@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : spr2034: (2018-01-25 )
MTKPIILTGDRPTGKLHIGHYVGSLKNRVLLQEEDKYDMFVFLADQQALTDHAKDPQTIVESIGNVALDYLAVGLDPNKSTIFIQSQIPELAELSMYYMNLVSLARLERNPTVKTEISQKGFGESIPTGFLVYPIAQAADITAFKANYVPVGTDQKPMIEQTREIVRSFNNAYNCDVLVEPEGIYPENERAGRLPGLDGNAKMSKSLNNGIYLADDADTLRKKVMSMYTDPDHIRVEDPGKIEGNMVFHYLDVFGRPEDAQEIADMKERYQRGGLGDVKTKRYLLEILERELGPIRERRIEFAKDMGEVYNMIQKGSERAREVAGQTLSEVKGAMGLHYFN
Atome Classification :
(20 SA)
.........10........20........30........40........50.-.......60........70........80........90........100.......110.......120.-......130.......140.......150.......160.......170.......180.......190.....-..200....---.---.---.---210-.........220.......230-.---...-..-.240.-......250.......260.......270.......280.......290.......300.......310.......320.......330.......340
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MTK
P
I
I
L
TGDRPT
G
K
L
H
I
G
H
Y
V
G
S
L
KN
R
V
L
LQEEDKY
D
M
F
V
F
LAD
Q
Q
A
L
T
DH-AK
D
P
Q
T
I
V
E
S
I
G
N
V
A
L
D
Y
L
AVGLDPNK
S
T
I
F
I
QSQI
P
E
L
A
E
L
S
M
Y
Y
M
N
L
V
S
L
A
R
LERNPT
V
K
T
E
I
SQKGFG-ESIPT
G
F
L
V
Y
PIAQAAD
I
T
A
FKAN
Y
V
PVGTDQ
K
P
M
I
E
Q
T
R
E
I
V
R
S
FNNAYN
C
D
V
L
VEPEGIYPENERAGRLPGL-DGN
A
K
M
S
K
S---L---N---N---
G
---
I
Y
LAD
D
A
D
T
L
R
K
K
V
M
S
MYTDP
D
-
H
---
I
RV-ED-PGKIE-G
N
M
V
F
H
Y
L
D
VFGRP
E
D
A
Q
E
I
A
D
M
K
E
R
Y
QRGGLG
D
V
K
T
K
R
Y
L
L
E
I
L
E
R
E
L
G
P
I
R
E
R
R
I
E
F
A
K
D
M
G
E
V
Y
N
M
I
Q
K
G
S
E
R
A
R
E
V
A
G
Q
T
L
S
E
V
K
G
AMGLHYFN
42
HHSearch
95.24
56%
-93
- C4 -
-
1YI8
-
SYW2_DEIRA
B:
[21-350]
-
A
R
P
R
V
L
T
G
D
R
P
T
G
A
L
H
L
G
H
L
A
G
S
L
Q
N
R
V
R
L
Q
D
-
E
-
A
E
L
F
V
L
L
A
D
V
Q
A
L
T
D
H
-
F
D
R
P
E
Q
V
R
E
N
V
L
A
V
A
L
D
Y
L
A
A
G
L
D
P
Q
K
T
T
C
V
V
Q
S
A
V
P
E
L
A
E
L
T
V
Y
F
L
N
L
V
T
V
S
H
L
R
Q
N
P
T
V
K
A
E
I
A
Q
K
G
Y
G
-
E
R
V
P
A
G
F
F
V
Y
P
V
S
Q
A
A
D
I
A
A
F
G
A
T
L
V
P
V
G
D
D
Q
L
P
M
L
E
Q
T
R
E
I
V
R
R
F
N
A
L
Y
A
-
P
V
L
A
E
P
Q
A
Q
L
S
R
V
P
---
R
L
P
G
L
-
D
G
Q
A
K
M
S
K
S
---
L
---
G
---
N
---
A
---
I
A
L
G
D
S
A
D
E
V
A
R
K
V
M
G
M
Y
T
D
P
G
-
H
---
L
R
A
-
S
D
-
P
G
R
V
E
-
G
N
P
V
