@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : spr2025: (2018-01-25 )
MGIALENVNFIYQEGTPLASAALSDVSLTIEDGSYTALIGHTGSGKSTILQLLNGLLVPSQGSVRVFDTLITSTSKNKDIRQIRKQVGLVFQFAENQIFEETVLKDVAFGPQNFGVSEEDAVKTAREKLALVGIDESLFDRSPFELSGGQMRRVAIAGILAMEPSILVLDEPTAGLDPLGRKELMTLFKKLHQSGMTIVLVTHLMDDVAEYANQVYVMEKGRLVKGGKPSDVFQDVVFMEEVQLGVPKITAFCKRLADRGVSFKRLPIKIEEFKESLNG
Atome Classification :
(43 SA)
.........10........20........30........40........50........60..----------......70........80....-....90........100........110...----.-..-------------.-.120......------.130..-.-.---...140.......150.......160.......170.......180....-...190-.-.-.....200.......210......------.220----.......230.......240.......250.......260.......270.----......
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
M
G
I
A
L
EN
V
N
F
I
Y
QEGTP
L
A
S
AALS
D
V
S
L
T
IEDG
S
Y
T
A
L
I
GHTGS
G
K
S
T
I
L
Q
L
L
N
G
LLVPSQG
S
----------
V
R
V
F
D
T
L
ITSTSK
N
K
D
I
R
Q
I
R
K
-QV
G
L
V
F
Q
FAEN
Q
I
F
E
E
-
T
V
L
K
D
VAFGP-QNF----G-V
S
-------------
E
-
E
D
A
V
K
T
A
R
E
K
------
L
A
L
V
GI-
D
-
E
---
S
L
FDRSPFELSGG
Q
M
R
R
V
A
I
A
G
I
LAME
P
S
I
L
V
L
DEPTAGLDPL
G
R
K
E
L
M
T
-
L
F
K
K
L
H
-Q-S-G
M
T
I
V
L
V
T
H
L
M
D
D
V
A
E
Y
A
N
Q
V
Y
V
M
------EK
G
R
----LVKGG
K
P
S
D
V
F
Q
D
V
V
F
M
E
E
V
QLG
V
P
K
I
T
A
F
C
K
R
L
A
DRGVSFKRLPI
K
I
E
E
F
----
K
E
SLNG
22
PsiBlast_CBE
82.82
46%
-116
- C1 -
-
5D3M
2
ECFA2_LACDA
F:
[2-282]
-
A
I
K
F
E
N
V
S
Y
V
Y
S
P
G
S
P
L
E
A
I
G
L
D
Q
L
N
F
S
L
E
E
G
K
F
I
A
L
V
G
H
T
G
S
G
K
S
T
L
M
Q
H
F
N
A
L
L
K
P
T
S
G
K
----------
I
E
I
A
G
Y
T
I
T
P
E
T
G
N
K
G
L
K
D
L
R
R
-
K
V
S
L
A
F
Q
F
S
E
A
Q
L
F
E
N
-
T
V
L
K
D
V
E
Y
G
P
-
R
N
F
----
G
-
F
S
-------------
E
-
D
E
A
R
E
A
A
L
K
W
------
L
K
K
V
G
L
-
K
-
D
---
D
L
I
E
H
S
P
F
D
L
S
G
G
Q
M
R
R
V
A
L
A
G
V
L
A
Y
E
P
E
I
I
C
L
D
E
P
A
A
G
L
D
P
M
G
R
L
E
M
M
Q
-
L
F
K
D
Y
Q
-
A
-
A
-
G
H
T
V
I
L
V
T
H
N
M
D
D
V
A
D
Y
A
D
D
V
L
A
L
------
E
H
G
R
----
L
I
K
H
A
S
P
K
E
V
F
K
D
S
E
W
L
Q
K
H
H
L
A
E
P
R
S
A
R
F
A
A
K
L
E
A
A
G
L
K
L
P
G
Q
P
L
T
M
P
E
L
ADAI
K
Q
S
L
K
-
2
PsiBlast_PDB
82.63
56%
-
- C1 -
-
4HZU
-
ECFA2_LACBA
B:
[2-278]
-
A
I
A
F
E
H
V
T
Y
T
Y
Q
A
G
T
P
M
A
H
T
A
L
T
D
V
S
L
T
V
P
D
R
G
Y
L
A
I
I
G
H
T
G
S
G
K
S
T
L
I
Q
Q
L
N
A
L
L
K
P
T
S
G
T
----------
I
K
I
D
E
F
T
I
T
P
E
T
T
N
A
A
L
K
P
L
R
Q
-
H
V
G
M
V
F
Q
F
P
E
N
Q
L
F
E
E
-
T
V
R
Q
D
I
A
F
G
P
-
K
N
F
----
G
-
M
A
-------------
D
-
A
D
A
L
A
L
A
D
E
M
------
L
T
T
V
G
L
-
D
-
Q
---
S
Y
A
E
R
S
P
F
E
L
S
G
G
Q
M
R
R
V
A
I
A
G
V
L
A
M
Q
P
K
V
L
V
L
D
E
P
T
A
G
L
D
P
Q
G
R
Q
E
M
M
R
-
L
F
A
R
L
H
-
Q
E
Q
-
G
L
T
I
V
L
V
T
H
Q
M
E
D
V
A
Q
Y
A
E
Q
V
A
V
M
------
H
E
G
R
----
L
M
K
F
G
T
P
A
D
V
F
S
N
R
E
W
L
Q
D
H
Q
L
D
V
P
Q
A
A
Q
F
A
R
R
L
R
D
R
G
L
T
F
P
K
Q
P
L
T
A
D
Q
L
----
A
D
Y
L
--
1
PsiBlast_PDB
82.57
56%
-
- C1 -
-
4HUQ
-
ECFA2_LACBA
A:
[2-278]
-
A
I
A
F
E
H
V
T
Y
T
Y
Q
A
G
T
P
M
A
H
T
A
L
T
D
V
S
L
T
V
P
D
R
G
Y
L
A
I
I
G
H
T
G
S
G
K
S
T
L
I
Q
Q
L
N
A
L
L
K
P
T
S
G
T
----------
I
K
I
D
E
F
T
I
T
P
E
T
T
N
A
A
L
K
P
L
R
Q
-
H
V
G
M
V
F
Q
F
P
E
N
Q
L
F
E
E
-
T
V
R
Q
D
I
A
F
G
P
-
K
N
F
----
G
-
M
A
-------------
D
-
A
D
A
L
A
L
A
D
E
M
------
L
T
T
V
G
L
-
D
-
Q
---
S
Y
A
E
R
S
P
F
E
L
S
G
G
Q
M
R
R
V
A
I
A
G
V
L
A
M
Q
P
K
V
L
V
L
D
E
P
T
A
G
L
D
P
Q
G
R
Q
E
M
M
R
-
L
F
A
R
L
H
-
Q
E
Q
-
G
L
T
I
V
L
V
T
H
Q
M
E
D
V
A
Q
Y
A
E
Q
