@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : spr1902: (2018-01-22 )
MEKQTVAVLGPGSWGTALSQVLNDNGHEVRIWGNLPEQINEINTHHTNKHYFKDVVLDENIIAYTDLAETLKNVDAILFVVPTKVTRLVAQQVAQTLDHKVIIMHASKGLEPDSHKRLSTILEEEIPEHLRSDIVVVSGPSHAEETIVRDLTLITAASKDLQTAQYVQELFSNHYFRLYTNTDVIGVETAGALKNIIAVGAGALHGLGFGDNAKAAIIARGLAEITRLGVALGASPLTYSGLSGVGDLIVTGTSIHSRNWRAGDALGRGESLADIEANMGMVIEGISTTRAAYELAQELGVYMPITQAIYQVIYHGTNIKDAIYDIMNNEFKAENEWS
Atome Classification :
(20 SA)
----.........10........20....--..--------.-------.30.-------......-----.40------........50........60........70........80........90.-----......-----.100.......110-....--....120.......130........140.......150.....---..160---------..------.....170--..--.....180.......190.......200.......210.......220.......230---..--...---..240........250.......260...-----...-.-.270.......--280........290.......300-.--.......310.......320.......330......---
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
----MEK
Q
T
V
A
V
LGPG
S
W
G
T
A
L
S
Q
V
L
NDN--G
H
--------
E
-------
V
R
I
W-------GNL
P
E
Q
-----
I
N
E
------
I
NTHHTN
K
H
Y
F
K
D
VVLDEN
I
I
A
Y
T
D
L
A
E
T
L
KNV
D
A
I
L
F
VV
P
T
K
V
T
R
L
V
A
Q
Q
-----
V
A
Q
TLD-----H
K
V
I
I
M
HASKGLE--PD
S
H
--
K
R
L
S
T
I
L
E
E
E
I
P
E
H
L
-RS
D
I
V
V
VSGPS
H
A
E
E
T
I
V
R
D
L
T
L
I
TAA---SKD
L
Q
---------
T
A
------
Q
Y
V
Q
E
L
F
S--N
H
--
Y
F
R
L
Y
TNT
D
V
I
G
V
E
T
A
G
A
L
K
N
I
I
A
V
G
A
G
A
LHGLGFGDN
A
K
A
A
I
I
A
R
G
L
A
E
I
T
R
L
G
V
AL---GA--SPL---TYS-GLSGVG
D
L
I
V
TG
T
S
IHSRNWR-AGD-----ALG-R-GES
L
A
D
I
EANM--
G
-
M
V
I
EGI
S
T
T
R
A
A
Y
E
L
A
Q
E
LGV--Y--M
P
I
T
Q
A
I
Y
Q
V
I
YHGT
N
I
K
D
A
I
Y
D
I
MNNEFKAENEWS---
44
HHSearch
72.45
30%
-
- C1 -
-
4FGW
-
GPD1_YEAST
B:
[33-385]
-----
K
P
F
K
V
T
V
I
G
S
G
N
W
G
T
T
I
A
K
V
V
A
E
N
--
C
K
GYPEVFAP
I
-------
V
Q
M
W
-------
V
F
E
E
E
I
NGEKL
T
E
I
------
I
N
T
R
H
Q
N
V
K
Y
L
P
G
I
T
L
P
D
N
L
V
A
N
P
D
L
I
D
S
V
K
D
V
D
I
I
V
F
N
I
P
H
Q
F
L
P
R
I
C
S
Q
-----
L
K
G
H
V
D
-----
S
H
V
R
A
I
S
C
L
K
G
F
E
--
V
G
A
K
GV
Q
L
L
S
S
Y
I
T
E
E
L
G
-----
I
Q
C
G
A
L
S
G
A
N
I
A
T
E
V
A
Q
E
H
W
S
E
T
T
V
A
---
Y
H
I
P
K
DFRGEGKDV
D
H
------
K
V
L
K
A
L
F
H
--
R
P
--
Y
F
H
V
S
V
I
E
D
V
A
G
I
S
I
C
G
A
L
K
N
V
V
A
L
G
C
G
F
V
E
G
L
G
W
G
N
N
A
S
A
A
I
Q
R
V
G
L
G
E
I
I
R
F
G
Q
M
F
---
F
P
ES
R
E
E
---
T
Y
Y
Q
E
S
A
G
V
A
D
L
I
T
T
C
A
G
--
G
R
N
V
K
-
V
A
R
-----
L
M
A
T
S
-
G
K
D
A
W
E
C
E
K
E
L
