@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : spr1909: (2018-01-22 )
MQNQLNELKRKMLEFFQQKQKNKKSARPGKKGSSTKKSKTLDKSAIFPAILLSIKALFNLLFVLGFLGGMLGAGIALGYGVALFDKVRVPQTEELVNQVKDISSISEITYSDGTVIASIESDLLRTSISSEQISENLKKAIIATEDEHFKEHKGVVPKAVIRATLGKFVGLGSSSGGSTLTQQLIKQQVVGDAPTLARKAAEIVDALALERAMNKDEILTTYLNVAPFGRNNKGQNIAGARQAAEGIFGVDASQLTVPQAAFLAGLPQSPITYSPYENTGELKSDEDLEIGLRRAKAVLYSMYRTGALSKDEYSQYKDYDLKQDFLPSGTVTGISRDYLYFTTLAEAQERMYDYLAQRDNVSAKELKNEATQKFYRDLAAKEIENGGYKITTTIDQKIHSAMQSAVADYGYLLDDGTGRVEVGNVLMDNQTGAILGFVGGRNYQENQNNHAFDTKRSPASTTKPLLAYGIAIDQGLMGSETILSNYPTNFANGNPIMYANSKGTGMMTLGEALNYSWNIPAYWTYRMLRENGVDVKGYMEKMGYEIPEYGIESLPMGGGIEVTVAQHTNGYQTLANNGVYHQKHVISKIEAADGRVVYEYQDKPVQVYSKATATIMQGLLREVLSSRVTTTFKSNLTSLNPTLANADWIGKTGTTNQDENMWLMLSTPRLTLGGWIGHDDNHSLSRRAGYSNNSNYMAHLVNAIQQASPSIWGNERFALDPSVVKSEVLKSTGQKPGKVSVEGKEVEVTGSTVTSYWANKSGAPATSYRFAIGGSDADYQNAWSSIVGSLPTPSSSSSSSSSSSDSSNSSTTRPSSSRARR
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120-........130.......140.......150.......160.......170.......180.......190.......200.....---..210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320------------------.........330-------........340..-----.....350.......360--------.......370.......380.......390.......400.......410---..----------------------------------------------------------------------------------------------.--...---------------------------------.420.......430.......440...-.-..-.450.......460......------.470..-.-----.-...480..--...-.-..490-----........500.------.--.....510.......520...---...---.530...-.-...--.540.--....-.-.550....--....-560-........570.......580.......590.......600------------------------------.......610.......620....-------...630.......640.......650..--------------.--------------.--------------...660.......670.......680...-----.--.--..690.......700.......710.......720.......730.......740.......750.......760.......770.......780.......790.......800.......810.......820
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MQ
N
Q
L
N
E
L
K
R
K
M
L
E
F
F
Q
Q
K
QKNKKSARPGKKGSSTKKSKTL
D
K
S
A
I
F
P
A
I
L
L
S
I
K
A
L
F
N
L
L
F
V
L
G
F
L
G
G
M
L
G
A
G
I
A
L
G
Y
G
V
A
L
F
DKVRVP
Q
T
E
E
L
V
N
Q
V
K
D
I
S
S
I
S
E
I
TYSD
G
T
V
I
A
S
I
E
S
--
D
L
L
RTSI
S
S
E
Q
I
S
E
N
L
K
K
A
I
IAT
E
D
E
H
F
K
E
H
KGV
V
P
K
A
V
I
R
A
T
L
G
K
F
VGLGSSSG
G
S
T
L
T
Q
Q
L
I
K
Q
Q
VVGDA
P
T
L
A
R
K
A
A
E
I
V
D
A
L
---
A
L
E
R
AM
N
K
D
E
I
L
T
T
Y
LNVAPFGRNNKGQ
N
I
A
G
A
R
Q
A
AEGIFGVDASQLTV
P
Q
A
A
F
L
AGLPQSPITYSPYENTGELKSD
E
D
L
E
I
G
L
R
R
A
K
A
V
L
Y
S
M
Y
RTGAL
S
K
D
E
Y
S
QYKDYD--------------------
L
K
Q
DFLPSGTV--------TGISR
D
Y
L
Y
F
T
T
L
-----
A
E
A
Q
E
R
M
Y
D
Y
L
A
QRDNV
S
--------
A
K
E
L
K
N
E
A
T
Q
K
F
Y
R
D
L
A
A
K
E
I
ENG
G
Y
K
I
T
T
T
I
D
Q
K
I
H
S
A
M
Q
S
A
V
A
DY
G
Y
L
---LD----------------------------------------------------------------------------------------------D--GTG---------------------------------
R
V
E
V
G
N
V
L
MDNQT
G
A
I
L
G
F
VGGRNYQE-N-QN-NHAFDTKRSPASTTK
P
L
L
A
Y
------
G
I
AIDQ-G-----L-MGS
E
-
T
I
L
--SNY-P-TNF-A-----NGN
P
I
M
Y
ANSKG------T--
G
M
M
T
L
G
E
ALNYSWNI
P
A
Y
W
T
Y
---
R
M
L
---
R
EN-GV
D
-
V
-
K
G
Y
--
M
E
K
MG--YEI
P
-
E
-YG-IESLP--MGG
G
-
I
-
E
-
V
T
V
AQHTNG
Y
Q
T
LANNGV
Y
H
Q
K
H
V
I
S
K
IEAAD
G
R
V
V
Y
E
YQD------------------------------K
P
V
Q
V
Y
S
K
A
T
A
T
I
M
Q
G
L
L
R
E
V
L
S
S
-------
R
V
T
T
T
F
KSNLTSLNPTLANADWIGKTGT--------------T--------------N--------------QDE
N
M
W
L
M
LSTP
R
L
T
L
G
G
W
IGHDDNH
S
L
S
-----
R
--R--AGYSNN
S
N
Y
M
A
H
L
V
N
A
I
Q
Q
ASPSIWGNERFAL
D
P
S
V
V
K
S
E
V
L
K
STGQKP
G
K
V
S
V
EG
K
E
V
E
V
TG
S
T
V
T
S
YWANKSGAPAT
S
Y
R
F
A
IGGSD
A
D
Y
Q
N
A
W
S
S
I
VGSLPTPSSSSSSSSSSSDSSNSSTTRPSSSRARR
47
Fugue
89.90
99%
-72
- C1 -
-
2BG1
-
?
A:
[8-491]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
T
Y
D
Y
L
Y
F
T
T
L
-----
A
E
A
Q
E
R
M
Y
D
Y
L
A
Q
R
D
N
V
S
--------
A
K
E
L
K
N
E
A
T
Q
K
F
Y
R
D
L
A
A
K
E
I
E
N
G
G
Y
K
I
T
T
T
I
D
Q
K
I
H
S
A
M
Q
S
A
V
A
D
Y
G
Y
L
---
L
D
----------------------------------------------------------------------------------------------
D
--
G
T
G
---------------------------------
R
V
E
V
G
N
V
L
M
D
N
Q
T
G
A
I
L
G
F
V
G
G
R
N
Y
Q
E
-
N
-
Q
N
-
N
H
A
F
D
T
K
R
S
P
A
S
T
T
K
P
L
L
A
Y
------
G
I
A
I
D
Q
-
G
-----
L
-
M
G
S
E
-
T
I
L
--
S
N
Y
-
P
-
T
N
F
-
A
-----
N
G
N
P
I
M
Y
A
N
S
K
G
------
T
--
G
M
M
T
L
G
E
A
L
N
Y
S
W
N
I
P
A
Y
W
T
Y
---
R
M
L
---
R
E
N
-
G
V
D
-
V
-
K
G
Y
--
M
E
K
M
G
--
Y
E
I
P
-
E
-
Y
G
-
I
E
S
L
P
--
M
G
G
G
-
I
-
E
-
V
T
V
A
Q
H
T
N
G
Y
Q
T
L
A
N
N
G
V
Y
H
Q
K
H
V
I
S
K
I
E
A
A
D
G
R
V
V
Y
E
Y
Q
D
------------------------------
K
P
V
Q
V
Y
S
K
A
T
A
T
I
M
Q
G
L
L
R
E
V
L
S
S
-------
R
V
T
T
T
F
K
S
N
L
T
S
L
N
P
T
L
A
N
A
D
W
I
G
K
T
G
T
--------------
T
--------------
N
--------------
Q
D
E
N
M
W
L
M
L
S
T
P
R
L
T
L
G
G
W
I
G
H
D
D
N
H
S
L
S
-----
Q
--
Q
--
A
G
Y
S
N
N
S
N
Y
M
A
H
L
V
N
A
I
Q
Q
A
S
P
S
I
W
G
N
E
R
F
A
L
D
P
S
V
V
K
S
E
V
L
K
S
T
G
Q
K
P
G
K
V
S
V
E
G
K
E
V
E
V
T
G
S
T
V
T
S
Y
W
A
N
K
S
G
A
P
A
T
S
Y
R
F
A
I
G
G
S
D
A
D
Y
Q
N
A
W
S
S
I
V
G
---------------------------------
2
PsiBlast_PDB
89.80
97%
-76
- C1 -
-
2JCH
2
?
