@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : spr1910: (2018-01-22 )
MHIFDELKERGLIFQTTDEEALRKALEEGQVSYYTGYDPTADSLHLGHLVAILTSRRLQLAGHKPYALVGGATGLIGDPSFKDAERSLQTKDTVDGWVKSIQGQLSRFLDFENGENKAVMVNNYDWFGSISFIDFLRDIGKYFTVNYMMSKESVKKRIETGISYTEFAYQIMQGYDFFVLNQDHNVTLQIGGSDQWGNMTAGTELLRRKADKTGHVITVPLITDATGKKFGKSEGNAVWLNPEKTSPYEMYQFWMNVMDADAVRFLKIFTFLSLDEIEDIRKQFEAAPHERLAQKVLAREVVTLVHGEEAYKEALNITEQLFAGNIKNLSVKELKQGLRGVPNYQVQADENNNIVELLVSSGIVNSKRQAREDVQNGAIYVNGDRIQELDYVLSDADKLENELTVIRRGKKKYFVLTY
Atome Classification :
(35 SA)
.........10......-..20---.......----.----.30..----......40........50........60........70........80..-......90........100.......110---..----------.----.-..--...-----------120.......130.......140.......150......---.---160.--........170.......180.......190.......200.....--.-.210----------------..-...---------------...220.......230..-.....240.-......250--........260.......270.......280.......290.......300.......310.......320.-..-....330.......340......-.350-.......360.......370.......380.......390.......400.......410......
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MH
I
F
D
E
L
K
ERG
L
I
F
QTT-
D
E
E
----
A
L
R
K
A
L
E
----E----G
Q
V
S
Y
----YTGYDPTADS
L
H
L
G
H
L
V
A
I
L
T
SR
R
L
QLAGHK
P
Y
A
L
VGGATGLIGDPS
F
K
D
-
A
E
R
SLQTK
D
T
V
D
G
W
V
K
S
I
Q
G
Q
L
S
R
F
L
D-----FE----------N----G-EN--
K
A
V
-----------
M
VNNYDWFGS
I
S
F
I
D
F
L
R
D
I
G
K
Y
F
T
V
N
Y
M
M
S
K
E
S
V
K
K
R
I
---
E
---T--G--I
S
Y
T
E
F
A
Y
Q
I
M
QG
Y
D
F
F
V
L
NQDH
N
V
T
L
Q
IGGSDQWGN
M
T
A
G
T
E
L
L
R
--
R
-KAD-----------------KT-G
H
V
---------------
I
T
V
P
L
I
TDATGKKFGKSE-G
N
A
V
W
LNPE-KT
S
P
Y
E
M
Y
---
Q
F
W
M
N
VM
D
A
D
A
V
R
F
L
K
I
F
T
F
L
S
L
D
E
I
E
D
I
R
K
Q
F
EAA
P
H
E
R
L
A
Q
K
V
L
A
R
E
V
V
T
L
VHG
E
E
A
Y
K
E
A
L
N
I
T
E
Q
L
F
A-GN-IKNL
S
V
K
E
L
K
Q
G
LRGVPN
Y
Q
V
Q
A-DENN-
N
I
V
E
L
L
V
SSGIVN
S
K
R
Q
A
R
E
DVQNG
A
I
Y
VNG
D
R
I
Q
E
L
D
Y
V
LS
D
A
D
K
L
E
N
E
L
T
V
I
RRGK
K
K
Y
F
V
L
TY
171
HHSearch
91.32
46%
-34
- C3 -
-
2JAN
-
SYY_MYCTU
A:
[5-421]
--
I
L
D
E
L
S
W
R
G
L
I
A
Q
S
T
-
D
L
D
----
T
L
A
A
E
A
Q
----
R
----
G
P
M
T
V
----
Y
A
G
F
D
P
T
A
P
S
L
H
A
G
H
L
V
P
L
L
T
L
R
R
F
Q
R
A
G
H
R
P
I
V
L
A
G
G
A
T
G
M
I
G
D
P
R
D
V
--
G
E
R
S
L
N
E
A
D
T
V
A
E
W
T
E
R
I
R
G
Q
L
E
R
F
V
D
-----
F
D
----------
D
----
S
-
P
M
--
G
A
I
-----------
V
E
N
N
L
E
W
T
G
S
L
S
A
I
E
F
L
R
D
I
G
K
H
F
S
V
N
V
M
L
A
R
D
T
I
R
R
R
L
---
A
G--
E
--
G
--
I
S
Y
T
E
F
S
Y
L
L
L
Q
A
N
D
Y
V
E
L
H
R
R
H
G
C
T
L
Q
I
G
G
A
D
Q
W
G
N
I
I
A
G
V
R
L
V
R
--
Q
-
K
L
G
-----------------
A
T
-
V
H
A
---------------
L
T
V
P
L
V
T
A
A
D
G
T
K
F
G
K
S
T
G
G
G
S
L
W
L
D
P
Q
-
M
T
S
P
Y
A
W
Y
---
Q
Y
F
V
N
T
A
D
A
D
V
I
R
Y
L
R
W
F
T
F
L
S
A
D
E
L
A
E
L
E
Q
A
T
A
Q
R
P
Q
Q
R
A
A
Q
R
R
L
A
S
E
L
T
V
L
V
H
G
E
A
A
T
A
A
V
E
H
A
S
R
A
L
F
G
-
R
G
E
L
A
R
L
D
E
A
T
L
A
A
A
L
R
E
T
T
V
--
A
E
L
K
P
G
S
P
D
G
I
V
D
L
L
V
A
S
G
L
S
A
S
K
G
A
A
R
R
T
I
H
E
G
G
V
S
V
N
N
I
R
V
D
N
E
E
W
V
P
Q
S
S
D
F
L
H
G
R
W
L
V
L
R
R
G
K
R
S
I
A
G
V
E
-
170
HHSearch
89.93
46%
-34
- C3 -
-
2JAN
-
SYY_MYCTU
C:
[5-421]
--
I
L
D
E
L
S
W
R
G
L
I
A
Q
S
T
-
D
L
D
----
T
L
A
A
E
A
Q
----
R
----
G
P
M
T
V
----
Y
A
G
F
D
P
T
A
P
S
L
H
A
G
H
L
V
P
L
L
T
L
R
R
F
Q
R
A
G
H
R
P
I
V
L
A
G
G
A
T
G
M
I
G
---------------
D
T
V
A
E
W
T
E
R
I
R
G
Q
L
E
R
F
V
D
-----
F
D
----------
D
----
S
-
P
M
--
G
A
I
-----------
V
E
N
N
L
E
W
T
G
S
L
S
A
I
E
F
L
R
D
I
G
K
H
F
S
V
N
V
M
L
A
R
D
T
I
R
R
R
L
---
A
G
--
E
--
G
--
I
S
Y
T
E
F
S
Y
L
L
L
Q
A
N
D
Y
V
E
L
H
R
R
H
G
C
T
L
Q
I
G
G
A
D
Q
W
G
N
I
I
A
G
V
R
L
V
R
--
Q
-
K
L
G
-----------------
A
T
-
V
H
A
---------------
L
T
V
P
L
V
T
A
A
D
G
T
K
F
G
K
S
T
G
G
G
S
L
W
L
D
P
Q
-
M
T
S
P
Y
A
W
Y
---
Q
Y
F
V
N
T
A
D
A
D
V
I
R
Y
L
R
W
F
T
F
L
S
A
D
E
L
A
E
L
E
Q
A
T
A
Q
R
P
Q
Q
R
A
A
Q
R
R
L
A
S
E
L
T
V
L
V
H
G
E
A
A
T
A
A
V
E
H
A
S
R
A
L
F
G
-
R
G
E
L
A
R
L
D
E
A
T
L
A
A
A
L
R
E
T
T
V
--
A
E
L
K
P
G
S
P
D
G
I
V
D
L
L
V
A
S
G
L
S
A
S
K
G
A
A
R
R
T
I
H
E
G
G
V
S
V
N
N
I
R
V
D
N
E
E
W
V
P
Q
S
S
D
F
L
H
G
R
W
L
V
L
R
R
G
K
R
S
I
A
G
V
E
-
14
PsiBlast_PDB
88.14
45%
-16
- C3 -
-
2JAN
-
SYY_MYCTU
A:
[5-416]
--
I
L
D
E
L
S
W
R
G
L
I
A
Q
S
T
-
D
L
D
----
T
L
A
A
E
A
Q
----
R
----
G
P
M
T
V
----
Y
A
G
F
D
P
T
A
P
S
L
H
A
G
H
L
V
P
L
L
T
L
R
R
F
Q
R
A
G
H
R
P
I
V
L
A
G