L-
N
G
Q
S
A
Q
G
L
I
T
C
K
E
V
H
E
W
L
E
T
C
G
S
VE
D
--
F
P
L
F
E
A
V
Y
Q
I
V
Y
N
N
Y
P
M
K
N
L
P
D
M
I
E
E
-------------
15
PsiBlast_PDB
71.79
29%
-
- C1 -
-
4FGW
-
GPD1_YEAST
A:
[37-378]
---------
V
T
V
I
G
S
G
N
W
G
T
T
I
A
K
V
V
A
E
N
C
K
G
Y
--------
P
EVFAP
I
-
V
Q
M
W
--------
V
F
E
E
E
-----
I
N
G
EK
L
T
E
I
I
N
T
R
H
Q
N
V
K
Y
L
P
G
I
T
L
P
D
N
L
V
A
N
P
D
L
I
D
S
V
K
D
V
D
I
I
V
F
N
I
P
H
Q
F
L
P
R
I
C
S
Q
-----
L
K
G
H
V
D
-----
S
H
V
R
A
I
S
C
L
K
G
F
E
--
V
G
A
----
K
G
V
Q
L
L
S
S
Y
I
T
E
E
L
-
G
I
Q
C
G
A
L
S
G
A
N
I
A
T
E
V
A
Q
E
H
W
S
E
T
T
V
A
Y
H
I
P
K
D
F
R
---------
G
E
GKDVD
H
K
V
L
K
A
L
F
H
--
R
P
--
Y
F
H
V
S
V
I
E
D
V
A
G
I
S
I
C
G
A
L
K
N
V
V
A
L
G
C
G
F
V
E
G
L
G
W
G
N
N
A
S
A
A
I
Q
R
V
G
L
G
E
I
I
R
F
G
Q
M
F
FPE
S
R
--
E
E
T
---
Y
Y
Q
-
E
S
A
G
V
A
D
L
I
T
T
C
A
G
--
G
R
N
V
K
-
V
A
R
-----
L
M
A
T
S
-
G
K
D
A
W
E
C
E
K
E
L
LN
G
-
Q
S
A
Q
G
L
I
T
C
K
E
V
H
E
W
L
E
T
C
G
S
--
V
ED
F
P
L
F
E
A
V
Y
Q
I
V
Y
N
N
Y
P
M
K
N
--------------------
46
HHSearch
70.81
35%
-72
- C1 -
-
3K96
1
GPDA_COXBU
A:
[28-352]
-----
F
K
H
P
I
A
I
L
G
A
G
S
W
G
T
A
L
A
L
V
L
A
R
K
--
G
Q
--------
K
-------
V
R
L
W
-------
S
Y
E
S
D
H
-----
V
D
E
------
M
Q
A
E
G
V
N
N
R
Y
L
P
N
Y
P
F
P
E
T
L
K
A
Y
C
D
L
K
A
S
L
E
G
V
T
D
I
L
I
V
V
P
S
F
A
F
H
E
V
I
T
R
-----
M
K
P
L
I
D
-----
A
K
T
R
I
A
W
G
T
K
G
L
A
--
K
G
S
---
R
L
L
H
E
V
V
A
T
E
L
G
----
Q
V
P
M
A
V
I
S
G
P
S
L
A
T
E
V
A
A
N
L
P
T
A
V
S
L
A
---
S
N
N
S
Q
---------
F
S
------
K
D
L
I
E
R
L
H
--
G
Q
--
R
F
R
V
Y
K
N
D
D
M
I
G
V
E
L
C
G
S
V
K
N
I
L
A
I
A
T
G
I
S
D
G
L
K
L
G
S
N
A
R
A
A
L
I
T
R
G
L
T
E
M
G
R
L
V
S
V
F
---
G
G
--
K
Q
E
---
T
L
T
-
G
L
A
G
L
G
D
L
V
L
T
C
T
D
N
Q
S
R
N
R
R
F
G
L
A
L
G
E
GV
D
K
K
-
E
-------
A
Q
Q
A
I
--
G
-
Q
A
I
E
G
L
Y
N
T
D
Q
V
H
A
L
A
Q
K
H
A
I
--
E
--
M
P
L
T
F
Q
V
H
R
I
L
H
E
D
L
D
P
Q
Q
A
V
Q
E
L
L
E
R
S
-----------
22
PsiBlast_CBE
70.40
35%
-64
- C1 -
-
3K96
2
GPDA_COXBU
B:
[29-351]
------
K
H
P
I
A
I
L
G
A
G
S
W
G
T
A
L
A
L
V
L
A
R
K
--
G
Q
--------
K
-------
V
R
L
W
-------
S
Y
E
S
D
H
-----
V
D
E
------
M
Q
A
E
G
V
N
N
R
Y
L
P
N
Y
P
F
P
E
T
L
K
A
Y
C
D
L
K
A
S
L
E
G
V
T
D
I
L
I
V
V
P
S
F
A
F
H
E
V
I
T
R
-----
M
K
P
L
I
D
-----
A
K
T
R
I
A
W
G
T
K
G
L
A
--
K
G
S
R
-------
L
L
H
E
V
V
A
T
E
L
G
Q
V
P
M
A
V
I
S
G
P
S
L
A
T
E
V
A
A
N
L
P
T
A
V
S
L
A
---
S
N
N
S
Q
---------
F
S
------
K
D
L
I
E
R
L
H
--
G
Q
--
R
F
R
V
Y