F
T
F
L
D
A
F
D
P
D
P
--
A
R
V
Q
A
L
K
D
Q
Y
R
A
G
G
L
G
D
V
K
V
K
K
H
L
I
D
V
L
N
G
V
L
A
P
I
R
T
R
R
A
E
Y
E
R
D
P
D
A
V
L
R
F
V
T
E
G
T
A
R
G
R
E
V
A
A
Q
T
L
G
Q
V
R
R
A
M
R
L
F
G
--
43
HHSearch
94.69
56%
-94
- C4 -
-
2A4M
-
SYW2_DEIRA
A:
[22-350]
--
R
P
R
V
L
T
G
D
R
P
T
G
A
L
H
L
G
H
L
A
G
S
L
Q
N
R
V
R
L
Q
D
-
E
-
A
E
L
F
V
L
L
A
D
V
Q
A
L
T
D
H
-
F
D
R
P
E
Q
V
R
E
N
V
L
A
V
A
L
D
Y
L
A
A
G
L
D
P
Q
K
T
T
C
V
V
Q
S
A
V
P
E
L
A
E
L
T
V
Y
F
L
N
L
V
T
V
S
H
L
R
Q
N
P
T
V
K
A
E
I
A
Q
K
G
Y
G
-
E
R
V
P
A
G
F
F
V
Y
P
V
S
Q
A
A
D
I
A
A
F
G
A
T
L
V
P
V
G
D
D
Q
L
P
M
L
E
Q
T
R
E
I
V
R
R
F
N
A
L
Y
A
-
P
V
L
A
E
P
Q
A
Q
L
S
R
V
P
---
R
L
P
G
L
-
D
G
Q
A
K
M
S
K
S
---
L
---
G
---
N
---
A
---
I
A
L
G
D
S
A
D
E
V
A
R
K
V
M
G
M
Y
T
D
P
G
-
H
---
L
R
A
-
S
D
-
P
G
R
V
E
-
G
N
P
V
F
T
F
L
D
A
F
D
P
D
--
P
A
R
V
Q
A
L
K
D
Q
Y
R
A
G
G
L
G
D
V
K
V
K
K
H
L
I
D
V
L
N
G
V
L
A
P
I
R
T
R
R
A
E
Y
E
R
D
P
D
A
V
L
R
F
V
T
E
G
T
A
R
G
R
E
V
A
A
Q
T
L
G
Q
V
R
R
A
M
R
L
F
G
--
21
PsiBlast_CBE
93.77
55%
-93
- C4 -
-
2A4M
1
SYW2_DEIRA
C:
[21-348]
-
A
R
P
R
V
L
T
G
D
R
P
T
G
A
L
H
L
G
H
L
A
G
S
L
Q
N
R
V
R
L
Q
--
D
E
A
E
L
F
V
L
L
A
D
V
Q
A
L
T
D
H
-
F
D
R
P
E
Q
V
R
E
N
V
L
A
V
A
L
D
Y
L
A
A
G
L
D
P
Q
K
T
T
C
V
V
Q
S
A
V
P
E
L
A
E
L
T
V
Y
F
L
N
L
V
T
V
S
H
L
R
Q
N
P
T
V
K
A
E
I
A
Q
K
G
Y
G
-
E
R
V
P
A
G
F
F
V
Y
P
V
S
Q
A
A
D
I
A
A
F
G
A
T
L
V
P
V
G
D
D
Q
L
P
M
L
E
Q
T
R
E
I
V
R
R
F
N
A
L
Y
-
A
P
V
L
A
E
P
Q
A
---
Q
L
S
R
V
P
R
L
P
G
L
-
D
G
Q
A
K
M
S
K
S
---
L
---
G
---
N
---
A
---
I
A
L
G
D
S
A
D
E
V
A
R
K
V
M
G
M
Y
T
D
P
G
-
H
---
L
R
A
-
S
D
-
P
G
R
V
E
-
G
N
P
V
F
T
F
L
D
A
F
D
--
P
D
P
A
R
V
Q
A
L
K
D
Q
Y
R
A
G
G
L
G
D
V
K
V
K
K
H
L
I
D
V
L
N
G
V
L
A
P
I
R
T
R
R
A
E
Y
E
R
D
P
D
A
V
L
R
F
V
T
E
G
T
A
R
G
R
E
V
A
A
Q
T
L
G
Q
V
R
R
A
M
R
L
----
22
PsiBlast_CBE
93.05
56%
-98
- C4 -
-
1YI8
1
SYW2_DEIRA
C:
[25-348]
-----
V
L
T
G
D
R
P
T
G
A
L
H
L
G
H
L
A
G
S
L
Q
N
R
V
R
L
Q
--
D
E
A
E
L
F
V
L
L
A
D
V
Q
A
L
T
D
H
-
F
D
R
P
E
Q
V
R
E
N
V
L
A
V
A
L
D
Y
L
A
A
G
L
D
P
Q
K
T
T
C
V
V
Q
S
A
V
P
E
L
A
E
L
T
V
Y
F
L
N
L
V
T
V
S
H
L
R
Q
N
P
T
V
K
A
E
I
A
Q
K
G
Y
G
-