A:
[42-718]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
T
V
--------
I
A
-
S
I
D
Y
L
Y
F
T
T
L
-----
A
E
A
Q
E
R
M
Y
D
Y
L
A
Q
R
D
N
V
S
--------
A
------
A
T
Q
K
F
Y
R
D
L
A
A
K
E
I
E
N
G
G
Y
K
I
T
T
T
I
D
Q
K
I
H
S
A
M
Q
S
A
V
A
D
Y
G
Y
L
---
L
D
----------------------------------------------------------------------------------------------
D
--
G
T
G
---------------------------------
R
V
E
V
G
N
V
L
M
D
N
Q
T
G
A
I
L
G
F
V
G
G
R
N
Y
Q
E
-
N
-
Q
N
-
N
H
A
F
D
T
K
R
S
P
A
S
T
T
K
P
L
L
A
Y
------
G
I
A
I
D
Q
-
G
-----
L
-
M
G
S
E
-
T
I
L
--
S
N
Y
-
P
-
T
N
F
-
A
-----
N
G
N
P
I
M
Y
A
N
S
K
G
------
T
--
G
M
M
T
L
G
E
A
L
N
Y
S
W
N
I
P
A
Y
W
T
Y
---
R
M
L
---
R
E
N
-
G
V
D
-
V
-
K
G
Y
--
M
E
K
M
G
--
Y
E
I
P
-
E
-
Y
G
-
I
E
S
L
P
--
M
G
G
G
-
I
-
E
-
V
T
V
A
Q
H
T
N
G
Y
Q
T
L
A
N
N
G
V
Y
H
Q
K
H
V
I
S
K
I
E
A
A
D
G
R
V
V
Y
E
Y
Q
D
------------------------------
K
P
V
Q
V
Y
S
K
A
T
A
T
I
M
Q
G
L
L
R
E
V
L
S
S
-------
R
V
T
T
T
F
K
S
N
L
T
S
L
N
P
T
L
A
N
A
D
W
I
G
K
T
G
T
--------------
T
--------------
N
--------------
Q
D
E
N
M
W
L
M
L
S
T
P
R
L
T
L
G
G
W
I
G
H
D
D
N
H
S
L
S
-----
Q
--
Q
--
A
G
Y
S
N
N
S
N
Y
M
A
H
L
V
N
A
I
Q
Q
A
S
P
S
I
W
G
N
E
R
F
A
L
D
P
S
V
V
K
S
E
V
L
K
S
T
G
Q
K
P
G
K
V
S
V
E
G
K
E
V
E
V
T
G
S
T
V
T
S
Y
W
A
N
K
S
G
A
P
A
T
S
Y
R
F
A
I
G
G
S
D
A
D
Y
Q
N
A
W
S
S
I
V
G
S
--------------------------------
1
PsiBlast_PDB
88.22
100%
-68
- C1 -
-
2FFF
-
?
B:
[1-453]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Y
L
Y
F
T
T
L
-----
A
E
A
Q
E
R
M
Y
D
Y
L
A
Q
R
D
N
V
S
--------
A
K
E
L
K
N
E
A
T
Q
K
F
Y
R
D
L
A
A
K
E
I
E
N
G
G
Y
K
I
T
T
T
I
D
Q
K
I
H
S
A
M
Q
S
A
V
A
D
Y
G
Y
L
---
L
D
----------------------------------------------------------------------------------------------
D
--
G
T
G
---------------------------------
R
V
E
V
G
N
V
L
M
D
N
Q
T
G
A
I
L
G
F
V
G
G
R
N
Y
Q
E
-
N
-
Q
N
-
N
H
A
F
D
T
K
R
S
P
A
S
T
T
K
P
L
L
A
Y
------
G
I
A
I
D
Q
-
G
-----
L
-
M
G
S
E
-
T
I
L
--
S
N
Y
-
P
-
T
N
F
-
A
-----
N
G
N
P
I
M
Y
A
N
S
K
G
------
T
--
G
M
M
T
L
G
E
A
L
N
Y
S
W
N
I
P
A
Y
W
T
Y
---
R
M
L
---
R
E
N
-
G
V
D
-
V
-
K
G
Y
--
M
E
K
M
G
--
Y
E
I
P
-
E
-
Y
G
-
I
E
S
L
P
--
M
G
G
G
-
I
-
E
-
V
T
V
A
Q
H
T
N
G
Y
Q
T
L
A
N
N
G
V
Y
H
Q
K
H
V
I
S
K
I
E
A
A
D
G
R
V
V
Y
E
Y
Q
D
------------------------------
K
P
V
Q
V
Y
S
K
A
T
A
T
I
M
Q
G
L
L
R
E
V
L
S
S
-------
R
V
T
T
T
F
K
S
N
L
T
S
L
N
P
T
L
A
N
A
D
W
I
G
K
T
G
T
--------------
T
--------------
N
--------------
Q
D
E
N
M
W
L
M
L
S
T
P
R
L
T
L
G
G
W
I
G
H
D
D
N
H
S
L
S
-----
R
--
R
--
A
G
Y
S
N
N
S
N
Y
M
A
H
L
V
N
A
I
Q
Q
A
S
P
S
I
W
G
N
E
R
F
A
L
D
P
S
V
V
K
S
E
V
L
K
S
T
G
Q
K
P
G
K
V
S
V
E
G
K
E
V
E
V
T
G
S
T
V
T
S
Y
W
A
N
K
S
G
A
P
A
T
S
Y
R
F
A
I
G
G
S
D
A
D
Y
Q
N
A
W
S
S
I
V
G
S
--------------------------------
30
HHSearch
75.08
98%
7
- C1 -
-
2Y2M
1
?
A:
[39-493]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
Y
L
Y
F
T
T
L
-----
A
E
A
Q
E
R
M
Y
D
Y
L
A
Q
R
D
N
V
S
--------
A
K
E
L
K
N
E
A
T
Q
K
F
Y
R
D
L
A
A
K
E
I
E
N
G
G
Y
K
I
T
T
T
I
D
Q
K
I
H
S
A
M
Q
S
A
V
A
D
Y
G
Y
L
---
L
D
----------------------------------------------------------------------------------------------
D
--
G
T
G
---------------------------------
R
V
E
V
G
N
V
L
M
D
N
Q
T
G
A
I
L
G
F
V
G
G
R
N
Y
Q
E
-
N
-
Q
N
-
N
H
A
F
D
T
K
R
S
P
A
S
T
T
K
P
L
L
A
Y
------
G
I
A
I
D
Q
-
G
-----
L
-
M
G
S
E
-
T
I
L
--
S
N
Y
-
P
-
T
N
F
-
A
-----
N
G
N
P
I
M
Y
A
N
S
K
G
------
T
--
G
M
M
T
L
G
E
A
L
N
Y
S
W
N
I
P
A
Y
W
T
Y
---
R
M
L
R
E
-
N
G
V
-
D
---
V
-
K
G
Y
--
M
E
K
M
G
--
Y
E
I
P
-
E
-
Y
G
-
I
E
S
L
P
--
M
G
G
G
-
I
-
E
-
V
T
V
A
Q
H
T
N
G
Y
Q
T
L
A
N
N
G
V
Y
H
Q
K
H
V
I
S
K
I
E
A
A
D
G
R
V
V
Y
E
Y
Q
D
------------------------------
K
P
V
Q
V
Y
S
K
A
T
A
T
I
M
Q
G
L
L
R
E
V
L
S
S
-------
R
V
T
T
T
F
K
S
N
L
T
S
L
N
P
T
L
A
N
A
D
W
I
G
K
T
G
T
--------------
T
--------------
G
--------------
Q
D
E
N
M
W
L
M
L
S
T
P
R
L
T
L
G
G
W
I
G
H
D
D
N
H
S
L
S
-----
Q
--
Q
--
A
G
Y
S
N
N
S
N
Y
M
A
H
L
V
N
A
I
Q
Q
A
S
P
S
I
W
G
N
E
R
F
A
L
D
P
S
V
V
K
S
E
V
L
K
S
T
G
Q
K
P
G
K
V
S
V
E
G
K
E
V
E
V
T
G
S
T
V
T
S
Y
W
A
N
K
S
G
A
P
A
T
S
Y
R
F
A
I
G
G
S
D
A
D
Y
Q
N
A
W
S
S
I
V
G
S
L
-------------------------------
31
HHSearch
72.52
99%
17
- C1 -
-
2FFF
-
?