K
N
D
D
M
I
G
V
E
L
C
G
S
V
K
N
I
L
A
I
A
T
G
I
S
D
G
L
K
L
G
S
N
A
R
A
A
L
I
T
R
G
L
T
E
M
G
R
L
V
S
V
F
---
G
G
--
K
Q
E
---
T
L
T
-
G
L
A
G
L
G
D
L
V
L
T
C
T
D
N
Q
S
R
N
R
R
-
F
G
L
-----
A
L
G
-
E
-
G
V
D
K
K
E
A
Q
Q
A
I
--
G
-
Q
A
I
E
G
L
Y
N
T
D
Q
V
H
A
L
A
Q
K
H
A
I
--
E
--
M
P
L
T
F
Q
V
H
R
I
L
H
E
D
L
D
P
Q
Q
A
V
Q
E
L
L
E
R
------------
45
HHSearch
70.37
35%
-74
- C1 -
-
3K96
2
GPDA_COXBU
B:
[28-351]
-----
F
K
H
P
I
A
I
L
G
A
G
S
W
G
T
A
L
A
L
V
L
A
R
K
--
G
Q
--------
K
-------
V
R
L
W
-------
S
Y
E
S
D
H
-----
V
D
E
------
M
Q
A
E
G
V
N
N
R
Y
L
P
N
Y
P
F
P
E
T
L
K
A
Y
C
D
L
K
A
S
L
E
G
V
T
D
I
L
I
V
V
P
S
F
A
F
H
E
V
I
T
R
-----
M
K
P
L
I
D
-----
A
K
T
R
I
A
W
G
T
K
G
L
A
--
K
G
S
---
R
L
L
H
E
V
V
A
T
E
L
G
----
Q
V
P
M
A
V
I
S
G
P
S
L
A
T
E
V
A
A
N
L
P
T
A
V
S
L
A
---
S
N
N
S
Q
---------
F
S
------
K
D
L
I
E
R
L
H
--
G
Q
--
R
F
R
V
Y
K
N
D
D
M
I
G
V
E
L
C
G
S
V
K
N
I
L
A
I
A
T
G
I
S
D
G
L
K
L
G
S
N
A
R
A
A
L
I
T
R
G
L
T
E
M
G
R
L
V
S
V
F
---
G
G
--
K
Q
E
---
T
L
T
-
G
L
A
G
L
G
D
L
V
L
T
C
T
D
N
Q
S
R
N
R
R
F
G
L
A
LGEGV
D
K
K
-
E
-------
A
Q
Q
A
I
--
G
-
Q
A
I
E
G
L
Y
N
T
D
Q
V
H
A
L
A
Q
K
H
A
I
--
E
--
M
P
L
T
F
Q
V
H
R
I
L
H
E
D
L
D
P
Q
Q
A
V
Q
E
L
L
E
R
------------
42
HHSearch
70.31
39%
-109
- C1 -
-
1Z82
7
?
A:
[14-325]
------
E
M
R
F
F
V
L
G
A
G
S
W
G
T
V
F
A
Q
M
L
H
E
N
--
G
E
--------
E
-------
V
I
L
W
-------
A
R
R
K
E
I
-----
V
D
L
------
I
N
V
S
H
T
S
P
-
Y
V
E
E
S
--
K
I
T
V
R
A
T
N
D
L
E
E
-
I
K
K
E
D
I
L
V
I
A
I
P
V
Q
Y
I
R
E
H
L
L
R
-----
L
P
V
--------
K
P
S
M
V
L
N
L
S
K
G
I
E
--
I
K
T
G
--
K
R
V
S
E
I
V
E
E
I
L
G
-----
C
P
Y
A
V
L
S
G
P
S
H
A
E
E
V
A
K
K
L
P
T
A
V
T
L
A
---
G
E
N
S
------------------
K
E
L
Q
K
R
I
S
--
T
E
--
Y
F
R
V
Y
T
C
E
D
V
V
G
V
E
I
A
G
A
L
K
N
V
I
A
I
A
A
G
I
L
D
G
F
G
G
W
D
N
A
K
A
A
L
E
T
R
G
I
Y
E
I
A
R
F
G
M
F
F
---
G
A
--
D
Q
K
---
T
F
M
-
G
L
A
G
I
G
D
L
M
V
T
C
N
S
R
Y
S
R
N
R
R
-
F
G
E
-----
L
I
A
-
R
-
G
F
N
P
L
K
L
L
E
S
S
--
N
-
Q
V
V
E
G
A
F
T
V
K
A
V
M
K
I
A
K
E
N
K
I
--
D
--
M
P
I
S
E
E
V
Y
R
V
V
Y
E
G
K
P
P
L
Q
S
M
R
D
L
M
R
-------------
9
PsiBlast_PDB
70.10
35%
-60
- C1 -
-
3K96
1
GPDA_COXBU
A:
[29-352]
------
K
H
P
I
A
I
L
G
A
G
S
W
G
T
A
L
A
L
V
L
A
R
K
--
G
Q
--------
K
-------
V
R
L
W
-------
S
Y
E
S
D
H
-----
V
D
E
------
M
Q
A
E
G
V
N
N
R
Y
L
P
N
Y
P
F
P
E
T
L
K
A
Y
C
D
L
K
A
S
L
E
G
V
T
D
I
L
I
V
V
P
S
F
A
F
H
E
V
I
T
R
-----
M
K
P
L
I