E
R
V
P
A
G
F
F
V
Y
P
V
S
Q
A
A
D
I
A
A
F
G
A
T
L
V
P
V
G
D
D
Q
L
P
M
L
E
Q
T
R
E
I
V
R
R
F
N
A
L
Y
-
A
P
V
L
A
E
P
Q
A
---
Q
L
S
R
V
P
R
L
P
G
L
-
D
G
Q
A
K
M
S
K
S
---
L
---
G
---
N
---
A
---
I
A
L
G
D
S
A
D
E
V
A
R
K
V
M
G
M
Y
T
D
P
G
-
H
---
L
R
A
-
S
D
-
P
G
R
V
E
-
G
N
P
V
F
T
F
L
D
A
F
D
--
P
D
P
A
R
V
Q
A
L
K
D
Q
Y
R
A
G
G
L
G
D
V
K
V
K
K
H
L
I
D
V
L
N
G
V
L
A
P
I
R
T
R
R
A
E
Y
E
R
D
P
D
A
V
L
R
F
V
T
E
G
T
A
R
G
R
E
V
A
A
Q
T
L
G
Q
V
R
R
A
M
R
L
----
2
PsiBlast_PDB
92.28
56%
-95
- C4 -
-
1YI8
-
SYW2_DEIRA
B:
[25-348]
-----
V
L
T
G
D
R
P
T
G
A
L
H
L
G
H
L
A
G
S
L
Q
N
R
V
R
L
Q
--
D
E
A
E
L
F
V
L
L
A
D
V
Q
A
L
T
D
H
-
F
D
R
P
E
Q
V
R
E
N
V
L
A
V
A
L
D
Y
L
A
A
G
L
D
P
Q
K
T
T
C
V
V
Q
S
A
V
P
E
L
A
E
L
T
V
Y
F
L
N
L
V
T
V
S
H
L
R
Q
N
P
T
V
K
A
E
I
A
Q
K
G
Y
G
-
E
R
V
P
A
G
F
F
V
Y
P
V
S
Q
A
A
D
I
A
A
F
G
A
T
L
V
P
V
G
D
D
Q
L
P
M
L
E
Q
T
R
E
I
V
R
R
F
N
A
L
Y
-
A
P
V
L
A
E
P
Q
A
---
Q
L
S
R
V
P
R
L
P
G
L
-
D
G
Q
A
K
M
S
K
S
---
L
---
G
---
N
---
A
---
I
A
L
G
D
S
A
D
E
V
A
R
K
V
M
G
M
Y
T
D
P
G
-
H
---
L
R
A
-
S
D
-
P
G
R
V
E
-
G
N
P
V
F
T
F
L
D
A
F
D
--
P
D
P
A
R
V
Q
A
L
K
D
Q
Y
R
A
G
G
L
G
D
V
K
V
K
K
H
L
I
D
V
L
N
G
V
L
A
P
I
R
T
R
R
A
E
Y
E
R
D
P
D
A
V
L
R
F
V
T
E
G
T
A
R
G
R
E
V
A
A
Q
T
L
G
Q
V
R
R
A
M
R
L
----
1
PsiBlast_PDB
92.17
55%
-92
- C4 -
-
2A4M
-
SYW2_DEIRA
A:
[21-348]
-
A
R
P
R
V
L
T
G
D
R
P
T
G
A
L
H
L
G
H
L
A
G
S
L
Q
N
R
V
R
L
Q
--
D
E
A
E
L
F
V
L
L
A
D
V
Q
A
L
T
D
H
-
F
D
R
P
E
Q
V
R
E
N
V
L
A
V
A
L
D
Y
L
A
A
G
L
D
P
Q
K
T
T
C
V
V
Q
S
A
V
P
E
L
A
E
L
T
V
Y
F
L
N
L
V
T
V
S
H
L
R
Q
N
P
T
V
K
A
E
I
A
Q
K
G
Y
G
-
E
R
V
P
A
G
F
F
V
Y
P
V
S
Q
A
A
D
I
A
A
F
G
A
T
L
V
P
V
G
D
D
Q
L
P
M
L
E
Q
T
R
E
I
V
R
R
F
N
A
L
Y
-
A
P
V
L
A
E
P
Q
A
---
Q
L
S
R
V
P
R
L
P
G
L
-
D
G
Q
A
K
M
S
K
S
---
L
---
G
---
N
---
A
---
I
A
L
G
D
S
A
D
E
V
A
R
K
V
M
G
M
Y
T
D
P
G
-
H
---
L
R
A
-
S
D
-
P
G
R
V
E
-
G
N
P
V
F
T
F
L
D
A
F
D
--
P
D
P
A
R
V
Q
A
L
K
D
Q
Y
R
A
G
G
L
G
D
V
K
V
K
K
H
L
I
D
V
L
N
G
V
L
A
P
I
R
T
R
R
A
E
Y
E
R
D
P
D
A
V
L
R
F
V
T
E
G
T
A
R
G
R
E
V
A
A
Q
T
L
G
Q
V
R
R
A
M
R
L
----
3
PsiBlast_PDB
91.47
56%
-97
- C4 -
-