G
A
T
G
M
I
G
D
P
--
R
D
V
G
E
R
S
L
N
E
A
D
T
V
A
E
W
T
E
R
I
R
G
Q
L
E
R
F
V
D
-----
F
D
----------
D
----
S
-
P
M
--
G
A
I
-----------
V
E
N
N
L
E
W
T
G
S
L
S
A
I
E
F
L
R
D
I
G
K
H
F
S
V
N
V
M
L
A
R
D
T
I
R
R
R
L
---
A
G--
E
--
G
--
I
S
Y
T
E
F
S
Y
L
L
L
Q
A
N
D
Y
V
E
L
H
R
R
H
G
C
T
L
Q
I
G
G
A
D
Q
W
G
N
I
I
A
G
V
R
L
V
R
--
Q
-
K
L
G
-----------------
A
T
-
V
H
A
---------------
L
T
V
P
L
V
T
A
A
D
G
T
K
F
G
K
S
T
G
G
G
S
L
W
L
D
P
Q
-
M
T
S
P
Y
A
W
Y
---
Q
Y
F
V
N
T
A
D
A
D
V
I
R
Y
L
R
W
F
T
F
L
S
A
D
E
L
A
E
L
E
Q
A
T
A
Q
R
P
Q
Q
R
A
A
Q
R
R
L
A
S
E
L
T
V
L
V
H
G
E
A
A
T
A
A
V
E
H
A
S
R
A
L
F
G
R
G
E
-
L
A
R
L
D
E
A
T
L
A
A
A
L
R
E
T
T
V
A
E
L
K
P
-
G
S
P
D
-
G
I
V
D
L
L
V
A
S
G
L
S
A
S
K
G
A
A
R
R
T
I
H
E
G
G
V
S
V
N
N
I
R
V
D
N
E
E
W
V
P
Q
S
S
D
F
L
H
G
R
W
L
V
L
R
R
G
K
R
S
------
168
HHSearch
84.45
57%
-90
- C3 -
-
2TS1
-
SYY_GEOSE
A:
[1-319]
M
D
L
L
A
E
L
Q
W
R
G
L
V
N
Q
T
T
-
D
E
D
----
G
L
R
K
L
L
N
----
E
----
E
R
V
T
L
----
Y
C
G
F
D
P
T
A
D
S
L
H
I
G
H
L
A
T
I
L
T
M
R
R
F
Q
Q
A
G
H
R
P
I
A
L
V
G
G
A
T
G
L
I
G
D
P
S
G
K
K
-
S
E
R
T
L
N
A
K
E
T
V
E
A
W
S
A
R
I
K
E
Q
L
G
R
F
L
D
-----
F
E
----------
A
----
D
-
G
N
--
P
A
K
-----------
I
K
N
N
Y
D
W
I
G
P
L
D
V
I
T
F
L
R
D
V
G
K
H
F
S
V
N
Y
M
M
A
K
E
S
V
Q
S
R
I
---
E
---
T
--
G
--
I
S
F
T
E
F
S
Y
M
M
L
Q
A
Y
D
F
L
R
L
Y
E
T
E
G
C
R
L
Q
I
G
G
S
D
Q
W
G
N
I
T
A
G
L
E
L
I
R
--
K
-
T
K
G
------------------
R
-
A
F
G
---------------
L
T
I
P
L
V
T
K
A
D
G
T
K
F
G
K
T
E
-
S
G
T
I
W
L
D
K
E
-
K
T
S
P
Y
E
F
Y
---
Q
F
W
I
N
T
D
D
R
D
V
I
R
Y
L
K
Y
F
T
F
L
S
K
E
E
I
E
A
L
E
Q
E
L
R
E
A
P
E
K
R
A
A
Q
K
T
L
A
E
E
V
T
K
L
V
H
G
E
E
A
L
R
Q
A
I
R
I
S
--------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
82.74
58%
-46
- C3 -
-
1TYB
1
SYY_GEOSE
E:
[1-319]
M
D
L
L
A
E
L
Q
W
R
G
L
V
N
Q
T
T
-
D
E
D
----
G
L
R
K
L
L
N
----
E
----
E
R
V
T
L
----
Y
C
G
F
D
P
T
A
D
S
L
H
I
G
H
L
A
G
I
L
T
M
R
R
F
Q
Q
A
G
H
R
P
I
A
L
V
G
G
A
T
G
L
I
G
D
P
S
G
K
K
-
S
E
R
T
L
N
A
K
E
T
V
E
A
W
S
A
R
I
K
E
Q
L
G
R
F
L
D
-----
F
E
----------
A
----
D
-
G
N
--
P
A
K
-----------
I
K
N
N
Y
D
W
I
G
P
L
D
V
I
T
F
L
R
D
V
G
K
H
F
S
V
N
Y
M
M
A
K
E
S
V
Q
S
R
I
---
E
---
T
--
G
--
I
S
F
T
E
F
S
Y
M
M
L
Q
A
Y
D
F
L
R
L
Y
E
T
E
G
C
R
L
Q
I
G
G
S
D
Q
W
G
N
I
T
A
G
L
E
L
I
R
--
K
T
K
G
-------------------
R
-
A
F
G
---------------
L
T
I
P
L
V
T
K
A
D
G
T
K
F
G
K
T
E
-
S
G
T
I
W
L
D
K
E
-
K
T
S
P
Y
E
F
Y
---
Q
F
W
I
N
T
D
D
R
D
V
I
R
Y
L
K
Y
F
T
F
L
S
K
E
E
I
E
A
L
E
Q
E
L
R
E
A
P
E
K
R
A
A
Q
K
T
L
A
E
E
V
T
K
L
V
H
G
E
E
A
L
R
Q
A
I
R
I
S
--------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
82.39
53%
-53
- C3 -
-
1JIL
-
SYY_STAAE
A:
[5-324]
--
L
I
E
D
L
K
W
R
G
L
I
Y
Q
Q
T
-
D
E
Q
----
G
I
E
D
L
L
N
----
K
----
E
Q
V
T
L
----
Y
C
G
A
D
P
T
A
D
S
L
H
I
G
H
L
L
P
F
L
T
L
R
R
F
Q
E
H
G
H
R
P
I
V
L
I
G
G
G
T
G
M
I
G
D
P
S
G
K
S
-
E
E
R
V
L
Q
T
E
E
Q
V
D
K
N
I
E
G
I
S
K
Q
M
H
N
I
F
E
-----
F
-----------
G
----
T
-
D
H
--
G
A
V
-----------
L
V
N
N
R
D
W
L
G
Q
I
S
L
I
S
F
L
R
D
Y
G
K
H
V
G
V
N
Y
M
L
G
K
D
S
I
Q
S
R
L
---
E
---
H
--
G
--
I
S
Y
T
E
F
T
Y
T
I
L
Q
A
I
D
F
G
H
L
N
R
E
L
N
C
K
I
Q
V
G
G
S
D
Q
W
G
N
I
T
S
G
I
E
L
M
R
--
R
-
M
Y
G
-----------------
Q
T
D
A
Y
G
---------------
L
T
I
P
L
V
T
K
S
D
G
K
K
F
G
K
S
E
-
S
G
A
V
W
L
D
A
E
-
K
T
S
P
Y
E
F
Y
---
Q
F
W
I
N
Q
S
D
E
D
V
I
K
F
L
K
Y
F
T
F
L
G
K
E
E
I
D
R
L
E
Q
S
K
N
E
A
P
H
L
R
E
A
Q
K
T
L
A
E
E
V
T
K
F
I
H
G
E
D
A
L
N
D
A
I
R
I
S
Q
A
L
F
----------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
82.33
56%
-41
- C3 -
-
1WQ3
1
SYY_ECOLI
A:
[5-320]
-
N
L
I
K
Q
L
Q
E
R
G
L
V
A
Q
V
T
-
D
E
E
----
A
L
A
E
R
L
A
----
Q
----
G
P
I
A
L
----
V
C
G
F
D
P
T
A
D
S
L
H
L
G
H
L
V
P
L
L
C
L
K
R
F
Q
Q
A
G
H
K
P
V
A
L
V
G
G
A
T
G
L
I
G
D
P
S
F
K
A
-
A
E
R
K
L
N
T
E
E
T
V
Q
E
W
V
D
K
I
R
K
Q
V
A
P
F
L
D
-----
F
D
----------
C
----
G
-
E
N
--
S
A
I
-----------
A
A
N
N
Y
D
W
F
G
N
M
N
V
L
T
F
L
R
D
I
G
K
H
F
S
V
N
Q
M
I
N
K
E
A
V
K
Q
R
L
N
RE
D
---
Q
--
G
--
I
S
F
T
E
F
S
Y
N
L
L
Q
G
Y
D
F
A
C
L
N
K
Q
Y
G
V
V
L
C
I
G
G
S
D
Q
W
G
N
I
T
S
G
I
D
L
T
R
--
R
-
L
H
Q
-----------------
N
Q
-
V
F
G
---------------
L
T
V
P
L
I
T
K
A
D
G
T
K
F
G
K
T
E
-
G
G
A
V
W
L
D
P
K
-
K
T
S
P
Y
K
F
Y
---
Q
F
W
I
N
T
A
D
A
D
V
Y
R
F
L
K
F
F
T
F
M
S
I
E
E
I
N
A
L
E
E
E
D
K
N
S
G
K
A
P
R
A
Q
Y