B:
[1-453]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Y
L
Y
F
T
T
L
-----
A
E
A
Q
E
R
M
Y
D
Y
L
A
Q
R
D
N
V
S
--------
A
K
E
L
K
N
E
A
T
Q
K
F
Y
R
D
L
A
A
K
E
I
E
N
G
G
Y
K
I
T
T
T
I
D
Q
K
I
H
S
A
M
Q
S
A
V
A
D
Y
G
Y
L
---
L
D
----------------------------------------------------------------------------------------------
D
--
G
T
G
---------------------------------
R
V
E
V
G
N
V
L
M
D
N
Q
T
G
A
I
L
G
F
V
G
G
R
N
Y
Q
E
-
N
-
Q
N
-
N
H
A
F
D
T
K
R
S
P
A
S
T
T
K
P
L
L
A
Y
------
G
I
A
I
D
Q
-
G
-----
L
-
M
G
S
E
-
T
I
L
--
S
N
Y
-
P
-
T
N
F
-
A
-----
N
G
N
P
I
M
Y
A
N
S
K
G
------
T
--
G
M
M
T
L
G
E
A
L
N
Y
S
W
N
I
P
A
Y
W
T
Y
R
M
L
R
E
----
N
G
V
-
D
---
V
-
K
G
Y
--
M
E
K
M
G
--
Y
E
I
P
-
E
-
Y
G
-
I
E
S
L
P
--
M
G
G
G
-
I
-
E
-
V
T
V
A
Q
H
T
N
G
Y
Q
T
L
A
N
N
G
V
Y
H
Q
K
H
V
I
S
K
I
E
A
A
D
G
R
V
V
Y
E
Y
Q
D
------------------------------
K
P
V
Q
V
Y
S
K
A
T
A
T
I
M
Q
G
L
L
R
E
V
L
S
S
-------
R
V
T
T
T
F
K
S
N
L
T
S
L
N
P
T
L
A
N
A
D
W
I
G
K
T
G
T
--------------
T
--------------
N
--------------
Q
D
E
N
M
W
L
M
L
S
T
P
R
L
T
L
G
G
W
I
G
H
D
D
N
H
S
L
S
-----
R
--
R
--
A
G
Y
S
N
N
S
N
Y
M
A
H
L
V
N
A
I
Q
Q
A
S
P
S
I
W
G
N
E
R
F
A
L
D
P
S
V
V
K
S
E
V
L
K
S
T
G
Q
K
P
G
K
V
S
V
E
G
K
E
V
E
V
T
G
S
T
V
T
S
Y
W
A
N
K
S
G
A
P
A
T
S
Y
R
F
A
I
G
G
S
D
A
D
Y
Q
N
A
W
S
S
I
V
G
S
--------------------------------
25
HHSearch
58.98
26%
-17
- C1 -
-
5U2G
1
PBPA_HAEIN
A:
[18-803]
-----------------------------------------------------------------------------------------------------
L
Q
Q
P
M
Q
I
Y
T
A
D
G
K
L
I
G
E
V
G
---
E
Q
R
R
I
P
V
K
L
A
D
V
P
Q
R
L
I
D
A
F
L
A
T
E
D
S
R
--------------------------------------------------------------------
N
K
Q
E
I
L
E
L
Y
L
N
K
I
F
L
G
Y
R
S
-----
Y
G
V
A
A
A
A
Q
T
Y
F
G
K
S
L
N
E
L
T
L
S
E
M
A
I
I
A
G
L
P
K
A
P
S
T
M
N
P
L
Y
---------
S
L
K
R
S
E
E
R
R
N
V
V
L
S
R
M
L
D
E
K
Y
I
S
K
E
E
Y
D
A
A
L
K
E
P
--------------------
I
V
A
S
------
K
--------
F
E
F
R
A
D
Y
V
T
E
M
V
R
-----
Q
E
--------
M
V
R
R
F
G
---------------------------
E
E
N
A
Y
T
S
G
Y
K
V
F
T
T
V
L
S
K
D
Q
A
E
A
Q
K
A
V
R
N
N
L
I
D
---
Y
D
M
R
H
GYR
G
G
A
P
LWQKNEAAWD
N
D
R
I
V
G
F
L
R
K
LPDSEP
F
I
P
A
A
V
IGIVKG
G
A
D
I
L
L
ASG
E
K
M
T
LSTNAMRWTGRSNPVKVG
E
Q
I
W
I
H
Q
R
ANG
E
W
Q
L
G
--
Q
I
P
---------------------------------
A
A
N
S
A
L
V
S
L
N
S
D
N
G
A
I
E
A
V
V
G
G
F
S
Y
E
Q
-
S
-
K
F
-
N
R
A
T
Q
S
L
V
Q
V
G
S
S
I
K
P
F
-
I
Y
------
A
A
A
L
E
K
-
G
-----
L
--
T
L
S
-
S
V
L
--
Q
D
S
-
P
-
I
S
I
-
Q
K
PGQ
K
M
W
Q
P
K
N
S
P
D
R
-
Y
------
D
--
G
P
M
R
L
R
V
G
L
G
Q
S
K
N
I
I
A
I
R
A
I
---
Q
T
----
A
G
I
-
D
F
--
T
-
A
E
F
--
L
Q
R
F
G
--
F
K
R
D
-
Q
Y
F
A
-
S
E
A
L
A
--
L
G
A
A
---
S
-
F
T
P
L
E
M
A
R
A
Y
A
V
F
D
N
G
G
F
L
I
E
P
Y
I
I
E
K
I
Q
D
N
T
G
K
D
L
F
I
A
N
P
KIACIECNDIPVIYGETKDKINGFAS
S
K
I
E
Y
A
P
R
V
I
S
G
E
L
A
F
L
I
R
S
A
L
N
T
A
I
Y
G
EQGLDWK
G
T
S
W
R
I
-------
A
Q
S
I
K
R
S
D
I
G
G
K
T
G
T
--------------
T
--------------
N
--------------
S
S
K
V
A
W
Y
A
G
F
G
A
N
L
V
T
T
T
Y
V
G
F
D
D
N
K
R
V
L
GR---
G
--
E
--
A
G
A
K
T
A
M
P
A
W
I
T
Y
M
K
T
A
L
S
D
K
P
----
E
R
K
L
S
L
P
P
K
I
V
E
K
N
I
D
T
L
T
G
L
L
S
P
N
G
G
--
R
K
E
Y
F
I
A
G
T
E
P
T
R
T
-----------------------------------------------------------------
4
PsiBlast_PDB
56.37
24%
-17
- C1 -
-
2OLV
1
?
