H
---
S
R
H
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
C
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
----
F
D
S
----
R
----
K
E
Q
A
E
N
A
A
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
G
F
D
G
Y
A
V
G
G
L
A
V
G
E
--
G
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
T
R
S
G
R
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
-
Q
D
F
R
A
R
Y
---------
7
PsiBlast_PDB
85.40
51%
-35
- C6 -
-
4LEQ
3
TGT_ZYMMO
A:
[27-383]
------------------
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
A
A
T
V
K
A
L
K
P
E
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
Y
Q
V
M
S
L
S
S
L
T
K
Q
S
E
E
G
V
T
F
K
S
-
L
D
G
S
R
H
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
C
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
----
F
D
S
----
R
----
K
E
Q
A
E
N
A
A
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
G
F
D
G
Y
A
V
G
G
L
A
V
G
E
--
G
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
T
R
S
G
R
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
-
Q
D
F
R
A
R
Y
---------
3
PsiBlast_PDB
85.36
51%
-37
- C6 -
-
4Q8V
2
TGT_ZYMMO
A:
[27-383]
------------------
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
A
A
T
V
K
A
L
K
P
E
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
Y
Q
V
M
S
L
S
S
L
T
K
Q
S
E
E
G
V
T
F
K
S
H
---
S
R
H
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
C
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
----
F
D
S
----
R
----
K
E
Q
A
E
N
A
A
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
G
F
D
G
Y
A
V
G
G
L
A
V
G
E
--
G
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
T
R
S
G
R
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
-
Q
D
F
R
A
R
Y
---------
113
HHSearch
85.33
49%
-37
- C6 -
-
5SW3
7
?
A:
[3-374]
---
P
R
F
S
F
S
I
A
A
R
E
--
G
K
A
R
T
G
T
I
-
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
A
A
T
V
K
A
L
K
P
E
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
Y
Q
V
M
S
L
S
S
L
T
K
Q
S
E
E
G
V
T
F
K
S
H
L
---
R
H
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
C
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
----
F
D
S
----
R
K
E
Q
A
E
N
A
A
----
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
G
F
D
G
Y
A
V
G
G
L
A
V
G
E
--
G
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
T
R
S
G
R
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
Q
D
F
R
A
R
Y
F
A
--------
20
PsiBlast_PDB
85.24
51%
-39
- C6 -
-
1Q66
1
TGT_ZYMMO
A:
[25-381]
------------------
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
A
A
T
V
K
A
L
K
P
E
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
Y
Q
V
M
S
---
L
T
K
Q
S
E
E
G
V
T
F
K
S
H
L
--
S
R
H
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
C
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
----
F
D
S
----
R
----
K
E
Q
A
E
N
A
A
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
G
F
D
G
Y
A
V
G
G
L
A
V
G
E
--
G
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
T
R
---
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
-
Q
D
F
R
A
R
Y
---------
9
PsiBlast_PDB
85.24
51%
-35
- C6 -
-
1F3E
1
TGT_ZYMMO
A:
[25-381]
------------------
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
A
A
T
V
K
A
L
K
P
E
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
Y
Q
V
M
S
L
S
S
L
T
K
Q
S
E
E
G
V
T
F
K
S
H
L
D
G
S
R
H
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
C
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
----
F
D
S
----
R
----
K
E
Q
A
E
N
A
A
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
G
F
D
G
Y
A
V
G
G
L
A
V
G
E
--
G
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
T
R
S
G
R
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
-
Q
D
F
R
A
R
Y
---------
10
PsiBlast_PDB
85.23
51%
-37
- C6 -
-
1K4G
1
TGT_ZYMMO
A:
[25-381]
------------------
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
A
A
T
V
K
A
L
K
P
E
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
Y
Q
V
M
S
L
S
S
L
T
K
Q
S
E
E
G
V
T
F
K
S
H
L
D
G
S
R
H
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
C
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
----
F
D
S
----
R
----
K
E
Q
A
E
N
A
A
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
G
F
D
G
Y
A
V
G
G
L
A
V
G
E
--
G
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
T
R
S
G
R
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
-
Q
D
F
R
A
R
Y
---------
40
PsiBlast_CBE
85.22
51%
-42
- C6 -
-
4Q4R
4
TGT_ZYMMO
A:
[25-381]
------------------
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
A
A
T
V
K
A
L
K
P
E
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
Y
Q
V
M
S
L
S
--
T
K
Q
S
E
E
G
V
T
F
K
-------
H
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
C
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
----
F
D
S
----
R
----
K
E
Q
A
E
N
A
A
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
G
F
D
G
Y
A
V
G
G
L
A
V
G
E
--
G
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
T
R
S
G
R
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
-
Q
D
F
R
A
R
Y
---------
4
PsiBlast_PDB
85.21
51%
-37
- C6 -
-
4Q8W
4
TGT_ZYMMO
A:
[27-383]
------------------
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
A
A
T
V
K
A
L
K
P
E
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
Y
Q
V
M
S
L
S
S
-
T
K
Q
S
E
E
G
V
T
F
K
S
H
---
S
R
H
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
C
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
----
F
D
S
----
R
----
K
E
Q
A
E
N
A
A
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
G
F
D
G
Y
A
V
G
G
L
A
V
G
E
--
G
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
T
R
S
G
R
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
-
Q
D
F
R
A
R
Y
---------
27
PsiBlast_CBE
85.18
51%
-38
- C6 -
-
5JGO
5
TGT_ZYMMO
A:
[25-381]
------------------
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
A
A
T
V
K
A
L
K
P
E
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
Y
Q
V
M
S
L
S
S
L
T
K
Q
S
E
E
G
V
T
F
K
S
H
---
S
R
H
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
C
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
----
F
D
S
----
R
----
K
E
Q
A
E
N
A
A
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
G
F
D
G
Y
A
V
G
G
L
A
V
G
E
--
G
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
T
R
S
G
R
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
-
Q
D
F
R
A
R
Y
---------
8
PsiBlast_PDB
85.18
51%
-36
- C6 -
-
1ENU
1
TGT_ZYMMO
A:
[25-381]
------------------
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
A
A
T
V
K
A
L
K
P
E
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
Y
Q
V
M
S
L
S
S
L
T
K
Q
S
E
E
G
V
T
F
K
S
H
L
D
G
S
R
H
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
C
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
----
F
D
S
----
R
----
K
E
Q
A
E
N
A
A
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
G
F
D
G
Y
A
V
G
G
L
A
V
G
E
--
G
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
T
R
S
G
R
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
-
Q
D
F
R
A
R
Y
---------
76
PsiBlast_CBE
85.15
51%
-39
* C6 *
-
5SW3
7
?