V
L
A
E
Q
V
T
R
L
V
H
G
E
E
G
L
Q
A
A
------------------------------------------------------------------------------------------------------------
169
HHSearch
82.16
53%
-53
- C3 -
-
1JIL
-
SYY_STAAE
A:
[4-324]
-
V
L
I
E
D
L
K
W
R
G
L
I
Y
Q
Q
T
-
D
E
Q
----
G
I
E
D
L
L
N
----
K
----
E
Q
V
T
L
----
Y
C
G
A
D
P
T
A
D
S
L
H
I
G
H
L
L
P
F
L
T
L
R
R
F
Q
E
H
G
H
R
P
I
V
L
I
G
G
G
T
G
M
I
G
D
P
S
G
K
S
-
E
E
R
V
L
Q
T
E
E
Q
V
D
K
N
I
E
G
I
S
K
Q
M
H
N
I
F
E
-----
F
G
---------------
T
-
D
H
--
G
A
V
-----------
L
V
N
N
R
D
W
L
G
Q
I
S
L
I
S
F
L
R
D
Y
G
K
H
V
G
V
N
Y
M
L
G
K
D
S
I
Q
S
R
L
---
E
---
H
--
G
--
I
S
Y
T
E
F
T
Y
T
I
L
Q
A
I
D
F
G
H
L
N
R
E
L
N
C
K
I
Q
V
G
G
S
D
Q
W
G
N
I
T
S
G
I
E
L
M
R
--
R
-
M
Y
G
Q----------------
T
D
-
A
Y
G
---------------
L
T
I
P
L
V
T
K
S
D
G
K
K
F
G
K
S
E
-
S
G
A
V
W
L
D
A
E
-
K
T
S
P
Y
E
F
Y
---
Q
F
W
I
N
Q
S
D
E
D
V
I
K
F
L
K
Y
F
T
F
L
G
K
E
E
I
D
R
L
E
Q
S
K
N
E
A
P
H
L
R
E
A
Q
K
T
L
A
E
E
V
T
K
F
I
H
G
E
D
A
L
N
D
A
I
R
I
S
Q
A
L
F
----------------------------------------------------------------------------------------------------
179
HHSearch
81.98
57%
-68
- C3 -
-
1TYD
1
SYY_GEOSE
E:
[1-319]
M
D
L
L
A
E
L
Q
W
R
G
L
V
N
Q
T
T
-
D
E
D
----
G
L
R
K
L
L
N
----
E
----
E
R
V
T
L
----
Y
C
G
F
D
P
T
A
D
S
L
H
I
G
H
L
A
S
I
L
T
M
R
R
F
Q
Q
A
G
H
R
P
I
A
L
V
G
G
A
T
G
L
I
G
D
P
S
G
K
K
-
S
E
R
T
L
N
A
K
E
T
V
E
A
W
S
A
R
I
K
E
Q
L
G
R
F
L
D
-----
F
E
----------
A
----
D
-
G
N
--
P
A
K
-----------
I
K
N
N
Y
D
W
I
G
P
L
D
V
I
T
F
L
R
D
V
G
K
H
F
S
V
N
Y
M
M
A
K
E
S
V
Q
S
R
I
---
E
---
T
--
G
--
I
S
F
T
E
F
S
Y
M
M
L
Q
A
Y
D
F
L
R
L
Y
E
T
E
G
C
R
L
Q
I
G
G
S
D
Q
W
G
N
I
T
A
G
L
E
L
I
R
--
K
-
T
K
G
------------------
R
-
A
F
G
---------------
L
T
I
P
L
V
T
K
A
D
G
T
K
F
G
K
T
E
-
S
G
T
I
W
L
D
-
K
---
E
K
T
S
P
Y
EFY
Q
F
W
I
N
T
D
D
R
D
V
I
R
Y
L
K
Y
F
T
F
L
S
K
E
E
I
E
A
L
E
Q
E
L
R
E
A
P
E
K
R
A
A
Q
K
T
L
A
E
E
V
T
K
L
V
H
G
E
E
A
L
R
Q
A
I
R
I
S
--------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
81.97
58%
-51
- C3 -
-
1TYD
1
SYY_GEOSE
E:
[1-319]
M
D
L
L
A
E
L
Q
W
R
G
L
V
N
Q
T
T
-
D
E
D
----
G
L
R
K
L
L
N
----
E
----
E
R
V
T
L
----
Y
C
G
F
D
P
T
A
D
S
L
H
I
G
H
L
A
S
I
L
T
M
R
R
F
Q
Q
A
G
H
R
P
I
A
L
V
G
G
A
T
G
L
I
G
D
P
S
G
K
K
-
S
E
R
T
L
N
A
K
E
T
V
E
A
W
S
A
R
I
K
E
Q
L
G
R
F
L
D
-----
F
E
----------
A
----
D
-
G
N
--
P
A
K
-----------
I
K
N
N
Y
D
W
I
G
P
L
D
V
I
T
F
L
R
D
V
G
K
H
F
S
V
N
Y
M
M
A
K
E
S
V
Q
S
R
I
---
E
---
T
--
G
--
I
S
F
T
E
F
S
Y
M
M
L
Q
A
Y
D
F
L
R
L
Y
E
T
E
G
C
R
L
Q
I
G
G
S
D
Q
W
G
N
I
T
A
G
L
E
L
I
R
--
K
T
K
G
-------------------
R
-
A
F
G
---------------
L
T
I
P
L
V
T
K
A
D
G
T
K
F
G
K
T
E
-
S
G
T
I
W
L
D
K
E
-
K
T
S
P
Y
E
F
Y
---
Q
F
W
I
N
T
D
D
R
D
V
I
R
Y
L
K
Y
F
T
F
L
S
K
E
E
I
E
A
L
E
Q
E
L
R
E
A
P
E
K
R
A
A
Q
K
T
L
A
E
E
V
T
K
L
V
H
G
E
E
A
L
R
Q
A
I
R
I
S
--------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
81.88
58%
-49
- C3 -
-
1TYC
-
SYY_GEOSE
A:
[1-319]
M
D
L
L
A
E
L
Q
W
R
G
L
V
N
Q
T
T
-
D
E
D
----
G
L
R
K
L
L
N
----
E
----
E
R
V
T
L
----
Y
C
G
F
D
P
T
A
D
S
L
H
I
G
H
L
A
P
I
L
T
M
R
R
F
Q
Q
A
G
H
R
P
I
A
L
V
G
G
A
T
G
L
I
G
D
P
S
G
K
K
-
S
E
R
T
L
N
A
K
E
T
V
E
A
W
S
A
R
I
K
E
Q
L
G
R
F
L
D
-----
F
E
----------
A
----
D
-
G
N
--
P
A
K
-----------
I
K
N
N
Y
D
W
I
G
P
L
D
V
I
T
F
L
R
D
V
G
K
H
F
S
V
N
Y
M
M
A
K
E
S
V
Q
S
R
I
---
E
---
T
--
G
--
I
S
F
T
E
F
S
Y
M
M
L
Q
A
Y
D
F
L
R
L
Y
E
T
E
G
C
R
L
Q
I
G
G
S
D
Q
W
G
N
I
T
A
G
L
E
L
I
R
--
K
T
K
G
-------------------
R
-
A
F
G
---------------
L
T
I
P
L
V
T
K
A
D
G
T
K
F
G
K
T
E
-
S
G
T
I
W
L
D
K
E
-
K
T
S
P
Y
E
F
Y
---
Q
F
W
I
N
T
D
D
R
D
V
I
R
Y
L
K
Y
F
T
F
L
S
K
E
E
I
E
A
L
E
Q
E
L
R
E
A
P
E
K
R
A
A
Q
K
T
L
A
E
E
V
T
K
L
V
H
G
E
E
A
L
R
Q
A
I
R
I
S
--------------------------------------------------------------------------------------------------------
22
PsiBlast_CBE
81.70
57%
-39
- C3 -
-
1VBM
1
SYY_ECOLI
B:
[1-316]
-
N
L
I
K
Q
L
Q
E
R
G
L
V
A
Q
V
T
-
D
E
E
----
A
L
A
E
R
L
A
----
Q
----
G
P
I
A
L
----
Y
C
G
F
D
P
T
A
D
S
L
H
L
G
H
L
V
P
L
L
C
L
K
R
F
Q
Q
A
G
H
K
P
V
A
L
V
G
G
A
T
G
L
I
G
D
P
S
F
K
A
-
A
E
R
K
L
N
T
E
E
T
V
Q
E
W
V
D
K
I
R
K
Q
V
A
P
F
L
D
-----
F
D
----------
C
----
G
-
E
N
--
S
A
I
-----------
A
A
N
N
Y
D
W
F
G
N
M
N
V
L
T
F
L
R
D
I
G
K
H
F
S
V
N
Q
M
I
N
K
E
A
V
K
Q
R
L
NRE
D
---
Q