1YIA
1
SYW2_DEIRA
B:
[25-348]
-----
V
L
T
G
D
R
P
T
G
A
L
H
L
G
H
L
A
G
S
L
Q
N
R
V
R
L
Q
--
D
E
A
E
L
F
V
L
L
A
D
V
Q
A
L
T
D
H
-
F
D
R
P
E
Q
V
R
E
N
V
L
A
V
A
L
D
Y
L
A
A
G
L
D
P
Q
K
T
T
C
V
V
Q
S
A
V
P
E
L
A
E
L
T
V
Y
F
L
N
L
V
T
V
S
H
L
R
Q
N
P
T
V
K
A
E
I
A
Q
K
G
Y
G
-
E
R
V
P
A
G
F
F
V
Y
P
V
S
Q
A
A
D
I
A
A
F
G
A
T
L
V
P
V
G
D
D
Q
L
P
M
L
E
Q
T
R
E
I
V
R
R
F
N
A
L
Y
-
A
P
V
L
A
E
P
Q
A
---
Q
L
S
R
V
P
R
L
P
G
L
-
D
G
Q
A
K
M
S
K
S
---
L
---
G
---
N
---
A
---
I
A
L
G
D
S
A
D
E
V
A
R
K
V
M
G
M
Y
T
D
P
G
-
H
---
L
R
A
-
S
D
-
P
G
R
V
E
-
G
N
P
V
F
T
F
L
D
A
F
D
--
P
D
P
A
R
V
Q
A
L
K
D
Q
Y
R
A
G
G
L
G
D
V
K
V
K
K
H
L
I
D
V
L
N
G
V
L
A
P
I
R
T
R
R
A
E
Y
E
R
D
P
D
A
V
L
R
F
V
T
E
G
T
A
R
G
R
E
V
A
A
Q
T
L
G
Q
V
R
R
A
M
R
L
----
4
PsiBlast_PDB
91.45
56%
-93
- C4 -
-
1YID
1
SYW2_DEIRA
B:
[25-348]
-----
V
L
T
G
D
R
P
T
G
A
L
H
L
G
H
L
A
G
S
L
Q
N
R
V
R
L
Q
--
D
E
A
E
L
F
V
L
L
A
D
V
Q
A
L
T
D
H
-
F
D
R
P
E
Q
V
R
E
N
V
L
A
V
A
L
D
Y
L
A
A
G
L
D
P
Q
K
T
T
C
V
V
Q
S
A
V
P
E
L
A
E
L
T
V
Y
F
L
N
L
V
T
V
S
H
L
R
Q
N
P
T
V
K
A
E
I
A
Q
K
G
Y
G
-
E
R
V
P
A
G
F
F
V
Y
P
V
S
Q
A
A
D
I
A
A
F
G
A
T
L
V
P
V
G
D
D
Q
L
P
M
L
E
Q
T
R
E
I
V
R
R
F
N
A
L
Y
-
A
P
V
L
A
E
P
Q
A
---
Q
L
S
R
V
P
R
L
P
G
L
-
D
G
Q
A
K
M
S
K
S
---
L
---
G
---
N
---
A
---
I
A
L
G
D
S
A
D
E
V
A
R
K
V
M
G
M
Y
T
D
P
G
-
H
---
L
R
A
-
S
D
-
P
G
R
V
E
-
G
N
P
V
F
T
F
L
D
A
F
D
--
P
D
P
A
R
V
Q
A
L
K
D
Q
Y
R
A
G
G
L
G
D
V
K
V
K
K
H
L
I
D
V
L
N
G
V
L
A
P
I
R
T
R
R
A
E
Y
E
R
D
P
D
A
V
L
R
F
V
T
E
G
T
A
R
G
R
E
V
A
A
Q
T
L
G
Q
V
R
R
A
M
R
L
----
45
HHSearch
88.40
44%
-110
- C4 -
-
2G36
2
SYW_THEMA
A:
[12-339]
--
H
M
R
I
L
S
G
M
R
P
T
G
K
L
H
I
G
H
L
V
G
A
L
E
N
W
V
K
L
Q
E
E
G
-
N
E
C
F
Y
F
V
A
D
W
H
A
L
T
T
H
-
Y
D
D
V
S
K
L
K
E
Y
T
R
D
L
V
R
G
F
L
A
C
G
I
D
P
E
K
S
V
I
F
V
Q
S
G
V
K
E
H
A
E
L
A
L
L
F
S
M
I
V
S
V
S
R
L
E
R
V
P
T
Y
K
E
I
--------
D
L
S
T
A
G
F
L
I
Y
P
V
L
Q
A
A
D
I
L
I
Y
K
A
E
G
V
P
V
G
E
D
Q
V
Y
H
I
E
L
T
R
E
I
A
R
R
F
N
Y
L
Y
D
-
E
V
F
P
E
P
E
A
I
L
S
R
V
P
---
K
L
P
G
T
-
D
G
-
R
K
M
S
K
S
---
Y
---
G
---
N
---
I
---
I
N
L
E
I
S
E
K
E
L
E
Q
T
I
L
R
M
M
T
D
P
A