A:
[17-565]
---------------------------------------------------------------------------------------------------------
A
K
I
Y
D
K
N
G
E
L
V
K
T
L
D
N
--
G
Q
R
H
E
H
V
N
L
K
D
V
P
K
S
M
K
D
A
V
L
A
T
E
D
N
R
F
Y
E
H
G
A
L
D
Y
K
R
L
F
G
A
I
G
K
---------
G
A
S
T
L
T
Q
Q
V
V
K
D
A
F
L
S
Q
H
K
S
I
G
R
K
A
Q
E
A
Y
L
S
Y
---
R
L
E
Q
E
Y
S
K
D
D
I
F
Q
V
Y
L
N
K
I
Y
Y
-----
S
D
G
V
T
G
I
K
A
A
A
K
Y
Y
F
N
K
D
L
K
D
L
N
L
A
E
E
A
Y
L
A
G
L
P
Q
V
P
N
N
Y
N
I
Y
D
H
P
---
K
A
A
E
D
------
R
K
N
T
V
L
Y
L
M
H
Y
H
K
R
I
T
D
K
Q
W
E
D
A
K
K
I
D
--------------------
L
K
A
N
L
----------------
V
N
R
T
P
E
E
R
Q
N
I
-----
D
T
N
Q
D
S
E
Y
N
S
Y
V
---
N
F
V
--------
K
S
E
L
M
N
---
N
K
A
F
K
D
E
N
L
G
N
V
L
Q
S
G
I
K
I
Y
T
N
M
D
K
D
V
Q
K
T
L
Q
N
D
V
D
N
G
S
F
Y
---
K
N
----------------------------------------------------------------------------------------------
K
--
D
Q
------------------------------------
Q
V
G
A
T
I
L
D
S
K
T
G
G
L
V
A
I
S
G
G
R
D
F
K
D
-
V
-
V
N
-
R
N
Q
A
T
D
P
H
P
T
G
S
S
L
K
P
F
L
A
Y
------
G
P
A
I
E
N
-
M
-----
K
-
W
A
T
N
-
H
A
I
--
Q
D
E
-
S
-
S
Y
Q
-
V
-----
D
G
S
T
F
R
N
Y
D
T
K
S
------
H
--
G
T
V
S
I
Y
D
A
L
R
Q
S
F
N
I
P
A
L
K
A
W
---
Q
S
V
---
K
Q
N
A
G
N
D
-
A
P
K
K
F
--
A
A
K
L
G
LN
Y
E
-
G
-
D
-
I
G
-
P
S
E
V
L
--
G
G
S
A
-
S
-
E
-
F
S
P
T
Q
L
A
S
A
F
A
A
I
A
N
G
G
T
Y
N
N
A
H
S
I
Q
K
V
V
T
R
D
G
E
T
I
-
E
Y
D
H
------------------------------
T
S
H
K
A
M
S
D
Y
T
A
Y
M
L
A
E
M
L
K
---------------
G
T
F
K
P
Y
G
S
A
Y
G
H
G
V
S
G
V
N
M
G
A
K
T
G
T
G
T
Y
G
A
E
T
Y
S
Q
Y
NLP
D
--------------
N
--------------
A
A
K
D
V
W
I
N
G
F
T
P
Q
Y
T
M
S
V
W
M
G
---------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
55.20
24%
-20
- C1 -
-
2OLU
1
?
A:
[17-565]
---------------------------------------------------------------------------------------------------------
A
K
I
Y
D
K
N
G
E
L
V
K
T
L
D
N
--
G
Q
R
H
E
H
V
N
L
K
D
V
P
K
S
M
K
D
A
V
L
A
T
E
D
N
R
F
Y
E
H
G
A
L
D
Y
-------------
G
F
G
S
E
G
A
S
T
L
T
Q
Q
V
V
K
D
A
F
L
S
----
I
G
R
K
A
Q
E
A
Y
L
S
Y
---
R
L
E
Q
E
Y
S
K
D
D
I
F
Q
V
Y
L
N
K
I
Y
Y
-----
S
D
G
V
T
G
I
K
A
A
A
K
Y
Y
F
N
K
D
L
K
D
L
N
L
A
E
E
A
Y
L
A
G
L
P
Q
V
P
N
N
Y
N
I
Y
D
H
P
---
K
A
A
E
D
------
R
K
N
T
V
L
Y
L
M
H
Y
H
K
R
I
T
D
K
Q
W
E
D
A
K
K
I
D
--------------------
L
K
A
N
L
----------------
V
N
R
T
P
E
E
R
Q
N
I
-----
D
T
N
Q
D
S
E
Y
N
S
Y
V
---
N
F
V
--------
K
S
E
L
M
N
---
N
K
A
F
K
D
E
N
L
G
N
V
L
Q
S
G
I
K
I
Y
T
N
M
D
K
D
V
Q
K
T
L
Q
N
D
V
D
N
G
S
F
Y
---
K
N
----------------------------------------------------------------------------------------------
K
--
D
Q
------------------------------------
Q
V
G
A
T
I
L
D
S
K
T
G
G
L
V
A
I
S
G
G
R
D
F
K
D
-
V
-
V
N
-
R
N
Q
A
T
D
P
H
P
T
G
S
S
L
K
P
F
L
A
Y
------
G
P
A
I
E
N
-
M
-----
K
-
W
A
T
N
-
H
A
I
--
Q
D
E
-
S
-
S
Y
Q
-
V
-----
D
G
S
T
F
R
N
Y
D
T
K
S
------
H
--
G
T
V
S
I
Y
D
A
L
R
Q
S
F
N
I
P
A
L
K
A
W
---
Q
S
V
---
K
Q
N
A
G
N
D
-
A
P
K
K
F
--
A
A
K
L
G
LN
Y
E
-
G
-
D
-
I
G
-
P
S
E
V
L
--
G
G
S
A
-
S
-
E
-
F
S
P
T
Q
L
A
S
A
F
A
A
I
A
N
G
G
T
Y
N
N
A
H
S
I
Q
K
V
V
T
R
D
G
E
T
I
-
E
Y
D
H
------------------------------
T
S
H
K
A
M
S
D
Y
T
A
Y
M
L
A
E
M
L
K
---------------
G
T
F
K
P
Y
G
S
A
Y
G
H
G
V
S
G
V
N
M
G
A
K
T
G
T
G
T
Y
G
A
E
T
Y
S
Q
Y
NLP
D
--------------
N
--------------
A
A
K
D
V
W
I
N
G
F
T
P
Q
Y
T
M
S
V
W
M
G
---------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
54.96
23%
-26
- C1 -
-
5HLB
2
PBPB_ECOLI
A:
[156-692]
------------------------------------------------------------------------------------------------------------------------------
R
L
F
V
P
R
S
G
F
P
D
L
L
V
D
T
L
L
A
T
E
D
R
H
F
Y
E
H
D
G
I
S
L
Y
S
I
G
R
A
V
L
A
N
L
T
A
G
R
T
V
Q
G
A
S
T
L
T
Q
Q
L
V
K
N
L
F
L
S
S
E
R
S
Y
W
R
K
A
N
E
A
Y
M
A
L
---
I
M
D
A
R
Y
S
K
D
R
I
L
E
L
Y
M
N
E
V
Y
L
G
Q
S
G
D
N
E
-
I
R
G
F
P
L
A
S
L
Y
Y
F
G
R
P
V
E
E
L
S
L
D
Q
Q
A
L
L
V
G
M
V
K
G
A
S
I
Y
N
P
W
R
N
P
---------
K
L
A
L
E
R
R
N
L
V
L
R
L
L
Q
Q
Q
Q
I
I
D
Q
E
L
Y
D
M
L
S
A
R
P
--------------------
L
G
V
Q
--
P
R
G
G
V
--------
I
S
P
Q
P
A
F
M
Q
L
V
--------------------
R
Q
E
L
Q
--------
A
K
-------------
L
G
D
K
V
K
D
L
S
G
V
K
I
F
T
T
F
D
S
V
A
Q
D
A
A
E
K
A
A
V
E
G
I
P
A
---
L
K
----------------------------------------------------------------------------------------------
K
Q
R
K
L
S
---------------------------------
D
L
E
T
A
I
V
V
V
D
R
F
S
G
E
V
R
A
M
V
G
G
S
E
P
Q
F
-
A
-
G
Y
-
N
R
A
M
Q
A
R
R
S
I
G
S
L
A
K
P
-
A
T
Y
------
L
T
A
L
S
Q
P
K
-----
I
-
Y
R
L
N
-
T
W
I
--
A
D
A
-
P
-
I
A
L
-
R
-----
Q
P
N
G
Q
V
W
S
P
Q
N
D
DRRYSE
S
--
G
R
V
M
L
V
D
A
L
T
R
S
M
N
V
P
---
T
V
---
N
L
G
---
M
A
L
-
G
L
P
A
V
-
T
E
T
--
W
I
K
L
G
----
V
P
-
K
-
D
Q
-
L
H
P
V
P
A
M
L
L
G
A
-
L
-
N
-
L
T
P
I
E
V
A
Q
A
F
Q
T
I
A
S
G
G
N
R
A
P
L
S
A
L
R
S
V
I
A
E
D
G
K
V
L
Y
Q
S
F
P
------------------------------
Q
A
E
R
A
V
P
A
Q
A
A
Y
L
T
L
W
T
M
Q
Q
V
V
Q
--------------
R
G
T
G
R
Q
L
G
A
K
Y
P
N
L
H
L
A
G
K
T
G
T
--------------
T
--------------
N
--------------
N
N
V
D
T
W
F
A
G
I
D
G
S
T
V
T
I
T
W
V
G
R
D
N
N
Q
P
T
K
-----
L
--
Y
--
G
A
S
G
A
M
S
I
Y
Q
R
Y
L
A
N
-----------------------------------------------------------------------------------------------------------------------
27
HHSearch
54.34
24%
17
- C1 -
-
3DWK
-
?