V
A
V
M
------
H
E
G
R
----
L
M
K
F
G
T
P
A
D
V
F
S
N
R
E
W
L
Q
D
H
Q
L
D
V
P
Q
A
A
Q
F
A
R
R
L
R
D
R
G
L
T
F
P
K
Q
P
L
T
A
D
Q
L
----
A
D
Y
L
--
3
PsiBlast_PDB
82.55
56%
-
- C1 -
-
4RFS
-
ECFA2_LACBA
A:
[2-278]
-
A
I
A
F
E
H
V
T
Y
T
Y
Q
A
G
T
P
M
A
H
T
A
L
T
D
V
S
L
T
V
P
D
R
G
Y
L
A
I
I
G
H
T
G
S
G
K
S
T
L
I
Q
Q
L
N
A
L
L
K
P
T
S
G
T
----------
I
K
I
D
E
F
T
I
T
P
E
T
T
N
A
A
L
K
P
L
R
Q
-
H
V
G
M
V
F
Q
F
P
E
N
Q
L
F
E
E
-
T
V
R
Q
D
I
A
F
G
P
-
K
N
F
----
G
-
M
A
-------------
D
-
A
D
A
L
A
L
A
D
E
M
------
L
T
T
V
G
L
-
D
-
Q
---
S
Y
A
E
R
S
P
F
E
L
S
G
G
Q
M
R
R
V
A
I
A
G
V
L
A
M
Q
P
K
V
L
V
L
D
E
P
T
A
G
L
D
P
Q
G
R
Q
E
M
M
R
-
L
F
A
R
L
H
-
Q
E
Q
-
G
L
T
I
V
L
V
T
H
Q
M
E
D
V
A
Q
Y
A
E
Q
V
A
V
M
------
H
E
G
R
----
L
M
K
F
G
T
P
A
D
V
F
S
N
R
E
W
L
Q
D
H
Q
L
D
V
P
Q
A
A
Q
F
A
R
R
L
R
D
R
G
L
T
F
P
K
Q
P
L
T
A
D
Q
L
----
A
D
Y
L
--
5
PsiBlast_PDB
82.50
46%
-119
- C1 -
-
5D3M
1
ECFA2_LACDA
B:
[2-282]
-
A
I
K
F
E
N
V
S
Y
V
Y
S
P
G
S
P
L
E
A
I
G
L
D
Q
L
N
F
S
L
E
E
G
K
F
I
A
L
V
G
H
T
G
S
G
K
S
T
L
M
Q
H
F
N
A
L
L
K
P
T
S
G
K
----------
I
E
I
A
G
Y
T
I
T
P
E
T
G
N
K
G
L
K
D
L
R
R
-
K
V
S
L
A
F
Q
F
S
E
A
Q
L
F
E
N
-
T
V
L
K
D
V
E
Y
G
P
-
R
N
F
----
G
-
F
S
-------------
E
-
D
E
A
R
E
A
A
L
K
W
------
L
K
K
V
G
L
-
K
-
D
---
D
L
I
E
H
S
P
F
D
L
S
G
G
Q
M
R
R
V
A
L
A
G
V
L
A
Y
E
P
E
I
I
C
L
D
E
P
A
A
G
L
D
P
M
G
R
L
E
M
M
Q
-
L
F
K
D
Y
Q
-
A
-
A
-
G
H
T
V
I
L
V
T
H
N
M
D
D
V
A
D
Y
A
D
D
V
L
A
L
------
E
H
G
R
----
L
I
K
H
A
S
P
K
E
V
F
K
D
S
E
W
L
Q
K
H
H
L
A
E
P
R
S
A
R
F
A
A
K
L
E
A
A
G
L
K
L
P
G
Q
P
L
T
M
P
E
L
A
D
A
I
K
Q
S
L
K
-
133
HHSearch
82.27
56%
-
- C1 -
-
4HZU
-
ECFA2_LACBA
B:
[2-277]
-
A
I
A
F
E
H
V
T
Y
T
Y
Q
A
G
T
P
M
A
H
T
A
L
T
D
V
S
L
T
V
P
D
R
G
Y
L
A
I
I
G
H
T
G
S
G
K
S
T
L
I
Q
Q
L
N
A
L
L
K
P
T
S
G
T
----------
I
K
I
D
E
F
T
I
T
P
E
T
T
N
A
A
L
K
P
L
R
Q
-
H
V
G
M
V
F
Q
F
P
E
N
Q
L
F
E
E
-
T
V
R
Q
D
I
A
F
G
P
-
K
N
F
----
G
-
M
A
-------------
D
-
A
D
A
L
A
L
A
D
E
M
------
L
T
T
V
G
L
-
D
-
Q
---
S
Y
A
E
R
S
P
F
E
L
S
G
G
Q
M
R
R
V
A
I
A
G
V
L
A
M
Q
P
K
V
L
V
L
D
E
P
T
A
G
L
D
P
Q
G
R
Q
E
M
M
R
-
L
F
A
R
L
H
-
Q
-
E
Q
G
L
T
I
V
L
V
T
H
Q
M
E
D
V
A
Q
Y
A
E
Q
V
A
V
M
------
H
E
G
R
----
L
M
K
F
G
T
P
A
D
V
F
S
N
R
E
W
L
Q
D
H
Q
L
D
V
P
Q
A
A
Q
F
A
R
R
L
R
D
R
G
L
T
F
P
K
Q
P
L
T
A
D
Q
L
----
A
D
Y
---
132
HHSearch
82.22
56%
-
- C1 -
-
4HUQ
-
ECFA2_LACBA
A:
[2-277]
-
A
I
A
F
E
H
V
T
Y
T
Y
Q
A
G
T
P
M
A
H
T
A
L
T
D
V
S
L
T
V
P
D
R
G
Y
L
A
I
I
G
H
T
G
S
G
K
S
T
L
I
Q
Q
L
N
A
L
L
K
P
T
S
G
T
----------
I
K
I
D
E
F
T
I
T
P
E
T
T
N
A
A
L
K
P
L
R
Q
-
H
V
G
M
V
F
Q
F
P
E
N
Q
L
F
E
E
-
T
V
R
Q
D
I
A
F
G
P
-
K
N
F
----
G
-
M
A
-------------
D
-
A
D
A
L
A
L
A
D
E
M
------
L
T
T
V
G
L
-
D
-
Q
---
S
Y
A
E
R
S
P
F
E
L
S
G
G
Q
M
R
R
V
A
I
A
G
V
L
A
M
Q
P
K
V
L
V
L
D
E
P
T
A
G
L
D
P
Q
G
R
Q
E
M
M
R
-
L
F
A
R
L
H
-
Q
-
E
Q
G
L
T
I
V
L
V
T
H
Q
M
E
D
V
A
Q
Y
A
E
Q
V
A
V
M
------
H
E
G
R
----
L
M
K
F
G
T
P
A
D
V
F
S
N
R
E
W
L
Q
D
H
Q
L
D
V
P
Q
A
A
Q
F
A
R
R
L
R
D
R
G
L
T
F
P
K
Q
P
L
T
A
D
Q
L
----
A
D
Y
---
6
PsiBlast_PDB
80.96
46%
-112
- C1 -
-
5JSZ
-
ECFA2_LACDA
B:
[1-282]
M
A
I
K
F
E
N
V
S
Y
V
Y
S
P
G
S
P
L
E
A
I
G
L
D
Q
L
N
F
S
L
E
E
G
K
F
I
A
L
V
G
H
T
G
S
G
K
S
T
L
M
Q
H
F
N
A
L
L
K
P
T
S
G
K
----------
I
E
I
A
G
Y
T
I
T
P
E
T
G
N
K
G
L
K
D
L
R
R
-
K
V
S
L
A
F
Q
F
S
E
A
Q
L
F
E
N
-
T
V
L
K
D
V
E
Y
G
P
-
R
N
F
----
G
-
F
S
-------------