-
R
---
V
R
R
-
S
D
-
P
G
N
P
E
-
N
C
P
V
W
K
Y
H
Q
A
F
D
I
S
E
--
E
E
S
K
W
V
W
E
G
C
T
T
A
S
I
G
C
V
D
C
K
K
L
L
L
K
N
M
K
R
K
L
A
P
I
W
E
N
F
R
K
I
D
E
D
P
H
Y
V
D
D
V
I
M
E
G
T
K
K
A
R
E
V
A
A
K
T
M
E
E
V
R
R
A
M
N
L
M
---
5
PsiBlast_PDB
85.60
43%
-110
- C4 -
-
2G36
2
SYW_THEMA
A:
[15-340]
-----
I
L
S
G
M
R
P
T
G
K
L
H
I
G
H
L
V
G
A
L
E
N
W
V
K
L
Q
E
E
G
N
-
E
C
F
Y
F
V
A
D
W
H
A
L
T
T
H
-
Y
D
D
V
S
K
L
K
E
Y
T
R
D
L
V
R
G
F
L
A
C
G
I
D
P
E
K
S
V
I
F
V
Q
S
G
V
K
E
H
A
E
L
A
L
L
F
S
M
I
V
S
V
S
R
L
E
R
V
P
T
Y
K
E
I
--------
D
L
S
T
A
G
F
L
I
Y
P
V
L
Q
A
A
D
I
L
I
Y
K
A
E
G
V
P
V
G
E
D
Q
V
Y
H
I
E
L
T
R
E
I
A
R
R
F
N
Y
L
Y
D
-
E
V
F
P
E
P
E
A
I
L
---
S
R
V
P
K
L
P
G
T
-
D
G
R
-
K
M
S
K
S
---
Y
---
G
---
N
---
I
---
I
N
L
E
I
S
E
K
E
L
E
Q
T
I
L
R
M
M
T
D
P
A
-
R
---
V
R
R
-
S
D
-
P
G
N
P
E
-
N
C
P
V
W
K
Y
H
Q
A
F
D
I
S
E
--
E
E
S
K
W
V
W
E
G
C
T
T
A
S
I
G
C
V
D
C
K
K
L
L
L
K
N
M
K
R
K
L
A
P
I
W
E
N
F
R
K
I
D
E
D
P
H
Y
V
D
D
V
I
M
E
G
T
K
K
A
R
E
V
A
A
K
T
M
E
E
V
R
R
A
M
N
L
M
F
--
52
HHSearch
81.11
32%
-119
- C4 -
-
3TZL
2
SYW_CAMJE
B:
[3-322]
--
A
M
R
V
L
T
G
L
Q
P
S
G
D
L
H
I
G
N
Y
F
G
A
I
K
Q
M
V
D
A
Q
E
-
K
-
S
Q
M
F
M
F
I
A
N
Y
H
A
M
T
S
S
-
Q
-
D
G
E
K
L
K
Q
N
S
L
K
A
A
A
A
F
L
S
L
G
I
D
P
Q
K
S
V
F
W
L
Q
S
D
V
K
E
V
M
E
L
Y
W
I
L
S
Q
F
T
P
M
G
L
L
E
R
A
H
S
Y
K
D
K
V
A
K
---
G
-
L
S
A
S
H
G
L
F
S
Y
P
V
L
M
A
A
D
I
L
L
F
D
T
R
I
V
P
V
G
K
D
Q
I
Q
H
V
E
I
A
R
D
I
A
L
K
V
N
N
E
W
G
E
-
I
F
T
L
P
E
A
R
V
N
--
E
E
V
A
V
V
V
G
T
-
D
G
-
A
K
M
S
K
S
---
Y
---
Q
---
N
---
T
---
I
D
I
F
S
S
E
K
T
L
K
K
Q
I
S
S
I
V
T
D
S
T
------
A
L
-
E
D
-
P
K
D
H
E
-
N
C
N
I
F
K
I
A
K
L
F
L
D
E
S
---
G
Q
K
E
L
Q
I
R
Y
E
K
G
G
E
G
Y
G
H
F
K
I
Y
L
N
E
L
V
N
A
Y
F
K
E
A
R
E
K
Y
N
E
L
L
E
K
P
S
H
L
K
E
I
L
D
F
G
A
T
K
A
R
K
I
A
Q
E
K
M
Q
K
I
Y
E
K
I
G
L
----
20
PsiBlast_PDB
80.83
31%
-120
- C4 -
-
3M5W
1
SYW_CAMJE
A:
[6-322]
-----
V
L
T
G
L
Q
P
S
G
D
L
H
I
G
N
Y
F
G
A
I
K
Q
M
V
D
A
Q
E
--
K
S
Q
M
F
M
F
I
A
N
Y
H
A
M
T
S
--
S
Q
D
G
E
K
L
K
Q
N
S
L
K
A
A
A
A
F
L
S
L
G
I
D
P
Q
K
S
V
F
W
L
Q
S
D
V
K
E
V
M
E
L
Y
W
I
L
S
Q
F
T
P
M
G
L
L
E
R
A
H
S
Y