A:
[16-372]
------------------
A
R
T
G
T
I
-
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
A
A
T
V
K
A
L
K
P
E
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
Y
Q
V
M
S
L
S
S
L
T
K
Q
S
E
E
G
V
T
F
K
S
H
L
---
R
H
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
C
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
----
F
D
S
----
R
----
K
E
Q
A
E
N
A
A
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
G
F
D
G
Y
A
V
G
G
L
A
V
G
E
--
G
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
T
R
S
G
R
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
-
Q
D
F
R
A
R
Y
---------
78
PsiBlast_CBE
85.00
51%
-39
- C6 -
-
5I00
5
TGT_ZYMMO
A:
[25-381]
------------------
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
A
A
T
V
K
A
L
K
P
E
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
Y
Q
V
M
S
L
S
S
L
T
K
Q
S
E
E
G
V
T
F
K
S
H
----
R
H
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
C
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
----
F
D
S
----
R
----
K
E
Q
A
E
N
A
A
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
G
F
D
G
Y
A
V
G
G
L
A
V
G
E
--
G
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
T
R
S
G
R
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
-
Q
D
F
R
A
R
Y
---------
42
PsiBlast_CBE
84.99
51%
-42
- C6 -
-
4Q4P
3
TGT_ZYMMO
A:
[25-381]
------------------
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
A
A
T
V
K
A
L
K
P
E
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
Y
Q
V
M
S
L
S
--
T
K
Q
S
E
E
G
V
T
F
K
-------
H
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
C
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
----
F
D
S
----
R
----
K
E
Q
A
E
N
A
A
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
G
F
D
G
Y
A
V
G
G
L
A
V
G
E
--
G
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
T
R
S
G
R
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
-
Q
D
F
R
A
R
Y
---------
21
PsiBlast_CBE
84.98
51%
-37
- C6 -
-
5JXQ
4
TGT_ZYMMO
A:
[25-381]
------------------
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
A
A
T
V
K
A
L
K
P
E
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
Y
Q
V
M
S
L
S
-
L
T
K
Q
S
E
E
G
V
T
F
K
S
H
---
S
R
H
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
C
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
----
F
D
S
----
R
----
K
E
Q
A
E
N
A
A
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
G
F
D
G
Y
A
V
G
G
L
A
V
G
E
--
G
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
T
R
S
G
R
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
-
Q
D
F
R
A
R
Y
---------
67
PsiBlast_CBE
84.97
51%
-37
- C6 -
-
1S39
1
TGT_ZYMMO
A:
[25-381]
------------------
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
A
A
T
V
K
A
L
K
P
E
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
Y
Q
V
M
S
---
L
T
K
Q
S
E
E
G
V
T
F
K
S
H
---
S
R
H
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
C
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
----
F
D
S
----
R
----
K
E
Q
A
E
N
A
A
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
G
F
D
G
Y
A
V
G
G
L
A
V
G
E
--
G
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
T
R
S
G
R
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
-
Q
D
F
R
A
R
Y
---------
59
PsiBlast_CBE
84.92
51%
-38
- C6 -
-
3GC5
4
TGT_ZYMMO
A:
[25-381]
------------------
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
A
A
T
V
K
A
L
K
P
E
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
Y
Q
V
M
S
L
S
-
L
T
K
Q
S
E
E
G
V
T
F
K
S
----
S
R
H
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
C
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
----
F
D
S
----
R
----
K
E
Q
A
E
N
A
A
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
G
F
D
G
Y
A
V
G
G
L
A
V
G
E
--
G
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
T
R
S
G
R
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
-
Q
D
F
R
A
R
Y
---------
22
PsiBlast_CBE
84.90
51%
-39
- C6 -
-
5JT7
3
?
A:
[25-381]
------------------
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
A
A
T
V
K
A
L
K
P
E
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
Y
Q
V
M
S
L
S
S
---
Q
S
E
E
G
V
T
F
K
S
------
H
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
C
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
----
F
D
S
----
R
----
K
E
Q
A
E
N
A
A
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
G
F
D
G
Y
A
V
G
G
L
A
V
G
E
--
G
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
T
R
S
G
R
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
-
Q
D
F
R
A
R
Y
---------
66
PsiBlast_CBE
84.87
51%
-38
- C6 -
-
2BBF
1
TGT_ZYMMO
A:
[25-381]
------------------
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
A
A
T
V
K
A
L
K
P
E
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
Y
Q
V
M
S
---
L
T
K
Q
S
E
E
G
V
T
F
K
S
H
L
--
S
R
H
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
C
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
----
F
D
S
----
R
----
K
E
Q
A
E
N
A
A
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
G
F
D
G
Y
A
V
G
G
L
A
V
G
E
--
G
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
T
R
S
G
R
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
-
Q
D
F
R
A
R
Y
---------
84
PsiBlast_CBE
84.85
50%
-38
- C6 -
-
2Z1X
9
TGT_ZYMMO
A:
[25-381]
------------------
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
A
A
T
V
K
A
L
K
P
E
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
Y
Q
V
M
S
L
S
--
T
K
Q
S
E
E
G
V
T
F
K
S
-------
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
C
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
----
F
D
S
----
R
----
K
E
Q
A
E
N
A
A
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
G
F
D
G
Y
A
V
G
G
L
A
V
G
Q
--
G
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
T
R
S
G
R
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
-
Q
D
F
R
A
R
Y
---------
15
PsiBlast_PDB
84.78
51%
-37
- C6 -
-
1P0B
1
TGT_ZYMMO
A:
[25-381]
------------------
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
A
A
T
V
K
A
L
K
P
E
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
Y
Q
V
M
S
L
S
S
L
T
K
Q
S
E
E
G
V
T
F
K
S
H
----
R
H
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
C
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
----
F
D
S
----
R
----
K
E
Q
A
E
N
A
A
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
G
F
D
G
Y
A
V
G
G
L
A
V
G
E
--
G
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
T
R
S
G
R
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
-
Q
D
F
R
A
R
Y
---------
26
PsiBlast_CBE
84.77
51%
-37
- C6 -
-
5JSV
4
?