D
-----
A
K
T
R
I
A
W
G
T
K
G
L
A
--
K
G
S
R
-------
L
L
H
E
V
V
A
T
E
L
G
Q
V
P
M
A
V
I
S
G
P
S
L
A
T
E
V
A
A
N
L
P
T
A
V
S
L
A
---
S
N
N
S
Q
---------
F
S
------
K
D
L
I
E
R
L
H
--
G
Q
--
R
F
R
V
Y
K
N
D
D
M
I
G
V
E
L
C
G
S
V
K
N
I
L
A
I
A
T
G
I
S
D
G
L
K
L
G
S
N
A
R
A
A
L
I
T
R
G
L
T
E
M
G
R
L
V
S
V
F
---
G
G
--
K
Q
E
---
T
L
T
-
G
L
A
G
L
G
D
L
V
L
T
C
T
D
N
Q
S
R
N
R
R
-
F
G
L
-----
A
L
G
-
E
-
G
V
D
K
K
E
A
Q
Q
A
I
--
G
-
Q
A
I
E
G
L
Y
N
T
D
Q
V
H
A
L
A
Q
K
H
A
I
--
E
--
M
P
L
T
F
Q
V
H
R
I
L
H
E
D
L
D
P
Q
Q
A
V
Q
E
L
L
E
R
S
-----------
39
HHSearch
68.04
35%
-45
* C1 *
-
1N1E
1
GPDA_LEIME
B:
[14-350]
-----
Y
L
N
K
A
V
V
F
G
S
G
A
F
G
T
A
L
A
M
V
L
S
K
K
--
C
R
--------
E
-------
V
C
V
W
-------
H
M
N
E
E
E
-----
V
R
L
------
V
N
E
K
R
E
N
V
L
F
L
K
G
V
Q
L
A
S
N
I
T
F
T
S
D
V
E
K
A
Y
N
G
A
E
I
I
L
F
V
I
P
T
Q
F
L
R
G
F
F
E
K
-----
S
G
G
N
L
I
AYAKE
K
Q
V
P
V
L
V
C
T
K
G
I
E
--
R
S
T
L
--
K
F
P
A
E
I
I
G
E
F
L
P
S
----
P
L
L
S
V
L
A
G
P
S
F
A
I
E
V
A
T
G
V
F
T
C
V
S
I
A
---
S
A
D
I
N
---------
V
A
------
R
R
L
Q
R
I
M
S
--
T
G
DR
S
F
V
C
W
A
T
T
D
T
V
G
C
E
V
A
S
A
V
K
N
V
L
A
I
G
S
G
V
A
N
G
L
G
M
G
L
N
A
R
A
A
L
I
M
R
G
L
L
E
I
R
D
L
T
A
A
L
---
G
G
--
D
G
S
---
A
V
F
-
G
L
A
G
L
G
D
L
Q
L
T
C
S
S
E
L
S
R
N
F
T
-
V
G
K
-----
K
L
G
-
K
-
G
L
P
I
E
E
I
Q
R
T
S
--
K
-
A
V
A
E
G
V
A
T
A
D
P
L
M
R
L
A
K
Q
L
K
V
--
K
--
M
P
L
C
H
Q
I
Y
E
I
V
Y
K
K
K
N
P
R
D
A
L
A
D
L
L
S
C
G
L
Q
D
E
-------
1
PsiBlast_PDB
67.67
37%
-109
- C1 -
-
1Z82
7
?
A:
[19-325]
-----------
V
L
G
A
G
S
W
G
T
V
F
A
Q
M
L
H
E
N
--
G
E
--------
E
-------
V
I
L
W
-------
A
R
R
K
E
I
-----
V
D
L
------
I
N
V
S
H
T
S
P
Y
V
E
E
S
K
I
---
T
V
R
A
T
N
D
L
-
E
E
I
K
K
E
D
I
L
V
I
A
I
P
V
Q
Y
I
R
---
E
H
-----
L
L
R
L
P
V
-----
K
P
S
M
V
L
N
L
S
K
G
I
E
--
I
K
T
G
--
K
R
V
S
E
I
V
E
E
----
I
L
-
G
C
P
Y
A
V
L
S
G
P
S
H
A
E
E
V
A
K
K
L
P
T
A
V
T
L
A
---
G
---
E
---------
N
S
------
K
E
L
Q
K
R
I
S
--
T
E
--
Y
F
R
V
Y
T
C
E
D
V
V
G
V
E
I
A
G
A
L
K
N
V
I
A
I
A
A
G
I
L
D
G
F
G
G
W
D
N
A
K
A
A
L
E
T
R
G
I
Y
E
I
A
R
F
G
M
F
F
---
G
A
--
D
Q
K
---
T
F
M
-
G
L
A
G
I
G
D
L
M
V
T
C
N
S
R
Y
S
R
N
R
R
-
F
G
E
-----
L
I
A
-
R
-
G
F
N
P
L
K
L
L
E
S
S
--
N
-
Q
V
V
E
G
A
F
T
V
K
A
V
M
K
I
A
K
E
N
K
I
--
D
--
M
P
I
S
E
E
V
Y
R
V
V
Y
E
G
K
P
P
L
Q
S
M
R
D
L
M
R
-------------
40
HHSearch
66.93
35%
-46
- C1 -
-
1EVY
1
GPDA_LEIME
A:
[14-350]
-----
Y
L
N
K
A
V
V
F
G
S
G
A