K
D
-----------
A
S
H
G
L
F
S
Y
P
V
L
M
A
A
D
I
L
L
F
D
T
R
I
V
P
V
G
K
D
Q
I
Q
H
V
E
I
A
R
D
I
A
L
K
V
N
N
E
W
G
-
E
I
F
T
L
P
E
A
--
R
V
----
A
V
V
V
G
T
-
D
G
-
A
K
M
S
K
S
---
Y
---
Q
---
N
---
T
---
I
D
I
F
S
S
E
K
T
L
K
K
Q
I
S
S
I
V
T
D
S
------
T
A
L
-
E
D
-
P
K
D
H
E
-
N
C
N
I
F
K
I
A
K
L
F
-
L
D
E
S
G
Q
K
--
E
L
Q
I
R
Y
E
K
G
G
E
G
Y
G
H
F
K
I
Y
L
N
E
L
V
N
A
Y
F
K
E
A
R
E
K
Y
N
E
L
L
E
K
P
S
H
L
K
E
I
L
D
F
G
A
T
K
A
R
K
I
A
Q
E
K
M
Q
K
I
Y
E
K
I
G
L
----
51
HHSearch
79.48
32%
-114
- C4 -
-
3TZL
2
SYW_CAMJE
A:
[4-322]
---
M
R
V
L
T
G
L
Q
P
S
G
D
L
H
I
G
N
Y
F
G
A
I
K
Q
M
V
D
A
Q
E
-
K
-
S
Q
M
F
M
F
I
A
N
Y
H
A
M
T
S
S
-
Q
-
D
G
E
K
L
K
Q
N
S
L
K
A
A
A
A
F
L
S
L
G
I
D
P
Q
K
S
V
F
W
L
Q
S
D
V
K
E
V
M
E
L
Y
W
I
L
S
Q
F
T
P
M
G
L
L
E
R
A
H
S
Y
K
D
K
V
A
K
---
G
-
L
S
A
S
H
G
L
F
S
Y
P
V
L
M
A
A
D
I
L
L
F
D
T
R
I
V
P
V
G
K
D
Q
I
Q
H
V
E
I
A
R
D
I
A
L
K
V
N
N
E
W
G
E
-
I
F
T
L
P
E
A
R
V
N
--
E
E
V
A
V
V
V
G
T
-
D
G
-
A
K
M
S
K
S
---
Y
---
Q
---
N
---
T
---
I
D
I
F
S
S
E
K
T
L
K
K
Q
I
S
S
I
V
T
D
S
T
------
A
L
-
E
D
-
P
K
D
H
E
-
N
C
N
I
F
K
I
A
K
L
F
L
D
E
S
---
G
Q
K
E
L
Q
I
R
Y
E
K
G
G
E
G
Y
G
H
F
K
I
Y
L
N
E
L
V
N
A
Y
F
K
E
A
R
E
K
Y
N
E
L
L
E
K
P
S
H
L
K
E
I
L
D
F
G
A
T
K
A
R
K
I
A
Q
E
K
M
Q
K
I
Y
E
K
I
G
L
----
53
HHSearch
79.16
33%
-67
- C4 -
-
5V0I
5
SYW_ECOLI
B:
[5-336]
-
T
K
P
I
V
F
S
G
A
Q
P
S
G
E
L
T
I
G
N
Y
M
G
A
L
R
Q
W
V
N
M
Q
-
D
D
-
Y
H
C
I
Y
C
I
V
D
Q
H
A
I
T
V
R
-
Q
-
D
A
Q
K
L
R
K
A
T
L
D
T
L
A
L
Y
L
A
C
G
I
D
P
E
K
S
T
I
F
V
Q
S
H
V
P
E
H
A
Q
L
G
W
A
L
N
C
Y
T
Y
F
G
E
L
S
R
M
T
Q
F
K
---
A
R
Y
--
A
-
E
N
I
N
A
G
L
F
D
Y
P
V
L
M
A
A
D
I
L
L
Y
Q
T
N
L
V
P
V
G
E
D
Q
K
Q
H
L
E
L
S
R
D
I
A
Q
R
F
N
A
L
Y
G
-
D
I
F
K
V
P
E
P
F
-------
A
R
V
M
S
L
L
E
P
T
K
K
M
S
K
S
---
D
DNR
N
---
N
---
V
---
I
G
L
L
E
D
P
K
S
V
V
K
K
I
K
R
A
V
T
D
S
D
-
E
PPV
V
R
Y
-
D
V
-
Q
N
K
A
G
-
V
S
N
L
L
D
I
L
S
A
V
T
G
----
Q
S
I
P
E
L
E
K
Q
F
E
-
G
-
K
M
Y
G
H
L
K
G
E
V
A
D
A
V
S
G
M
L
T
E
L
Q
E
R
Y
H
R
F
R
N
D
E
A
F
L
Q
Q
V
M
K
D
G
A
E
K
A
S
A
H
A
S
R
T
L
K
A
V
Y
E
A
I
G
F
V
A
K
-
6
PsiBlast_PDB
75.78
40%
-18
- C4 -
-
2EL7
-
?