A:
[25-381]
------------------
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
A
A
T
V
K
A
L
K
P
E
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
Y
Q
V
M
S
L
S
S
L
T
K
Q
S
E
E
G
V
T
F
K
S
----
S
R
H
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
C
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
----
F
D
S
----
R
----
K
E
Q
A
E
N
A
A
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
G
F
D
G
Y
A
V
G
G
L
A
V
G
E
--
G
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
T
R
S
G
R
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
-
Q
D
F
R
A
R
Y
---------
25
PsiBlast_CBE
84.71
51%
-37
- C6 -
-
5JSW
11
?
A:
[25-381]
------------------
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
A
A
T
V
K
A
L
K
P
E
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
Y
Q
V
M
S
L
S
S
L
T
K
Q
S
E
E
G
V
T
F
K
S
H
--
G
S
R
H
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
C
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
----
F
D
S
----
R
----
K
E
Q
A
E
N
A
A
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
G
F
D
G
Y
A
V
G
G
L
A
V
G
E
--
G
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
T
R
S
G
R
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
-
Q
D
F
R
A
R
Y
---------
97
PsiBlast_CBE
84.70
51%
-36
- C6 -
-
4HSH
7
TGT_ZYMMO
A:
[24-380]
------------------
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
A
A
T
V
K
A
L
K
P
E
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
F
Q
V
M
S
----
T
K
Q
S
E
E
G
V
T
F
K
S
H
----
R
H
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
C
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
----
F
D
S
----
R
----
K
E
Q
A
E
N
A
A
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
G
F
D
G
Y
A
V
G
G
L
A
G
G
E
--
G
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
T
R
S
G
R
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
-
Q
D
F
R
A
R
Y
---------
57
PsiBlast_CBE
84.69
51%
-38
- C6 -
-
3RR4
3
TGT_ZYMMO
A:
[25-381]
------------------
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
A
A
T
V
K
A
L
K
P
E
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
Y
Q
V
M
S
L
S
-
L
T
K
Q
S
E
E
G
V
T
F
K
S
H
---
S
R
H
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
C
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
----
F
D
S
----
R
----
K
E
Q
A
E
N
A
A
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
G
F
D
G
Y
A
V
G
G
L
A
V
G
E
--
G
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
T
R
S
G
R
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
-
Q
D
F
R
A
R
Y
---------
92
PsiBlast_CBE
84.68
50%
-40
- C6 -
-
2OKO
15
TGT_ZYMMO
A:
[24-380]
------------------
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
A
A
T
V
K
A
L
K
P
E
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
Y
Q
V
M
S
L
S
S
L
T
K
Q
S
E
E
G
V
T
F
K
--------
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
C
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
----
F
D
S
----
R
----
K
E
Q
A
E
N
A
A
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
G
F
D
G
Y
A
V
G
G
L
A
V
G
Q
--
G
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
T
R
S
G
R
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
-
Q
D
F
R
A
R
Y
---------
28
PsiBlast_CBE
84.68
51%
-38
- C6 -
-
5JGM
7
TGT_ZYMMO
A:
[25-381]
------------------
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
A
A
T
V
K
A
L
K
P
E
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
Y
Q
V
M
S
L
S
S
L
T
K
Q
S
E
E
G
V
T
F
K
S
H
L
--
S
R
H
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
C
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
----
F
D
S
----
R
----
K
E
Q
A
E
N
A
A
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
G
F
D
G
Y
A
V
G
G
L
A
V
G
E
--
G
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
T
R
S
G
R
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
-
Q
D
F
R
A
R
Y
---------
39
PsiBlast_CBE
84.65
51%
-35
- C6 -
-
4Q4S
5
TGT_ZYMMO
A:
[25-381]
------------------
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
A
A
T
V
K
A
L
K
P
E
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
Y
Q
V
M
S
L
--
L
T
K
Q
S
E
E
G
V
T
F
K
-----
S
R
H
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
C
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
----
F
D
S
----
R
----
K
E
Q
A
E
N
A
A
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
G
F
D
G
Y
A
V
G
G
L
A
V
G
E
--
G
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
T
R
S
G
R
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
-
Q
D
F
R
A
R
Y
---------
43
PsiBlast_CBE
84.61
51%
-38
- C6 -
-
4Q4O
4
TGT_ZYMMO
A:
[25-381]
------------------
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
A
A
T
V
K
A
L
K
P
E
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
Y
Q
V
M
S
L
S
S
L
T
K
Q
S
E
E
G
V
T
F
K
-----
S
R
H
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
C
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
----
F
D
S
----
R
----
K
E
Q
A
EN
A
A
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
G
F
D
G
Y
A
V
G
G
L
A
V
G
E
--
G
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
T
R
S
G
R
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
-
Q
D
F
R
A
R
Y
---------
102
Fugue
84.58
49%
-24
- C6 -
-
1K4G
1
TGT_ZYMMO
A:
[11-382]
----
R
P
R
F
S
F
S
I
A
A
R
E
G
K
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
A
A
T
V
K
A
L
K
P
E
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
Y
Q
V
M
S
L
S
S
L
T
K
Q
S
E
E
G
V
T
F
K
S
H
L
D
G
S
R
H
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
C
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
----
F
D
S
R
K
E
Q
A
----
E
N
A
A
----
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
G
F
D
G
Y
A
V
G
G
L
A
V
--GE
G
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
T
R
S
G
R
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
-
Q
D
F
R
A
R
Y
F
--------
55
PsiBlast_CBE
84.53
51%
-37
- C6 -
-
3TLL
4
TGT_ZYMMO
A:
[25-381]
------------------
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
A
A
T
V
K
A
L
K
P
E
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
Y
Q
V
M
S
L
S
--
T
K
Q
S
E
E
G
V
T
F
K
S
H
----
R
H
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
C
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
----
F
D
S
----
R
----
K
E
Q
A
E
N
A
A
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
G
F
D
G
Y
A
V
G
G
L
A
V
G
E
--
G
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
T
R
S
G
R
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
-
Q
D
F
R
A
R
Y
---------
31
PsiBlast_CBE
84.53
51%
-36
- C6 -
-
5I09
4
TGT_ZYMMO
A:
[25-381]
------------------
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
-
A
A
T
V
K
A
L
K
P
E
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
Y
Q
V
M
S
L
S
--
T
K
Q
S
E
E
G
V
T
F
K
-----
S
R
H
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
C