C:
[4-612]
-----------------------------------------------------------------------------------------------------
D
P
I
P
A
K
I
Y
D
K
N
G
E
L
V
K
T
L
D
N
--
G
Q
R
H
E
H
V
N
L
K
D
V
P
K
S
M
K
D
A
V
L
A
T
E
D
N
R
F
Y
E
H
G
A
L
D
Y
K
R
L
F
G
A
I
G
K
N
L
T
G
G
F
G
S
E
G
A
S
T
L
T
Q
Q
V
V
K
D
A
F
L
S
Q
H
K
S
I
G
R
K
A
Q
E
A
Y
L
S
Y
---
R
L
E
Q
E
Y
S
K
D
D
I
F
Q
V
Y
L
N
K
I
Y
Y
S
D
G
V
-----
T
G
I
K
A
A
A
K
Y
Y
F
N
K
D
L
K
D
L
N
L
A
E
E
A
Y
L
A
G
L
P
Q
V
P
N
N
Y
N
I
Y
D
---------
H
P
K
A
A
E
D
R
K
N
T
V
L
Y
L
M
H
Y
H
K
R
I
T
D
K
Q
W
E
D
A
K
K
I
D
--------------------
L
K
A
N
L
V
N
R
T
P
E
E
R
Q
NIDTN
Q
D
S
E
Y
N
S
Y
V
N
F
V
K
-----
S
E
--------
L
M
N
N
K
A
F
K
----------------------
D
E
N
L
G
N
V
L
Q
S
G
I
K
I
Y
T
N
M
D
K
D
V
Q
K
T
L
Q
N
D
V
D
N
G
S
F
Y
------------------------------------------------------------------------------------------------------
K
N
K
---------------------------------
D
Q
Q
V
G
A
T
I
L
D
S
K
T
G
G
L
V
A
I
S
G
G
R
D
F
K
D
-
V
V
N
R
-
N
Q
A
T
-
D
P
H
P
T
G
S
S
L
K
P
F
L
A
Y
------
G
P
A
I
E
N
-
M
-----
K
-
W
A
T
N
-
H
A
I
--
Q
D
E
-
S
S
Y
Q
V
-
D
-----
G
S
T
F
R
N
Y
D
T
K
-
S
------
H
--
G
T
V
S
I
Y
D
A
L
R
Q
S
F
N
I
P
A
L
K
A
W
---
Q
S
V
K
Q
N
A
G
N
-
D
A
--
P
-
K
K
F
--
A
A
K
L
G
--
L
N
Y
E
-
G
-
D
I
-
G
P
S
E
V
--
L
G
G
S
A
S
-
E
-
F
S
P
T
Q
L
A
S
A
F
A
A
I
A
N
G
G
T
Y
N
N
A
H
S
I
Q
K
V
V
T
R
D
G
E
T
I
E
Y
-
D
H
------------------------------
T
S
H
K
A
M
S
D
Y
T
A
Y
M
L
A
E
M
L
K
G
T
F
K
P
Y------
G
S
A
Y
G
H
---------
G
V
S
G
V
N
M
G
A
K
T
G
T
--------------
G
T
Y
G
A
E
T
Y
S
Q
Y
NLPD
N
--------------
A
A
K
D
V
W
I
N
G
F
T
P
Q
Y
T
M
S
V
W
M
G
F
S
K
V
K
Q
Y
G
ENSFV
G
--
H
--
S
Q
Q
E
Y
P
Q
F
L
Y
E
N
V
M
S
K
I
S
S
R
-
D
----
G
E
D
F
K
R
P
S
S
V
--------
S
G
S
I
P
S
I
N
V
S
--------------------------------------------------------------------------------
24
HHSearch
53.71
26%
-16
- C1 -
-
5U2G
-
PBPA_HAEIN
B:
[18-803]
-----------------------------------------------------------------------------------------------------
L
Q
Q
P
M
Q
I
Y
T
A
D
G
K
L
I
G
E
V
G
---
E
Q
R
R
I
P
V
K
L
A
D
V
P
Q
R
L
I
D
A
F
L
A
T
E
D
S
R
--------------------------------------------------------------------
N
K
Q
E
I
L
E
L
Y
L
N
K
I
F
L
G
Y
R
S
-----
Y
G
V
A
A
A
A
Q
T
Y
F
G
K
S
L
N
E
L
T
L
S
E
M
A
I
I
A
G
L
P
K
A
P
S
T
M
N
P
L
Y
---------
S
L
K
R
S
E
E
R
R
N
V
V
L
S
R
M
L
D
E
K
Y
I
S
K
E
E
Y
D
A
A
L
K
E
P
--------------------
I
V
A
S
Y
----
A
K
--------
F
E
F
R
A
D
Y
V
T
E
M
V
R
-----
Q
E
--------
M
V
R
R
F
G
---------------------------
E
E
N
A
Y
T
S
G
Y
K
V
F
T
T
V
L
S
K
D
Q
A
E
A
Q
K
A
V
R
N
N
L
I
D
---
Y
D
M
R
H
GYR
G
G
A
P
LWQKNEAAWD
N
D
R
I
V
G
F
L
R
K
LPDSEP
F
I
P
A
A
V
IGIVKG
G
A
D
I
L
L
ASG
E
K
M
T
LSTNAMRWTGRSNPVKVG
E
Q
I
W
I
H
Q
R
ANG
E
W
Q
L
G
--
Q
I
P
---------------------------------
A
A
N
S
A
L
V
S
L
N
S
D
N
G
A
I
E
A
V
V
G
G
F
S
Y
E
Q
-
S
-
K
F
-
N
R
A
T
Q
S
L
V
Q
V
G
S
S
I
K
P
F
-
I
Y
------
A
A
A
L
E
K
-
G
-----
L
--
T
L
S
-
S
V
L
--
Q
D
S
-
P
-
I
S
I
-
Q
K
PGQ
K
M
W
Q
P
K
N
S
P
D
R
-
Y
------
D
--
G
P
M
R
L
R
V
G
L
G
Q
S
K
N
I
I
A
I
R
A
I
---
Q
T
----
A
G
I
-
D
F
--
T
-
A
E
F
--
L
Q
R
F
G
--
F
K
R
D
-
Q
Y
F
A
-
S
E
A
L
A
--
L
G
A
A
---
S
-
F
T
P
L
E
M
A
R
A
Y
A
V
F
D
N
G
G
F
L
I
E
P
Y
I
I
E
K
I
Q
D
N
T
G
K
D
L
F
I
A
N
P
K
I
A
C
IECNDIPVIYGETKDKINGFASS
K
I
E
Y
A
P
R
V
I
S
G
E
L
A
F
L
I
R
S
A
L
N
T
A
I
Y
G
EQGLDWK
G
T
S
W
R
I
-------
A
Q
S
I
K
R
S
D
I
G
G
K
T
G
T
--------------
T
--------------
N
--------------
S
S
K
V
A
W
Y
A
G
F
G
A
N
L
V
T
T
T
Y
V
G
F
D
D
N
K
R
V
L
GR---
G
--
E
--
A
G
A
K
T
A
-
P
A
W
I
T
Y
-
K
T
A
L
S
D
K
P
----
E
R
K
L
S
L
P
P
K
I
V
E
K
N
I
D
T
L
T
G
L
L
S
P
N
G
G
--
R
K
E
Y
F
I
A
G
T
E
P
T
R
T
-----------------------------------------------------------------
26
HHSearch
52.17
24%
14
* C1 *
-
2OLV
1
?