A:
[4-327]
-----
V
L
S
G
I
Q
P
S
G
E
I
H
I
G
N
Y
L
G
A
I
K
Q
W
V
A
I
G
E
K
L
G
R
D
A
F
F
C
I
V
D
Y
H
A
L
T
N
P
L
A
Y
D
P
S
T
L
A
Q
R
T
F
E
A
A
L
V
N
I
A
A
G
L
D
P
E
K
V
T
L
F
V
Q
S
H
V
P
E
H
T
E
L
S
W
V
F
T
T
L
T
P
L
G
D
L
T
R
M
T
Q
F
K
D
K
A
S
K
Q
----
E
T
V
W
S
G
L
L
M
Y
P
V
L
Q
A
A
D
I
L
I
Y
K
A
D
T
V
P
V
G
E
D
Q
V
Q
H
I
E
L
T
R
E
I
A
R
R
F
N
H
L
F
G
-
E
T
F
P
E
P
Q
A
L
L
--
N
P
E
A
P
R
V
P
G
I
-
D
G
K
A
K
M
S
K
S
---
L
---
G
---
N
---
T
---
I
G
L
L
E
P
E
E
S
I
W
Q
K
I
Q
H
L
P
D
D
P
--------------------
T
I
L
F
T
Y
L
S
Y
F
A
-
P
K
D
L
V
E
A
--
L
K
E
E
Y
R
K
A
G
V
G
T
Y
V
V
K
R
I
L
F
D
H
L
M
E
A
L
R
P
I
R
E
R
A
E
A
L
K
K
D
P
D
Y
V
M
D
A
L
L
E
G
A
K
R
A
R
A
V
A
Q
A
T
M
E
E
V
R
E
K
V
G
L
----
62
Fugue
75.01
33%
-55
- C4 -
-
1D2R
-
SYW_GEOSE
A:
[1-326]
--
M
K
T
I
F
S
G
I
Q
P
S
G
V
I
T
I
G
N
Y
I
G
A
L
R
Q
F
V
E
L
Q
H
E
--
Y
N
C
Y
F
C
I
V
D
Q
H
A
I
T
V
W
--
Q
D
P
H
E
L
R
Q
N
I
R
R
L
A
A
L
Y
L
A
V
G
I
D
P
T
Q
A
T
L
F
I
Q
S
E
V
P
A
H
A
Q
A
A
W
M
L
Q
C
I
V
Y
I
G
E
L
E
R
M
T
Q
F
K
E
K
S
A
G
A
----
A
A
A
A
A
G
L
L
T
Y
P
P
L
M
A
A
D
I
L
L
Y
N
T
D
I
V
P
V
G
E
D
Q
K
Q
H
I
E
L
T
R
D
L
A
E
R
F
N
K
R
Y
G
-
E
L
F
T
I
P
E
A
R
I
P
K
V
G
-
A
R
I
M
S
L
V
-
D
P
T
K
K
M
S
K
S
DPN
P
---
K
---
A
---
Y
---
I
T
L
L
D
D
A
K
T
I
E
K
K
I
K
S
A
V
T
D
S
E
-
G
T--
I
R
Y
-
D
K
-
E
A
K
P
G
-
I
S
N
L
L
N
I
Y
S
T
L
S
G
----
Q
S
I
E
E
L
E
R
Q
Y
E
--
G
K
G
Y
G
V
F
K
A
D
L
A
Q
V
V
I
E
T
L
R
P
I
Q
E
R
Y
H
H
W
M
E
S
-
E
E
L
D
R
V
L
D
E
G
A
E
K
A
N
R
V
A
S
E
M
V
R
K
M
E
Q
A
M
G
L
G
R
--
36
PsiBlast_CBE
74.87
32%
-35
- C4 -
-
5V0I
5
SYW_ECOLI
B:
[5-333]
-
T
K
P
I
V
F
S
G
A
Q
P
S
G
E
L
T
I
G
N
Y
M
G
A
L
R
Q
W
V
N
M
Q
--
D
D
Y
H
C
I
Y
C
I
V
D
Q
H
A
I
T
V
R
--
Q
D
A
Q
K
L
R
K
A
T
L
D
T
L
A
L
Y
L
A
C
G
I
D
P
E
K
S
T
I
F
V
Q
S
H
V
P
E
H
A
Q
L
G
W
A
L
N
C
Y
T
Y
F
G
E
L
S
R
M
T
Q
F
K
---
A
R
--
Y
A
-
E
N
I
N
A
G
L
F
D
Y
P
V
L
M
A
A
D
I
L
L
Y
Q
T
N
L
V
P
V
G
E
D
Q
K
Q
H
L
E
L
S
R
D
I
A
Q
R
F
N
A
L
Y
G
-
D
I
F
K
V
P
E
P
F
------
A
R
V
M
S
L
L
-
E
P
T
K
K
M
S
K
S
DDN
R
---
N
---
N
---
V
---
I
G
L
L
E
D
P
K
S
V
V
K
K
I
K
R
A
V
T
D
S
D
-
E
---
P
P
V
-
V
R
-
Y
D
V
Q
N
-
K
A
G
V
S
N
L
L
D
I
L
S
-
A
V
T
G
Q
S
I
P
E
L
E
K
Q
F
E
G
K
M
Y
G
H
L
K
G
E
--
V
A
D
A
V
S
G
M
L
T
E
L
Q
E
R
Y
H
R
F
R
N
D
E
A
F
L
Q
Q
V
M
K
D
G
A
E
K
A
S
A
H
A
S
R
T
L
K
A
V
Y
E
A
I
G
F
----
31
PsiBlast_CBE
73.59
34%
-25