E
-
D
E
A
R
E
A
A
L
K
W
------
L
K
K
V
G
L
-
K
-
D
---
D
L
I
E
H
S
P
F
D
L
S
G
G
Q
M
R
R
V
A
L
A
G
V
L
A
Y
E
P
E
I
I
C
L
D
E
P
A
A
G
L
D
P
M
G
R
L
E
M
M
Q
-
L
F
K
D
Y
Q
-
A
-
A
-
G
H
T
V
I
L
V
T
H
N
M
D
D
V
A
D
Y
A
D
D
V
L
A
L
------
E
H
G
R
----
L
I
K
H
A
S
P
K
E
V
F
K
D
S
E
W
L
Q
K
H
H
L
A
E
P
R
S
A
R
F
A
A
K
L
E
A
A
G
L
K
L
P
G
Q
P
L
T
M
P
E
L
A
D
A
I
K
Q
S
L
K
-
4
PsiBlast_PDB
79.58
50%
-69
- C1 -
-
4MKI
2
ECFA2_CALS4
B:
[5-280]
M
P
I
K
V
E
N
V
S
F
I
Y
N
E
G
T
P
Y
A
T
V
A
L
K
D
I
N
F
S
I
D
D
E
E
F
V
G
I
I
G
H
T
G
S
G
K
S
T
L
I
Q
Q
L
N
G
L
L
K
P
S
K
G
------------
K
I
Y
I
N
G
I
D
I
T
D
K
K
V
S
L
K
D
I
R
K
-
Q
V
G
L
V
F
Q
Y
P
E
Y
Q
L
F
E
E
-
T
V
F
K
D
I
A
F
G
P
-
S
N
L
----
G
-
L
S
-------------
E
-
E
E
V
K
E
R
V
Y
E
A
------
M
E
I
V
G
I
-
S
-
K
---
E
L
A
D
K
S
P
F
E
L
S
G
G
Q
K
R
R
V
A
I
A
G
I
L
A
M
R
P
K
I
L
I
L
D
E
P
T
A
G
L
D
P
K
G
K
Q
E
I
L
N
-
K
I
K
E
I
H
D
K
-
Y
-
K
M
I
T
I
L
V
S
H
N
M
E
D
I
A
R
I
A
D
K
I
I
V
M
------
N
R
G
K
----
I
E
L
I
G
T
P
R
E
V
F
R
E
A
E
R
L
E
K
I
G
L
S
V
P
Q
I
T
S
L
A
R
E
L
R
K
R
G
V
P
I
P
P
D
V
L
T
I
E
E
A
----
K
E
H
I
--
21
PsiBlast_CBE
78.52
50%
-73
- C1 -
-
4MKI
2
ECFA2_CALS4
A:
[5-280]
M
P
I
K
V
E
N
V
S
F
I
Y
N
E
G
T
P
Y
A
T
V
A
L
K
D
I
N
F
S
I
D
D
E
E
F
V
G
I
I
G
H
T
G
S
G
K
S
T
L
I
Q
Q
L
N
G
L
L
K
P
S
K
G
------------
K
I
Y
I
N
G
I
D
I
T
D
K
K
V
S
L
K
D
I
R
K
-
Q
V
G
L
V
F
Q
Y
P
E
Y
Q
L
F
E
E
-
T
V
F
K
D
I
A
F
G
P
-
S
N
L
----
G
-
L
S
-------------
E
-
E
E
V
K
E
R
V
Y
E
A
------
M
E
I
V
G
I
-
S
-
K
---
E
L
A
D
K
S
P
F
E
L
S
G
G
Q
K
R
R
V
A
I
A
G
I
L
A
M
R
P
K
I
L
I
L
D
E
P
T
A
G
L
D
P
K
G
K
Q
E
I
L
N
-
K
I
K
E
I
H
D
K
-
Y
-
K
M
I
T
I
L
V
S
H
N
M
E
D
I
A
R
I
A
D
K
I
I
V
M
------
N
R
G
K
----
I
E
L
I
G
T
P
R
E
V
F
R
E
A
E
R
L
E
K
I
G
L
S
V
P
Q
I
T
S
L
A
R
E
L
R
K
R
G
V
P
I
P
P
D
V
L
T
I
E
E
A
----
K
E
H
I
--
143
HHSearch
77.70
51%
-92
- C1 -
-
4MKI
2
ECFA2_CALS4
A:
[6-267]
-
P
I
K
V
E
N
V
S
F
I
Y
N
E
G
T
P
Y
A
T
V
A
L
K
D
I
N
F
S
I
D
D
E
E
F
V
G
I
I
G
H
T
G
S
G
K
S
T
L
I
Q
Q
L
N
G
L
L
K
P
S
K
G
K
----------
I
Y
I
N
G
I
D
I
T
D
K
K
--
V
S
L
K
D
I
R
K
-
Q
V
G
L
V
F
Q
Y
P
E
Y
Q
L
F
E
E
-
T
V
F
K
D
I
A
F
G
P
-
S
N
L
----
G
-
L
S
-------------
E
-
E
E
V
K
E
R
V
Y
E
A
------
M
E
I
V
G
I
-
S
-
K
---
E
L
A
D
K
S
P
F
E
L
S
G
G
Q
K
R
R
V
A
I
A
G
I
L
A
M
R
P
K
I
L
I
L
D
E
P
T
A
G
L
D
P
K
G
K
Q
E
I
L
N
-
K
I
K
E
I
H
-
D
-
K
Y
K
M
I
T
I
L
V
S
H
N
M
E
D
I
A
R
I
A
D
K
I
I
V
M
------
N
R
G
K
----
I
E
L
I
G
T
P
R
E
V
F
R
E
A
E
R
L
E
K
I
G
L
S
V
P
Q
I
T
S
L
A
R
E
L
R
K
R
G
V
P
I
P
-------------------
25
PsiBlast_CBE
76.54
39%
-131
- C1 -
-
5X40
2
CBIO_RHOCB
B:
[17-275]
--
L
A
A
E
A
L
T
Y
A
F
P
G
G
V
----
K
A
L
D
D
L
S
L
A
V
P
K
G
E
S
L
A
I
L
G
P
N
G
A
G
K
S
T
L
L
L
H
L
N
G
T
L
R
P
Q
S
G
R
----------
V
L
L
G
G
T
--
A
T
G
H
S
R
K
D
L
T
G
W
R
R
-
R
V
G
L
V
L
Q
D
A
D
D
Q
L
F
A
T
-
T
V
F
E
D
V
S
F
G
P
-
L
N
L
----
G
-
L
S
-------------
E
-
A
E
A
R
A
R
V
E
E
A
------
L
A
A
L
S
I
-
S
-
D
----
L
R
D
R
P
T
H
M
L
S
G
G
Q
K
R
R
V
A
I
A
G
A
V
A
M
R
P
E
V
L
L
L
D
Q
P
T
A
G
L
D
L
A
G
T
E
Q
L
L
T
-
L
L
R
G
L
R
-
A
-
A
-
G
M
T
L
V
F
S
T
H
D
V
E
L
A
A
A
L
A
D
R
V
A
L
F
------
R
T
G
R
----
V
L
A
E
G
A
A
E
A
V
L
S
D
R
A
T
L
A
K
V
A
L
R
P
P
L
V
I
D
L
A
L
L
A
R
D
H
G
L
L
A
P
E
A
P
L
---------------
10
PsiBlast_PDB
75.90
39%
-132
- C1 -
-
5X40
2
CBIO_RHOCB
A:
[17-275]
--
L
A
A
E
A
L
T
Y
A
F
P
G
G
V
----
K
A
L
D
D
L
S
L
A
V
P
K
G
E
S
L
A
I