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
----
F
D
S
----
R
----
K
E
Q
A
E
N
A
A
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
G
F
D
G
Y
A
V
G
G
L
A
V
G
E
--
G
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
T
R
S
G
R
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
-
Q
D
F
R
A
R
Y
---------
38
PsiBlast_CBE
84.52
51%
-34
- C6 -
-
4Q8T
4
TGT_ZYMMO
A:
[25-381]
------------------
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
A
A
T
V
K
A
L
K
P
E
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
Y
Q
V
M
S
L
S
S
L
T
K
Q
S
E
E
G
V
T
F
K
S
----
S
R
H
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
C
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
----
F
D
S
----
R
----
K
E
Q
A
E
N
A
A
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
G
F
D
G
Y
A
V
G
G
L
A
V
G
E
--
G
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
T
R
S
G
R
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
-
Q
D
F
R
A
R
Y
---------
18
PsiBlast_PDB
84.49
51%
-37
- C6 -
-
1Q63
1
TGT_ZYMMO
A:
[25-381]
------------------
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
A
A
T
V
K
A
L
K
P
E
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
Y
Q
V
M
S
L
S
--
T
K
Q
S
E
E
G
V
T
F
K
S
H
----
R
H
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
C
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
----
F
D
S
----
R
----
K
E
Q
A
E
N
A
A
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
G
F
D
G
Y
A
V
G
G
L
A
V
G
E
--
G
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
T
R
S
G
R
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
-
Q
D
F
R
A
R
Y
---------
11
PsiBlast_PDB
84.47
51%
-36
- C6 -
-
1K4H
1
TGT_ZYMMO
A:
[25-381]
------------------
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
A
A
T
V
K
A
L
K
P
E
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
Y
Q
V
M
S
L
S
S
L
T
K
Q
S
E
E
G
V
T
F
K
S
H
L
D
G
S
R
H
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
C
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
----
F
D
S
----
R
----
K
E
Q
A
E
N
A
A
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
G
F
D
G
Y
A
V
G
G
L
A
V
G
E
--
G
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
T
R
S
G
R
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
-
Q
D
F
R
A
R
Y
---------
6
PsiBlast_PDB
84.44
51%
-37
- C6 -
-
4LBU
4
TGT_ZYMMO
A:
[27-383]
------------------
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
A
A
T
V
K
A
L
K
P
E
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
Y
Q
V
M
S
L
S
S
L
T
K
Q
S
E
E
G
V
T
F
K
-----
S
R
H
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
C
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
----
F
D
S
----
R
----
K
E
Q
A
E
N
A
A
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
G
F
D
G
Y
A
V
G
G
L
A
V
G
E
--
G
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
T
R
S
G
R
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
-
Q
D
F
R
A
R
Y
---------
46
PsiBlast_CBE
84.43
51%
-37
- C6 -
-
4PUK
4
TGT_ZYMMO
A:
[25-381]
------------------
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
A
A
T
V
K
A
L
K
P
E
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
Y
Q
V
M
S
L
S
S
L
T
K
Q
S
E
E
G
V
T
F
K
S
H
---
S
R
H
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
C
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
----
F
D
S
----
R
----
K
E
Q
A
E
N
A
A
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
G
F
D
G
Y
A
V
G
G
L
A
V
G
E
--
G
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
T
R
S
G
R
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
-
Q
D
F
R
A
R
Y
---------
83
PsiBlast_CBE
84.39
50%
-37
- C6 -
-
1EFZ
1
TGT_ZYMMO
A:
[25-381]
------------------
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
A
A
T
V
K
A
L
K
P
E
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
A
G
G
Y
Q
V
M
S
L
S
S
L
T
K
Q
S
E
E
G
V
T
F
K
S
H
L
D
G
S
R
H
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
C
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
----
F
D
S
----
R
----
K
E
Q
A
E
N
A
A
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
G
F
D
G
Y
A
V
G
G
L
A
V
G
E
--
G
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
T
R
S
G
R
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
-
Q
D
F
R
A
R
Y
---------
68
PsiBlast_CBE
84.39
51%
-37
- C6 -
-
1S38
1
TGT_ZYMMO
A:
[25-381]
------------------
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
A
A
T
V
K
A
L
K
P
E
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
Y
Q
V
M
S
---
L
T
K
Q
S
E
E
G
V
T
F
K
-----
S
R
H
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
C
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
----
F
D
S
----
R
----
K
E
Q
A
E
N
A
A
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
G
F
D
G
Y
A
V
G
G
L
A
V
G
E
--
G
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
T
R
S
G
R
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
-
Q
D
F
R
A
R
Y
---------
63
PsiBlast_CBE
84.36
51%
-32
- C6 -
-
3C2Y
6
TGT_ZYMMO
A:
[25-381]
------------------
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
A
A
T
V
K
A
L
K
P
E
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
Y
Q
-------
T
K
Q
S
E
E
G
V
T
F
K
-----
S
R
H
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
C
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
----
F
D
S
----
R
----
K
E
Q
A
EN
A
A
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
G
F
D
G
Y
A
V
G
G
L
A
V
G
E
--
G
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
T
R
S
G
R
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
-
Q
D
F
R
A
R
Y
---------
2
PsiBlast_PDB
84.29
51%
-34
- C6 -
-
1OZQ
1
TGT_ZYMMO
A:
[25-381]
------------------
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
A
A
T
V
K
A
L
K
P
E
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
F
Q
V
M
S
L
S
S
L
T
K
Q
S
E
E
G
V
T
F
K
S
H
L
D
G
S
R
H
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
C
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
----
F
D
S
----
R
----
K
E
Q
A
E
N
A
A
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
G
F
D
G
Y
A
V
G
G
L
A
V
G
E
--
G
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
T
R
S
G
R
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
-
Q
D
F
R
A
R
Y
---------
44
PsiBlast_CBE
84.27
51%
-40
- C6 -
-
4Q4M
5
TGT_ZYMMO
A:
[25-381]
------------------
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
A
A
T
V
K
A
L
K
P
E
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
Y
Q
V
M
S
L
S
--
T
K
Q
S
E
E
G
V
T
F
K
S
------
H
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
C
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
----
F
D
S
----
R
----
K
E
Q
A
E
N
A
A
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
G
F
D
G
Y
A
V
G
G
L
A
V
G
E
--
G
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
T
R
S
G
R
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
-
Q
D
F
R
A
R
Y
---------