A:
[13-620]
-----------------------------------------------------------------------------------------------------
D
P
I
P
A
K
I
Y
D
K
N
G
E
L
V
K
T
L
D
N
--
G
Q
R
H
E
H
V
N
L
K
D
V
P
K
S
M
K
D
A
V
L
A
T
E
D
N
R
F
Y
E
H
G
A
L
D
Y
K
R
L
F
G
A
I
G
K
---------
G
A
S
T
L
T
Q
Q
V
V
K
D
A
F
L
S
Q
H
K
S
I
G
R
K
A
Q
E
A
Y
L
S
Y
---
R
L
E
Q
E
Y
S
K
D
D
I
F
Q
V
Y
L
N
K
I
Y
Y
S
D
G
V
-----
T
G
I
K
A
A
A
K
Y
Y
F
N
K
D
L
K
D
L
N
L
A
E
E
A
Y
L
A
G
L
P
Q
V
P
N
N
Y
N
I
Y
D
---------
H
P
K
A
A
E
D
R
K
N
T
V
L
Y
L
M
H
Y
H
K
R
I
T
D
K
Q
W
E
D
A
K
K
I
D
--------------------
L
K
A
N
L
V
N
R
T
P
E
E
R
Q
NIDTN
Q
D
S
E
Y
N
S
Y
V
N
F
V
K
-----
S
E
--------
L
M
N
N
K
A
F
K
----------------------
D
E
N
L
G
N
V
L
Q
S
G
I
K
I
Y
T
N
M
D
K
D
V
Q
K
T
L
Q
N
D
V
D
N
G
S
F
Y
------------------------------------------------------------------------------------------------------
K
N
K
---------------------------------
D
Q
Q
V
G
A
T
I
L
D
S
K
T
G
G
L
V
A
I
S
G
G
R
D
F
K
D
-
V
V
N
R
-
N
Q
A
T
-
D
P
H
P
T
G
S
S
L
K
P
F
L
A
Y
------
G
P
A
I
E
N
-
M
-----
K
-
W
A
T
N
-
H
A
I
--
Q
D
E
S
S
-
Y
Q
V
-
D
-----
G
S
T
F
R
N
Y
D
T
K
-
S
------
H
--
G
T
V
S
I
Y
D
A
L
R
Q
S
F
N
I
P
A
L
K
A
W
---
Q
S
V
K
Q
N
A
G
N
-
D
A
--
P
-
K
K
F
--
A
A
K
L
G
--
L
N
Y
E
-
G
-
D
I
-
G
P
S
E
V
--
L
G
G
S
-
A
S
E
-
F
S
P
T
Q
L
A
S
A
F
A
A
I
A
N
G
G
T
Y
N
N
A
H
S
I
Q
K
V
V
T
R
D
G
E
T
I
E
Y
-
D
H
------------------------------
T
S
H
K
A
M
S
D
Y
T
A
Y
M
L
A
E
M
L
K
G
T
F
K
P
Y------
G
S
A
Y
G
H
---------
G
V
S
G
V
N
M
G
A
K
T
G
T
--------------
G
--------------
T
Y
G
A
E
T
Y
S
Q
Y
NLPDN
A
A
K
D
V
W
I
N
G
F
T
P
Q
Y
T
M
S
V
W
M
G
F
S
K
V
K
Q
Y
G
ENSFV
G
--
H
--
S
Q
Q
E
Y
P
Q
F
L
Y
E
N
V
M
S
K
I
S
S
R
-
D
----
G
E
D
F
K
R
P
S
S
V
--------
S
G
S
I
P
S
I
N
V
---------------------------------------------------------------------------------
32
HHSearch
48.67
28%
1
- C1 -
-
3ZG9
5
?
B:
[9-464]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
D
E
I
M
E
M
Y
L
N
R
S
Y
F
G
N
G
E
-----
W
G
V
E
N
A
S
L
K
Y
F
G
K
S
A
A
D
L
N
I
P
E
A
A
T
I
A
G
L
L
Q
A
P
S
A
Y
D
P
Y
Q
---------
H
I
D
K
A
T
N
R
R
N
M
V
L
N
A
M
V
E
T
G
T
I
S
K
A
E
G
D
K
Y
K
A
T
K
--------------------
I
V
L
N
D
Q
S
-
K
D
P
--------
L
A
N
K
Y
P
W
Y
V
D
A
V
I
-----
N
E
A
V
N
--------
E
A
D
I
-------------------------
T
Q
D
E
I
M
Q
K
G
Y
K
I
Y
T
E
L
D
Q
N
Y
Q
T
S
L
E
N
V
Y
N
N
D
G
L
F
---
P
S
NA--------------------------------------------------------------------------------------------
N
--
D
G
T
---------------------------------
L
V
Q
S
G
A
V
L
M
D
P
A
T
G
G
I
R
A
L
V
G
G
R
G
E
H
V
F
R
-
G
F
-
N
R
A
T
Q
M
K
A
Q
P
G
S
T
M
K
P
L
A
V
Y
------
T
P
A
L
Q
S
-
G
-----
Y
--
D
V
D
-
S
M
L
--
K
D
E
-
K
-
I
T
Y
K
G
-----
N
Y
T
P
T
N
V
G
G
V
-
Y
------
S
--
G
E
V
P
M
Y
K
A
V
A
N
S
I
N
A
P
A
V
W
L
L
---
D
Q
----
I
G
I
-
D
K
--
G
-
V
K
S
--
V
E
K
F
G
--
I
T
V
P
-
E
K
D
R
-
T
L
G
L
A
--
L
G
G
M
S
K
-
G
-
A
S
P
V
E
M
A
T
A
Y
A
T
F
A
N
N
G
A
K
P
E
S
H
I
I
T
K
I
V
D
P
S
G
N
T
V
Y
E
N
V
P
------------------------------
K
T
K
Q
I
I
S
E
T
V
S
N
E
M
T
S
M
L
L
D
V
I
N
T
-------
G
T
G
Q
S
A
---------
A
V
S
G
H
E
M
A
G
K
T
G
S
--------------
T
--------------
Q
V
PFDD
T
S
-------
G
T
K
D
Q
W
F
V
G
Y
T
P
N
L
V
G
A
V
W
M
G
Y
D
K
T
D
K
E
H
-----
Y
LT
T
--
T
S
S
A
G
V
S
S
L
A
H
Y
V
M
N
S
G
L
Q
Y
Q
-----------------------------------------------------------------------------------------------------------------
22
HHSearch
48.49
23%
18
- C1 -
-
5HLB
2
PBPB_ECOLI
A:
[133-720]
-------------------------------------------------------------------------------------------------------
R
Q
F
G
F
F
R
L
D
P
R
L
I
T
M
I
S
S
PN
G
E
Q
R
L
F
V
P
R
S
G
F
P
D
L
L
V
D
T
L
L
A
T
E
D
R
H
F
Y
E
H
D
G
I
S
L
Y
S
I
G
R
A
V
L
A
N
L
T
A
G
R
T
V
Q
G
A
S
T
L
T
Q
Q
L
V
K
N
L
F
L
S
S
E
R
S
Y
W
R
K
A
N
E
A
Y
M
A
L
---
I
M
D
A
R
Y
S
K
D
R
I
L
E
L
Y
M
N
E
V
Y
L
G
Q
S
-
G
D
N
E
I
R
G
F
P
L
A
S
L
Y
Y
F
G
R
P
V
E
E
L
S
L
D
Q
Q
A
L
L
V
G
M
V
K
G
A
S
I
Y
N
P
W
R
---------
N
P
K
L
A
L
E
R
R
N
L
V
L
R
L
L
Q
Q
Q
Q
I
I
D
Q
E
L
Y
D
M
L
S
A
R
P
--------------------
L
G
V
Q
P
--
R
-
G
G
--------
V
I
S
P
Q
P
A
F
M
Q
L
V
R
-----
Q
E
L
--------
Q
A
K
L
---------------------------
G
D
K
V
K
D
L
S
G
V
K
I
F
T
T
F
D
S
V
A
Q
D
A
A
E
K
A
A
V
E
G
I
P
A
---
L
K
----------------------------------------------------------------------------------------------
K
Q
R
K
L
S
---------------------------------
D
L
E
T
A
I
V
V
V
D
R
F
S
G
E
V
R
A
M
V
G
G
S
E
P
Q
F
-
A
-
G
Y
-
N
R
A
M
Q
A
R
R
S
I
G
S
L
A
K
P
A
-
T
Y
------
L
T
A
L
S
Q
-
P
-----
K
I
Y
R
L
N
-
T
W
I
--
A
D
A
-
P
-
I
A
L
-
R
Q
PNG
Q
V
W
S
P
Q
N
D
D
R
R
-
Y
------
S
ES
G
R
V
M
L
V
D
A
L
T
R
S
M
N
V
P
T
V
N
L
G
---
M
A
----
L
G
L
-
P
A
--
V
-
T
E
T
--
W
I
K
L
G
--
V
P
K
D
Q
L
-
H
P
-
V
P
A
M
L
--
L
G
A
L
---
N
-
L
T
P
I
E
V
A
Q
A
F
Q
T
I
A
S
G
G
N
R
A
P
L
S
A
L
R
S
V
I
A
E
D
G
K
V
L
Y
Q
S
F
P
------------------------------
Q
A
E
R
A
V
P
A
Q
A
A
Y
L
T
L
W
T
M
Q
Q
V
V
Q
R
-------
G
T
G
R
Q
L
G
-------
A
K
Y
P
N
L
H
L
A
G
K
T
G
T
--------------
T
--------------
N
--------------
N
N
V
D
T
W
F
A
G
I
D
G
S
T
V
T
I
T
W
V
G
R
D
N
N
Q
P
T
K
--------
L
--
Y
G
A
S
G
A
M
S
I
Y
Q
R
Y
L
A
N
Q
T
P
--
T
----
P
L
N
L
V
P
P
E
D
I
A
D
M
G
V
D
Y
D
G
N
F
----
V
C
S
--------------------------------------------------------------------------------
51
Fugue
47.53
22%
11
- C1 -
-
3UDI
1
?