L
G
P
N
G
A
G
K
S
T
L
L
L
H
L
N
G
T
L
R
P
Q
S
G
R
----------
V
L
L
G
G
T
--
A
T
G
H
S
R
K
D
L
T
G
W
R
R
-
R
V
G
L
V
L
Q
D
A
D
D
Q
L
F
A
T
-
T
V
F
E
D
V
S
F
G
P
-
L
N
L
----
G
-
L
S
-------------
E
-
A
E
A
R
A
R
V
E
E
A
------
L
A
A
L
S
I
-
S
-
D
----
L
R
D
R
P
T
H
M
L
S
G
G
Q
K
R
R
V
A
I
A
G
A
V
A
M
R
P
E
V
L
L
L
D
Q
P
T
A
G
L
D
L
A
G
T
E
Q
L
L
T
-
L
L
R
G
L
R
-
A
-
A
-
G
M
T
L
V
F
S
T
H
D
V
E
L
A
A
A
L
A
D
R
V
A
L
F
------
R
T
G
R
----
V
L
A
E
G
A
A
E
A
V
L
S
D
R
A
T
L
A
K
V
A
L
R
P
P
L
V
I
D
L
A
L
L
A
R
D
H
G
L
L
A
P
E
A
P
L
---------------
145
HHSearch
75.29
41%
-132
- C1 -
-
5X40
2
CBIO_RHOCB
A:
[17-267]
--
L
A
A
E
A
L
T
Y
A
F
P
G
G
----
V
K
A
L
D
D
L
S
L
A
V
P
K
G
E
S
L
A
I
L
G
P
N
G
A
G
K
S
T
L
L
L
H
L
N
G
T
L
R
P
Q
S
G
R
----------
V
L
L
G
G
T
A
T
G
H
S
R
--
K
D
L
T
G
W
R
R
-
R
V
G
L
V
L
Q
D
A
D
D
Q
L
F
A
T
-
T
V
F
E
D
V
S
F
G
P
-
L
N
L
----
G
-
L
S
-------------
E
-
A
E
A
R
A
R
V
E
E
A
------
L
A
A
L
S
I
-
S
-----
D
L
R
D
R
P
T
H
M
L
S
G
G
Q
K
R
R
V
A
I
A
G
A
V
A
M
R
P
E
V
L
L
L
D
Q
P
T
A
G
L
D
L
A
G
T
E
Q
L
L
T
-
L
L
R
G
L
R
-
A
-
A
-
G
M
T
L
V
F
S
T
H
D
V
E
L
A
A
A
L
A
D
R
V
A
L
F
------
R
T
G
R
----
V
L
A
E
G
A
A
E
A
V
L
S
D
R
A
T
L
A
K
V
A
L
R
P
P
L
V
I
D
L
A
L
L
A
R
D
H
G
-----------------------
8
PsiBlast_PDB
71.44
39%
-131
- C1 -
-
5X3X
-
CBIO_RHOCB
A:
[5-263]
--
L
A
A
E
A
L
T
Y
A
F
P
G
G
V
----
K
A
L
D
D
L
S
L
A
V
P
K
G
E
S
L
A
I
L
G
P
N
G
A
G
K
S
T
L
L
L
H
L
N
G
T
L
R
P
Q
S
G
R
----------
V
L
L
G
G
T
--
A
T
G
H
S
R
K
D
L
T
G
W
R
R
-
R
V
G
L
V
L
Q
D
A
D
D
Q
L
F
A
T
-
T
V
F
E
D
V
S
F
G
P
-
L
N
L
----
G
-
L
S
-------------
E
-
A
E
A
R
A
R
V
E
E
A
------
L
A
A
L
S
I
-
S
-
D
----
L
R
D
R
P
T
H
M
L
S
G
G
Q
K
R
R
V
A
I
A
G
A
V
A
M
R
P
E
V
L
L
L
D
E
P
T
A
G
L
D
L
A
G
T
E
Q
L
L
T
-
L
L
R
G
L
R
-
A
-
A
-
G
M
T
L
V
F
S
T
H
D
V
E
L
A
A
A
L
A
D
R
V
A
L
F
------
R
T
G
R
----
V
L
A
E
G
A
A
E
A
V
L
S
D
R
A
T
L
A
K
V
A
L
R
P
P
L
V
I
D
L
A
L
L
A
R
D
H
G
L
L
A
P
E
A
P
L
---------------
142
HHSearch
70.96
43%
-129
- C1 -
-
5X3X
-
CBIO_RHOCB
B:
[4-231]
-
I
L
A
A
E
A
L
T
Y
A
F
P
G
G
----
V
K
A
L
D
D
L
S
L
A
V
P
K
G
E
S
L
A
I
L
G
P
N
G
A
G
K
S
T
L
L
L
H
L
N
G
T
L
R
P
Q
S
G
R
----------
V
L
L
G
G
T
A
T
G
H
S
R
--
K
D
L
T
G
W
R
R
-
R
V
G
L
V
L
Q
D
A
D
D
Q
L
F
A
T
-
T
V
F
E
D
V
S
F
G
P
-
L
N
L
----
G
-
L
S
-------------
E
-
A
E
A
R
A
R
V
E
E
A
------
L
A
A
L
S
I
-
S
-----
D
L
R
D
R
P
T
H
M
L
S
G
G
Q
K
R
R
V
A
I
A
G
A
V
A
M
R
P
E
V
L
L
L
D
E
P
T
A
G
L
D
L
A
G
T
E
Q
L
L
T
-
L
L
R
G
L
R
-
A
-
A
-
G
M
T
L
V
F
S
T
H
D
V
E
L
A
A
A
L
A
D
R
V
A
L
F
------
R
T
G
R
----
V
L
A
E
G
A
A
E
A
V
L
S
D
R
-----------------------------------------------
7
PsiBlast_PDB
69.02
39%
-110
- C1 -
-
3GFO
-
ECFA3_CLOP1
A:
[8-254]
--
L
K
V
E
E
L
N
Y
N
Y
S
D
G
T
----
H
A
L
K
G
I
N
M
N
I
K
R
G
E
V
T
A
I
L
G
G
N
G
V
G
K
S
T
L
F
Q
N
F
N
G
I
L
K
P
S
S
G
R
----------
I
-
L
F
D
N
K
P
I
D
Y
S
R
-
K
G
I
M
K
L
R
E
-
S
I
G
I
V
F
Q
D
P
D
N
Q
L
F
S
A
-
S
V
Y
Q
D
V
S
F
G
A
-
V
N
M
----
K
-
L
P
-------------
E
-
D
E
I
R
K
R
V
D
N
A
------
L
K
R
T
G
I
---
E
---
H
L
K
D
K
P
T
H
C
L
S
F
G
Q
K
K
R
V
A
I
A
G
V
L
V
M
E
P
K
V
L
I
L
D
E
P
T
A
G
L
D
P
M
G
V
S
E
I
M
K
-
L
L
V
E
M
Q
-
K
-
E
L
G
I
T
I
I
I
A
T
H
D
I
D
I
V
P
L
Y
C
D
N
V
F
V
M
------
K
E
G
R
----
V
I
L
Q
G
N
P
K
E
V
F
A
E
K
E
V
I
R
K
V
N
L
R
L
P
R
I
G
H
L
M
E
I
----------------------------
9
PsiBlast_PDB
66.79
39%
-130
- C1 -
-
5X41
-
?