85
PsiBlast_CBE
84.25
50%
-36
- C6 -
-
2Z1W
9
TGT_ZYMMO
A:
[25-381]
------------------
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
A
A
T
V
K
A
L
K
P
E
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
Y
Q
V
M
S
---
L
T
K
Q
S
E
E
G
V
T
F
K
--------
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
C
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
----
F
D
S
----
R
----
K
E
Q
A
E
N
A
A
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
G
F
D
G
Y
A
V
G
G
L
A
V
G
Q
--
G
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
T
R
S
G
R
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
-
Q
D
F
R
A
R
Y
---------
47
PsiBlast_CBE
84.17
51%
-35
- C6 -
-
4PUJ
5
TGT_ZYMMO
A:
[25-381]
------------------
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
A
A
T
V
K
A
L
K
P
E
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
Y
Q
V
M
S
L
--
L
T
K
Q
S
E
E
G
V
T
F
K
-----
S
R
H
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
C
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
----
F
D
S
----
R
----
K
E
Q
A
E
N
A
A
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
G
F
D
G
Y
A
V
G
G
L
A
V
G
E
--
G
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
T
R
S
G
R
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
-
Q
D
F
R
A
R
Y
---------
99
PsiBlast_CBE
84.14
50%
-44
- C6 -
-
4Q8Q
1
TGT_ZYMMO
A:
[27-383]
------------------
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
A
A
T
V
K
A
L
K
P
E
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
Y
Q
V
M
S
---
L
T
K
Q
S
E
E
G
V
T
F
K
S
----
S
R
H
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
C
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
----
F
D
S
----
R
----
K
E
Q
A
E
N
A
A
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
G
F
D
G
Y
A
V
G
G
L
A
V
G
E
--
G
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
C
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
--------
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
-
Q
D
F
R
A
R
Y
---------
95
PsiBlast_CBE
84.14
50%
-37
- C6 -
-
4PUM
3
TGT_ZYMMO
A:
[27-383]
------------------
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
A
A
T
V
K
A
L
K
P
E
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
Y
Q
V
M
S
L
S
S
L
T
K
Q
S
E
E
G
V
T
F
K
S
H
---
S
R
H
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
N
E
C
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
----
F
D
S
----
R
----
K
E
Q
A
EN
A
A
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
G
F
D
G
Y
A
V
G
G
L
A
V
G
E
--
G
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
T
R
S
G
R
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
-
Q
D
F
R
A
R
Y
---------
37
PsiBlast_CBE
84.12
51%
-35
- C6 -
-
4Q8U
8
TGT_ZYMMO
A:
[25-381]
------------------
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
A
A
T
V
K
A
L
K
P
E
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
Y
Q
V
M
S
L
S
S
L
T
K
Q
S
E
E
G
V
T
F
K
S
----
S
R
H
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
C
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
----
F
D
S
----
R
----
K
E
Q
A
E
N
A
A
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
G
F
D
G
Y
A
V
G
G
L
A
V
G
E
--
G
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
T
R
S
G
R
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
-
Q
D
F
R
A
R
Y
---------
91
PsiBlast_CBE
84.09
50%
-35
- C6 -
-
4Q8M
8
TGT_ZYMMO
A:
[27-383]
------------------
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
A
A
T
V
K
A
L
K
P
E
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
Y
Q
V
M
S
L
S
S
L
T
K
Q
S
E
E
G
V
T
F
K
S
H
L
D
G
S
R
H
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
C
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
----
F
D
S
----
R
----
K
E
Q
A
E
N
A
A
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
G
F
D
G
Y
A
V
G
G
L
A
V
G
E
--
G
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
T
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
T
R
S
G
R
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
-
Q
D
F
R
A
R
Y
---------
101
PsiBlast_CBE
84.06
51%
-34
- C6 -
-
4H7Z
4
TGT_ZYMMO
A:
[25-381]
------------------
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
A
A
T
V
K
A
L
K
P
E
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
F
Q
V
M
-----
T
K
Q
S
E
E
G
V
T
F
K
S
H
L
D
G
S
R
H
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
V
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
----
F
D
S
----
R
----
K
E
Q
A
E
N
A
A
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
G
F
D
G
Y
A
V
G
G
L
A
V
G
E
--
G
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
T
R
S
G
R
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
-
Q
D
F
R
A
R
Y
---------
73
PsiBlast_CBE
83.93
51%
-36
- C6 -
-
1Q2R
2
TGT_ZYMMO
C:
[25-381]
------------------
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
A
A
T
V
K
A
L
K
P
E
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
Y
Q
V
M
S
L
S
S
L
T
K
Q
S
E
E
G
V
T
F
K
S
H
L
D
G
S
R
H
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
C
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
----
F
D
S
----
R
----
K
E
Q
A
ENAA
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
G
F
D
G
Y
A
V
G
G
L
A
V
G
E
--
G
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
T
R
S
G
R
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
-
Q
D
F
R
A
R
Y
---------
81
PsiBlast_CBE
83.89
51%
-38
- C6 -
-
1Y5X
1
TGT_ZYMMO
A:
[24-380]
------------------
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
A
A
T
V
K
A
L
K
P
E
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
Y
Q
V
M
S
L
S
S
L
T
K
Q
S
E
E
G
V
T
F
K
-----
S
R
H
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
C
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
----
F
D
S
----
R
----
K
E
Q
A
EN
A
A
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
G
F
D
G
Y
A
V
G
G
L
A
V
G
E
--
G
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
T
R
S
G
R
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
-
Q
D
F
R
A
R
Y
---------
56
PsiBlast_CBE
83.87
51%
-37
- C6 -
-
3SM0
3
TGT_ZYMMO
A:
[25-381]
------------------
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
A
A
T
V
K
A
L
K
P
E
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
Y
Q
V
M
S
---
L
T
K
Q
S
E
E
G
V
T
F
K
-----
S
R
H
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
C
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
----
F
D
S
----
R
----
K
E
Q
A
E
N
A
A
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
G
F
D
G
Y
A
V
G
G
L
A
V
G
E
--
G
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
T
R
S
G
R
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
-
Q
D
F
R
A
R
Y
---------
64
PsiBlast_CBE
83.72
51%
-37
- C6 -
-
2QII
4
TGT_ZYMMO
A:
[25-381]
------------------
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
A
A
T
V
K
A
L
K
P
E