A:
[19-727]
------------------------------------------------------------------------------------
K
P
L
Q
V
Y
-------------------------------------------------------------------------------------
T
A
D
N
Q
L
I
A
E
Y
G
G
K
L
S
I
P
V
E
Y
K
Q
I
P
P
N
F
I
H
A
F
L
A
A
EDS
S
F
F
Q
N
L
S
K
E
D
I
L
S
L
Y
V
N
K
I
F
L
G
K
N
-----
A
Y
G
I
A
A
A
A
K
I
Y
Y
N
K
S
I
N
E
L
S
I
A
Q
M
A
M
I
A
G
L
P
K
A
P
S
K
Y
N
P
V
V
N
---------
P
E
R
A
L
E
R
R
N
W
I
L
G
R
M
L
Q
L
G
Y
I
S
Q
A
E
Y
Q
K
A
V
A
E
P
INLNMPNRDLNNIH
P
Y
A
G
E
M
V
R
S
E
L
V
K
H
F
G
E
--------
Q
A
I
D
S
G
Y
K
V
Y
T
T
I
N
A
K
R
Q
A
I
A
E
K
A
V
Q
D
G
L
E
A
Y
D
R
R
H
GWRGAEAH
D
K
P
L
S
E
F
R
A
Y
A
N
T
Y
P
A
Q
V
T
K
V
N
S
S
S
F
E
A
L
M
Q
D
G
S
T
V
T
V
Q
W
S
G
M
S
W
A
R
P
Y
R
---
N
A
----------------------------------------------------------------------------------------------
N
--
S
V
G
AAPSRASQIVKVK
D
I
V
R
L
R
P
N
EAKT
A
W
S
L
V
Q
V
P
K
V
Q
G
Q
L
I
A
I
N
P
N
D
G
S
I
E
A
I
V
G
G
Y
N
F
Y
Q
-
S
-
K
F
-
N
R
A
L
Q
G
W
R
Q
P
G
S
T
I
K
P
F
L
-
Y
------
A
L
A
L
E
R
-
G
-----
M
--
T
P
Y
-
S
M
V
--
N
D
S
-
P
-
I
T
I
-
G
-----
K
W
T
P
K
N
S
-
D
G
R
Y
------
L
--
G
M
I
P
L
R
R
A
L
Y
L
S
R
N
T
---
V
S
V
---
R
L
L
---
Q
T
V
-
G
I
E
R
T
-
R
Q
L
--
F
M
D
F
G
--
L
Q
E
D
-
Q
-
I
P
-
R
N
Y
T
I
--
A
L
G
T
-
P
-
Q
-
V
L
P
I
Q
M
A
T
G
Y
A
T
F
A
N
G
G
Y
R
V
Q
P
H
F
I
Q
R
I
E
D
A
Y
G
K
V
I
Y
E
A
K
P
------------------------------
E
Y
A
C
I
P
C
I
N
A
Y
R
Q
A
Q
R
I
L
K
S
S
S
A
Y
-------
D
M
A
N
I
L
R
D
V
I
E
H
G
T
G
K
I
G
R
S
D
L
G
G
K
T
G
T
--------------
T
--------------
N
--------------
D
A
K
D
A
W
F
A
G
F
N
G
K
L
V
T
V
T
W
V
G
F
D
Q
P
T
T
L
G
-----
R
--
R
EY
G
G
I
A
A
L
P
I
W
I
N
F
M
G
Q
A
L
Q
G
T
P
A
A
W
V
R
L
E
----------------------------------------------------------------------------------------------------------
33
HHSearch
47.41
28%
4
- C1 -
-
3ZG8
4
?
B:
[7-464]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
S
K
D
E
I
M
E
M
Y
L
N
R
S
Y
F
G
N
G
E
-----
W
G
V
E
N
A
S
L
K
Y
F
G
K
S
A
A
D
L
N
I
P
E
A
A
T
I
A
G
L
L
Q
A
P
S
A
Y
D
P
Y
Q
---------
H
I
D
K
A
T
N
R
R
N
M
V
L
N
A
M
V
E
T
G
T
I
S
K
A
E
G
D
K
Y
K
A
T
K
--------------------
I
V
L
N
D
Q
S
-
K
D
P
--------
L
A
N
K
Y
P
W
Y
V
D
A
V
I
-----
N
E
A
V
N
--------
E
A
D
I
-------------------------
T
Q
D
E
I
M
Q
K
G
Y
K
I
Y
T
E
L
D
Q
N
Y
Q
T
S
L
E
N
V
Y
N
N
D
G
L
F
---
P
S
NA--------------------------------------------------------------------------------------------
N
--
D
G
T
---------------------------------
L
V
Q
S
G
A
V
L
M
D
P
A
T
G
G
I
R
A
L
V
G
G
R
G
E
H
V
F
R
-
G
F
-
N
R
A
T
Q
M
K
A
Q
P
G
S
T
M
K
P
L
A
V
Y
------
T
P
A
L
Q
S
-
G
-----
Y
--
D
V
D
-
S
M
L
--
K
D
E
-
K
-
I
T
Y
K
G
-----
N
Y
T
P
T
N
V
G
G
V
-
Y
------
S
--
G
E
V
P
M
Y
K
A
V
A
N
S
I
N
A
P
A
V
W
L
L
---
D
Q
----
I
G
I
-
D
K
--
G
-
V
K
S
--
V
E
K
F
G
--
I
T
V
P
-
E
K
D
R
-
T
L
G
L
A
--
L
G
G
M
S
K
-
G
-
A
S
P
V
E
M
A
T
A
Y
A
T
F
A
N
N
G
A
K
P
E
S
H
I
I
T
K
I
V
D
P
S
G
N
T
V
Y
E
N
V
P
------------------------------
K
T
K
Q
I
I
S
E
T
V
S
N
E
M
T
S
M
L
L
D
V
I
N
T
-------
G
T
G
Q
S
A
---------
A
V
S
G
H
E
M
A
G
K
T
G
S
--------------
T
--------------
Q
V
PFDD
T
S
-------
G
T
K
D
Q
W
F
V
G
Y
T
P
N
L
V
G
A
V
W
M
G
Y
D
K
T
D
K
E
H
-----
Y
LT
T
--
T
S
S
A
G
V
S
S
L
A
H
Y
V
M
N
S
G
L
Q
Y
Q
-----------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
46.35
29%
0
- C1 -
-
3ZG9
5
?
B:
[9-433]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
D
E
I
M
E
M
Y
L
N
R
S
Y
F
G
N
G
E
-----
W
G
V
E
N
A
S
L
K
Y
F
G
K
S
A
A
D
L
N
I
P
E
A
A
T
I
A
G
L
L
Q
A
P
S
A
Y
D
P
Y
Q
H
---------
I
D
K
A
T
N
R
R
N
M
V
L
N
A
M
V
E
T
G
T
I
S
K
A
E
G
D
K
Y
K
----------------------------------------------------
A
T
K
-----
I
V
L
N
D
Q
S
K
D
P
L
A
N
K
Y
P
W
Y
--------
V
D
A
V
I
N
E
A
V
N
E
--
A
D
I
T
Q
D
E
I
M
Q
K
G
Y
K
I
Y
T
E
L
D
Q
N
Y
Q
T
S
L
E
N
V
Y
N
N
D
G
L
F
PSN
A
N
----------------------------------------------------------------------------------------------
D
--
G
T
----------------------------------
L
V
Q
S
G
A
V
L
M
D
P
A
T
G
G
I
R
A
L
V
G
G
R
G
E
H
V
-
F
-
R
G
F
N
R
A
T
Q
M
K
A
Q
P
G
S
T
M
K
P
L
A
V
Y
------
T
P
A
L
Q
S
-
G
YDVD
S
M
-
L
K
D
E
-
K
I
T
YK
G
N
Y
T
P
-
T
N
V
-
G
-----
G
----
V
Y
-----------
S
--
G
E
V
P
M
Y
K
A
V
A
N
S
I
N
A
P
A
V
W
------
L
L
---
D
Q
I
-
G
I
D
---
K
G
V
K
S
V
E
K
F
G
--
I
T
V
P
-
E
-
K
D
R
T
L
G
L
A
--
L
G
G
M
-
S
-
K
G
A
S
P
V
E
M
A
T
A
Y
A
T
F
A
N
N
G
A
K
P
E
S
H
I
I
T
K
I
V
D
P
S
G
N
T
V
Y
E
N
V
P
------------------------------
K
T
K
Q
I
I
S
E
T
V
S
N
E
M
T
S
M
L
L
D
V
I
N
T
-------
G
---------
T
G
Q
S
A
A
V
S
G
H
E
M
A
G
K
T
G
S
T
Q
V
PFDD-------
T
--------------
S
--------------
G
T
K
D
Q
W
F
V
G
Y
T
P
N
L
V
G
A
V
W
M
G
Y
D
-------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
46.26
29%
2
- C1 -
-
3ZG8
4
?