A:
[5-263]
--
L
A
A
E
A
L
T
Y
A
F
P
G
G
V
----
K
A
L
D
D
L
S
L
A
V
P
K
G
E
S
L
A
I
L
G
P
N
G
A
G
K
S
T
L
L
L
H
L
N
G
T
L
R
P
Q
S
G
R
----------
V
L
L
G
G
T
--
A
------
D
L
T
G
W
R
R
-
R
V
G
L
V
L
Q
D
A
D
D
Q
L
F
A
T
-
T
V
F
E
D
V
S
F
G
P
-
L
N
L
----
G
-
L
S
-------------
E
-
A
E
A
R
A
R
V
E
E
A
------
L
A
A
L
S
I
-
S
-
D
----
L
R
D
R
P
T
H
M
L
S
G
G
Q
K
R
R
V
A
I
A
G
A
V
A
M
R
P
E
V
L
L
L
D
E
P
T
A
G
L
D
L
A
G
T
E
Q
L
L
T
-
L
L
R
G
L
R
-
A
-
A
-
G
M
T
L
V
F
S
T
H
D
V
E
L
A
A
A
L
A
D
R
V
A
L
F
------
R
T
G
R
----
V
L
A
E
G
A
A
E
A
V
L
S
D
R
A
T
L
A
K
V
A
L
R
P
P
L
V
I
D
L
A
L
L
A
R
D
H
G
L
L
A
P
E
A
P
L
---------------
13
PsiBlast_PDB
64.67
41%
-89
- C1 -
-
4HLU
1
ECFA2_THEMA
A:
[5-222]
--
I
E
V
V
N
V
S
H
I
F
H
R
G
T
P
L
E
K
K
A
L
E
N
V
S
L
V
I
N
E
G
E
C
L
L
V
A
G
N
T
G
S
G
K
S
T
L
L
Q
I
V
A
G
L
I
E
P
T
S
G
D
----------
V
-
L
Y
D
------
G
E
R
K
K
G
Y
E
I
R
R
-
N
I
G
I
A
F
Q
Y
P
E
D
Q
F
F
A
E
-
R
V
F
D
E
V
A
F
A
V
-
K
N
F
------
Y
P
-------------
D
-
R
D
P
V
P
L
V
K
K
A
------
M
E
F
V
G
L
-
D
F
D
---
S
F
K
D
R
V
P
F
F
L
S
G
G
E
K
R
R
V
A
I
A
S
V
I
V
H
E
P
D
I
L
I
L
D
E
P
L
V
G
L
D
R
E
G
K
T
D
L
L
R
-
I
V
E
K
W
K
-
T
-
L
-
G
K
T
V
I
L
I
S
H
D
I
E
T
V
I
N
H
V
D
R
V
V
V
L
------
E
K
G
K
----
K
V
F
D
G
--------------------------------------------------------
26
PsiBlast_CBE
64.39
41%
-89
- C1 -
-
4HLU
1
ECFA2_THEMA
B:
[5-222]
--
I
E
V
V
N
V
S
H
I
F
H
R
G
T
P
L
E
K
K
A
L
E
N
V
S
L
V
I
N
E
G
E
C
L
L
V
A
G
N
T
G
S
G
K
S
T
L
L
Q
I
V
A
G
L
I
E
P
T
S
G
D
----------
V
-
L
Y
D
------
G
E
R
K
K
G
Y
E
I
R
R
-
N
I
G
I
A
F
Q
Y
P
E
D
Q
F
F
A
E
-
R
V
F
D
E
V
A
F
A
V
-
K
N
F
------
Y
P
-------------
D
-
R
D
P
V
P
L
V
K
K
A
------
M
E
F
V
G
L
-
D
F
D
---
S
F
K
D
R
V
P
F
F
L
S
G
G
E
K
R
R
V
A
I
A
S
V
I
V
H
E
P
D
I
L
I
L
D
E
P
L
V
G
L
D
R
E
G
K
T
D
L
L
R
-
I
V
E
K
W
K
-
T
-
L
-
G
K
T
V
I
L
I
S
H
D
I
E
T
V
I
N
H
V
D
R
V
V
V
L
------
E
K
G
K
----
K
V
F
D
G
--------------------------------------------------------
52
PsiBlast_CBE
56.31
38%
-66
- C1 -
-
2OLK
1
?
C:
[40-247]
----------------------
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
----------
I
-
I
I
D
G
-
I
N
L
K
A
K
D
T
N
L
N
K
V
R
E
-
E
V
G
M
V
F
Q
R
F
-
N
L
F
P
H
M
-
T
V
L
N
N
I
T
L
A
P
-
M
K
V
R---
K
-
W
P
-------------
R
-
E
K
A
E
A
K
A
M
E
L
------
L
D
K
V
G
L
-
K
-
D
---
K
A
H
-
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
-
V
M
K
Q
L
A
-
N
-
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
------
D
G
G
Y
----
I
I
E
E
G
K
P
E
D
L
F
--------------------------------------------------
46
PsiBlast_CBE
54.58
38%
-69
- C1 -
-
2Q0H
3
?
A:
[40-247]
----------------------
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
----------
I
-
I
I
D
G
-
I
N
L
K
A
K
D
T
N
L
N
K
V
R
E
-
E
V
G
M
V
F
Q
R
F
-
N
L
F
P
H
M
-
T
V
L
N
N
I
T
L
A
P
-
M
K
V
R---
K
-
W
P
-------------
R
-
E
K
A
E
A
K
A
M
E
L
------
L
D
K
V
G
L
-
K
-
D
---
K
A
H
-
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
-
V
M
K
Q
L
A
-
N
-
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
------
D
G
G
Y
----
I
I
E
E
G
K
P
E
D
L
F
--------------------------------------------------
57
PsiBlast_CBE
54.37
38%
-71
- C1 -
-
3C41
2
?
K:
[19-226]
----------------------
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
----------
I
-
I
I
D
G
-
I
N
L
K
A
K
D
T
N
L
N
K
V
R
E
-
E
V
G
M
V
F
Q
R
F
-
N
L
F
P
H
M
-
T
V
L
N
N
I
T
L
A
P
-
M
K
V
R---
K
-
W
P
-------------
R
-
E
K
A
E
A
K
A
M
E
L
------
L
D
K
V
G
L
-
K
-
D
---
K
A
H
-
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
-
V
M
K
Q
L
A
-
N
-
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
------
D
G
G
Y
----
I
I
E
E
G
K
P
E
D
L
F
--------------------------------------------------
54
PsiBlast_CBE
53.52
38%
-69
- C1 -
-
2OLK
1
?