--
G
--
I
S
F
T
E
F
S
Y
N
L
L
Q
G
Y
D
F
A
C
L
N
K
Q
Y
G
V
V
L
Q
I
G
G
S
D
Q
W
G
N
I
T
S
G
I
D
L
T
R
--
R
-
L
H
Q
-----------------
N
Q
-
V
F
G
---------------
L
T
V
P
L
I
T
K
A
D
G
T
K
F
G
K
T
E
-
G
G
A
V
W
L
D
P
K
-
K
T
S
P
Y
K
F
Y
---
Q
F
W
I
N
T
A
D
A
D
V
Y
R
F
L
K
F
F
T
F
M
S
I
E
E
I
N
A
L
E
E
E
D
K
N
S
G
K
A
P
R
A
Q
Y
V
L
A
E
Q
V
T
R
L
V
H
G
E
E
G
L
Q
A
A
------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
81.70
58%
-52
- C3 -
-
1TYA
1
SYY_GEOSE
E:
[1-319]
M
D
L
L
A
E
L
Q
W
R
G
L
V
N
Q
T
T
-
D
E
D
----
G
L
R
K
L
L
N
----
E
----
E
R
V
T
L
----
Y
C
G
F
D
P
T
A
D
S
L
H
I
G
H
L
A
A
I
L
T
M
R
R
F
Q
Q
A
G
H
R
P
I
A
L
V
G
G
A
T
G
L
I
G
D
P
S
G
K
K
-
S
E
R
T
L
N
A
K
E
T
V
E
A
W
S
A
R
I
K
E
Q
L
G
R
F
L
D
-----
F
E
----------
A
----
D
-
G
N
--
P
A
K
-----------
I
K
N
N
Y
D
W
I
G
P
L
D
V
I
T
F
L
R
D
V
G
K
H
F
S
V
N
Y
M
M
A
K
E
S
V
Q
S
R
I
---
E
---
T
--
G
--
I
S
F
T
E
F
S
Y
M
M
L
Q
A
Y
D
F
L
R
L
Y
E
T
E
G
C
R
L
Q
I
G
G
S
D
Q
W
G
N
I
T
A
G
L
E
L
I
R
--
K
T
K
G
-------------------
R
-
A
F
G
---------------
L
T
I
P
L
V
T
K
A
D
G
T
K
F
G
K
T
E
-
S
G
T
I
W
L
D
K
E
-
K
T
S
P
Y
E
F
Y
---
Q
F
W
I
N
T
D
D
R
D
V
I
R
Y
L
K
Y
F
T
F
L
S
K
E
E
I
E
A
L
E
Q
E
L
R
E
A
P
E
K
R
A
A
Q
K
T
L
A
E
E
V
T
K
L
V
H
G
E
E
A
L
R
Q
A
I
R
I
S
--------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
81.66
57%
-43
- C3 -
-
1X8X
1
SYY_ECOLI
A:
[5-320]
-
N
L
I
K
Q
L
Q
E
R
G
L
V
A
Q
V
T
-
D
E
E
----
A
L
A
E
R
L
A
----
Q
----
G
P
I
A
L
----
Y
C
G
F
D
P
T
A
D
S
L
H
L
G
H
L
V
P
L
L
C
L
K
R
F
Q
Q
A
G
H
K
P
V
A
L
V
G
G
A
T
G
L
I
G
D
P
S
F
K
A
-
A
E
R
K
L
N
T
E
E
T
V
Q
E
W
V
D
K
I
R
K
Q
V
A
P
F
L
D
-----
F
D
----------
C
----
G
-
E
N
--
S
A
I
-----------
A
A
N
N
Y
D
W
F
G
N
M
N
V
L
T
F
L
R
D
I
G
K
H
F
S
V
N
Q
M
I
N
K
E
A
V
K
Q
R
L
N
RE
D
---
Q
--
G
--
I
S
F
T
E
F
S
Y
N
L
L
Q
G
Y
D
F
A
C
L
N
K
Q
Y
G
V
V
L
Q
I
G
G
S
D
Q
W
G
N
I
T
S
G
I
D
L
T
R
--
R
-
L
H
Q
-----------------
N
Q
-
V
F
G
---------------
L
T
V
P
L
I
T
K
A
D
G
T
K
F
G
K
T
E
-
G
G
A
V
W
L
D
P
K
-
K
T
S
P
Y
K
F
Y
---
Q
F
W
I
N
T
A
D
A
D
V
Y
R
F
L
K
F
F
T
F
M
S
I
E
E
I
N
A
L
E
E
E
D
K
N
S
G
K
A
P
R
A
Q
Y
V
L
A
E
Q
V
T
R
L
V
H
G
E
E
G
L
Q
A
A
------------------------------------------------------------------------------------------------------------
23
PsiBlast_CBE
81.51
56%
-43
- C3 -
-
1VBN
1
SYY_ECOLI
B:
[1-316]
-
N
L
I
K
Q
L
Q
E
R
G
L
V
A
Q
V
T
-
D
E
E
----
A
L
A
E
R
L
A
----
Q
----
G
P
I
A
L
----
V
C
G
F
D
P
T
A
D
S
L
H
L
G
H
L
V
P
L
L
C
L
K
R
F
Q
Q
A
G
H
K
P
V
A
L
V
G
G
A
T
G
L
I
G
D
P
S
F
K
A
-
A
E
R
K
L
N
T
E
E
T
V
Q
E
W
V
D
K
I
R
K
Q
V
A
P
F
L
D
-----
F
D
----------
C
----
G
-
E
N
--
S
A
I
-----------
A
A
N
N
Y
D
W
F
G
N
M
N
V
L
T
F
L
R
D
I
G
K
H
F
S
V
N
Q
M
I
N
K
E
A
V
K
Q
R
L
NRE
D
---
Q
--
G
--
I
S
F
T
E
F
S
Y
N
L
L
Q
G
Y
D
F
A
C
L
N
K
Q
Y
G
V
V
L
C
I
G
G
S
D
Q
W
G
N
I
T
S
G
I
D
L
T
R
--
R
-
L
H
Q
-----------------
N
Q
-
V
F
G
---------------
L
T
V
P
L
I
T
K
A
D
G
T
K
F
G
K
T
E
-
G
G
A
V
W
L
D
P
K
-
K
T
S
P
Y
K
F
Y
---
Q
F
W
I
N
T
A
D
A
D
V
Y
R
F
L
K
F
F
T
F
M
S
I
E
E
I
N
A
L
E
E
E
D
K
N
S
G
K
A
P
R
A
Q
Y
V
L
A
E
Q
V
T
R
L
V
H
G
E
E
G
L
Q
A
A
------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
81.34
57%
-49
- C3 -
-
2TS1
-
SYY_GEOSE
A:
[1-319]
M
D
L
L
A
E
L
Q
W
R
G
L
V
N
Q
T
T
-
D
E
D
----
G
L
R
K
L
L
N
----
E
----
E
R
V
T
L
----
Y
C
G
F
D
P
T
A
D
S
L
H
I
G
H
L
A
T
I
L
T
M
R
R
F
Q
Q
A
G
H
R
P
I
A
L
V
G
G
A
T
G
L
I
G
D
P
S
G
K
K
-
S
E
R
T
L
N
A
K
E
T
V
E
A
W
S
A
R
I
K
E
Q
L
G
R
F
L
D
-----
F
E
----------
A
----
D
-
G
N
--
P
A
K
-----------
I
K
N
N
Y
D
W
I
G
P
L
D
V
I
T
F
L
R
D
V
G
K
H
F
S
V
N
Y
M
M
A
K
E
S
V
Q
S
R
I
---
E
---
T
--
G
--
I
S
F
T
E
F
S
Y
M
M
L
Q
A
Y
D
F
L
R
L
Y
E
T
E
G
C
R
L
Q
I
G
G
S
D
Q
W
G
N
I
T
A
G
L
E
L
I
R
--
K
T
K
G
-------------------
R
-
A
F
G
---------------
L
T
I
P
L
V
T
K
A
D
G
T
K
F
G
K
T
E
-
S
G
T
I
W
L
D
K
E
-
K
T
S
P
Y
E
F
Y
---
Q
F
W
I
N
T
D
D
R
D
V
I
R
Y
L
K
Y
F
T
F
L
S
K
E
E
I
E
A
L
E
Q
E
L
R
E
A
P
E
K
R
A
A
Q
K
T
L
A
E
E
V
T
K
L
V
H
G
E
E
A
L
R
Q
A
I
R
I
S
--------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
81.24
57%
-50
- C3 -
-
3TS1
1
SYY_GEOSE
A:
[1-319]
M
D
L
L
A
E
L
Q
W
R
G
L
V
N
Q
T
T
-
D
E
D
----
G
L
R
K
L
L
N
----
E
----
E
R
V
T
L
----
Y
C
G
F
D
P
T
A
D
S
L
H
I
G
H
L
A
T
I
L
T
M
R
R
F
Q
Q
A
G
H
R
P
I
A
L
V
G
G
A
T
G
L
I
G
D
P
S
G
K
K
-
S
E
R
T