F
G
T
A
L
A
M
V
L
S
K
K
--
C
R
--------
E
-------
V
C
V
W
-------
H
M
N
E
E
E
-----
V
R
L
------
V
N
E
K
R
E
N
V
L
F
L
K
G
V
Q
L
A
S
N
I
T
F
T
S
D
V
E
K
A
Y
N
G
A
E
I
I
L
F
V
I
P
T
Q
F
L
R
G
F
F
E
K
-----
S
G
G
N
L
I
A
Y
A
K
E
K
Q
V
P
V
L
V
C
T
K
G
I
E
--
R
S
T
L
--
K
F
P
A
E
I
I
G
E
F
L
P
S
----
P
L
L
S
V
L
A
G
P
S
F
A
I
E
V
A
T
G
V
F
T
C
V
S
I
A
---
S
A
D
I
N
---------
V
A
------
R
R
L
Q
R
I
M
S
--
T
G
DR
S
F
V
C
W
A
T
T
D
T
V
G
C
E
V
A
S
A
V
K
N
V
L
A
I
G
S
G
V
A
N
G
L
G
M
G
L
N
A
R
A
A
L
I
M
R
G
L
L
E
I
R
D
L
T
A
A
L
---
G
G
--
D
G
S
---
A
V
F
-
G
L
A
G
L
G
D
L
Q
L
T
C
S
S
E
L
S
R
N
F
T
-
V
G
K
-----
K
L
G
-
K
-
G
L
P
I
E
E
I
Q
R
------
A
V
A
E
G
V
A
T
A
D
P
L
M
R
L
A
K
Q
L
K
V
--
K
--
M
P
L
C
H
Q
I
Y
E
I
V
Y
K
K
K
N
P
R
D
A
L
A
D
L
L
S
C
G
L
Q
D
E
-------
7
PsiBlast_PDB
64.37
34%
-42
- C1 -
-
1N1E
1
GPDA_LEIME
A:
[20-350]
-----------
V
F
G
S
G
A
F
G
T
A
L
A
M
V
L
S
K
K
--
C
R
--------
E
-------
V
C
V
W
-------
H
M
N
E
E
E
-----
V
R
L
------
V
N
E
K
R
E
N
V
L
F
L
K
G
V
Q
L
A
S
N
I
T
F
T
S
D
V
E
K
A
Y
N
G
A
E
I
I
L
F
V
I
P
T
Q
F
L
R
G
F
F
E
K
SG
G
N
L
I
A
Y
A
K
E
-----
K
Q
V
P
V
L
V
C
T
K
G
I
E
--
R
S
T
L
--
K
F
P
A
E
I
I
G
E
F
L
P
S
P
L
-
L
S
---
V
L
A
G
P
S
F
A
I
E
V
A
T
G
V
F
T
C
V
S
I
A
---
S
A
D
I
N
---------
V
A
------
R
R
L
Q
R
I
M
S
TG
D
R
--
S
F
V
C
W
A
T
T
D
T
V
G
C
E
V
A
S
A
V
K
N
V
L
A
I
G
S
G
V
A
N
G
L
G
M
G
L
N
A
R
A
A
L
I
M
R
G
L
L
E
I
R
D
L
T
A
A
L
---
G
G
--
D
G
S
---
A
V
F
-
G
L
A
G
L
G
D
L
Q
L
T
C
S
S
E
L
S
R
N
F
T
-
V
G
K
-----
K
L
G
-
K
-
G
L
P
I
E
E
I
Q
R
T
S
--
K
-
A
V
A
E
G
V
A
T
A
D
P
L
M
R
L
A
K
Q
L
K
V
--
K
--
M
P
L
C
H
Q
I
Y
E
I
V
Y
K
K
K
N
P
R
D
A
L
A
D
L
L
S
C
G
L
Q
D
E
-------
6
PsiBlast_PDB
64.32
34%
-45
- C1 -
-
1M67
2
GPDA_LEIME
A:
[20-350]
-----------
V
F
G
S
G
A
F
G
T
A
L
A
M
V
L
S
K
K
--
C
R
--------
E
-------
V
C
V
W
-------
H
M
N
E
E
E
-----
V
R
L
------
V
N
E
K
R
E
N
V
L
F
L
K
G
V
Q
L
A
S
N
I
T
F
T
S
D
V
E
K
A
Y
N
G
A
E
I
I
L
F
V
I
P
T
Q
F
L
R
G
F
F
E
K
SG
G
N
L
I
A
Y
A
K
E
-----
K
Q
V
P
V
L
V
C
T
K
G
I
E
--
R
S
T
L
--
K
F
P
A
E
I
I
G
E
F
L
P
S
P
L
-
L
S
---
V
L
A
G
P
S
F
A
I
E
V
A
T
G
V
F
T
C
V
S
I
A
---
S
A
D
I
N
---------
V
A
------
R
R
L
Q
R
I
M
S
TG
D
R
--
S
F
V
C
W
A
T
T
D
T
V
G
C
E
V
A
S
A
V
K
N
V
L
A
I
G
S
G
V
A
N
G
L
G
M
G
L
N
A
R
A
A
L
I
M
R
G
L
L
E
I
R
D
L
T
A
A
L
---
G
G
--
D
G
S
---
A
V
F
-
G
L
A
G
L
G
D
L
Q
L
T
C
S
S
E
L
S
R
N
F
T
-
V
G
K
-----
K
L
G
-
K
-
G