- C4 -
-
1MAW
1
SYW_GEOSE
F:
[4-324]
-----
I
F
S
G
I
Q
P
S
G
V
I
T
I
G
N
Y
I
G
A
L
R
Q
F
V
E
L
Q
H
E
--
Y
N
C
Y
F
C
I
V
D
Q
H
A
I
T
V
W
--
Q
D
P
H
E
L
R
Q
N
I
R
R
L
A
A
L
Y
L
A
V
G
I
D
P
T
Q
A
T
L
F
I
Q
S
E
V
P
A
H
A
Q
A
A
W
M
L
Q
C
I
V
Y
I
G
E
L
E
R
----
M
T
Q
F
K
E
K
S
A
G
K
E
A
V
S
A
G
L
L
T
Y
P
P
L
M
A
A
D
I
L
L
Y
N
T
D
I
V
P
V
G
E
D
Q
K
Q
H
I
E
L
T
R
D
L
A
E
R
F
N
K
R
Y
G
-
E
L
F
T
I
P
E
A
R
I
P
K
V
--
G
A
R
I
M
S
L
V
D
P
T
K
K
M
S
K
S
---
D
---
P
---
N
---
P
KAY
I
T
L
L
D
D
A
K
T
I
E
K
K
I
K
S
A
V
T
D
S
E
G
T
---
I
R
Y
-
D
K
-
E
A
K
P
G
I
S
N
L
L
N
I
Y
S
T
L
S
G
-----
Q
S
I
E
E
L
E
R
Q
Y
E
G
K
G
Y
G
V
F
K
A
D
--
L
A
Q
V
V
I
E
T
L
R
P
I
Q
E
R
Y
H
H
W
M
E
S
-
E
E
L
D
R
V
L
D
E
G
A
E
K
A
N
R
V
A
S
E
M
V
R
K
M
E
Q
A
M
G
L
----
46
HHSearch
73.33
35%
-25
- C4 -
-
3PRH
-
SYW_BACSU
A:
[2-327]
--
K
Q
T
I
F
S
G
I
Q
P
S
G
S
V
T
L
G
N
Y
I
G
A
M
K
Q
F
V
E
L
Q
-
H
D
-
Y
N
S
Y
F
C
I
V
D
Q
H
A
I
T
V
P
--
Q
D
R
L
E
L
R
K
N
I
R
N
L
A
A
L
Y
L
A
V
G
L
D
P
E
K
A
T
L
F
I
Q
S
E
V
P
A
H
A
Q
A
G
W
M
M
Q
C
V
A
Y
I
G
E
L
E
R
M
T
--------------
A
V
V
S
G
L
L
T
Y
P
P
L
M
A
A
D
I
L
L
Y
G
T
D
L
V
P
P
G
E
D
Q
K
Q
H
L
E
L
T
R
N
L
A
E
R
F
N
K
K
Y
N
-
D
I
F
T
I
P
E
V
K
I
P
K
--
V
G
A
R
I
M
S
L
N
D
P
L
K
K
M
S
K
S
---
D
---
P
NQK
A
---
Y
---
I
T
L
L
D
E
P
K
Q
L
E
K
K
I
K
S
A
V
T
D
S
E
-
G
---
I
V
K
-
F
D
K
E
N
K
P
G
-
V
S
N
L
L
T
I
Y
S
I
L
G
N
----
T
T
I
E
E
L
E
A
K
Y
E
--
G
K
G
Y
G
E
F
K
G
D
L
A
E
V
V
V
N
A
L
K
P
I
Q
D
R
Y
Y
E
L
I
E
S
-
E
E
L
D
R
I
L
D
E
G
A
E
R
A
N
R
T
A
N
K
M
L
K
K
M
E
N
A
M
G
L
G
R
--
56
HHSearch
73.16
34%
-35
- C4 -
-
1I6L
7
SYW_GEOSE
A:
[1-326]
--
M
K
T
I
F
S
G
I
Q
P
S
G
V
I
T
I
G
N
Y
I
G
A
L
R
Q
F
V
E
L
Q
H
-
E
-
Y
N
C
Y
F
C
I
V
D
Q
H
A
I
T
V
W
--
Q
D
P
H
E
L
R
Q
N
I
R
R
L
A
A
L
Y
L
A
V
G
I
D
P
T
Q
A
T
L
F
I
Q
S
E
V
P
A
H
A
Q
A
A
W
M
L
Q
C
I
V
Y
I
G
E
L
E
R
M
T
Q
F
K
E
K
S
A
---
G
K
-
E
A
V
S
A
G
L
L
T
Y
P
P
L
M
A
A
D
I
L
L
Y
N
T
D
I
V
P
V
G
E
D
Q
K
Q
H
I
E
L
T
R
D
L
A
E
R
F
N
K
R
Y
G
E
-
L
F
T
I
P
E
A
R
I
P
--
K
V
G
A
R
I
M
S
L
V
D
P
T
K
K
M
S
K
S
---
D
---
P
---
N
PKA
Y
---
I
T
L
L
D
D
A
K
T
I
E
K
K
I
K
S
A
V
T
D
S
E
-
G
---
T
I
R
Y
D
K
-
E
A
K
P
G
-
I
S
N
L
L
N
I
Y
S
T
L
S
G
----
Q
S
I
E
E
L
E
R
Q
Y
E
G
K
--
G
Y
G
V
F
K
A
D
L
A
Q
V
V
I
E
T
L
R
P
I
Q
E
R
Y
H
H
W
M
E
S
-
E
E
L
D
R
V
L
D
E
G
A
E
K
A
N
R
V
A
S
E
M
V
R
K
M
E
Q
A
M
G
L
G
R
--