L
N
A
K
E
T
V
E
A
W
S
A
R
I
K
E
Q
L
G
R
F
L
D
-----
F
E
----------
A
----
D
-
G
N
--
P
A
K
-----------
I
K
N
N
Y
D
W
I
G
P
L
D
V
I
T
F
L
R
D
V
G
K
H
F
S
V
N
Y
M
M
A
K
E
S
V
Q
S
R
I
---
E
---
T
--
G
--
I
S
F
T
E
F
S
Y
M
M
L
Q
A
Y
D
F
L
R
L
Y
E
T
E
G
C
R
L
Q
I
G
G
S
D
Q
W
G
N
I
T
A
G
L
E
L
I
R
--
K
T
K
G
-------------------
R
-
A
F
G
---------------
L
T
I
P
L
V
T
K
A
D
G
T
K
F
G
K
T
E
-
S
G
T
I
W
L
D
K
E
-
K
T
S
P
Y
E
F
Y
---
Q
F
W
I
N
T
D
D
R
D
V
I
R
Y
L
K
Y
F
T
F
L
S
K
E
E
I
E
A
L
E
Q
E
L
R
E
A
P
E
K
R
A
A
Q
K
T
L
A
E
E
V
T
K
L
V
H
G
E
E
A
L
R
Q
A
I
R
I
S
--------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
80.89
56%
-46
- C3 -
-
2YXN
1
SYY_ECOLI
A:
[5-320]
-
N
L
I
K
Q
L
Q
E
R
G
L
V
A
Q
V
T
-
D
E
E
----
A
L
A
E
R
L
A
----
Q
----
G
P
I
A
L
----
V
C
G
F
D
P
T
A
D
S
L
H
L
G
H
L
V
P
L
L
C
L
K
R
F
Q
Q
A
G
H
K
P
V
A
L
V
G
G
A
T
G
L
I
G
D
P
S
F
K
A
-
A
E
R
K
L
N
T
E
E
T
V
Q
E
W
V
D
K
I
R
K
Q
V
A
P
F
L
D
-----
F
D
----------
C
----
G
-
E
N
--
S
A
I
-----------
A
A
N
N
Y
D
W
F
G
N
M
N
V
L
T
F
L
R
D
I
G
K
H
F
S
V
N
Q
M
I
N
K
E
A
V
K
Q
R
L
N
RE
D
---
Q
--
G
--
I
S
F
T
E
F
S
Y
N
L
L
Q
G
Y
D
F
A
C
L
N
K
Q
Y
G
V
V
L
C
I
G
G
S
D
Q
W
G
N
I
T
S
G
I
D
L
T
R
--
R
-
L
H
Q
-----------------
N
Q
-
V
F
G
---------------
L
T
V
P
L
I
T
K
A
D
G
T
K
F
G
K
T
E
-
G
G
A
V
W
L
D
P
K
-
K
T
S
P
Y
K
F
Y
---
Q
F
W
I
N
T
A
D
A
D
V
Y
R
F
L
K
F
F
T
F
M
S
I
E
E
I
N
A
L
E
E
E
D
K
N
S
G
K
A
P
R
A
Q
Y
V
L
A
E
Q
V
T
R
L
V
H
G
E
E
G
L
Q
A
A
------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
80.47
58%
-49
- C3 -
-
4TS1
1
SYY_GEOSE
A:
[1-316]
M
D
L
L
A
E
L
Q
W
R
G
L
V
N
Q
T
T
-
D
E
D
----
G
L
R
K
L
L
N
----
E
----
E
R
V
T
L
----
Y
C
G
F
D
P
T
A
D
S
L
H
I
G
H
L
A
T
I
L
T
M
R
R
F
Q
Q
A
G
H
R
P
I
A
L
V
G
G
A
T
G
L
I
G
D
P
S
G
K
K
-
S
E
R
T
L
N
A
K
E
T
V
E
A
W
S
A
R
I
K
E
Q
L
G
R
F
L
D
-----
F
E
----------
A
----
D
-
G
N
--
P
A
K
-----------
I
K
N
N
Y
D
W
I
G
P
L
D
V
I
T
F
L
R
D
V
G
K
H
F
S
V
N
Y
M
M
A
K
E
S
V
Q
S
R
I
---
E
---
T
--
G
--
I
S
F
T
E
F
S
Y
M
M
L
Q
A
Y
D
F
L
R
L
Y
E
T
E
G
C
R
L
Q
I
G
G
S
D
Q
W
G
N
I
T
A
G
L
E
L
I
R
--
K
T
K
G
-------------------
R
-
A
F
G
---------------
L
T
I
P
L
V
T
K
A
D
G
T
K
F
G
K
T
E
-
S
G
T
I
W
L
D
K
E
-
K
T
S
P
Y
E
F
Y
---
Q
F
W
I
N
T
D
D
R
D
V
I
R
Y
L
K
Y
F
T
F
L
S
K
E
E
I
E
A
L
E
Q
E
L
R
E
A
P
E
K
R
A
A
Q
K
T
L
A
E
E
V
T
K
L
V
H
G
E
E
A
L
R
Q
A
I
-----------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
80.23
53%
-48
- C3 -
-
1JIK
-
SYY_STAAE
A:
[5-320]
--
L
I
E
D
L
K
W
R
G
L
I
Y
Q
Q
T
-
D
E
Q
----
G
I
E
D
L
L
N
----
K
----
E
Q
V
T
L
----
Y
C
G
A
D
P
T
A
D
S
L
H
I
G
H
L
L
P
F
L
T
L
R
R
F
Q
E
H
G
H
R
P
I
V
L
I
G
G
G
T
G
M
I
G
D
P
S
G
K
S
-
E
E
R
V
L
Q
T
E
E
Q
V
D
K
N
I
E
G
I
S
K
Q
M
H
N
I
F
E
-----
F
-----------
G
----
T
-
D
H
--
G
A
V
-----------
L
V
N
N
R
D
W
L
G
Q
I
S
L
I
S
F
L
R
D
Y
G
K
H
V
G
V
N
Y
M
L
G
K
D
S
I
Q
S
R
L
---
E
---
H
--
G
--
I
S
Y
T
E
F
T
Y
T
I
L
Q
A
I
D
F
G
H
L
N
R
E
L
N
C
K
I
Q
V
G
G
S
D
Q
W
G
N
I
T
S
G
I
E
L
M
R
--
R
-
M
Y
G
-----------------
Q
T
D
A
Y
G
---------------
L
T
I
P
L
V
T
K
S
D
G
K
K
F
G
K
S
E
-
S
G
A
V
W
L
D
A
E
-
K
T
S
P
Y
E
F
Y
---
Q
F
W
I
N
Q
S
D
E
D
V
I
K
F
L
K
Y
F
T
F
L
G
K
E
E
I
D
R
L
E
Q
S
K
N
E
A
P
H
L
R
E
A
Q
K
T
L
A
E
E
V
T
K
F
I
H
G
E
D
A
L
N
D
A
I
R
I
S
--------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
79.88
56%
-45
- C3 -
-
1WQ4
1
SYY_ECOLI
A:
[4-319]
-
N
L
I
K
Q
L
Q
E
R
G
L
V
A
Q
V
T
-
D
E
E
----
A
L
A
E
R
L
A
----
Q
----
G
P
I
A
L
----
V
C
G
F
D
P
T
A
D
S
L
H
L
G
H
L
V
P
L
L
C
L
K
R
F
Q
Q
A
G
H
K
P
V
A
L
V
G
G
A
T
G
L
I
G
D
P
S
F
K
A
-
A
E
R
K
L
N
T
E
E
T
V
Q
E
W
V
D
K
I
R
K
Q
V
A
P
F
L
D
-----
F
D
----------
C
----
G
-
E
N
--
S
A
I
-----------
A
A
N
N
Y
D
W
F
G
N
M
N
V
L
T
F
L
R
D
I
G
K
H
F
S
V
N
Q
M
I
N
K
E
A
V
K
Q
R
L
N
RE
D
---
Q
--
G
--
I
S
F
T
E
F
S
Y
N
L
L
Q
G
Y
D
F
A
C
L
N
K
Q
Y
G
V
V
L
C
I
G
G
S
D
Q
W
G
N
I
T
S
G
I
D
L
T
R
--
R
-
L
H
Q
-----------------
N
Q
-
V
F
G
---------------
L
T
V
P
L
I
T
K
A
D
G
T
K
F
G
K
T
E
-
G
G
A
V
W
L
D
P
K
-
K
T
S
P
Y
K
F
Y
---
Q
F
W
I
N
T
A
D
A
D
V
Y
R
F
L
K
F
F
T
F
M
S
I
E
E
I
N
A
L
E
E
E
D
K
N
S
G
K
A
P
R
A
Q
Y
V
L
A
E
Q
V
T
R
L
V
H
G
E
E
G
L
Q
A
A
------------------------------------------------------------------------------------------------------------
21
PsiBlast_CBE
79.49
58%
-49
- C3 -
-
4TS1
1
SYY_GEOSE
B:
[1-313]