L
P
I
E
E
I
Q
R
------
A
V
A
E
G
V
A
T
A
D
P
L
M
R
L
A
K
Q
L
K
V
--
K
--
M
P
L
C
H
Q
I
Y
E
I
V
Y
K
K
K
N
P
R
D
A
L
A
D
L
L
S
C
G
L
Q
D
E
-------
21
PsiBlast_CBE
64.27
34%
-40
- C1 -
-
1N1E
1
GPDA_LEIME
B:
[20-350]
-----------
V
F
G
S
G
A
F
G
T
A
L
A
M
V
L
S
K
K
--
C
R
--------
E
-------
V
C
V
W
-------
H
M
N
E
E
E
-----
V
R
L
------
V
N
E
K
R
E
N
V
L
F
L
K
G
V
Q
L
A
S
N
I
T
F
T
S
D
V
E
K
A
Y
N
G
A
E
I
I
L
F
V
I
P
T
Q
F
L
R
G
F
F
E
K
SGGNL
I
A
Y
A
K
E
-----
K
Q
V
P
V
L
V
C
T
K
G
I
E
--
R
S
T
L
--
K
F
P
A
E
I
I
G
E
F
L
P
S
P
L
-
L
S
---
V
L
A
G
P
S
F
A
I
E
V
A
T
G
V
F
T
C
V
S
I
A
---
S
A
D
I
N
---------
V
A
------
R
R
L
Q
R
I
M
S
TG
D
R
--
S
F
V
C
W
A
T
T
D
T
V
G
C
E
V
A
S
A
V
K
N
V
L
A
I
G
S
G
V
A
N
G
L
G
M
G
L
N
A
R
A
A
L
I
M
R
G
L
L
E
I
R
D
L
T
A
A
L
---
G
G
--
D
G
S
---
A
V
F
-
G
L
A
G
L
G
D
L
Q
L
T
C
S
S
E
L
S
R
N
F
T
-
V
G
K
-----
K
L
G
-
K
-
G
L
P
I
E
E
I
Q
R
T
S
--
K
-
A
V
A
E
G
V
A
T
A
D
P
L
M
R
L
A
K
Q
L
K
V
--
K
--
M
P
L
C
H
Q
I
Y
E
I
V
Y
K
K
K
N
P
R
D
A
L
A
D
L
L
S
C
G
L
Q
D
E
-------
5
PsiBlast_PDB
64.13
34%
-43
- C1 -
-
1M66
2
GPDA_LEIME
A:
[20-350]
-----------
V
F
G
S
G
A
F
G
T
A
L
A
M
V
L
S
K
K
--
C
R
--------
E
-------
V
C
V
W
-------
H
M
N
E
E
E
-----
V
R
L
------
V
N
E
K
R
E
N
V
L
F
L
K
G
V
Q
L
A
S
N
I
T
F
T
S
D
V
E
K
A
Y
N
G
A
E
I
I
L
F
V
I
P
T
Q
F
L
R
G
F
F
E
K
SG
G
N
L
I
A
Y
A
K
E
-----
K
Q
V
P
V
L
V
C
T
K
G
I
E
--
R
S
T
L
--
K
F
P
A
E
I
I
G
E
F
L
P
S
P
L
-
L
S
---
V
L
A
G
P
S
F
A
I
E
V
A
T
G
V
F
T
C
V
S
I
A
---
S
A
D
I
N
---------
V
A
------
R
R
L
Q
R
I
M
S
TG
D
R
--
S
F
V
C
W
A
T
T
D
T
V
G
C
E
V
A
S
A
V
K
N
V
L
A
I
G
S
G
V
A
N
G
L
G
M
G
L
N
A
R
A
A
L
I
M
R
G
L
L
E
I
R
D
L
T
A
A
L
---
G
G
--
D
G
S
---
A
V
F
-
G
L
A
G
L
G
D
L
Q
L
T
C
S
S
E
L
S
R
N
F
T
-
V
G
K
-----
K
L
G
-
K
-
G
L
P
I
E
E
I
Q
R
------
A
V
A
E
G
V
A
T
A
D
P
L
M
R
L
A
K
Q
L
K
V
--
K
--
M
P
L
C
H
Q
I
Y
E
I
V
Y
K
K
K
N
P
R
D
A
L
A
D
L
L
S
C
G
L
Q
D
E
-------
2
PsiBlast_PDB
63.92
34%
-42
- C1 -
-
1EVY
1
GPDA_LEIME
A:
[20-350]
-----------
V
F
G
S
G
A
F
G
T
A
L
A
M
V
L
S
K
K
--
C
R
--------
E
-------
V
C
V
W
-------
H
M
N
E
E
E
-----
V
R
L
------
V
N
E
K
R
E
N
V
L
F
L
K
G
V
Q
L
A
S
N
I
T
F
T
S
D
V
E
K
A
Y
N
G
A
E
I
I
L
F
V
I
P
T
Q
F
L
R
G
F
F
E
K
SG
G
N
L
I
A
Y
A
K
E
-----
K
Q
V
P
V
L
V
C
T
K
G
I
E
--
R
S
T
L
--
K
F
P
A
E
I
I
G
E
F
L
P
S
P
L
-
L
S
---
V
L
A
G
P
S
F
A
I
E
V
A
T
G
V
F
T
C
V
S
I
A
---
S
A
D
I
N
---------
V
A
------
R
R
L