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
Y
Q
V
M
S
L
S
S
L
T
K
Q
S
E
E
G
V
T
F
K
-----
S
R
H
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
C
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
----
F
D
S
----
R
----
K
E
Q
A
EN
A
A
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
G
F
D
G
Y
A
V
G
G
L
A
V
G
E
--
G
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
T
R
S
G
R
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
-
Q
D
F
R
A
R
Y
---------
58
PsiBlast_CBE
83.71
51%
-39
- C6 -
-
3GE7
3
TGT_ZYMMO
A:
[25-381]
------------------
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
A
A
T
V
K
A
L
K
P
E
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
Y
Q
V
M
-----
T
K
Q
S
E
E
G
V
T
F
---------
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
C
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
----
F
D
S
----
R
----
K
E
Q
A
E
N
A
A
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
G
F
D
G
Y
A
V
G
G
L
A
V
G
E
--
G
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
T
R
S
G
R
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
-
Q
D
F
R
A
R
Y
---------
13
PsiBlast_PDB
83.51
51%
-36
- C6 -
-
1Q2R
2
TGT_ZYMMO
A:
[25-381]
------------------
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
A
A
T
V
K
A
L
K
P
E
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
Y
Q
V
M
S
L
S
S
L
T
K
Q
S
E
E
G
V
T
F
K
S
H
L
D
G
S
R
H
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
C
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
----
F
D
S
----
R
----
K
E
Q
A
EN
A
A
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
G
F
D
G
Y
A
V
G
G
L
A
V
G
E
--
G
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
T
R
S
G
R
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
-
Q
D
F
R
A
R
Y
---------
100
PsiBlast_CBE
83.47
51%
-39
- C6 -
-
4HVX
4
TGT_ZYMMO
A:
[25-381]
------------------
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
A
A
T
V
K
A
L
K
P
E
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
F
Q
V
M
-------
Q
S
E
E
G
V
T
F
--------
H
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
V
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
----
F
D
S
----
R
----
K
E
Q
A
E
N
A
A
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
G
F
D
G
Y
A
V
G
G
L
A
V
G
E
--
G
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
T
R
S
G
R
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
-
Q
D
F
R
A
R
Y
---------
82
PsiBlast_CBE
83.47
51%
-40
- C6 -
-
1Y5V
3
TGT_ZYMMO
A:
[24-380]
------------------
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
A
A
T
V
K
A
L
K
P
E
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
Y
Q
V
M
-----
T
K
Q
S
E
E
G
V
T
F
K
-------
H
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
C
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
----
F
D
S
----
R
----
K
E
Q
A
EN
A
A
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
G
F
D
G
Y
A
V
G
G
L
A
V
G
E
--
G
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
T
R
S
G
R
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
-
Q
D
F
R
A
R
Y
---------
14
PsiBlast_PDB
83.43
51%
-30
- C6 -
-
1Q2S
1
TGT_ZYMMO
A:
[25-381]
------------------
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
A
A
T
V
K
A
L
K
P
E
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
Y
Q
V
M
S
L
S
S
L
T
K
Q
S
E
E
G
V
T
F
K
S
H
L
D
G
S
R
H
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
C
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
----
F
D
S
----
R
----
K
E
Q
A
E
N
A
A
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
G
F
D
G
Y
A
V
G
G
L
A
V
G
E
--
G
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
T
R
S
G
R
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
-
Q
D
F
R
A
R
Y
---------
90
PsiBlast_CBE
83.30
50%
-34
- C6 -
-
4Q8O
5
TGT_ZYMMO
A:
[27-383]
------------------
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
A
A
T
V
K
A
L
K
P
E
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
Y
Q
V
M
S
L
S
-
L
T
K
Q
S
E
E
G
V
T
F
K
-----
S
R
H
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
C
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
----
F
D
S
----
R
----
K
E
Q
A
E
N
A
A
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
G
F
D
G
Y
A
V
G
G
L
A
V
G
E
--
G
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
T
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
T
R
S
G
R
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
-
Q
D
F
R
A
R
Y
---------
17
PsiBlast_PDB
83.22
51%
-38
- C6 -
-
1P0E
1
TGT_ZYMMO
A:
[25-381]
------------------
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
A
A
T
V
K
A
L
K
P
E
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
Y
Q
V
M
S
L
S
--
T
K
Q
S
E
E
G
V
T
F
--------
H
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
C
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
----
F
D
S
----
R
----
K
E
Q
A
E
N
A
A
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
G
F
D
G
Y
A
V
G
G
L
A
V
G
E
--
G
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
T
R
S
G
R
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
-
Q
D
F
R
A
R
Y
---------
79
PsiBlast_CBE
83.17
51%
-38
- C6 -
-
2QZR
3
TGT_ZYMMO
A:
[24-380]
------------------
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
A
A
T
V
K
A
L
K
P
E
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
Y
Q
V
M
S
L
S
-----
S
E
E
G
V
T
F
K
--------
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
C
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
----
F
D
S
----
R
----
K
E
Q
A
EN
A
A
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
G
F
D
G
Y
A
V
G
G
L
A
V
G
E
--
G
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
T
R
S
G
R
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
-
Q
D
F
R
A
R
Y
---------
62
PsiBlast_CBE
83.12
51%
-43
- C6 -
-
3EOS
3
TGT_ZYMMO
A:
[25-381]
------------------
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
A
A
T
V
K
A
L
K
P
E
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
Y
Q
V
M
S
L
----
K
Q
S
E
E
G
V
T
F
--------
H
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
C
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
----
F
D
S
----
R
----
K
E
Q
A
EN
A
A
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
G
F
D
G
Y
A
V
G
G
L
A
V
G
E
--
G
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
-----
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
-
Q
D
F
R
A
R
Y
---------
70
PsiBlast_CBE
83.09
51%
-32
- C6 -
-
1Q2S
2
TGT_ZYMMO
C:
[25-381]
------------------
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
A
A
T
V
K
A
L
K
P
E
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
Y
Q
V
M
S
L
S
S
L
T
K
Q
S
E
E
G
V
T
F
K
S
H
L
D
G
S
R
H
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
C
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
----
F
D
S
----
R
----
K
E
Q
A
ENAA
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