M
D
L
L
A
E
L
Q
W
R
G
L
V
N
Q
T
T
-
D
E
D
----
G
L
R
K
L
L
N
----
E
----
E
R
V
T
L
----
Y
C
G
F
D
P
T
A
D
S
L
H
I
G
H
L
A
T
I
L
T
M
R
R
F
Q
Q
A
G
H
R
P
I
A
L
V
G
G
A
T
G
L
I
G
D
P
S
G
K
K
-
S
E
R
T
L
N
A
K
E
T
V
E
A
W
S
A
R
I
K
E
Q
L
G
R
F
L
D
-----
F
E
----------
A
----
D
-
G
N
--
P
A
K
-----------
I
K
N
N
Y
D
W
I
G
P
L
D
V
I
T
F
L
R
D
V
G
K
H
F
S
V
N
Y
M
M
A
K
E
S
V
Q
S
R
I
---
E
---
T
--
G
--
I
S
F
T
E
F
S
Y
M
M
L
Q
A
Y
D
F
L
R
L
Y
E
T
E
G
C
R
L
Q
I
G
G
S
D
Q
W
G
N
I
T
A
G
L
E
L
I
R
--
K
T
K
G
-------------------
R
-
A
F
G
---------------
L
T
I
P
L
V
T
K
A
D
G
T
K
F
G
K
T
E
-
S
G
T
I
W
L
D
K
E
-
K
T
S
P
Y
E
F
Y
---
Q
F
W
I
N
T
D
D
R
D
V
I
R
Y
L
K
Y
F
T
F
L
S
K
E
E
I
E
A
L
E
Q
E
L
R
E
A
P
E
K
R
A
A
Q
K
T
L
A
E
E
V
T
K
L
V
H
G
E
E
A
L
R
--------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
78.70
57%
-36
- C3 -
-
1VBM
1
SYY_ECOLI
A:
[1-316]
-
N
L
I
K
Q
L
Q
E
R
G
L
V
A
Q
V
T
-
D
E
E
----
A
L
A
E
R
L
A
----
Q
----
G
P
I
A
L
----
Y
C
G
F
D
P
T
A
D
S
L
H
L
G
H
L
V
P
L
L
C
L
K
R
F
Q
Q
A
G
H
K
P
V
A
L
V
G
G
A
T
G
L
I
G
D
P
S
F
K
A
-
A
E
R
K
L
N
T
E
E
T
V
Q
E
W
V
D
K
I
R
K
Q
V
A
P
F
L
D
-----
F
D
----------
C
----
G
-
E
N
--
S
A
I
-----------
A
A
N
N
Y
D
W
F
G
N
M
N
V
L
T
F
L
R
D
I
G
K
H
F
S
V
N
Q
M
I
N
K
E
A
V
K
Q
R
L
NRE
D
---
Q
--
G
--
I
S
F
T
E
F
S
Y
N
L
L
Q
G
Y
D
F
A
C
L
N
K
Q
Y
G
V
V
L
Q
I
G
G
S
D
Q
W
G
N
I
T
S
G
I
D
L
T
R
--
R
-
L
H
Q
-----------------
N
Q
-
V
F
G
---------------
L
T
V
P
L
I
T
K
A
D
G
T
K
F
G
K
T
E
-
G
G
A
V
W
L
D
P
K
-
K
T
S
P
Y
K
F
Y
---
Q
F
W
I
N
T
A
D
A
D
V
Y
R
F
L
K
F
F
T
F
M
S
I
E
E
I
N
A
L
E
E
E
D
K
N
S
G
K
A
P
R
A
Q
Y
V
L
A
E
Q
V
T
R
L
V
H
G
E
E
G
L
Q
A
A
------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
78.47
56%
-42
- C3 -
-
1VBN
1
SYY_ECOLI
A:
[1-316]
-
N
L
I
K
Q
L
Q
E
R
G
L
V
A
Q
V
T
-
D
E
E
----
A
L
A
E
R
L
A
----
Q
----
G
P
I
A
L
----
V
C
G
F
D
P
T
A
D
S
L
H
L
G
H
L
V
P
L
L
C
L
K
R
F
Q
Q
A
G
H
K
P
V
A
L
V
G
G
A
T
G
L
I
G
D
P
S
F
K
A
-
A
E
R
K
L
N
T
E
E
T
V
Q
E
W
V
D
K
I
R
K
Q
V
A
P
F
L
D
-----
F
D
----------
C
----
G
-
E
N
--
S
A
I
-----------
A
A
N
N
Y
D
W
F
G
N
M
N
V
L
T
F
L
R
D
I
G
K
H
F
S
V
N
Q
M
I
N
K
E
A
V
K
Q
R
L
N
RE
D
---
Q
--
G
--
I
S
F
T
E
F
S
Y
N
L
L
Q
G
Y
D
F
A
C
L
N
K
Q
Y
G
V
V
L
C
I
G
G
S
D
Q
W
G
N
I
T
S
G
I
D
L
T
R
--
R
-
L
H
Q
-----------------
N
Q
-
V
F
G
---------------
L
T
V
P
L
I
T
K
A
D
G
T
K
F
G
K
T
E
-
G
G
A
V
W
L
D
P
K
-
K
T
S
P
Y
K
F
Y
---
Q
F
W
I
N
T
A
D
A
D
V
Y
R
F
L
K
F
F
T
F
M
S
I
E
E
I
N
A
L
E
E
E
D
K
N
S
G
K
A
P
R
A
Q
Y
V
L
A
E
Q
V
T
R
L
V
H
G
E
E
G
L
Q
A
A
------------------------------------------------------------------------------------------------------------
181
HHSearch
76.58
55%
-0
- C3 -
-
2YXN
1
SYY_ECOLI
A:
[5-322]
-
N
L
I
K
Q
L
Q
E
R
G
L
V
A
Q
V
T
-
D
E
E
----
A
L
A
E
R
L
A
----
Q
----
G
P
I
A
L
----
V
C
G
F
D
P
T
A
D
S
L
H
L
G
H
L
V
P
L
L
C
L
K
R
F
Q
Q
A
G
H
K
P
V
A
L
V
G
G
A
T
G
L
I
G
D
P
S
F
K
A
-
A
E
R
K
L
N
T
E
E
T
V
Q
E
W
V
D
K
I
R
K
Q
V
A
P
--
F
-----
L
D
----------
F
----
D
-
C
G
EN
S
A
I
-----------
A
A
N
N
Y
D
W
F
G
N
M
N
V
L
T
F
L
R
D
I
G
K
H
F
S
V
N
Q
M
I
N
K
E
A
V
K
Q
R
L
---
N
RED
Q
--
G
--
I
S
F
T
E
F
S
Y
N
L
L
Q
G
Y
D
F
A
C
L
N
K
Q
Y
G
V
V
L
C
I
G
G
S
D
Q
W
G
N
I
T
S
G
I
D
L
T
R
--
R
-
L
H
Q
-----------------
N
Q
-
V
F
G
---------------
L
T
V
P
L
I
T
K
A
D
G
T
K
F
G
K
T
E
-
G
G
A
V
W
L
D
P
K
-
K
T
S
P
Y
K
F
Y
---
Q
F
W
I
N
T
A
D
A
D
V
Y
R
F
L
K
F
F
T
F
M
S
I
E
E
I
N
A
L
E
E
E
D
K
N
S
G
K
A
P
R
A
Q
Y
V
L
A
E
Q
V
T
R
L
V
H
G
E
E
G
L
Q
A
A
K
R
----------------------------------------------------------------------------------------------------------
180
HHSearch
75.96
56%
3
* C3 *
-
1VBM
1
SYY_ECOLI
A:
[1-318]
-
N
L
I
K
Q
L
Q
E
R
G
L
V
A
Q
V
T
-
D
E
E
----
A
L
A
E
R
L
A
----
Q
----
G
P
I
A
L
----
Y
C
G
F
D
P
T
A
D
S
L
H
L
G
H
L
V
P
L
L
C
L
K
R
F
Q
Q
A
G
H
K
P
V
A
L
V
G
G
A
T
G
L
I
G
D
P
S
F
K
A
-
A
E
R
K
L
N
T
E
E
T
V
Q
E
W
V
D
K
I
R
K
Q
V
A
P
--
F
-----
L
D
----------
F
----
D
-
C
G
EN
S
A
I
-----------
A
A
N
N
Y
D
W
F
G
N
M
N
V
L
T
F
L
R
D
I
G
K
H
F
S
V
N
Q
M
I
N
K
E
A
V
K
Q
R
L
---
N
RED
Q
--
G
--
I
S
F
T
E
F
S
Y
N
L
L
Q
G
Y
D
F
A
C
L
N
K
Q
Y
G
V
V
L
Q
I
G
G
S
D
Q
W
G
N
I
T
S
G
I
D
L
T
R
--
R
-
L
H
Q
-----------------
N
Q
-
V
F
G
---------------
L
T
V
P
L
I
T
K
A
D
G
T
K
F
G
K
T
E
-
G
G
A
V
W
L
D
P
K
-
K
T
S
P
Y
K
F
Y
---
Q
F