A:
[40-247]
----------------------
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
----------
I
-
I
I
D
G
-
I
N
L
K
A
K
D
T
N
L
N
K
V
R
E
-
E
V
G
M
V
F
Q
R
F
-
N
L
F
P
H
M
-
T
V
L
N
N
I
T
L
A
P
-
M
K
V
R---
K
-
W
P
-------------
R
-
E
K
A
E
A
K
A
M
E
L
------
L
D
K
V
G
L
-
K
-
D
---
K
A
H
-
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
-
V
M
K
Q
L
A
-
N
-
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
------
D
G
G
Y
----
I
I
E
E
G
K
P
E
D
L
F
--------------------------------------------------
53
PsiBlast_CBE
52.83
38%
-75
- C1 -
-
2OLK
2
?
B:
[40-247]
----------------------
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
----------
I
-
I
I
D
G
-
I
N
L
K
A
K
D
T
N
L
N
K
V
R
E
-
E
V
G
M
V
F
Q
R
F
-
N
L
F
P
H
M
-
T
V
L
N
N
I
T
L
A
P
-
M
K
V
R---
K
-
W
P
-------------
R
-
E
K
A
E
A
K
A
M
E
L
------
L
D
K
V
G
L
-
K
-
D
---
K
A
H
-
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
-
V
M
K
Q
L
A
-
N
-
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
------
D
G
G
Y
----
I
I
E
E
G
K
P
E
D
L
F
--------------------------------------------------
44
PsiBlast_CBE
52.47
38%
-67
- C1 -
-
3C4J
2
?
A:
[40-247]
----------------------
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
----------
I
-
I
I
D
G
-
I
N
L
K
A
K
D
T
N
L
N
K
V
R
E
-
E
V
G
M
V
F
Q
R
F
-
N
L
F
P
H
M
-
T
V
L
N
N
I
T
L
A
P
-
M
K
V
R---
K
-
W
P
-------------
R
-
E
K
A
E
A
K
A
M
E
L
------
L
D
K
V
G
L
-
K
-
D
---
K
A
H
-
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
-
V
M
K
Q
L
A
-
N
-
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
------
D
G
G
Y
----
I
I
E
E
G
K
P
E
D
L
F
--------------------------------------------------
43
PsiBlast_CBE
52.30
38%
-63
- C1 -
-
3C4J
2
?
B:
[40-247]
----------------------
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
----------
I
-
I
I
D
G
-
I
N
L
K
A
K
D
T
N
L
N
K
V
R
E
-
E
V
G
M
V
F
Q
R
F
-
N
L
F
P
H
M
-
T
V
L
N
N
I
T
L
A
P
-
M
K
V
R---
K
-
W
P
-------------
R
-
E
K
A
E
A
K
A
M
E
L
------
L
D
K
V
G
L
-
K
-
D
---
K
A
H
-
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
-
V
M
K
Q
L
A
-
N
-
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
------
D
G
G
Y
----
I
I
E
E
G
K
P
E
D
L
F
--------------------------------------------------
55
PsiBlast_CBE
51.96
38%
-64
- C1 -
-
2OLJ
2
?
B:
[40-247]
----------------------
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
----------
I
-
I
I
D
G
-
I
N
L
K
A
K
D
T
N
L
N
K
V
R
E
-
E
V
G
M
V
F
Q
R
F
-
N
L
F
P
H
M
-
T
V
L
N
N
I
T
L
A
P
-
M
K
V
R---
K
-
W
P
-------------
R
-
E
K
A
E
A
K
A
M
E
L
------
L
D
K
V
G
L
-
K
-
D
---
K
A
H
-
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
-
V
M
K
Q
L
A
-
N
-
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
------
D
G
G
Y
----
I
I
E
E
G
K
P
E
D
L
F
--------------------------------------------------
45
PsiBlast_CBE
51.91
38%
-72
- C1 -
-
2Q0H
3
?
B:
[40-247]
----------------------
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
----------
I
-
I
I
D
G
-
I
N
L
K
A
K
D
T
N
L
N
K
V
R
E
-
E
V
G
M
V
F
Q
R
F
-
N
L
F
P
H
M
-
T
V
L
N
N
I
T
L
A
P
-
M
K
V
R---
K
-
W
P
-------------
R
-
E
K
A
E
A
K
A
M
E
L
------
L
D
K
V
G
L
-
K
-
D
---
K
A
H
-
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
-
V
M
K
Q
L
A
-
N
-
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
------
D
G
G
Y
----
I
I
E
E
G
K
P
E
D
L
F
--------------------------------------------------
58
PsiBlast_CBE
51.53
38%
-63
- C1 -
-
3C41
2
?
J:
[19-226]
----------------------
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
----------
I
-
I
I
D
G
-
I
N
L
K
A
K
D
T
N
L
N
K
V
R
E
-
E
V
G
M
V
F
Q
R
F
-
N
L
F
P
H
M
-
T
V
L
N
N
I
T
L
A
P
-
M
K
V
R---
K
-
W
P
-------------
R
-
E
K
A
E
A
K
A
M
E
L
------
L
D
K
V
G
L
-
K
-
D
---
K
A
H
-
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
-
V
M
K
Q
L
A
-
N
-
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
------
D
G
G
Y
----
I
I
E
E
G
K
P
E
D
L
F
--------------------------------------------------
131
PsiBlast_CBE
51.47
31%
-57
- C1 -
-
3NH6
2
A:
[54-287]
--
I
E
F
E
N
V
H
F
S
Y
A
D
G
----
R
E
T
L
Q
D
V
S
F
T
V
M
P
G
Q
T
L
A
L
V
G
P
S
G
A
G
K
S
T
I
L
R
L
L
F
R
F
Y
D
I
S
S
G
C
----------
I
R
I
D
G
Q
D
I
S
Q
V
T
Q
A
S
----
L
R
S
-
H
I
G
V
V
P
Q
--
D
T
V
L
F
N
D
-
T
I
A
D
N
I
R
Y
G
R
-
V
T
A
----
G
-
N
D
-------------
E
V
E
A
A
A
Q
A
A
G
I
H
------
D
A
I
M
A
F
-
P
-
E
GYR
T
Q
V
G
E
R
G
L
K
L
S
G
G
E
K
Q
R
V
A
I
A
R
T
I
L
K
A
P
G
I
I
L
L
D
E
A
T
S
A
L
D
T
S
N
E
R
A
I
Q
A
-
S
L
A
K
V
C
-
A
-
N
-
R
T
T
I
V
-
V
A
H
R
L
S
T
V
V
N
-
A
D
Q
I
L
V
I
K
DGCIV
E
R
G
R
H
E
A
L
L
S
R
G
G
V
Y
A
D
M
W
Q
-------------------------------------------------
51
PsiBlast_CBE
51.46
38%
-73
- C1 -
-
2OLK
1
?