G
F
D
G
Y
A
V
G
G
L
A
V
G
E
--
G
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
T
R
S
G
R
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
-
Q
D
F
R
A
R
Y
---------
51
PsiBlast_CBE
83.07
51%
-41
- C6 -
-
4GH3
1
TGT_ZYMMO
A:
[25-381]
------------------
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
--
A
T
V
K
A
L
K
P
E
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
Y
Q
V
M
S
-----
K
Q
S
E
E
G
V
T
F
---------
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
C
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
----
F
D
S
----
R
----
K
E
Q
A
EN
A
A
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
G
F
D
G
Y
A
V
G
G
L
A
V
G
E
--
G
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
T
R
S
G
R
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
-
Q
D
F
R
A
R
Y
---------
52
PsiBlast_CBE
82.98
51%
-38
- C6 -
-
4GH1
2
TGT_ZYMMO
A:
[25-381]
------------------
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
A
A
T
V
K
A
L
K
P
E
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
Y
Q
V
M
------
K
Q
S
E
E
G
V
T
F
---------
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
C
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
----
F
D
S
----
R
----
K
E
Q
A
E
N
A
A
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
G
F
D
G
Y
A
V
G
G
L
A
V
G
E
--
G
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
T
R
S
G
R
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
-
Q
D
F
R
A
R
Y
---------
50
PsiBlast_CBE
82.93
51%
-39
- C6 -
-
4GI4
1
TGT_ZYMMO
A:
[25-381]
------------------
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
A
A
T
V
K
A
L
K
P
E
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
Y
Q
V
M
S
L
----
K
Q
S
E
E
G
V
T
F
---------
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
C
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
----
F
D
S
----
R
----
K
E
Q
A
EN
A
A
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
G
F
D
G
Y
A
V
G
G
L
A
V
G
E
--
G
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
T
R
S
G
R
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
-
Q
D
F
R
A
R
Y
---------
33
PsiBlast_CBE
82.84
51%
-38
- C6 -
-
5I07
6
TGT_ZYMMO
A:
[25-381]
------------------
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
A
A
--------
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
Y
Q
V
M
S
L
S
S
L
T
K
Q
S
E
E
G
V
T
F
K
S
H
L
D
G
S
R
H
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
C
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
----
F
D
S
----
R
----
K
E
Q
A
EN
A
A
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
G
F
D
G
Y
A
V
G
G
L
A
V
G
E
--
G
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
T
R
S
G
R
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
-
Q
D
F
R
A
R
Y
---------
65
PsiBlast_CBE
82.78
51%
-38
- C6 -
-
2PWU
4
TGT_ZYMMO
A:
[25-381]
------------------
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
A
A
T
V
K
A
L
K
P
E
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
Y
Q
V
M
S
L
S
---
K
Q
S
E
E
G
V
T
F
K
S
-------
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
C
T
-----
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
----
F
D
S
----
R
----
K
E
Q
A
E
N
A
A
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
G
F
D
G
Y
A
V
G
G
L
A
V
G
E
--
G
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
T
R
S
G
R
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
-
Q
D
F
R
A
R
Y
---------
87
PsiBlast_CBE
82.71
50%
-39
- C6 -
-
2PWV
7
TGT_ZYMMO
A:
[25-381]
------------------
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
A
A
T
V
K
A
L
K
P
E
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
Y
Q
V
M
S
L
----
K
Q
S
E
E
G
V
T
F
K
--------
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
C
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
----
F
D
S
----
R
----
K
E
Q
A
E
N
A
A
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
G
F
D
G
Y
A
V
G
G
L
A
V
G
Q
--
G
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
T
R
S
G
R
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
-
Q
D
F
R
A
R
Y
---------
88
PsiBlast_CBE
82.69
50%
-39
- C6 -
-
2POT
8
TGT_ZYMMO
A:
[25-381]
------------------
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
A
A
T
V
K
A
L
K
P
E
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
Y
-----------
S
E
E
G
V
T
F
K
-------
H
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
C
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
----
F
D
S
----
R
----
K
E
Q
A
EN
A
A
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
G
F
D
G
Y
A
V
G
G
L
A
V
G
Q
--
G
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
T
R
S
G
R
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
-
Q
D
F
R
A
R
Y
---------
98
PsiBlast_CBE
82.56
50%
-43
- C6 -
-
1PXG
9
TGT_ZYMMO
A:
[24-380]
------------------
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
A
A
T
V
K
A
L
K
P
E
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
Y
Q
V
M
S
L
S
S
L
T
K
Q
S
E
E
G
V
T
F
K
S
H
L
D
G
S
R
H
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
C
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
F
D
S
R
K
E
Q
----
A
----
E
N
A
A
----
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
G
F
D
G
Y
A
V
G
G
L
A
V
G
E
--
G
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
E
C
V
--------
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
-
Q
D
F
R
A
R
Y
---------
48
PsiBlast_CBE
82.35
51%
-38
- C6 -
-
4GKT
2
TGT_ZYMMO
A:
[25-381]
------------------
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
--
A
T
V
K
A
L
K
P
E
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
Y
Q
-------
T
K
Q
S
E
E
G
V
T
F
---------
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
C
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
----
F
D
S
----
R
----
K
E
Q
A
E
N
A
A
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
G
F
D
G
Y
A
V
G
G
L
A
V
G
E
--
G
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
T
R
S
G
R
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
-
Q
D
F
R
A
R
Y
---------
32
PsiBlast_CBE
82.11
51%
-40
- C6 -
-
5I07
4
TGT_ZYMMO
B:
[25-381]
------------------
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
A
A
--------
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
Y
Q
V
M
S
L
S
S
L
T
K
Q
S
E
E
G
V
T
F
K
S
H
L
D
G
S
R
H
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
C
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
----
F
D
S
----
R
----
K
E
Q
A
ENAA
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
G
F
D
G
Y
A
V
G
G
L
A
V
G
E
--
G
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
T
R
S
G
R
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
-
Q
D
F
R
A
R
Y
---------
77
PsiBlast_CBE
81.78
51%
-43
- C6 -
-
5I02
6
TGT_ZYMMO
A:
[25-381]
------------------
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
A
A
-------------