W
I
N
T
A
D
A
D
V
Y
R
F
L
K
F
F
T
F
M
S
I
E
E
I
N
A
L
E
E
E
D
K
N
S
G
K
A
P
R
A
Q
Y
V
L
A
E
Q
V
T
R
L
V
H
G
E
E
G
L
Q
A
A
K
R
----------------------------------------------------------------------------------------------------------
177
HHSearch
71.26
40%
-9
- C3 -
-
2PID
1
SYYM_HUMAN
B:
[10-346]
-
G
L
L
A
A
Q
K
A
R
G
L
F
K
D
F
F
-
P
E
T
GTKI
E
L
P
E
L
F
D
RGTA
S
----
F
P
Q
T
I
----
Y
C
G
F
D
P
T
A
D
S
L
H
V
G
H
L
L
A
L
L
G
L
F
H
L
Q
R
A
G
H
N
V
I
A
L
V
G
G
A
T
A
R
L
G
D
P
S
G
R
T
-
K
E
R
E
A
L
E
T
E
R
V
R
A
N
A
R
A
L
R
L
G
L
E
A
L
A
A
-----
N
H
Q
Q
L
-------
F
TDG
R
S
-
W
G
--
S
F
T
-----------
V
L
D
N
S
A
W
Y
Q
K
Q
H
L
V
D
F
L
A
A
V
G
G
H
F
R
M
G
T
L
L
S
R
Q
S
V
Q
L
R
L
---
K
SP-
E
--
G
--
M
S
L
A
E
F
F
Y
Q
V
L
Q
A
Y
D
F
Y
Y
L
F
Q
R
Y
G
C
R
V
Q
L
G
G
S
D
Q
L
G
N
I
M
S
G
Y
E
F
I
N
--
K
-
L
T
G
-----------------
E
D
-
V
F
G
---------------
I
T
V
P
L
I
T
--------------
A
V
W
L
N
-
R
D
K
T
S
P
F
E
L
Y
---
Q
F
F
V
R
Q
P
D
D
S
V
E
R
Y
L
K
L
F
T
F
L
P
L
P
E
I
D
H
I
M
Q
L
H
V
K
E
P
E
R
R
G
P
Q
K
R
L
A
A
E
V
T
K
L
V
H
G
R
E
G
L
D
S
A
K
R
C
T
Q
A
L
-----------------------------------------------------------------------------------------------------
174
HHSearch
69.43
35%
6
- C3 -
-
4OJM
1
SYYM_NEUCR
X:
[35-389]
-
N
T
W
D
L
F
E
E
R
G
Y
V
K
D
T
A
-
G
T
K
E---
H
I
A
E
L
M
R
----
T
----
R
R
I
G
A
----
Y
V
G
I
D
P
T
A
P
S
L
H
V
G
H
L
L
P
L
M
P
L
F
W
M
Y
L
E
G
Y
K
A
F
T
L
I
G
G
S
T
A
K
I
G
D
P
T
G
---------
S
S
S
D
A
T
M
N
M
T
K
I
H
Y
Q
L
K
K
L
W
E
-----
N
V
DTQMRARGYE
A
----
D
W
A
R
--
K
R
G
-----------
I
V
N
N
N
H
W
W
N
K
Q
P
M
L
E
V
L
R
R
V
G
H
A
L
R
I
G
P
M
L
S
R
D
T
V
K
N
K
M
---
T
QG-
D
--
G
--
V
S
F
A
E
F
T
Y
P
I
M
Q
G
W
D
W
F
E
L
F
Y
Q
Q
G
V
Q
M
Q
I
G
G
S
D
Q
Y
G
N
I
I
S
G
L
E
V
V
K
--
A
-
A
R
E
SEPDPQERKYVTPKTAL
D
E
-
C
V
G
---------------
F
T
V
P
L
L
T
D
S
S
G
A
K
F
G
K
S
A
-
G
N
A
I
W
L
D
P
Y
-
Q
T
S
V
F
D
F
Y
---
G
Y
F
V
R
R
S
D
Q
E
V
E
N
L
L
K
L
F
T
F
M
P
I
S
E
I
T
K
T
M
E
E
H
I
K
D
P
S
K
R
V
A
Q
H
T
L
A
R
E
V
V
T
L
V
H
G
K
Q
E
A
S
A
A
E
D
Q
H
R
M
M
Y
T
-
G
Q
------------------------------------------------------------------------------------------------
178
HHSearch
68.08
40%
7
- C3 -
-
2PID
1
SYYM_HUMAN
A:
[10-346]
-
G
L
L
A
A
Q
K
A
R
G
L
F
K
D
F
F
-
P
E
T
GTKI
E
L
P
E
L
F
-----------
P
Q
T
I
----
Y
C
G
F
D
P
T
A
D
S
L
H
V
G
H
L
L
A
L
L
G
L
F
H
L
Q
R
A
G
H
N
V
I
A
L
V
G
G
A
T
A
R
L
G
D
P
S
G
R
T
-
K
E
R
E
A
L
E
T
E
R
V
R
A
N
A
R
A
L
R
L
G
L
E
A
L
A
A
-----
N
H
Q
Q
L-------
F
TDGR
S
-
W
G
--
S
F
T
-----------
V
L
D
N
S
A
W
Y
Q
K
Q
H
L
V
D
F
L
A
A
V
G
G
H
F
R
M
G
T
L
L
S
R
Q
S
V
Q
L
R
L
---
K
SP-
E
--
G
--
M
S
L
A
E
F
F
Y
Q
V
L
Q
A
Y
D
F
Y
Y
L
F
Q
R
Y
G
C
R
V
Q
L
G
G
S
D
Q
L
G
N
I
M
S
G
Y
E
F
I
N
--
K
-
L
T
G
-----------------
E
D
-
V
F
G
---------------
I
T
V
P
L
I
T
--------------
A
V
W
L
N
-
R
D
K
T
S
P
F
E
L
Y
---
Q
F
F
V
R
Q
P
D
D
S
V
E
R
Y
L
K
L
F
T
F
L
P
L
P
E
I
D
H
I
M
Q
L
H
V
K
E
P
E
R
R
G
P
Q
K
R
L
A
A
E
V
T
K
L
V
H
G
R
E
G
L
D
S
A
K
R
C
T
Q
A
L
-----------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
66.76
40%
14
- C3 -
-
2PID
1
SYYM_HUMAN
A:
[16-346]
-------
K
A
R
G
L
F
K
D
F
F
-
P
E
T
----
G
T
K
I
E
L
P
----
E
LF-------P
Q
T
I
Y
C
G
F
D
P
T
A
D
S
L
H
V
G
H
L
L
A
L
L
G
L
F
H
L
Q
R
A
G
H
N
V
I
A
L
V
G
G
A
T
A
R
L
G
D
P
S
G
R
T
-
K
E
R
E
A
L
E
T
E
R
V
R
A
N
A
R
A
L
R
L
G
L
E
A
L
A
A
N
H
Q
Q
L
F
T
----------
D
----
G
-
R
S
W
G
S
F
T
-----------
V
L
D
N
S
A
W
Y
Q
K
Q
H
L
V
D
F
L
A
A
V
G
G
H
F
R
M
G
T
L
L
S
R
Q
S
V
Q
L
R
L
---
K
---
S
PE
G
--
M
S
L
A
E
F
F
Y
Q
V
L
Q
A
Y
D
F
Y
Y
L
F
Q
R
Y
G
C
R
V
Q
L
G
G
S
D
Q
L
G
N
I
M
S
G
Y
E
F
I
N
--
K
-
L
T
G
-----------------
E
D
-
V
F
G
---------------
I
T
V
P
L
I
T
--------------
A
V
W
L
N
R
D
-
K
T
S
P
F
E
L
Y
---
Q
F
F
V
R
Q
P
D
D
S
V
E
R
Y
L
K
L
F
T
F
L
P
L
P
E
I
D
H
I
M
Q
L
H
V
K
E
P
E
R
R
G
P
Q
K
R
L
A
A
E
V
T
K
L
V
H
G
R
E
G
L
D
S
A
K
R
C
T
Q
A
L
-----------------------------------------------------------------------------------------------------
25
PsiBlast_CBE
66.66
40%
15
- C3 -
-
2PID
1
SYYM_HUMAN
B:
[16-346]
-------
K
A
R
G
L
F
K
D
F
F
-
P
E
T
----
G
T
K
I
E
L
P
----
E
L
F
DR
G
T
A
S
F
P
Q
T
I
Y
C
G
F
D
P
T
A
D
S
L
H
V
G
H
L
L
A
L
L
G
L
F
H
L
Q
R
A
G
H
N
V
I
A
L
V
G
G
A
T
A
R
L
G
D
P
S
G
R
T
-
K
E
R
E
A
L
E
T
E
R
V
R
A
N
A
R
A
L
R
L
G
L
E
A
L
A
A
N
H
Q
Q
L
F
T
----------