D:
[40-247]
----------------------
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
----------
I
-
I
I
D
G
-
I
N
L
K
A
K
D
T
N
L
N
K
V
R
E
-
E
V
G
M
V
F
Q
R
F
-
N
L
F
P
H
M
-
T
V
L
N
N
I
T
L
A
P
-
M
K
V
R---
K
-
W
P
-------------
R
-
E
K
A
E
A
K
A
M
E
L
------
L
D
K
V
G
L
-
K
-
D
---
K
A
H
-
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
-
V
M
K
Q
L
A
-
N
-
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
------
D
G
G
Y
----
I
I
E
E
G
K
P
E
D
L
F
--------------------------------------------------
56
PsiBlast_CBE
51.35
38%
-71
- C1 -
-
2OLJ
3
?
A:
[40-247]
----------------------
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
----------
I
-
I
I
D
G
-
I
N
L
K
A
K
D
T
N
L
N
K
V
R
E
-
E
V
G
M
V
F
Q
R
F
-
N
L
F
P
H
M
-
T
V
L
N
N
I
T
L
A
P
-
M
K
V
R---
K
-
W
P
-------------
R
-
E
K
A
E
A
K
A
M
E
L
------
L
D
K
V
G
L
-
K
-
D
---
K
A
H
-
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
-
V
M
K
Q
L
A
-
N
-
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
------
D
G
G
Y
----
I
I
E
E
G
K
P
E
D
L
F
--------------------------------------------------
73
PsiBlast_CBE
49.68
34%
-47
- C1 -
-
3TIF
4
Y796_METJA
B:
[2-223]
--
V
K
L
K
N
V
T
K
T
Y
K
M
G
E
E
I
I
Y
A
-
L
K
N
V
N
L
N
I
K
E
G
E
F
V
S
I
M
G
P
S
G
S
G
K
S
T
M
L
N
I
I
G
C
L
D
K
P
T
E
G
E
----------
V
Y
I
-
D
N
I
K
T
N
D
L
D
D
D
E
L
T
K
I
R
R
D
K
I
G
F
V
F
Q
-
Q
F
N
L
I
P
L
L
-
T
A
L
E
N
V
E
L
-
P
-
L
I
F
KYRG
A
-
M
S
-------------
G
-
E
E
R
R
K
R
A
L
E
C
------
L
K
M
A
E
L
-
E
-
E
---
R
F
A
N
H
K
P
N
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
N
N
P
P
I
I
L
A
D
Q
P
T
W
A
L
D
S
K
T
G
E
K
I
M
Q
-
L
L
K
K
L
N
E
E
-
D
-
G
K
T
V
V
V
V
T
H
D
I
-
N
V
A
R
F
G
E
R
I
I
Y
L
------
K
D
G
E
----
V
------------------------------------------------------------
130
PsiBlast_CBE
48.44
31%
-56
- C1 -
-
3NH9
3
A:
[54-287]
--
I
E
F
E
N
V
H
F
S
Y
A
D
G
----
R
E
T
L
Q
D
V
S
F
T
V
M
P
G
Q
T
L
A
L
V
G
P
S
G
A
G
K
S
T
I
L
R
L
L
F
R
F
Y
D
I
S
S
G
C
----------
I
R
I
D
G
Q
D
I
S
Q
V
T
Q
A
S
----
L
R
S
-
H
I
G
V
V
P
Q
--
D
T
V
L
F
N
D
-
T
I
A
D
N
I
R
Y
G
R
-
V
T
A
----
G
-
N
D
-------------
E
V
E
A
A
A
Q
A
A
G
I
H
------
D
A
I
M
A
F
-
P
-
E
GYR
T
Q
V
G
E
R
G
L
K
L
S
G
G
E
K
Q
R
V
A
I
A
R
T
I
L
K
A
P
G
I
I
L
L
D
E
A
T
S
A
L
D
T
S
N
E
R
A
I
Q
A
-
S
L
A
K
V
C
-
A
-
N
-
R
T
T
I
V
-
V
A
H
R
L
S
T
V
V
N
-
A
D
Q
I
L
V
I
K
DGCIV
E
R
G
R
H
E
A
L
L
S
R
G
G
V
Y
A
D
M
W
Q
-------------------------------------------------
67
PsiBlast_CBE
48.04
38%
-7
- C1 -
-
1B0U
1
HISP_SALTY
A:
[22-241]
----------------------
L
K
G
V
S
L
Q
A
R
A
G
D
V
I
S
I
I
G
S
S
G
S
G
K
S
T
F
L
R
C
I
N
F
L
E
K
P
S
E
G
A
I
I
V
NGQNI
N
L
V
R
D
K
D
G
Q
L
K
V
A
D
K
N
Q
-
L
R
L
L
R
T
-
R
L
T
M
V
F
Q
H
F
-
N
L
W
S
H
M
-
T
V
L
E
N
V
M
E
A
P
I
Q
V
L
----
G
-
L
S
-------------
K
-
H
D
A
R
E
R
A
L
K
Y
------
L
A
K
V
G
I
-
D
-
E
---
R
A
Q
G
K
Y
P
V
H
L
S
G
G
Q
Q
Q
R
V
S
I
A
R
A
L
A
M
E
P
D
V
L
L
F
D
E
P
T
S
A
L
D
P
E
L
V
G
E
V
L
R
-
I
M
Q
Q
L
A
-
E
-
E
-
G
K
T
M
V
V
V
T
H
E
M
G
F
A
R
H
V
S
S
H
V
I
F
L
------
H
Q
G
K
----
I
E
E
E
G
D
P
E
Q
V
F
--------------------------------------------------
128
PsiBlast_CBE
48.01
31%
-58
- C1 -
-
3NHB
2
A:
[54-287]
--
I
E
F
E
N
V
H
F
S
Y
A
D
-----
R
E
T
L
Q
D
V
S
F
T
V
M
P
G
Q
T
L
A
L
V
G
P
S
G
A
G
K
S
T
I
L
R
L
L
F
R
F
Y
D
I
S
S
G
C
----------
I
R
I
D
G
Q
D
I
S
Q
V
T
Q
A
S
----
L
R
S
-
H
I
G
V
V
P
Q
--
D
T
V
L
F
N
D
-
T
I
A
D
N
I
R
Y
G
R
-
V
T
A
----
G
-
N
D
-------------
E
V
E
A
A
A
Q
A
A
G
I
H
------
D
A
I
M
A
F
-
P
-
E
GYR
T
Q
V
G
E
R
G
L
K
L
S
G
G
E
K
Q
R
V
A
I
A
R
T
I
L
K
A
P
G
I
I
L
L
D
E
A
T
S
A
L
D
T
S
N
E
R
A
I
Q
A
-
S
L
A
K
V
C
-
A
-
N
-
R
T
T
I
V
-
V
A
H
R
L
S
T
V
V
N
-
A
D
Q
I
L
V
I
K
DGCIV
E
R
G
R
H
E
A
L
L
S
R
G
G
V
Y
A
D
M
W
Q
-------------------------------------------------
14
PsiBlast_PDB
47.01
40%
-9
- C1 -
-
4U00
1
?