B:
[7-433]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
S
K
D
E
I
M
E
M
Y
L
N
R
S
Y
F
G
N
G
E
-----
W
G
V
E
N
A
S
L
K
Y
F
G
K
S
A
A
D
L
N
I
P
E
A
A
T
I
A
G
L
L
Q
A
P
S
A
Y
D
P
Y
Q
H
---------
I
D
K
A
T
N
R
R
N
M
V
L
N
A
M
V
E
T
G
T
I
S
K
A
E
G
D
K
Y
K
----------------------------------------------------
A
T
K
-----
I
V
L
N
D
Q
S
K
D
P
L
A
N
K
Y
P
W
Y
--------
V
D
A
V
I
N
E
A
V
N
E
--
A
D
I
T
Q
D
E
I
M
Q
K
G
Y
K
I
Y
T
E
L
D
Q
N
Y
Q
T
S
L
E
N
V
Y
N
N
D
G
L
F
PSN
A
N
----------------------------------------------------------------------------------------------
D
--
G
T
----------------------------------
L
V
Q
S
G
A
V
L
M
D
P
A
T
G
G
I
R
A
L
V
G
G
R
G
E
H
V
-
F
-
R
G
F
N
R
A
T
Q
M
K
A
Q
P
G
S
T
M
K
P
L
A
V
Y
------
T
P
A
L
Q
S
-
G
YDVDS
M
-
L
K
D
E
-
K
I
T
YK
G
N
Y
T
P
-
T
N
V
-
G
-----
G
----
V
Y
-----------
S
--
G
E
V
P
M
Y
K
A
V
A
N
S
I
N
A
P
A
V
W
------
L
L
---
D
Q
I
-
G
I
D
---
K
G
V
K
S
V
E
K
F
G
--
I
T
V
P
-
E
-
K
D
R
T
L
G
L
A
--
L
G
G
M
-
S
-
K
G
A
S
P
V
E
M
A
T
A
Y
A
T
F
A
N
N
G
A
K
P
E
S
H
I
I
T
K
I
V
D
P
S
G
N
T
V
Y
E
N
V
P
------------------------------
K
T
K
Q
I
I
S
E
T
V
S
N
E
M
T
S
M
L
L
D
V
I
N
T
-------
G
---------
T
G
Q
S
A
A
V
S
G
H
E
M
A
G
K
T
G
S
T
Q
V
PFDD-------
T
--------------
S
--------------
G
T
K
D
Q
W
F
V
G
Y
T
P
N
L
V
G
A
V
W
M
G
Y
D
-------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
45.90
29%
2
- C1 -
-
3ZGA
4
?
B:
[7-433]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
S
K
D
E
I
M
E
M
Y
L
N
R
S
Y
F
G
N
G
E
-----
W
G
V
E
N
A
S
L
K
Y
F
G
K
S
A
A
D
L
N
I
P
E
A
A
T
I
A
G
L
L
Q
A
P
S
A
Y
D
P
Y
Q
H
---------
I
D
K
A
T
N
R
R
N
M
V
L
N
A
M
V
E
T
G
T
I
S
K
A
E
G
D
K
Y
K
----------------------------------------------------
A
T
K
-----
I
V
L
N
D
Q
S
K
D
P
L
A
N
K
Y
P
W
Y
--------
V
D
A
V
I
N
E
A
V
N
E
--
A
D
I
T
Q
D
E
I
M
Q
K
G
Y
K
I
Y
T
E
L
D
Q
N
Y
Q
T
S
L
E
N
V
Y
N
N
D
G
L
F
PSN
A
N
----------------------------------------------------------------------------------------------
D
--
G
T
----------------------------------
L
V
Q
S
G
A
V
L
M
D
P
A
T
G
G
I
R
A
L
V
G
G
R
G
E
H
V
-
F
-
R
G
F
N
R
A
T
Q
M
K
A
Q
P
G
S
T
M
K
P
L
A
V
Y
------
T
P
A
L
Q
S
-
G
YDVDS
M
-
L
K
D
E
-
K
I
T
YK
G
N
Y
T
P
-
T
N
V
-
G
-----
G
----
V
Y
-----------
S
--
G
E
V
P
M
Y
K
A
V
A
N
S
I
N
A
P
A
V
W
------
L
L
---
D
Q
I
-
G
I
D
---
K
G
V
K
S
V
E
K
F
G
--
I
T
V
P
-
E
-
K
D
R
T
L
G
L
A
--
L
G
G
M
-
S
-
K
G
A
S
P
V
E
M
A
T
A
Y
A
T
F
A
N
N
G
A
K
P
E
S
H
I
I
T
K
I
V
D
P
S
G
N
T
V
Y
E
N
V
P
------------------------------
K
T
K
Q
I
I
S
E
T
V
S
N
E
M
T
S
M
L
L
D
V
I
N
T
-------
G
---------
T
G
Q
S
A
A
V
S
G
H
E
M
A
G
K
T
G
S
T
Q
V
PFDD-------
T
--------------
S
--------------
G
T
K
D
Q
W
F
V
G
Y
T
P
N
L
V
G
A
V
W
M
G
Y
D
-------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
44.82
28%
-0
- C1 -
-
3ZG7
2
?
B:
[8-433]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
K
D
E
I
M
E
M
Y
L
N
R
S
Y
F
G
N
G
E
-----
W
G
V
E
N
A
S
L
K
Y
F
G
K
S
A
A
D
L
N
I
P
E
A
A
T
I
A
G
L
L
Q
A
P
S
A
Y
D
P
Y
Q
H
---------
I
D
K
A
T
N
R
R
N
M
V
L
N
A
M
V
E
T
G
T
I
S
K
A
E
G
D
K
Y
K
----------------------------------------------------
A
T
K
-----
I
V
L
N
D
Q
S
K
D
P
L
A
N
K
Y
P
W
Y
--------
V
D
A
V
I
N
E
A
V
N
E
--
A
D
I
T
Q
D
E
I
M
Q
K
G
Y
K
I
Y
T
E
L
D
Q
N
Y
Q
T
S
L
E
N
V
Y
N
N
D
G
L
F
PSN
A
N
----------------------------------------------------------------------------------------------
D
--
G
T
----------------------------------
L
V
Q
S
G
A
V
L
M
D
P
A
T
G
G
I
R
A
L
V
G
G
R
G
E
H
V
-
F
-
R
G
F
N
R
A
T
Q
M
K
A
Q
P
G
S
T
M
K
P
L
A
V
Y
T
P
A
L
Q
S
G
Y
D
V
D
S
-
M
-----
L
-
K
D
E
K
I
T
Y
K
--
G
N
Y
T
P
-
T
N
V
-
G
-----
G
----
V
Y
-----------
S
--
G
E
V
P
M
Y
K
A
V
A
N
S
I
N
A
P
A
V
W
------
L
L
---
D
Q
I
-
G
I
D
---
K
G
V
K
S
V
E
K
F
G
--
I
T
V
P
-
E
-
K
D
R
T
L
G
L
A
--
L
G
G
M
-
S
-
K
G
A
S
P
V
E
M
A
T
A
Y
A
T
F
A
N
N
G
A
K
P
E
S
H
I
I
T
K
I
V
D
P
S
G
N
T
V
Y
E
N
V
P
------------------------------
K
T
K
Q
I
I
S
E
T
V
S
N
E
M
T
S
M
L
L
D
V
I
N
T
-------
G
---------
T
G
Q
S
A
A
V
S
G
H
E
M
A
G
K
T
G
S
T
Q
V
PFDD-------
T
--------------
S
--------------
G
T
K
D
Q
W
F
V
G
Y
T
P
N
L
V
G
A
V
W
M
G
Y
D
-------------------------------------------------------------------------------------------------------------------------------------------------------