D
----
G
-
R
S
W
G
S
F
T
-----------
V
L
D
N
S
A
W
Y
Q
K
Q
H
L
V
D
F
L
A
A
V
G
G
H
F
R
M
G
T
L
L
S
R
Q
S
V
Q
L
R
L
---
K
---
S
PE
G
--
M
S
L
A
E
F
F
Y
Q
V
L
Q
A
Y
D
F
Y
Y
L
F
Q
R
Y
G
C
R
V
Q
L
G
G
S
D
Q
L
G
N
I
M
S
G
Y
E
F
I
N
--
K
-
L
T
G
-----------------
E
D
-
V
F
G
---------------
I
T
V
P
L
I
T
--------------
A
V
W
L
N
R
D
-
K
T
S
P
F
E
L
Y
---
Q
F
F
V
R
Q
P
D
D
S
V
E
R
Y
L
K
L
F
T
F
L
P
L
P
E
I
D
H
I
M
Q
L
H
V
K
E
P
E
R
R
G
P
Q
K
R
L
A
A
E
V
T
K
L
V
H
G
R
E
G
L
D
S
A
K
R
C
T
Q
A
L
-----------------------------------------------------------------------------------------------------
26
PsiBlast_CBE
66.19
33%
7
- C3 -
-
4OJM
1
SYYM_NEUCR
X:
[37-390]
---
W
D
L
F
E
E
R
G
Y
V
K
D
T
A
G
T
K
E
----
H
I
A
E
L
M
R
----
T
----
R
R
I
G
A
----
Y
V
G
I
D
P
T
A
P
S
L
H
V
G
H
L
L
P
L
M
P
L
F
W
M
Y
L
E
G
Y
K
A
F
T
L
I
G
G
S
T
A
K
I
G
D
P
T
G
--------
S
S
S
D
A
T
M
N
M
T
K
-
I
H
Y
Q
L
K
K
L
W
E
-----
N
V
----------
D
----
T
-
Q
M
--
R
A
R
GYEADWARKRG
I
V
N
N
N
H
W
W
N
K
Q
P
M
L
E
V
L
R
R
V
G
H
A
L
R
I
G
P
M
L
S
R
D
T
V
K
N
K
M
---
T
---
Q
--
G
DG
V
S
F
A
E
F
T
Y
P
I
M
Q
G
W
D
W
F
E
L
F
Y
Q
Q
G
V
Q
M
Q
I
G
G
S
D
Q
Y
G
N
I
I
S
G
L
E
V
V
K
AA
R
-
E
S
E
-----------------
P
D
-
P
Q
E
RKYVTPKTALDECVG
F
T
V
P
L
L
T
D
S
S
G
A
K
F
G
K
S
A
-
G
N
A
I
W
L
D
P
Y
-
Q
T
S
V
F
D
F
Y
---
G
Y
F
V
R
R
S
D
Q
E
V
E
N
L
L
K
L
F
T
F
M
P
I
S
E
I
T
K
T
M
E
E
H
I
K
D
P
S
K
R
V
A
Q
H
T
L
A
R
E
V
V
T
L
V
H
G
K
Q
E
A
S
A
A
E
D
Q
H
R
M
M
Y
T
-
G
Q
-
M
----------------------------------------------------------------------------------------------
27
PsiBlast_CBE
65.53
33%
5
- C3 -
-
1Y42
1
SYYM_NEUCR
X:
[37-388]
---
W
D
L
F
E
E
R
G
Y
V
K
D
T
A
G
T
K
E
----
H
I
A
E
L
M
R
----
T
----
R
R
I
G
A
----
Y
V
G
I
D
P
T
A
P
S
L
H
V
G
H
L
L
P
L
M
P
L
F
W
M
Y
L
E
G
Y
K
A
F
T
L
I
G
G
S
T
A
K
I
G
D
P
T
G
-----------
D
A
T
M
N
M
T
K
-
I
H
Y
Q
L
K
K
L
W
E
-----
N
V
----------
D
----
T
-
Q
M
--
R
A
R
GYEADWARKRG
I
V
N
N
N
H
W
W
N
K
Q
P
M
L
E
V
L
R
R
V
G
H
A
L
R
I
G
P
M
L
S
R
D
T
V
K
N
K
M
---
T
---
Q
--
G
DG
V
S
F
A
E
F
T
Y
P
I
M
Q
G
W
D
W
F
E
L
F
Y
Q
Q
G
V
Q
M
Q
I
G
G
S
D
Q
Y
G
N
I
I
S
G
L
E
V
V
K
AA
R
-
E
S
E
-----------------
P
D
-
P
Q
E
RKYVTPKTALDECVG
F
T
V
P
L
L
T
D
S
S
G
A
K
F
G
K
S
A
-
G
N
A
I
W
L
D
P
Y
-
Q
T
S
V
F
D
F
Y
---
G
Y
F
V
R
R
S
D
Q
E
V
E
N
L
L
K
L
F
T
F
M
P
I
S
E
I
T
K
T
M
E
E
H
I
K
D
P
S
K
R
V
A
Q
H
T
L
A
R
E
V
V
T
L
V
H
G
K
Q
E
A
S
A
A
E
D
Q
H
R
M
M
Y
T
-
G
-------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
64.64
40%
11
- C3 -
-
3ZXI
1
SYYM_HUMAN
A:
[16-346]
-------
K
A
R
G
L
F
K
D
F
F
-
P
---------------------------P
Q
T
I
Y
C
G
F
D
P
T
A
D
S
L
H
V
G
H
L
L
A
L
L
G
L
F
H
L
Q
R
A
G
H
N
V
I
A
L
V
G
G
A
T
A
R
L
G
D
P
S
G
R
T
-
K
E
R
E
A
L
E
T
E
R
V
R
A
N
A
R
A
L
R
L
G
L
E
A
L
A
A
N
H
Q
Q
L
F
T
----------
D
----
G
-
R
S
W
G
S
F
T
-----------
V
L
D
N
S
A
W
Y
Q
K
Q
H
L
V
D
F
L
A
A
V
G
G
H
F
R
M
G
T
L
L
S
R
Q
S
V
Q
L
R
L
---
K
---
S
PE
G
--
M
S
L
A
E
F
F
Y
Q
V
L
Q
A
Y
D
F
Y
Y
L
F
Q
R
Y
G
C
R
V
Q
L
G
G
S
D
Q
L
G
N
I
M
S
G
Y
E
F
I
N
--
K
-
L
T
G
-----------------
E
D
-
V
F
G
---------------
I
T
V
P
L
I
T
--------------
A
V
W
L
N
R
D
-
K
T
S
P
F
E
L
Y
---
Q
F
F
V
R
Q
P
D
D
S
V
E
R
Y
L
K
L
F
T
F
L
P
L
P
E
I
D
H
I
M
Q
L
H
V
K
E
P
E
R
R
G
P
Q
K
R
L
A
A
E
V
T
K
L
V
H
G
R
E
G
L
D
S
A
K
R
C
T
Q
A
L
-----------------------------------------------------------------------------------------------------
24
PsiBlast_CBE
64.56
40%
13
- C3 -
-
3ZXI
1
SYYM_HUMAN
B:
[16-346]
-------
K
A
R
G
L
F
K
D
F
F
-
P
---------------------------PQTI
Y
C
G
F
D
P
T
A
D
S
L
H
V
G
H
L
L
A
L
L
G
L
F
H
L
Q
R
A
G
H
N
V
I
A
L
V
G
G
A
T
A
R
L
G
D
P
S
G
R
T
-
K
E
R
E
A
L
E
T
E
R
V
R
A
N
A
R
A
L
R
L
G
L
E
A
L
A
A
NHQQL
F
T
----------
D
----
G
-
R
S
WG
S
F
T
-----------
V
L
D
N
S
A
W
Y
Q
K
Q
H
L
V
D
F
L
A
A
V
G
G
H
F
R
M
G
T
L
L
S
R
Q
S
V
Q
L
R
L
---
K
---
S
PE
G
--
M
S
L
A
E
F
F
Y
Q
V
L
Q
A
Y
D
F
Y
Y
L
F
Q
R
Y
G
C
R
V
Q
L
G
G
S
D
Q
L
G
N
I
M
S
G
Y
E
F
I
N
--
K
-
L
T
G
-----------------
E
D
-
V
F
G
---------------
I
T
V
P
L
I
T
--------------
A
V
W
L
N
R
D
-
K
T
S
P
F
E
L
Y
---
Q
F
F
V
R
Q
P
D
D
S
V
E
R
Y
L
K
L
F
T
F
L
P
L
P
E
I
D
H
I
M
Q
L
H
V
K
E
P
E
R
R
G
P
Q
K
R
L
A
A
E
V
T
K
L
V
H
G
R
E
G
L
D
S
A
K
R
C
T
Q
A
L
-----------------------------------------------------------------------------------------------------