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
Y
Q
V
M
S
L
S
S
L
T
K
Q
S
E
E
G
V
T
F
K
-------
H
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
C
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
----
F
D
S
----
R
----
K
E
Q
A
E
N
A
A
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
G
F
D
G
Y
A
V
G
G
L
A
V
G
E
--
G
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
T
R
S
G
R
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
-
Q
D
F
R
A
R
Y
---------
61
PsiBlast_CBE
81.76
51%
-46
- C6 -
-
3EOU
3
TGT_ZYMMO
A:
[25-381]
------------------
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
A
A
T
V
K
A
L
K
P
E
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
Y
Q
V
M
-------
Q
S
E
E
G
V
T
F
----------
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
C
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
----
F
D
S
----
R
----
K
E
Q
A
E
N
A
A
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
G
F
D
G
Y
A
V
G
G
L
A
V
G
E
--
G
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
------
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
-
Q
D
F
R
A
R
Y
---------
60
PsiBlast_CBE
81.74
51%
-34
- C6 -
-
3GC4
6
TGT_ZYMMO
A:
[25-381]
------------------
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
A
A
T
V
K
A
L
K
P
E
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
Y
Q
----------
S
E
E
G
V
T
F
---------
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
C
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
----
F
D
S
----
R
----
K
E
Q
A
EN
A
A
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
G
F
D
G
Y
A
V
G
G
L
A
V
G
E
--
G
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
T
R
S
G
R
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
-
Q
D
F
R
A
R
Y
---------
5
PsiBlast_PDB
81.44
51%
-43
- C6 -
-
4KWO
2
TGT_ZYMMO
A:
[27-383]
------------------
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
A
A
-------------
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
Y
Q
V
M
S
L
S
--
T
K
Q
S
E
E
G
V
T
F
K
-------
H
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
C
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
----
F
D
S
----
R
----
K
E
Q
A
E
N
A
A
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
G
F
D
G
Y
A
V
G
G
L
A
V
G
E
--
G
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
T
R
S
G
R
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
-
Q
D
F
R
A
R
Y
---------
35
PsiBlast_CBE
81.39
51%
-39
- C6 -
-
5I03
4
TGT_ZYMMO
A:
[25-381]
------------------
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
A
A
T
V
K
A
L
------
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
Y
Q
V
M
S
L
S
--
T
K
Q
S
E
E
G
V
T
F
--------
H
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
C
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
----
F
D
S
----
R
----
K
E
Q
A
EN
A
A
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
G
F
D
G
Y
A
V
G
G
L
A
V
G
E
--
G
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
T
R
S
G
R
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
-
Q
D
F
R
A
R
Y
---------
34
PsiBlast_CBE
81.21
51%
-35
- C6 -
-
5I06
5
TGT_ZYMMO
A:
[25-381]
------------------
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
A
A
T
V
K
A
---------
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
Y
Q
V
M
S
L
S
--
T
K
Q
S
E
E
G
V
T
F
K
-------
H
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
C
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
----
F
D
S
----
R
----
K
E
Q
A
EN
A
A
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
G
F
D
G
Y
A
V
G
G
L
A
V
G
E
--
G
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
--
L
P
T
R
S
G
R
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
-
Q
D
F
R
A
R
Y
---------
80
PsiBlast_CBE
80.93
51%
-41
- C6 -
-
1Y5X
1
TGT_ZYMMO
D:
[24-380]
------------------
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
---------------
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
Y
Q
V
M
S
L
S
S
L
T
K
Q
S
E
E
G
V
T
F
K
-----
S
R
H
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
C
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
----
F
D
S
----
R
----
K
E
Q
A
ENAA
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
G
F
D
G
Y
A
V
G
G
L
A
V
G
E
--
G
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
T
R
S
G
R
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
-
Q
D
F
R
A
R
Y
---------
93
PsiBlast_CBE
80.79
51%
-37
- C6 -
-
3BLD
3
TGT_ZYMMO
A:
[25-381]
------------------
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
A
A
T
V
K
A
L
K
P
E
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
F
Q
V
M
S
------
Q
S
E
E
G
V
T
F
K
S
--------
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
C
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
----
F
D
S
----
R
----
K
E
Q
A
E
N
A
A
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
G
F
D
G
Y
A
V
G
G
L
A
G
G
E
--
G
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
----------
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
-
Q
D
F
R
A
R
Y
---------
53
PsiBlast_CBE
79.41
51%
-45
- C6 -
-
4FR6
1
TGT_ZYMMO
A:
[25-381]
------------------
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
----------------
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
Y
Q
V
M
S
L
S
----
Q
S
E
E
G
V
T
F
----------
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
C
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
----
F
D
S
----
R
----
K
E
Q
A
EN
A
A
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
G
F
D
G
Y
A
V
G
G
L
A
V
G
E
--
G
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
T
R
S
G
R
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
-
Q
D
F
R
A
R
Y
---------
49
PsiBlast_CBE
79.27
51%
-40
- C6 -
-
4GIY
1
TGT_ZYMMO
A:
[25-381]
------------------
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
----------------
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
Y
Q
V
M
S
L
S
--
T
K
Q
S
E
E
G
V
T
F
----------
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
C
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
----
F
D
S
----
R
----
K
E
Q
A
EN
A
A
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
G
F
D
G
Y
A
V
G
G
L
A
V
G
E
--
G
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
T
R
S
G
R
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
-
Q
D
F
R
A
R
Y
---------
54
PsiBlast_CBE
78.69
51%
-45
- C6 -
-
4FR1
1
TGT_ZYMMO
A:
[25-381]
------------------
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
-----------------
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
Y
Q
V
M
-------
Q
S
E
E
G
V
T
F
----------
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
C
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
----
F
D
S
----
R
----
K
E
Q
A
E
N
A
A
L
F
G
I
Q
Q
G
S
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--
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---------