Q
R
I
M
S
TG
D
R
--
S
F
V
C
W
A
T
T
D
T
V
G
C
E
V
A
S
A
V
K
N
V
L
A
I
G
S
G
V
A
N
G
L
G
M
G
L
N
A
R
A
A
L
I
M
R
G
L
L
E
I
R
D
L
T
A
A
L
---
G
G
--
D
G
S
---
A
V
F
-
G
L
A
G
L
G
D
L
Q
L
T
C
S
S
E
L
S
R
N
F
T
-
V
G
K
-----
K
L
G
-
K
-
G
L
P
I
E
E
I
Q
R
------
A
V
A
E
G
V
A
T
A
D
P
L
M
R
L
A
K
Q
L
K
V
--
K
--
M
P
L
C
H
Q
I
Y
E
I
V
Y
K
K
K
N
P
R
D
A
L
A
D
L
L
S
C
G
L
Q
D
E
-------
3
PsiBlast_PDB
63.81
34%
-43
- C1 -
-
1EVZ
2
GPDA_LEIME
A:
[20-350]
-----------
V
F
G
S
G
A
F
G
T
A
L
A
M
V
L
S
K
K
--
C
R
--------
E
-------
V
C
V
W
-------
H
M
N
E
E
E
-----
V
R
L
------
V
N
E
K
R
E
N
V
L
F
L
K
G
V
Q
L
A
S
N
I
T
F
T
S
D
V
E
K
A
Y
N
G
A
E
I
I
L
F
V
I
P
T
Q
F
L
R
G
F
F
E
K
SG
G
N
L
I
A
Y
A
K
E
-----
K
Q
V
P
V
L
V
C
T
K
G
I
E
--
R
S
T
L
--
K
F
P
A
E
I
I
G
E
F
L
P
S
P
L
-
L
S
---
V
L
A
G
P
S
F
A
I
E
V
A
T
G
V
F
T
C
V
S
I
A
---
S
A
D
I
N
---------
V
A
------
R
R
L
Q
R
I
M
S
TG
D
R
--
S
F
V
C
W
A
T
T
D
T
V
G
C
E
V
A
S
A
V
K
N
V
L
A
I
G
S
G
V
A
N
G
L
G
M
G
L
N
A
R
A
A
L
I
M
R
G
L
L
E
I
R
D
L
T
A
A
L
---
G
G
--
D
G
S
---
A
V
F
-
G
L
A
G
L
G
D
L
Q
L
T
C
S
S
E
L
S
R
N
F
T
-
V
G
K
-----
K
L
G
-
K
-
G
L
P
I
E
E
I
Q
R
------
A
V
A
E
G
V
A
T
A
D
P
L
M
R
L
A
K
Q
L
K
V
--
K
--
M
P
L
C
H
Q
I
Y
E
I
V
Y
K
K
K
N
P
R
D
A
L
A
D
L
L
S
C
G
L
Q
D
E
-------
11
PsiBlast_PDB
63.57
30%
-19
- C1 -
-
1WPQ
2
GPDA_HUMAN
A:
[2-345]
-----
A
S
K
K
V
C
I
V
G
S
G
N
W
G
S
A
I
A
K
I
V
G
G
N
--
A
A
--------
Q
LAQFDP
R
V
T
M
W
V
FEEDIG
G
K
K
L
T
E
-----
I
--------
I
N
T
Q
H
E
N
V
K
Y
L
P
G
H
K
L
P
P
N
V
V
A
V
P
D
V
V
Q
A
A
E
D
A
D
I
L
I
F
V
V
P
H
Q
F
I
G
K
I
C
D
Q
-----
L
K
G
H
L
K
-----
A
N
P
T
G
I
S
L
I
K
G
V
D
E
G
P
N
G
L
--
K
L
I
S
----
E
V
I
G
E
R
L
-
G
I
P
M
S
V
L
M
G
A
N
I
A
S
E
V
A
D
E
K
F
C
E
T
T
I
G
---
C
K
D
P
A
---------
Q
G
------
Q
L
L
K
E
L
M
Q
--
T
P
--
N
F
R
I
T
V
V
Q
E
V
D
T
V
E
I
C
G
A
L
K
N
V
V
A
V
G
A
G
F
C
D
G
L
G
F
G
D
N
T
K
A
A
V
I
R
L
G
L
M
E
M
I
A
F
A
K
L
F
---
C
S
--
G
P
V
S
S
A
T
F
L
-
E
S
C
G
V
A
D
L
I
T
--
T
C
Y
G
G
R
N
R
K
-
V
A
E
-----
A
F
A
-
R
T
G
K
S
I
E
Q
L
E
K
E
L
LN
G
-
Q
K
L
Q
G
P
E
T
A
R
E
L
Y
S
I
L
Q
H
K
G
L
--
V
DK
F
P
L
F
M
A
V
Y
K
V
C
Y
E
G
Q
P
V
G
E
F
I
H
C
L
Q
N
H
------------
8
PsiBlast_PDB
63.46
34%
-40
- C1 -
-
1N1G
3
GPDA_LEIME
A:
[20-350]
-----------
V
F
G
S
G
A
F
G
T
A
L
A
M
V
L
S
K
K
--
C
R
--------
E
-------
V
C
V
W
-------
H
M
N
E
E
E
-----
V
R
L
------
V
N
E
K
R
E
N
V
L
F
L
K
G
V
Q
L
A
S
N
I
T
F
T
S
D
V
E
K
A