A:
[20-226]
----------------------
L
K
G
I
H
L
E
V
A
P
G
E
K
L
V
I
I
G
P
S
G
S
G
K
S
T
L
I
R
T
I
N
R
L
E
D
F
Q
E
G
E
----------
V
-
V
V
D
G
L
--
S
V
K
D
D
R
A
L
R
E
I
R
R
-
E
V
G
M
V
F
Q
-
Q
F
N
L
F
P
H
M
-
T
V
L
E
N
V
T
L
A
P
-
M
R
V
----
R
R
W
P
-------------
R
-
E
K
A
E
K
K
A
L
E
L
------
L
E
R
V
G
I
L
D
-
Q
---
A
--
R
K
Y
P
A
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
D
-
V
M
R
D
L
A
-
Q
-
G
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
A
D
R
V
V
F
M
------
D
G
G
Q
----
I
V
E
E
G
R
P
E
E
I
F
--------------------------------------------------
104
PsiBlast_CBE
46.26
31%
-30
- C1 -
-
1G9X
1
LIVG_METJA
B:
[22-245]
---------------------
A
L
D
G
V
S
I
S
V
C
K
G
D
V
T
L
I
I
G
P
N
G
S
G
K
S
T
L
I
N
V
I
T
G
F
L
K
A
D
E
G
R
----------
V
Y
F
E
N
K
D
I
T
----
N
K
E
P
A
E
L
Y
--
H
Y
G
I
V
R
T
F
Q
T
P
Q
P
L
K
E
M
T
V
L
E
N
L
L
I
G
E
-
I
N
P
----
G
-
E
S
PLNSLFYKKWIPK
E
-
E
E
M
V
E
K
A
F
K
I
------
L
E
F
L
K
L
-
S
-
H
----
L
Y
D
R
K
A
G
E
L
S
G
G
Q
M
K
L
V
E
I
G
R
A
L
M
T
N
P
K
M
I
V
M
D
E
P
I
A
G
V
A
P
G
L
A
H
D
I
F
N
-
H
V
L
E
L
K
-
A
-
K
-
G
I
T
F
L
I
I
E
H
R
L
D
I
V
L
N
Y
I
D
H
L
Y
V
M
------
F
N
G
Q
----
I
I
A
E
G
R
G
E
E
E
I
K
N
V
L
----------------------------------------------
105
PsiBlast_CBE
45.50
31%
-25
- C1 -
-
1G9X
2
LIVG_METJA
A:
[22-245]
---------------------
A
L
D
G
V
S
I
S
V
C
K
G
D
V
T
L
I
I
G
P
N
G
S
G
K
S
T
L
I
N
V
I
T
G
F
L
K
A
D
E
G
R
----------
V
Y
F
E
N
K
D
I
T
----
N
K
E
P
A
E
L
Y
--
H
Y
G
I
V
R
T
F
Q
T
P
Q
P
L
K
E
M
T
V
L
E
N
L
L
I
G
E
-
I
N
P
----
G
-
E
S
P
L
N
S
L
F
Y
KKWIPK
E
-
E
E
M
V
E
K
A
F
K
I
------
L
E
F
L
K
L
-
S
-
H
----
L
Y
D
R
K
A
G
E
L
S
G
G
Q
M
K
L
V
E
I
G
R
A
L
M
T
N
P
K
M
I
V
M
D
E
P
I
A
G
V
A
P
G
L
A
H
D
I
F
N
-
H
V
L
E
L
K
-
A
-
K
-
G
I
T
F
L
I
I
E
H
R
L
D
I
V
L
N
Y
I
D
H
L
Y
V
M
------
F
N
G
Q
----
I
I
A
E
G
R
G
E
E
E
I
K
N
V
L
----------------------------------------------
103
PsiBlast_CBE
44.77
31%
-25
- C1 -
-
1G9X
1
LIVG_METJA
C:
[22-245]
---------------------
A
L
D
G
V
S
I
S
V
C
K
G
D
V
T
L
I
I
G
P
N
G
S
G
K
S
T
L
I
N
V
I
T
G
F
L
K
A
D
E
G
R
----------
V
Y
F
E
N
K
D
I
T
----
N
K
E
P
A
E
L
Y
--
H
Y
G
I
V
R
T
F
Q
T
P
Q
P
L
K
E
M
T
V
L
E
N
L
L
I
G
E
-
I
N
P
----
G
-
E
S
PLNSLFYKKWIPK
E
-
E
E
M
V
E
K
A
F
K
I
------
L
E
F
L
K
L
-
S
-
H
----
L
Y
D
R
K
A
G
E
L
S
G
G
Q
M
K
L
V
E
I
G
R
A
L
M
T
N
P
K
M
I
V
M
D
E
P
I
A
G
V
A
P
G
L
A
H
D
I
F
N
-
H
V
L
E
L
K
-
A
-
K
-
G
I
T
F
L
I
I
E
H
R
L
D
I
V
L
N
Y
I
D
H
L
Y
V
M
------
F
N
G
Q
----
I
I
A
E
G
R
G
E
E
E
I
K
N
V
L
----------------------------------------------
111
PsiBlast_CBE
40.07
32%
-21
- C1 -
-
3FVQ
2
FBPC_NEIG1
A:
[20-233]
----------------------
L
N
D
I
S
L
S
L
D
P
G
E
I
L
F
I
I
G
A
S
G
C
G
K
T
T
L
L
R
C
L
A
G
F
E
Q
P
D
S
G
E
----------
I
S
L
S
G
K
T
I
F
S
K
N
T
N
L
P
V
R
E
--
R
-
R
L
G
Y
L
V
Q
--
E
G
V
L
F
P
H
L
T
V
Y
R
N
I
A
Y
G
L
-
G
N
-------------------------
G
K
G
R
T
A
Q
E
R
Q
R
I
E
A
M
L
E
L
T
G
I
-
S
-
E
----
L
A
G
R
Y
P
H
E
L
S
G
G
Q
Q
Q
R
A
A
L
A
R
A
L
A
P
D
P
E
L
I
L
L
D
E
P
F
S
A
L
D
E
Q
L
R
R
Q
I
R
E
D
M
I
A
A
L
R
-
A
-
N
-
G
K
S
A
V
F
V
S
H
D
R
E
E
A
L
Q
Y
A
D
R
I
A
V
M
------
K
Q
G
R
----
I
L
Q
T
A
S
P
H
E
L
Y
R
-------------------------------------------------
110
PsiBlast_CBE
39.71
32%
-17
- C1 -
-
3FVQ
2
FBPC_NEIG1
B:
[20-228]
----------------------
L
N
D
I
S
L
S
L
D
P
G
E
I
L
F
I
I
G
A
S
G
C
G
K
T
T
L
L
R
C
L
A
G
F
E
Q
P
D
S
G
E
----------
I
S
L
S
G
K
T
I
F
S
K
N
T
N
L
P
V
R
E
--
R
-
R
L
G
Y
L
V
Q
--
E
G
V
L
F
P
H
L
T
V
Y
R
N
I
A
Y
G
L
-
G
N
-------------------------
G
K
G
R
T
A
Q
E
R
QRIEAM
L
E
L
T
G
I
-
S
-
E
----
L
A
G
R
Y
P
H
E
L
S
G
G
Q
Q
Q
R
A
A
L
A
R
A
L
A
P
D
P
E
L
I
L
L
D
E
P
F
S
A
L
D
E
Q
L
R
R
Q
I
R
E
D
M
I
A
A
L
R
-
A
-
N
-
G
K
S
A
V
F
V
S
H
D
R
E
E
A
L
Q
Y
A
D
R
I
A
V
M
------
K
Q
G
R
----
I
L
Q
T
A
S
P
H
E
L
Y
R
-------------------------------------------------