Y
N
G
A
E
I
I
L
F
V
I
P
T
Q
F
L
R
G
F
F
E
K
SG
G
N
L
I
A
Y
A
K
E
-----
K
Q
V
P
V
L
V
C
T
K
G
I
E
--
R
S
T
L
--
K
F
P
A
E
I
I
G
E
F
L
P
S
P
L
-
L
S
---
V
L
A
G
P
S
F
A
I
E
V
A
T
G
V
F
T
C
V
S
I
A
---
S
A
D
I
N
---------
V
A
------
R
R
L
Q
R
I
M
S
TG
D
R
--
S
F
V
C
W
A
T
T
D
T
V
G
C
E
V
A
S
A
V
K
N
V
L
A
I
G
S
G
V
A
N
G
L
G
M
G
L
N
A
R
A
A
L
I
M
R
G
L
L
E
I
R
D
L
T
A
A
L
---
G
G
--
D
G
S
---
A
V
F
-
G
L
A
G
L
G
D
L
Q
L
T
C
S
S
E
L
S
R
N
F
T
-
V
G
K
-----
K
L
G
-
K
-
G
L
P
I
E
E
I
Q
R
------
A
V
A
E
G
V
A
T
A
D
P
L
M
R
L
A
K
Q
L
K
V
--
K
--
M
P
L
C
H
Q
I
Y
E
I
V
Y
K
K
K
N
P
R
D
A
L
A
D
L
L
S
C
G
L
Q
D
E
-------
10
PsiBlast_PDB
63.45
30%
-22
- C1 -
-
1X0X
1
GPDA_HUMAN
A:
[6-350]
----
M
A
S
K
K
V
C
I
V
G
S
G
N
W
G
S
A
I
A
K
I
V
G
G
N
--
A
A
--------
Q
LAQFDPR
V
T
M
W
V
F
E
E
D
I
G
G
K
K
L
T
E
-----
I
--------
I
N
T
Q
H
E
N
V
K
Y
L
P
G
H
K
L
P
P
N
V
V
A
V
P
D
V
V
Q
A
A
E
D
A
D
I
L
I
F
V
V
P
H
Q
F
I
G
K
I
C
D
Q
-----
L
K
G
H
L
K
-----
A
N
A
T
G
I
S
L
I
K
G
V
D
E
G
P
N
G
L
--
K
L
I
S
----
E
V
I
G
E
R
L
-
G
I
P
M
S
V
L
M
G
A
N
I
A
S
E
V
A
D
E
K
F
C
E
T
T
I
G
---
C
K
D
P
A
---------
Q
G
------
Q
L
L
K
E
L
M
Q
--
T
P
--
N
F
R
I
T
V
V
Q
E
V
D
T
V
E
I
C
G
A
L
K
N
V
V
A
V
G
A
G
F
C
D
G
L
G
F
G
D
N
T
K
A
A
V
I
R
L
G
L
M
E
M
I
A
F
A
K
L
F
---
C
S
--
G
P
V
S
S
A
T
F
L
-
E
S
C
G
V
A
D
L
I
T
--
T
C
Y
G
G
R
N
R
K
-
V
A
E
-----
A
F
A
-
R
T
G
K
S
I
E
Q
L
E
K
E
L
LN
G
-
Q
K
L
Q
G
P
E
T
A
R
E
L
Y
S
I
L
Q
H
K
G
L
--
V
DK
F
P
L
F
M
A
V
Y
K
V
C
Y
E
G
Q
P
V
G
E
F
I
H
C
L
Q
N
H
------------
29
Fugue
63.30
34%
-2
- C1 -
-
1EVY
1
GPDA_LEIME
A:
[9-357]
KD
E
L
L
Y
L
N
K
A
V
V
F
G
S
G
A
F
G
T
A
L
A
M
V
L
S
K
K
--
C
R
--------
E
-------
V
C
V
W
-------
H
M
N
E
E
E
-----
V
R
L
------
V
N
E
K
R
E
N
V
L
F
L
K
G
V
Q
L
A
S
N
I
T
F
T
S
D
V
E
K
A
Y
N
G
A
E
I
I
L
F
V
I
P
T
Q
F
L
R
G
F
F
E
K
SG
G
N
L
I
A
Y
A
K
E
-----
K
Q
V
P
V
L
V
C
T
K
G
I
E
--
R
S
T
L
--
K
F
P
A
E
I
I
G
E
F
L
P
S
P
L
----
L
S
V
L
A
G
P
S
F
A
I
E
V
A
T
G
V
F
T
C
V
S
I
A
---
S
A
D
I
N
---------
V
A
------
R
R
L
Q
R
I
M
S
TG
D
R
--
S
F
V
C
W
A
T
T
D
T
V
G
C
E
V
A
S
A
V
K
N
V
L
A
I
G
S
G
V
A
N
G
L
G
M
G
L
N
A
R
A
A
L
I
M
R
G
L
L
E
I
R
D
L
T
A
A
L
---
G
G
--
D
G
S
---
A
V
F
-
G
L
A
G
L
G
D
L
Q
L
T
C
S
S
E
L
S
R
N
F
T
-
V
G
K
-----
K
L
G
-
K
-
G
L
P
---
I
E
E
I
Q
--
R
-
A
V
A
E
G
V
A
T
A
D
P
L
M
R
L
A
K
Q
L
K
V
--
K
--
M
P
L
C
H
Q
I
Y
E
I
V
Y
K
K
K
N
P
R
D
A
L
A
D
L
L
S
C
G
L
Q
D
E
G
L
P
P
LFK